CN111346172B - Pharmaceutical composition for improving immunity - Google Patents
Pharmaceutical composition for improving immunity Download PDFInfo
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- CN111346172B CN111346172B CN202010395653.XA CN202010395653A CN111346172B CN 111346172 B CN111346172 B CN 111346172B CN 202010395653 A CN202010395653 A CN 202010395653A CN 111346172 B CN111346172 B CN 111346172B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a pharmaceutical composition for improving immunity, which is prepared from 1-2 parts of pseudo-ginseng, 4-8 parts of polygonatum odoratum, 4-8 parts of lily, 4-8 parts of bighead atractylodes rhizome and 4-8 parts of wolfberry fruit. The composition can be prepared into various common oral preparations, and the preparations can obviously improve the immunity.
Description
Technical Field
The present invention relates to medical formulations, and in particular to pharmaceutical formulations of undefined structure of traditional herbal medicine.
Background
In recent years, the great amount of exhaust gas discharged by modern industry causes the damage of the earth atmosphere, global warming and greenhouse effect; the excessive discharge of harmful substances causes pollution to air, soil and water sources; various metabolic disorders caused by overnutrition, obstructed toxin excretion in vivo and cardiovascular and cerebrovascular diseases induced; the indoor environment with temperature control in four seasons enables mites, aphids, spores, various bacteria and viruses to be greatly propagated and float in the air to enter human bodies through respiratory tracts; modern furniture, indoor decoration and decoration materials carry harmful carcinogenic substances such as formaldehyde and the like to erode the health of human beings; once a year or two years, epidemic diseases caused by bacteria and viruses on a large scale, and the like, which seriously affect the health of human beings. Meanwhile, as the income of people increases, the demand and consumption for health are also increasing. According to related reports, the consumption scale of domestic health care products in the market currently reaches 1000 million yuan, and the consumption scale of the national health care products reaches 4000 million yuan by 2020. And people needing to improve immunity basically occupy about 20 percent of market share.
The improvement of the immunity of the human body can be achieved by means of balancing proper nutrition, paying attention to rest, exercising frequently, giving up bad dietary habits, smoking and drinking, relaxing the mood and the like, but most of people need to take the product for improving the immunity to improve the immunity of the organism.
Immunity refers to the ability of the body to resist external attack and maintain the stability of the environment in the body. Humans can exhibit reduced immunity in the presence of disease, excessive exertion, environmental stress, genetics, and the like. Because the cause of immunity is complex, the medical field at present is divided into non-specific immunity and specific immunity or congenital immunity and acquired immunity, so the immunity-improving product is also in shape and color, wherein, some nutrients such as protein powder, amino acid and vitamins can be supplemented; the traditional Chinese medicine product not only is a common variety such as rhodiola rosea essence oral liquid and human royal jelly, but also is a kidney tonifying product.
At present, natural products and some nutritional products capable of improving human immunity are abundant, up to hundreds of patent applications related to improving immunity in a Chinese patent database are provided, related medicines comprise dozens of medicines such as ginseng, acanthopanax, epimedium, American ginseng, rhodiola rosea, cordyceps sinensis, royal jelly, medlar, pilose antler and the like, related chemical medicines comprise taurine, vitamin C, vitamin B1, vitamin B6, mineral substances and the like, wherein the formula is represented as follows:
the invention patent application with publication number CN1439412A discloses a medicine for improving immunity, which is prepared from radix astragali, rhizoma Polygonati, fructus Psoraleae, fructus Ligustri Lucidi, fructus Schisandrae chinensis and Concha Ostreae by making into oral liquid according to different characteristics of each Chinese medicinal material.
The patent application with the publication number of CN1394631A discloses an anti-fatigue health-care product, which is powder prepared from calcium pyruvate, high-quality ginseng, astragalus root, taurine, zinc gluconate, vitamin C and excipient starch.
However, because the cause of low immunity is complex and the treatment mechanism and the conditioning mechanism are many, the medicine for improving immunity with multiple links, multiple layers and multiple targets needs to be developed by taking the advantages of the traditional Chinese medicine into consideration.
Disclosure of Invention
The invention aims to solve the technical problem of providing the pharmaceutical composition for improving the immunity, and the pharmaceutical composition has the advantages of simple and special medicament and remarkable curative effect.
The technical scheme for solving the technical problems is as follows:
the pharmaceutical composition for improving the immunity comprises effective components and auxiliary materials, wherein the effective components are prepared from the following raw material medicines in parts by weight: 1-2 parts of pseudo-ginseng, 4-8 parts of polygonatum odoratum, 4-8 parts of lily, 4-8 parts of bighead atractylodes rhizome and 4-8 parts of wolfberry fruit.
The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 1.5 parts of pseudo-ginseng, 6 parts of polygonatum odoratum, 6 parts of lily, 6 parts of bighead atractylodes rhizome and 6 parts of wolfberry fruit.
In the above scheme, the effective components can be prepared by a conventional method, and the water extraction method recommended by the inventor is as follows:
(1) respectively adding water into polygonatum odoratum, lily, bighead atractylodes rhizome and wolfberry fruit, decocting twice, adding 10 times of water into the first time, soaking for 0.5h, decocting for 2.0h, adding 8 times of water into the second time, decocting for 1.0h, combining the two decoctions, filtering, performing tubular centrifugation on the filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of the temperature of 60 ℃ and the vacuum degree of-0.08 Mpa to obtain extract powder;
(2) pulverizing Notoginseng radix, and sieving with 200 mesh sieve to obtain Notoginseng radix powder; alternatively, the first and second electrodes may be,
respectively adding water into pseudo-ginseng, decocting twice, adding 10 times of water into the pseudo-ginseng for the first time, soaking for 0.5h, then decocting for 2.0h, adding 8 times of water into the pseudo-ginseng for the second time, decocting for 1.0h, combining the two decoctions, filtering, carrying out tubular centrifugation on the filtrate at 16000rpm, concentrating the centrifugal liquid to obtain a thick paste with the relative density of 1.30-1.35 at 60 ℃, and then carrying out vacuum drying or spray drying under the conditions that the temperature is 60 ℃ and the vacuum degree is-0.08 Mpa to obtain a pseudo-ginseng aqueous extract;
(3) and (3) uniformly mixing the extract powder prepared in the step (1) with the pseudo-ginseng powder or pseudo-ginseng aqueous extract prepared in the step (2) to obtain the effective component.
The above effective components can be mixed with pharmaceutically acceptable adjuvants to make into various common oral preparations, such as granule, tablet, capsule or oral liquid.
The pharmaceutical composition is prepared from pure natural raw material medicines, and the influence test of a mouse on an immune system proves that the pharmaceutical composition has an obvious effect of enhancing the immune function of the mouse, and is suitable for being taken by people with low immunity caused by diseases, weak constitution, overwork, bad environment and the like.
The traditional Chinese medicine considers that the healthy qi exists in the interior and the pathogenic factors cannot be dried. If the healthy qi of the human body is sufficient, the resistance and the immunity are strong, and the disease is not easy to get. The qi of the human body is divided into the superficial qi and the internal qi, and the traditional Chinese medicine invigorates qi and focuses on both internal and external tonics. Meanwhile, qi, blood and yin and yang of a human body are mutually transformed, so that the immunity is improved, and the traditional Chinese medicine considers that the whole body is regulated, and the disease resistance of the human body is integrally regulated by regulating qi, blood and yin and yang. The problems of blood stasis, blood deficiency and the like can cause hypoimmunity, and when blood circulation is promoted, blood stasis is removed, and blood is promoted and enriched. The traditional Chinese medicine has the effects of conditioning the body or treating diseases, mainly conditioning yin and yang of the human body, achieving the aim of relatively balancing yin and yang of the human body, dredging channels and collaterals, ensuring the smoothness of qi and blood, stabilizing emotion, improving the mental state of anxiety and tension, simultaneously reducing the muscle tension of the whole body, and achieving the state of coordinating and unifying the functions of viscera and tissues, thereby relieving the physical and mental pressure of a patient, and playing a positive promoting role in recovering the functions of the heart and the lung of the patient and adjusting the emotion. In addition, dampness is pathogenic qi, and a large amount of internal dampness can also cause the decline of immunity when resolving dampness and promoting diuresis. Therefore, the traditional Chinese medicine can improve the immunity of the patients by the methods of promoting blood circulation, dredging collaterals, tonifying exterior and interior qi, relieving yin deficiency and yang deficiency, inducing diuresis and eliminating dampness and the like.
The pharmaceutical composition comprises pseudo-ginseng, radix polygonati officinalis, lily, bighead atractylodes rhizome and wolfberry fruit, wherein the pseudo-ginseng is used as a monarch drug for removing blood stasis, stopping bleeding, relieving swelling and pain, promoting blood circulation, tonifying qi and enriching blood; the polygonatum and the bighead atractylodes rhizome are used as ministerial drugs and help monarch drugs to tonify qi and nourish yin, activate blood and enrich blood and tonify internal organs; the lily and the medlar are used as adjuvant drugs to replenish qi and nourish heart. The medicines have the effects of promoting blood circulation, enriching blood, tonifying qi, promoting diuresis, invigorating spleen, nourishing heart and tonifying kidney, and are most suitable for qi and blood deficiency syndromes of low immunity, qi and blood deficiency, qi and blood stagnation and lung qi deficiency.
The effects of the present invention will be demonstrated by experiments.
The test is based on a commonly used test for enhancing immunity, and the mice taking the pharmaceutical composition of the present invention are observed.
Research on immunity improving effect of mice
1 reagents and materials
1.1 test subjects: kunming old mice (10 months old) with the weight of 18-22 g and males.
1.2 test samples:
test sample 1: is the capsule of example 1 below.
Test sample 2: the granules of example 2 below were prepared.
Test sample 3: the tablet of example 3 below.
Test sample 4: the oral liquid of the following example 4.
1.3 grouping and administration
The test samples were randomly divided into 5 groups of 50, which were blank control (normal) and test sample 1, 2, 3, 4 groups, respectively. The above-mentioned ingredients are respectively converted according to human dose (adopting general dose conversion method, and concretely, it is referred to: Chenqi. Chinese medicine pharmacological research methodology. Beijing: people's health publishing company [ M ]. 2006: 116), and added with proper quantity of water for dissolving mouse dose and making it be used for gastric perfusion. Each group of animals freely drunk 0.1% BSA acidified water in the test process, the blank group was infused with normal saline daily, and the other 3 groups were infused with test samples 1 time daily for 30 consecutive days.
2 methods and results
2.1 organ/body weight ratio measurement: at the end of the experiment, 10 mice were taken, weighed, sacrificed, the thymus and spleen removed, weighed on an electronic analytical balance, and the visceral/somatic ratio calculated. The results are shown in Table 1 below.
2.2 mouse DTH test induced by dinitrofluorobenzene (hereinafter referred to as DNFB) (ear swelling method): 10 mice were each depilated on the abdominal skin of each group 5 days before the end of the test, and then sensitized by applying 50. mu.l of DNFB solution, 10. mu.l of DNFB was applied to both sides of the right ear of the mouse after 5 days for challenge, and after 24 hours, the mice were sacrificed, and 8mm diameter ear pieces of the left and right ear shells were removed by a punch and weighed, and the degree of DTH was expressed as the difference between the weights of the two ear pieces. The results are shown in Table 1 below.
2.3 mouse carbon clearance test: 10 mice in each group were injected with India ink 4-fold diluted by tail vein 1h after the last administration, 0.1ml per 10g body weight was injected, timing immediately after the injection, 20 μ l of blood was taken from the angular venous plexus in the eye at the 2 nd and 10 th minutes after the injection, and added to 2ml of 0.1 Na2CO3Shaking up in the solution. With Na2CO3The solution was used as a blank control and the Optical Density (OD) was measured at a wavelength of 600nm using a semi-automatic biochemical analyzer. Mice were sacrificed, livers and spleens were removed, weighed, and phagocytic index was calculated. The results are shown in Table 2 below.
2.4 phagocytosis of chicken erythrocytes by mouse abdominal macrophages (in vivo method): at the end of the test, 10 mice in each group were intraperitoneally injected with 20% (v/v, prepared with normal saline) of packed chicken red blood cell suspension, 1ml of each mouse was injected, the mice were sacrificed at intervals of 30min by cervical dislocation, and the phagocytosis rate and phagocytosis index were calculated by detection according to the "in vivo method". The results are shown in Table 2 below.
2.5NK cell Activity assay: continuously administering for 30 days, killing cervical vertebra by dislocation, collecting spleen to obtain cell suspension (effector cell), adding YAC-1 cell 24h after passage into PRMI1640 complete culture solution, and adjusting cell concentration to 4 × 105ml-1(target cell), 100. mu.l each of target cell and effector cell (50: 1 effective target ratio) was taken and added to a U-shaped 96-well plate, 100. mu.l each of target cell and culture medium was added to a natural release hole of target cell, 100. mu.l each of target cell and NP40 was added to a maximum release hole, three duplicate wells were set for each, and the culture was incubated at 37 ℃ with 5% CO2Culturing in incubator for 4h, sucking 100 μ L supernatant per well, placing in flat-bottomed 96-well culture plate, adding 100 μ L Lactate Dehydrogenase (LDH) matrix solution, reacting for 3min, and adding 1 mol. L per well-1Was stopped with 30. mu.l of HCl and the optical density value (OD) was determined at 490nm using a microplate reader. The results are shown in Table 2.
TABLE 1 Change in immune parameters of groups of mice given 30 days
P <0.05, blank control group compared to test samples 1-4.
TABLE 2 Change in immune parameters of groups of mice given 30 days
P <0.05, blank control group compared to test samples 1-4.
The results show that the influence of the sample on the ratio of the organ/body weight of the immune organ indicates that: in the test, the growth conditions of the mice in each group are good, and physiological signs, appearances, behaviors and the like are not abnormal. The thymus/body weight and spleen/body weight ratio of different sample groups are tested to be different from the control group, and the difference is not statistically significant (P is more than 0.05); the weight difference of the left and right ear pieces of the mice in the sample group in the delayed type allergy (DTH) test is higher than that of the negative control group, the difference is statistically significant (P is less than 0.05) compared with the control group, and the result of the cellular immune test is judged to be positive. The results of the effect of the samples on the phagocytic function of mononuclear macrophages in mice indicate that: the phagocytosis index of the carbon clearance test of the mouse mononuclear macrophage in each dosage of the sample is higher than that of the control group, and the difference of each sample group and the negative control group has statistical significance (P is less than 0.05); compared with a negative control group, the phagocytosis rate and the phagocytosis index of abdominal cavity macrophages of a sample group mouse on chicken erythrocytes have no statistical significance (P is more than 0.05), but each sample group is higher than the negative control group in numerical view, so that the test result is integrally shown to be positive, and the sample has a promotion effect on the phagocytosis function of mononuclear macrophages of the mouse; compared with the negative control group, the NK cell activity of the mice in the sample group has no statistical significance (P is more than 0.05), but the sample group is higher than the negative control group in numerical view, which indicates that the sample has certain improvement effect on the NK cell activity.
The test result shows that the pharmaceutical composition has obvious enhancement effect on the immune function of mice.
Detailed Description
Example 1
1. Prescription: 1.5g of pseudo-ginseng, 4g of polygonatum odoratum, 6g of lily, 8g of bighead atractylodes rhizome and 5g of wolfberry fruit.
2. The preparation method comprises the following steps:
decocting polygonatum odoratum, lily, bighead atractylodes rhizome and wolfberry fruit with water twice, adding 10 times of water for the first time, soaking for 0.5h, decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, performing tubular centrifugation on filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of 60 ℃ and vacuum degree of-0.08 Mpa to obtain extract powder;
pulverizing Notoginseng radix, and sieving with 200 mesh sieve to obtain Notoginseng radix powder;
and adding the extract powder into the pseudo-ginseng powder and proper auxiliary materials, uniformly mixing, granulating, and filling into 8 capsules to obtain the capsules.
3. The taking method comprises the following steps: it is administered orally 4 granules at a time, 2 times daily.
Example 2
1. Prescription: 1.5g of pseudo-ginseng, 6g of polygonatum odoratum, 6g of lily, 6g of bighead atractylodes rhizome and 6g of wolfberry fruit.
2. The preparation method comprises the following steps:
decocting polygonatum odoratum, lily, bighead atractylodes rhizome and wolfberry fruit with water twice, adding 10 times of water for the first time, soaking for 0.5h, decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, performing tubular centrifugation on filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of 60 ℃ and vacuum degree of-0.08 Mpa to obtain extract powder;
pulverizing Notoginseng radix, and sieving with 200 mesh sieve to obtain Notoginseng radix powder;
mixing the extract powder with Notoginseng radix powder and appropriate adjuvant, and making into granule 20 g.
3. The taking method comprises the following steps: it is administered orally at a dose of 10g once and 2 times daily.
Example 3
1. Prescription: 1g of pseudo-ginseng, 4g of polygonatum odoratum, 8g of lily, 4g of bighead atractylodes rhizome and 8g of wolfberry fruit.
2. The preparation method comprises the following steps:
decocting polygonatum odoratum, lily, bighead atractylodes rhizome and wolfberry fruit with water twice, adding 10 times of water for the first time, soaking for 0.5h, decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, performing tubular centrifugation on filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of 60 ℃ and vacuum degree of-0.08 Mpa to obtain extract powder;
pulverizing Notoginseng radix, and sieving with 200 mesh sieve to obtain Notoginseng radix powder;
mixing the extract powder with Notoginseng radix powder and appropriate adjuvant, granulating, and tabletting to obtain 10 tablets.
3. The taking method comprises the following steps: it is administered orally 5 tablets at a time, 2 times daily.
Example 4
1. Prescription: 2g of pseudo-ginseng, 8g of polygonatum odoratum, 4g of lily, 5g of bighead atractylodes rhizome and 4g of wolfberry fruit.
2. The preparation method comprises the following steps:
decocting the polygonatum odoratum, the lily, the bighead atractylodes rhizome and the wolfberry fruit twice by adding water, adding 10 times of water for the first time, soaking for 0.5h, decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, performing tubular centrifugation on the filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying at the temperature of 60 ℃ and the vacuum degree of-0.08 Mpa to obtain extract powder;
decocting pseudo-ginseng twice with water, adding 10 times of water for the first time, soaking for 0.5h, then decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, carrying out tubular centrifugation on the filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and then carrying out vacuum drying or spray drying under the conditions of the temperature of 60 ℃ and the vacuum degree of-0.08 Mpa to obtain the pseudo-ginseng aqueous extract.
Dissolving the extract powder and Notoginseng radix water extract in water, adding appropriate amount of additive, mixing, adding water, and metering to 20ml to obtain oral liquid.
3. The taking method comprises the following steps: it is administered orally at a dose of 10ml each time, 2 times a day.
Claims (3)
1. A pharmaceutical composition for improving immunity is composed of the following raw materials in parts by weight: 1-2 parts of pseudo-ginseng, 4-8 parts of polygonatum odoratum, 4-8 parts of lily, 4-8 parts of bighead atractylodes rhizome and 4-8 parts of wolfberry fruit.
2. The composition of claim 1, wherein the optimum ratio of the raw materials is notoginseng 1.5, polygonatum 6, lily 6, atractylodes 6, lycium 6.
3. The composition according to claim 1 or 2, wherein the composition is prepared by the following method:
(1) decocting polygonatum odoratum, bighead atractylodes rhizome, lily and wolfberry fruit with water twice, soaking the polygonatum odoratum, bighead atractylodes rhizome, lily and wolfberry fruit in 10 times of water for 0.5h for the first time, decocting the polygonatum odoratum, bighead atractylodes rhizome, lily and wolfberry fruit in 8 times of water for the second time for 1.0h, filtering, performing tubular centrifugation on filtrate at 16000rpm, concentrating the centrifugal liquid to thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of the temperature of 60 ℃ and the vacuum degree of-0.08 Mpa to obtain extract powder;
(2) pulverizing Notoginseng radix, and sieving with 200 mesh sieve to obtain Notoginseng radix powder; or decocting pseudo-ginseng twice with water, soaking the pseudo-ginseng twice with 10 times of water for 0.5h, decocting for 2.0h, adding 8 times of water for the second time, decocting for 1.0h, filtering, performing tubular centrifugation on the filtrate at 16000rpm, concentrating the centrifugate to obtain a thick paste with the relative density of 1.30-1.35 at 60 ℃, and performing vacuum drying or spray drying under the conditions of the temperature of 60 ℃ and the vacuum degree of-0.08 Mpa to obtain the pseudo-ginseng extract;
(3) and (3) uniformly mixing the extract powder prepared in the step (1) with the pseudo-ginseng powder or pseudo-ginseng aqueous extract prepared in the step (2).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1109353A (en) * | 1994-03-31 | 1995-10-04 | 徐祖德 | Prescription for defatting and hypotensor capsule and its making method |
| CN103211220A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of enhancing immunity and preparation method thereof |
| CN104223086A (en) * | 2014-09-30 | 2014-12-24 | 九仙尊霍山石斛股份有限公司 | Composite dendrobium huoshanense lozenge and preparation method thereof |
-
2020
- 2020-05-12 CN CN202010395653.XA patent/CN111346172B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1109353A (en) * | 1994-03-31 | 1995-10-04 | 徐祖德 | Prescription for defatting and hypotensor capsule and its making method |
| CN103211220A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of enhancing immunity and preparation method thereof |
| CN104223086A (en) * | 2014-09-30 | 2014-12-24 | 九仙尊霍山石斛股份有限公司 | Composite dendrobium huoshanense lozenge and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 益气养阴祛瘀中药治疗干燥综合征的临床疗效及其对免疫功能的影响;吴国琳等;《中国中西医结合杂志》;20060420;第26卷(第04期);第322-324页 * |
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| CN111346172A (en) | 2020-06-30 |
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