CN104857180A - Anti-fatigue and immunity-improving composition as well as preparation method and application thereof - Google Patents
Anti-fatigue and immunity-improving composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses anti-fatigue and immunity-improving composition as well as a preparation method and an application thereof, and belongs to the field of anti-fatigue healthcare products. The anti-fatigue and immunity-improving composition comprises a coenzyme Q10 and grape seed extract. The coenzyme Q10 is combined with various natural antioxidant substances, the anti-fatigue activities of different compositions are inspected, and finally the inspection discovers that the composition consisting of the coenzyme Q10 and the grape seed extract has most remarkable anti-fatigue activity. The optimal consumption ratio of the coenzyme Q10 to the grape seed extract is further determined through consumption screening experiment. Animal experiments and biochemical index measurement results prove that the composition has very remarkable anti-fatigue activity and immunity-improving function. The composition can be used for preparing anti-fatigue and immunity-improving drugs, healthcare products, drinks, foods or the like, is good in safety, and does not have any side effect.
Description
Technical field
The present invention relates to the compositions of resisting fatigue and raising immunity, particularly relate to the compositions that there is human body resisting fatigue, improve efficacy of immunity that coenzyme Q10 and Semen Vitis viniferae extract are active component, the invention still further relates to preparation method and the application of described compositions, belong to the field of health care products of resisting fatigue and raising immunity.
Background technology
Coenzyme Q10 (coenzyme Q, CoQ) also known as ubiquinone (ubiquinone, UQ, Q), it is a kind of in respiratory chain and the untight coenzyme of protein bound, be the fat-soluble quinones extensively existed in organism, play an important role in proton displacement and electron transmission in human body respiration chain.Coenzyme Q10, as cellular metabolism and Cellular respiration activator, is also important antioxidant and nonspecific immunity strengthening agent.Coenzyme Q10 has oxidized form and reduced form two kinds of forms.After CoQ10 enters human body, need dehydrogenase to change once, the form after conversion is called reduced coenzyme Q 10 again, and this form human body utilizes more direct, so compared with CoQ10, reduced coenzyme Q 10 has and more directly acts in human metabolism.
Fatigue is the physiological acoustic signals process of body complexity, the normal physiological phenomenon of one that must occur when being the mental or physical arrival certain phase of people.Tired appearance, can cause motor capacity reduction, work efficiency reduces, mistake and accident increases; Can not get recovering timely after occurring if tired, accumulate gradually, also can cause " overwork ", there is " overtraining syndrome ", " chronic fatigue syndrome " etc., make body generation endocrine regulation, immunity degradation, even there is organic disease, become the key factor threatening human health.
Therefore, develop and a kind of there is definite resisting fatigue, improve the compositions of efficacy of immunity there is important market value and social meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of resisting fatigue and improves the compositions of immunity, with coenzyme Q10 with Semen Vitis viniferae extract for active component, there is effect of significant resisting fatigue and raising body immunity.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of resisting fatigue and improves the compositions of immunity, comprises following component: coenzyme Q10 and Semen Vitis viniferae extract.
According to mass ratio meter, coenzyme Q10: Semen Vitis viniferae extract=(1-15): (1-20); Be preferably, coenzyme Q10: Semen Vitis viniferae extract=1:11-15; Most preferably be, coenzyme Q10: Semen Vitis viniferae extract=1:13.
Coenzyme Q10 of the present invention is reduced coenzyme Q 10; Compared with CoQ10, reduced coenzyme Q 10 has higher absorbability, higher bioavailability, level in the body only needing less dosage just can reach same.
Reduced coenzyme Q 10 of the present invention can commercialization purchase or chemosynthesis, or from animals and plants extraction and isolation, its extracting method is well known to those skilled in the art.Semen Vitis viniferae extract commercialization can be bought or extract from Semen Vitis viniferae, and its extracting method is well known to those skilled in the art.
Reduced coenzyme Q 10 and multiple Natural Antioxidants tea polyphenols, vitamin C, vitamin E, soybean extract, Semen Vitis viniferae extract etc. combine by the present invention according to a certain percentage, carry out mice burden swimming experiment, investigate the anti-fatigue active of different components.Result shows, reduced coenzyme Q 10 and different Natural Antioxidants combine the resisting fatigue effect all had in various degree.Wherein, the compositions of reduced coenzyme Q 10 and Semen Vitis viniferae extract has extremely significant anti-fatigue active, very significantly (P≤0.001), anti-fatigue active is significantly better than the combination of reduced coenzyme Q 10 and other Natural Antioxidants for Endurance time and blank group difference.
Filtering out reduced coenzyme Q 10 and Semen Vitis viniferae extract is on the basis of composition component, the present invention is optimized the consumption proportion of reduced coenzyme Q 10 and Semen Vitis viniferae extract further.Tested by mice burden swimming, filter out reduced coenzyme Q 10 and Semen Vitis viniferae extract, according to the compositions that mass ratio 1:13 forms, there is extremely significant anti-fatigue active, very significantly (P≤0.001), anti-fatigue active is significantly better than the combination of other consumption for this group Endurance time and blank group difference.
The present invention measures resisting fatigue biochemical indicator, as can be seen from the results, the serum lactic of the compositions that reduced coenzyme Q 10 and Semen Vitis viniferae extract form according to mass ratio 1:13, blood urea nitrogen and MDA level are significantly lower than blank group, and superoxide dismutase (SOD), paddy Guang liver fabk polypeptide (GSH-PX) and hepatic glycogen level are significantly higher than blank group.Also prove from biochemical indicator angle, reduced coenzyme Q 10 and Semen Vitis viniferae extract have extremely significant anti-fatigue active according to the compositions that mass ratio 1:13 forms.
Also there is while the present composition has anti-fatigue effect effect of enhancing immunity.Show according to the compositions experimental result on the impact of mice delayed allergy (DTH) and antibody-producting cell number of different quality than composition by detecting reduced coenzyme Q 10 and Semen Vitis viniferae extract, reduced coenzyme Q 10 and Semen Vitis viniferae extract also can significantly improve mice delayed allergy ability, antibody-producting cell number (P≤0.05) according to the compositions that mass ratio 1:13 forms, and illustrate that the present composition also has the function of extraordinary enhancing immunity.
In resisting fatigue of the present invention and improve on the compositions basis of immunity, add suitable adjuvant or carrier can be prepared into resisting fatigue and improve the medicine of immunity, health product, beverage or food; Wherein, the dosage form of described medicine or health product comprises: tablet, electuary, pill, Emulsion, granule, soft capsule, hard capsule or microcapsule.
Described carrier or adjuvant refer to carrier or the adjuvant of pharmaceutical field routine, such as: diluent, agent of bursting apart, lubricant, excipient, binding agent, fluidizer, filler, surfactant etc.; In addition, other adjuvant can also be added in the composition as flavouring agent and sweeting agent.
Described diluent can be that one or more increase the composition of tablet weight and volume; Conventional diluent comprises lactose, starch, pregelatinized Starch, microcrystalline Cellulose, sorbitol, mannitol and inorganic calcium salt etc.Wherein the most frequently used is lactose, starch, microcrystalline Cellulose.
Described disintegrating agent can be crospolyvinylpyrrolidone (with gross weight than being 2-6%), one or more mixture in cross-linking sodium carboxymethyl cellulose (with gross weight than being 2-6%), alginic acid (with gross weight than being 2-5%), microcrystalline Cellulose (with gross weight than being 5-15%).Wherein with crospolyvinylpyrrolidone (with gross weight ratio for 2-7%), cross-linking sodium carboxymethyl cellulose (with gross weight than being 2-6%) is for good.The best is crospolyvinylpyrrolidone (with gross weight than being 2-6%).
Described lubricant comprises stearic acid, sodium stearate, magnesium stearate, calcium stearate, Polyethylene Glycol, Pulvis Talci, one or more mixture in hydrogenated vegetable oil.Wherein suitable with magnesium stearate.The amount ranges (with gross weight ratio) of lubricant is 0.10-1%, and general consumption is 0.25-0.75%, and optimum amount is 0.5-0.7%.
Described binding agent can be the composition that one or more are conducive to granulating.Can be starch slurry (10-30%, with binding agent gross weight ratio), hydroxypropyl emthylcellulose (2-5%, with binding agent gross weight ratio), polyvinylpyrrolidone (2-20%, with binding agent gross weight ratio), be good with the ethanol water of polyvinylpyrrolidone, the best is 50% ethanol water of polyvinylpyrrolidone.
Described fluidizer can for one or more mixture in micropowder silica gel, Pulvis Talci, magnesium trisilicate.
The composition that described surfactant can improve wettability for one or more and increase drug-eluting.Commonly use as sodium lauryl sulphate (usual range is 0.2-6%, with gross weight ratio).
Technical solution of the present invention compared with prior art, has following beneficial effect:
Reduced coenzyme Q 10 and multiple Natural Antioxidants combine by the present invention, therefrom filter out the resisting fatigue that reduced coenzyme Q 10 and Semen Vitis viniferae extract form and the compositions improving immunity, both compatibilities have effect of significant Synergistic, the two carries out compatibility according to specific consumption proportion again and can obtain extremely significant resisting fatigue, improve effect of immunity, and have no adverse reaction, safety is good.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
1, raw material
Reduced coenzyme Q 10 is purchased from Wei Ao bio tech ltd, Xi'an; Semen Vitis viniferae extract is purchased from Xi'an Chang Yue plant Chemical Co., Ltd.; Tea polyphenols is purchased from Wuxi Lv Bao biological product company limited; Vitamin C and vitamin E are purchased from Qi Yun bio tech ltd, Guangzhou; Propolis is purchased from Changsha Fei Tuo plant company limited; The extracting method list of references of Hijiki polysaccharide (week is quiet. the extracting and developing of Natural Antioxidants and activity research .2008. Zhejiang University. master thesis) method prepare; Radix Ginseng extract is purchased from Shaanxi Jin Tai biological engineering company limited; Soybean extract, Herba Silybi mariani extract, Rhizoma Zingiberis Recens extract are purchased from Shaanxi Long Fu biochemical industry company limited.
The preparation of the compositions of embodiment 1 resisting fatigue and raising immunity
Each raw material (g) is taken: reduced coenzyme Q 10 1, Semen Vitis viniferae extract 13, mix homogeneously, to obtain final product according to following weight.
The preparation of the compositions of embodiment 2 resisting fatigue and raising immunity
Each raw material (g) is taken: reduced coenzyme Q 10 1, Semen Vitis viniferae extract 11, mix homogeneously, to obtain final product according to following weight.
The preparation of the compositions of embodiment 3 resisting fatigue and raising immunity
Each raw material (g) is taken: reduced coenzyme Q 10 1, Semen Vitis viniferae extract 15, mix homogeneously, to obtain final product according to following weight.
The preparation of the compositions of embodiment 4 resisting fatigue and raising immunity
Each raw material (g) is taken: reduced coenzyme Q 10 1, Semen Vitis viniferae extract 20, mix homogeneously, to obtain final product according to following weight.
The preparation of the compositions of embodiment 5 resisting fatigue and raising immunity
Each raw material (g) is taken: reduced coenzyme Q 10 15, Semen Vitis viniferae extract 1, mix homogeneously, to obtain final product according to following weight.
The preparation of embodiment 6 soft capsule
By glycerol 200g, gelatin 320g, pure water 450g, the dissolving of pigment 2g mix homogeneously post-heating, vacuum defoamation, leave standstill insulation, obtaining glue glue; Mix with change glue glue after compositions 60g heating for dissolving prepared by embodiment 1 and roll into ball according to soft capsule Zhanang technique, through shaping, washing ball, drying, picking up ball, obtain soft capsule.
The preparation of embodiment 7 tablet
Compositions 15 grams prepared by Example 2 adds starch 15 grams, mix homogeneously, then mixs homogeneously with 30 grams, dextrin, adds ethanol (50%) soft material processed in right amount; Granulated by 16 order nylon mesh, 60 DEG C of dryings, dry granular, after 16 mesh sieve granulate, adds magnesium stearate 5 grams, tabletting after mix homogeneously.
The preparation of embodiment 8 granule
Compositions prepared by Example 33 grams, mixes with 5 grams of microcrystalline Cellulose, 3 grams of lactose, 1 gram of cross-linking sodium carboxymethyl cellulose, with 3% polyvidone ethanol (50% concentration) for binding agent soft material, cross 40 mesh sieves to granulate, 60 DEG C of dryings, cross 30 mesh sieve granulate, obtain granule.
The compositions prescription screening experiment of experimental example 1 resisting fatigue and raising immunity
1, experimental technique
The prescription of 1.1 compositionss
Combined with Natural Antioxidants tea polyphenols, vitamin C, vitamin E, propolis, Herba Silybi mariani extract, Hijiki polysaccharide, soybean extract, Semen Vitis viniferae extract, Radix Ginseng extract, Rhizoma Zingiberis Recens extract respectively by reduced coenzyme Q 10, mix homogeneously prepares compositions.Wherein, the mass ratio of reduced coenzyme Q 10 and Natural Antioxidants is 1:10.
1.2 animals grouping and administration kind and dosage
7 week age male ICR mouse (20 ± 1g) (Beijing Vital River Experimental Animals Technology Co., Ltd.), the laboratory animal quality certification number: SCXK (capital) 2012-0001.Mice is divided at random blank group and experiment 1-10 group, often organizes 12.Gavage gives mice test medicine once a day, and dosage is 0.15g/Kg, gavage 30 days.
Blank group: gavage normal saline;
Test 1 group: give the compositions that reduced coenzyme Q 10 and tea polyphenols form, gavage;
Test 2 groups: give the compositions that coenzyme Q10 and vitamin C form, gavage;
Test 3 groups: the compositions giving Coenzyme Q10 and Vitamin E composition, gavage;
Test 4 groups: give the compositions that coenzyme Q10 and propolis form, gavage;
Test 5 groups: give the compositions that coenzyme Q10 and Herba Silybi mariani extract form, gavage;
Test 6 groups: give the compositions that coenzyme Q10 and Hijiki polysaccharide form, gavage;
Test 7 groups: give the compositions that coenzyme Q10 and soybean extract form, gavage;
Test 8 groups: give the compositions that coenzyme Q10 and Semen Vitis viniferae extract form, gavage;
Test 9 groups: give the compositions that coenzyme Q10 and Radix Ginseng extract form, gavage;
Test 10 groups: give the compositions that coenzyme Q10 and Rhizoma Zingiberis Recens extract form, gavage.
1.3 mice burden swimming experiments
Detection method: mouse tail, after 30 minutes, is born the sheet lead of upper corresponding body weight 3% by last administration, randomly draws 1 mice for each group, put into water and start timing, exhaust end timing to mice power, record mice first sinking time and power exhausts the time, and the difference of both times characterizes the endurance of mice;
Inspection instrument: adopt diameter 43cm, the bucket of high 40cm, water level height 25cm, water temperature 25 ± 1 DEG C, 4/barrel; Examination criteria: sinking standard is first that mice nose does not have below upstream face first; The power standard of exhausting is that the mice 10s that sinks under the water is non-rising.
1.4 statistical method
Adopt SPSS statistical analysis software to carry out date processing, all data are all with meansigma methods ± standard error
represent, group difference one factor analysis of variance (One-way ANOVA) processes.
2, experimental result
Experimental result is in table 1, and visible reduced coenzyme Q 10 and different Natural Antioxidants combine the resisting fatigue effect all had in various degree.Wherein, the compositions of testing 8 groups of i.e. reduced coenzyme Q 10 and Semen Vitis viniferae extracts has extremely significant anti-fatigue active, very significantly (P≤0.001), anti-fatigue active is significantly better than the combination of reduced coenzyme Q 10 and other Natural Antioxidants for this group Endurance time and blank group difference.
The resisting fatigue testing result of table 1 different components
* represent P≤0.05, compare with blank group and there is significant difference;
* represents P≤0.01, with blank group comparative statistics significant difference;
* * represents P≤0.001, very remarkable with blank group comparative statistics difference.
The prescription consumption screening experiment of the compositions of experimental example 2 resisting fatigue and raising immunity
1, experimental technique
The prescription of 1.1 compositionss
Reduced coenzyme Q 10 and Semen Vitis viniferae extract carry out combining (table 2) according to different amounts proportioning by the present invention on experimental example 1 basis, carry out mice burden swimming experiment according to experimental example 1 method.
The different amounts proportioning of table 2 compositions
2, experimental result
Experimental result is in table 3, and the different amounts of visible reduced coenzyme Q 10 and Semen Vitis viniferae extract combines the resisting fatigue effect all had in various degree.Wherein, the compositions that reduced coenzyme Q 10 and Semen Vitis viniferae extract form according to mass ratio 1:13 has significant anti-fatigue active, very significantly (P≤0.001), anti-fatigue active is significantly better than the combination of other consumptions for this group Endurance time and blank group difference.
The resisting fatigue testing result of table 3 different components
* represents P≤0.01, with blank group comparative statistics significant difference;
* * represents P≤0.001, very remarkable with blank group comparative statistics difference.
The determination experiment of experimental example 3 resisting fatigue biochemical indicator
1, experimental technique
Experimental example 2 mice power exhausted swimming and detecting end after 10 minutes, the mice of plucking blank group and experiment 6 groups is immediately won eyeball and gets blood, and solution takes liver organization.Blood is put 4 DEG C of refrigerators and is left standstill a night, and within second day, 3000r/min, 10min are centrifugal, get serum; Liver organization is placed in ﹣ 80 DEG C and saves backup.
The mensuration of biochemical indicator: serum is for measuring blood lactase acid and blood urea nitrogen, and liver is for measuring hepatic glycogen, malonaldehyde (MDA), superoxide dismutase (SOD) and GKS (GSH-PX).All biochemical reagents boxes build up Bioengineering Research Institute by Nanjing and provide, and assay method carries out according to test kit description.
2, experimental result
As can be seen from Table 4, the serum lactic of the compositions group that reduced coenzyme Q 10 and Semen Vitis viniferae extract form according to mass ratio 1:13, blood urea nitrogen and MDA level are significantly lower than blank group, and superoxide dismutase (SOD), paddy Guang liver fabk polypeptide (GSH-PX) and hepatic glycogen level are significantly higher than blank group.Also prove from biochemical indicator angle, reduced coenzyme Q 10 and Semen Vitis viniferae extract have extremely significant anti-fatigue active according to the compositions that mass ratio 1:13 forms.
The testing result of table 4 resisting fatigue biochemical indicator
* represent P≤0.05, compare with blank group and there is significant difference;
* represents P≤0.01, with blank group comparative statistics significant difference.
The detection of the compositions enhancing immunity function of experimental example 4 resisting fatigue and raising immunity
1, experimental technique
Reduced coenzyme Q 10 and Semen Vitis viniferae extract are prepared compositions respectively according to the table 2 of experimental example 2, mice is divided at random blank group and experiment 1-14 group, often organizes 10, according to experimental example 1 method and dosage gavage mice 30 days once a day.
1.1 delayed allergy (DTH) (foot is hesitated and thickened method)
Mice gives sample after 30 days continuously, mouse peritoneal injection 2% (v/v) SRBC (the every Mus of 0.2m1/) sensitization after 4 days, measure left back sufficient sole of the foot portion thickness, then left back sufficient sole of the foot portion thickness is measured at measuring point subcutaneous injection 20% (v/v) SRBC (the every Mus of 20 μ l/) 24h after injection, same position measures three times, averages.To attack the degree that sufficient sole of the foot portion thickness difference (swelling degree of the paw) in front and back represents DTH.
1.2 antibody-producting cells measure (Jerne improves slide method)
Mice gives sample after 30 days continuously, gets Sanguis caprae seu ovis, and with brine 3 times, centrifugal (2000r/min) l0min, is made into the cell suspension of 2% (v/v) by overstocked SRBC normal saline at every turn, every Mus lumbar injection 0.2m1.Put to death mice after 4 days, get spleen, grind gently, make cell suspension with Hank's liquid, 200 eye mesh screens sieve, washing, centrifugal 2 times, finally by cell suspension in 8m1Hank's liquid, counting cells, and cell concentration is adjusted to 5 × 10
6individual/ml.Mix after the culture medium heating for dissolving of top layer with the pH7.4 of equivalent, the Hank's liquid of 2 times of concentration, subpackage small test tube, often pipe 0.5m1, then in pipe, add 10%SRBC 50 μ l (v/v), 20 μ 1 splenocyte suspensions (5 × 10 with the preparation of SA liquid
6individual/ml), be poured on the slide of brush thin layer agarose after rapid mixing, slide level being buckled after agarose solidifies is placed on slide frame, put into CO2 gas incubator incubation 1.5h, then join in slide groove with the complement (1:8) of SA liquid dilution, after continuing incubation 1.5h, count hemolysis plaque number.
2, experimental result
2.1 compositionss are on the impact of mice delayed allergy (DTH)
Compositions on the impact of mice delayed allergy (DTH) in table 5, test 6 groups of impacts on mice swelling degree of the paw with matched group than significant difference (P≤0.05), the compositions showing resisting fatigue of the present invention and improve immunity has the ability improving mice delayed allergy (DTH).
Table 5 compositions is on the impact of mice delayed allergy (DTH)
* represent P≤0.05, compare with blank group and there is significant difference.
2.2 antibody-producting cell measurement results
The present composition on the impact of mouse antibodies cellulation number in table 6, test 6 groups of impacts on plaque number with matched group than significant difference (P≤0.05), the compositions showing resisting fatigue of the present invention and improve immunity has the ability increasing mouse antibodies cellulation number.
Table 6 compositions is on the impact of mouse antibodies cellulation number
* represent P≤0.05, compare with blank group and there is significant difference.
To sum up, the compositions of resisting fatigue of the present invention and raising immunity can significantly improve mice delayed allergy ability, antibody-producting cell number (P≤0.05), illustrates that the present composition has the function of enhancing immunity.
Claims (10)
1. a compositions for resisting fatigue and raising immunity, is characterized in that, comprise following component: coenzyme Q10 and Semen Vitis viniferae extract.
2. according to compositions according to claim 1, it is characterized in that: according to mass ratio meter, coenzyme Q10: Semen Vitis viniferae extract=1-15:1-20.
3. according to compositions according to claim 2, it is characterized in that: according to mass ratio meter, coenzyme Q10: Semen Vitis viniferae extract=1:11-15.
4. according to compositions according to claim 3, it is characterized in that: according to mass ratio meter, coenzyme Q10: Semen Vitis viniferae extract=1:13.
5., according to the compositions of Claims 1-4 described in any one, it is characterized in that: described coenzyme Q10 is reduced coenzyme Q 10.
6. a preparation method for Claims 1-4 compositions described in any one, is characterized in that, comprising: take each component according to described ratio, mix homogeneously, to obtain final product.
7. the purposes of the compositions of Claims 1-4 described in any one in the medicine of preparation resisting fatigue, health product, beverage or food.
8. the compositions of Claims 1-4 described in any one improves the purposes in the medicine of immunity, health product, beverage or food in preparation.
9. according to the purposes described in claim 7 or 8, it is characterized in that, the dosage form of described medicine comprises: tablet, electuary, pill, Emulsion, granule or capsule; Described capsule is soft capsule, hard capsule or microcapsule.
10. according to the purposes described in claim 7 or 8, it is characterized in that, the dosage form of described health product comprises: tablet, electuary, pill, Emulsion, granule or capsule; Described capsule is soft capsule, hard capsule or microcapsule.
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Cited By (2)
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| CN106177227A (en) * | 2016-08-25 | 2016-12-07 | 成都润馨堂药业有限公司 | A kind of compositions containing coenzyme Q10 strengthening body immunity |
| CN110150633A (en) * | 2017-12-25 | 2019-08-23 | 江南大学（如皋）食品生物技术研究所 | Compound anti-oxidation functional food additive and preparation method thereof |
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| CN103300373A (en) * | 2013-06-26 | 2013-09-18 | 重庆艾视生物科技有限公司 | Lutein and procyanidine composite soft capsule and preparation method thereof |
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| CN101322711A (en) * | 2008-01-09 | 2008-12-17 | 济南老来寿生物技术有限公司 | Health care medicament for resisting fatigue and enhancing immunity and preparation thereof |
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| CN106177227A (en) * | 2016-08-25 | 2016-12-07 | 成都润馨堂药业有限公司 | A kind of compositions containing coenzyme Q10 strengthening body immunity |
| CN110150633A (en) * | 2017-12-25 | 2019-08-23 | 江南大学（如皋）食品生物技术研究所 | Compound anti-oxidation functional food additive and preparation method thereof |
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