CN100450531C - Chinese medicinal formulation for treating infant bed wetting - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating children's nocturnal enuresis, which is prepared from Chinese medicinal raw materials including ootheca rubra, polygala root, grassleaved sweetflag rhizome, morinda root, deglued antler powder, oyster shell, dodder seed, astragalus root and bitter cardamom.

Description

A kind of Chinese medicine preparation for the treatment of bed-wetting

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of bed-wetting, is that a kind of bed-wetting for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

The enuresis is meant the children's more than 5 years old, can not Autonomous Control urinate often sleeping back incontinence of urine.The cause of disease of wetting the bed, doctor trained in Western medicine viewpoint are thought and heredity and spiritual irriate; Congenital spina bifida, the foreskin phimosis, enterobiasiss etc. are relevant.Also have the enuresis of thinking and urinary system dissect or dysfunction relevant, as the bladder beard and hair educate unusually, bladder capacity minimizing or the rhythm and pace of moving things change etc. of urinating round the clock.Resemble according to sleep and experimental studies have found that the enuresis mainly is to occur in the non rapid eye movement sleep, NREMS phase (NREM), the electroencephalogram of this disease infant parahypnosis simultaneously is comparatively common.Having the scholar to think may be relevant with the nervus centralis delay of maturation.Most scholars think that the enuresis is that it is not normal to lack the training of hygienic habit and urinary function that other psychosocial factor cause because the raising mode is improper.The enuresis pilosity is born in 5～10 years old child, and boy is more to be seen.The clinical two big classes that generally are divided into: 1. primary enuresis: be meant after the birth bed-wetting person always; 2. secondary enuresis: refer to infant in 5 years old, does not wet the bed (about 3～6 months) once for some time, and the bed wetter is taken place thereafter again.The enuresis relevant with sleep disorder, the overwhelming majority are to belong to primary enuresis.But the spontaneous recovery usually of this disease increases the back enuresis with the age and disappears, and great majority just stopped later at 8 years old wetting the bed.

The traditional Chinese medical science is thought the generation and the congenital defect of this disease, following first deficiency and coldness, and asthenia of pulmonosplenic qi, scaring wait and cause.Its clinical manifestation is: 1, sleep is murky, is difficult to wake, do not know after waking up, and 2, easily perspire at ordinary times, night especially.3, the sleep posture mostly is and climbs or the curling oneself up formula.4, temper oddity, timid, introverted, winter or overcast and rainy increasing the weight of.The enuresis claims " incontinence of urine ", " bed-wetting ", " incontinence of urine " again.Be meant incontinence of urine in the sleep, a kind of disease that feel at the rear of waking up.The cause of disease has the following aspects: 1, because children's's physical weakness, and congenital deficiency of kidney-QI, deficiency-cold in the urinary bladder, gasification dereliction of duty, regulating fluid apssage, malfunction and the enuresis takes place.2, we think that deficiency of both the splenic and pulmonary QI, the spleen Tianjin of can not loosing returns lung, and the deficiency of the lung can not regulating fluid apssage, and bladder loses binding function, and the enuresis takes place.3, also have owing to thoughtless, with the passing of time form bad habit, and the enuresis takes place children's.4, in addition, also have because of suppressing the untimely drainage of urine, blocking up functioning of bladder, staying for a long time of urine given birth to damp and hot, and damp and hot visitor can cause the enuresis in bladder, and especially the child more more sees.

The traditional Chinese medical science thinks that the enuresis key is the YANG QI deficiency of kidney, or asthenia of pulmonosplenic qi, involves kidney, causes deficiency of kidney-QI, and the simple pulmonary deficiency of spleen-QI is more rare.So the astringent or styptic treatment for spontaneous sweating product of the kidney invigorating are selected in treatment for use,, execute flexibly and control with card feelings difference.The method of western medical treatment primary disease is a lot, but great majority can only reach recent clinical effectiveness, and can not prevent recurrence, and has toxic and side effects in various degree.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of bed-wetting, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.

The present invention is made by the following weight proportion raw material:

1.0～4.0 parts of 0.1～2.0 part of Rhizoma Acori Graminei of 1.5～6.0 parts of Radix Polygalae (processed) of Ootheca Mantidis

1.0～4.0 parts of 0.1～2.0 part of Concha Ostreae (calcined)s of 1.0～4.0 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

0.1～2.0 part of 1.5～6.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.5～6.0 parts of Radix Astragali of salt Semen Cuscutae

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 0.5～1.5 part of Rhizoma Acori Graminei of 2.5～3.5 parts of Radix Polygalae (processed) of Ootheca Mantidis

1.5～2.5 parts of 0.5～1.5 part of Concha Ostreae (calcined)s of 1.5～2.5 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

0.5～1.5 part of 2.5～3.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2.5～3.5 parts of Radix Astragali of salt Semen Cuscutae

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 1 part of Rhizoma Acori Graminei of 3 parts of Radix Polygalae (processed) of Ootheca Mantidis

2 parts of 1 part of Concha Ostreae (calcined)s of 2 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

1 part of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 3 parts of Radix Astragali of salt Semen Cuscutae

Drug action mechanism among the present invention is as follows:

The Ootheca Mantidis nature and flavor are sweet, salty, flat.Return liver, kidney channel.Effect with the kidney invigorating, controlling nocturnal emission with astringent drugs.Can treat seminal emission, nebulousurine, frequent micturition, the enuresis, leucorrhea with red and white discharge, sexual impotence, premature ejaculation etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1057th page).

Radix Polygalae (processed) nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.It is swollen etc. to treat phlegm retention, coma, cough, insomnia, palpitation with fear, forgetful, nocturnal emission, carbuncle skin ulcer.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 620th page).

Rhizoma Acori Graminei nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Have removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, ward off dirty parasite killing, blood pressure lowering, spasmolytic, anti-inflammation, the effect of detoxifying, regulate the flow of vital energy, invigorating blood circulation.Can treat epilepsy, expectorant febrile convulsion, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, anemofrigid-damp arthralgia, stomachache, distension and fullness in the abdomen, enteritis, dysentery, chronic bronchitis, infantile pneumonia, sputum obturation, obnubilation, carbuncle tinea scabies, traumatic injury etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 399th page).

Radix Morindae Officinalis (processed) nature and flavor suffering, sweet, tepor.Return liver, kidney channel.Effect with kidney-replenishing, strengthening bone and muscle, wind-damp dispelling.Can treat impotence and seminal emission, cold womb is infertile, menoxenia, and cold and pain in the lower abdomen, rheumatic arthralgia, the muscles and bones flaccidity is soft etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 350th page).

The Cornu Cervi Degelatinatum nature and flavor are salty, temperature.Return liver, kidney channel.Has tonify deficiency, supporing yang effect.Can treat insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses etc.(" Chinese medicine voluminous dictionary " the 2241st page).

The Concha Ostreae (calcined) nature and flavor are salty, be slightly cold.Return liver, gallbladder, kidney channel.Have tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Can be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula productive cough, lump in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 674th page).

Salt Semen Cuscutae nature and flavor suffering, sweet, warm, flat.Return the liver,kidney,spleen warp.Have invigorating the liver and kidney, beneficial marrow, the smart effect of the benefit that makes eye bright.Can treat soreness of waist and knee joint, impotence and seminal emission, quench one's thirst, dripping urination, order are dark, have a dizzy spell, visual deterioration, frequent fetal movement, frequent micturition etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 956th page).

The Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.That can treat that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).

Stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution nature and flavor suffering, temperature.Return spleen, kidney channel.Have warming spleen and stopping diarrha, the effect of warming the kidney controlling nocturnal emission with astringent drugs reducing urination.Can treat that spleen-cold syndrome is had loose bowels, cold type of pain in the abdomen, mouthful slaver over more, enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1048th page).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Ootheca Mantidis, Cornu Cervi Degelatinatum, Radix Morindae Officinalis (processed) and stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, is ministerial drug with Radix Astragali, salt Semen Cuscutae and Concha Ostreae (calcined), is adjuvant with Radix Polygalae (processed) and Rhizoma Acori Graminei.All medicine phases and the effect that is total to tool warming and recuperating the kidney-YANG, controlling nocturnal emission with astringent drugs reducing urination, tranquillizing and allaying excitement, the treatment bed-wetting has determined curative effect, has no side effect taking convenience, cheap characteristics.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment bed-wetting of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.

Bed-wetting curative effect determinate standard (the 533rd page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).

1, cures: the enuresis more not after controlling.

2, take a turn for the better: enuresis number of times reduces more than 1/2, can wake in the sleep and urinate.

3, do not heal: enuresis no change or slight variation is only arranged.

Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment bed-wetting.

As follows through clinical test results; Treatment bed-wetting patient 32 examples, male's 20 examples, women's 12 examples, the age is 3～15 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 26 examples and account for 81.25%, 6 examples that take a turn for the better account for 9.37%, and total effective rate reaches 100%.After three course of therapy, symptoms such as patient's enuresis etc. all have clear improvement or fully recover.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment 1 capsule takes by weighing raw material by following weight:

2 parts of 1 part of Rhizoma Acori Graminei of 3 parts of Radix Polygalae (processed) of Ootheca Mantidis

2 parts of 1 part of Concha Ostreae (calcined)s of 2 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

1 part of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 3 parts of Radix Astragali of salt Semen Cuscutae

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 2 tablets take by weighing raw material by following weight:

2 parts of 1 part of Rhizoma Acori Graminei of 3 parts of Radix Polygalae (processed) of Ootheca Mantidis

2 parts of 1 part of Concha Ostreae (calcined)s of 2 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

1 part of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 3 parts of Radix Astragali of salt Semen Cuscutae

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 3 granules take by weighing raw material by following weight:

2 parts of 1 part of Rhizoma Acori Graminei of 3 parts of Radix Polygalae (processed) of Ootheca Mantidis

2 parts of 1 part of Concha Ostreae (calcined)s of 2 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

1 part of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 3 parts of Radix Astragali of salt Semen Cuscutae

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～5 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of bed-wetting is characterized in that it is made by following raw materials by weight proportions:

1.0～4.0 parts of 0.1～2.0 part of Rhizoma Acori Graminei of 1.5～6.0 parts of Radix Polygalae (processed) of Ootheca Mantidis

1.0～4.0 parts of 0.1～2.0 part of Concha Ostreae (calcined)s of 1.0～4.0 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

0.1～2.0 part of 1.5～6.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1.5～6.0 parts of Radix Astragali of salt Semen Cuscutae.

2, a kind of Chinese medicine preparation for the treatment of bed-wetting according to claim 1, wherein the weight proportion of each crude drug is:

1.5～2.5 parts of 0.5～1.5 part of Rhizoma Acori Graminei of 2.5～3.5 parts of Radix Polygalae (processed) of Ootheca Mantidis

1.5～2.5 parts of 0.5～1.5 part of Concha Ostreae (calcined)s of 1.5～2.5 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

0.5～1.5 part of 2.5～3.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 2.5～3.5 parts of Radix Astragali of salt Semen Cuscutae.

3, a kind of Chinese medicine preparation for the treatment of bed-wetting according to claim 1, wherein the weight proportion of each crude drug is:

2 parts of 1 part of Rhizoma Acori Graminei of 3 parts of Radix Polygalae (processed) of Ootheca Mantidis

2 parts of 1 part of Concha Ostreae (calcined)s of 2 parts of Cornu Cervi Degelatinatums of Radix Morindae Officinalis (processed)

1 part of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 3 parts of Radix Astragali of salt Semen Cuscutae.