CN104223086B - Composite dendrobium huoshanense lozenge and preparation method thereof - Google Patents

Composite dendrobium huoshanense lozenge and preparation method thereof Download PDF

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CN104223086B
CN104223086B CN201410514544.XA CN201410514544A CN104223086B CN 104223086 B CN104223086 B CN 104223086B CN 201410514544 A CN201410514544 A CN 201410514544A CN 104223086 B CN104223086 B CN 104223086B
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medicated powder
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adjuvant
extract
dendrobium huoshanense
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CN104223086A (en
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陈锋
李滨
郑海磊
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JIUXIANZUN HUOSHAN DENDROBIUM Co Ltd
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JIUXIANZUN HUOSHAN DENDROBIUM Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23PSHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00Shaping or working of foodstuffs characterised by the products
    • A23P10/20Agglomerating; Granulating; Tabletting
    • A23P10/28Tabletting; Making food bars by compression of a dry powdered mixture
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a composite dendrobium huoshanense lozenge which consists of medicine powder and auxiliary materials, wherein the medicine powder comprises the following components in parts by mass: 11-23 parts of a dendrobium huoshanense extract, 17-23 parts of a polygonatum odoratum extract and 14-25 parts of a lily extract; the auxiliary materials comprise the following components: mannitol which accounts for 10-30% of the mass of the medicine powder, menthol which accounts for 1.7-2.1% of the mass of the medicine powder, povidone pyrrolidone K30 which accounts for 4.5-8.5% of the mass of the medicine powder, sucralose which accounts for 0.03-0.1% of the mass of the medicine powder, and magnesium stearate which accounts for 0.3-0.6% of the mass of the medicine powder. The composite dendrobium huoshanense lozenge disclosed by the invention has the function of improving the body immunity by conditioning the functions of the lung, the kidney, the spleen and the stomach, and can also recover internal body fluid and moisten the throat by utilizing the sweetness and the coldness of dendrobium huoshanense.

Description

A kind of compound dendrobium huoshanense buccal tablet and preparation method thereof
Technical field
The present invention relates to a kind of compound dendrobium huoshanense buccal tablet and preparation method thereof, belong to the health food containing Herba Dendrobii and preparing technical field thereof.
Background technology
Modern society is due to the quickening of rhythm of life, the increase of operating pressure, the increasing of social communication, plus irrational diet and the stimulation of air pollution, immunity of organisms all may be caused to decline, thus reduce human body and resist the ability of disease, more likely cause throat illness, cause the disease such as dysphonia, throat discomfort, cause people to feel exhausted, high liver fire, resistance weaken, so that causing the generation of various uncomfortable even chronic disease, time serious, also affect the normal working and learning of people.
And health food of the prior art the most only has a function of enhancing immunity, or only having the function of moistening and cleaning throat, the consumer's purchase to be passed through simultaneously being required for enhancing immunity and function of moistening and cleaning throat is taken at least two product and could be met demands of individuals.Therefore, the health food having moistening and cleaning throat and enhancing immunity function concurrently is a blank on market.
Summary of the invention
The deficiency that the present invention exists for prior art just, it is provided that a kind of compound dendrobium huoshanense buccal tablet, has the function of moistening and cleaning throat and enhancing immunity simultaneously.
For solving the problems referred to above, the technical solution used in the present invention is as follows:
A kind of compound dendrobium huoshanense buccal tablet, is made up of medicated powder and adjuvant,
Described medicated powder includes the component of following mass fraction: Herba Dendrobii extract, 11 parts~23 parts;Rhizoma Polygonati Odorati extract, 17 parts~23 parts;Bulbus Lilii extract, 14 parts~25 parts;
Described adjuvant includes the component of following content: mannitol, for the 10%~30% of described medicated powder quality;Mentholum, for the 1.7%~2.1% of described medicated powder quality;Polyvidone ketopyrrolidine K30, for the 4.5%~8.5% of described medicated powder quality;Sucralose, for the 0.03%~0.1% of described medicated powder quality;Magnesium stearate, for the 0.3%~0.6% of described medicated powder quality.
Wherein, Herba Dendrobii extract, Rhizoma Polygonati Odorati extract and Bulbus Lilii extract in medicated powder component can be obtained by following manner:
Herba Dendrobii extract: for the fresh or dry stem of orchid Herba Dendrobii (Dendrobiun huoshanense C.Z.Tang et S.J.Cheng), and meet and specify under " Anhui Province's prepared slices of Chinese crude drugs concocted specification " (2005 editions) " Herba Dendrobii " item, through extracting in water, concentrate, be dried, pulverize prepared.
Rhizoma Polygonati Odorati extract: for the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati (Polygonatum odoratum (Mill.) Druce), and meet " Chinese Pharmacopoeia " (2010 editions) two " Rhizoma Polygonati Odorati " Lower regulation, through extracting in water, concentrate, be dried, pulverize prepared.
Bulbus Lilii extract: for liliaceous plant tiger lily (Lilium lancifolium Thunb.), Bulbus Lilii (Lilium brownii F.E.Brown var.viridulum Or the dry meat scale leaf of Lilium tenuifolium (Lilium pumilum DC.) Baker), and meet and specify under " Chinese Pharmacopoeia " (2010 editions) " Bulbus Lilii " item, through extracting in water, concentrate, be dried, pulverize prepared.
Described adjuvant should meet the following requirements:
Mentholum should meet the requirement under " Chinese Pharmacopoeia " (2010 editions) " Mentholum " item.
Mannitol, polyvidone ketopyrrolidine K30, magnesium stearate should meet the requirement under " Chinese Pharmacopoeia " (2010 editions) two " mannitol ", " PVP K30s ", " magnesium stearate " item.
Sucralose should meet the regulation of national food safety standard GB25531.
Further preferred as technique scheme, the content of described mannitol is the 20%~30% of described medicated powder quality;The content of described Mentholum is the 1.8% of described medicated powder quality;The content of described sucralose is the 0.1% of described medicated powder quality.
Further preferred as technique scheme, content is described medicated powder quality the 8.1% of described polyvidone ketopyrrolidine K30,4.5 times of the most described Determination of menthol.
Further object is that the preparation method providing above-mentioned compound dendrobium huoshanense buccal tablet, it comprises the steps:
Pulverize: medicated powder and adjuvant cross 120 mesh sieves after pulverizing respectively, it is ensured that material powders uniform color, foreign are mixed into, without stain;
Dispensing: weigh medicated powder and adjuvant according to proportioning;
Mixing, pelletize: medicated powder except for magnesium stearate and adjuvant are thoroughly mixed and are allowed to uniform, add appropriate dehydrated alcohol, make up to hold agglomerating and one touch the most scattered, 16 mesh pelletize;
It is dried: the wet granular made is put in drying equipment and be dried under the conditions of 55 DEG C~60 DEG C, controls moisture 3%~5%;
Granulate: dried granule is put and crosses 14 mesh sieve granulate in pelletizing machine;
Total mixed: the granule made and magnesium stearate are sufficiently mixed uniformly;
Tabletting: by mould punching film-making.
Further preferred as technique scheme, in described mixing, granulation step, the mode that medicated powder except for magnesium stearate and adjuvant are thoroughly mixed is placed in groove and mixes in machine and mix 15 minutes.
Further preferred as technique scheme, in described tableting step, needing the temperature controlling job shop is 18 DEG C~26 DEG C, and humidity is 45%~65%.
Compared with prior art, the implementation result of the present invention is as follows for the present invention:
A kind of compound dendrobium huoshanense buccal tablet of the present invention, selects to have the integration of edible and medicinal herbs class helping human righteousness's function or the material combination that can be used for health food, Herba Dendrobii sweet in the mouth in side, micro-salty, be slightly cold, nontoxic, return stomach, kidney channel;Bulbus Lilii sweet in the mouth, cold in nature, GUIXIN, lung two warp;Rhizoma Polygonati Odorati nature and flavor are sweet flat, enter lung, stomach warp;By regulation lung, kidney, the function of taste, strengthen human body and resist the inherent healthy energy of exopathogen, make body keep QI and blood gentle, the steady statue of YIN and YANG in a relative equilibrium, to reach the effect of enhancing human body immunity, utilizes again the sweet cold of Herba Dendrobii simultaneously, making cloudy Tianjin reflex, throat must moisten;Bulbus Lilii nourishing YIN and moistening the lung cough-relieving, clearing away heart-fire for tranquillization, effect of invigorating the spleen and replenishing QI;Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, three is used in conjunction the cloudy Tianjin by nourishing the lung and kidney and reaches to moisten the purpose of foster throat.And combine modern medicine and threpsology to improving immunity of organisms and the achievement in research of moistening and cleaning throat, Herba Dendrobii, Bulbus Lilii, Rhizoma Polygonati Odorati all contain the activity in vivo compositions such as water-soluble polysaccharides, can increase by promoting blood middle leukocytes quantity, promotion mononuclear phagocyte function strengthens, promotion T cell quantity increases, lymphoblastic transformation, and without incompatibility between each raw material, synergism is good, safety clothes consumption is big, and health care is definite, is suitably eaten for a long time.
Accompanying drawing explanation
Fig. 1 is the schematic flow sheet of a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention;
Fig. 2 is the rate of moisture absorption figure of granule in granule formation technology Selection experiment;
Fig. 3 is Particles at Critical relative humidity figure in granule formation technology Selection experiment.
Detailed description of the invention
Fig. 1 is the overall flow of a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention, and a kind of compound dendrobium huoshanense process for preparing buccal lozenge of the present invention comprises the following steps:
Pulverize: medicated powder and adjuvant are placed in pulverizer after pulverizing respectively and cross 120 mesh sieves, it is ensured that material powders uniform color, foreign are mixed into, without stain;
Dispensing: weigh medicated powder and adjuvant according to proportioning;
Mixing, pelletize: medicated powder except for magnesium stearate and adjuvant are placed in groove mix in machine mix 15 minutes, be thoroughly mixed and be allowed to uniform, add appropriate dehydrated alcohol, make up to hold agglomerating and one touch the most scattered, 16 mesh pelletize;
It is dried: the wet granular made is put in drying equipment and be dried under the conditions of 55 DEG C~60 DEG C, controls moisture 3%~5%;
Granulate: dried granule is put and crosses 14 mesh sieve granulate in pelletizing machine;
Total mixed: the granule made to be placed in three-dimensional motion mixer with magnesium stearate and mixes 30 minutes, be allowed to mix homogeneously;
Tabletting: select the mould of suitable types, first-class punch die cleaning-sterilizing, regulate loading and pressure, it is desirable to tablet weight, outward appearance etc. conform to quality requirements;In tableting processes, claimed a tablet weight every 15 minutes, it is ensured that tablet weight variation, within the scope of ± 5%, reconnoitres slice, thin piece outward appearance at any time;During tabletting, indoor temperature to control at 18 DEG C~26 DEG C, and humidity to control 45%~65%.
Below in conjunction with process parameter optimizing test, present disclosure is described.
One, adjuvant selection
The factors such as the mouthfeel of oral buccal tablet agent and dose have large effect for the compliance being suitable for crowd, general conventional adjuvant has mannitol, sucrose and xylitol etc., they both can play the effect of filler, also the effect of correctives can be played, in view of the influence factor of day dose, therefore draft the consumption of adjuvant no more than the 50% of medicated powder amount.
As medicated powder after mixing using Herba Dendrobii extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts, selecting mannitol, sucrose, xylitol respectively is correctives, consumption is respectively the 10%~50% of medicated powder, pelletize with appropriate dehydrated alcohol for wetting agent, dried tabletting, the selection result is shown in Table 1.
The screening test (one) of table 1 adjuvant
When other value during the Herba Dendrobii extract in medicated powder takes 11 parts~23 parts, Rhizoma Polygonati Odorati extract take other value in 17 parts~23 parts, Bulbus Lilii extract take other value in 14 parts~25 parts time, result of the test is consistent with upper table 1.
Because the astringent taste of medicinal substances extract cannot be covered, and product objective is suitable in crowd containing hyperglycemia person, and sucrose application limits, and intends selecting to add Sweetener Sucralose and correctives Mentholum auxiliary reaches taste masking effect.
It is 0.15% that sucralose adds the upper limit according to the regulation of " food additive use standard " (GB 2760-2011), pelletizes with appropriate dehydrated alcohol for wetting agent, dried tabletting.
As medicated powder after mixing using Herba Dendrobii extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts, adding adjuvant according to the formula of table 2 below, screening test the results are shown in Table 2.
The screening test (two) of table 2 adjuvant
When other value during the Herba Dendrobii extract in medicated powder takes 11 parts~23 parts, Rhizoma Polygonati Odorati extract take other value in 17 parts~23 parts, Bulbus Lilii extract take other value in 14 parts~25 parts time, result of the test is consistent with upper table 2.Above-mentioned test shows, adds the mannitol of medicated powder amount 20%~30%, the sucralose of medicated powder amount 0.10%, the Mentholum of medicated powder amount 1.8%, and products taste and preparation technology are preferable.
Two, the selection of wetting agent
Using Herba Dendrobii extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts as medicated powder, using the Mentholum of mannitol, the sucralose of medicated powder amount 0.10% and the medicated powder amount 1.8% of medicated powder amount 20% as adjuvant, wetting agent made by the ethanol selecting variable concentrations, 16 mesh are pelletized, 55 DEG C are dried, 14 mesh sieve granulate, obtain granule.With granule qualification rate and on the impact of tabletting as deliberated index, select suitable wetting agent, result of the test is shown in Table 3.
Table 3 wetting agent Selection experiment
Other value in the Herba Dendrobii extract in medicated powder takes 11 parts~23 parts, Rhizoma Polygonati Odorati extract take other value in 17 parts~23 parts, Bulbus Lilii extract takes other value in 14 parts~25 parts, when the mannitol in adjuvant get it filled other value in powder amount 10%~30%, Mentholum get it filled other value in powder amount 1.7%~2.1%, sucralose get it filled other value in powder amount 0.03%~0.10% time, result of the test is consistent with upper table 3.
From above-mentioned test, material needs add certain binding agent, intend selecting polyvidone ketopyrrolidine K30(hereinafter referred to as PVP-K30), PVP-K30 is not only a kind of excellent binding agent, it also has chemical inertness, insensitive to acid, alkali, salt, it i.e. can be applied with the ethanol solution of various variable concentrations can also be directly with dry powder application.Adding PVP-K30 in this product to may act as binding agent and play the effect of stabilizer simultaneously as the cross-linking agent of Mentholum, PVP-K30 is be crosslinked thing 2~5 times as the cross-linking agent amount of generally using.
Using Herba Dendrobii extract 20 grams, Rhizoma Polygonati Odorati extract 20 grams and Bulbus Lilii extract 20 grams as medicated powder, using the Mentholum of mannitol, the sucralose of medicated powder amount 0.10% that is 0.06 gram and medicated powder amount 1.8% that is 1.08 gram of medicated powder amount 30% that is 18 gram as adjuvant, wetting agent made by the ethanol selecting different PVP-K30 usage amounts and variable concentrations, 16 mesh sieves are pelletized, the granule being dried, with granule qualification rate, mouthfeel and Mentholum stability and on the impact of tabletting as deliberated index, select suitable wetting agent and binding agent, select to the results are shown in Table 4.
Table 4 binding agent usage amount and the determination Selection experiment of wetting agent
From result of the test, adding the PVP-K30 of 4.5 times (i.e. 4.86 grams) of Herba Menthae brain volume, use dehydrated alcohol to prepare granule, result of the test is preferable.When other value during the Herba Dendrobii extract in medicated powder takes 11 grams~23 grams, Rhizoma Polygonati Odorati extract take other value in 17 grams~23 grams, Bulbus Lilii extract take other value in 14 grams~25 grams time, similarly, when PVP-K30 usage amount is 4.5 times of Herba Menthae brain volume, result of the test is preferable.
Three, hybrid parameter selects
Using Herba Dendrobii extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts as medicated powder, make with the mannitol of medicated powder amount 20%, the sucralose of medicated powder amount 0.10%, the Mentholum of medicated powder amount 1.8% and the PVP-K30 of medicated powder amount 8.1% is as adjuvant, extract is put groove with adjuvant mix machine mixes 15 minutes, observe material color, judge material mixing uniform level, observe at regular intervals once.5 minutes, 10 minutes, 15 minute period each took 5 some samples at random, was the time that index investigates material mix homogeneously with mixed material color, crude polysaccharides content, result of the test is shown in Table 5, table 6, table 7 and table 8.
Table 5 mixed material color is investigated
65 minute period of table material crude polysaccharides content investigates (g/100g)
7 10 minute period material content of table investigates (g/100g)
8 15 minute period material content of table investigates (g/100g)
Result of the test shows: during supplementary material hybrid technique, mixes 15 minutes, supplementary material mix homogeneously, and content can reach uniformity, therefore selecting incorporation time is 15 minutes.
Other value in the Herba Dendrobii extract in medicated powder takes 11 parts~23 parts, Rhizoma Polygonati Odorati extract take other value in 17 parts~23 parts, Bulbus Lilii extract takes other value in 14 parts~25 parts, when the mannitol in adjuvant get it filled other value in powder amount 10%~30%, Mentholum get it filled other value in powder amount 1.7%~2.1%, sucralose get it filled other value in powder amount 0.03%~0.10%, PVP-K30 get it filled other value in powder amount 4.5%~8.5% time, need also exist for mixing 15 minutes and just can make supplementary material mix homogeneously.
Four, granule formation technology selects
With Herba Dendrobii extract 20 parts, Rhizoma Polygonati Odorati extract 20 parts and Bulbus Lilii extract 20 parts are as medicated powder, mannitol with medicated powder amount 20%, the sucralose of medicated powder amount 0.10%, the Mentholum of medicated powder amount 1.8% is made and the PVP-K30 of medicated powder amount 8.1% is adjuvant, select to add dehydrated alcohol and cross 16 mesh granulations, 55 DEG C~60 DEG C are dried, pellet moisture is 3%~5%, 14 mesh granulate, add after magnesium stearate always mixes 30 minutes and obtain the dry granule of intermediate products, mobility of particle with made granule, granule Moisture percentage, critical relative humidity (CRH) is that index investigates granule formation technology.
(1) mobility of particle
Angle of repose measures: use fixed funnel method, 3 funnels are connected and is fixed on the graph paper of horizontal positioned at the height of 3cm, carefully granule is poured in the funnel gone up most until the granule cone tips formed on graph paper touches funnel by hopper walls, surveyed the diameter (2R) of conical base by graph paper, calculate angle of repose (tg α=H/R).
Table 9 measurement result angle of repose
Result shows: the average angle of repose of granule is 31.45 °, shows that the mobility of this granule is preferable.
(2) granule Moisture percentage
Bottom being contained the glass desicator of sodium chloride supersaturated solution and puts into the constant incubator constant weight 24 hours of 25 DEG C, now the relative humidity in exsiccator is 75 DEG C.After the particle drying for preparing to constant weight, putting into the granule of thick about 2 millimeters bottom the weighing botle of constant weight, in 25 DEG C of preservations, regularly (6,12,24,48,72 hours) weigh to put into above-mentioned glass desicator (weighing bottle cap to open), being calculated as follows hydroscopicity, result of the test is shown in Table 10.With Moisture percentage as vertical coordinate, the time (h) is abscissa mapping, and the rate of moisture absorption figure of granule is shown in Figure of description 2.
Table 10 granule Moisture percentage
Result shows: the prolongation in time of the Moisture percentage of granule is not proportional increase, and Moisture percentage gradually tends towards stability.
(3) Particles at Critical relative humidity (CRH)
After the particle drying for preparing to constant weight, the granule of thick about 2 millimeters is put into bottom the weighing botle of constant weight, (weighing bottle cap to open) it is respectively placed in the exsiccator of the supersaturated solution filling 7 kinds of variable concentrations sulphuric acid and different salt after precise, weigh after keeping 7 days in 25 DEG C of constant incubators, calculate Moisture percentage, the results are shown in Table 11.With Moisture percentage (%) as vertical coordinate, relative humidity (RH%) is abscissa mapping, and Particles at Critical relative humidity figure is shown in Figure of description 3.
Table 11 Granule Moisture percentage
The abscissa that the point of intersection of tangents at curve two ends is corresponding is critical relative humidity.This granule critical relative humidity (CRH) when 25 DEG C is about 57%, big produce in subpackage granule time, refer to this value by the humid control in workshop below 57%, affect quality to avoid moisture absorption to make the water content of product too high.
Other value in the Herba Dendrobii extract in medicated powder takes 11 parts~23 parts, Rhizoma Polygonati Odorati extract take other value in 17 parts~23 parts, Bulbus Lilii extract takes other value in 14 parts~25 parts, when the mannitol in adjuvant get it filled other value in powder amount 10%~30%, Mentholum get it filled other value in powder amount 1.7%~2.1%, sucralose get it filled other value in powder amount 0.03%~0.10%, PVP-K30 get it filled other value in powder amount 4.5%~8.5% time, Particles at Critical relative humidity (CRH) is 45%~65%.
Five, conclusion
According to above-mentioned technical study data it was determined that production technology is supplementary material size-reduced mistake 120 mesh sieve, mixing, make wetting agent with appropriate dehydrated alcohol, 16 mesh are pelletized, and 55 DEG C~60 DEG C are dried, and 14 mesh granulate add magnesium stearate and always mix 30 minutes, tabletting.Adjuvant uses rationally, and preparation process operation is feasible, and product all meets the requirements through qualitative and quantitative analysis, result, and this formula and processing technology can play raw material efficacy effect.
Above content is detailed description the most made for the present invention, it is impossible to assert that the present invention is embodied as being only limitted to these explanations.For those skilled in the art, without departing from the inventive concept of the premise, it is also possible to make some simple deduction or replace, all should be considered as belonging to the scope of protection of the invention.

Claims (3)

1. a compound dendrobium huoshanense buccal tablet, is characterized in that, is made up of medicated powder and adjuvant,
Described medicated powder includes the component of following mass fraction: Herba Dendrobii extract, 11 parts~23 parts;Rhizoma Polygonati Odorati extract, 17 parts~23 parts;Bulbus Lilii extract, 14 parts~25 parts;
Described adjuvant includes the component of following content: mannitol, for the 20%~30% of described medicated powder quality;Mentholum, for the 1.8% of described medicated powder quality;Polyvidone ketopyrrolidine K30, for the 8.1% of described medicated powder quality;Sucralose, for the 0.1% of described medicated powder quality;Magnesium stearate, for the 0.3%~0.6% of described medicated powder quality;
And preparation method comprises the following steps:
Pulverize: medicated powder and adjuvant cross 120 mesh sieves after pulverizing respectively, it is ensured that material powders uniform color, foreign are mixed into, without stain;
Dispensing: weigh medicated powder and adjuvant according to proportioning;
Mixing, pelletize: medicated powder except for magnesium stearate and adjuvant are thoroughly mixed and are allowed to uniform, add appropriate dehydrated alcohol, make up to hold agglomerating and one touch the most scattered, 16 mesh pelletize;
It is dried: the wet granular made is put in drying equipment and be dried under the conditions of 55 DEG C~60 DEG C, controls moisture 3%~5%;
Granulate: dried granule is put and crosses 14 mesh sieve granulate in pelletizing machine;
Total mixed: the granule made and magnesium stearate are sufficiently mixed uniformly;
Tabletting: by mould punching film-making.
2. compound dendrobium huoshanense buccal tablet as claimed in claim 1 a kind of, is characterized in that, in described mixing, granulation step, the mode that medicated powder except for magnesium stearate and adjuvant are thoroughly mixed is placed in groove and mixes in machine and mix 15 minutes.
3. a kind of compound dendrobium huoshanense buccal tablet as claimed in claim 1, is characterized in that, in described tableting step, needing the temperature controlling job shop is 18 DEG C~26 DEG C, and humidity is 45%~65%.
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CN109123668A (en) * 2018-08-07 2019-01-04 北京筑元吉康医药科技有限责任公司 A kind of health food of strengthen immunity and its application
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