CN105999212A - Composition having alcohol effect dispelling effect and preparation method and application thereof - Google Patents
Composition having alcohol effect dispelling effect and preparation method and application thereof Download PDFInfo
- Publication number
- CN105999212A CN105999212A CN201610319897.3A CN201610319897A CN105999212A CN 105999212 A CN105999212 A CN 105999212A CN 201610319897 A CN201610319897 A CN 201610319897A CN 105999212 A CN105999212 A CN 105999212A
- Authority
- CN
- China
- Prior art keywords
- compositions
- radix
- preparation
- paeoniae alba
- rhizoma atractylodis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 86
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 81
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 230000000694 effects Effects 0.000 title abstract description 24
- 102000015636 Oligopeptides Human genes 0.000 claims abstract description 37
- 108010038807 Oligopeptides Proteins 0.000 claims abstract description 37
- 240000008042 Zea mays Species 0.000 claims abstract description 34
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 34
- 244000010000 Hovenia dulcis Species 0.000 claims abstract description 33
- 235000008584 Hovenia dulcis Nutrition 0.000 claims abstract description 33
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 17
- 238000000605 extraction Methods 0.000 claims abstract description 9
- 238000003809 water extraction Methods 0.000 claims abstract description 6
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 31
- 235000013399 edible fruits Nutrition 0.000 claims description 31
- 235000009973 maize Nutrition 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 230000036541 health Effects 0.000 claims description 12
- 235000013402 health food Nutrition 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 230000000996 additive effect Effects 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 244000202052 Poncirus trifoliata Species 0.000 claims description 2
- 235000000404 Poncirus trifoliata Nutrition 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 8
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract description 3
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract description 3
- 235000005822 corn Nutrition 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 241000132012 Atractylodes Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 32
- 241000699670 Mus sp. Species 0.000 description 31
- 210000004185 liver Anatomy 0.000 description 28
- 238000012360 testing method Methods 0.000 description 25
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- 238000003304 gavage Methods 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- 208000007848 Alcoholism Diseases 0.000 description 8
- 201000007930 alcohol dependence Diseases 0.000 description 8
- 206010003084 Areflexia Diseases 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 230000028527 righting reflex Effects 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 5
- 231100000753 hepatic injury Toxicity 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000010171 animal model Methods 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 206010043458 Thirst Diseases 0.000 description 3
- -1 antibacterium Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000004973 motor coordination Effects 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 206010003591 Ataxia Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 244000236658 Paeonia lactiflora Species 0.000 description 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000001977 ataxic effect Effects 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 231100000234 hepatic damage Toxicity 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000008818 liver damage Effects 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000037323 metabolic rate Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001533134 Hovenia acerba Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of health-care foods and particularly discloses a composition and a preparation method and application thereof. The composition is prepared from raw materials including radix puerariae, hovenia dulcis thunb, salvia miltiorrhiza, bighead atractylodes rhizomes, radix paeoniae alba and corn oligopeptide, the components are reasonable in composition and are used in a matched mode, and the heath-care function of an alcohol effect dispelling effect is achieved through multiple ways and multiple levels. According to the preparation method of the composition, the radix puerariae, the hovenia dulcis thunb, the salvia miltiorrhiza, bighead atractylodes rhizomes and the radix paeoniae alba are subjected to water extraction or alcohol extraction, and then the extract is mixed with the corn oligopeptide for preparation, active ingredients of the raw materials are retained to the greatest degree, and the prepared composition has the remarkable alcohol effect dispelling effect, meanwhile is simple in operation and is suitable for industrial production.
Description
Technical field
The present invention relates to field of health care food, being specifically related to a kind of is the tool that primary raw material is made by Chinese herbal medicine
There are the compositions of antialcoholism action, health food and preparation method thereof and purposes.
Background technology
Liver is positioned at abdominal part upper right side, carries the critical function sustained life.It is also maximum in human body
Internal organs.The major function of liver be secretion of bile, storage glycogen, regulation protein, fat and
The metabolism etc. of carbohydrate.Removing toxic substances organ maximum in liver or human body, the poison of internal generation
Thing, refuse, the poisonous substance eaten into, the medicine damaging liver etc. also must rely on liver detoxification.Liver
Decompose the noxious substance manufactured by intestinal absorption or other parts of health, then divide with the form of innocuous substance
Secrete bile or blood excretes then.Liver also has hemopoietic and Blood clotting modern job personage to pursue
Have a successful career, the most generally have that heavy traffic, rhythm of life be fast, the erratic problem of diet.In China,
The crowd of sub-health state is about 58.18%, and wherein hepar damnification number reaches 1.3 hundred million people, owing to liver damages
Sick and wounded disease causes nearly 500,000 people of number of death.
The reason causing hepatic injury has a lot.Research shows that multi-medicament can cause hepatic injury, such as antitumor
Chemotherapeutic, antitubercular agent, antipyretic analgesic, immunosuppressant, hypoglycemic medicine, antibacterium, anti-
Fungus and antiviral agents etc..Other appetrol the most often cause hepatic injury.Many liver diseases also can
Cause hepatic injury, such as hepatitis, hepatocarcinoma, liver cirrhosis, the early stage of the hepatopathys such as fatty liver, often appear as liver
Damage.Heart failure when some biliary tract, heart disease, heating etc. disease, all can cause for the moment
Property hepatic injury.Drink the most in a large number, some food edible also can cause liver function injury.And it is medium-term and long-term
Drink and liver can be allowed to can't bear the heavy load, become alcoholic liver in the course of time.If not being controlled by, wine also can be developed into
Essence hepatitis, alcoholic cirrhosis, even hepatocarcinoma.
The traditional Chinese medical science is thought: liver is one of the five internal organs, occupy right flank portion, is that body weight for humans is wanted and the internal organs of maximum,
Its yin-yang attribute is the yang aspect of yin, also known as the moon of fainting.Liver has to rise and sends out, and happiness bar reaches, and dislikes depression, body cloudy and
By sun characteristic.Its function is main catharsis, main store blood, main muscle China pawl, has one's ideas straightened out in mesh, wants the exterior and the interior with gallbladder.
Additionally, the most main Tibetan soul, the effect of department's reproduction.Liver comes to harm and can have a strong impact on health.Therefore, support
Protecting liver the most slowly becomes the pith of health care.
Data shows, China's liver-protection health-care product market marketing scale in 2004 has reached 28.7 hundred million yuan, 2005
Annual sales amount is 31.2 hundred million yuan, the sustained, stable growth of hepatoprotective market be behind people increasingly pay close attention to liver be good for
Kang Wenti.At present, market has existed different types of relieving alcoholism and protecting the liver product, but effect has been not very
Substantially.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of compositions with antialcoholism action and preparation thereof
Method and purposes.Compositions of the present invention various composition reasonable formula, cooperation share, by multiple way
Footpath, reach the health care of relieving alcoholism and protecting the liver at many levels.
For realizing the purpose of the present invention, the present invention adopts the following technical scheme that
A kind of compositions, is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 2-8, Radix Salviae Miltiorrhizae 2-8, Rhizoma Atractylodis Macrocephalae 2-4, Radix Paeoniae Alba 2-4, maize oligopeptide 0.5-1.4.
Wherein, Radix Puerariae, for the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.In "
China's people's republic pharmacopeia " to record its property sweet, pungent, cool.Effect is expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, thoroughly
Rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication, consumption 10-15g.It is clinically used for fever caused by exogenous pathogens headache, item
Stiffback pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels, dizziness and headache, apoplectic hemiplegia, the thoracic obstruction
Pained, damage of the spleen and stomach caused by alcoholism.
Japanese raisintree fruit, for the dry mature seed of Rhamnaceae Poncirus plant trifoliate orange Hovenia acerba Lindl..
It is sweet, sour that " Sichuan Province's Chinese crude drug standard " records its nature and flavor, flat.Merit be effect quench the thirst relieving restlessness, alcoholic intoxication,
Profit stool, urine, consumption 9-15g.Clinical excessive thirst vomiting, alcoholism, cramp and pain in the lower abdomen, hematodiarrhoea.
Radix Salviae Miltiorrhizae, for dry root and rhizome, its property of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge.
Bitter in the mouth, cold nature, GUIXIN, Liver Channel.Effect is blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood
Eliminating carbuncle, consumption 10-15g.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass accumulation, pyretic arthralgia pain, vexed
Sleeplessness, menoxenia, dysmenorrhea amenorrhea, skin ulcer swell and ache.
The Rhizoma Atractylodis Macrocephalae, for the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Its
Bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Effect be invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive,
Consumption 6-12g.Have loose bowels for spleen lack of appetite, abdominal distention, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
The Radix Paeoniae Alba, for the dry root of ranunculaceae plant Radix Paeoniae PaecwiaZarti/ZoraPall.." the China people are altogether
With state's pharmacopeia " record its bitter in the mouth, acid, cold nature, return liver, spleen channel.Effect is nourishing blood for regulating menstruation, yin fluid astringing
Hidroschesis, easing the affected liver to relieve pain, suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain,
Stomachache, limb pain twin, headache dizziness, consumption 6-15g.
Maize oligopeptide, Latin entitled Corn oligopeptides powder, it is with zein
Powder is raw material, through sizing mixing, protease hydrolyzed, separate, filter, the technique such as spray drying produces.
Semen Maydis Toplink promotes the function of detoxification of liver, reduces the toxic and harmful substance damage to liver.Because of it
Containing a high proportion of alanine and leucine, there is sobering-up functions.
Radix Puerariae alcoholic intoxication in compositions of the present invention, only excessive thirst, Japanese raisintree fruit disappears damp and hot, diuresis, red
Ginseng blood circulation promoting and blood stasis dispelling, the Radix Paeoniae Alba nourishes blood yin fluid astringing, Rhizoma Atractylodis Macrocephalae invigorating middle warmer spleen invigorating.All medicines share, and play sobering up, reducing fever altogether, reason
The effect of controlled atmosphere blood；Separately it is aided with functional factor-maize oligopeptide, the stomach absorption to ethanol can be suppressed, promote wine
The metabolism of essence and discharge, alleviate burden of liver.Various composition reasonable formula, cooperation share, by multiple
Approach, reach the health care of effects of relieving alcoholism and protecting liver at many levels.
Compositions of the present invention is raw materials used the most nontoxic, is eaten for a long time dependency little, and cheap,
It is suitable for ordinary consumer to eat, there is wide market prospect.
In some embodiments that the present invention provides, described compositions is by following components in parts by weight system
For forming:
Radix Puerariae 10, Japanese raisintree fruit 2-8, Radix Salviae Miltiorrhizae 2-8, Rhizoma Atractylodis Macrocephalae 2-4, Radix Paeoniae Alba 2-4, maize oligopeptide 0.5-1.4.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 5-7, Radix Salviae Miltiorrhizae 5-7, Rhizoma Atractylodis Macrocephalae 3-4, Radix Paeoniae Alba 3-4, maize oligopeptide 1-1.4.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 2, Radix Salviae Miltiorrhizae 2, the Rhizoma Atractylodis Macrocephalae 2, the Radix Paeoniae Alba 2, maize oligopeptide 0.5.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 8, Radix Salviae Miltiorrhizae 8, the Rhizoma Atractylodis Macrocephalae 4, the Radix Paeoniae Alba 4, maize oligopeptide 1.4.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 2, Radix Salviae Miltiorrhizae 8, the Rhizoma Atractylodis Macrocephalae 2, the Radix Paeoniae Alba 4, maize oligopeptide 1.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 5, Radix Salviae Miltiorrhizae 5, the Rhizoma Atractylodis Macrocephalae 3, the Radix Paeoniae Alba 3, maize oligopeptide 1.4.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 7, Radix Salviae Miltiorrhizae 7, the Rhizoma Atractylodis Macrocephalae 4, the Radix Paeoniae Alba 3, maize oligopeptide 1.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 5, Radix Salviae Miltiorrhizae 6, the Rhizoma Atractylodis Macrocephalae 4, the Radix Paeoniae Alba 4, maize oligopeptide 1.2.
In some preferred embodiments, described compositions is prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 6, Radix Salviae Miltiorrhizae 5, the Rhizoma Atractylodis Macrocephalae 3, the Radix Paeoniae Alba 3, maize oligopeptide 1.
Heretofore described Radix Puerariae, Japanese raisintree fruit, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, maize oligopeptide are abilities
Known to field technique personnel, can be commercially available by commercial sources.
Using dosage and the using method of compositions of the present invention depend on factors, including user
Age, body weight, sex, natural health situation, nutriture, the use time, metabolic rate, disease
The journey order of severity and the subjective judgment of diagnosis and treatment doctor.Those skilled in the art is permissible according to above-mentioned factor
It is easily determined by using dosage and the using method of described compositions.The use agent of compositions of the present invention
Amount and using method depend on factors, including age of user, body weight, sex, natural health
Situation, nutriture, use time, metabolic rate, the course of disease order of severity and the subjectivity of diagnosis and treatment doctor
Judge.Those skilled in the art can be easily determined by the use agent of described compositions according to above-mentioned factor
Amount and using method.
Preferably, the taking dose of described compositions 1.8-2.5g/ days, add before drinking and take once.
Present invention also offers the preparation method of described compositions.
The preparation method of a kind of compositions, takes Radix Puerariae, Japanese raisintree fruit, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Semen Maydis low
Poly-peptide water extraction or alcohol extraction obtain extract, then are mixed homogeneously with maize oligopeptide by described extract.
In some embodiments, described in the preparation method of described compositions, water extraction carries for the backflow that adds water
Take, concentrate drying after extracting solution filtration.
In some preferred embodiments, the preparation method of described compositions is: by Radix Puerariae, Japanese raisintree fruit,
Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae and white peony root in certain proportion weigh, and add 10 times amount water for the first time, reflux, extract, 2.0 hours, the
Secondary adds 8 times amount water, reflux, extract, 1.5 hours, extracting solution filtering and concentrating is dried, obtains extract,
Mix with maize oligopeptide again.
In some embodiments, alcohol extraction described in the preparation method of described compositions be taken as add ethanol return
Stream extracts, concentrate drying after extracting solution filtration.
In some preferred embodiments, the preparation method of described compositions is: by Radix Puerariae, Japanese raisintree fruit,
Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae and white peony root in certain proportion weigh, and add 10 times amount 60% ethanol for the first time, and reflux, extract, 2.0 is little
Time, second time adds 8 times amount 60% ethanol, reflux, extract, 1.5 hours, extracting solution filtering and concentrating is dried,
Obtain extract, then mix with maize oligopeptide.
In a specific embodiment, the present invention is tested by sobering-up functions, anti-drunk function is tested and right
Gavage the dispelling effects of alcohol affecting experimental observation compositions of the present invention of the ethanol mouse movement coordination ability,
Result shows that compositions of the present invention can significantly extend the time for falling asleep of alcohol induced mice sleep, aobvious
Write and extend the drunk incubation period (time for falling asleep) that ethanol causes, increase the mice tolerance to ethanol.
Compositions the most of the present invention has remarkable result to improving the motor coordination obstacle that ethanol causes.
Therefore, present invention also offers described compositions in preparation has the health food of antialcoholism action
Application.
Compositions of the present invention can be added system according to the demand of different users by those skilled in the art
Additive conventional in various bromatologies required during standby different dosage form, such as disintegrating agent, lubricant, emulsifying
Agent, binding agent etc., with conventional formulation method, in the addition bromatology that conventional machining is direct or indirect
Acceptable additive makes conventional health food, as capsule, tablet, pill, oral liquid, powder,
Granule, powder etc..
Therefore, present invention also offers a kind of health food, including the compositions of the present invention of effective dose
The acceptable additive with in bromatology.
Preferably, described in described health food, compositions accounts for the 5wt%-18wt% of described health product.
Preferably, described health food is oral liquid, capsule, tablet, powder or granule.
Compositions of the present invention selects Radix Puerariae, Japanese raisintree fruit, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, maize oligopeptide
Making for raw material, Radix Puerariae alcoholic intoxication, only excessive thirst, Japanese raisintree fruit disappears damp and hot, diuresis, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling,
The Radix Paeoniae Alba is nourished blood yin fluid astringing, Rhizoma Atractylodis Macrocephalae invigorating middle warmer spleen invigorating.All medicines share, and play sobering up, reducing fever altogether, the effect of regulating qi and blood；
Separately it is aided with functional factor-maize oligopeptide, the stomach absorption to ethanol can be suppressed, promote metabolism and the row of ethanol
Go out, alleviate burden of liver.Various composition reasonable formula, cooperation share, by number of ways, at many levels
Reach the health care of effects of relieving alcoholism and protecting liver.The preparation method of compositions of the present invention takes Radix Puerariae, trifoliate orange
Son, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba water extraction or alcohol extraction are mixed to prepare with maize oligopeptide, at utmost again
The effective ingredient remaining each raw material, the compositions effects of relieving alcoholism and protecting liver effect prepared is notable, with
Time simple to operate, be suitable for industrialized production.Compositions of the present invention can significantly extend alcohol induced
The time for falling asleep of mice sleep, the drunk incubation period (time for falling asleep) that notable prolongation ethanol causes, increases
The mice tolerance to ethanol.Compositions the most of the present invention is to improving the motor coordination that ethanol causes
Obstacle has remarkable result.Show that compositions of the present invention can reach the health care of relieving alcoholism and protecting the liver.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than all wholely
Embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creativeness
The every other embodiment obtained under work premise, broadly falls into the scope of protection of the invention.
In order to be better understood from the present invention, below in conjunction with specific embodiment, the present invention is described in detail.
As without in feature description above example, each component is commercial goods.If maize oligopeptide is purchased from Guangzhou
You Fang bio tech ltd.
Embodiment 1
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 2, Radix Salviae Miltiorrhizae 2, the Rhizoma Atractylodis Macrocephalae
2, the Radix Paeoniae Alba 2, maize oligopeptide 0.5.
Preparation method: Radix Puerariae, Japanese raisintree fruit, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are put in extraction pot.With 60%
Ethanol extraction 2 times, extracts 10 times amount 60% ethanol adding the total inventory of above-mentioned medical material, backflow for the first time
Extracting 2.0 hours, second time adds 8 times amount 60% alcohol reflux 1.5 hours, has extracted rear drawing liquid,
Filter to receiver through 80 eye mesh screens.
Filtrate being put in vacuum concentrator and concentrate, temperature controls at 60～80 DEG C, and being reduced to relative density is
1.06～1.15 (60 DEG C of surveys), obtain concentrated solution and mix with maize oligopeptide.
Obtain compositions 1.
Embodiment 2
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 8, Radix Salviae Miltiorrhizae 8, the Rhizoma Atractylodis Macrocephalae
4, the Radix Paeoniae Alba 4, maize oligopeptide 1.4.
Preparation method: Radix Puerariae, Japanese raisintree fruit, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are put in extraction pot.Carry with water
Take 2 times, 10 times amount water of the total inventory of above-mentioned medical material of extraction addition for the first time, reflux, extract, 2.0 hours,
Second time adds 8 times amount water reflux, extract, 1.5 hours, has extracted rear drawing liquid, filters to storage through 80 eye mesh screens
In flow container.
Filtrate being put in vacuum concentrator and concentrate, temperature controls at 60～80 DEG C, and being reduced to relative density is
1.06～1.15 (60 DEG C of surveys), obtain concentrated solution and mix with maize oligopeptide.
Obtain compositions 2.
Embodiment 3
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 2, Radix Salviae Miltiorrhizae 8, the Rhizoma Atractylodis Macrocephalae
2, the Radix Paeoniae Alba 4, maize oligopeptide 1.
Preparation method is with embodiment 1.
Obtain compositions 3.
Embodiment 4
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 5, Radix Salviae Miltiorrhizae 5, the Rhizoma Atractylodis Macrocephalae
3, the Radix Paeoniae Alba 3, maize oligopeptide 1.4.
Preparation method is with embodiment 1.
Obtain compositions 4.
Embodiment 5
Formula: be prepared from by the component of following weight parts proportioning: Radix Puerariae 10, Japanese raisintree fruit 7, Radix Salviae Miltiorrhizae 7,
The Rhizoma Atractylodis Macrocephalae 4, the Radix Paeoniae Alba 3, maize oligopeptide 1.
Preparation method is with embodiment 1.
Obtain compositions 5.
Embodiment 6
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 5, Radix Salviae Miltiorrhizae 6, the Rhizoma Atractylodis Macrocephalae
4, the Radix Paeoniae Alba 4, maize oligopeptide 1.2.
Preparation method is with embodiment 2.
Obtain compositions 6.
Embodiment 7
Formula: be prepared from by following components in parts by weight: Radix Puerariae 10, Japanese raisintree fruit 6, Radix Salviae Miltiorrhizae 5, the Rhizoma Atractylodis Macrocephalae
3, the Radix Paeoniae Alba 3, maize oligopeptide 1.
Preparation method is with embodiment 1.
Obtain compositions 7.
Embodiment 8
The compositions obtained by embodiment 1-7, adds pharmaceutically acceptable adjuvant and additive respectively, prepares
Capsule, capsule every 0.4g, containing compositions 5-18wt%.
Embodiment 9
The compositions obtained by embodiment 1-7, adds pharmaceutically acceptable adjuvant and additive respectively, respectively
Prepare oral liquid, tablet, powder and granule.
Comparative example 1
By Radix Puerariae 10g, Radix Salviae Miltiorrhizae 10g, Japanese raisintree fruit 10g, Rhizoma Atractylodis Macrocephalae 5g, Radix Paeoniae Alba 5g, maize oligopeptide 1.5
G forms.
Preparation method, with embodiment 1, obtains contrast groups 1.
Embodiment 10 pharmacodynamic study
The raw material composition and ratio provided according to embodiment 1-7, described in embodiment 1 or embodiment 2
The compositions for preparing of preparation method carry out efficacy validation test, concrete test is as follows:
1. test unit
Pharmaceutical college of Zhongshan University.
2. experiment purpose
The research present composition causes changing of the sleep state after mice drunk and sports coordination ability to ethanol
Kind degree passes judgment on effects of dispelling effects of alcohol and protecting liver.
3. experimental animal
Experimental animal: SPF level male mouse of kunming, body weight 17-22g, by Zhongshan University's experimental animal
The heart provides, production licence number: SCXK (Guangdong) 0011-0029.The animal quality quality certification number: 0098355.
4. the feeding and management of animal
Raising room: Zhongshan University's Experimental Animal Center (school district, north) second floor barrier environment Animal House.Real
Test animal and use credit number: SYXK (Guangdong) 2007-0081.
The illumination of SPF animal housing is sufficient, and heating ventilation and air-conditioning equipment is good, and room temperature controls at 22 DEG C～25 DEG C, wet
Degree 40～70%.Test chamber is the most periodically sterilized.
5. feedstuff
Kind: SPF level rat sterilizing feedstuff, production unit: Guangdong Medical Lab Animal Center,
Address: Huang Qi Poyang road, Nanhai District Foshan City 119, production licence: SCXK (Guangdong) 2008-0002.
Feeding method: freely absorb
Feedstuff conventional nutrients index: through Experimental Animals Supervising Station, Guangdong Prov. (with reference to China's people's republicanism
State's standard GB/T 14924.3-2010) detection, detection frequency: annual twice.
The preservation of feedstuff: in being saved between special feedstuff, holding is ventilated, cleans, is dried
6. drinking water:
Drinking water kind: through 121 DEG C of (1.0kg/cm2), 30min sterilizing high quality water, meet and " drink clean
Water water standard " (CJ94-2005).
Water feeding method: freely absorb through animal drink bottle
7. main agents
Dehydrated alcohol (Guangzhou Chemical Reagent Factory, analytical pure, lot number: 20110601-2).
8. EXPERIMENTAL DESIGN
8.1 animal packets
1) model control group；
2) 7 example composition groups and comparative example group: 10 times of recommendation dose,equivalents of 7 example composition
Group and comparison 10 times recommend dose,equivalent group.
8.2 be administered
Route of administration and selection reason: per os gastric infusion are identical with clinical administration approach.
Administration frequency: be administered once daily, totally 2 weeks.
8.3 dosages calculate:
Animal consumption is that adult's clinic recommends consumption dose,equivalent after body surface area is converted.Dose lonvestion:
DB=dA*RB//RA* (WA/WB) 1/3 (RA, RB Shape Coefficient, WA, WB body weight), people
Body body weight presses 60-70 kilogram, Mouse Weight 0.02 kilogram, mice Shape Coefficient 0.059, Adult Somatotype system
Several 0.1, after conversion, mouse dose is 8.65-9.11 times of human body dose,equivalent, is rounded to 9 times.
The human dose of example composition is 0.4mg/10g/ days (2.4g/60Kg/ days), is scaled little
Mus dosage is 9 × 0.4mg/10g/ days=3.6mg/10g/ days.(the 10 times of recommendations etc. of example composition dosage
Effect dosage): 36mg/10g/ days.
The dosage of comparison is 36mg/10g/ days；
9. experimental technique
9.1 sobering-up functions tests
Mice is divided into 9 groups at random, often group 10.Test fasting in first 12 hours, can't help water.Experiment opening
Begin first to distinguish gavage 50% ethanol solution 0.17mL/10g.After 30min, given the test agent group gavage respectively is each
The given the test agent of dosage, model group gavage equivalent distilled water.Whether mice drunk with righting reflex loss is
Index, will mice dorsad under be placed in cage for animal gently, if face upward pose gesture keep more than 30s, then recognize
For mice righting reflex loss.Record and compare to respectively group mice sleeping duration, mice
Righting reflex loss is to recovering whether the normal time has significant difference, and observes dead mouse in 24h
Number of elements.
9.2 anti-drunk function tests
Mice is divided into 9 groups at random.Test fasting in first 12 hours, can't help water.On-test given the test agent
The given the test agent of the group each dosage of gavage respectively, model control group gavage equivalent distilled water.After 30min, mould
Type matched group, given the test agent group and positive controls mice gavage 50% ethanol solution 0.17mL/10 respectively
g.Mice drunk whether with righting reflex loss as index, will mice dorsad under be placed on gently in cage for animal,
If facing upward pose gesture to keep more than 30s, then it is assumed that mice righting reflex loss.Record compares to after drinking to mice
Time needed for righting reflex loss, mice righting reflex loss are to recovering whether the normal time has significantly
Sex differernce, and observe dead mouse number of elements in 24h.
9.3 impacts (seeking connections with test) on gavaging the ethanol mouse movement coordination ability
Mice seek connections with test: being placed on by mice on vertical wire netting, mice seeks connections with when online record
Between.Observe by test product role of correcting the most ataxic to mice.Acclimatization training is done in trial test.
Mice is the most all grouped, and tests fasting in first 12 hours, can't help water.Give by prescribed dose gavage respectively
Each given the test agent, blank group, model control group gavage equivalent distilled water, difference gavage 50% after 30min
Ethanol solution 0.13mL/10g.Measure respectively to after ethanol 5 minutes and when after 3.5 hours, mice seeks connections with
Between, each dosage of comparative analysis whether had significance by test product role of correcting the most ataxic to mice
Difference.
9.4 statistical disposition
All tables of data are shown as the form of mean ± standard deviation, spss13.0 statistical software, and single factor test variance is divided
Analysis (one-way ANOVA) multiple mean compares the inspection of LSD method, and P < 0.05 is statistically significant.
10. experimental result
10.1 sobering-up functions is tested
Table 1 on gavage ethanol mice relieving alcoholic intoxication impact (N=10)
* represent and compare with model control group, P < 0.05.
Table 1 result shows occur lethargy after mouse gavaging ethanol, and the compositions of embodiment 1-7 all shows
Postpone the effect (difference has significance) of time for falling asleep, show that example composition can significantly extend ethanol
The drunk incubation period (time for falling asleep) caused, increase the mice tolerance to ethanol.Embodiment combines
Thing shows the trend extending the length of one's sleep.
10.2 anti-drunk function is tested
Table 2 on the anti-intoxication impact of mice (N=10)
* represent and compare with model control group, P < 0.05.
Table 2 result shows occur lethargy after mouse gavaging ethanol, and the compositions of embodiment 1-7 shows prolongs
The trend of the long length of one's sleep.
10.3 impacts (seeking connections with test) on gavaging the ethanol mouse movement coordination ability
The table 3 impact (wire netting method seeks connections with test) on gavaging the ethanol mouse movement coordination ability
(N=10, unit: second)
* represent and compare with model control group, P < 0.05.
Table 3 result shows, mouse gavaging ethanol is sports coordination ability decline, embodiment 1-7 after 5 minutes
Compositions group to the mouse movement coordination ability decline have the trend alleviated.After mouse gavaging ethanol 3.5 hours
Sports coordination ability declines, and the mouse movement coordination ability is declined to have and alleviates by the compositions of embodiment 1-7
Trend.Show that sports coordination ability is declined to have by example composition and alleviate trend.
In sum, when compositions of the present invention can significantly extend the sleep of alcohol induced mice sleep
Between, the drunk incubation period (time for falling asleep) that notable prolongation ethanol causes, increase the mice tolerance to ethanol
Ability.Compositions the most of the present invention has remarkable result to improving the motor coordination obstacle that ethanol causes.
Claims (10)
1. a compositions, it is characterised in that be prepared from by following components in parts by weight:
Radix Puerariae 10, Japanese raisintree fruit 2-8, Radix Salviae Miltiorrhizae 2-8, Rhizoma Atractylodis Macrocephalae 2-4, Radix Paeoniae Alba 2-4, maize oligopeptide 0.5-1.4.
Compositions the most according to claim 1, it is characterised in that prepared by following components in parts by weight
Form:
Radix Puerariae 10, Japanese raisintree fruit 5-7, Radix Salviae Miltiorrhizae 5-7, Rhizoma Atractylodis Macrocephalae 3-4, Radix Paeoniae Alba 3-4, maize oligopeptide 1-1.4.
Compositions the most according to claim 2, it is characterised in that prepared by following components in parts by weight
Form:
Radix Puerariae 10, Japanese raisintree fruit 6, Radix Salviae Miltiorrhizae 5, the Rhizoma Atractylodis Macrocephalae 3, the Radix Paeoniae Alba 3, maize oligopeptide 1.
4. the preparation method of compositions described in a claim 1, it is characterised in that take Radix Puerariae, trifoliate orange
Son, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba water extraction or alcohol extraction obtain extract, then by described extract and Semen Maydis
Oligopeptide mix homogeneously.
Preparation scheme the most according to claim 4, it is characterised in that described water extraction is for adding water back
Stream extracts, concentrate drying after extracting solution filtration.
Preparation scheme the most according to claim 4, it is characterised in that described alcohol extraction is taken as adding second
Alcohol reflux extracts, concentrate drying after extracting solution filtration.
7. compositions described in claim 1-3 any one is in preparation has the health food of antialcoholism action
Application.
8. a health food, it is characterised in that include the claim 1-3 any one institute of effective dose
State acceptable additive in compositions and bromatology.
Health food the most according to claim 8, it is characterised in that it is characterized in that, described combination
Thing accounts for the 5wt%-18wt% of described health product.
Health food the most according to claim 8 or claim 9, it is characterised in that it is oral liquid, glue
Wafer, tablet, powder or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610319897.3A CN105999212A (en) | 2016-05-13 | 2016-05-13 | Composition having alcohol effect dispelling effect and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610319897.3A CN105999212A (en) | 2016-05-13 | 2016-05-13 | Composition having alcohol effect dispelling effect and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999212A true CN105999212A (en) | 2016-10-12 |
Family
ID=57099724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610319897.3A Withdrawn CN105999212A (en) | 2016-05-13 | 2016-05-13 | Composition having alcohol effect dispelling effect and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999212A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108208852A (en) * | 2017-12-26 | 2018-06-29 | 安徽中森生物技术有限公司 | A kind of preparation method of corn peptide relieving alcoholism and protecting liver composition |
| CN109432387A (en) * | 2018-12-21 | 2019-03-08 | 陕西师范大学 | It is a kind of with the Chinese medicine-peptide combinations and preparation method thereof for resisting drunk effect |
| CN109432386A (en) * | 2018-11-08 | 2019-03-08 | 武汉森澜生物科技有限公司 | A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof |
| CN114631565A (en) * | 2022-03-28 | 2022-06-17 | 唐建 | Beverage before drinking and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733286A (en) * | 2005-08-19 | 2006-02-15 | 上海中医药大学附属曙光医院 | A kind of compound Chinese medicinal preparation of preventing and treating alcoholic intestinal tract damage and hepatic injury |
| CN101455354A (en) * | 2007-12-14 | 2009-06-17 | 中国科学院微生物研究所 | Natural Juncao liver-nourishing and sobering-up agent |
| CN101513463A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN101618206A (en) * | 2009-07-24 | 2010-01-06 | 南方医科大学 | Composition for sobering up and protecting liver |
| CN101731630A (en) * | 2010-01-22 | 2010-06-16 | 完美（中国）日用品有限公司 | Health-care food with effects of neutralizing effect of alcoholic drinks and protecting liver |
| CN103142812A (en) * | 2013-03-29 | 2013-06-12 | 山东省中医药研究院 | Traditional Chinese medicine for preventing and treating alcoholic liver injury and preparation method of traditional Chinese medicine |
| CN104172159A (en) * | 2014-07-24 | 2014-12-03 | 北京中泰天和科技有限公司 | Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof |
| CN104644915A (en) * | 2015-01-22 | 2015-05-27 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition |
| CN104784295A (en) * | 2015-04-27 | 2015-07-22 | 无限极（中国）有限公司 | Traditional Chinese medicine composition with capabilities of alleviating hangover and protecting liver and preparation method of traditional Chinese medicine composition |
| CN105288170A (en) * | 2015-12-08 | 2016-02-03 | 济南舜祥医药科技有限公司 | Beverage with drink for relieving alcoholic effect and protecting liver |
-
2016
- 2016-05-13 CN CN201610319897.3A patent/CN105999212A/en not_active Withdrawn
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733286A (en) * | 2005-08-19 | 2006-02-15 | 上海中医药大学附属曙光医院 | A kind of compound Chinese medicinal preparation of preventing and treating alcoholic intestinal tract damage and hepatic injury |
| CN101455354A (en) * | 2007-12-14 | 2009-06-17 | 中国科学院微生物研究所 | Natural Juncao liver-nourishing and sobering-up agent |
| CN101513463A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN101618206A (en) * | 2009-07-24 | 2010-01-06 | 南方医科大学 | Composition for sobering up and protecting liver |
| CN101731630A (en) * | 2010-01-22 | 2010-06-16 | 完美（中国）日用品有限公司 | Health-care food with effects of neutralizing effect of alcoholic drinks and protecting liver |
| CN103142812A (en) * | 2013-03-29 | 2013-06-12 | 山东省中医药研究院 | Traditional Chinese medicine for preventing and treating alcoholic liver injury and preparation method of traditional Chinese medicine |
| CN104172159A (en) * | 2014-07-24 | 2014-12-03 | 北京中泰天和科技有限公司 | Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof |
| CN104644915A (en) * | 2015-01-22 | 2015-05-27 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition |
| CN104784295A (en) * | 2015-04-27 | 2015-07-22 | 无限极（中国）有限公司 | Traditional Chinese medicine composition with capabilities of alleviating hangover and protecting liver and preparation method of traditional Chinese medicine composition |
| CN105288170A (en) * | 2015-12-08 | 2016-02-03 | 济南舜祥医药科技有限公司 | Beverage with drink for relieving alcoholic effect and protecting liver |
Non-Patent Citations (1)
| Title |
|---|
| 陈浩凡等: "养肝解酒方解酒功能及对急性肝损伤的保护作用", 《中药材》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108208852A (en) * | 2017-12-26 | 2018-06-29 | 安徽中森生物技术有限公司 | A kind of preparation method of corn peptide relieving alcoholism and protecting liver composition |
| CN109432386A (en) * | 2018-11-08 | 2019-03-08 | 武汉森澜生物科技有限公司 | A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof |
| CN109432387A (en) * | 2018-12-21 | 2019-03-08 | 陕西师范大学 | It is a kind of with the Chinese medicine-peptide combinations and preparation method thereof for resisting drunk effect |
| CN114631565A (en) * | 2022-03-28 | 2022-06-17 | 唐建 | Beverage before drinking and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103734428B (en) | A kind of glossy privet fruit health-care tea improving immunity and preparation method thereof | |
| CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
| KR101787432B1 (en) | Method for manufacturing oriental medicine composition which improves menorrhagia and dysmenorrhea comprising fermented velvet antler and yeast hydrolysate | |
| CN102886038B (en) | Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation | |
| CN104524110A (en) | Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp | |
| CN103520577A (en) | Medicine-and-food dual-purpose preparation for treating pneumoconiosis, clearing away lung-heat and nourishing heart and preparation method for medicine-and-food dual-purpose preparation | |
| CN103734426B (en) | A kind of Fructus Corni health protection tea of improving immunity and preparation method thereof | |
| CN100443109C (en) | Medicament for preventing and treating ageing diseases | |
| CN105999212A (en) | Composition having alcohol effect dispelling effect and preparation method and application thereof | |
| CN111012876A (en) | Product for improving sleep and preparation method and application thereof | |
| CN104206905A (en) | Feed additive for reducing cholesterol content in eggs | |
| CN106177183A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, green tea and Folium Mori | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN104138526A (en) | Granules prepared by combined spicebush roots, dendrobium candidum and ginseng | |
| CN103238757B (en) | Compound feed containing fermented cottonseed meal for chicken for eggs and preparation method thereof | |
| CN106177477A (en) | A kind of health composition for blood sugar lowering, blood fat reducing and blood pressure lowering | |
| CN102266511B (en) | Chewable tablet for removing summer heat and strengthening stomach for children, and preparation method thereof | |
| CN104489172A (en) | Acanthopanax health tea for improving immunity and preparation method thereof | |
| CN101884671B (en) | Food therapy preparation for preventing and treating asthma based on theories of preventive treatment of disease and medicine food homology | |
| CN104206595A (en) | Blood lipid and blood glucose reducing Chinese wolfberry root-bark health care tea and preparation method thereof | |
| CN104161194A (en) | Feed used for reducing content of cholesterol in egg | |
| CN113925172A (en) | Giant salamander peptide nutritional composition suitable for children | |
| CN108186966A (en) | A kind of composition for preventing or improving senile dementia and its application | |
| CN106860814A (en) | A kind of improvement women frequent micturition, health-care food composition of the urinary incontinence and its preparation method and application | |
| CN106822660A (en) | A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |
|
| WW01 | Invention patent application withdrawn after publication |