CN105250619A - Traditional Chinese medicine for treating intrinsic endometriosis and preparation method thereof - Google Patents

Abstract

The invention provides traditional Chinese medicine for treating intrinsic endometriosis and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials of tall monkshood roots, red yeast rice, daphne odera, lacca, peach blossoms, dysosma versipellis, evergreen mucuna roots and leaves, common achyranthes herbs, kirilow rhodiola rhizomes and roots, medical stones, sambucus chinensis, chili stems, oxalis acetosella, linearsegmented corydalis roots, hylotelephium verticillatum, daphniphyllum roots, hairyshoot elm bark, dutchmanspipe roots, semen aesculi, fleshfingered citron flowers, pummelo seeds, allium macrostemon, rhizoma nardostachyos and folia perillae acutae. The traditional Chinese medicine for treating the intrinsic endometriosis has the advantages of being convenient to use, free of toxic and side effects, high in effective rate and good in treating effect.

Description

A kind of Chinese medicine for the treatment of endometriosis interna and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine for the treatment of endometriosis interna and preparation method thereof.

Background technology

Modern medicine thinks that endometriosis interna disease refers to the endometrium with growth function, by uterus basilar part to flesh bottom growth, and is confined to uterus, therefore has another name called adenomyosis.The normal disperse of endometrium is in whole uterine muscular, fibrous tissue and myofibrillar reactive hyperplasia is caused because inner membrance invades, uterus concordance is swollen, the muscular tissue of tangent plane visible hyperplasia is also whirlpool spline structure like muscular tumor, there is softened zone in the middle of focus, occasionally can see the areola containing a small amount of outmoded hematocele be dispersed in.Ectopic Endometrium changes with menstrual cycle, but the secretory phase changes not obvious, affects less.Minority endometrial stromatosis is a kind of specific type of endometriosis interna disease, more rare, namely the inner membrance of dystopy only has inner membrance stroma, or endometrium invades the scope of stroma development after muscle layer and degree considerably beyond body of gland cost.

Endometrial tissue monthly can normally peel off, after excreting with menses, then the growth that goes round and begins again.And endometriosis refers to the endometrial tissue with growth function, appear at other positions of health beyond cavity of uterus wall as ovary, abdominal cavity, ureter, rectum recessed position or bladder, and cause gynaecopathia.The sense of discomfort of patient comprises: 1, dysmenorrhoea: premenstrually occur having an intense pain, distending pain, and pain may be extended down to anus, thigh, can cold extremities, vomiting etc. time serious; Come through after, pain slightly slows down, disappearance.Because part endometrial tissue possibility implantation is in rectum recessed position, pain can be caused during sexual intercourse, but 25% this disease patient can not have the symptom of dysmenorrhea yet.2, menoxenia: about 15 to 30% patients there will be through measuring more and more, situation about more and more growing menstrual period.3, rectal distention stimulation disease: because of endometrial tissue likely implantation in rectum recessed position, during menstrual period, can awareness of defecation be felt, occur distending pain at anus, perineum part, cause waist abdomen pain, symptom is disappearing through after date.4, infertile: because endometrial tissue grows in abnormal position, may tubal occlusion to be caused, again or ovary can not normally ovulate, lower and to become pregnant probability.

Traditional Chinese medical science scholar thinks that endometriosis interna disease belongs to " dysmenorrhea ", " micro-flaw ", " gathering ", " infertile ".Be discussed as in " General Treatise on the Cause and Symptoms of Diseases " " married woman's menstrual abdominalgia person, by impairment caused by overstrain QI and blood so that body void, air-cooled pathogen visitor is in collaterals of the uterus, and the arteries and veins of appointing is rushed in damage ".

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of therapeutic effect good and Chinese medicine of the treatment endometriosis interna that toxic and side effects is little and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of endometriosis interna, described Chinese medicine comprises following raw medicinal material: Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis, Radix achyranthis asperae (Herba Achyranthis Asperae), Rhizoma Rhodiolae kirilowii, Maifanitum, Herba Sambuci Chiensis, Caulis Capsici, SANYE Hydrocotyle vulgaris L., Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini, Cortex Ulmi virgatae, Radix Aristolochiae, Semen Aesculi, Flos Citri Sarcodactylis, Semen Citri grandis, Bulbus Allii Macrostemonis, Radix Et Rhizoma Nardostachyos and Folium Perillae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Radix aconiti sinomontani 10 ~ 25 parts, 15 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 10 ~ 20 parts, Lacca 10 ~ 30 parts, 10 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 10 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 15 ~ 30 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 ~ 25 parts, Rhizoma Rhodiolae kirilowii 10 ~ 30 parts, Maifanitum 10 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 20 parts, Caulis Capsici 15 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 15 ~ 30 parts, Radix corydalis linearioidis 10 ~ 30 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 25 parts, Radix Daphniphylli calycini 10 ~ 25 parts, Cortex Ulmi virgatae 10 ~ 20 parts, Radix Aristolochiae 10 ~ 30 parts, Semen Aesculi 10 ~ 30 parts, Flos Citri Sarcodactylis 10 ~ 20 parts, Semen Citri grandis 15 ~ 25 parts, Bulbus Allii Macrostemonis 10 ~ 25 parts, Radix Et Rhizoma Nardostachyos 10 ~ 20 parts and Folium Perillae 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Radix aconiti sinomontani 10 ~ 15 parts, 20 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 15 ~ 20 parts, Lacca 15 ~ 25 parts, 15 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 15 ~ 20 parts, Radix Seu Caulis Mucunae Sempervirentis 20 ~ 25 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Rhizoma Rhodiolae kirilowii 20 ~ 30 parts, Maifanitum 20 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 15 parts, Caulis Capsici 20 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 20 ~ 30 parts, Radix corydalis linearioidis 15 ~ 25 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 15 parts, Radix Daphniphylli calycini 15 ~ 20 parts, Cortex Ulmi virgatae 15 ~ 20 parts, Radix Aristolochiae 20 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Flos Citri Sarcodactylis 15 ~ 20 parts, Semen Citri grandis 20 ~ 25 parts, Bulbus Allii Macrostemonis 15 ~ 25 parts, Radix Et Rhizoma Nardostachyos 15 ~ 20 parts and Folium Perillae 20 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Radix aconiti sinomontani 13 parts, 23 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 18 parts, Lacca 20 parts, 21 parts, Flos persicae, Radix et Rhizoma Dysosmatis 18 parts, Radix Seu Caulis Mucunae Sempervirentis 22 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Rhizoma Rhodiolae kirilowii 25 parts, Maifanitum 26 parts, Herba Sambuci Chiensis 15 parts, Caulis Capsici 27 parts, SANYE Hydrocotyle vulgaris L. 25 parts, Radix corydalis linearioidis 23 parts, Hylotelephium verticillatum (Linn.) H. Ohba 13 parts, Radix Daphniphylli calycini 18 parts, Cortex Ulmi virgatae 16 parts, Radix Aristolochiae 25 parts, Semen Aesculi 20 parts, Flos Citri Sarcodactylis 15 parts, Semen Citri grandis 22 parts, Bulbus Allii Macrostemonis 20 parts, Radix Et Rhizoma Nardostachyos 18 parts and Folium Perillae 20 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis and Radix achyranthis asperae (Herba Achyranthis Asperae) are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Sambuci Chiensis, Caulis Capsici, Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini and Radix Aristolochiae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Beneficial effect of the present invention: the Chinese medicine that endometriosis interna of the present invention uses is easy to use, and have no side effect, effective percentage is high, and therapeutic effect is good.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of endometriosis interna, Chinese medicine comprises following raw medicinal material: Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis, Radix achyranthis asperae (Herba Achyranthis Asperae), Rhizoma Rhodiolae kirilowii, Maifanitum, Herba Sambuci Chiensis, Caulis Capsici, SANYE Hydrocotyle vulgaris L., Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini, Cortex Ulmi virgatae, Radix Aristolochiae, Semen Aesculi, Flos Citri Sarcodactylis, Semen Citri grandis, Bulbus Allii Macrostemonis, Radix Et Rhizoma Nardostachyos and Folium Perillae.

The pharmacology of various raw medicinal material is as follows:

Radix aconiti sinomontani: [source] medical material Ji Yuan: be the root of ranunculaceae plant Aconitum sinomontanum Nakai.[nature and flavor] are bitter; Pungent; Temperature; [return through] heart; Liver; Lung; Spleen channel.[function cures mainly] expelling wind and removing dampness; Regulating QI to relieve pain; Promoting blood circulation to remove blood stasis.Main lumbago, skelalgia of rheumatism; Arthralgia; Traumatic injury; Stomachache; Distension and fullness of the chest and abdomen; Acute and chronic bacillary dysentery; Acute chronic enteritis; Scrofula; Furuncle.[each discussion] 1. " Guizhou folk medicine ": control heart pain, peratodynia.2. " Guizhou medical herbs ": mind calming, regulate the flow of vital energy, pain relieving, blood circulation promoting and blood stasis dispelling.Control rash disease stomachache, peratodynia, cardiopalmus, traumatic injury.3. " Shaanxi Chinese herbal medicine ": promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, wind-damp dispelling.Control traumatic injury, fracture, lumbago, skelalgia of rheumatism, impairment caused by overstrain, furuncle, scrofula.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Monas cuspurpureus Went: [another name] red song, red song, red rice, good fortune song, red rice, red groove.[source] medical material Ji Yuan: the mycelium for Aspergillaceae fungus monascus colonizes in the Monas cuspurpureus Went on Semen oryzae sativae.[nature and flavor] are sweet; Temperature; Nontoxic; [return through] liver; Spleen; Stomach; Large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Strengthening the spleen to promote digestion.Main eating accumulation; Distension and fullness in the abdomen; Red white dysentery; Prolonged lochia; Traumatic injury.[each discussion] " detailed outline ": control woman's vim and vigour pain and puerperal stagnant blood not to the utmost, beat beverage good.Essentials of Matea Medica: join the army and removing blood stasis, dry diabetes involving middle-JIAO food, HUOXUEHEXUE.Control red white dysentery, traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Buddlejae Butterflybush: [another name] MANSHANXIANG.[source] medical material Ji Yuan: be root, the leaf of Pittosporaceae plant platform Qionghai paulownia.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances dysentery relieving.Main traumatic injury, dysentery.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": QI and blood regulating, logical menstruation.2. " Traditional Chinese Medicine in Sichuan will ": activating blood circulation.[extracts] " China's book on Chinese herbal medicine "

Lacca: [source] medical material Ji Yuan: be the dry colloid that Lacciferidae animal lac insect is secreted on branch.[nature and flavor] sweet in the mouth; Salty; Property is put down; [return through] lung; Liver Channel.[function cures mainly] heat clearing away; Removing heat from blood; Removing toxic substances.Djumah rash, macule are not saturating; Menorrhagia; Metrorrhagia; Skin infection; Eczema.[each discussion] 1. " herbal classic is met former ": purple ore deposit and Lacca.Ancient prescription treating disorders in five ZANG-organs pathogen, incised wound metrorrhagia, by hematocele, granulation promoting pain relieving.The special treatment of smallpox skin ulcer of moderns, has swollen merit of having invigorated blood circulation, and without the trouble that salty-cold work rushes down, its merit doubly to Radix Arnebiae (Radix Lithospermi), therefore exhales it with Lacca, and real non-Radix Arnebiae (Radix Lithospermi) is also similar.3. Tang Materia Medica: main the five internal organs pathogen, leukorrhagia, pained, removing mass blood, gold creation meat.[extracts] " China's book on Chinese herbal medicine "

Flos persicae: [source] medical material Ji Yuan: be the flower of rosaceous plant Fructus Persicae or Prunus davidiana.[nature and flavor] are bitter; Flat; [return through] heart; Liver; Large intestine channel.[function cures mainly] diuretic; Blood circulation promoting and blood stasis dispelling.Main edema; Foot gas; Phlegm retention; Diuretic relieving constipation; Stranguria dne to urolithiasis; Constipation; Amenorrhea; Demented; Skin ulcer rash; [each discussion] " book on Chinese herbal medicine converges and says ": broken married woman's blood closes abdominal mass due to blood stasis, and blood wind is demented.[extracts] " China's book on Chinese herbal medicine "

Radix et Rhizoma Dysosmatis: [source] medical material Ji Yuan: be the root and rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis, Dysosma Pleiantha and dysosma veitchii Fu.[nature and flavor] bitter in the mouth; Pungent; Cool in nature; [return through] lung; Liver Channel.[function cures mainly] dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Main cough; Laryngopharynx swelling and pain; Scrofula; Goiter; Carbuncle; Furuncle; Venom; Traumatic injury harm; Arthromyodynia.[extracts] " China's book on Chinese herbal medicine "

Radix Seu Caulis Mucunae Sempervirentis: [source] medical material Ji Yuan: be the stem of the evergreen mucuna of leguminous plant.[nature and flavor] are bitter; Micro-hardship; Warm in nature; [return through] liver; Stomach warp.[function cures mainly] promoting blood flow to regulate menstruation; To enrich blood relaxing muscles and tendons.Main menoxenia; Dysmenorrhea; Amenorrhea; Puerperal blood deficiency; Anemia; Rheumatic arthralgia; Numb limbs and tense tendons; Traumatic injury.[each discussion] be " vegetation is side just " 1.: blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons, sharp joint.Control pain along the spinal column.2. " classify herbal ": control cold chronic infantile convulsion due to dysfunction of the spleen, rheumatic numbness, bones and muscles pain, detumescence.3. Jiangxi " medical herbs handbook ": control women's amenorrhea, knee osteodynia.[extracts] " China's book on Chinese herbal medicine "

Radix achyranthis asperae (Herba Achyranthis Asperae): [source] medical material Ji Yuan: be the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.[nature and flavor] are bitter; Acid; Cold nature; [return through] liver; Lung; Urinary bladder channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Inducing diuresis for treating stranguria syndrome; Clearing away heat and expelling pathogen in the exterior.Main warp closes; Dysmenorrhea; Menoxenia; Traumatic injury; Rheumatic arthritis; Gonorrhea; Edema; Damp-heat vaginal discharge, fever caused by exogenous pathogens; Malaria; Pharyngalgia; Furuncle carbuncle.[each discussion] 1. " Guangxi Chinese medicinal herbal ": diuresis, purifies the blood, sterilization.Control red-white dysentery, larynx disease, traumatic injury, strengthening bone and muscle, loose blood, pain relieving, reason beriberi [extracts] " China's book on Chinese herbal medicine "

Rhizoma Rhodiolae kirilowii: [another name] Radix Rhodiolae, Herba Senecionis Chrysanthemoidis.[source] medical material Ji Yuan: be rhizome and the root of crassulaceae plants Rhodiola kirilowii (Regel) Maxim..[nature and flavor] are bitter; Puckery; Temperature; [return through] liver; Kidney channel.[function cures mainly] tranquilizing by nourishing the heart; Blood circulation promoting and blood stasis dispelling; Hemostasis; Heat-clearing and toxic substances removing.Main deficiency of vital energy and physically weak; Lose heart weak; Palpitation and insomnia; Dizzy dizzy; Pain uncomfortable in chest; Traumatic injury; Menoxenia; Metrorrhagia; Spit blood; Dysentery; Diarrhoea.[extracts] " China's book on Chinese herbal medicine "

Maifanitum: [source] medical material Ji Yuan: be Acid-intermediate igneous rock rocks beschtauite.[nature and flavor] are sweet; Temperature; Nontoxic; [return through] liver; Stomach; Kidney channel.[function cures mainly] detoxicating and resolving stagnation of pathogens; Removing the necrotic tissue and promoting granulation; Except cold damp eliminating; The liver benefiting stomach invigorating; Blood circulation promoting and blood stasis dispelling; Diuresis fossil; Life lengthening.Main carbuncle carbuncle on the back; Acne; Eczema; Foot gas; Miliaria; Finger is chapped; Chloasma; Toothache; Oral ulcer; Rheumatic arthralgia; Lumbago and backache; Chronic hepatitis; Gastritis; Dysentery; Diabetes; Neurasthenia; Wound is red and swollen; Hypertension; Senile sclerosis of blood vessels; Tumor; Lithangiuria.[extracts] " China's book on Chinese herbal medicine "

Herba Sambuci Chiensis: [source] medical material Ji Yuan: be the stem and leaf of caprifoliaceae plant Herba Sambuci Chiensis.[nature and flavor] sweet in the mouth; Micro-hardship; Property is put down.[function cures mainly] dispels the wind; Dampness removing; Relaxing muscles and tendons; Invigorate blood circulation.Main air temperature arthralgia pain; Lumbago and skelalgia; Edema; Jaundice; Traumatic injury button damages; Disease that postpartum lochia can't go; Rubella pruritus; Erysipelas; Skin ulcer swells.[extracts] " China's book on Chinese herbal medicine "

Caulis Capsici: [another name] hot pepper obstructs.[source] medical material Ji Yuan: be the stem of solanaceae plant pepper.[nature and flavor] acrid in the mouth; Sweet; Hot in nature.[function cures mainly] dispelling cold and removing dampness; Blood circulation promoting and blood stasis dispelling.The clammy pain of main air; Freeze.[extracts] " China's book on Chinese herbal medicine "

SANYE Hydrocotyle vulgaris L.: [source] medical material Ji Yuan: be the herb of Oxalidaceae plant Herba Oxalis acetosellae.[nature and flavor] sour in the mouth; Micro-pungent; Property is put down; [return through] heart; Liver; Urinary bladder channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Heat-clearing and toxic substances removing; Inducing diuresis for treating stranguria syndrome.Main impairment caused by overstrain pain; Traumatic injury; Leprosy; Innominate toxic swelling; Scabies; Oral aphthae in children; Burn and scald; Stranguria with turbid discharge leukorrhagia; Urine retention.[extracts] " China's book on Chinese herbal medicine "

Radix corydalis linearioidis: [source] medical material Ji Yuan: be herb or the tuber of bloodroot lacinia Herba corydalis racemosae.[nature and flavor] are pungent; Micro-hardship; Flat; [return through] lung; Liver Channel.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Skin pruritus; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Hylotelephium verticillatum (Linn.) H. Ohba: [source] medical material Ji Yuan: be the herb of crassulaceae plants Hylotelephium verticillatum (Linn.) H. Ohba.[nature and flavor] are bitter; Cool.[function cures mainly] blood circulation promoting and blood stasis dispelling; Removing toxic substances and promoting subsidence of swelling.Main impairment caused by overstrain lumbago; Gold creates blood; Nameless gall; Snake bite and insect sting.[extracts] " China's book on Chinese herbal medicine "

Radix Daphniphylli calycini: [source] medical material Ji Yuan: be the root of Daphniphyllaceae plant Daphniphyllum calycinum.[nature and flavor] acrid in the mouth; Bitter; Cool in nature; [return through] lung; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main fever caused by exogenous pathogens; Cough; Laryngopharynx swelling and pain; The lower mass in the abdomen of the side of body; Rheumatic ostalgia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Cortex Ulmi virgatae: [source] medical material Ji Yuan: be the bark of Ulmaceae hair elm.[nature and flavor] are bitter; Puckery; Property is put down.[function cures mainly] blood circulation promoting and blood stasis dispelling; Hemostasis and pain-relieving.Main fracture; Traumatic pain; Traumatic hemorrhage; Gastrointestinal hemorrhage; Hematuria.[extracts] " China's book on Chinese herbal medicine "

Radix Aristolochiae: [source] this product is the dry root of aristolochiaceae plant Fructus Aristolochiae.[nature and flavor] are pungent, bitter, cold.[return through] attaches to the lung and stomach meridians.The pain relieving of [function cures mainly] suppressing the hyperactive liver, removing toxic substances and promoting subsidence of swelling.For dizziness and headache, chest and abdomen swelling and pain, carbuncle furuncle, snake bite and insect sting.[extracts] " Chinese Pharmacopoeia "

Semen Aesculi: [another name] SEMEN AESCULI.[source] this product is the dry mature seed of Hippocastanaceae plant Aesculus chinensis Bunge, Radix Aesculi or Aesculus.[nature and flavor] are sweet, temperature.[return through] returns liver, stomach warp.[function cures mainly] regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia.[extracts] " Chinese Pharmacopoeia "

Flos Citri Sarcodactylis: [another name] Buddhist Citrus chachiensis Hort..[source] medical material Ji Yuan: be flower and the alabastrum of rutaceae Fructus Citri Sarcodactylis.[nature and flavor] micro-hardship; Tepor; [return through] liver; Stomach warp.[function cures mainly] depressed liver-energy dispersing and QI regulating; Stomach function regulating soon every.Main stomachache due to hyperactive liver-QI attacking the stomach; Inappetence.[each discussion] " medical material compilation of data ": suppressing the hyperactive liver peratodynia.[extracts] " China's book on Chinese herbal medicine "

Semen Citri grandis: [source] medical material Ji Yuan: be the seed of Citrus paradisi Macfadyen.[nature and flavor] are bitter; Flat; Temperature; [return through] Liver Channel.[function cures mainly] depressed liver-energy dispersing and QI regulating; Lung qi dispersing cough-relieving.Main hernia lung cold cough.[extracts] " China's book on Chinese herbal medicine "

Bulbus Allii Macrostemonis: [another name] wild Chinese onion, Herba Allii prattii, Bulbus Allii Macrostemonis head, Chinese wild onion.[source] this product is the dry bulb of liliaceous plant Allium macrostemon or Chinese onion.[nature and flavor] are pungent, bitter, temperature.[return through] returns lung, stomach, large intestine channel.[function cures mainly] activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.[extracts] " Chinese Pharmacopoeia "

Radix Et Rhizoma Nardostachyos: [another name] Nardostachys chinensis Batal..[source] this product is the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos or spoon Ye Gansong.[nature and flavor] acrid, sweet, warm.[return through] returns spleen, stomach warp.[function cures mainly] regulating QI to relieve pain, relieving stagnation and activating the spleen.For distension and fullness in the abdomen, inappetence, vomiting; External treatment is had a toothache, swelling of the feet.[extracts] " Chinese Pharmacopoeia "

Folium Perillae: [another name] Folium Perillae .[originates] this product is the dried leaves (or band twig) of labiate Folium Perillae.[nature and flavor] are pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] induces sweat cold expelling, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.[extracts] " Chinese Pharmacopoeia "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Radix aconiti sinomontani 10 ~ 25 parts, 15 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 10 ~ 20 parts, Lacca 10 ~ 30 parts, 10 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 10 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 15 ~ 30 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 ~ 25 parts, Rhizoma Rhodiolae kirilowii 10 ~ 30 parts, Maifanitum 10 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 20 parts, Caulis Capsici 15 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 15 ~ 30 parts, Radix corydalis linearioidis 10 ~ 30 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 25 parts, Radix Daphniphylli calycini 10 ~ 25 parts, Cortex Ulmi virgatae 10 ~ 20 parts, Radix Aristolochiae 10 ~ 30 parts, Semen Aesculi 10 ~ 30 parts, Flos Citri Sarcodactylis 10 ~ 20 parts, Semen Citri grandis 15 ~ 25 parts, Bulbus Allii Macrostemonis 10 ~ 25 parts, Radix Et Rhizoma Nardostachyos 10 ~ 20 parts and Folium Perillae 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Radix aconiti sinomontani 10 ~ 15 parts, 20 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 15 ~ 20 parts, Lacca 15 ~ 25 parts, 15 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 15 ~ 20 parts, Radix Seu Caulis Mucunae Sempervirentis 20 ~ 25 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Rhizoma Rhodiolae kirilowii 20 ~ 30 parts, Maifanitum 20 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 15 parts, Caulis Capsici 20 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 20 ~ 30 parts, Radix corydalis linearioidis 15 ~ 25 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 15 parts, Radix Daphniphylli calycini 15 ~ 20 parts, Cortex Ulmi virgatae 15 ~ 20 parts, Radix Aristolochiae 20 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Flos Citri Sarcodactylis 15 ~ 20 parts, Semen Citri grandis 20 ~ 25 parts, Bulbus Allii Macrostemonis 15 ~ 25 parts, Radix Et Rhizoma Nardostachyos 15 ~ 20 parts and Folium Perillae 20 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Radix aconiti sinomontani 13 parts, 23 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 18 parts, Lacca 20 parts, 21 parts, Flos persicae, Radix et Rhizoma Dysosmatis 18 parts, Radix Seu Caulis Mucunae Sempervirentis 22 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Rhizoma Rhodiolae kirilowii 25 parts, Maifanitum 26 parts, Herba Sambuci Chiensis 15 parts, Caulis Capsici 27 parts, SANYE Hydrocotyle vulgaris L. 25 parts, Radix corydalis linearioidis 23 parts, Hylotelephium verticillatum (Linn.) H. Ohba 13 parts, Radix Daphniphylli calycini 18 parts, Cortex Ulmi virgatae 16 parts, Radix Aristolochiae 25 parts, Semen Aesculi 20 parts, Flos Citri Sarcodactylis 15 parts, Semen Citri grandis 22 parts, Bulbus Allii Macrostemonis 20 parts, Radix Et Rhizoma Nardostachyos 18 parts and Folium Perillae 20 parts.

The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment endometriosis interna, and the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment endometriosis interna, and the dosage form of described Chinese medicine is granule, and it comprises the following steps:

The first step, Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis and Radix achyranthis asperae (Herba Achyranthis Asperae) are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Sambuci Chiensis, Caulis Capsici, Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini and Radix Aristolochiae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule prepared by the present invention

Get Radix aconiti sinomontani 130g, Monas cuspurpureus Went 230g, Radix Buddlejae Butterflybush 180g, Lacca 200g, Flos persicae 210g, Radix et Rhizoma Dysosmatis 180g, Radix Seu Caulis Mucunae Sempervirentis 220g, Radix achyranthis asperae (Herba Achyranthis Asperae) 180g, Rhizoma Rhodiolae kirilowii 250g, Maifanitum 260g, Herba Sambuci Chiensis 150g, Caulis Capsici 270g, SANYE Hydrocotyle vulgaris L. 250g, Radix corydalis linearioidis 230g, Hylotelephium verticillatum (Linn.) H. Ohba 130g, Radix Daphniphylli calycini 180g, Cortex Ulmi virgatae 160g, Radix Aristolochiae 250g, Semen Aesculi 200g, Flos Citri Sarcodactylis 150g, Semen Citri grandis 220g, Bulbus Allii Macrostemonis 200g, Radix Et Rhizoma Nardostachyos 180g and Folium Perillae 200g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2: capsule prepared by the present invention

Get Radix aconiti sinomontani 110g, Monas cuspurpureus Went 250g, Radix Buddlejae Butterflybush 160g, Lacca 230g, Flos persicae 180g, Radix et Rhizoma Dysosmatis 160g, Radix Seu Caulis Mucunae Sempervirentis 240g, Radix achyranthis asperae (Herba Achyranthis Asperae) 150g, Rhizoma Rhodiolae kirilowii 280g, Maifanitum 320g, Herba Sambuci Chiensis 120g, Caulis Capsici 330g, SANYE Hydrocotyle vulgaris L. 220g, Radix corydalis linearioidis 160g, Hylotelephium verticillatum (Linn.) H. Ohba 110g, Radix Daphniphylli calycini 170g, Cortex Ulmi virgatae 190g, Radix Aristolochiae 280g, Semen Aesculi 170g, Flos Citri Sarcodactylis 180g, Semen Citri grandis 240g, Bulbus Allii Macrostemonis 160g, Radix Et Rhizoma Nardostachyos 170g and Folium Perillae 230g.

Its preparation method comprises the following steps:

The first step, Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis and Radix achyranthis asperae (Herba Achyranthis Asperae) are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 85 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Herba Sambuci Chiensis, Caulis Capsici, Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini and Radix Aristolochiae are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 24-32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.63g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.15 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>43.15 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.3 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.35g crude drug/day/people, adult body weight in 60KG, average dosage is 0.139g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 28g) oral administration gavage Chinese medicine of the present invention is 621 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.23,25.35 and 42.27g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all cases all derive from this Out-patient Department and inpatient, totally 118 examples, be divided into treatment group (72 example) and matched group (70 example) at random.In treatment group 59 example, age 25-48 year, course of disease 1-6.Matched group 59 example, age 25-50 year, course of disease 1-6.Treatment group group and matched group no significant difference on age and clinical symptoms, two groups of data comparing difference not statistically significants (P > 0.05), have comparability.

Diagnostic criteria: with reference to the diagnostic criteria of " new Chinese medicine guideline of clinical investigations " (the 1st phase) endometriosis that Ministry of Health of the People's Republic of China issues.Primary symptom: premenstrual menstrual period lumbosacral region, distention and pain in the lower abdomen or discomfort aggravate gradually.Secondary disease: abdominal pain alleviated by pressure, dysmenorrhoea draws waist sacrum, and pain is very fainted; Light and dull menses, matter is rare or accompany clot, alleviation of pain under block; Poor appetite loose stool, spiritlessness and weakness, lusterless complexion; Dyspareunia; Rectal tenesmus.Tongue arteries and veins: light red tongue is dim, while there is tooth to print, petechia ecchymosis, white and thin fur, thready pulse or carefully puckery.There is above primary symptom, 2 of secondary disease and the performance of tongue arteries and veins and diagnosable.

Therapeutic Method:

Treatment group: oral Chinese medicine embodiment 1 granule of the present invention, each 15g, every day 3 times.Within one month, be a course for the treatment of, be used in conjunction three courses for the treatment of.

Matched group: oral danazol capsule, each 200mg, every day 2 times three months is a course for the treatment of.

Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment endometriosis interna.

Curative effect judging standard: (1) fully recovers: symptom all disappears, the local such as pelvic lump sign disappears substantially; Infertile patient is gestation or fertility in 1 year.(2) effective: symptom disappears substantially, pelvic lump reduces (the menstrual cycle same time checks contrast, the contrast of same time B ultrasonic before and after treatment); Local sign exists, but infertile patient is become pregnant.(3) effective: symptom alleviates, pelvic lump is without increase or slightly reduce, and in drug withdrawal 3 months, symptom does not increase the weight of.(4) invalid: cardinal symptom is unchanged or worsen, and local patholoic change has and increases the weight of trend.

Therapeutic outcome: treat 3 months respectively for two groups, the tracking then carrying out 3-9 month is respectively followed up a case by regular visits to, and statistical result is see table 1.

Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Treatment group	59	13	30	13	3	56(94.92％)
Matched group	59	7	18	23	11	48(81.36％)

As can be seen from Table 1, adopt treatment by Chinese herbs endometriosis interna of the present invention, relative to matched group on therapeutic effect, there is significant improvement.

Concrete case: patient, female, 46 years old, on January 6th, 2013 comes to go to a doctor, private prosecution endometriosis 4 years half, on inspection: premenstrual menstrual period distention and pain in the lower abdomen, dysmenorrhoea unbearably, light and dull menses, accompany clot, spiritlessness and weakness, lusterless complexion, dyspareunia, light red tongue is dim, while there is tooth to print, and white and thin fur, thready pulse, is diagnosed as endometriosis interna.The granule of oral administration inventive embodiments 1, each 15g, every day 3 times, take the 10th day below color improve, sense disappearance tired out, after 30 days, through period dysmenorrhoea obviously alleviate, normal through color.After treating a course for the treatment of, have rosy cheeks, slight dysmenorrhea, the eumenorrhea, abdominal distention stomachache disappears, and continues two weeks drug withdrawal of taking medicine, recovery from illness, follows up a case by regular visits to 3 months without recurrence.

Claims (8)

1. treat the Chinese medicine of endometriosis interna for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis, Radix achyranthis asperae (Herba Achyranthis Asperae), Rhizoma Rhodiolae kirilowii, Maifanitum, Herba Sambuci Chiensis, Caulis Capsici, SANYE Hydrocotyle vulgaris L., Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini, Cortex Ulmi virgatae, Radix Aristolochiae, Semen Aesculi, Flos Citri Sarcodactylis, Semen Citri grandis, Bulbus Allii Macrostemonis, Radix Et Rhizoma Nardostachyos and Folium Perillae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix aconiti sinomontani 10 ~ 25 parts, 15 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 10 ~ 20 parts, Lacca 10 ~ 30 parts, 10 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 10 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 15 ~ 30 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 ~ 25 parts, Rhizoma Rhodiolae kirilowii 10 ~ 30 parts, Maifanitum 10 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 20 parts, Caulis Capsici 15 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 15 ~ 30 parts, Radix corydalis linearioidis 10 ~ 30 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 25 parts, Radix Daphniphylli calycini 10 ~ 25 parts, Cortex Ulmi virgatae 10 ~ 20 parts, Radix Aristolochiae 10 ~ 30 parts, Semen Aesculi 10 ~ 30 parts, Flos Citri Sarcodactylis 10 ~ 20 parts, Semen Citri grandis 15 ~ 25 parts, Bulbus Allii Macrostemonis 10 ~ 25 parts, Radix Et Rhizoma Nardostachyos 10 ~ 20 parts and Folium Perillae 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix aconiti sinomontani 10 ~ 15 parts, 20 ~ 25 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 15 ~ 20 parts, Lacca 15 ~ 25 parts, 15 ~ 25 parts, Flos persicae, Radix et Rhizoma Dysosmatis 15 ~ 20 parts, Radix Seu Caulis Mucunae Sempervirentis 20 ~ 25 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Rhizoma Rhodiolae kirilowii 20 ~ 30 parts, Maifanitum 20 ~ 35 parts, Herba Sambuci Chiensis 10 ~ 15 parts, Caulis Capsici 20 ~ 35 parts, SANYE Hydrocotyle vulgaris L. 20 ~ 30 parts, Radix corydalis linearioidis 15 ~ 25 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 ~ 15 parts, Radix Daphniphylli calycini 15 ~ 20 parts, Cortex Ulmi virgatae 15 ~ 20 parts, Radix Aristolochiae 20 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Flos Citri Sarcodactylis 15 ~ 20 parts, Semen Citri grandis 20 ~ 25 parts, Bulbus Allii Macrostemonis 15 ~ 25 parts, Radix Et Rhizoma Nardostachyos 15 ~ 20 parts and Folium Perillae 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix aconiti sinomontani 13 parts, 23 parts, Monas cuspurpureus Went, Radix Buddlejae Butterflybush 18 parts, Lacca 20 parts, 21 parts, Flos persicae, Radix et Rhizoma Dysosmatis 18 parts, Radix Seu Caulis Mucunae Sempervirentis 22 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Rhizoma Rhodiolae kirilowii 25 parts, Maifanitum 26 parts, Herba Sambuci Chiensis 15 parts, Caulis Capsici 27 parts, SANYE Hydrocotyle vulgaris L. 25 parts, Radix corydalis linearioidis 23 parts, Hylotelephium verticillatum (Linn.) H. Ohba 13 parts, Radix Daphniphylli calycini 18 parts, Cortex Ulmi virgatae 16 parts, Radix Aristolochiae 25 parts, Semen Aesculi 20 parts, Flos Citri Sarcodactylis 15 parts, Semen Citri grandis 22 parts, Bulbus Allii Macrostemonis 20 parts, Radix Et Rhizoma Nardostachyos 18 parts and Folium Perillae 20 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis and Radix achyranthis asperae (Herba Achyranthis Asperae) are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Sambuci Chiensis, Caulis Capsici, Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini and Radix Aristolochiae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

7. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, Radix aconiti sinomontani, Monas cuspurpureus Went, Radix Buddlejae Butterflybush, Lacca, Flos persicae, Radix et Rhizoma Dysosmatis, Radix Seu Caulis Mucunae Sempervirentis and Radix achyranthis asperae (Herba Achyranthis Asperae) are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Sambuci Chiensis, Caulis Capsici, Radix corydalis linearioidis, Hylotelephium verticillatum (Linn.) H. Ohba, Radix Daphniphylli calycini and Radix Aristolochiae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.