CN100431592C

CN100431592C - Chinese medicinal formulation for treating hyperplasia of prostate

Info

Publication number: CN100431592C
Application number: CNB2006101145499A
Authority: CN
Inventors: 王信锁
Original assignee: BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
Current assignee: BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
Priority date: 2006-11-15
Filing date: 2006-11-15
Publication date: 2008-11-12
Anticipated expiration: 2026-11-15
Also published as: CN1961955A

Abstract

The invention relates to a traditional Chinese medicinal composition for treating prostate gland hyperplasia, which is prepared from raw materials including amber, giant knotweed rhizome, zedoary, peach kernels, climbing fern spore, rhubarb horsetails, pyrrosia leaf, wood louse, deglued antler powder, pangolin scales, lychee seed and pseudo-ginseng.

Description

A kind of Chinese medicine preparation for the treatment of prostatic hyperplasia

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of prostatic hyperplasia, is that a kind of prostatic hyperplasia for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Hyperplasia of prostate claims benign prostatic hyperplasia again, also claims prostate hyperplasia, is a kind of commonly encountered diseases that influences elderly men health that increases because of prostate is obvious.Be to cause old people's urine retention, the reason that urinary system infection and uremia are common.Hyperplasia of prostate is a clinical characters with carrying out property frequent micturition, dysuria, and early symptom is obscure, and along with lower urinary tract obstruction increases the weight of, symptom is obvious gradually.It is reported that domestic sickness rate accounts for 35% of male more than 40 years old, in fact may be higher.The sickness rate of external hyperplasia of prostate is apparently higher than domestic, the sick rational prostatic hyperplasia of the Crinis Carbonisatus of 50～60 years old elderly men nearly 50%, and at the elderly men more than 80 years old, its sickness rate can be up to 80%～90%.Hyperplasia of prostate belongs to the category of Chinese medicine " difficulty in urination ", " smart infirmity ".It is unobstructed that the traditional Chinese medical science thinks that the normal person urinates, and depend on the normal of qiactivity of triple energizer, and qiactivity of triple energizer mainly relies on lung spleen kidney three dirty keeping.So it is primary disease is except that having the substantial connection with kidney, also usually relevant with lung, spleen, three warmers.The clinical type Coryza Treated by Syndrome Differentiation such as damp invasion of lower energizer, deficiency of QI in middle-JIAO, kidney yang deficiency, damage of kidney-YIN, the resistance of the urinary tract stasis of blood, lung-heat heap soil or fertilizer over and around the roots Sheng, stagnation of QI due to depression of the liver that often are divided into.At present, the western medical treatment hyperplasia of prostate mainly adopts operative treatment.Side effect is big, and recurrence brings huge misery to the patient easily.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of prostatic hyperplasia, have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 parts of Spora Lygodii of 0.1～2 part of stir-baked RHIIZOMA CURCUMAE with vinegar of succinum

0.1～2 part of 1～4 part of Radix Et Rhizoma Rhei of 1.5～6 parts of Semen Persicae (parched)s of Rhizoma Polygoni Cuspidati

0.1～2 part of 0.1～2 part of Cornu Cervi Degelatinatum of 1.5～6 parts of Eupolyphaga Seu Steleophagas of Folium Pyrrosiae

0.1～2 part of 0.1～2 part of vinegar Squama Manis of 0.1～2 part of Semen Litchi of Radix Notoginseng

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 parts of Spora Lygodii of 0.5～1.5 part of stir-baked RHIIZOMA CURCUMAE with vinegar of succinum

0.5～1.5 part of 1.5～2.5 parts of Radix Et Rhizoma Rhei of 2.5～3.5 parts of Semen Persicae (parched)s of Rhizoma Polygoni Cuspidati

0.5～1.5 part of 0.5～1.5 part of Cornu Cervi Degelatinatum of 2.5～3.5 parts of Eupolyphaga Seu Steleophagas of Folium Pyrrosiae

0.5～1.5 part of 0.5～1.5 part of vinegar Squama Manis of 0.5～1.5 part of Semen Litchi of Radix Notoginseng

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 parts of Spora Lygodii of 1 part of stir-baked RHIIZOMA CURCUMAE with vinegar of succinum

1 part of 2 parts of Radix Et Rhizoma Rhei of 3 parts of Semen Persicae (parched)s of Rhizoma Polygoni Cuspidati

1 part of 1 part of Cornu Cervi Degelatinatum of 3 parts of Eupolyphaga Seu Steleophagas of Folium Pyrrosiae

1 part of 1 part of vinegar Squama Manis of 1 part of Semen Litchi of Radix Notoginseng

Drug action mechanism among the present invention is as follows:

The succinum nature and flavor are sweet, flat.Go into the heart, liver, small intestine meridian.Has tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, the effect of relieving stranguria by diuresis.Cure mainly and stop stasis of blood stomachache, skin sore, traumatic injury etc. in bladder cancer, nasopharyngeal carcinoma, rectal cancer, infantile convulsion epilepsy, palpitation with fear insomnia, stranguria with blood hematuria, urinary obstruction, women's amenorrhea, puerperal.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1152nd page).

The Rhizoma Polygoni Cuspidati mildly bitter flavor, be slightly cold.Return liver, gallbladder, lung meridian.Has expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm.Can treat arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus, cough with copious phlegm etc.(the 168th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Stir-baked RHIIZOMA CURCUMAE with vinegar nature and flavor hardship, suffering, temperature.Return liver, spleen channel.Have the circulation of qi promoting removing blood stasis with potent drugs, the removing food stagnancy pain relieving is changed poly-eliminating mass, the effect of antiearly pregnancy.Can treat that trusted subordinate's distending pain, lump in the abdomen, dyspepsia do not disappear, hepatosplenomegaly, abdominal pain due to blood stasis, amenorrhea due to stagnation of blood, cervical erosion, traumatic injury have a pain etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 995th page).

Semen Persicae (parched) nature and flavor hardship, sweet, flat.GUIXIN, liver, large intestine channel.Has blood stasis removing and clots absorbing, the effect of loosening bowel to relieve constipation.Can control amenorrhea, dysmenorrhea, mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 708th page).

The Spora Lygodii nature and flavor are sweet, salty, and are cold.Return bladder, small intestine meridian.Have eliminating damp-heat, treating stranguria analgesic effect.Can treat pyretic stranguria, sand Stranguria, stranguria caused by urinary stone, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain etc.(the 242nd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Radix Et Rhizoma Rhei nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.Can treat the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle is treated skin ulcer, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire, upper gastrointestinal hemorrhage etc.(the 19th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Folium Pyrrosiae nature and flavor are sweet, bitter, be slightly cold.Return lung, urinary bladder channel.Has inducing diuresis for treating stranguria syndrome, the effect of clearing away heat to stop bleeding.Be used for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drench the puckery pain of drop, spit blood epistaxis, hematuria, metrorrhagia, dyspnea and cough due to lung-heat etc.(the 68th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Eupolyphaga Seu Steleophaga nature and flavor are salty, and are cold; Slightly poisonous.Return Liver Channel.Has removing blood stasis with potent drugs blood, the effect of reuniting the fractured tendons and bones.Can treat the muscles and bones folding and hinder blood stasis amenorrhea ， mass in the abdomen mass in the abdomen etc.(the 16th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Cornu Cervi Degelatinatum nature and flavor are salty, temperature.Return liver, kidney channel.Has tonify deficiency, supporing yang effect.Can treat insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses etc.(" Chinese medicine voluminous dictionary " the 2241st page).

Vinegar Squama Manis nature and flavor are salty, cool, be slightly cold.Return liver, stomach warp.Has detumescence and apocenosis, dredging collateral for promoting lactation, promoting blood circulation and stopping pain, the effect of removing food stagnancy.Can control carbuncle sore tumefacting virus becomes to burst galactostasis, anemofrigid-damp arthralgia, amenorrhea, infantile malnutrition stomachache, dyspepsia, traumatic hemorrhage, hematuria, the tuberculosis of cervical lymph nodes etc. from the beginning of, pus.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 956th page).

The Semen Litchi sweet-puckery flavor, temperature.Return liver, kidney channel.Have warming middle-JIAO, regulate the flow of vital energy, the analgesic effect.Can treat gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood etc.(" Chinese medicine voluminous dictionary " the 1616th page.)

Sweet, the little hardship of Radix Notoginseng nature and flavor, temperature.Return liver, stomach warp.Has the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.Can treat spitting of blood, spit blood, have blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling etc.(the 10th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with succinum, Rhizoma Polygoni Cuspidati and Spora Lygodii; With stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Persicae (parched), Folium Pyrrosiae, Eupolyphaga Seu Steleophaga, Cornu Cervi Degelatinatum and vinegar Squama Manis is ministerial drug; With Radix Et Rhizoma Rhei, Semen Litchi and Radix Notoginseng is adjuvant.All medicines have eliminating damp-heat, inducing diuresis for treating stranguria syndrome, dissipating blood stasis hemostatic effect mutually and altogether, treatment and prevention of prostatic hyperplasia, and determined curative effect has no side effect, and taking convenience is cheap.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention of prostatic hyperplasia of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.

3, the present invention not only can effectively treat prostatic hyperplasia, and the prevention of prostatic hyperplasia is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.

Prostatic hyperplasia (difficulty in urination) curative effect determinate standard: (the 222nd page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).

1, cure: it is unobstructed to urinate, and symptom and sign disappear.

2, take a turn for the better: symptom and sign are improved.

3, do not heal: the symptom no change.

Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment prostatic hyperplasia.

As follows through clinical test results; Treatment prostatic hyperplasia patient 51 examples, the age is 50～72 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 28 examples and account for 54.9%, 20 examples that take a turn for the better account for 39.2%, and invalid 3 examples account for 5.8%, and total effective rate reaches more than 94%.After three course of therapy, patient's prostate obviously dwindles, and urinates unobstructed or reaches criterion of cure.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment 1 capsule takes by weighing raw material by following weight:

Preparation method is to get succinum earlier, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis drying and crushing to 120～200 order fine powders, get Rhizoma Polygoni Cuspidati again, stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Persicae (parched), Spora Lygodii, Radix Et Rhizoma Rhei, Folium Pyrrosiae, Eupolyphaga Seu Steleophaga and Semen Litchi decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and succinum, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, two months is a course of treatment.

Embodiment 2 tablets take by weighing raw material by following weight:

Preparation method is to get succinum earlier, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis drying and crushing to 120～200 order fine powders, get Rhizoma Polygoni Cuspidati again, stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Persicae (parched), Spora Lygodii, Radix Et Rhizoma Rhei, Folium Pyrrosiae, Eupolyphaga Seu Steleophaga and Semen Litchi decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and succinum, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis fine powder mixing, drying, be ground into fine powder, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, two months is a course of treatment.

Embodiment 3 granules take by weighing raw material by following weight:

Preparation method is to get succinum earlier, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis drying and crushing to 120～200 order fine powders, get Rhizoma Polygoni Cuspidati again, stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Persicae (parched), Spora Lygodii, Radix Et Rhizoma Rhei, Folium Pyrrosiae, Eupolyphaga Seu Steleophaga and Semen Litchi decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and succinum, Cornu Cervi Degelatinatum, Radix Notoginseng and vinegar Squama Manis fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, two months is a course of treatment.

Claims

1, a kind of Chinese medicine preparation for the treatment of prostatic hyperplasia is characterized in that it is made by following raw materials by weight proportions:

0.1～2 part of 0.1～2 part of vinegar Squama Manis of 0.1～2 part of Semen Litchi of Radix Notoginseng.

2, a kind of Chinese medicine preparation for the treatment of prostatic hyperplasia according to claim 1, wherein the weight proportion of each crude drug is:

0.5～1.5 part of 0.5～1.5 part of vinegar Squama Manis of 0.5～1.5 part of Semen Litchi of Radix Notoginseng.

3, a kind of Chinese medicine preparation for the treatment of prostatic hyperplasia according to claim 1, wherein the weight proportion of each crude drug is:

1 part of 1 part of vinegar Squama Manis of 1 part of Semen Litchi of Radix Notoginseng.