CN103877263B - A kind of antifatigue health preparation of the compound Chinese medicine such as red ginseng, maca, green-tea extract (theanine) - Google Patents
A kind of antifatigue health preparation of the compound Chinese medicine such as red ginseng, maca, green-tea extract (theanine) Download PDFInfo
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Abstract
The present invention relates to a kind of antifatigue health preparation of Chinese medicine, said preparation is prepared by the bulk drug of following parts by weight：Red ginseng 1 15, maca 10 50, the Radix Astragali 10 50, Radix Angelicae Sinensis 5 30, dried orange peel 1 15, green-tea extract (theanine) 1 15.The rules for the treatment of of this preparation based on traditional Chinese medical theory and modern medicine theory to chronic fatigue syndrome, chronic fatigue syndrome symptom is related to limbs fatigue, hyposexuality, arthralgia, head carbuncle, forgetful, depressed, insomnia, thinking difficulty etc., belong to sub-health state, the traditional Chinese medical science is called " slack ", " slack lazy ", " four limbs overstrain ", " inability to raise limbs " and " four limbs are not intended to move " etc..Red ginseng, Radix Astragali air making-up and spleen enlivening blood-nourishing in this preparation, the Radix Angelicae Sinensis thoughts of returning home, liver, the spleen channel replenishing and activating blood, dried orange peel regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, maca, green-tea extract (theanine) directly antifatigue, antidepression, relaxation nerve, anti-insomnia, increase memory.Six medicines share, and play that invigorating spleen and nourishing heart, which is calmed the nerves, qi-regulating is soothing the liver enriches blood altogether, regulation organism endocrine, excite nerve, all systems of body fluid independently coordinate mutually with function, reach the fatigue-relieving symptom related to alleviation chronic fatigue syndrome.
Description
Technical field
The present invention relates to a kind of field of Chinese medicinal composition, specially a kind of red ginseng, maca, green-tea extract (theanine) etc.
The antifatigue health preparation of compound Chinese medicine.
Background technology
Fatigue is a subjective sensation symptom, refers to a kind of burnout, energy not enough or the used-up sensation in the whole body.Someone
Fatigue is divided into two aspects of mental fatigue and physical fatigue, mental fatigue is a kind of amotivational and subjective sensation of vigilance,
Show as having one's head in the clouds, doing things, it is difficult to be not easy to focus on or even think deeply, and forgetful, desire declines, error-prone in work, work
Efficiency decline etc..Physical fatigue is to feel that muscle lacks energy or strength, often shows as holding after carrying out certain physical exertion
Fatiguability, or fatigue are not easy to disappear, or even influence daily life and work to some extent.Clinically, fatigue is one normal
The very wide symptom of seeing, non-specific, coverage, can be the cardinal symptom of a variety of diseases or the simultaneous phenomenon of many diseases.
The Center for Disease Control (CDC) will continue in 1994 or the fatigue of recurrent exerbation 6 months or longer time be defined as it is " chronic
Fatigue ".
Chronic fatigue syndrome does not have record corresponding thereto in TCM Document.But fatigue is used as in tcm clinical practice often
The symptom seen, it is commonly described as " slacking off " in Chinese medical book, " slack lazy ", " four limbs overstrain ", " inability to raise limbs " and " four limbs are not intended to
It is dynamic " etc., the descriptions such as " whole body is weak ", " four limbs burnout ", " spiritlessness and weakness " are used in modern Chinese medicine clinic.By traditional Chinese medical science science of visceral state
Say, the weak and fatiguability of body and spleen, liver, kidney three is dirty direct relation.
Although prior art is related to use Chinese medicine composition to carry out the research to treating chronic effort syndrome, mechanism
Indefinite, effect is also each variant.The present invention is attempted air making-up and spleen enlivening blood-nourishing, replenishing and activating blood, regulating qi-flowing for strengthening spleen, directly antifatigue,
Antidepression, relaxation nerve, anti-insomnia, the drug combination of increase memory, reach fatigue-relieving and alleviate chronic fatigue syndrome phase
The symptom of pass.Wherein：
Red ginseng
This product is dry roots and rhizome of the Araliaceae ginseng PanaxginsengC.A.Mey. after steaming.It is sweet, micro-
Hardship, temperature.Returns spleen, lung, the heart, kidney channel.Strengthening by means of tonics, invigorating the blood, promote the production of body fluid to quench thirst, mental-tranquilization is antifatigue, improves women climacteric
Phase syndrome.《Sheng Nong's herbal classic》Described in：Tonifying five zang organs, soothe the nerves, determine soul, stop palpitate with fear, remove pathogenic factor, improving eyesight, happy, benefit
Intelligence, long term usage are made light of one's life by commiting suicide macrobiosis.Ginseng after processing main active changed, in ginseng the larger saponin(e of content into
Re, Rc etc. such as is divided to convert for content in ginseng few rare ginsenoside constituents such as Rg3, Rs etc., the property of medicine is gentle.It is modern
Pharmacological research proves, red ginseng regulation nerve, stimulates the circulation of peripheral blood liquid, improves heart failure, regulation endocrine, promotion property machine
Can, it is antifatigue, improve female climacteric syndrome effect, anti-ageing wait for a long time.
Maca
This product is Cruciferae (Cruciferae) Lepidium (Lepidium) plant, originate in height above sea level 3500~
4500m South America andes region, primarily now it is distributed in middle part and the southeastern city of of Peru.Maca is gone through in the edible of South America
History is existing more than 5800 years, and as traditional food and herbal medicine, it can improve sexual function, improve fertility, antifatigue, anticancer, resists
Depressed, treatment climacteric metancholia etc..Maca contains abundant protein, amino acid, reduced sugar, mineral matter, unsaturated fat
The anti-fatigue nutrient material such as acid, especially taurine, mineral matter zinc, branched-chain amino acid (leucine, valine, isoleucine),
They play an important role in motor center fatigue and organism fatigue is eliminated.Abundant nutritive value, pure natural medicinal plant
Characteristic, the edible security of tradition makes maca fashionable in international market within thousands of years.
1992 --- FAO's Rome declaration is using maca (Maca) as a kind of rare nutritious supplementary pharmaceutical
Recommend to the world.
1992 --- maca (Maca) is classified as rare plant by International Plant Genetic Resources Institute.
1998 --- America fitoterapia research institute publishes maca (Maca) monograph《Agate card (Maca) Peru is medicinal and seeks
Support plant》.
2001 --- FDA Food and Drug Administration (FDA) has passed through maca (Maca) health medicine into the U.S.
Demonstration.
2001 --- the U.S. is that the two kinds of novel substances found in maca (Maca) are named as agate card alkene and macamides.
2001 --- Xiao member of Chinese Academy of Engineering Baconic《The health food that MACA mono- attractes attention in the whole world》One text is delivered.
Green-tea extract (theanine)
This product is obtained by Hydrolysis kinetics in common green tea, and theanine is its main composition.Theanine (L-
Theanine it is) a kind of special amino acid for containing in tealeaves, medicine accounts for the 50% of free amino acid of tea total amount, modern study
Having proven to theanine has different physiological roles, and 1. theanine can be obviously promoted mesencephalic centre dopamine D_2 receptors, and it is more to improve intracerebral
Bar amine physiologically active, dopamine are the emotion shapes of a kind of central neurotransmitter for activating cranial nerve cell, its physiologically active and people
State is closely related, therefore body calm nerves can be made nervous, happy；2. dopamine is also adrenaline and norepinephrine
Synthesis precursor, be to passing on the material that plays an important role of cranial nerve cell excitement, and the change of transmitter substance can influence
Learning ability, memory etc.；3. delayed motion fatigue；4. improve sleep；5. protect liver；6. improve premenstrual syndrome.
The Radix Astragali
This product is the dry root of legume Mongolia Huang or Astragalus membranacus.It is sweet, tepor.Return lung, the spleen channel.The traditional Chinese medical science thinks, yellow
Stilbene can mend the gas of the whole body, have rising Yang, strengthening exterior and reducing sweat, apocenosis myogenic, inducing diuresis for removing edema, the effect of antiabortive beneficial blood concurrently.For anaemia, float
Swollen, body void hidrosis, fetal irritability, the prolapse of uterus, qi-blood deficiency, deficiency of Yin deficiency etc. have the effect of distinguished.Singly take the Radix Astragali soaked
Drink, it is sleepy to control body, powerless, shortness of breath.After Mr.'s Hu Shi middle age, feel dog-tired gradually, it is unable to do what one wishes, just commonly use the Radix Astragali
It is soaked to use on behalf of the tea.Particularly before teaching, youngster's mouth Radix Astragali water is always first sipped, so that energy doubles, says words sound such as flood
Clock, speak unceasingly.
Modern pharmacology research shows that the Radix Astragali contains the plurality of active ingredients such as glucoside, polysaccharide, amino acid and trace element, tool
Have cardiac stimulant, resist myocardial ischemia, strengthen humoral immunity and cellular immunity and antiviral, hypoglycemic, antioxidant and anti-aging, be antifatigue,
Protect the effect such as liver.
Radix Angelicae Sinensis
This product is umbelliferae angelica Angelicasinensis (Oliv.) Diels. dry root.Sweet, acrid, warm.Return
Liver, the heart, the spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, relax bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, asthenia cold abdominalgia
Deng.In first, China Herbal Textuals works《Sheng Nong's herbal classic》In be listed in can eliminating evil again can qi-restoratives middle product.《Jing Yuequan
Book-book on Chinese herbal medicine is just》In say：" Radix Angelicae Sinensis, its is sweet and weighs, therefore can specially enrich blood；Its gas is light and pungent, therefore and can promoting circulation of blood.Bowl spares has, OK
In have a benefit, the gas medicine in sincere blood, the also panacea in blood ".Modern study shows, volatile oil, carbohydrate, ammonia are mainly contained in Radix Angelicae Sinensis
The chemical compositions such as base acid, organic acid, there is anti-inflammatory, scavenging activated oxygen, hepatic cholagogic, protection kidney, enhancing immunologic function, anti-
The multiple efficacies such as fatigue act on.
Dried orange peel
This product is rutaceae orange CitrusreticulataBlanco and its dry mature skin of variety,
It is bitter, pungent, temperature, return lung, spleen, Liver Channel, there is the effect of appetizing in regulating QI and lowering the adverseness, tune, eliminating dampness and eliminating phlegm, cure mainly retention of dampness due to stagnation of QI, chest diaphragm
Full vexed, gastral cavity abdomen is swollen sieve, do not feel like eating, vomit the diseases such as hiccup, difficulty in urination and defecation, lung qi retardance, coughing with a lot of sputum.《Compendium of Materia Medica》In
Shi Zhen is said：Orange peel, is then mended with tonic, is then rushed down with cathartic, is then risen with hydrargyrum oxydatum crudum, with drop medicine then drop, but with match somebody with somebody and reinforcing and reducing methods lift.
And it is summarized as：It controls all kinds of diseases and ailments, always takes the work(of its qi-regulating eliminating dampness.Dried orange peel is mainly containing volatile oil, flavonoids, alkaloid, inositol etc.
Composition, modern pharmacological research show that 1. can effectively improve and improve digestive functions；2. improve physical stress ability；3. carry
High immunity, anti-allergic effects；4. antifatigue, antioxidant and anti-aging；Deng effect.
The content of the invention
The rules for the treatment of of this preparation based on traditional Chinese medical theory and modern medicine theory to chronic fatigue syndrome, confirmed fatigue are comprehensive
Simulator sickness symptom is related to limbs fatigue, hyposexuality, arthralgia, head carbuncle, forgetful, depressed, insomnia, thinking difficulty etc., belongs to sub-
Health status, the traditional Chinese medical science are called " slack ", " slack lazy ", " four limbs overstrain ", " inability to raise limbs " and " four limbs are not intended to move " etc..This preparation
Middle red ginseng, Radix Astragali air making-up and spleen enlivening blood-nourishing, the Radix Angelicae Sinensis thoughts of returning home, liver, the spleen channel, replenishing and activating blood is dried orange peel regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, maca,
Green-tea extract (theanine) directly antifatigue, antidepression, relaxation nerve, anti-insomnia, increase memory.Six medicines share, and play altogether strong
Spleen mental-tranquilization, qi-regulating is soothing the liver enriches blood, regulation organism endocrine, excite nerve, all systems of body fluid independently coordinate mutually with function,
Reach the fatigue-relieving symptom related to chronic fatigue syndrome is alleviated.
Realize that the present composition of above effect adopts the following technical scheme that：
A kind of antifatigue health preparation of Chinese medicine, said preparation are prepared by the bulk drug of following parts by weight：Red ginseng 1-15, agate
Coffee 10-50, Radix Astragali 10-50, Radix Angelicae Sinensis 5-30, dried orange peel 1-15, green-tea extract 1-15.
Preferably, it is prepared by the bulk drug of following parts by weight：Red ginseng 5-10, maca 20-40, Radix Astragali 20-40, Radix Angelicae Sinensis
10-20, dried orange peel 5-10, green-tea extract 5-10.
Preferably, it is prepared by the bulk drug of following parts by weight：Red ginseng 5-8, maca 25-30, Radix Astragali 35-40, Radix Angelicae Sinensis
15-20, dried orange peel 8-10, green-tea extract 5-8.
Preferably, it is prepared by the bulk drug of following parts by weight：Red ginseng 5, maca 25, the Radix Astragali 40, Radix Angelicae Sinensis 15, dried orange peel
10th, green-tea extract 5.
The preparation method of the antifatigue health preparation of described Chinese medicine comprises the following steps：
Red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine add 8-12 times to measure water boiling and extraction 2-4 times, each 1-3h；It will carry
Take liquid to carry out being concentrated under reduced pressure into thick medicinal extract and be dried in vacuo and crushed 80 mesh sieves, obtain five kinds of Chinese medicine extraction powder；With green tea
Extract is well mixed, and then prepares suitable formulation；Wherein, described green-tea extract preparation technology is：Under the conditions of 50-70 degree
Water extracts 1-3 times, each 1-3h, is concentrated under reduced pressure, sterilizes, is spray-dried, crushed 80 mesh sieves and produce through flocculating, filtering.
Preferably, the preparation method of the antifatigue health preparation of described Chinese medicine comprises the following steps：
Red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine add 10 times to measure water boiling and extraction 3 times, each 1.5h；By extract solution
Carry out being concentrated under reduced pressure into thick medicinal extract and be dried in vacuo and crushed 80 mesh sieves, obtain five kinds of Chinese medicine extraction powder；Extracted with green tea
Thing is well mixed, and then prepares suitable formulation；Wherein, described green-tea extract preparation technology is：Water extraction 2 under the conditions of 60 degree
It is secondary, each 2h, it is concentrated under reduced pressure, sterilizes, is spray-dried, crushed 80 mesh sieves and produce through flocculating, filtering.
Embodiment
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by specific reality
Any restrictions of example are applied, but are defined in the claims.
Embodiment 1
A kind of antifatigue health preparation of Chinese medicine, it is that red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine are added into 8 times of amount water
Decoct extraction 4 times, each 1h；Extract solution is carried out being concentrated under reduced pressure into thick medicinal extract and is dried in vacuo and crushed 80 mesh sieves,
Obtain five kinds of Chinese medicine extraction powder；It is well mixed with green-tea extract, then adds appropriate magnesium stearate direct tablet compressing and produce tablet, often
Piece weight 0.5g.
Wherein, described green-tea extract preparation technology is：Water extracts 3 times, each 3h under the conditions of 70 degree, through flocculation, mistake
Filter is concentrated under reduced pressure, sterilized, being spray-dried, crushed 80 mesh sieves and produce.
Wherein, the weight ratio of each bulk drug is：Red ginseng 8, maca 30, the Radix Astragali 40, Radix Angelicae Sinensis 40, dried orange peel 12, green-tea extract
5。
Embodiment 2
A kind of antifatigue health preparation of Chinese medicine, it is that red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine are added into 12 times of amount water
Decoct extraction 4 times, each 3h；Extract solution is carried out being concentrated under reduced pressure into thick medicinal extract and is dried in vacuo and crushed 80 mesh sieves,
Obtain five kinds of Chinese medicine extraction powder；It is well mixed with green-tea extract, appropriate dextrin, sucrose, mixed pelletization, is drying to obtain granule.
Wherein, described green-tea extract preparation technology is：Water extracts 3 times, each 2h under the conditions of 50 degree, through flocculation, mistake
Filter is concentrated under reduced pressure, sterilized, being spray-dried, crushed 80 mesh sieves and produce.
Wherein, the weight ratio of each bulk drug is：Red ginseng 10, maca 20, the Radix Astragali 40, Radix Angelicae Sinensis 20, dried orange peel 10, green-tea extract
10。
Embodiment 3
A kind of antifatigue health preparation of Chinese medicine, it is that red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine are added into 10 times of amount water
Decoct extraction 3 times, each 2h；Extract solution is carried out being concentrated under reduced pressure into thick medicinal extract and is dried in vacuo and crushed 80 mesh sieves,
Obtain five kinds of Chinese medicine extraction powder；It is well mixed with green-tea extract, appropriate dextrin, sucrose, mixed pelletization, is drying to obtain granule.
Wherein, described green-tea extract preparation technology is：Water extracts 2 times, each 2h under the conditions of 60 degree, through flocculation, mistake
Filter is concentrated under reduced pressure, sterilized, being spray-dried, crushed 80 mesh sieves and produce.
Wherein, the weight ratio of each bulk drug is：Red ginseng 8, maca 30, the Radix Astragali 40, Radix Angelicae Sinensis 15, dried orange peel 10, green-tea extract
10。
Embodiment 4
A kind of antifatigue health preparation of Chinese medicine, it is that red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine are added into 10 times of amount water
Decoct extraction 3 times, each 1.5h；Extract solution is carried out being concentrated under reduced pressure into thick medicinal extract and is dried in vacuo and crushed 80 mesh
Sieve, obtain five kinds of Chinese medicine extraction powder；It is well mixed with green-tea extract, direct encapsulating capsule, every capsule content containing 0.4g.
Wherein, described green-tea extract preparation technology is：Water extracts 2 times, each 2h under the conditions of 60 degree, through flocculation, mistake
Filter is concentrated under reduced pressure, sterilized, being spray-dried, crushed 80 mesh sieves and produce.
Wherein, the weight ratio of each bulk drug is：Red ginseng 5, maca 25, the Radix Astragali 40, Radix Angelicae Sinensis 15, dried orange peel 10, green-tea extract
5。
The experimental example of embodiment 5
1 sample：Capsule (hereinafter referred to as sample) prepared by embodiment 4.Everyone (adult) 2 times a day, 3 tablets each time, is grown up
Body weight is calculated by 60kg, and it is 40mg/kgBW to convert into dosage.
2 result of the tests
Influence of 2.1 samples to mouse weight
1, table 2 is the results are shown in Table, the original body mass of mouse is in each experimental group compared between negative control group, and difference is without aobvious
Work property (P>0.05), i.e., the original body mass of mouse is more balanced between each group.
The body weight increase situation of each group mouse of table 1
The body weight increase situation of each group mouse of table 2
Note：Each dosage group tests initial, mid-term and the mouse weight in latter stage and weightening compared with control group, and difference nothing shows
Work property (P>0.05).
After table 1,2, the sample 30d of orally administration mouse various dose, each dosage of sample of antifatigue I-IV groups
The body weight of group is compared with mean between negative control group, the difference of each dosage group and negative control group there are no significant (P>0.05),
Show the sample on the body weight increase of mouse without influence.
Influence of 2.2 samples to the mice burden swimming time
The walking weight load of each group mouse of table 3
| Dosage group (mg/kg BW) | Number of animals (only) | Walking weight load (min) | P values |
| 800 | 10 | 12.51±1.85 | 0.007 |
| 400 | 10 | 12.07±1.58 | 0.026 |
| 200 | 10 | 11.49±2.36 | 0.125 |
| Negative control | 10 | 9.81±0.97 | -- |
As seen from Table 3, heavy burden (5%) swimming time of each dosage group mouse of sample is than the extension of negative control group, and
The difference of high, middle dose group and negative control group has conspicuousness (P respectively<0.01 and P<0.05), show that the sample has to prolong
The effect of the walking weight load of long mouse.
Influence of 2.3 samples to the hepatic glycogen content of mouse
The each group mouse hepatic glycogen content measurement result of table 4
| Dosage group (mg/kg BW) | Number of animals (only) | Hepatic glycogen (mg/100g hepatic tissues) | P values |
| 800 | 10 | 2253.8±397.3 | 0.024 |
| 400 | 10 | 1980.7±359.3 | 0.504 |
| 200 | 10 | 1986.9±416.8 | 0.481 |
| Negative control | 10 | 1775.0±284.8 | -- |
Table 4 is visible, and the hepatic glycogen content of each dosage group mouse of sample is above negative control group, high dose group therein with
The difference of negative control group has conspicuousness (P<0.05), show that the sample has the function that the liver glycogen reserves for increasing mouse.
Influence of 2.4 samples to the blood lactase acid value after mouse movement
Blood lactase acid (mg/L) TG-AUC after each group mouse movement of table 5
As seen from Table 5,3 time point blood lactase acid TG-AUCs of each dosage of sample are respectively less than negative control group, wherein
High dose group and the difference of negative control group there is conspicuousness (P<0.05), show that the sample has and significantly reduce mouse movement
The effect of blood lactase acid TG-AUC afterwards.3 brief summaries
Respectively with 200,400, the embodiment 4 of 800mg/kg BW (be respectively equivalent to human body recommended amounts 5,10,20 times) dosage
The capsule of preparation can extend the walking weight load of mouse, increase the hepatic glycogen of tired mouse to mouse continuous gavage 30 days
Lay in, the blood lactase acid TG-AUC after reduction mouse movement, the generation of serum urea after the body weight increase and motion to mouse
Have no significant effect, prompt the sample that there is function of physical fatigue alleviation.
Embodiment 6
50 chronic fatigue syndrome patients, man 40, female 10, max age 55 years old, minimal ages 28 years old, average year
43.9 years old age, the course of disease 6 months to 2 years.
Diagnostic criteria：Lassitude, fatigue and weak, absent minded, failure of memory is slow in reacting, insomnia and dreamful sleep,
Disease-resistant and immunity degradation, agitation, palpitaition, dizziness, strongly fragrant disease.
Treatment method：Capsule of the present invention prepared by oral embodiment 4, twice daily, 1 tablet each time, continuously takes 3
Month.
Curative effect determinate standard：Cure, clinical symptoms disappear substantially；Effective, cardinal symptom eliminates；It is invalid, with nothing before treatment
Significant change.
As a result：
Therapeutic effect of 6 medicine of the present invention of table to chronic fatigue syndrome
| Sum | Cure | It is effective | It is invalid | Total effective rate |
| 50 | 19 | 27 | 4 | 92% |
Clinical case shows that medicine of the present invention has the effect of obvious for chronic fatigue syndrome.
Claims (8)
- A kind of 1. antifatigue health preparation of Chinese medicine, it is characterised in that：It is prepared by the bulk drug of following parts by weight：Red ginseng 1- 15th, maca 10-50, Radix Astragali 10-50, Radix Angelicae Sinensis 5-30, dried orange peel 1-15, green-tea extract 1-15.
- 2. the antifatigue health preparation of Chinese medicine as claimed in claim 1, it is characterised in that：Prepared by the bulk drug of following parts by weight Form：Red ginseng 5-10, maca 20-40, Radix Astragali 20-40, Radix Angelicae Sinensis 10-20, dried orange peel 5-10, green-tea extract 5-10.
- 3. the antifatigue health preparation of Chinese medicine as claimed in claim 1, it is characterised in that：Prepared by the bulk drug of following parts by weight Form：Red ginseng 5-8, maca 25-30, Radix Astragali 35-40, Radix Angelicae Sinensis 15-20, dried orange peel 8-10, green-tea extract 5-8.
- 4. the antifatigue health preparation of Chinese medicine as claimed in claim 1, it is characterised in that：Prepared by the bulk drug of following parts by weight Form：Red ginseng 5, maca 25, the Radix Astragali 40, Radix Angelicae Sinensis 15, dried orange peel 10, green-tea extract 5.
- 5. the antifatigue health preparation of Chinese medicine as described in claim any one of 1-4, it is characterised in that：Formulation is capsule, piece Agent.
- 6. a kind of preparation method of such as any one of claim 1-5 antifatigue health preparations of Chinese medicine, comprises the following steps：Red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine add 8-12 times to measure water boiling and extraction 2-4 times, each 1-3h；By extract solution Carry out being concentrated under reduced pressure into thick medicinal extract and be dried in vacuo and crushed 80 mesh sieves, obtain five kinds of Chinese medicine extraction powder；Extracted with green tea Thing is well mixed, and then prepares suitable formulation；Wherein, described green-tea extract preparation technology is：Water extraction under the conditions of 50-70 degree Take 1-3 times, each 1-3h, be concentrated under reduced pressure, sterilize, be spray-dried, crushed 80 mesh sieves and produce through flocculating, filtering.
- 7. the preparation method of the antifatigue health preparation of Chinese medicine as claimed in claim 6, comprises the following steps：Red ginseng, maca, the Radix Astragali, dried orange peel, Radix Angelicae Sinensis five kinds of Chinese medicine add 10 times to measure water boiling and extraction 3 times, each 1.5h；Extract solution is carried out It is concentrated under reduced pressure into thick medicinal extract and is dried in vacuo and crushed 80 mesh sieves, obtains five kinds of Chinese medicine extraction powder；Mixed with green-tea extract Close uniformly, then prepare suitable formulation；Wherein, described green-tea extract preparation technology is：Water extracts 2 times under the conditions of 60 degree, Each 2h, it is concentrated under reduced pressure, sterilizes, is spray-dried, crushed 80 mesh sieves and produce through flocculating, filtering.
- 8. the antifatigue health preparation of Chinese medicine as described in claim any one of 1-5 is preparing the medicine for the treatment of chronic fatigue syndrome Application in thing.
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| CN104187628A (en) * | 2014-08-12 | 2014-12-10 | 安徽阳光药业有限公司 | Cordyceps militaris and maca tablets and preparation method thereof |
| CN104397709A (en) * | 2014-12-12 | 2015-03-11 | 香格里拉县天丽斯生物科技发展有限公司 | Anti-fatigue composition |
| CN104586926A (en) * | 2014-12-12 | 2015-05-06 | 香格里拉县天丽斯生物科技发展有限公司 | Composition for restoring physical power and resisting fatigue |
| CN104872649A (en) * | 2015-04-27 | 2015-09-02 | 广州市炜鑫生物科技有限公司 | Medical and edible homologous maca food and preparation method thereof |
| CN106690288A (en) * | 2015-11-18 | 2017-05-24 | 珠海宝德润生健康科技有限公司 | Composition having functions of enhancing immunity and relieving physical fatigue and preparation method of composition |
| CN105943596A (en) * | 2016-06-01 | 2016-09-21 | 谢晓亮 | Composite containing maca and improving immunity and preparation method and application thereof |
| CN108576538A (en) * | 2018-06-12 | 2018-09-28 | 汪华东 | A kind of antifatigue crocodile composite and preparation method thereof that can refresh oneself |
| CN112704709B (en) * | 2021-01-25 | 2022-08-09 | 江南大学 | Traditional Chinese medicine composition for improving oxidative stress of muscle cells and application thereof |
| CN112791166B (en) * | 2021-01-25 | 2022-08-09 | 江南大学 | Medicinal and edible composition for enhancing muscle performance and relieving exercise-induced fatigue |
| CN113768004A (en) * | 2021-08-18 | 2021-12-10 | 福鼎市三余茶业有限公司 | White tea seasoning tea containing dried orange peel and preparation method thereof |
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