CN104223086A - Composite dendrobium huoshanense lozenge and preparation method thereof - Google Patents
Composite dendrobium huoshanense lozenge and preparation method thereof Download PDFInfo
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- CN104223086A CN104223086A CN201410514544.XA CN201410514544A CN104223086A CN 104223086 A CN104223086 A CN 104223086A CN 201410514544 A CN201410514544 A CN 201410514544A CN 104223086 A CN104223086 A CN 104223086A
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- medicinal powder
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- lozenge
- dendrobium huoshanense
- extract
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- 241001678082 Dendrobium huoshanense Species 0.000 title claims abstract description 20
- 239000007937 lozenge Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000002131 composite material Substances 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 87
- 239000000463 material Substances 0.000 claims abstract description 46
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 19
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940041616 menthol Drugs 0.000 claims abstract description 19
- 239000004376 Sucralose Substances 0.000 claims abstract description 16
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 16
- 235000019408 sucralose Nutrition 0.000 claims abstract description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 6
- 239000002245 particle Substances 0.000 claims description 36
- 235000009508 confectionery Nutrition 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000008187 granular material Substances 0.000 claims description 10
- 239000003826 tablet Substances 0.000 claims description 10
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 9
- 235000020985 whole grains Nutrition 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- -1 PVP pyrrolidones Chemical class 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract description 13
- 230000006870 function Effects 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 9
- 241000234435 Lilium Species 0.000 abstract description 6
- 210000004072 lung Anatomy 0.000 abstract description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 4
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 241001633680 Polygonatum odoratum Species 0.000 abstract description 2
- 210000001124 body fluid Anatomy 0.000 abstract description 2
- 239000010839 body fluid Substances 0.000 abstract description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 230000003750 conditioning effect Effects 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 16
- 229920003081 Povidone K 30 Polymers 0.000 description 11
- 239000000080 wetting agent Substances 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 8
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- 230000000694 effects Effects 0.000 description 6
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- 235000013402 health food Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 244000210789 Lilium lancifolium Species 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000008058 Lilium brownii Species 0.000 description 1
- 235000015982 Lilium brownii Nutrition 0.000 description 1
- 235000002156 Lilium lancifolium Nutrition 0.000 description 1
- 241001634090 Lilium pumilum Species 0.000 description 1
- 241001359444 Lilium tenuifolium Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241001474728 Satyrodes eurydice Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000010237 hybrid technique Methods 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
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- 230000033764 rhythmic process Effects 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composite dendrobium huoshanense lozenge which consists of medicine powder and auxiliary materials, wherein the medicine powder comprises the following components in parts by mass: 11-23 parts of a dendrobium huoshanense extract, 17-23 parts of a polygonatum odoratum extract and 14-25 parts of a lily extract; the auxiliary materials comprise the following components: mannitol which accounts for 10-30% of the mass of the medicine powder, menthol which accounts for 1.7-2.1% of the mass of the medicine powder, povidone pyrrolidone K30 which accounts for 4.5-8.5% of the mass of the medicine powder, sucralose which accounts for 0.03-0.1% of the mass of the medicine powder, and magnesium stearate which accounts for 0.3-0.6% of the mass of the medicine powder. The composite dendrobium huoshanense lozenge disclosed by the invention has the function of improving the body immunity by conditioning the functions of the lung, the kidney, the spleen and the stomach, and can also recover internal body fluid and moisten the throat by utilizing the sweetness and the coldness of dendrobium huoshanense.
Description
Technical field
The present invention relates to a kind of compound dendrobium huoshanense lozenge and preparation method thereof, belong to the health food containing Dendrobidium huoshanness and preparing technical field thereof.
Background technology
Modern society is due to the increase of the quickening of rhythm of life, operating pressure, the increasing of social interaction, add that irrational diet and air-polluting stimulate, immunity of organisms all may be caused to decline, thus reduce the ability that human body resists disease, more likely cause throat illness, cause the disease such as dysphonia, throat discomfort, cause people to feel exhausted, high liver fire, resistance weaken, so that cause the generation of various uncomfortable chronic disease even, time serious, also can have influence on the normal working and learning of people.
And health food of the prior art only has the function of develop immunitypty usually, or only have the function of clearing, the consumer simultaneously needed develop immunitypty and function of moistening and cleaning throat often will take at least two kinds of products by purchase and could meet demands of individuals.Therefore, the health food having clearing and develop immunitypty function concurrently is a blank on market.
Summary of the invention
The present invention for the deficiency that prior art exists, provides a kind of compound dendrobium huoshanense lozenge, has the function of clearing and develop immunitypty simultaneously just.
For solving the problem, the technical solution used in the present invention is as follows:
A kind of compound dendrobium huoshanense lozenge, is made up of medicinal powder and auxiliary material,
Described medicinal powder comprises the component of following mass fraction: Dendrobidium huoshanness extract, 11 parts ~ 23 parts; Rhizoma Polygonati Odorati extract, 17 parts ~ 23 parts; Bulbus Lilii extract, 14 parts ~ 25 parts;
Described auxiliary material comprises the component of following content: sweet mellow wine, is 10% ~ 30% of described medicinal powder quality; Menthol is 1.7% ~ 2.1% of described medicinal powder quality; PVP pyrrolidones K30 is 4.5% ~ 8.5% of described medicinal powder quality; Sucralose is 0.03% ~ 0.1% of described medicinal powder quality; Dolomol is 0.3% ~ 0.6% of described medicinal powder quality.
Wherein, Dendrobidium huoshanness extract, Rhizoma Polygonati Odorati extract and Bulbus Lilii extract in medicinal powder component can be obtained by following manner:
Dendrobidium huoshanness extract: be the fresh or dry stem of orchid Dendrobidium huoshanness (Dendrobiun huoshanense C.Z.Tang et S.J.Cheng), and specify under meeting " Anhui Province's prepared slices of Chinese crude drugs concocted specification " (2005 editions) " Dendrobidium huoshanness " item, through extracting in water, concentrated, dry, pulverizing is obtained.
Rhizoma Polygonati Odorati extract: be the dry rhizome of liliaceous plant radix polygonati officinalis (Polygonatum odoratum (Mill.) Druce), and specify under meeting " Chinese Pharmacopoeia " (2010 editions) two " radix polygonati officinalis " items, through extracting in water, concentrated, dry, pulverizing is obtained.
Bulbus Lilii extract: be the dry meat scale leaf of liliaceous plant tiger lily (Lilium lancifolium Thunb.), lily (Lilium brownii F.E.Brown var.viridulum Baker) or Lilium tenuifolium (Lilium pumilum DC.), and specify under meeting " Chinese Pharmacopoeia " (2010 editions) " lily " item, through extracting in water, concentrated, dry, pulverizing is obtained.
Described auxiliary material should meet the following requirements:
Menthol should meet the requirement under " Chinese Pharmacopoeia " (2010 editions) " menthol " item.
Sweet mellow wine, PVP pyrrolidones K30, dolomol should meet the requirement under " Chinese Pharmacopoeia " (2010 editions) two " sweet mellow wine ", " PVP K30s ", " dolomol " item.
Sucralose should meet the regulation of national food safety standard GB25531.
As technique scheme further preferably, the content of described sweet mellow wine is 20% ~ 30% of described medicinal powder quality; The content of described menthol is 1.8% of described medicinal powder quality; The content of described Sucralose is 0.1% of described medicinal powder quality.
As technique scheme further preferably, the content of described PVP pyrrolidones K30 is 8.1% of described medicinal powder quality, i.e. 4.5 times of described Determination of menthol.
Another object of the present invention is the preparation method providing above-mentioned compound dendrobium huoshanense lozenge, and it comprises the steps:
Pulverize: rear mistake 120 mesh sieve pulverized respectively by medicinal powder and auxiliary material, guarantees material powders uniform color, foreign is mixed into, without stain;
Batching: take medicinal powder and auxiliary material according to proportioning;
Mixing, granulate: medicinal powder except for magnesium stearate and auxiliary material are fully uniformly mixed and make it even, add appropriate absolute ethyl alcohol, make it to reach hold agglomerating and one touch namely fall apart, 16 orders granulate;
Dry: the wet granular made to be put in drying equipment dry under 55 DEG C ~ 60 DEG C conditions, control moisture 3% ~ 5%;
Whole grain: dried particle is put in pelletizing machine and cross the whole grain of 14 mesh sieve;
Total mixed: the particle made fully is mixed with dolomol;
Compressing tablet: by mould punching film-making.
As technique scheme further preferably, in described mixing, granulation step, the mode that medicinal powder except for magnesium stearate and auxiliary material are fully uniformly mixed is placed in groove to mix machine mixing 15 minutes.
As technique scheme further preferably, in described tableting step, need the temperature in controlled working workshop to be 18 DEG C ~ 26 DEG C, humidity is 45% ~ 65%.
Compared with prior art, implementation result of the present invention is as follows in the present invention:
A kind of compound dendrobium huoshanense lozenge of the present invention, select there is the integration of drinking and medicinal herbs class of helping human righteousness's function or the material combination that can be used for health food, side in Dendrobidium huoshanness taste sweet, micro-salty, be slightly cold, nontoxic, return stomach, kidney channel; Lily taste is sweet, cold in nature, the thoughts of returning home, lung two warp; Radix polygonati officinalis nature and flavor are sweet flat, enter lung, stomach warp; By regulating the function of lung, kidney, taste, strengthening the inherent healthy tendency that human body resists outer heresy, making body keep qi and blood gentle, the stable state of yin and yang in equilibrium, to reach the effect strengthening immunity of organism, utilizes again the sweet cold of Dendrobidium huoshanness simultaneously, make the reflex of cloudy Tianjin, throat must moisten; Effect of the cough-relieving of lily Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, tonifying middle-Jiao and Qi; Radix polygonati officinalis nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst, and three is used in conjunction and reaches by cloudy Tianjin of nourishing the lung and kidney the object that profit supports throat.And in conjunction with modern medicine and nutrition to the achievement in research improving immunity of organisms and clearing, Dendrobidium huoshanness, lily, radix polygonati officinalis are all containing activity in vivo compositions such as water-soluble polysaccharides, by promoting that blood middle leukocytes quantity increases, promoting that mononuclear macrophage function strengthens, promoting that T cell quantity increases, lymphoblastic transformation, and without incompatibility between each raw material, act synergistically, safety clothes consumption is large, and health care is definite, suitable long-term edible.
Accompanying drawing explanation
Fig. 1 is the schematic flow sheet of a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention;
Fig. 2 is the rate of moisture absorption figure of particle in granule formation technology Selection experiment;
Fig. 3 is Particles at Critical relative humidity figure in granule formation technology Selection experiment.
Detailed description of the invention
Fig. 1 is the overall flow of a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention, and a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention comprises the following steps:
Pulverize: medicinal powder and auxiliary material are placed in after pulverizer is pulverized respectively and cross 120 mesh sieves, guarantee material powders uniform color, foreign is mixed into, without stain;
Batching: take medicinal powder and auxiliary material according to proportioning;
Mixing, granulate: medicinal powder except for magnesium stearate and auxiliary material are placed in groove mix machine mixing 15 minutes, be fully uniformly mixed and make it even, add appropriate absolute ethyl alcohol, make it to reach hold agglomerating and one touch namely fall apart, 16 orders granulate;
Dry: the wet granular made to be put in drying equipment dry under 55 DEG C ~ 60 DEG C conditions, control moisture 3% ~ 5%;
Whole grain: dried particle is put in pelletizing machine and cross the whole grain of 14 mesh sieve;
Total mixed: the particle made and dolomol to be placed in three-dimensional motion mixer and to mix 30 minutes, make it to mix;
Compressing tablet: select the mould of suitable types, first-class punch die cleaning-sterilizing, regulate loading and pressure, require that sheet weight, outward appearance etc. conform to quality requirements; In tableting processes, claim once sheet weight every 15 minutes, guarantee that tablet weight variation is within ± 5% scope, reconnoitre slice, thin piece outward appearance at any time; During compressing tablet, indoor temperature will control at 18 DEG C ~ 26 DEG C, and humidity will control 45% ~ 65%.
Below in conjunction with process parameter optimizing test, content of the present invention is described.
One, auxiliary material selection
The factors such as the mouthfeel of oral buccal tablet agent and dose have larger impact for the compliance being suitable for crowd, general conventional auxiliary material has sweet mellow wine, sucrose and xylitol etc., they both can play the effect of filler, also flavouring can be played, consider the influence factor of day dose, therefore the consumption drafting auxiliary material is no more than 50% of medicinal powder amount.
As medicinal powder after the mixing of Dendrobidium huoshanness extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts, sweet mellow wine, sucrose, xylitol is selected to be flavouring respectively, consumption is respectively 10% ~ 50% of medicinal powder, with appropriate absolute ethyl alcohol for wetting agent is granulated, compressing tablet after dry, the selection result is in table 1.
The screening test (one) of table 1 auxiliary material
Get other value in 11 parts ~ 23 parts when the Dendrobidium huoshanness extract in medicinal powder, when Rhizoma Polygonati Odorati extract gets other value in 17 parts ~ 23 parts, Bulbus Lilii extract gets other value in 14 parts ~ 25 parts, result of the test is consistent with upper table 1.
Because the astringent taste of medicinal substances extract cannot be covered, and product objective is suitable for containing hyperglycaemia person in crowd, sucrose application restriction, intends selection and adds Sweetener Sucralose and flavouring menthol is auxiliary reaches flavoring effect.
Sucralose is 0.15% according to the regulation interpolation upper limit of " food additives use standard " (GB 2760-2011), with appropriate absolute ethyl alcohol for wetting agent is granulated, and compressing tablet after dry.
As medicinal powder after the mixing of Dendrobidium huoshanness extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts, add auxiliary material according to the formula of following table 2, screening test the results are shown in Table 2.
The screening test (two) of table 2 auxiliary material
Get other value in 11 parts ~ 23 parts when the Dendrobidium huoshanness extract in medicinal powder, when Rhizoma Polygonati Odorati extract gets other value in 17 parts ~ 23 parts, Bulbus Lilii extract gets other value in 14 parts ~ 25 parts, result of the test is consistent with upper table 2.Above-mentioned test shows, adds the sweet mellow wine of medicinal powder amount 20% ~ 30%, the Sucralose of medicinal powder amount 0.10%, the menthol of medicinal powder amount 1.8%, products taste and preparation technology better.
Two, the selection of wetting agent
Using Dendrobidium huoshanness extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts as medicinal powder, using the menthol of the Sucralose of the sweet mellow wine of medicinal powder amount 20%, medicinal powder amount 0.10% and medicinal powder amount 1.8% as auxiliary material, the ethanol of variable concentrations is selected to make wetting agent, 16 orders are granulated, 55 DEG C of dryings, the whole grain of 14 mesh sieve, obtains particle.With particle qualification rate and on the impact of compressing tablet for deliberated index, select suitable wetting agent, result of the test is in table 3.
Table 3 wetting agent Selection experiment
Get other value in 11 parts ~ 23 parts when the Dendrobidium huoshanness extract in medicinal powder, Rhizoma Polygonati Odorati extract gets other value in 17 parts ~ 23 parts, Bulbus Lilii extract gets other value in 14 parts ~ 25 parts, get it filled when the sweet mellow wine in auxiliary material other value in powder amount 10% ~ 30%, menthol get it filled other value that other value in powder amount 1.7% ~ 2.1%, Sucralose get it filled in powder amount 0.03% ~ 0.10% time, result of the test is consistent with upper table 3.
From above-mentioned test, need to add certain adhesive in material, intend selecting PVP pyrrolidones K30(hereinafter referred to as PVP-K30), PVP-K30 is not only a kind of excellent adhesive, it also has chemical inertness, insensitive to acid, alkali, salt, namely it also can directly can apply with dry powder with the application of the ethanolic solution of various variable concentrations.Add PVP-K30 in this product and namely can play stabilizing agent as the crosslinking agent of menthol as adhesive simultaneously, PVP-K30 as the general use amount of crosslinking agent is 2 ~ 5 times that are crosslinked thing.
Using Dendrobidium huoshanness extract 20 grams, Rhizoma Polygonati Odorati extract 20 grams and Bulbus Lilii extract 20 grams as medicinal powder, using medicinal powder amount 30% that is 18 grams sweet mellow wine, the medicinal powder amount 0.10% i.e. Sucralose of 0.06 gram and the medicinal powder amount 1.8% i.e. menthol of 1.08 grams is as auxiliary material, the ethanol of different PVP-K30 use amounts and variable concentrations is selected to make wetting agent, 16 mesh sieves are granulated, dry particle, with particle qualification rate, mouthfeel and menthol stability and on the impact of compressing tablet for deliberated index, select suitable wetting agent and adhesive, selection result is in table 4.
The determination Selection experiment of table 4 adhesive use amount and wetting agent
From result of the test, add the PVP-K30 of 4.5 times (namely 4.86 grams) of peppermint brain volume, adopt anhydrous ethanol preparation particle, result of the test is better.Other value in 11 grams ~ 23 grams is got, when Rhizoma Polygonati Odorati extract gets other value in 17 grams ~ 23 grams, Bulbus Lilii extract gets other value in 14 grams ~ 25 grams when the Dendrobidium huoshanness extract in medicinal powder, similarly, when PVP-K30 use amount is 4.5 times of peppermint brain volume, result of the test is better.
Three, hybrid parameter is selected
Using Dendrobidium huoshanness extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts as medicinal powder, do with the menthol of the Sucralose of the sweet mellow wine of medicinal powder amount 20%, medicinal powder amount 0.10%, medicinal powder amount 1.8% and the PVP-K30 of medicinal powder amount 8.1% for auxiliary material, extract and auxiliary material are put groove to mix in machine and mix 15 minutes, observe material color, judge the homogeneous degree of mixing of materials, observe at regular intervals once.Respectively got 5 some samples at random 5 minutes, 10 minutes, 15 minute period, investigate the mixing of materials uniform time with mixed material color, Thick many candies content for index, result of the test is in table 5, table 6, table 7 and table 8.
Table 5 mixed material color is investigated
Table 65 minute period material Thick many candies Content inspect (g/100g)
10 minute period of table 7 material content investigates (g/100g)
15 minute period of table 8 material content investigates (g/100g)
Result of the test shows: in supplementary material hybrid technique process, and mix 15 minutes, supplementary material mixes, and content can reach uniformity, therefore selects incorporation time to be 15 minutes.
Get other value in 11 parts ~ 23 parts when the Dendrobidium huoshanness extract in medicinal powder, Rhizoma Polygonati Odorati extract gets other value in 17 parts ~ 23 parts, Bulbus Lilii extract gets other value in 14 parts ~ 25 parts, get it filled when the sweet mellow wine in auxiliary material other value in powder amount 10% ~ 30%, menthol get it filled other value in powder amount 1.7% ~ 2.1%, Sucralose get it filled other value that other value in powder amount 0.03% ~ 0.10%, PVP-K30 get it filled in powder amount 4.5% ~ 8.5% time, need mixing that supplementary material within 15 minutes, just can be made to mix equally.
Four, granule formation technology is selected
With Dendrobidium huoshanness extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts are as medicinal powder, with the sweet mellow wine of medicinal powder amount 20%, the Sucralose of medicinal powder amount 0.10%, the menthol of medicinal powder amount 1.8% is done and the PVP-K30 of medicinal powder amount 8.1% is auxiliary material, selection adds absolute ethyl alcohol and crosses 16 orders granulations, 55 DEG C ~ 60 DEG C dryings, pellet moisture is 3% ~ 5%, the whole grain of 14 order, add that dolomol is always mixed obtained the dry particle of intermediate products after 30 minutes, with the mobility of particle of made particle, particle Moisture percentage, critical relative moisture (CRH) is index investigation granule formation technology.
(1) mobility of particle
Angle of repose measures: adopt fixed funnel method, 3 funnels are connected and is fixed on the At The Height of 3cm on the graph paper of horizontal positioned, carefully particle is poured into by hopper walls in the funnel gone up most until the particle cone tips that graph paper is formed touches funnel, surveyed the diameter (2R) of conical base by graph paper, calculate angle of repose (tg α=H/R).
Table 9 angle of repose measurement result
Result shows: the average angle of repose of particle is 31.45 °, shows that the mobility of this particle is better.
(2) particle Moisture percentage
Glass desicator bottom being contained sodium chloride supersaturated solution puts into the constant incubator constant weight 24 hours of 25 DEG C, and the relative humidity now in drier is 75 DEG C.By the particle drying for preparing to constant weight, bottom the measuring cup of constant weight, put into the particle of thick about 2 millimeters, in 25 DEG C of preservations, regularly (6,12,24,48,72 hours) weigh to put into above-mentioned glass desicator (weighing bottle cap to open), be calculated as follows hydroscopicity, result of the test is in table 10.Take Moisture percentage as ordinate, the time (h) is abscissa mapping, and the rate of moisture absorption figure of particle is shown in Figure of description 2.
Table 10 particle Moisture percentage
Result shows: the Moisture percentage prolongation in time of particle is not proportional increase, and Moisture percentage tends towards stability gradually.
(3) Particles at Critical relative humidity (CRH)
By the particle drying for preparing to constant weight, the particle of thick about 2 millimeters is put into bottom the measuring cup of constant weight, be placed in respectively after precise in the drier of the supersaturated solution filling 7 kinds of variable concentrations sulfuric acid and different salt and (weigh bottle cap to open), keep weighing after 7 days in 25 DEG C of constant incubators, calculate Moisture percentage, the results are shown in Table 11.With Moisture percentage (%) for ordinate, relative humidity (RH%) is abscissa mapping, and Particles at Critical relative humidity figure is shown in Figure of description 3.
Table 11 particle Moisture percentage
The abscissa that the point of intersection of tangents at curve two ends is corresponding is critical relative moisture.The critical relative moisture (CRH) of this particle 25 DEG C time is about 57%, large produce in packing particle time, can with reference to this value by the humid control in workshop below 57%, affect quality to avoid moisture absorption to make the water content of product too high.
Get other value in 11 parts ~ 23 parts when the Dendrobidium huoshanness extract in medicinal powder, Rhizoma Polygonati Odorati extract gets other value in 17 parts ~ 23 parts, Bulbus Lilii extract gets other value in 14 parts ~ 25 parts, get it filled when the sweet mellow wine in auxiliary material other value in powder amount 10% ~ 30%, menthol get it filled other value in powder amount 1.7% ~ 2.1%, Sucralose get it filled other value that other value in powder amount 0.03% ~ 0.10%, PVP-K30 get it filled in powder amount 4.5% ~ 8.5% time, Particles at Critical relative humidity (CRH) is 45% ~ 65%.
Five, conclusion
Can determine according to above-mentioned technical study data, production technology be supplementary material through pulverizing 120 mesh sieves, mixing, makes wetting agent with appropriate absolute ethyl alcohol, and 16 orders are granulated, 55 DEG C ~ 60 DEG C dryings, the whole grain of 14 order, adds dolomol always mixed 30 minutes, compressing tablet.Auxiliary material uses rationally, and preparation process operation feasible, product is through qualitative and quantitative analysis, and result all meets the requirements, and this formula and processing technology can play raw material efficacy effect.
Above content is detailed description made for the present invention in conjunction with specific embodiments, can not assert that the present invention specifically implements to be only limitted to these explanations.For those skilled in the art, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to the scope of protection of the invention.
Claims (6)
1. a compound dendrobium huoshanense lozenge, is characterized in that, is made up of medicinal powder and auxiliary material,
Described medicinal powder comprises the component of following mass fraction: Dendrobidium huoshanness extract, 11 parts ~ 23 parts; Rhizoma Polygonati Odorati extract, 17 parts ~ 23 parts; Bulbus Lilii extract, 14 parts ~ 25 parts;
Described auxiliary material comprises the component of following content: sweet mellow wine, is 10% ~ 30% of described medicinal powder quality; Menthol is 1.7% ~ 2.1% of described medicinal powder quality; PVP pyrrolidones K30 is 4.5% ~ 8.5% of described medicinal powder quality; Sucralose is 0.03% ~ 0.1% of described medicinal powder quality; Dolomol is 0.3% ~ 0.6% of described medicinal powder quality.
2. a kind of compound dendrobium huoshanense lozenge as claimed in claim 1, is characterized in that, the content of described sweet mellow wine is 20% ~ 30% of described medicinal powder quality; The content of described menthol is 1.8% of described medicinal powder quality; The content of described Sucralose is 0.1% of described medicinal powder quality.
3. a kind of compound dendrobium huoshanense lozenge as claimed in claim 2, is characterized in that, the content of described PVP pyrrolidones K30 is 8.1% of described medicinal powder quality.
4. the preparation method of a kind of compound dendrobium huoshanense lozenge as claimed in claim 1, is characterized in that, comprise the steps:
Pulverize: rear mistake 120 mesh sieve pulverized respectively by medicinal powder and auxiliary material, guarantees material powders uniform color, foreign is mixed into, without stain;
Batching: take medicinal powder and auxiliary material according to proportioning;
Mixing, granulate: medicinal powder except for magnesium stearate and auxiliary material are fully uniformly mixed and make it even, add appropriate absolute ethyl alcohol, make it to reach hold agglomerating and one touch namely fall apart, 16 orders granulate;
Dry: the wet granular made to be put in drying equipment dry under 55 DEG C ~ 60 DEG C conditions, control moisture 3% ~ 5%;
Whole grain: dried particle is put in pelletizing machine and cross the whole grain of 14 mesh sieve;
Total mixed: the particle made fully is mixed with dolomol;
Compressing tablet: by mould punching film-making.
5. a kind of compound dendrobium huoshanense lozenge as claimed in claim 4, is characterized in that, in described mixing, granulation step, the mode that medicinal powder except for magnesium stearate and auxiliary material are fully uniformly mixed is placed in groove to mix machine mixing 15 minutes.
6. a kind of compound dendrobium huoshanense lozenge as claimed in claim 4, is characterized in that, in described tableting step, need the temperature in controlled working workshop to be 18 DEG C ~ 26 DEG C, humidity is 45% ~ 65%.
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