CN102205032B - Golden mushroom oral liquid for treating hyperactivity disease - Google Patents

Abstract

The invention relates to golden mushroom oral liquid for treating hyperactivity disease in the technical field of medicinal health care. The golden mushroom oral liquid comprises the following components in part by weight: 80 to 100 parts of golden mushroom amino acid dry powder, 130 to 150 parts of grassleaf sweelflag rhizome, 90 to 110 parts of Chinese magnoliavine fruit, 50 to 60 parts of root of red-rooted salvia, 30 to 40 parts of raw dragon's bone, 15 to 18 parts of prepared rehmannia root, 8 to 10 parts of Indian buead, 8 to 10 parts of white paeony root, 70 to 80 parts of cinnamomvine, 80 to 90 parts of heartleaf houttuynia herb and 50 to 60 parts of mongolian dandelion herb. The golden mushroom oral liquid is prepared by the following steps of: weighing the grassleaf sweelflag rhizome, the Chinese magnoliavine fruit, the root of red-rooted salvia, the raw dragon's bone, the prepared rehmannia root, the Indian buead, the white paeony root, the cinnamomvine, the heartleaf houttuynia herb and the mongolian dandelion herb according to a formula; decocting for 2 to 3 hours; filtering, and concentrating; and adding the golden mushroom amino acid dry powder. The golden mushroom oral liquid fully exerts the mentality promotion effect of golden mushroom, is compatible with medicaments for soothing nerves and inducing diuresis, can be used for treating the hyperactivity disease effectively, and has quick response and a good treatment effect, so children of motherland can grow healthily and smoothly, and the vexation of parents is solved.

Description

A kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome

Technical field

The present invention relates to the medicines and health protection technical field, particularly a kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome.

Background technology

Childhood hyperkinetic syndrome is claimed hyperkinetic syndrome (ADHD) or minimal brain dysfunciton syndrome again, is that a kind of common child is abnormal diseases.The intelligence of this type infant normally or normal basically, but study, behavior and emotion aspect defectiveness mainly show as absent minded; Note of short duration; Hyperactivity, emotion is inflammable, and school grade is generally relatively poor; All keep on unpleasant terms with people in family and school, usually make the head of a family and teacher feel to have no idea in the daily life.

The prevalence of childhood hyperkinetic syndrome abroad is reported between 5% ~ 10%, and domestic investigation is more than 10%, and boy is more than girl, and premature infant and cut open the palace newborn baby to suffer from the probability of hyperkinetic syndrome higher is greatly about more than 60%.

Think now many moving and absent minded maybe be relevant with catecholamine system in the brain (norepinephrine etc., its predecessor is a dopamine) insufficiency of function.Medicament reduces the storage of dopamine in the rat brain or when exhausting, hyperkinesia disease appears in animal in the zoopery.The DOPA land reclamation and cultivation improves the activity of dopamine neuron at the content at synapse position in the brain to improve to take amfetamine to animal, can make animal quiet.

There is the Chinese medicine composition of a lot of treatment childhood hyperkinetic syndromes all to be authorized patent right, also has a variety of preparations to be used clinically.

Commercially available have kind of a TAIYANGSHEN Flammulina velutipes oral liquid, and effect is immunomodulating, improve one's physical development, improve memory.Mainly contain trace element such as biological strong stock solution, JINZHENGU, Fructus Crataegi, Fructus Jujubae, taurine, zinc; Though contain JINZHENGU; But wherein taurine is a kind of inhibitory transmitter of central nervous system; To nervous system abnormality irritability disease (like hyperkinetic syndrome), good role of correcting is arranged, so mention JINZHENGU hyperkinetic syndrome there is not good therapeutical effect.Use JINZHENGU to prepare treatment childhood hyperkinetic syndrome medicine and be still a blank so far.

Nutritional labelings such as JINZHENGU rich in proteins, aminoacid and carbohydrate, because of being rich in arginine, lysine and several mineral materials and vitamin, growth plays an important role to children's intelligence, is called as " Fructus Alpiniae Oxyphyllae mushroom " in Japan.

Summary of the invention

In order to fill up the blank of above use JINZHENGU treatment childhood hyperkinetic syndrome technology, what the invention provides a kind of effective, treatment childhood hyperkinetic syndrome that cost is low is the oral liquid of host with the JINZHENGU.

The present invention realizes through following measure:

A kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome, used raw material comprises the component of following weight portion:

JINZHENGU aminoacid dry powder 80-100 part, Rhizoma Acori Graminei 130-150 part, Fructus Schisandrae Chinensis 90-110 part, Radix Salviae Miltiorrhizae 50-60 part, Os Draconis 30-40 part, Radix Rehmanniae Preparata 15-18 part, Poria 8-10 part, Radix Paeoniae Alba 8-10 part, Rhizoma Dioscoreae 70-80 part, Herba Houttuyniae 80-90 part, Herba Taraxaci 50-60 part;

Said JINZHENGU oral liquid obtains through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio, add the boiled water of 5-8 times of weight, boiled 2-3 hour; Cross and filter filtrating, being concentrated into relative density is 1.2, adds JINZHENGU aminoacid dry powder; Stir, packing promptly gets.

Also comprise 7 portions of white sugars, 0.4 part of citric acid, 0.2 part of vitamin C and 10 parts of natural honeys.

Said JINZHENGU aminoacid dry powder is made by following steps:

(1) the JINZHENGU dry powder after the defat is added in the hydrochloric acid of 6mol/L by weight 1:10, get hydrolyzed solution at 110 ℃ of backflow 24h;

(2) hydrolyzed solution is removed HCI through concentrating under reduced pressure, adds the distilled water of 3 times of weight and the activated carbon of 2wt%, under 90 ℃ of conditions, stirs decolouring 1h, and sucking filtration obtains the hydrolyzed solution that decolours;

(3) will decolour that to regulate pH be 1-2 to the hydrolyzed solution thin up, use strongly acidic cation-exchange post eluting, resin column internal diameter 100mm; The resin loading height is 8cm, and equilibrium velocity is 24mL/h, and use pH is 5.4 citrate buffer solution eluting; The sample of adding is 1:20 with buffer volume ratio, begins to collect effluent from the variable color of 1,2,3-indantrione monohydrate developer, arrives no longer variable color end collection effluent of 1,2,3-indantrione monohydrate developer; The effluent of collecting both had been an eluent, and eluent promptly gets the JINZHENGU coarse amino acid through concentrating post crystallization; The water dissolution that adds 10 times of weight, with the 95wt% washing with alcohol of 15 times of weight, the gained solid promptly gets JINZHENGU aminoacid dry powder through spray drying.

Rhizoma Acori Graminei: the refreshment of having one's ideas straightened out, removing dampness, eliminating phlegm;

Fructus Schisandrae Chinensis: can activate nervous system, promote respond, concentrate power and coordinative role, and it is clear to strengthen thinking, although it has activated effect, does not have caffeine side effect restless;

Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind;

Os Draconis: astringing QI ends night sweat by wet, calms the nerves;

Radix Rehmanniae Preparata: it is moist to enrich blood; The benefit essence is filled out marrow;

Poria: diuretic, eliminating dampness by diuresis diuresis;

The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant;

Rhizoma Dioscoreae: enriching spleen-QI and stomach reinforcing is cloudy;

Herba Houttuyniae: heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome;

Herba Taraxaci: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.

Beneficial effect of the present invention: give full play to the JINZHENGU nootropic effect, and calm the nerves and the diuretic compatibility, can effectively treat childhood hyperkinetic syndrome, rapid-action, therapeutic effect good, make the flowers of motherland can be healthy, grow up smoothly, solved the head of a familys' worry.

The specific embodiment

For a better understanding of the present invention, further specify below in conjunction with specific embodiment.

The making of JINZHENGU aminoacid dry powder:

(1) the JINZHENGU dry powder after the defat is added in the hydrochloric acid of 6mol/L by weight 1:10, under 110 ℃ of conditions of oil bath, normal pressure reflux 24h obtains hydrolyzed solution,

(2) hydrolyzed solution is removed HCI through concentrating under reduced pressure, adds the distilled water of 3 times of weight and the activated carbon of 2wt%, under 90 ℃ of conditions, stirs decolouring 1h, and sucking filtration obtains the hydrolyzed solution that decolours while hot,

(3) with above-mentioned decolouring hydrolyzed solution, it is 1-2 that thin up is regulated pH, last strongly acidic cation-exchange post eluting, and resin column internal diameter 100mm, the resin loading height is 8cm, and the buffer that uses is 5.4 citrate buffer solution as pH, and the concrete operations step is following:

1. the buffer bottle is linked to each other with constant flow pump, the constant flow pump outlet links to each other with the chromatographic column inlet, and resin surface keeps the 3-4cm liquid layer, starts weighing apparatus stream pump, and is with 24ml/h flow velocity balance, identical with buffer until effluent pH;

2. throw off chromatographic column lid suitable for reading, treat in the post that liquid level closes outlet to resin surface 1-2mm, the careful sample that adds around the tube wall is slowly opened outlet, begins to collect effluent simultaneously, connects constant flow pump and uses buffer solution elution;

3. begin to collect effluent from the variable color of 1,2,3-indantrione monohydrate developer, arrive no longer variable color end collection effluent of 1,2,3-indantrione monohydrate developer, the sample of adding is 1:20 with buffer volume ratio; The effluent of collecting both had been an eluent; Eluent promptly gets the JINZHENGU coarse amino acid through concentrating post crystallization, adds the water dissolution of 10 times of weight; With the 95wt% washing with alcohol of 15 times of weight, the gained solid promptly gets JINZHENGU aminoacid dry powder through spray drying.

Embodiment 1:

A kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome comprises that the component of following weight portion is processed:

80 parts in JINZHENGU aminoacid dry powder, 130 parts of Rhizoma Acori Graminei, 90 parts of Fructus Schisandrae Chinensis, 50 parts of Radix Salviae Miltiorrhizaes, 30 parts of Os Draconis, 15 parts of Radix Rehmanniae Preparata, 8 parts in Poria, 8 parts of the Radix Paeoniae Albas, 70 parts of Rhizoma Dioscoreaes, 80 parts of Herba Houttuyniae, 50 parts of Herba Taraxacis;

Make through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio; The boiled water that adds 5 times of weight boiled 2 hours, crossed to filter filtrating; Being concentrated into relative density is 1.2; Add JINZHENGU aminoacid dry powder, stir, the bottle that is distributed into 15mL promptly gets.

Embodiment 2:

A kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome is characterized in that the component that comprises following weight portion processes:

100 parts in JINZHENGU aminoacid dry powder, 150 parts of Rhizoma Acori Graminei, 110 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Salviae Miltiorrhizaes, 40 parts of Os Draconis, 18 parts of Radix Rehmanniae Preparata, 10 parts in Poria, 10 parts of the Radix Paeoniae Albas, 80 parts of Rhizoma Dioscoreaes, 90 parts of Herba Houttuyniae, 60 parts of Herba Taraxacis;

Said JINZHENGU oral liquid obtains through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio, add the boiled water of 8 times of weight, boiled 3 hours; Cross and filter filtrating, being concentrated into relative density is 1.2, adds JINZHENGU aminoacid dry powder; Stir, packing promptly gets.

Embodiment 3:

A kind of JINZHENGU oral liquid of treating childhood hyperkinetic syndrome, process by the component of following weight portion:

90 parts in JINZHENGU aminoacid dry powder, 120 parts of Rhizoma Acori Graminei, 100 parts of Fructus Schisandrae Chinensis, 55 parts of Radix Salviae Miltiorrhizaes, 35 parts of Os Draconis; 16 parts of Radix Rehmanniae Preparata, 9 parts in Poria, 9 parts of the Radix Paeoniae Albas, 75 parts of Rhizoma Dioscoreaes, 85 parts of Herba Houttuyniae; 55 parts of Herba Taraxacis, 7 parts of white sugars, 0.4 part of citric acid, 10 parts of 0.2 part of vitamin C and natural honeys.

Said JINZHENGU oral liquid obtains through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio; The boiled water that adds 5-8 times of weight boiled 2-3 hour, crossed to filter filtrating; Being concentrated into relative density is 1.2; Add JINZHENGU aminoacid dry powder, white sugar, citric acid, vitamin C and natural honey, stir, the bottle that is distributed into 15mL promptly gets.

The clinical treatment test

1, clinical data

150 patients that have been accredited as childhood hyperkinetic syndrome with Jinan children's hospital are treatment target, and wherein boy is 80,70 of girls, and 7.3 years old mean age, medical history is 0.5-2.

2, Therapeutic Method

150 patients are taken all factors into consideration factors such as sex, medical history, age be divided into two groups, A group and B group, every group of 75 patients.

A group patient takes JINZHENGU oral liquid of the present invention, sooner or later each once, each 20mL, take two 40 days courses of treatment continuously after, the test therapeutic outcome; B group patient takes commercially available a kind of Chinese medicine composition of treating childhood hyperkinetic syndrome, takes according to taking explanation, take two 40 days courses of treatment continuously after, the test therapeutic outcome.

3, criterion of therapeutical effect

Produce effects: cardinal symptom disappears or significantly improves, and how moving index scoring reduces more than 80%;

Effectively: cardinal symptom is improved, and how moving index scoring reduces more than 50%;

Invalid: no change after the medication.

4, therapeutic outcome

Through the treatment of 40 days two courses of treatment, therapeutic outcome sees the following form 1.

Table 1 therapeutic effect contrast table

Effective percentage=(produce effects quantity+effective quantity)/patient's total quantity * 100%

Model case:

1, Zhao so-and-so, the man, 10 years old, naughty, obviously absent minded, little trick is many, running chaotically dapped, study does not catch up with, and does something by halves, operation, textbook, stationery are always forgetful, final examination is failed.Take course of treatment of oral liquid of the present invention, teacher reacts class hour, and he is obviously honest a lot, on the seat, also can sit still, and the time that attention is concentrated also begins slowly elongated.Through the treatment of three courses of treatment, friend neighbours say that he is steady much, no longer forgetful, running chaotically daps, and all there is the raising more than 10 minutes in the average every section of school grade.

2, grandson so-and-so, the woman, 13 years old, irritated impulsion, hot-tempered, wilfulness, emotional instability is difficult to attentively listen to the teacher; Operation can not be accomplished on time.Through expert inspection, so-and-so is indigestion and loss of appetite for grandson, bitter taste, and thirsty polydipsia, dry stool is become thin, weak, lusterless complexion, abundant expectoration uncomfortable in chest, slippery and rapid pulse, dark coloured urine, yellow and greasy fur.The tcm diagnosis result: restless (type of phlegm-heat attacking the heart) companion dysfunction of spleen and stomach, hepatic and renal function goes down; Western medicine diagnose result: hyperkinetic syndrome, Liver and kidney impaired (toxin delay).Take course of treatment of oral liquid of the present invention, the symptom on the health be improved significantly, and begin to become patient; No longer jump on someone, fulfil assignment on time, take three courses of treatment after; Symptom is greatly improved, and all there is the raising more than 13 minutes in the average every section of school grade.

3, Lee so-and-so, the man, 7 years old, it was rapid unstable to walk at ordinary times; Constantly do little trick as stinging pencil, pullling the classmate on class, look smug or conceited, all keep on unpleasant terms with people in family and school; Operation to teacher arranges is dragged one's heels always and can not be accomplished on time, even can not undisturbedly watch interested recreation or TV programme, begins to think that child is active; But sports performance is very poor always, and acrobatic gymnastics seems, and comparison is clumsy, and school grade descends always.Take oral liquid of the present invention after one course of treatment, can undisturbedly sit down basically see TV with done the homework, take three courses of treatment after; Symptom is obviously improved, and school grade also improves a lot, and the end of term is cited as " best progressive prize "; Get a diploma, greatly inspired child.

Claims (2)

1. JINZHENGU oral liquid of treating childhood hyperkinetic syndrome is characterized in that raw-material weight part is following:

JINZHENGU aminoacid dry powder 80-100 part, Rhizoma Acori Graminei 130-150 part, Fructus Schisandrae Chinensis 90-110 part, Radix Salviae Miltiorrhizae 50-60 part, Os Draconis 30-40 part, Radix Rehmanniae Preparata 15-18 part, Poria 8-10 part, Radix Paeoniae Alba 8-10 part, Rhizoma Dioscoreae 70-80 part, Herba Houttuyniae 80-90 part, Herba Taraxaci 50-60 part;

Said JINZHENGU oral liquid obtains through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio, add the boiled water of 5-8 times of weight, boiled 2-3 hour; Cross and filter filtrating, being concentrated into relative density is 1.2, adds JINZHENGU aminoacid dry powder; Stir, packing promptly gets;

Said JINZHENGU aminoacid dry powder is made by following steps:

(1) the JINZHENGU dry powder after the defat is added in the hydrochloric acid of 6mol/L by weight 1:10, get hydrolyzed solution at 110 ℃ of backflow 24h;

(2) hydrolyzed solution is removed HCI through concentrating under reduced pressure, adds the distilled water of 3 times of weight and the activated carbon of 2wt%, under 90 ℃ of conditions, stirs decolouring 1h, and sucking filtration obtains the hydrolyzed solution that decolours;

(3) will decolour that to regulate pH be 1-2 to the hydrolyzed solution thin up, use strongly acidic cation-exchange post eluting, resin column internal diameter 100mm; The resin loading height is 8cm, and equilibrium velocity is 24mL/h, and use pH is 5.4 citrate buffer solution eluting; The sample of adding is 1:20 with buffer volume ratio, begins to collect effluent from the variable color of 1,2,3-indantrione monohydrate developer, arrives no longer variable color end collection effluent of 1,2,3-indantrione monohydrate developer; The effluent of collecting both had been an eluent, and eluent promptly gets the JINZHENGU coarse amino acid through concentrating post crystallization; The water dissolution that adds 10 times of weight, with the 95wt% washing with alcohol of 15 times of weight, the gained solid promptly gets JINZHENGU aminoacid dry powder through spray drying.

2. JINZHENGU oral liquid of treating childhood hyperkinetic syndrome is characterized in that raw-material weight part is following:

90 parts in JINZHENGU aminoacid dry powder, 120 parts of Rhizoma Acori Graminei, 100 parts of Fructus Schisandrae Chinensis, 55 parts of Radix Salviae Miltiorrhizaes, 35 parts of Os Draconis; 16 parts of Radix Rehmanniae Preparata, 9 parts in Poria, 9 parts of the Radix Paeoniae Albas, 75 parts of Rhizoma Dioscoreaes, 85 parts of Herba Houttuyniae; 55 parts of Herba Taraxacis, 7 parts of white sugars, 0.4 part of citric acid, 10 parts of 0.2 part of vitamin C and natural honeys;

Said JINZHENGU oral liquid obtains through following steps:

Take by weighing Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Os Draconis, Radix Rehmanniae Preparata, Poria, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Herba Houttuyniae, Herba Taraxaci by formula ratio; The boiled water that adds 5-8 times of weight boiled 2-3 hour, crossed to filter filtrating; Being concentrated into relative density is 1.2; Add JINZHENGU aminoacid dry powder, white sugar, citric acid, vitamin C and natural honey, stir, the bottle that is distributed into 15mL promptly gets;

Said JINZHENGU aminoacid dry powder is made by following steps:

(1) the JINZHENGU dry powder after the defat is added in the hydrochloric acid of 6mol/L by weight 1:10, get hydrolyzed solution at 110 ℃ of backflow 24h;

(2) hydrolyzed solution is removed HCI through concentrating under reduced pressure, adds the distilled water of 3 times of weight and the activated carbon of 2wt%, under 90 ℃ of conditions, stirs decolouring 1h, and sucking filtration obtains the hydrolyzed solution that decolours;

(3) will decolour that to regulate pH be 1-2 to the hydrolyzed solution thin up, use strongly acidic cation-exchange post eluting, resin column internal diameter 100mm; The resin loading height is 8cm, and equilibrium velocity is 24mL/h, and use pH is 5.4 citrate buffer solution eluting; The sample of adding is 1:20 with buffer volume ratio, begins to collect effluent from the variable color of 1,2,3-indantrione monohydrate developer, arrives no longer variable color end collection effluent of 1,2,3-indantrione monohydrate developer; The effluent of collecting both had been an eluent, and eluent promptly gets the JINZHENGU coarse amino acid through concentrating post crystallization; The water dissolution that adds 10 times of weight, with the 95wt% washing with alcohol of 15 times of weight, the gained solid promptly gets JINZHENGU aminoacid dry powder through spray drying.