CN104432063B - Composition for alleviating athletic fatigue and preparation method thereof - Google Patents
Composition for alleviating athletic fatigue and preparation method thereof Download PDFInfo
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- CN104432063B CN104432063B CN201410797522.9A CN201410797522A CN104432063B CN 104432063 B CN104432063 B CN 104432063B CN 201410797522 A CN201410797522 A CN 201410797522A CN 104432063 B CN104432063 B CN 104432063B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a composition for alleviating athletic fatigue and a preparation method thereof. The composition comprises the following components in parts by weight: 100-700 parts of a pine bark extract and 40-400 parts of theanine. Tests verify that the pine bark extract and theanine are used together, so that the sports level can be improved to a relatively great extent and the athletic fatigue can be alleviated or eliminated. According to the composition provided by the invention, the reasonable proportion of the pine bark extract and theanine is given, so that the composition has a synergistic effect, and the effect of alleviating or eliminating the athletic fatigue is maximized, thereby improving the sports athletic ability. Moreover, the preparation method is simple and auxiliary materials are reasonably applied, so that the effect of the extract can be utilized and given to play to the greatest extent. The composition provided by the invention is low in cost, the process satisfies the production specification of preparations, and the prepared preparation is easy to take, thereby facilitating adsorption by a human body and generally facilitating industrial popularization and application. The composition has a huge economic benefit.
Description
Technical field
The invention belongs to field of health care food, it is related to a kind of compositionss alleviating sports fatigue and its preparation.
Background technology
Sports fatigue refers to that its function can not be maintained at a certain specified level and/or can not remain a certain predetermined by body
Exercise intensity.During athlete carries out training, when training strength and training burden are constantly close to human body limit water
At ordinary times, body just easily produces fatigue.For normal population, sports fatigue is that the body ability to work that motion itself causes is temporary
When reduce, so long as not fatigue, through suitable rest and adjustment, body can return to normal condition, not
Insulting health.But the crowd often training being participated in for athlete or soldier etc. or carrying out intensive work
Say, the front fatigue once producing also does not have enough time to eliminate, and new fatigue creates.Body is chronically at fatigue state, tired
Labor will be accumulated by, and long will produce fatigue, the function of impact body and respond.If when body produces fatigue
After can take some measures, timely allaying tiredness, so that body each side is restored quickly, meaning is just very great.
Lactic acid is in human body strenuous exercise, and oxygen supply is not enough, and sugar generates through series reaction, is that glycolysiss supply
The final product of energy.Blood lactase acid is that in skeletal muscle, glycogen produces through glycolysiss energy supply.It is tired that the accumulation of lactic acid makes human body produce
Labor, leads to motor capacity to decline.Bulk deposition can suppress the normal activity of myoneural to lactic acid in vivo, and muscle can occur quickly
Fatigue.
Existing market is commonly used in the health product alleviating motion, and products material composition is more single, and excessively emphasizes
The curative effect of product, and ignore the absorption of human body with food-safety problem it is impossible to fully meet the demand of various people.And some
Plant component, has the effect improving cardiorespiratory Endurance, reducing blood lactase acid after motion, can effectively alleviate exercise fatigue.Therefore, therefrom
Medicine angle provides a kind of multi-faceted anti-Fatigue Composition to have practical significance.At present, there is not yet Cortex Pini Massonianae extract and tea
Propylhomoserin both active component share, and are used in the relevant report alleviating sports fatigue aspect.
Content of the invention
The first object of the present invention provides a kind of compositionss alleviating sports fatigue, effectively alleviates sports fatigue.
The compositionss alleviating sports fatigue of the present invention, including the following each component of weight portion: Cortex Pini Massonianae extract
100～700 parts, 40～400 parts of theanine.
Preferably, described compositionss include the following each component of weight portion: 300～700 parts of Cortex Pini Massonianae extract, theanine
40～200 parts.
In above-mentioned composition,
Weight portion of the present invention can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
It is not less than 85% procyanidin oligomer containing weight/mass percentage composition in heretofore described Cortex Pini Massonianae extract.
Specifically, the procyanidin oligomer being 95% containing weight/mass percentage composition in described Cortex Pini Massonianae extract.
The Main Ingredients and Appearance of Cortex Pini Massonianae extract is procyanidin, and its purity is higher, and the alleviation compounding the compositionss being formed is tired
The effect of labor is more obvious.
Cortex Pini Massonianae extract of the present invention can adopt commercially available product, or is obtained through conventional extracting method, in order that this
The effect of the compositionss of invention more preferably, is more beneficial for fatigue alleviating.Cortex Pini Massonianae extract of the present invention preferably passes through with lower section
Method is obtained: weighs the Cortex Pini of pulverizing, adds 95% (v/v) ethanol of 1～3 times amount, reflux, extract, 3～5h, Extracting temperature is
65～75 DEG C, filtered while hot, extract 3 times altogether, merging filtrate, by filtrate decompression recycling design and dry, obtain brown pinaster corium farinosum
End.It is highly preferred that the quantity of solvent of 3 extractions is respectively 2 times, 1 times, 1 times；Extraction time is more preferably 4h；Extracting temperature is more excellent
Elect 70 DEG C as.
In the above-mentioned extracting method of the present invention, the amount of the Extraction solvent being related to is based on the mass volume ratio of medical material and solvent
Calculate, unit can be g/ml.
Theanine of the present invention is the natural theanine extracting in Folium Camelliae sinensis, can adopt commercially available product, or through conventional extraction
Separation method is obtained.
In order that the effect of the compositionss of the present invention is more preferably, theanine of the present invention also can be obtained by the following method:
Folium Camelliae sinensis are inserted in the deionized water of its volume 7～9 times amount, 50～70 DEG C of extractions, extraction time is 1～3h, filters after extraction,
Extract 3 times altogether, merging filtrate, filtrate is passed through ion exchange resin, after remove impurity, uses 1.5mol/l nh3·h2O absorb-elute obtains
Theanine.It is highly preferred that the quantity of solvent of 3 extractions is 8 times, more preferably 60 DEG C of Extracting temperature；Extraction time is more preferably
2h.
Another object of the present invention is the preparation providing containing above-mentioned composition, and described preparation includes described compositionss and pharmacy
Upper acceptable carrier or diluent.
Described pharmaceutically acceptable carrier or diluent are selected from xylitol, Sorbitol, hydroxyl isomaltulose, Isomalt
In ketose, Mannitol, ethanol, Microcrystalline Cellulose, Lactose, hydroxypropyl methylcellulose, soybean oil, white sugar or magnesium stearate one
Plant or multiple.
Preparation of the present invention, can be prepared into solid preparation.
Wherein, described solid preparation is preferably tablet, powder or capsule.
Further, described capsule is specially hard capsule.
Preparation containing the compositionss alleviating sports fatigue of the present invention, described preparation is capsule, including weight portion
Following each component: 300～700 parts of Cortex Pini Massonianae extract, 40～400 parts of theanine, 200～650 parts of starch.
Preferably, described preparation is capsule, including the following each component of weight portion: 700 parts of Cortex Pini Massonianae extract, tea ammonia
Sour 100 parts, 200 parts of starch.
The present invention also provides described compositionss or described preparation to alleviate the application in the health product of sports fatigue in preparation.
The beneficial effect of compositionss of the present invention is:
1st, polyphenols are contained in Cortex Pini Massonianae extract, its main active is the low-molecular-weight polymeric of procyanidin
Body, is consumable products, also has other more than 40 kind water soluble ingredients, wherein most is organic acid, including caffeic acid, former youngster simultaneously
Boheic acid, vanillic acid, ferulic acid, gallic acid etc., and glucose lipid and other bioactive ingredients useful to human body.It has
There is strong anti-oxidation, have preferable scavenging action to hydroxy radical, ultra-oxygen anion free radical, lipid peroxidation is had preferably
Inhibitory action.Its Scavenging activity is 20 times of vitamin c, 50 times of vitamin e.
2nd, theanine is a kind of distinctive aminoacid of Folium Camelliae sinensis, belongs to amides compound, structure is similar to glutamic acid.Grind
Study carefully and show, theanine has blood pressure lowering, antitumor, mitigates depressed, raising learning and memory ability, the body fat that mitigates, raising body
Immunity etc. acts on.It has been shown that theanine can reduce hepatic glycogen consumption after mice swimming exercise, reduce blood urea nitrogen and blood
Lactate level, improves Burden-Swimming Ability of KM.
3rd, the present invention confirms through overtesting: Cortex Pini Massonianae extract and theanine share, and significantly can improve sports level,
Alleviate or eliminate Fatique after Sports；The present invention provides both rational proportionings, has synergistic function so that alleviating or eliminating
The effect of sports fatigue maximizes, and is conducive to improving agonistic sportses ability.And, preparation method is simple, adjuvant uses rationally,
Can farthest utilize and play the effect of extract.
4th, low cost of the present invention, technique meets the production specification of preparation, and the dosage form (especially capsule) of preparation is easily taken, and has
Benefit the absorption of human body, be totally beneficial to the promotion and application in industry, there is huge economic benefit.
Specific embodiment
Following examples are used for the present invention is described, but are not limited to the scope of the present invention.If not specializing, embodiment
In the conventional meanses that are well known to those skilled in the art of technological means used, raw materials used be commercial goods.
Buying producer for Cortex Pini Massonianae extract, theanine is realizability in order to further illustrate the present invention, but
It is to should not be taken to limit the scope of the present invention.
Raw material of the present invention: Cortex Pini Massonianae extract is purchased from the gloomy not biological company limited in Shaanxi, is 95% containing weight/mass percentage composition
Procyanidin oligomer；Theanine is purchased from Shanghai wheat bin science and technology biology company limited.The raw material bought can also be that other are normal
The product of rule specification, the specification effect being limited with the present invention is more preferable.
Cortex Pini Massonianae extract described in the embodiment of the present invention can be obtained by the following method: weigh the Cortex Pini of pulverizing, point
Not Jia Ru 2 times, 1 times, 1 times 95% (v/v) ethanol extraction 3 times, reflux, extract, is 4h, and Extracting temperature is 70 DEG C, while hot
Filter, merging filtrate, by filtrate decompression recycling design and dry, obtain brown Cortex Pini powder, standby；
Theanine described in the embodiment of the present invention can be obtained by the following method: Folium Camelliae sinensis going with its volume 8 times amount respectively
Ionized water 3 times, Extracting temperature is 60 DEG C, and extraction time is 2h, filters, merging filtrate, filtrate is passed through after extraction
Ion exchange resin adsorbs, and uses 1.5mol/l nh after remove impurity3·h2O eluting obtains theanine, standby.
The all simply optimum scheme of the extracting method of above-mentioned Cortex Pini Massonianae extract and theanine, in the specific implementation, each step
Rapid technological parameter as needed, can be according to the preferred version of Cortex Pini Massonianae extract in content of the invention and the extracting method of theanine
It is adjusted.
Embodiment 1: capsule
1st, the present embodiment prescription: Cortex Pini Massonianae extract 300g, theanine 50g, starch 650g, prepare 2000,0.5g/
Grain.
2nd, preparation method:
1) weigh Cortex Pini Massonianae extract, theanine, starch according to formula, cross 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, pour in capsule filling mould, fill capsule, polishing,
Subpackage.
3rd, specification: 150mg containing Cortex Pini Massonianae extract, theanine 25mg in every capsule.
4th, taking dose: oral 2 times daily, 3 every time.
Embodiment 2: powder
1st, the present embodiment prescription: Cortex Pini Massonianae extract 200g, theanine 60g, white sugar 1200g, isomaltulose 540g,
Microcrystalline Cellulose 1500g, magnesium stearate 500g, prepare 400 bags, 10g/ bag.
2nd, preparation method:
1) Cortex Pini Massonianae extract, theanine, white sugar, isomaltulose, Microcrystalline Cellulose and Hard Fat are weighed according to prescription
Sour magnesium, crosses 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, subpackage
3rd, specification: every bag of 500mg containing Cortex Pini Massonianae extract, theanine 150mg.
4th, instructions of taking: take 1 time daily, 1 bag every time.
Embodiment 3: tablet
1st, the present embodiment prescription: Cortex Pini Massonianae extract 100g, theanine 80g, Lactose 600g, Microcrystalline Cellulose 420g, system
Standby 1500,0.8g/ piece.
2nd, preparation method:
Above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, uses water as binding agent soft material；By above-mentioned soft material warp
Make granule in the oscillating granulator of 14 eye mesh screens, granule is inserted in multi-functional boiling drier, in 50 DEG C of airpillow-dry about
40 minutes, control pellet moisture 5%, always mix, tabletting, subpackage.
3rd, specification: every 66.7mg containing Cortex Pini Massonianae extract, theanine 53.3mg.
4th, taking dose: daily 2 times, each take 3.
Embodiment 4: capsule
1st, the present embodiment prescription: Cortex Pini Massonianae extract 1200g, theanine 400g, starch 400g, prepare 4000,0.5g/
Grain.
2nd, preparation method:
1) weigh Cortex Pini Massonianae extract, theanine, starch according to formula, cross 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, pour in capsule filling mould, fill capsule, polishing,
Subpackage.
3rd, specification: 300mg containing Cortex Pini Massonianae extract, theanine 100mg in every capsule.
4th, taking dose: oral 2 times daily, 3 every time.
Embodiment 5: capsule
1st, the present embodiment prescription: Cortex Pini Massonianae extract 1000g, theanine 600g, starch 400g, prepare 4000,0.5g/
Grain.
2nd, preparation method:
1) weigh Cortex Pini Massonianae extract, theanine, starch according to formula, cross 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, pour in capsule filling mould, fill capsule, polishing,
Subpackage.
3rd, specification: 250mg containing Cortex Pini Massonianae extract, theanine 150mg in every capsule.
4th, taking dose: oral 2 times daily, 3 every time.
Embodiment 6: capsule
1st, the present embodiment prescription: Cortex Pini Massonianae extract 700g, theanine 100g, starch 200g, prepare 2000,0.5g/
Grain.
2nd, preparation method:
1) weigh Cortex Pini Massonianae extract, theanine, starch according to formula, cross 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, pour in capsule filling mould, fill capsule, polishing,
Subpackage.
3rd, specification: 350mg containing Cortex Pini Massonianae extract, theanine 50mg in every capsule.
4th, taking dose: oral 2 times daily, 3 every time.
Embodiment 7: capsule
1st, the present embodiment prescription: Cortex Pini Massonianae extract 400g, theanine 400g, starch 200g, prepare 2000,0.5g/
Grain.
2nd, preparation method:
1) weigh Cortex Pini Massonianae extract, theanine, starch according to formula, cross 40 mesh sieves respectively, standby；
2) above-mentioned former, adjuvant is progressively increased method mix homogeneously by equivalent, pour in capsule filling mould, fill capsule, polishing,
Subpackage.
3rd, specification: 200mg containing Cortex Pini Massonianae extract, theanine 200mg in every capsule.
4th, taking dose: oral 2 times daily, 3 every time.
Experimental example 1: experiment on probation
1st, experimental subject
With 104 man long-distance runners of certain sport university (21.8 ± 0.75 years old mean age) as object of study.
2nd, experiment packet
Packet: 104 experimenters are randomly divided into 8 groups, and negative control group (n=13) takes placebo, 6/day；
Positive controls 1 take every capsule containing Cortex Pini Massonianae extract 400mg, and adjuvant is starch, 6/day；
Positive controls 2 take every capsule containing theanine 400mg, and adjuvant is starch, 6/day；
Positive controls 3 take the product of embodiment 4 in disclosed patent of invention cn103877263a, are containing Radix Ginseng Rubra, agate
Coffee, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, the capsule of green tea extract (theanine).Wherein, the weight ratio of each crude drug is: Radix Ginseng Rubra
20mg, Lepidinm meyenii Walp 100mg, Radix Astragali 160mg, Radix Angelicae Sinensis 60mg, Pericarpium Citri Reticulatae 40mg, green tea extract (theanine) 20mg, 6/day；
Experimental group 1 take the present invention antifatigue capsule agent (embodiment 4, in every capsule contain Cortex Pini Massonianae extract
300mg, theanine 100mg), 6/day；
Experimental group 2 take the present invention antifatigue capsule agent (embodiment 5, in every capsule contain Cortex Pini Massonianae extract
250mg, theanine 150mg), 6/day；
Experimental group 3 take the present invention antifatigue capsule agent (embodiment 6, in every capsule contain Cortex Pini Massonianae extract
350mg, theanine 50mg), 6/day；
Experimental group 4 take the present invention antifatigue capsule agent (embodiment 7, in every capsule contain Cortex Pini Massonianae extract
200mg, theanine 200mg), 6/day；
All continuously take 8 weeks.During whole experiment, prohibit and take other resisting fatigue food and medicine.
3rd, experimental technique
Require experimenter to come laboratory before the test on an empty stomach and take venous blood during peace and quiet, carry out before motion sports load (
Move on monark energy meter), first limber up 1min (0 load), then start to pedal with 50w power, be progressively incremented by negative
Lotus, reaches 70%hrmax (measured by trial test and draw) for 3 minutes about, is not hereafter further added by loading, continues 60 points to pedal
Clock.Centre of motion rate adopts polar table to monitor.The temperature of Control release room and humidity.Experimenter after taking 8 weeks nutriments,
Tested again.
4th, test index
Ear blood is taken within 3rd, 9,15 minutes to survey lactic acid after immediate postexercise, motion.Second day early morning extracting vein blood, measures serum
Superoxide dismutase (sod) vigor.
Method of testing: blood lactase acid adopts ysi 1500sport lactateanalyzer to measure, method is Enzyme Electrode；
Serum superoxide dismutaseses (sod) vigor adopts xanthine oxidase to measure, and determining instrument is 721 type spectrophotometrics
Meter.
5th, result statistics
Data processing adopts spss13.0 software, and all data are represented with means standard deviation, using variance and pairing t
The method of inspection.
6th, experimental result
The comparison of 6.1 blood lactate concentrations, is shown in Table 1.
Table 1: blood lactate concentration (mmol/l)
Compared with negative control group, #p < 0.05, ##p < 0.01；Compared with positive controls, * p < 0.05, * * p < 0.01；
Compared with experimental group 3, △ p ＜ 0.05, △ △ p ＜ 0.01.
Find out from table 1 result:
Immediate postexercise, positive controls 1,2,3 are substantially less than negative control group (p ＜ 0.05), the blood lactase acid of experimental group
Concentration all pole is substantially less than negative control group (p ＜ 0.01)；The blood lactate concentration of experimental group 3 is less than other experimental grouies.
Motion terminates rear 3min, and positive controls 1,2 blood lactase acid compared with negative control group is remarkably decreased (p ＜ 0.05),
Positive controls 3 pole compared with negative control group is remarkably decreased (p ＜ 0.01)；Experimental group is right with negative control group, the positive respectively
Compare according to group 1,2,3, its blood lactate concentration has different degrees of reduction (p ＜ 0.05, p ＜ 0.01)；Other each experimental grouies
Blood lactate concentration is significantly higher than experimental group 3 (p ＜ 0.05).
Motion terminates rear 9min, and each group blood lactase acid level has falling trend, positive controls and experimental group to be all substantially less than
Negative control group, there was no significant difference compared with positive controls for experimental group；
Motion terminates rear 15min, and each group all returns to level during peace and quiet.
Lactic acid is the product that in motor process, internal energy substance catabolism obtains, a large amount of acidic materials accumulation, leads to
Muscle, the swollen and metal fatigue of joint acid.Take experimental group sample, help speed up the removing speed of internal blood lactase acid, be conducive to
Extend exercise tolerance, improve motor capacity.By this research it is found that the proportioning of experimental group 3 with respect to other experimental grouies Lai
Say, remove the speed of blood lactase acid faster.
6.2 oxidation resistance test results
After experiment, m seq measures serum superoxide dismutaseses (sod) vigor of each group respectively, and experimental result is shown in Table
2.
Table 2: the impact to each group experimenter's oxidation resistance after experiment
Compared with negative control group, #p ＜ 0.05, ##p ＜ 0.01；Compared with positive controls, * p ＜ 0.05；With the previous day
Early morning is compared, △ p ＜ 0.05.
As shown in Table 2, the sod vigor in each group experimenter morning next day is all high compared with morning on the previous day, but positive controls and the moon
Property matched group compares that there was no significant difference, and experimental group is had compared with negative control group and different degrees of increases (p ＜ 0.05, p ＜
0.01), experimental group 3 m seq sod vigor is significantly higher than early morning head day (p ＜ 0.05), also significantly greater than positive controls time
Early morning day (p ＜ 0.05).
Motion causes body free radical to increase, and excessive free radical can lead to some important metabolic enzymes because of cross-linked polymeric
Inactivation, causes a series of pathological change, leads to the ability to work of human body to decline and produce feeling of fatigue.Therefore, accelerate free radical
Removing speed, improve anti-oxidative defense function, be favorably improved motor capacity, promote fatigue recovery, reduce peroxidation
Damage to body.Table 2 shows, the compositionss of the present invention can be effectively facilitated the rising of body sod vigor, enhances body and resists
The ability of free radical, the enhancing oxidation resistance of experimental group 3 is the strongest.
6.3rd, experiment conclusion
From the point of view of whole experiment process, the compositionss that the present invention provides have the effect of Synergistic, can make experimenter
Blood lactase acid resume speed is accelerated, and sod value vigor raises, and this is all advantageous for extending the key factor of exercise tolerance, is conducive to transporting
The raising of kinetic force.Motion can cause body free radical to increase, and excessive free radical can lead to some important metabolic enzymes because
Cross-linked polymeric and inactivate, cause a series of pathological change, lead to the ability to work of human body to decline and produce fatigue.Therefore, plus
The removing speed of fast free radical, improves anti-oxidative defense function, and to improving, motor capacity is significant.Oxidation resistance is surveyed
Examination test result indicate that, take the present composition can be effectively facilitated body sod raise, can effectively improve body resist from
By the ability of base, also have certain effect with promotion fatigue recovery to improving motor capacity.
Although, above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (9)
1. a kind of compositionss alleviating sports fatigue are it is characterised in that include the following each component of weight portion: Cortex Pini extracts
300～700 parts of thing, 100～200 parts of theanine；It is not less than 85% containing weight/mass percentage composition in described Cortex Pini Massonianae extract
Procyanidin oligomer.
2. compositionss according to claim 1 it is characterised in that: in described Cortex Pini Massonianae extract containing weight/mass percentage composition be
95% procyanidin oligomer.
3. compositionss according to claim 1 it is characterised in that: include the following each component of weight portion: Cortex Pini extracts
700 parts of thing, 100 parts of theanine.
4. the compositionss according to claim 1 or 2 or 3 it is characterised in that: described Cortex Pini Massonianae extract is by the following method
It is obtained: weigh the Cortex Pini of pulverizing, add in 95% ethanol of 1～3 times amount, reflux, extract, 3～5h, Extracting temperature is 65～75
DEG C, filtered while hot, extract 3 times altogether, merging filtrate, by filtrate decompression recycling design and dry, obtain brown Cortex Pini powder, i.e. institute
State Cortex Pini Massonianae extract.
5. contain claim 1 to 4 any one of compositionss preparation it is characterised in that: described preparation includes described group
Compound and pharmaceutically acceptable carrier or diluent.
6. preparation according to claim 5 it is characterised in that: described pharmaceutically acceptable carrier or diluent are selected from wood
Sugar alcohol, Sorbitol, hydroxyl isomaltulose, isomaltulose, Mannitol, ethanol, Microcrystalline Cellulose, Lactose, hydroxypropyl are fine
One or more of dimension element, soybean oil, white sugar or magnesium stearate.
7. preparation according to claim 5 it is characterised in that: described preparation is capsule, including following each of weight portion
Component: 300～700 parts of Cortex Pini Massonianae extract, 40～400 parts of theanine, 200～650 parts of starch.
8. preparation according to claim 7 it is characterised in that: described capsule includes the following each component of weight portion: pine
700 parts of bark extract, 100 parts of theanine, 200 parts of starch.
9. the compositionss any one of claim 1-4 or the preparation any one of claim 5-8 are slow in preparation
Application in the health product of solution sports fatigue.
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| EP3461260A4 (en) * | 2016-05-17 | 2020-02-12 | Alphagen NZ Limited | Compositions comprising l-theanine, proanthocyanidin/s and a catechin and uses thereof |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wei Bing Inventor after: Xu Yue Inventor before: Xu Yue |