CN108635551A - Soboring-up liver-protecting Chinese medicine composition, preparation and preparation method and application - Google Patents
Soboring-up liver-protecting Chinese medicine composition, preparation and preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Abstract
The present invention provides a kind of Soboring-up liver-protecting Chinese medicine composition, preparation and preparation method and application, are related to antialcoholic drugs technical field, and Soboring-up liver-protecting Chinese medicine composition includes the following raw material according to the mass fraction：5 15 parts of turmeric, 10 20 parts of globe artichoke, 5 20 parts of broccoli, 5 10 parts of 15 parts of oyster meat and black pepper, alleviate on the market that there are toxic side effects for chemical classes disintoxicating product, traditional Chinese medicine effect is slow, the bad technical problem of alcohol user's compliance, the present invention utilizes traditional Chinese medicine dietotherapy thought and integration of drinking and medicinal herbs theory prescription compatibility, pass through turmeric, globe artichoke, broccoli, oyster meat and black pepper mutually cooperate with, antialcoholic drugs are made, can not only rapid recovery it is uncomfortable after drinking, protection and maintenance stomach and liver, and it is green safe, it has no toxic side effect, for ensureing that people are physically and mentally healthy, improve dietary structure, it improves the quality of living and maintains social stability and be of great significance.
Description
Technical field
The present invention relates to antialcoholic drugs technical fields, more particularly, to a kind of Soboring-up liver-protecting Chinese medicine composition, preparation and system
Preparation Method and application.
Background technology
China's spirits culture is with a long history and prevailing, have greatly " it is not a banquet without wine ", " no wine is not joyous " wind.China wine drunk at wedding feast person people
Number is numerous, and there are about the males of 60~75% adult often to drink, and the disease ratio that excessive consumption of alcohol induces increases year by year.It is excessive
It drinks and does not easily only result in hepatic injury and corresponding liver pathological changes, and other diseases can be caused, can more particularly cause Human Physiology work(
It can be disorderly or even dead.Alcoholic liver injury caused by excessive consumption of alcohol has become one of the main factor that hepatopathy is suffered from, in
Excessively excessive drinking leads to suffer from the substances such as the pernicious disease such as high blood pressure disease, gastric cancer, protein metabolic disorder occurs and happens occasionally simultaneously for this.
It is alcohol to cause the most common poisonous substance of hepar damnification, and it is difficult that hepar damnification caused by excessive consumption of alcohol has become global medicine
Topic.Therefore, how to sober up, relieve the effect of alcohol and reduce drink the injury to internal organs such as human intestines and stomach, livers demand it is extremely urgent, open
It sends out antialcoholic drugs effective and has great importance and vast market prospect.
In disintoxicating product currently on the market, predominantly chemicals and Chinese medicine preparation, wherein chemicals is mostly excited
The ingredients such as agent, vitamin and amino acid, can quickly play relieve the effect of alcohol, sobering-up functions, but most chemicals relieving mechanism
It is to be only capable of that alcohol is promoted to decompose, plays temporary mitigation, it is difficult to play liver protection effect, toxic side effect is big.And Chinese medicine
Preparation, which is mostly used trifoliate orange, flower of Radix Puerariae, Radix Paeoniae Alba, nutmeg etc., has the Chinese medicine of fine antialcoholism action, but effect is slow, and both
It is drug, alcohol user's compliance is bad.
In view of this, special propose the present invention.
Invention content
One of the objects of the present invention is to provide a kind of Soboring-up liver-protecting Chinese medicine compositions, to alleviate existing production of relieving the effect of alcohol on the market
Product are mainly chemicals and Chinese medicine preparation, and there are toxic side effects for chemical classes disintoxicating product, and traditional Chinese medicine effect is slow, drinks
The bad technical problem of person's compliance.
A kind of Soboring-up liver-protecting Chinese medicine composition provided by the invention, including the following raw material according to the mass fraction：Turmeric 5-
15 parts, 10-20 parts of globe artichoke, 5-20 parts of broccoli, 5-10 parts of 1-5 parts of oyster meat and black pepper.
Further, the Soboring-up liver-protecting Chinese medicine composition includes the following raw material according to the mass fraction：Turmeric 10-15
5-10 parts of part, 15-20 parts of globe artichoke, 8-15 parts of broccoli, 1-5 parts of oyster meat and black pepper.
Further, the Soboring-up liver-protecting Chinese medicine composition further includes 5-10 parts of Schisandra chinensis and Radix Paeoniae Alba according to the mass fraction
5-10 parts.
The second object of the present invention is to provide a kind of Soboring-up liver-protecting Chinese medicine preparation, including Soboring-up liver-protecting provided by the invention
Chinese medicine composition.
Further, the Soboring-up liver-protecting Chinese medicine preparation further includes pharmaceutically acceptable auxiliary material；
Preferably, the auxiliary material includes excipient, binder, filler, lubricant, antioxidant, preservative or thickening
At least one of agent.
Further, the Soboring-up liver-protecting Chinese medicine preparation is oral preparations；
Preferably, the dosage form of the preparation is tablet, powder, pill, capsule, granule or oral solution.
The third object of the present invention is to provide a kind of preparation method of Soboring-up liver-protecting Chinese medicine capsules, including walks as follows
Suddenly：
(a) globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis are done respectively
Ultramicro grinding is carried out after dry, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder
With optional Fructus Schisandrae Chinensis powder；
(b) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and optional
Fructus Schisandrae Chinensis powder is uniformly mixed, and is poured into capsule shells, is obtained Soboring-up liver-protecting Chinese medicine capsules.
The fourth object of the present invention is to provide a kind of preparation method of Soboring-up liver-protecting Chinese herbal granules, including walks as follows
Suddenly：
(o) globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis are done respectively
Ultramicro grinding is carried out after dry, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder
With optional Fructus Schisandrae Chinensis powder；
(p) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and optional
Fructus Schisandrae Chinensis powder is uniformly mixed, and successively by softwood processed, pelleting and drying, obtains Soboring-up liver-protecting Chinese herbal granules.
The fifth object of the present invention is to provide a kind of preparation method of Soboring-up liver-protecting Chinese medicinal tablet, include the following steps：
(m) ultra micro is carried out after being separately dried globe artichoke, turmeric, broccoli, oyster meat, black pepper, Radix Paeoniae Alba and Schisandra chinensis
It crushes, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, Radix Paeoniae Alba and Fructus Schisandrae Chinensis powder；
(n) globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, herbaceous peony powder and Fructus Schisandrae Chinensis powder are mixed
Uniformly, tabletting is carried out, Soboring-up liver-protecting Chinese medicinal tablet is obtained.
The sixth object of the present invention is to provide application of the above-mentioned Soboring-up liver-protecting Chinese medicine composition in drug or health products.
The seventh object of the present invention is to provide application of the above-mentioned Soboring-up liver-protecting Chinese medicine preparation in drug or health products.
The present invention utilizes traditional Chinese medicine dietotherapy thought and integration of drinking and medicinal herbs theory prescription compatibility, blue by turmeric, globe artichoke, west
Flower, oyster meat and black pepper mutually cooperate with, and antialcoholic drugs are made, can not only rapid recovery it is uncomfortable after drinking, protection and raise intestines
Stomach and liver, and it is green safe, it has no toxic side effect, for ensureing that people are physically and mentally healthy, improves dietary structure, improve life matter
It measures and maintains social stability and be all of great significance.
Soboring-up liver-protecting Chinese medicine preparation provided by the invention, including Soboring-up liver-protecting Chinese medicine composition provided by the invention, not only
Can rapid recovery it is uncomfortable after drinking, protection and raise stomach and liver, and green safe, have no toxic side effect, for ensureing people
It is physically and mentally healthy, improve dietary structure, improving the quality of living and maintaining social stability all is of great significance.
The preparation method of Soboring-up liver-protecting Chinese medicine preparation provided by the invention is simple for process, easy to operate, can be suitable for work
The big production of industryization improves production efficiency.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of Soboring-up liver-protecting Chinese medicine compositions, including press mass parts
The following raw material of number meter：5-15 parts of turmeric, 10-20 parts of globe artichoke, 5-20 parts of broccoli, 1-5 parts of oyster meat and black pepper 5-10
Part.
In the present invention, the typical but non-limiting mass fraction of turmeric as 5,5.5,6,6.5,7,7.5,8,8.5,
9,9.5,10,10.5,11,11.5,12,12.5,13,13.5,14,14.5 or 15 parts.
Turmeric has norcholesterol, and cholagogic, reducing blood lipid, balancing blood pressure is anti-inflammatory, reinforces stomach technical ability, improves liver function, helps
Liver detoxification, solution are still drank after a night, anti-oxidant, help wound healing.
In the present invention, the typical but non-limiting mass fraction of globe artichoke as 10,10.5,11,11.5,12,
12.5,13,13.5,14,14.5,15,15.5,16,16.5,17,17.5,18,18.5,19,19.5 or 20 parts.
Globe artichoke can make the functional activation of liver and kidney, promote liver cell regeneration, help the secretion of internal bile,
Participate in the metabolism of cholesterol and fat.
In the present invention, the typical but non-limiting mass fraction of broccoli as 5,5.5,6,6.5,7,7.5,8,
8.5,9,10,11,12,13,14,15,16,17,18,19 or 20 parts.
Broccoli contains abundant ascorbic acid, can enhance the detoxification ability of liver, improves immunity of organisms.
In the present invention, the typical but non-limiting mass fraction of oyster meat as 1,1.2,1.5,1.8,2,2.2,
2.5,2.8,3,3.2,3.5,3.8,4,4.2,4.5,4.8 or 5 parts.
Oyster meat can promote choleresis, exclude the neutral fat being deposited in liver, improve the detoxication of liver.
In the present invention, the typical but non-limiting mass fraction of black pepper as 5,5.5,6,6.5,7,7.5,8,
8.5,9,9.5 or 10 parts.
The main component of black pepper is pipering, also contains a certain amount of aromatic oil, crude protein, crude fat and solubility
Nitrogen, energy deodorization, solution is greasy, aid digestion, while can also stimulating intestine and stomach secretion.
The present invention utilizes traditional Chinese medicine dietotherapy thought and integration of drinking and medicinal herbs theory prescription compatibility, blue by turmeric, globe artichoke, west
Flower, oyster meat and black pepper mutually cooperate with, and antialcoholic drugs are made, can not only rapid recovery it is uncomfortable after drinking, protection and raise intestines
Stomach and liver, and it is green safe, it has no toxic side effect, for ensureing that people are physically and mentally healthy, improves dietary structure, improve life matter
It measures and maintains social stability and be all of great significance.
In the preferred embodiment of the present invention, Soboring-up liver-protecting Chinese medicine composition further includes five according to the mass fraction
5-10 parts of 5-10 parts of taste and Radix Paeoniae Alba.
Schisandra chinensis contains schizandrin and vitamin C, resin, tannin and a small amount of carbohydrate.Have astringe the lung to stop cough, nourish it is puckery essence,
The benefits of antidiarrheal hidroschesis.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of Schisandra chinensis as 5,5.5,6,
6.5,7,7.5,8,8.5,9,9.5 or 10 parts.
Radix Paeoniae Alba is the dry root of Chinese herbaceous peony, with smooth liver and relieve pain, the effect of nourishing blood for regulating menstruation, astringing YIN to stop sweating.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of Radix Paeoniae Alba as 5,5.5,6,
6.5,7,7.5,8,8.5,9,9.5 or 10 parts.
It is mutually cooperateed with turmeric, globe artichoke, broccoli, oyster meat and black pepper by the way that Radix Paeoniae Alba and Schisandra chinensis will be added, energy
The drug effect of Soboring-up liver-protecting Chinese medicine composition is enough effectively improved, discomfort after drinking, protection and maintenance stomach and liver are faster alleviated.
According to the second aspect of the invention, the present invention provides a kind of Soboring-up liver-protecting preparation, including it is provided by the invention
Soboring-up liver-protecting Chinese medicine composition.
Soboring-up liver-protecting Chinese medicine preparation provided by the invention, including Soboring-up liver-protecting Chinese medicine composition provided by the invention, not only
Can rapid recovery it is uncomfortable after drinking, protection and raise stomach and liver, and green safe, have no toxic side effect, for ensureing people
It is physically and mentally healthy, improve dietary structure, improving the quality of living and maintaining social stability is of great significance.
In the preferred embodiment of the present invention, Soboring-up liver-protecting Chinese medicine preparation further includes pharmaceutically acceptable auxiliary
Material, with according to the requirement of specific product so that different dosage forms is made in Soboring-up liver-protecting Chinese medicine composition and auxiliary material, in order to use
Person takes.
In present invention further optimization embodiment, auxiliary material include but not limited to excipient, binder, filler,
One or more of lubricant, antioxidant, preservative or thickener.
In the preferred embodiment of the present invention, Soboring-up liver-protecting Chinese medicine preparation provided by the invention is oral preparations.
In present invention further optimization embodiment, the dosage form of Soboring-up liver-protecting Chinese medicine preparation is tablet, powder, ball
Agent, capsule, granule or oral solution.
According to the third aspect of the present invention, the present invention provides the systems of above-mentioned integration of drinking and medicinal herbs relieving alcoholism and protecting liver Chinese medicine capsules
Preparation Method includes the following steps：
(a) ultra micro is carried out after being separately dried globe artichoke, turmeric, broccoli, oyster meat, black pepper, Radix Paeoniae Alba and Schisandra chinensis
It crushes, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, herbaceous peony powder and Fructus Schisandrae Chinensis powder；
(b) globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, white peony root powder and Fructus Schisandrae Chinensis powder are mixed
Uniformly, it pours into capsule shells, obtains Soboring-up liver-protecting Chinese medicine capsules.
In the present invention, capsule shells are commercially available by commercially available.
According to the fourth aspect of the present invention, the present invention provides the preparation method of above-mentioned Soboring-up liver-protecting Chinese herbal granules,
Include the following steps：
(o) ultra micro is carried out after being separately dried globe artichoke, turmeric, broccoli, oyster meat, black pepper, Radix Paeoniae Alba and Schisandra chinensis
It crushes, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, herbaceous peony powder and Fructus Schisandrae Chinensis powder；
(p) globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, Radix Paeoniae Alba and Schisandra chinensis are uniformly mixed,
Successively by softwood processed, pelleting and drying, Soboring-up liver-protecting Chinese herbal granules are obtained.
In the preferred embodiment of the present invention, in step (p), appropriate amount of auxiliary materials is added, in favor of softwood processed and
It is more convenient during pelleting.
In present invention further optimization embodiment, auxiliary material is selected from pharmaceutically acceptable excipient, binder, fills out
It fills one or more of in agent, lubricant, antioxidant and preservative or thickener.
According to the fifth aspect of the present invention, the present invention provides the preparation method of above-mentioned Soboring-up liver-protecting Chinese medicinal tablet, packets
Include following steps：
(m) globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis are done respectively
Ultramicro grinding is carried out after dry, obtains globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder
With optional Fructus Schisandrae Chinensis powder；
(n) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and optional
Fructus Schisandrae Chinensis powder is uniformly mixed, and is carried out tabletting, is obtained Soboring-up liver-protecting Chinese medicinal tablet.
In the preferred embodiment of the present invention, Soboring-up liver-protecting Chinese medicine preparation can also prepare in accordance with the following steps and
At：
(1) globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis are done respectively
It crushes, obtain globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and appoints after dry
The Fructus Schisandrae Chinensis powder of choosing；
(2) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and optional
Fructus Schisandrae Chinensis powder extracts respectively, obtains Carlina acaulis extract, Turmeric P.E, Caulis et Folium Brassicae capitatae, oyster, black
Fructus Piperis extract, optional radix paeoniae alba extraction and optional Schisandra chinens P.E；
(3) by Carlina acaulis extract, Turmeric P.E, Caulis et Folium Brassicae capitatae, oyster, Fructus piperis nigrum extract,
Optional radix paeoniae alba extraction and optional Schisandra chinens P.E are uniformly mixed, and can pharmaceutically be connect according to the addition of the needs of different dosage forms
The auxiliary material received prepares piece agent, powder, pill, capsule, granule or oral solution etc..
The preparation method of Soboring-up liver-protecting Chinese medicine preparation provided by the invention is simple for process, easy to operate, can be suitable for work
The big production of industryization improves production efficiency.
According to the fourth aspect of the present invention, the present invention provides Soboring-up liver-protecting Chinese medicine compositions in drug or health products
Application.
According to the fifth aspect of the present invention, the present invention provides Soboring-up liver-protecting Chinese medicine preparations in drug or health products
Using.
Technical solution provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
A kind of Soboring-up liver-protecting Chinese herbal granules are present embodiments provided, are prepared by raw material according to the mass fraction：Ginger
5 parts yellow, 20 parts of globe artichoke, 15 parts of broccoli, 5 parts of oyster meat, 5 parts of black pepper.
Embodiment 2
A kind of Soboring-up liver-protecting Chinese herbal granules are present embodiments provided, are prepared by raw material according to the mass fraction：Ginger
10 parts yellow, 15 parts of globe artichoke, 15 parts of broccoli, 4 parts of oyster meat, 6 parts of black pepper.
Embodiment 3
A kind of Soboring-up liver-protecting Chinese herbal granules are present embodiments provided, are prepared by raw material according to the mass fraction：Ginger
15 parts yellow, 15 parts of globe artichoke, 9 parts of broccoli, 1 part of oyster meat, 10 parts of black pepper.
Embodiment 4
Present embodiments provide a kind of Soboring-up liver-protecting Chinese herbal granules, the present embodiment with embodiment 3 the difference is that,
Further include 7 parts of 8 parts of Radix Paeoniae Alba and Schisandra chinensis according to the mass fraction in raw material.
Embodiment 5
Present embodiments provide a kind of Soboring-up liver-protecting Chinese herbal granules, the present embodiment with embodiment 3 the difference is that,
It further include 15 parts of Radix Paeoniae Alba according to the mass fraction in raw material.
Embodiment 6
Present embodiments provide a kind of Soboring-up liver-protecting Chinese herbal granules, the present embodiment with embodiment 3 the difference is that,
It further include 15 parts of Schisandra chinensis according to the mass fraction in raw material.
Embodiment 7
Present embodiments provide a kind of Soboring-up liver-protecting Chinese herbal granules, the present embodiment with embodiment 3 the difference is that,
Further include 2 parts of 13 parts of Schisandra chinensis and Radix Paeoniae Alba according to the mass fraction in raw material.
Embodiment 8
Present embodiments provide a kind of preparation method of Soboring-up liver-protecting Chinese herbal granules, the shield of sobering up that embodiment 1-7 is provided
Liver Chinese herbal granules are prepared in the method, specifically comprise the following steps：
(1) globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis are done respectively
Ultramicro grinding is carried out after dry, is sieved with 100 mesh sieve, and is obtained globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, is appointed
The herbaceous peony powder of choosing and optional Fructus Schisandrae Chinensis powder；
(2) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional white peony root powder and optional
Fructus Schisandrae Chinensis powder is uniformly mixed, and successively by softwood processed, pelleting and drying, obtains relieving alcoholism and protecting liver Chinese herbal granules.
Comparative example 1
This comparative example provides a kind of naloxone hydrochloride sublingual tablet.
Comparative example 2
This comparative example provides one kind and relieves the effect of alcohol granule, is prepared by raw material according to the mass fraction：2 parts of turmeric, court
2.5 parts of 25 parts of fresh Ji, 25 parts of broccoli, 0.5 part of oyster meat and black pepper.
Comparative example 3
This comparative example provides one kind and relieves the effect of alcohol granule, is prepared by raw material according to the mass fraction：20 parts of turmeric, court
13 parts of 5 parts of fresh Ji, 2 parts of broccoli, 10 parts of oyster meat and black pepper.
Comparative example 4
This comparative example provides one kind and relieves the effect of alcohol granule, and difference lies in turmeric is not added to this comparative example with embodiment 3.
Comparative example 5
This comparative example provides one kind and relieves the effect of alcohol granule, and difference lies in be not added this comparative example in raw material with embodiment 3
Globe artichoke.
Comparative example 6
This comparative example provides one kind and relieves the effect of alcohol granule, and difference lies in be not added this comparative example in raw material with embodiment 3
Broccoli.
Comparative example 7
This comparative example provides one kind and relieves the effect of alcohol granule, and difference lies in be not added this comparative example in raw material with embodiment 3
Oyster meat.
Comparative example 8
This comparative example provides one kind and relieves the effect of alcohol granule, and difference lies in be not added this comparative example in raw material with embodiment 3
Black pepper.
The preparation method for the granule that relieves the effect of alcohol that comparative example 2-8 is provided is with embodiment 3, and details are not described herein.
Test example 1
ICR male mices 240, weight 21-25g are chosen, 24 groups, respectively 1-24 groups are randomly divided into, prohibits before testing and feeds
12 hours, 39 DEG C of white wine (being equivalent to adult drinking amount 100mL) of every test mice gavage 0.14mL/10g, then gavage each group
Corresponding solution, wherein 1-3 the groups granule that relieves the effect of alcohol that gavage embodiment 1 provides respectively, dosage dosage is respectively 0.13mg/
10g, 0.26mg/10g, 0.39mg/10g, the 4-6 groups granule that relieves the effect of alcohol that gavage embodiment 2 provides respectively, dosage dosage difference
For 0.13mg/10g, 0.26mg/10g, 0.39mg/10g, the 7-9 groups granule that relieves the effect of alcohol that gavage embodiment 3 provides respectively, administration
Dosage is respectively 0.13mg/10g, 0.26mg/10g, 0.39mg/10g, 10-12 groups the relieving the effect of alcohol of providing of gavage embodiment 4 respectively
Grain, dosage are respectively 0.13mg/10g, 0.26mg/10g, 0.39mg/10g, 13-15 parts of not respectively administration embodiment 5-7
The granule that relieves the effect of alcohol provided, dosage are 0.39mg/10g, and 16 groups are blank control group, and 17 groups of administration comparative examples 1 provide
The Western medicine that relieves the effect of alcohol, the granule that relieves the effect of alcohol that comparative example 2-8 is provided is administered in 18-24 groups respectively, and dosage is 0.39mg/10g.This
State of intoxication and time of the experiment by " righting reflex " experimental observation mouse.Test mice gavage white wine back to be positioned over examination
It tests on platform, if backwards to state retention time at 40 seconds or more, concludes that test mice is state of intoxication, righting reflex experiment
Otherwise failure is non-state of intoxication.The hangover slow phenomenon of stride is that test mice mouth fills certain time interior appearance after white wine
It walks slow and unstable present situation, the results are shown in Table 1.
Table 1 relieves the effect of alcohol influence of the granule to mice drunk state and time
From table 1,1-12 groups (the embodiment 1-4 of various dose), 13-15 groups (high dose embodiment 5-7) and 16 groups are (empty
White control group) comparison as can be seen that the drunk rate of 1-15 groups is far below 16 groups, and there are not dead mouse feelings in 1-15 groups
Condition, 16 groups of the death rate reaches 30%, while the hangover time of 1-15 groups and tolerance time are considerably longer than 16 groups, and the drunk time is aobvious
Write and be less than 16 groups, what this illustrated that embodiment 1-7 provides relieve the effect of alcohol granule can rapid recovery it is uncomfortable after drinking, reduce drunk rate, subtract
Light influence of the alcohol to stomach and liver, protects body health.Embodiment 1- is can be seen that from the comparison of 1-15 groups and the 16th group
The dispelling effects of alcohol of 7 granules that relieve the effect of alcohol provided is suitable with naloxone hydrochloride sublingual tablet, but the solution that 1-7 of the embodiment of the present invention is provided
Wine granule is all prepared using integration of drinking and medicinal herbs substance, green safe, is had no toxic side effect, and body needs can be more complied with.
From the comparison of 1-15 groups and 18-24 groups as can be seen that the drunk rate of the granule that relieves the effect of alcohol that embodiment 1-7 is provided and liquor-saturated
The wine time is substantially less than comparative example 2-8, and hangover time and tolerance time are considerably longer than comparative example 2-8, this illustrates that the present invention passes through
It is mutually cooperateed with, can be effectively shortened drunk using the turmeric of extra fine quality number, globe artichoke, broccoli, oyster meat and black pepper
Time reduces drunk rate, mitigates influence of the alcohol to stomach and liver, protects body health.
In addition, can be seen that the granule that relieves the effect of alcohol of high dose group from the comparison of 1-3 groups, 2-6 groups, 3-9 and 10-12 groups
Dispelling effects of alcohol be better than low dose group, and embodiment 4 provide the granule that relieves the effect of alcohol dispelling effects of alcohol it is best.
The comparison of 10-12 groups and 1-9 groups and 12-15 groups, which can be seen that, passes through the raw material in Soboring-up liver-protecting Chinese herbal granules
It is middle be added extra fine quality number Radix Paeoniae Alba and Schisandra chinensis so that Radix Paeoniae Alba, Schisandra chinensis and turmeric, globe artichoke, broccoli, oyster meat and
Black pepper mutually cooperates with, and can effectively improve the drug effect of Soboring-up liver-protecting Chinese medicine composition, faster alleviates uncomfortable after drinking, protection and tune
Support stomach and liver.
Test example 2
160 people of male is chosen, age 20-45 Sui, is randomly divided into 16 groups, it is white to drink 100mL39 degree at everyone by every group of 10 people
After drinking, 1-7 groups drink embodiment 1-7 and provide the granule 170mg that relieves the effect of alcohol respectively, and 8 groups are blank control group, and it is pure to drink same volume
Water, 9-16 groups are drunk the granule that relieves the effect of alcohol that comparative example 1-8 is provided, are surveyed with pump gas formula alcohol tester after 15 minutes respectively
Examination, the results are shown in Table 2.
2 tester's alcohol content table of table
| Group | Alcohol content mean value (mg/mL) |
| 1 group (embodiment 1) | 22.4 |
| 2 groups (embodiments 2) | 17.2 |
| 3 groups (embodiments 3) | 13.1 |
| 4 groups (embodiments 4) | 10.5 |
| 5 groups (embodiments 5) | 12.8 |
| 6 groups (embodiments 6) | 12.5 |
| 7 groups (embodiments 7) | 12.1 |
| 8 groups (blank control groups) | 83.2 |
| 9 groups (comparative examples 1) | 25.4 |
| 10 groups (comparative examples 2) | 26.5 |
| 11 groups (comparative examples 3) | 27.4 |
| 12 groups (comparative examples 4) | 29.1 |
| 13 groups (comparative examples 5) | 28.7 |
| 14 groups (comparative examples 6) | 28.2 |
| 15 groups (comparative examples 7) | 29.4 |
| 16 groups (comparative examples 8) | 27.8 |
1-7 groups can be seen that the dispelling effects of alcohol for the granule that relieves the effect of alcohol that embodiment 1-7 is provided with the comparison of 8-9 groups from table 2
Significantly, and slightly above the Western medicine group of relieving the effect of alcohol that comparative example 1 provides.
1-3 groups can be seen that the effect of relieving the effect of alcohol for the granule that relieves the effect of alcohol that embodiment 1-3 is provided with the comparison of 10-16 groups from table 2
Fruit is significantly better than comparative example 2-8, this illustrates the present invention by using the turmeric of extra fine quality number, globe artichoke, broccoli, oyster
Meat and black pepper mutually cooperate with, and dispelling effects of alcohol significantly improves.
4 groups and 1-3 groups and the comparison of 5-7 groups are as can be seen that relieving the effect of alcohol for the granule that relieves the effect of alcohol that embodiment 4 provides from table 2
Significant effect is better than embodiment 1-3 and embodiment 5-7, and specific matter is added in this explanation in the raw material of Soboring-up liver-protecting Chinese herbal granules
Measure the Radix Paeoniae Alba and Schisandra chinensis of number so that Radix Paeoniae Alba, Schisandra chinensis and turmeric, globe artichoke, broccoli, oyster meat and black pepper are mutually assisted
Together, the drug effect of Soboring-up liver-protecting Chinese medicine composition can be effectively improved, discomfort after drinking, protection and maintenance stomach and liver are faster alleviated
It is dirty.Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；Although ginseng
According to foregoing embodiments, invention is explained in detail, it will be understood by those of ordinary skill in the art that：It still may be used
With technical scheme described in the above embodiments is modified, either which part or all technical features are carried out etc.
With replacement；And these modifications or replacements, various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution
Range.
Claims (10)
1. a kind of Soboring-up liver-protecting Chinese medicine composition, which is characterized in that including the following raw material according to the mass fraction：Turmeric 5-15
5-10 parts of part, 10-20 parts of globe artichoke, 5-20 parts of broccoli, 1-5 parts of oyster meat and black pepper.
2. Soboring-up liver-protecting Chinese medicine composition according to claim 1, which is characterized in that as follows including according to the mass fraction
Raw material：8-10 parts of 10-15 parts of turmeric, 15-20 parts of globe artichoke, 8-15 parts of broccoli, 1-4 parts of oyster meat and black pepper.
3. Soboring-up liver-protecting Chinese medicine composition according to claim 1, which is characterized in that further include five according to the mass fraction
5-10 parts of 5-10 parts of taste and Radix Paeoniae Alba.
4. a kind of Soboring-up liver-protecting Chinese medicine preparation, which is characterized in that including claim 1-3 any one of them Soboring-up liver-protecting Chinese medicines
Composition.
5. Soboring-up liver-protecting Chinese medicine preparation according to claim 4, which is characterized in that further include pharmaceutically acceptable auxiliary
Material；
Preferably, the auxiliary material includes in excipient, binder, filler, lubricant, antioxidant, preservative or thickener
At least one.
6. Soboring-up liver-protecting Chinese medicine preparation according to claim 4, which is characterized in that the preparation is oral preparations；
Preferably, the dosage form of the preparation is tablet, powder, pill, capsule, granule or oral solution.
7. the preparation method of Soboring-up liver-protecting Chinese medicine capsules according to claim 6, which is characterized in that including walking as follows
Suddenly：
(a) after globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis being separately dried
Ultramicro grinding is carried out, globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder are obtained and is appointed
The Fructus Schisandrae Chinensis powder of choosing；
(b) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and the optional five tastes
Sub- powder is uniformly mixed, and is poured into capsule shells, is obtained Soboring-up liver-protecting Chinese medicine capsules.
8. the preparation method of Soboring-up liver-protecting Chinese herbal granules according to claim 6, which is characterized in that including walking as follows
Suddenly：
(o) by globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis, be separately dried after
Ultramicro grinding is carried out, globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage and black pepper are obtained；
(p) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis
It is uniformly mixed, successively by softwood processed, pelleting and drying, obtains Soboring-up liver-protecting Chinese herbal granules；
Preferably, in step (p), auxiliary material is added.
9. the preparation method of Soboring-up liver-protecting Chinese medicinal tablet according to claim 6, which is characterized in that include the following steps：
(m) after globe artichoke, turmeric, broccoli, oyster meat, black pepper, optional Radix Paeoniae Alba and optional Schisandra chinensis being separately dried
Ultramicro grinding is carried out, globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder are obtained and is appointed
The Fructus Schisandrae Chinensis powder of choosing；
(n) by globe artichoke powder, curcuma powder, broccoli powder, oyster digested tankage, black pepper, optional herbaceous peony powder and the optional five tastes
Sub- powder is uniformly mixed, and is carried out tabletting, is obtained Soboring-up liver-protecting Chinese medicinal tablet.
10. according to claim 1-3 any one of them Soboring-up liver-protecting Chinese medicine compositions or claim 4-6 any one of them
Application of the Soboring-up liver-protecting Chinese medicine preparation in drug or health products.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110507786A (en) * | 2019-08-16 | 2019-11-29 | 爱可道生物科技有限公司 | A kind of arithoke compound product with protect liver, preparation method and application |
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| CN110507786A (en) * | 2019-08-16 | 2019-11-29 | 爱可道生物科技有限公司 | A kind of arithoke compound product with protect liver, preparation method and application |
| CN112913957A (en) * | 2021-03-03 | 2021-06-08 | 广州市诺品健康科技有限公司 | Liver-protecting sargassum salina tablet candy and preparation method thereof |
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Application publication date: 20181012 |