Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the leukodermic Chinese medicine preparation of a kind of treatment, have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.5~6 parts of 2.5~10 parts of Rhizoma Chuanxiongs of 2.5~10 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
1.5~6 parts in 2.5~10 portions of Herba Spirodelaes of 1.5~6 parts of salt Rhizoma Drynariae of Radix Paeoniae Alba
1~4 part of 1.5~6 parts of Radix Saposhnikoviae of 2.5~10 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
1~4 part of 1.5~6 parts of Cortex Dictamni of 2.5~10 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
The weight proportion of each raw material of optimization formula of the present invention is:
2.5~3.5 parts of 3~7 parts of Rhizoma Chuanxiongs of 3~7 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
2.5~3.5 parts in 3~7 portions of Herba Spirodelaes of 2.5~3.5 parts of salt Rhizoma Drynariae of Radix Paeoniae Alba
1.5~2.5 parts of 2.5~3.5 parts of Radix Saposhnikoviaes of 3~7 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
1.5~2.5 parts of 2.5~3.5 parts of Cortex Dictamni of 3~7 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 5 parts of Rhizoma Chuanxiongs of 5 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
3 parts in 5 portions of Herba Spirodelaes of 3 parts of Rhizoma drynariae preparatas of Radix Paeoniae Alba
2 parts of 3 parts of Radix Saposhnikoviaes of 5 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
2 parts of 3 parts of Cortex Dictamni of 5 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
Drug action mechanism among the present invention is as follows:
The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).
Radix Paeoniae Alba nature and flavor hardship, acid, be slightly cold.Return liver, spleen channel.Effect with suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, antibiotic, thrombocytosis.Can treat that the pain over the hypochondriac region, dysentery stomachache, night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, headache are dizzy, limb pain twin, blood deficiency and yellow complexion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 432nd page).
The Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.What be used for that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).
Wine Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Can treat menoxenia, amenorrhea dysmenorrhea , lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris etc.(the 57th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Salt Semen Astragali Complanati nature and flavor are sweet, temperature.Return liver, kidney channel.Has the temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect that makes eye bright.Can treat lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision etc.(the 145th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Rhizoma drynariae preparata nature and flavor hardship, temperature.Return kidney, Liver Channel.Have the kidney invigorating bone strengthening, continuous hinder pain relieving, invigorate blood circulation, the hemostatic effect.Can treat osteocarcinoma, osteosarcoma, the chronic diarrhea of suffering from a deficiency of the kidney, lumbago, rheumatic arthralgia, Hiccough and deaf, odontoseisis, fall wink frustrate, muscles and bones wound, appendicitis, alopecia areata, clavus, vitiligo, congestion are had a pain, rheumatic arthritis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 930th page).
Stir-baked FRUCTUS TRIBULI nature and flavor suffering, hardship, tepor; Slightly poisonous.Return Liver Channel.Have the suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind makes eye bright, the itching relieving effect.It is dizzy to treat headache, distending pain in the chest and hypochondrium, and breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus etc.(the 289th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission)
The Radix Angelicae Sinensis (processed with wine) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).
Rhizoma Chuanxiong nature and flavor suffering, perfume (or spice).Return liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Can treat menoxenia, the amenorrhea dysmenorrhea, difficult labour produces stasis of blood stop block pain, lump in the abdomen stomachache, the twinge of the breast side of body, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, headache due to pathogenic wind-heat, rheumatic arthralgia, skin infection swells and ache, placenta retention, cerebral ischemia, coronary heart disease, angina pectoris, atherosclerosis, hypertension, radiotherapy, leukopenia due to the chemotherapy, juvenile myopia, vitamin e deficiency, flu is dizzy, external plug nose treating malaria disease etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 171st page).
Herba Spirodelae nature and flavor suffering, cold.Return lung meridian.Has dispelling wind-heat, rash, diuretic effect.Can treat measles without adequate eruption, rubella pruritus, edema oliguria etc.(the 243rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Radix Saposhnikoviae nature and flavor suffering, sweet, temperature.Return bladder, liver, spleen channel.Have inducing diaphoresis to dispel wind, win and wet, the effect of relieving convulsion.Can treat headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus etc.(the 117th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Cortex Dictamni nature and flavor hardship, cold.Return spleen, stomach, urinary bladder channel.Has heat clearing and damp drying, the antidotal effect of dispeling the wind.Can treat damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine etc.(the 83rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae, Radix Astragali, wine Radix Salviae Miltiorrhizae, salt Semen Astragali Complanati and salt Rhizoma Drynariae, and Radix Paeoniae Alba, stir-baked FRUCTUS TRIBULI, Radix Angelicae Sinensis (processed with wine), Herba Spirodelae and Cortex Dictamni are ministerial drug, and Rhizoma Chuanxiong and Radix Saposhnikoviae are adjuvant.All medicines mutually and have heat clearing and damp drying altogether, the detoxifcation of dispeling the wind, liver-smoothing, qi-regulating, the white effect that disappears of invigorating blood circulation, treatment and prevention vitiligo, determined curative effect has no side effect, taking convenience is cheap.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention vitiligo of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention not only can effectively treat vitiligo, and leukodermic prevention is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.
Further specify medicine of the present invention to treatment therapy for vitiligo effect below by the clinical practice example.
Vitiligo curative effect determinate standard (the 228th page of Chen Qin chief editor " research and development of Chinese medicine cosmetic health product " Chinese Medicine science and technology publishing house version in 1999.)
(1) recovery from illness: the white macula complete obiteration, histopathology of skin checks normal.
(2) produce effects: white macula disappears more than 50%, and white macula disappearance portion of tissue pathological examination is normal.
(3) effective: white macula disappearance person accounts for 20%~50% of former white macula area, or sees have than the polychrom island in white macula.
(4) invalid: no change or white macula enlarge before and after the treatment.
As follows through clinical test results; Treatment patients with vitiligo 56 examples, male's 24 examples, women's 32 examples, the age is 10~45 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.47 examples of fully recovering account for 83.9%, and produce effects 4 examples account for 7.14%, and effective 3 examples account for 5.35%, and invalid 2 examples account for 3.57%, and total effective rate reaches more than 96%.After three course of therapy, the patient skin white macula disappears in various degree or fully recovers.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
3 parts of 5 parts of Rhizoma Chuanxiongs of 5 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
3 parts in 5 portions of Herba Spirodelaes of 3 parts of Rhizoma drynariae preparatas of Radix Paeoniae Alba
2 parts of 3 parts of Radix Saposhnikoviaes of 5 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
2 parts of 3 parts of Cortex Dictamni of 5 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
Preparation method is to get Radix Rehmanniae, Radix Paeoniae Alba, Radix Astragali, wine Radix Salviae Miltiorrhizae, salt Semen Astragali Complanati, Rhizoma drynariae preparata, stir-baked FRUCTUS TRIBULI, Radix Angelicae Sinensis (processed with wine), Rhizoma Chuanxiong, Herba Spirodelae, Radix Saposhnikoviae and Cortex Dictamni to decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
3 parts of 5 parts of Rhizoma Chuanxiongs of 5 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
3 parts in 5 portions of Herba Spirodelaes of 3 parts of Rhizoma drynariae preparatas of Radix Paeoniae Alba
2 parts of 3 parts of Radix Saposhnikoviaes of 5 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
2 parts of 3 parts of Cortex Dictamni of 5 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
Preparation method is to get Radix Rehmanniae, Radix Paeoniae Alba, Radix Astragali, the wine Radix Salviae Miltiorrhizae, the salt Semen Astragali Complanati, Rhizoma drynariae preparata, stir-baked FRUCTUS TRIBULI, Radix Angelicae Sinensis (processed with wine), Rhizoma Chuanxiong, Herba Spirodelae, Radix Saposhnikoviae and Cortex Dictamni decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
3 parts of 5 parts of Rhizoma Chuanxiongs of 5 parts of salt Semen Astragali Complanatis of Radix Rehmanniae
3 parts in 5 portions of Herba Spirodelaes of 3 parts of Rhizoma drynariae preparatas of Radix Paeoniae Alba
2 parts of 3 parts of Radix Saposhnikoviaes of 5 parts of stir-baked FRUCTUS TRIBULIs of Radix Astragali
2 parts of 3 parts of Cortex Dictamni of 5 parts of Radix Angelicae Sinensis (processed with wine) of wine Radix Salviae Miltiorrhizae
Preparation method is to get Radix Rehmanniae, Radix Paeoniae Alba, Radix Astragali, the wine Radix Salviae Miltiorrhizae, the salt Semen Astragali Complanati, Rhizoma drynariae preparata, stir-baked FRUCTUS TRIBULI, Radix Angelicae Sinensis (processed with wine), Rhizoma Chuanxiong, Herba Spirodelae, Radix Saposhnikoviae and Cortex Dictamni decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, and the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, two months is a course of treatment.