CN109549207A - A kind of Traditional Chinese medicine compound health food and preparation method thereof with effect of weight reducing - Google Patents
A kind of Traditional Chinese medicine compound health food and preparation method thereof with effect of weight reducing Download PDFInfo
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- CN109549207A CN109549207A CN201710881666.6A CN201710881666A CN109549207A CN 109549207 A CN109549207 A CN 109549207A CN 201710881666 A CN201710881666 A CN 201710881666A CN 109549207 A CN109549207 A CN 109549207A
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- A—HUMAN NECESSITIES
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Abstract
The embodiment of the present invention provides a kind of Traditional Chinese medicine compound health food and preparation method thereof with effect of weight reducing, is related to field of health care products, product safety, nontoxic, and anorexia diarrhea, does not lower weight and do not reduce physical strength, to achieve the effect that healthy fat reducing.The Traditional Chinese medicine compound health food with effect of weight reducing is using Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed, rhizoma alismatis as Effect raw material, the weight percent of the Effect raw material are as follows: the summation of Poria cocos 12-25%, radish seed 10-20%, hawthorn 5-15%, lotus leaf 5-15%, ginger 1-10%, jujube 1-10%, semen coicis 12-25%, cassia seed 5-20%, rhizoma alismatis 1-12%, the weight percent of the Effect raw material are no more than 100%.
Description
Technical field
The present invention relates to field of health care products more particularly to a kind of Traditional Chinese medicine compound health foods and its system with effect of weight reducing
Preparation Method.
Background technique
With the development of economy with the variation of life style, the unreasonable and some other factor of people's diet causes
Obesity rates, which are presented, continues ascendant trend, and the people with soft-fat type is more and more.Obesity is to the image of people, life and works all
Inconvenience is brought, no matter fat illness rate is in developed country or developing country, in adult and children, all with surprising
Speed increases.Show that overweight and obesity rates respectively reach 36.2% and 13.5% according to Beijing area sample survey results.In the U.S.,
64.5% crowd is in overweight and obese state, has the disease incidence of 10%-15% or so in China city, and have rejuvenation to incline
To.Overweight people suffers from mostly 2 times of likelihood ratio regular severe one of coronary heart disease, Hypertension incidence 2-6 more than regular severe one according to statistics
Times, more seriously the service life of overweight people will be obviously shortened, and obesity has seriously affected people's lives and health.Meanwhile it is anti-
The total cost cumulative year after year of obesity and its related complication is controlled, increases within 2010 90700000000 dollars, 2012 up to 147,000,000,000
Dollar, obesity has become medical field, biological educational circles problem in the urgent need to address.
The mode of weight-reducing is varied, keeps fit through sport, diet weight-reducing, weight reduction with drugs etc., because of the limitation of Working Life condition,
Overweight people is more likely to weight reduction with drugs.Adiposis patient multiselect takes effective Western medicine at present, and Western medicine preparation mainly passes through wherein
The ingredients such as the diuretics, ephedrine, the amphetamine that contain have expensive, drug-dependent strong, poison to reach fat-reducing effect
The drawbacks such as side effect is big, and easily rebound, are also easy to produce the adverse reactions such as anorexia, diarrhea, often influence normal living and diet and sleep
It sleeps, brings the worry of more physical problems.
Pure Chinese medicine weight-reducing is a kind of safe method of weight-reducing, and Chinese medicine thinks overweight people's more deficiency of vital energy and acking in strength, hematogenous blockage, gas
The turbid phlegm wet of machine stasis, rouge, thus in fat accumulation body, it is easily formed over time fat.Fat sick position is mainly in spleen, with kidney qi
Void, the functional disturbance of liver and gallbladder cardiopulmonary are closely related.Based on Chinese traditional medicine principle, using qi-restoratives invigorating the spleen as principle, effects a permanent cure with kidney and spleen invigorating, control
The sharp aquation stasis of blood of mark by drying, invigorating the spleen, the methods of promoting blood circulation, helps conditioning the five internal organs and endocrine, enables qi-blood circulating, will be internal
Excessive moisture, toxin discharge, to improve metabolic capabilities.Modern medicine and pharmaceutical research discovery simultaneously, many tradition
Chinese medicinal plant, such as dark green tea, the sterculia seed, lotus leaf, Radix Glycyrrhizae, rheum officinale etc. contain anthocyan, Polyphenols, flavonoids composition, can be with
Pass through inhibition PECTORAL LIMB SKELETON proliferation and a variety of ways such as differentiation, the absorption of inhibition fat and synthesis, the consumption of increase human body energy
Diameter mode, reduces the deposition of body fat, to achieve the purpose that weight-reducing.Product of the present invention is pure Chinese medicine plant extracts, is matched
Side combine traditional Chinese and western medicine theory basis, have many advantages, such as safely, effectively, be not easy to rebound.
Nowadays slimming health food type is more in society, kind is many and diverse, many equal patent applied fors of product.
It is main former that " a kind of slimming health food " (CN200910228551.2), which is with Poria cocos, Radix Astragali, rhizoma alismatis, hawthorn,
Material, is added flavoring agent, is made of conventional method, " a kind of slimming health food and preparation method thereof "
It (CN200610130305.X) is to be constituted with ginseng, Radix Astragali, Poria cocos, Fructus Corni, ginger, QI invigorating salubrity, usage are simple simultaneously for weight-reducing
Folk prescription is just." a kind of slimming health food and preparation method thereof " (number of patent application 201210283797.1) is with white rue, L- apple
Tartaric acid, L-carnitine-L-tartrate, konjaku flour are raw material, by inhibiting starch to absorb, the conversion of promotion energy, prevent fatty shape
At reaching effect of weight reducing.
Foregoing invention compatibility is simple, and functional component is indefinite, is not pure Chinese medicine preparation mostly.The research and development of present invention combination Western medicine
Theory rejects without effect ingredient, and (ursolic acid, flavone of hawthorn fruit, pachymaran, radish seed are unsaturated for enrichment high activity Effect raw material
Fatty acid, lotus leaf alkaloid and polyphenol component), the absorption of fat can be inhibited by inhibiting PECTORAL LIMB SKELETON proliferation and differentiation
And synthesis, increase the approach such as the consumption of human body energy, reduce the deposition of body fat, to achieve the purpose that weight-reducing.Embodiment
Technical problem to be solved is, provides a kind of raw material diversification, non-anorexia diarrhea, the toxic side effect for lowering weight small subtract
Fertile health food.
Summary of the invention
The Traditional Chinese medicine compound health food and preparation method thereof with effect of weight reducing that the embodiment of the invention provides a kind of, in conjunction with
Traditional Chinese and western medicine is to the fat cognition for forming and preventing fat approach, and for simple obesity crowd, scientific and reasonable formula provides one kind
Raw material diversification, the significant health food of effect of weight reducing.
In order to achieve the above objectives, the embodiment of the present invention adopts the following technical scheme that
A kind of Traditional Chinese medicine compound health food with effect of weight reducing, the Traditional Chinese medicine compound health food with effect of weight reducing is with Fu
Siberian cocklebur, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed, rhizoma alismatis are Effect raw material, the weight of the Effect raw material
Percentage are as follows: Poria cocos 12-25%, radish seed 10-20%, hawthorn 5-15%, lotus leaf 5-15%, ginger 1-10%, jujube 1-10%, coix lacryma-jobi
The summation of benevolence 12-25%, cassia seed 5-20%, rhizoma alismatis 1-12%, the weight percent of the Effect raw material are no more than 100%.
Further, the Traditional Chinese medicine compound health food for having effect of weight reducing further includes auxiliary material, and the auxiliary material is dextrin, white
Granulated sugar, Aspartame and citric acid.
Further, the weight percent of the Effect raw material are as follows: Poria cocos 20%, radish seed 12.5%, hawthorn 10%, lotus leaf
13.75%, ginger 5%, jujube 5%, semen coicis 20%, cassia seed 7.5%, rhizoma alismatis 6.25%.
Further, the auxiliary material is dextrin, white granulated sugar, Aspartame and citric acid, is counted in mass ratio, functional component is total
Amount: auxiliary material=(2~8): (8~2).
Further, the Traditional Chinese medicine compound health food with effect of weight reducing is that granule, tablet or health food can
With other any dosage forms of receiving.
Further, the Traditional Chinese medicine compound health food with effect of weight reducing is granule.
A kind of preparation method of the Traditional Chinese medicine compound health food with effect of weight reducing, the Chinese medicine with effect of weight reducing are multiple
The preparation method of square health food is used to prepare the Traditional Chinese medicine compound health food with effect of weight reducing, and the preparation method includes:
Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed and rhizoma alismatis are extracted according to the following steps:
(a) the above raw material is taken according to mass ratio, cleans, dries；
(b) by above-mentioned medicine materical crude slice, with distilled water refluxing extraction, solid-liquid ratio 1:10-1:15 is extracted 3 times, preceding 1 hour each twice, third
Secondary 2 hours, merge No. 3 extracting solutions, filters, take supernatant spare；
(c) for supernatant under room temperature 20-25 temperature, 100,000 grades of clean environments, vacuum-concentrcted to specific gravity is 1.08-1.5 liquid
Shape, concentration pressure are -0.06 ~ -0.09Mpa, 60 degree of temperature；
(d) concentrate is spray-dried, is crossed sieve (80-100 mesh), it is spare；
(e) after above-mentioned raw materials extract, auxiliary material dextrin, white granulated sugar, Aspartame and citric acid is added, is uniformly mixed, particle is made
Agent finished product.
Further, the preparation method further include:
1) resulting material in claim 7 will be prepared to mix with magnesium stearate, the V-Mixer of VGH-500 is added to, mixes
30~40 min；ZP-17 tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
2) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min；
3) pack: the finished product after coating obtains finished tablet after being put into racking machine packing, packaging.
As the present invention further scheme: health food of the invention can be any health food that can be used as
Dosage form, these dosage forms include: capsule, tablet, granule, pulvis, pill, paste, liquid dosage form, ordinary food form.
As further scheme of the invention: the health food for weight-reducing is it is characterized by: the dosage form is
Granula or tablet.
Health food of the invention can contain the acceptable auxiliary material of health food, wherein Poria cocos, radish as needed
Son, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed, rhizoma alismatis are shared in the formulation as health food Effect raw material
Weight percent can be 0.1-99.9%, remaining is the acceptable auxiliary material of health food.Health food of the invention, with unit
Dosage form exists, and the unit dosage form refers to the unit of preparation, and such as every of tablet, every capsule of capsule is taken orally
Every bottle of liquid, every bag etc. of granule.
Of the invention formula is scientific and reasonable, and major ingredient is pure Chinese medicine, and primary efficacy is as follows:
Poria cocos: slightly sweet flavor, mild-natured, being used as medicine has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, invigorating the spleen calming heart, increases potassium, sodium etc. in urine
The discharge of electrolyte can quickly remove human internal environment's metabolin, enhance autonomous reparation disorder microenvironment ability, adjuvant treatment
Central obesity effectively prevents the generation of nutrition and metabolism class disease；
Radish seed: regulating spleen and stomach, tonifying Qi resolving sputum, moisturizes the skin promoting digestion and removing indigestion；
Cassia seed: sweet in flavor, cold nature, there is relax bowel and defecation, clear liver and improve vision, reduce by three height and other effects；
Semen coicis: cool in nature, slightly sweet flavor has inducing diuresis for removing edema, invigorating spleen to remove dampness, heat-clearing toxin expelling and other effects；
Lotus leaf: having excreting dampness detumescence, reducing blood lipid, cholesterol, promotes human metabolism, and main chemical compositions have lotus leaf biological
Alkali, lotus flavone have the function of reducing triglyceride and cholesterol level in serum；
Hawthorn: making medicinal, slightly warm in nature with fruit, sour, enter taste warp, has and changes product and help digestion, dissipate that stasis of blood row is stagnant, promotes gastric juice point
It secretes, promote the effect of digestion, lipolysis；
Ginger: taking fresh rhizome, and slightly warm in nature, acrid flavour are the pungent stomachic tonic of armaticity, there is Energy benefit taste, stopping nausea and vomiting by lowering the adverse flow of QI, cough-relieving to dispel
Phlegm and other effects；Curcumin has the function of inhibiting PECTORAL LIMB SKELETON proliferation and differentiation；
Jujube: the nutritional ingredients such as carrotene, B family vitamin, vitamin C and calcium, phosphorus, iron are rich in.With returns spleen stomach meridian, mend
Middle QI invigorating, nourishing blood and tranquilization, mediation property of medicine and other effects.Contained cyclic adenosine monophosphate, be human body cell energetic supersession must be at
Point, muscular strength can be enhanced, fatigue is eliminated, expansion blood vessel, improve myocardial nutrition, have good work to prevention and treatment disease of cardiovascular system
With；
Rhizoma alismatis: slightly sweet flavor, it is cold in nature, return kidney bladder meridian, have clearing damp and promoting diuresis, expel the heat-evil the effect for the treatment of stranguria, can reducing blood lipid, blood glucose, benefit
Urinate liver protection.
Health food of the present invention have it is following the utility model has the advantages that
1, the present invention provides scientific component compatibility is carried out by nine kinds of pure traditional Chinese medicine raw materials, extraction wherein functional component is taken water as a solvent
Made of a kind of Chinese medicine compound prescription slimming health food, used raw material meet the regulation of the Pharmacopoeia of the People's Republic of China,
Safety is without side-effects；
2, by traditional chinese medicine concept combination modern science and technology extraction process, by function of spleen and stomach regulating transporting, relax bowel and defecation, QI invigorating lipid-loweringing,
The functions such as clearing damp and promoting diuresis inhibit PECTORAL LIMB SKELETON proliferation and differentiation, fat absorption and synthesis in combination with partial efficacy raw material, increase
Add the approach such as the consumption of human body energy, comprehensive raising human body basal metabolic rate improves the comprehensively regulating technical ability of itself, stimulates intestines
It wriggles, reduces blood lipid, cholesterol, reduce the deposition of body fat, effectively solve the metabolism that existing quick weight-lossing easily causes
The symptoms such as irregular, resistance is poor, the five internal organs dysfunction of organ.
3, animal experiments prove that, the present invention is safe and nontoxic, not anorexia diarrhea, lowers weight and does not reduce physical strength, thus
Achieve the effect that healthy fat reducing.
Specific embodiment
Technical solution in the embodiment of the present invention is described in detail below.
Embodiment 1: the preparation of health food granule of the present invention.
Select composition of raw materials: Poria cocos 20%, radish seed 12.5%, hawthorn 10%, lotus leaf 13.75%, ginger 5%, jujube 5%, the heart of a lotus seed
The seed of jog's tears 20%, cassia seed 7.5%, rhizoma alismatis 6.25%.The Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, Cassia
Son and rhizoma alismatis extract according to the following steps:
(1) the above raw material (according to mass ratio) is taken, cleans, dry；
(2) by above-mentioned medicine materical crude slice, with distilled water refluxing extraction, solid-liquid ratio 1:10-1:15 is extracted 3 times, preceding 1 hour each twice, third
Secondary 2 hours.Merge No. 3 extracting solutions, filters, take supernatant spare；
(3) supernatant is crossed in room temperature 20-25, under 100,000 grades of clean environments, and vacuum-concentrcted to specific gravity is 1.08-1.5 liquid
Shape, concentration pressure are -0.06 ~ -0.09Mpa, 60 degree of temperature；
(4) concentrate is spray-dried, is crossed sieve (80-100 mesh), it is spare；
After above-mentioned raw materials extract, auxiliary material dextrin, sugar, Aspartame and citric acid is added, is uniformly mixed, granule finished product is made.
Embodiment 2:
Selection composition of raw materials: Poria cocos 15%, radish seed 15%, hawthorn 12%, lotus leaf 12%, ginger 5%, jujube 5%, semen coicis 15%,
Cassia seed 15%, rhizoma alismatis 6%.The Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed and rhizoma alismatis are by real
1 step of example is applied to extract.
Embodiment 3:
Selection composition of raw materials: Poria cocos 15%, radish seed 15%, hawthorn 12%, lotus leaf 12%, ginger 5%, jujube 5%, semen coicis 15%,
Cassia seed 15%, rhizoma alismatis 6%.The Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed and rhizoma alismatis are by real
It applies after 1 step of example extracts, prepares tablet according to the following steps:
1) resulting material is mixed with magnesium stearate, is added to the V-Mixer of VGH-500, mix 30~40 min；ZP-17
Number tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
2) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min.
3) pack: the finished product after coating obtains finished tablet after being put into racking machine packing, packaging.
Subordinate list 1:
| NG | MG | PG | FLG | FHG | |
| Food ration (g/ pcs/day) | 20.2 ±0.89 | 21.5 ±1.11 | 20.1 ±0.92 | 21.4 ±0.85 | 21.3 ±0.94 |
| Weight (g) before testing | 91.2 ±1.32 | 90.7 ±1.32 | 90.5 ±1.32 | 90.8 ±1.32 | 90.6 ±1.32 |
| Weight (g) after test | 284.5 ±7.36 | 346.8 ±8.17 | 310.5±6.94 | 337.2 ±7.49 | 332.8 8.49 |
| Body weight evolution (g) | 193.3±6.38 | 256.1±9.28 | 220±7.25 | 246.4±9.25 | 242.2±7.35 |
Subordinate list 1 is invention formulation to animal effect of weight reducing verification test result.
The male rat of health passes through continuous eight weeks nutrition purposes, especially for feeding animals high lipid foods, builds auxotype obese model, gives simultaneously
Give slimming preparation (being prepared through embodiment 2), test normal group of component (NG), model control group (MG), positive controls (PG, in
Logical board mountain is ground to determine L-carnitine capsule) and low dosage, high dose experimental group (FLG, FHG are prepared through embodiment 2).It weighs weekly
The weight of animals records food ration, and in the 9th week execution animal, takes blood and liver organization and attached adipose tissue, calculate each group
The variation of rat administration front and back weight multiplying power and food ration.
Experiment shows: compared with model group, low, high dose group animal ingestion amount without significant change, but body weight evolution and
Total weight has different degrees of decline, and wherein high dose group has significant difference (P < 0.05).Confirm that high dose group can be reduced
The weight of animals shows it with certain effect of weight reducing.
Subordinate list 2:
Subordinate list 2 is the oral safety experiment testing result of invention formulation animal acute toxicity
Pass through intragastric administration on mice acute toxicity testing (maximum tolerance measurement Law): screening male and female mouse each 10, with LD50 > 20g/kg
The oral stomach-filling of dosage, observe 14 days, active animal is normal during experiment, Normal-weight increase, have no adverse reaction, animal dead
Rate is 0%.Tested material is all larger than the mouse of 20.0g/kg, root to the oral acute toxicity (MTD) of the mouse of two kinds of genders
It is classified according to acute toxicity, it was demonstrated that this product belongs to nontoxic grade, meets " Biological evaluation " requirement.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (6)
1. a kind of Traditional Chinese medicine compound health food with effect of weight reducing, which is characterized in that the Chinese medicine with effect of weight reducing is multiple
Square health food is described using Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed, rhizoma alismatis as Effect raw material
The weight percent of Effect raw material are as follows: Poria cocos 12-25%, radish seed 10-20%, hawthorn 5-15%, lotus leaf 5-15%, ginger 1-10%,
Jujube 1-10%, semen coicis 12-25%, cassia seed 5-20%, rhizoma alismatis 1-12%, the summation of the weight percent of the Effect raw material is not
More than 100%.
2. the Traditional Chinese medicine compound health food according to claim 1 with effect of weight reducing, which is characterized in that described to have weight-reducing
The Traditional Chinese medicine compound health food of effect further includes auxiliary material, and the auxiliary material is dextrin, white granulated sugar, Aspartame and citric acid.
3. the Traditional Chinese medicine compound health food according to claim 1 or 2 with effect of weight reducing, which is characterized in that the function
Imitate the weight percent of raw material are as follows: Poria cocos 20%, radish seed 12.5%, hawthorn 10%, lotus leaf 13.75%, ginger 5%, jujube 5%, the heart of a lotus seed
The seed of jog's tears 20%, cassia seed 7.5%, rhizoma alismatis 6.25%.
4. the Traditional Chinese medicine compound health food according to claim 2 with effect of weight reducing, which is characterized in that the auxiliary material
It for dextrin, white granulated sugar, Aspartame and citric acid, counts in mass ratio, functional component total amount: auxiliary material=(2~8): (8~2).
5. the Traditional Chinese medicine compound health food according to claim 1 or 2 with effect of weight reducing, which is characterized in that the tool
The Traditional Chinese medicine compound health food of effect of weight reducing is granule, tablet or the other any dosage forms of health food acceptable
Traditional Chinese medicine compound health food according to claim 5 with effect of weight reducing, which is characterized in that described that there is weight-reducing
The Traditional Chinese medicine compound health food of effect is granule
A kind of preparation method of the Traditional Chinese medicine compound health food with effect of weight reducing, which is characterized in that described that there is effect of weight reducing
Traditional Chinese medicine compound health food preparation method be used to prepare as it is according to any one of claims 1 to 6 have effect of weight reducing
Traditional Chinese medicine compound health food, the preparation method includes:
Poria cocos, radish seed, hawthorn, lotus leaf, ginger, jujube, semen coicis, cassia seed and rhizoma alismatis are extracted according to the following steps:
(a) the above raw material is taken according to mass ratio, cleans, dries；
(b) by above-mentioned medicine materical crude slice, with distilled water refluxing extraction, solid-liquid ratio 1:10-1:15 is extracted 3 times, preceding 1 hour each twice, third
Secondary 2 hours, merge No. 3 extracting solutions, filters, take supernatant spare；
(c) for supernatant under room temperature 20-25 temperature, 100,000 grades of clean environments, vacuum-concentrcted to specific gravity is 1.08-1.5 liquid
Shape, concentration pressure are -0.06 ~ -0.09Mpa, 60 degree of temperature；
(d) concentrate is spray-dried, is crossed sieve (80-100 mesh), it is spare；
(e) after above-mentioned raw materials extract, auxiliary material dextrin, white granulated sugar, Aspartame and citric acid is added, is uniformly mixed, particle is made
Agent finished product.
6. the preparation method of the Traditional Chinese medicine compound health food according to claim 7 with effect of weight reducing, which is characterized in that
The preparation method further include:
1) resulting material in claim 7 will be prepared to mix with magnesium stearate, the V-Mixer of VGH-500 is added to, mixes
30~40 min；ZP-17 tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
2) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min；
3) pack: the finished product after coating obtains finished tablet after being put into racking machine packing, packaging.
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Address after: 710042 room 112, floor 1, building A2, standard workshop community, Xi'an Textile Industrial Park, Baqiao District, Xi'an City, Shaanxi Province Applicant after: Shaanxi bairuiheng Health Technology Co.,Ltd. Address before: 523808 room 10, 1st floor, building 1, Dongguan Taiwan Biotechnology cooperation center, No.1 Taoyuan Road, Taiwan hi tech park, Songshanhu hi tech Industrial Development Zone, Dongguan City, Guangdong Province Applicant before: DONGGUAN NATURAL SALUTEM HEALTH TECHNOLOGY CO.,LTD. |
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Application publication date: 20190402 |