CN100450532C - Chinese medicinal formulation for treating children's hyperkinetic syndrome - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating children's hyperkinetic symptom, which is prepared from Chinese medicinal herbs including deglued antler powder, prepared rehmannia root, bitter cardamon, wild jujuba seeds, mother-of-pearl, grassleaved sweetflag rhizome, polygala root, plantago asiatica linne and gentian root.

Description

A kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome, is that a kind of hyperkinetic syndrome for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Hyperkinetic syndrome is a kind of common children's behavior abnormal problem, claims Cerebral function slight maladjustment or slight dysfunction syndrome or attention deficit hyperactivity disorder again.This class infant intelligence normally or normal substantially, but study, behavior and emotion aspect defectiveness show as difficult concentrating, note of short duration, hyperactivity, emotion is inflammable so that influence school grade.All keep on unpleasant terms with people in family and school, make the head of a family and teacher feel difficulty in the daily life.The foreign data report is ill to be about 5%～10%.Domestic to think that also school age population is sent out the patient quite a lot of, accounts for all pupils 1%～10%.Boy is many than girl, and about 4～9: 1.Send out 6～14 years old age well.Not only influence child's physical and mental health, develop into aggressivity, destructive behavior sometimes.Become the problem of social concerns in recent years.

Chinese medicine thinks that the natural endowment deficiency is the endogenous cause of ill of primary disease, and is in bad health as father and mother, particularly mother's pregnancy period how sick, cause the plain body weakness of children.Lack of proper care after one's birth, maternal infuries or other sick wounds, and educate the improper morbidity that all can cause.The clinical symptoms of hyperkinetic syndrome is: 1, attention deficit disorder: show as absent mindedly, not lasting, disperse easily; It is inwholwe-hearted to listen to the teacher, and can not fulfil assignment on time, is divert one's attention by environmental stimuli easily.2, hyperactivity: show as on the classroom or the quiet heart that do not descend during operation, do not stop twisting on seat, or the class hour of lasting did little trick, desk was cut rubber, or was gazed around fingernail biting, quarter, influenced the classroom order; Just run around here and there after class, brothers do not stop or disorderly dash disorderly and hit.3, impulsion is wilful: show as disposition and suddenly make an uproar, hot-tempered, it is disorderly and unsystematic to do things, and impulsion property, aggression are arranged, and as can not patience waiting, disturbs other people activity; Handling affairs lacks thinking, is regardless of the consequences, even destroys thing, fights, and provokes a dispute.4, behavior change: show as slow movement, operation can not be finished for a long time; Emotion fluctuates easily, being happy and angry uncertainly.5, learning difficulty is the result of hyperkinetic syndrome.To compare following symptom more common with Most of children of the same age, need possess eight in the following behavior.1, usually hands or foot-propelled are individual does not stop or does not stop on seat to twist.Be difficult to sit quietly when 2, wanting it to sit quietly.3, be subjected to environmental stimuli easily and take sb's mind off sth.4, can not wait in line wheel patiently in recreation or collective activity substitutes in.5, usually not intact promptly the robbing of others' question answered.6, be difficult to do thing by others' indication.7, in operation or recreation, be difficult to keep attention to be concentrated.8, usually another part thing is not finished and changed to something.9, be difficult to undisturbedly play.10, often words are many.11, often interrupt or disturb the activity that upsets others, as disturb other children's game.12, others and he when speaking usually like listening non-tin.13, usually be lost in study and the movable article that will use in school or the family.14, usually participate in the adventurous activity of body do not considered the consequence that may cause.Belong to categories such as " restless ", " becoming deaf ", " forgetful " according to clinical manifestation.

The traditional Chinese medical science is divided into disease type determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs such as the liver of suffering from a deficiency of the kidney is high, deficiency of both the heart and spleen, type of phlegm-heat attacking the heart and has received effect preferably.The method of western medical treatment primary disease is a lot, but great majority can only reach recent clinical effectiveness, and can not prevent recurrence, and has toxic and side effects in various degree.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.

The present invention is made by the following weight proportion raw material:

0.5～3.0 part of 1.5～6.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 0.1～2.0 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

1.5～6.0 parts of 0.5～3.0 part of living Concha Margaritiferas of 0.5～3.0 part of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

0.1～2.0 part of 0.1～2.0 part of wine Radix Gentianae of 0.1～2.0 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

The weight proportion of each raw material of optimization formula of the present invention is:

1.0～2.0 parts of 2.5～3.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 0.5～1.5 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

2.5～3.5 parts of 1.0～2.0 parts of living Concha Margaritiferas of 1.0～2.0 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

0.5～1.5 part of 0.5～1.5 part of wine Radix Gentianae of 0.5～1.5 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

The weight proportion of each raw material of optimum formula of the present invention is:

1.5 parts of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

3 parts of 1.5 parts of living Concha Margaritiferas of 1.5 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

1 part of 1 part of wine Radix Gentianae of 1 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

Drug action mechanism among the present invention is as follows:

The Cornu Cervi Degelatinatum nature and flavor are salty, temperature.Return liver, kidney channel.Has tonify deficiency, supporing yang effect.Can treat insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses etc.(" Chinese medicine voluminous dictionary " the 2241st page).

The Radix Rehmanniae Preparata nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

Stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution nature and flavor suffering, temperature.Return spleen, kidney channel.Have warming spleen and stopping diarrhaly, the warming the kidney controlling nocturnal emission with astringent drugs is compiled the effect of urine.Can treat that spleen-cold syndrome is had loose bowels, cold type of pain in the abdomen, mouthful slaver over more, enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1048th page).

The Semen Ziziphi Spinosae (parched) nature and flavor are sweet, flat.GUIXIN, spleen, liver, gallbladder meridian.Have nourishing the liver, mind calming is calmed the nerves, the effect of arresting sweating.Can treat restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility etc.(" Chinese medicine voluminous dictionary " the 2535th page).

It is salty, cold to give birth to the Concha Margaritifera nature and flavor.Return liver, heart channel.Has suppressing the hyperactive liver and subsiding YANG, the effect that arresting convulsion makes eye bright.Can treat that dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, haematemesis, epistaxis, metrorrhagia, liver-heat conjunctival congestion, deficiency of the liver blurred vision, irritability, deficiency of the liver are timid, hyperchlorhydria, anovulatory dysfunctional uterine hemorrhage, hemorrhage due to artificial abortion etc.(Ji Zibin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 854th page).

Rhizoma Acori Graminei nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Have removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, ward off dirty parasite killing, blood pressure lowering, spasmolytic, anti-inflammation, the effect of detoxifying, regulate the flow of vital energy, invigorating blood circulation.Can treat epilepsy, expectorant febrile convulsion, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, anemofrigid-damp arthralgia, stomachache, distension and fullness in the abdomen, enteritis, dysentery, chronic bronchitis, infantile pneumonia, sputum obturation, obnubilation, carbuncle tinea scabies, traumatic injury etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 399th page).

Radix Polygalae (processed) nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.It is swollen etc. to treat phlegm retention, coma, cough, insomnia, palpitation with fear, forgetful, nocturnal emission, carbuncle skin ulcer.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 620th page).

The stir-baked SEMEN PLANTAGINIS with salt solution nature and flavor are sweet, be slightly cold.Return liver, kidney, lung, small intestinal, urinary bladder channel.Has clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, the effect of removing heat from the lung and dissipating phlegm.Can treat the cough due to lung-heat, urinary system infection, calculus, gastritis edema, dysuria, enteritis, bacillary dysentery, acute icterohepatitisshock, bronchitis, acute eye conjunctivitis, stranguria with turbid discharge, leukorrhagia, hematuria, edema, hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis, cough, skin ulcer etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 291st page).

Wine Radix Gentianae nature and flavor hardship, cold.Return liver, gallbladder meridian.Have eliminating pathogen in the liver gallbladder fire, the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is wet, relieving convulsion making eye bright, and the malaria protozoon is good for the stomach, the effect that protects the liver.Can treat that Liver Channel intenseness of heat, infantile convulsion are manic, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the swollen skin infection of pain, scrotum swell and ache, pudendum pruritus due to damp pathogen, hypertension dizziness tinnitus, chest and hypochondrium, acute infectious hepatitis, cystitis, skin infection swell and ache etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 413rd page).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Cornu Cervi Degelatinatum, Radix Rehmanniae Preparata, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution and Semen Ziziphi Spinosae (parched), is ministerial drug with giving birth to Concha Margaritifera and Rhizoma Acori Graminei, is adjuvant with Radix Polygalae (processed), stir-baked SEMEN PLANTAGINIS with salt solution and wine Radix Gentianae.All medicine phases and the effect that is total to tool temperature compensation Liver and kidney, YIN nourishing and the production of body fluid promoting, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, the treatment hyperkinetic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention hyperkinetic syndrome of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.

3, the present invention not only can effectively treat hyperkinetic syndrome, and the prevention of hyperkinetic syndrome is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.

Hyperkinetic syndrome curative effect determinate standard ((the 353rd page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen)

1, cure: the class hour of lasting attention concentrated, emotion is more stable, school grade reaches the level with the age child substantially.2, take a turn for the better: action reduces, and the time of sitting quietly is longer, and attention is concentrated slightly, and school grade rises to some extent.3, do not heal: symptom and school grade do not have significant change.

Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment hyperkinetic syndrome.

As follows through clinical test results; Treatment hyperkinetic syndrome patient 39 examples, male's 28 examples, women's 11 examples, the age is 6～14 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 23 examples and account for 58.9%, 12 examples that take a turn for the better account for 30.7%, and more 4 examples do not account for 10.25%, and total effective rate reaches 89.75%.After three course of therapy, patient's attention of last class hour is concentrated, and emotion is more stable, and school grade rises to some extent.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment 1 capsule takes by weighing raw material by following weight:

1.5 parts of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

3 parts of 1.5 parts of living Concha Margaritiferas of 1.5 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

1 part of 1 part of wine Radix Gentianae of 1 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 2 tablets take by weighing raw material by following weight:

1.5 parts of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

3 parts of 1.5 parts of living Concha Margaritiferas of 1.5 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

1 part of 1 part of wine Radix Gentianae of 1 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.

Embodiment 3 granules take by weighing raw material by following weight:

1.5 parts of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

3 parts of 1.5 parts of living Concha Margaritiferas of 1.5 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

1 part of 1 part of wine Radix Gentianae of 1 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed)

Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome is characterized in that it is made by following raw materials by weight proportions:

0.5～3.0 part of 1.5～6.0 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 0.1～2.0 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

1.5～6.0 parts of 0.5～3.0 part of living Concha Margaritiferas of 0.5～3.0 part of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

0.1～2.0 part of 0.1～2.0 part of wine Radix Gentianae of 0.1～2.0 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed).

2, a kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome according to claim 1, wherein the weight proportion of each crude drug is:

1.0～2.0 parts of 2.5～3.5 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 0.5～1.5 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

2.5～3.5 parts of 1.0～2.0 parts of living Concha Margaritiferas of 1.0～2.0 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

0.5～1.5 part of 0.5～1.5 part of wine Radix Gentianae of 0.5～1.5 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed).

3, a kind of Chinese medicine preparation for the treatment of hyperkinetic syndrome according to claim 1, wherein the weight proportion of each crude drug is:

1.5 parts of 3 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution of 1 part of Radix Rehmanniae Preparata of Cornu Cervi Degelatinatum

3 parts of 1.5 parts of living Concha Margaritiferas of 1.5 parts of Rhizoma Acori Graminei of Semen Ziziphi Spinosae (parched)

1 part of 1 part of wine Radix Gentianae of 1 part of stir-baked SEMEN PLANTAGINIS with salt solution of Radix Polygalae (processed).