CN100431593C - Chinese medicinal formulation for treating hydrocephalus - Google Patents

Chinese medicinal formulation for treating hydrocephalus Download PDF

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Publication number
CN100431593C
CN100431593C CNB2006101145465A CN200610114546A CN100431593C CN 100431593 C CN100431593 C CN 100431593C CN B2006101145465 A CNB2006101145465 A CN B2006101145465A CN 200610114546 A CN200610114546 A CN 200610114546A CN 100431593 C CN100431593 C CN 100431593C
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parts
stir
salt solution
baked
polyporus
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CN1961951A (en
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王信锁
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BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
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BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
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Abstract

The invention relates to a Chinese medicinal preparation for treating hydrocrania, which is prepared from raw materials of deer horn, eucommia bark, bitter cardamon, batryticated silkworm, achyranthes and cyathula root, grassleaved sweetflag rhizome, polyporus umbellatus, polygala root and plantain seed, and has the actions of tonifying liver and kidney, excreting dampness, arousing coma, tranquillizing mind and developing intelligence.

Description

The hydrocephalic Chinese medicine preparation of a kind of treatment
Technical field
The present invention relates to the hydrocephalic Chinese medicine preparation of a kind of treatment, is that a kind of hydrocephalus for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Hydrocephalus is meant that the intracranial hypertension and the ventricles of the brain that cerebrospinal fluid circulation disorder causes enlarge.Cerebrospinal fluid circulation disorder occurs in ventricular system or exit, ventriculus quartus, the ventricular system that causes blocking near-end enlarges, and claims " obstructive hydrocephalus " to be more common in congenital brain development deformity or struvite adhesion and long in Intraventricular or contiguous ependymoma and glioma.Hydrocephalic cardinal symptom is relevant with intracranial hypertension with sign.Mental retardation, epilepsy etc. can also appear in the child.Clinical manifestation and general intracranial hypertension are identical, mainly show as headache, vomiting, the symptom of papilloedema and primary disease.Hydrocephalus can occur at any age, mostly took place in giving birth in back 6 months, and little infant skull suture of age is still not closed, and head enlarges easily, and the symptom of intracranial hypertension is lighter.The outstanding symptom of hydrocephalus is that head is very big, and the speed that increases is very fast, and that kowtows is " broken kettle sound ", and the order pearl is sagging just as " setting sun shape ", and mental deficiency etc. are main clinical manifestation.Generally divide two types of obstructive and traffic clinically, belong to the traditional Chinese medical science " infantile metopism ", " halogen is filled out " category.
The traditional Chinese medical science is thought hydrocephalus mainly due to the fetus innate deficiency, due to the kidney qi loss; Or because of after the serious disease prolonged illness, the kidney yin consume, or because of lacking of proper care after one's birth, insufficiency of the spleen wet general, flaming up of liver-fire, the marrow pyretic toxicity is stopped up so that the long-pending brain network of water forms.Its sick position is at brain, and ordinary wave reaches in the heart, liver,spleen,kidney etc.Clinical all with the head increase, bregma expansion or protrusion etc. are cardinal symptom.But according to clinical findings " infantile metopism ", in the majority with deficient syndrome, " halogen is filled out " sees that with excess syndrome the traditional Chinese medical science is divided into more: kidney qi loss, insufficiency of the spleen water are general, deficiency of YIN marrow heat, pyretic toxicity are stopped up knot, water stasis of blood disease type Coryza Treated by Syndrome Differentiation such as knot mutually.The method of western medical treatment primary disease is a lot, but great majority can only reach recent clinical effectiveness, and can not prevent recurrence, and has toxic and side effects in various degree.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the hydrocephalic Chinese medicine preparation of a kind of treatment, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
0.1~2.0 part of 0.5~3.0 part of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.0~4.0 parts of Cortex Eucommiae of Colla Cornus Cervi
1.0~4.0 parts of 0.5~3.0 part of salt Radix Cyathulaes of 0.1~2.0 part of Rhizoma Acori Graminei of Bombyx Batryticatus
1.5~6.0 parts of 0.1~2.0 part of stir-baked SEMEN PLANTAGINIS with salt solution of 1.5~6.0 parts of Radix Polygalae (processed) of Polyporus
The weight proportion of each raw material of optimization formula of the present invention is:
0.5~1.5 part of 1.0~2.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.5~2.5 parts of Cortex Eucommiae of Colla Cornus Cervi
1.5~2.5 parts of 1.0~2.0 parts of salt Radix Cyathulaes of 0.5~1.5 part of Rhizoma Acori Graminei of Bombyx Batryticatus
2.5~3.5 parts of 0.5~1.5 part of stir-baked SEMEN PLANTAGINIS with salt solution of 2.5~3.5 parts of Radix Polygalae (processed) of Polyporus
The weight proportion of each raw material of optimum formula of the present invention is:
1 part of 1.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2 parts of Cortex Eucommiae of Colla Cornus Cervi
2 parts of 1.5 parts of salt Radix Cyathulaes of 1 part of Rhizoma Acori Graminei of Bombyx Batryticatus
3 parts of 1.0 parts of stir-baked SEMEN PLANTAGINIS with salt solution of 3 parts of Radix Polygalae (processed) of Polyporus
Drug action mechanism among the present invention is as follows:
The Colla Cornus Cervi nature and flavor are salty, temperature.Return liver, kidney channel.Has the kidney warming sun, bone and muscle strengthening, promoting the circulation of blood repercussive effect.Can treat impotence and seminal emission, the spinal column cold type of pain, the carbuncle of yin nature skin infection, acute mastitis is from the beginning of, swelling and pain due to blood stasis etc.(the 264th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Cortex Eucommiae nature and flavor are sweet, wet.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.Can treat hypertension and doublely suffer from a deficiency of the kidney, back ache, foot and knee flaccidity, dribbling urination, uncontrolled urination are itched, vaginal bleeding during pregnancy is desired to fall, have a dizzy spell, frequent fetal movement etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 623rd page).
Stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution nature and flavor suffering, temperature.Return spleen, kidney channel.Have warming spleen and stopping diarrha, the effect of warming the kidney controlling nocturnal emission with astringent drugs reducing urination.Can treat that spleen-cold syndrome is had loose bowels, cold type of pain in the abdomen, mouthful slaver over more, enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1048th page).
Bombyx Batryticatus nature and flavor suffering is salty, flat.Return liver, lung, stomach warp.Effect with expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Can treat apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis etc." Chinese medicine voluminous dictionary " the 739th page.
Salt Radix Cyathulae property is flat, and sweet and slightly bitter taste is nontoxic.Return liver, kidney channel.Have dispel the wind, dampness removing, the effect of stimulating the menstrual flow, invigorating blood circulation.Can treat rheumatism lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, lump in the abdomen etc." Chinese medicine voluminous dictionary " the 228th page.
Rhizoma Acori Graminei nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Have removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, ward off dirty parasite killing, blood pressure lowering, spasmolytic, anti-inflammation, the effect of detoxifying, regulate the flow of vital energy, invigorating blood circulation.Can treat epilepsy, expectorant febrile convulsion, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, anemofrigid-damp arthralgia, stomachache, distension and fullness in the abdomen, enteritis, dysentery, chronic bronchitis, infantile pneumonia, sputum obturation, obnubilation, carbuncle tinea scabies, traumatic injury etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 399th page).
The Polyporus nature and flavor are sweet, light, flat.Return spleen, kidney, urinary bladder channel.Have diuresis eliminating dampness by diuresis, anticancer effect.Can treat dysuria, edema distension, beriberi, urinary system infection, diarrhoea, stranguria with turbid discharge, leukorrhagia etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1122nd page).
Radix Polygalae (processed) nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.It is swollen etc. to treat phlegm retention, coma, cough, insomnia, palpitation with fear, forgetful, nocturnal emission, carbuncle skin ulcer.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 620th page).
The stir-baked SEMEN PLANTAGINIS with salt solution nature and flavor are sweet, be slightly cold.Return liver, kidney, lung, small intestinal, urinary bladder channel.Has clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, the effect of removing heat from the lung and dissipating phlegm.Can treat the cough due to lung-heat, urinary system infection, calculus, gastritis, dysuria, enteritis, bacillary dysentery, acute icterohepatitisshock, bronchitis, acute eye conjunctivitis, stranguria with turbid discharge, leukorrhagia, hematuria, edema, hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis, cough, skin ulcer etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 291st page).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Colla Cornus Cervi, Cortex Eucommiae, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution and Bombyx Batryticatus, is ministerial drug with salt Radix Cyathulae, Rhizoma Acori Graminei and Polyporus, is adjuvant with Radix Polygalae (processed) and stir-baked SEMEN PLANTAGINIS with salt solution.All medicine phases and the effect that is total to tool temperature compensation Liver and kidney, promoting diuresis to eliminate damp pathogen, the eliminating phlegm of having one's ideas straightened out, the Fructus Alpiniae Oxyphyllae of calming the nerves, the treatment hydrocephalus has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as; Tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment hydrocephalus of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention not only can effectively treat hydrocephalus, and hydrocephalic prevention is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.
Hydrocephalus (infantile metopism) curative effect determinate standard: (the 559th page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).
1, cure: head stops to increase, and bregma, sutura cranii gradually close.Imputability.
2, take a turn for the better: head stops to increase, and bregma, sutura cranii obviously shrink, and it is clear that look is changeed.
3, do not heal: head continues to increase, and symptom is on the rise.
Further specify medicine of the present invention to treating hydrocephalic therapeutic effect below by the clinical practice example
As follows through clinical test results; Treatment hydrocephalic 28 examples.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 15 examples and account for 53.5%, 11 examples that take a turn for the better account for 39.2%, and more 2 examples do not account for 7.1%, and total effective rate reaches 92.9%.After three course of therapy, patient's head stops to increase, and bregma, sutura cranii obviously shrink, and it is clear that look is changeed.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
1 part of 1.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2 parts of Cortex Eucommiae of Colla Cornus Cervi
2 parts of 1.5 parts of salt Radix Cyathulaes of 1 part of Rhizoma Acori Graminei of Bombyx Batryticatus
3 parts of 1.0 parts of stir-baked SEMEN PLANTAGINIS with salt solution of 3 parts of Radix Polygalae (processed) of Polyporus
Preparation method is to get Colla Cornus Cervi drying and crushing to 120~200 order fine powders earlier, get Cortex Eucommiae again, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, Bombyx Batryticatus, the salt Radix Cyathulae, Rhizoma Acori Graminei, Polyporus, Radix Polygalae (processed) and stir-baked SEMEN PLANTAGINIS with salt solution decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Colla Cornus Cervi fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
1 part of 1.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2 parts of Cortex Eucommiae of Colla Cornus Cervi
2 parts of 1.5 parts of salt Radix Cyathulaes of 1 part of Rhizoma Acori Graminei of Bombyx Batryticatus
3 parts of 1.0 parts of stir-baked SEMEN PLANTAGINIS with salt solution of 3 parts of Radix Polygalae (processed) of Polyporus
Preparation method is to get Colla Cornus Cervi drying and crushing to 120~200 order fine powders earlier, get Cortex Eucommiae again, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, Bombyx Batryticatus, the salt Radix Cyathulae, Rhizoma Acori Graminei, Polyporus, Radix Polygalae (processed) and stir-baked SEMEN PLANTAGINIS with salt solution decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Colla Cornus Cervi fine powder mixing, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
1 part of 1.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2 parts of Cortex Eucommiae of Colla Cornus Cervi
2 parts of 1.5 parts of salt Radix Cyathulaes of 1 part of Rhizoma Acori Graminei of Bombyx Batryticatus
3 parts of 1.0 parts of stir-baked SEMEN PLANTAGINIS with salt solution of 3 parts of Radix Polygalae (processed) of Polyporus
Preparation method is to get Colla Cornus Cervi drying and crushing to 120~200 order fine powders earlier, get Cortex Eucommiae again, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, Bombyx Batryticatus, the salt Radix Cyathulae, Rhizoma Acori Graminei, Polyporus, Radix Polygalae (processed) and stir-baked SEMEN PLANTAGINIS with salt solution decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Colla Cornus Cervi fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, one month is a course of treatment.

Claims (3)

1, the hydrocephalic Chinese medicine preparation of a kind of treatment is characterized in that it is made by following raw materials by weight proportions:
0.1~2.0 part of 0.5~3.0 part of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.0~4.0 parts of Cortex Eucommiae of Colla Cornus Cervi
1.0~4.0 parts of 0.5~3.0 part of salt Radix Cyathulaes of 0.1~2.0 part of Rhizoma Acori Graminei of Bombyx Batryticatus
1.5~6.0 parts of 0.1~2.0 part of stir-baked SEMEN PLANTAGINIS with salt solution of 1.5~6.0 parts of Radix Polygalae (processed) of Polyporus.
2, the hydrocephalic Chinese medicine preparation of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:
0.5~1.5 part of 1.0~2.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.5~2.5 parts of Cortex Eucommiae of Colla Cornus Cervi
1.5~2.5 parts of 1.0~2.0 parts of salt Radix Cyathulaes of 0.5~1.5 part of Rhizoma Acori Graminei of Bombyx Batryticatus
2.5~3.5 parts of 0.5~1.5 part of stir-baked SEMEN PLANTAGINIS with salt solution of 2.5~3.5 parts of Radix Polygalae (processed) of Polyporus.
3, the hydrocephalic Chinese medicine preparation of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:
1 part of 1.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2 parts of Cortex Eucommiae of Colla Cornus Cervi
2 parts of 1.5 parts of salt Radix Cyathulaes of 1 part of Rhizoma Acori Graminei of Bombyx Batryticatus
3 parts of 1.0 parts of stir-baked SEMEN PLANTAGINIS with salt solution of 3 parts of Radix Polygalae (processed) of Polyporus.
CNB2006101145465A 2006-11-15 2006-11-15 Chinese medicinal formulation for treating hydrocephalus Expired - Fee Related CN100431593C (en)

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721001A (en) * 2013-12-27 2014-04-16 孙敏 Traditional Chinese medicine preparation for treating pediatric hydrocephalus caused by yang deficiency and water overflowing
CN103768432B (en) * 2014-01-09 2016-04-13 李文香 A kind of Chinese medicine composition for the treatment of type of hyperactivity of fire caused by deficiency of YIN Children Hydrocephali
CN104398706A (en) * 2014-11-10 2015-03-11 李玉刚 External halogen-sealed patch for treating infant hydrocephalus and preparation method thereof
CN104306603A (en) * 2014-11-10 2015-01-28 李玉刚 Patch for external application for infant hydrocephalus and preparation method of patch
CN105770690A (en) * 2016-03-11 2016-07-20 王德亮 Medicament for treating hydrocephalus and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1634385A (en) * 2004-11-04 2005-07-06 谢静 Chinese traditional medicine composition for treating hydrocephalus, cerebral edema and intracranial hypertension
CN1650907A (en) * 2004-12-29 2005-08-10 文景社 Zhogkang pill

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1634385A (en) * 2004-11-04 2005-07-06 谢静 Chinese traditional medicine composition for treating hydrocephalus, cerebral edema and intracranial hypertension
CN1650907A (en) * 2004-12-29 2005-08-10 文景社 Zhogkang pill

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