CN106860814A - A kind of improvement women frequent micturition, health-care food composition of the urinary incontinence and its preparation method and application - Google Patents
A kind of improvement women frequent micturition, health-care food composition of the urinary incontinence and its preparation method and application Download PDFInfo
- Publication number
- CN106860814A CN106860814A CN201710062636.2A CN201710062636A CN106860814A CN 106860814 A CN106860814 A CN 106860814A CN 201710062636 A CN201710062636 A CN 201710062636A CN 106860814 A CN106860814 A CN 106860814A
- Authority
- CN
- China
- Prior art keywords
- pumpkin
- pepo
- oil
- water extract
- health
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000027939 micturition Effects 0.000 title claims abstract description 33
- 206010046543 Urinary incontinence Diseases 0.000 title claims abstract description 23
- 235000013305 food Nutrition 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 230000006872 improvement Effects 0.000 title abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 98
- 235000009854 Cucurbita moschata Nutrition 0.000 claims abstract description 64
- 239000003921 oil Substances 0.000 claims abstract description 63
- 235000019198 oils Nutrition 0.000 claims abstract description 63
- 235000000832 Ayote Nutrition 0.000 claims abstract description 62
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims abstract description 62
- 235000015136 pumpkin Nutrition 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 40
- 240000001980 Cucurbita pepo Species 0.000 claims abstract description 39
- 241000237502 Ostreidae Species 0.000 claims abstract description 31
- 235000020636 oyster Nutrition 0.000 claims abstract description 30
- 239000008171 pumpkin seed oil Substances 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 22
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 20
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 20
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 20
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 20
- 241000572565 Alpinia oxyphylla Species 0.000 claims abstract description 7
- 238000003809 water extraction Methods 0.000 claims description 24
- 230000001954 sterilising effect Effects 0.000 claims description 17
- 235000009852 Cucurbita pepo Nutrition 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 16
- 241000408747 Lepomis gibbosus Species 0.000 claims description 15
- 235000020236 pumpkin seed Nutrition 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 10
- 238000005469 granulation Methods 0.000 claims description 10
- 230000003179 granulation Effects 0.000 claims description 10
- 235000013402 health food Nutrition 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 25
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract description 2
- 240000004244 Cucurbita moschata Species 0.000 description 40
- 210000002700 urine Anatomy 0.000 description 25
- 239000003814 drug Substances 0.000 description 24
- 210000003734 kidney Anatomy 0.000 description 24
- 210000003932 urinary bladder Anatomy 0.000 description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- 201000010099 disease Diseases 0.000 description 19
- 210000000952 spleen Anatomy 0.000 description 17
- 229940079593 drug Drugs 0.000 description 15
- 208000008967 Enuresis Diseases 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 238000001914 filtration Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 210000003296 saliva Anatomy 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 230000035619 diuresis Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 238000010792 warming Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 206010059013 Nocturnal emission Diseases 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- 210000003708 urethra Anatomy 0.000 description 4
- 206010000060 Abdominal distension Diseases 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 235000014676 Phragmites communis Nutrition 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 229930182558 Sterol Natural products 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000004879 dioscorea Nutrition 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 238000002309 gasification Methods 0.000 description 3
- 230000000422 nocturnal effect Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 206010036067 polydipsia Diseases 0.000 description 3
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 3
- 235000003702 sterols Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 229930003347 Atropine Natural products 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 240000009087 Crescentia cujete Species 0.000 description 2
- 235000005983 Crescentia cujete Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 235000009797 Lagenaria vulgaris Nutrition 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000507 anthelmentic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
- 229960000396 atropine Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- WTQYWNWRJNXDEG-UHFFFAOYSA-N (6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate Chemical compound CN1C(C2)CC(O)C1CC2OC(=O)C(CO)C1=CC=CC=C1 WTQYWNWRJNXDEG-UHFFFAOYSA-N 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 102000040350 B family Human genes 0.000 description 1
- 108091072128 B family Proteins 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010008469 Chest discomfort Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241001522252 Crassostrea rivularis Species 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000219122 Cucurbita Species 0.000 description 1
- 235000009364 Cucurbita pepo var ovifera Nutrition 0.000 description 1
- 244000049043 Cucurbita pepo var. melopepo Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 1
- 208000035126 Facies Diseases 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 240000002045 Guettarda speciosa Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 206010020853 Hypertonic bladder Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 241000366676 Justicia pectoralis Species 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241001523579 Ostrea Species 0.000 description 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241001579678 Panthea coenobita Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000028938 Urination disease Diseases 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- -1 linoleic acid, leukotrienes Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000020629 overactive bladder Diseases 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000008925 spontaneous activity Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 208000022170 stress incontinence Diseases 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of improvement women frequent micturition, the health-care food composition of the urinary incontinence and its preparation method and application, belong to technical field of health care food.Composition of the invention is mainly made up of the material component of following weight portion：0.4~5 part of pumpkin seed oil, 0.4~4 part of pumpkin water extract, 15~30 parts of Chinese yam, 0.6~3 part of water extract of Alpinia oxyphylla Miq, 0.4~5 part of pepo oil, 0.4~5 part of pepo water extract, 0.5~3 part of Radix Angelicae Sinensis water extract, 0.5~2 part of oyster.The present invention is using unique extracting method, and active ingredient utilization rate is high, and the small, effect of waste is good, without any side effects.
Description
Technical field
The present invention relates to a kind of health-care food composition, more particularly to a kind of guarantor for improving women frequent micturition, the urinary incontinence
Health food composition, with and its preparation method and application, belong to technical field of health care food.
Background technology
Aging population is one of significant challenge that international community is faced at present, and it is aged that each state will all respond actively population
Fundamental state policy is included in change.At present, the U.S. 65 years old and above the elderly account for 12.5% or so of national population, and the year two thousand fifty is up to
20.7%, wherein, 85 years old and the above size of population are up to more than 1,800 ten thousand, are nearly 6 times of nineteen ninety-five.2005~the year two thousand thirty,
The aged of European Union's over-65s will increase by 52.3%.According to State Statistics Bureau《National economy and social development in 2015 is united
Meter publication》It has been shown that, 60 one full year of life and the people of above population 222,000,000, account for the 16.1% of total population, 65 one full year of life and above population 14386
Ten thousand people, account for total population 10.5% (one full year of life of China 60 in 2014 and the people of above population 212,420,000, account for the 15.5% of total population, 65
One full year of life and the people of above population 137,550,000, account for total population 10.1%).Geriatric population's quantity increases by 4.7% on a year-on-year basis, with population
The aging and average life span increases, and suffering from urinary system patient will continue to rise.Clinical manifestation is frequent micturition, urgent urination, enuresis nocturna increase,
The symptom doctor trained in Western medicine such as urinary incontinence thinks that women is mainly caused by overactive bladder.These diseases not only make patient bear physiology
On pain and Mental health problem, while also bringing many troubles to its children, or even influence the normal life of whole family.
The generation and excretion of urine play extremely critical effect in body water metabolism equilibrium process is maintained.Bladder is human body
Storage urine and the organ of urination, but the generation and excretion of urine are all necessarily dependent upon the effect of kidney qi.In have a kidney qi evaporate function
Bring into normal play, the promotion of kidney yin kidney yang and regulating and controlling effect are coordinated, and bladder folding degree of having, urine could normally be generated and drained.
The gasification of kidney is normal, then bladder folding is normal, and turbid liquid must be let out, if the gasification of kidney is often, influences the folding of bladder, causes bladder
Folding is unfavorable, and sees the diseases such as oliguria, oedema；Or cause bladder constraint to have no right, and see the diseases such as diuresis, the enuresis.The prosperity and decline of kidney qi, directly
Influence the gasification and folding of bladder.Cause bladder folding unfavorable or cause bladder constraint to be had no right, and see the diseases such as diuresis, the enuresis.
The urinary incontinence is can not independently not flowed out by consciousness control urinary function, urine, and the urinary incontinence is urination disorder disease
The common sympton of trouble, is substantially the performance of bladder storage urine dysfunction, a urinary incontinence not independent disease, but some
Illness involves the result of bladder, urethral function.30% the elderly suffers from the different degrees of urinary incontinence, and has obvious gender gap
Different, women illness rate is higher than male.Elderly woman stress incontinence illness rate is 29.0%, hence it is evident that ill higher than elderly men
Rate 11.9%.Along with the aging of society, frequent micturition, the urinary incontinence have turned into social concern, particularly frequent micturition and urinary incontinence limitation
The sphere of action of patient, significantly reduces their quality of life, and western medicine treatment effect is not good, and recurrence rate is high, and side effect is big,
White elephant is brought to patient.
The function of human internal organ is gradually reduced with advancing age, cause it is a variety of do not accommodate inconvenience, old man's enuresis nocturna
It is exactly wherein more prominent one kind that number is excessive.The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, main water, and have one's ideas straightened out Yu Eryin.Gerontal patient's kidney
Positive virtual loss, the Yang-function insufficiency of kidneyzang, night category is cloudy, then yang-energy virtual loss is more very, it is impossible to admittedly bladder is taken the photograph, so that enuresis nocturna increases.
The present invention studies women frequent micturition, the pathogenesis of the urinary incontinence, selected raw material, using only on the basis of diagnosis and treatment
Extreme pressure is squeezed, extracting method prepares to have improves women frequent micturition, the health food of the urinary incontinence.Health-care food composition of the invention by
Pumpkin seed oil, pumpkin water extract, Chinese yam, water extract of Alpinia oxyphylla Miq, pepo oil, pepo water extract, Radix Angelicae Sinensis
Water extract, the taste of oyster 8 composition.Pepo reducing fever and causing diuresis in side, relieving restlessness are quenched the thirst, moisten the lung and relieve the cough, dispersing swelling and dissipating binds, treat oedema
The disease such as abdominal distension, polydipsia, sore and ephritis, cirrhotic ascites.Pepo as main component, be aided with pumpkin etc. other 7
Taste composition；Pumpkin is sweet, warm in nature, enters spleen, stomach, tonifying middle-Jiao and Qi, anti-inflammatory analgetic；Chinese yam nature and flavor are sweet, flat, nontoxic.Return through is returned
Spleen, lung, kidney channel；Take the photograph saliva with warming spleen and stopping diarrha, warm up kidney contracting urine controlling nocturnal emission with astringent drugs the effect of.Fructus alpiniae oxyphyllae is usually used in deficiency-cold in spleen and stomach, vomiting, lets out
Rush down, crymodynia in abdomen, many salivas of mouth, enuresis with renal asthenia, frequent micturition, pass out semen, gonorrhoea.Oyster controls that urine number is more, little Bian Lin Bi.All medicines are closed
With invigorating Qi and tonifying kidney, dredging collateral contracting spring being played altogether, the effect of improve women frequent micturition, the urinary incontinence.Additionally, the present invention also uses " cold-press "
Process raw material, and press cake is processed further treatment using water extraction mode and obtain active ingredient, make full use of raw material；Extracted
In journey add fructus alpiniae oxyphyllae, Radix Angelicae Sinensis, oyster, fructus alpiniae oxyphyllae have it is warming spleen and stopping diarrha take the photograph saliva, warm up kidney contracting urine controlling nocturnal emission with astringent drugs the effect of.Contain in Radix Angelicae Sinensis
Abundant Zn-ef ficiency, the material such as several amino acids, vitamin contained by oyster.The present invention attempts extracting pumpkin seed oil and water first
Thing is combined the material such as addition Radix Angelicae Sinensis, oyster simultaneously and heightens the effect of a treatment, without any side effects, makes active ingredient utilization rate higher,
The performance of raw material is made full use of, small, effect is wasted good.The present inventor is by experiment again and again, summary and improves,
It is final to determine lower technical scheme, and achieve ideal therapeutic effect.
A kind of possible technical scheme：A kind of improvement women frequent micturition, the health food preparation method of the urinary incontinence.Its feature exists
In：Choosing raw material has 0.4~5 part of pumpkin seed oil, 15~30 parts of Chinese yam, 0.6~3 part of water extract of Alpinia oxyphylla Miq.Processing method：Mountain
Medicine is crushed after taking steam sterilizing, and pumpkin obtains pumpkin seed oil with pepo using direct expression, using water extraction method
Extract fructus alpiniae oxyphyllae active principle.
Shortcoming：1st, direct expression technological operation is simple, production equipment can letter can numerous, production scale flexible in size, be applicable
In the production of each vegetable oil, but to there is oil yield low for milling process, and labour is big, the shortcoming of low production efficiency.2nd, it is single into
The application that the application or 1-2 kind raw materials for dividing are combined, single varieties.
The content of the invention
Improve women frequent micturition, the health-care food composition of the urinary incontinence and its preparation it is an object of the invention to provide a kind of
Methods and applications.
In order to achieve the above object, present invention employs following technological means：
The present invention provides a kind of health-care food composition for improving women frequent micturition, the urinary incontinence, by following parts by weight
Bulk drug be made：0.4~5 part of pumpkin seed oil, 0.4~4 part of pumpkin water extract, 15~30 parts of Chinese yam, fructus alpiniae oxyphyllae water extraction
Take 0.6~3 part of thing, 0.4~5 part of pepo oil, 0.4~5 part of pepo water extract, Radix Angelicae Sinensis water extract 0.5~3
Part, 0.5~2 part of oyster；Preferably, it is made up of the bulk drug of following parts by weight：2.5 parts of pumpkin, pumpkin water extract
2.5 parts, 15 parts of Chinese yam, 1.5 parts of water extract of Alpinia oxyphylla Miq, 2.5 parts of pepo oil, 2.5 parts of pepo water extract, Radix Angelicae Sinensis
1.5 parts of water extract, 1 part of oyster.
Further, the invention provides the preparation method for above-mentioned health-care food composition, comprise the following steps：
(1) sterilize
Chinese yam is carried out into sterilization treatment, be dry, pulverize, sieved, obtain material A, it is standby；
Oyster is carried out into sterilization treatment, be dry, pulverize, sieved, obtain material B, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is extracted oil, and obtains the pumpkin after pumpkin seed oil, i.e. material C, and squeezing
Seedcake, it is standby；
Pepo is peeled off, and takes seed benevolence, by the oil expression of pepo benevolence, obtains pepo oil, i.e. after material D, and squeezing
Cucurbita pepo seedcake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted,
Filtering, concentration is dried, and respectively obtains the water extract of pumpkin, pepo, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae, respectively material E-H, standby
With；
(4) mix
Eight kinds of materials of A-H are weighed according to formula, is well mixed, granulation is obtained final product.
Wherein, it is preferred that sterilization treatment described in step (1) is steam sterilizing treatment；The sieving was 80~100 mesh
Sieve.
Wherein, it is preferred that pumpkin seed extracts oil described in step (2) be to carry out cold press, adjustment oil expression using oil press
Machine press chamber temperature 70 C, pressure 3.5Mpa, rotating speed 36r/min, repeatedly 3~4 times.
Wherein, it is preferred that pepo benevolence is extracted oil described in step (2) be to carry out cold press using oil press, and adjustment is squeezed
80 DEG C of oil machine press chamber temperature, pressure 3.6Mpa, rotating speed 36r/min, repeatedly 3~4 times.
Wherein, it is preferred that the feed liquid weight ratio that water described in step (3) is extracted is 1：10~1：20.
Health-care food composition of the invention can be used to prepare improves women frequent micturition, urinary incontinence health food.
The function of each component is as follows in inventive formulation：
Pumpkin：Pumpkin (cucurbita moschata Duch.), alias pumpkin, meal melon etc. are annual Curcurbitaceaes
Herbaceous plant.The nutritive value of pumpkin is very high, except containing the nutrition such as various free amino acids, carotene, VB, VC, mannitol into
Exceptionally, also containing multiple efficacies composition, domestic more to the research of pumpkin, the research to pumpkin is started late.Pumpkin is
The mature seed of pumpkin, it contains abundant unrighted acid, vitamin, biological flavone, squash polyoses and mineral matter etc., this
A little functional components have extensive and important biological function, with preferably research and application value.Pumpkin seed oil is from complete
The grease extracted in complete ripe pumpkin, in natural bottle green, salubrious non-greasy has a nutty, rich in nutrition content,
It is that can provide one of needed nutrient matter and content nutritional oil higher to human body.Pumpkin seed oil be pumpkin by squeezing or
Extracting method is obtained, wherein containing oleic acid, linoleic acid, leukotrienes, palmitic acid, stearic acid, arachidic acid, watt gram a kind of reed mentioned in ancient books acid, erucic acid etc.
Unrighted acid, total unrighted acid accounts for the 74.9% of fatty acid total amount, and oleic acid therein, linoleic acid content account for pumpkin
The 35%~50% of seed dry weight.With polyunsaturated fatty acid (PUFA) as main component in unrighted acid；In pumpkin seed oil
Also containing abundant vitamin, such as fat-soluble VE also contains a certain amount of phylloquinone-vitamin K；Mineral in pumpkin seed oil
Matter content very abundant, wherein zinc, magnesium, iron, selenium etc. have special biological effectiveness.Especially, plant steroid contained therein
Alcohol, can treat the disease in the urological system symptom of patient BPH, and in traditional medicine, its seed is used as antihelmintic, demulcen, diuresis
Agent and tonic, the plant tea being made of its seed can treat hypertrophy of the prostate.It can be seen that pumpkin is in field of health care food
There is good development prospect.
Pepo：Cucurbita pepo (Cucurbita pepo L.) also known as Cucurbita aurantia Willd.,
Cucurbita melopepo L.Pepo vulgaris Moench.Early in the Christian era century edible cucurbita pepo of existing ancients
Record, from that time, in countries such as China, be just known.Successive dynasties, medicine scholar unanimously generally acknowledged that it has six functionses：
Nourishing beauty, mental-tranquilization, stomach invigorating moistening lung, antibacterial salubrity, relax bowel, profit pressure chest wide.In addition, it may also be used for auxiliary treatment water
Swollen abdominal distension, polydipsia, the disease such as sore and ephritis, cirrhotic ascites.In traditional medicine, its seed be used as antihelmintic, demulcen,
Diuretics and tonic, the plant tea being made of its seed can treat hypertrophy of the prostate.Cucurbita pepo seed is used at present
The example of the treatment disease in the urological system related to benign prostatauxe (BPH).The main component of pepo is plant steroid
Alcohol, reactive compound is Δ 5, Δ 7 and Δ 8- sterols, and wherein Δ 7- sterols are high in cucurbitae semina content, it is considered to be controlled
Treat the key active ingredients in benign prostate hyperplasia, a small amount of Δ 5, Δ 8- sterols similarly exist in cucurbitae semina and
Effect, the carotenoid of high content, polyunsaturated fatty acid and liposoluble vitamin also have certain active function, can treat
The disease in the urological system symptom of patient BPH, there is good development prospect in field of health care food.19 end of the centurys, pepo
Oil just be used to treat urinary tract illness.Zooscopy shows that cucurbita pepo seed water extract may improve the work(of bladder and urethra
Energy.
Chinese yam：It is the dry rhizome of Dioscoreaceae plant Chinese yam (DfcKSCorea opposita Thunb.).Winter cauline leaf
Excavated after withered, cut root head, cleaned, remove crust and fibrous root, dried, practised and claim " hair yam slice "；Or crust is removed, take advantage of fresh-cut
Sheet, dries, referred to as " yam slice "；Also have selection it is loose it is straight dry Chinese yam , Zhi Cheongju water, be dipped into without the dry heart, it is vexed, cut
Neat two ends, are twisted into cylindric with plank, are dried, polishing, are practised and are claimed " light yam ".Nature and flavor：It is sweet, put down.Return through：Returns spleen, lung, kidney channel.
Effect：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band,
Frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea.
Fructus alpiniae oxyphyllae：Fructus alpiniae oxyphyllae is the fruit of zingiberaceous plant intelligence development Alpinia oxyphylla Miq..Between summer, autumn fruit by
It is green to harvest when reddening, dry or low temperature drying.Seed is in irregular oblateness, slightly wane, and diameter about 3mm, surface ash is brown
Color or lark, the outer aril by light brown film quality；Matter is hard, endosperm white.There are special fragrance, taste is pungent, slight bitter.Nature and flavor：Taste
It is pungent, temperature.Return through：Returns spleen, kidney channel.Effect：Warm kidney astringent sperm contracting urine, it is warming spleen and stopping diarrha to take the photograph saliva.For enuresis with renal asthenia, frequent urination is lost
Pure white is turbid, malaria diarrhea, crymodynia in abdomen, many salivas of mouth.Modern pharmacology research fructus alpiniae oxyphyllae contains volatile oil, fructus alpiniae oxyphyllae ketone, dimension
Raw element B1, B2, C, E and several amino acids etc..
Radix Angelicae Sinensis：Radix Angelicae Sinensis is one of the most frequently used Chinese medicine, and Angelica sinensis are worked as from samphire
(Oliv.) dry root of Diels.Its is warm in nature, sweet, pungent.Return liver, the heart, the spleen channel；Lead to replenishing and activating blood, menstruction regulating and pain relieving, ease constipation
Just function；For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, traumatic injury,
The diseases such as ulcer sores, dry constipation of intestines.In addition to tcm prescription formula medication, the Chinese patent drug containing Radix Angelicae Sinensis is planted up to more than 80.Meanwhile, Radix Angelicae Sinensis
Be ministry of Health of China regulation can be used for the raw material of health food, often eaten as invigorant in daily life.
Oyster：Oyster is Ostreidae animal oyster long (OstreaglgasThun-berg), Crassostrea rivularis
(OstrearivularisGould) or ostrea talienwhanensis Crosse (OstrcatalienwhanensisCrosse) shell, China edge
An extra large band is distributed, and whole year can harvest, and raw to use or forge use, the used time smashes.This taste is salty, puckery, be slightly cold, and returns liver and kidney channel, has
The effect of calming the liver, softening and resolving hard mass, astringent or styptic treatment for spontaneous sweating convergence, there are the function to oyster and the detailed record for curing mainly in successive dynasties medical book.
Oyster first recorded in《Sheng Nong's herbal classic》, top grade is classified as in book.Wherein " oyster, taste is salty flat, and main typhoid fever fever and chills, a kind of malaria is spilt for note
Spill, frightened gas of being enraged, except slow mouse fistula is arrested, woman's under band is red white, and long term usage, strong joint kills perverse trend, macrobiosis." to Han dynasty, Zhang Zhongjing institute
Write《The Treatise on Fevrile Diseases》With《Synopsis Golden Chamber》Just widely treat disease using oyster composition prescription.It is related to compatibility in two books
The prescription of oyster is just up to as many as 11.Above works all embodies important ground of the oyster on tcm clinical practice in varying degrees
Position.Recent studies shows：Oyster containing the nutrition such as 18 kinds of amino acid, liver glycogen, B family vitamin, taurine and calcium, phosphorus, iron, zinc into
Point, often eating can improve immunity of organisms, and its contained taurine can reducing blood lipid, hypotensive.Oyster is to go through version《Chinese Pharmacopoeia》Receive
The tcm clinical practice common medicine of load.
Bulk drug used in the present invention can meet Quality Standards of Health Foods requirement.
Compared to prior art, the beneficial effects of the present invention are：
Pepo reducing fever and causing diuresis in side, relieving restlessness are quenched the thirst, moisten the lung and relieve the cough, dispersing swelling and dissipating binds, treatment oedema abdominal distension, polydipsia, sore
The disease such as poison and ephritis, cirrhotic ascites.Pepo is aided with other 7 taste compositions such as pumpkin as main component；Pumpkin
It is sweet, warm in nature, enter spleen, stomach, tonifying middle-Jiao and Qi, anti-inflammatory analgetic；Chinese yam nature and flavor are sweet, flat, nontoxic.Return through returns spleen, lung, kidney channel；Tool
Have it is warming spleen and stopping diarrha take the photograph saliva, warm up kidney contracting urine controlling nocturnal emission with astringent drugs the effect of.Fructus alpiniae oxyphyllae is usually used in deficiency-cold in spleen and stomach, vomiting, diarrhea, crymodynia in abdomen, mouth
Many salivas, enuresis with renal asthenia, frequent micturition, seminal emission, gonorrhoea.Oyster controls that urine number is more, little Bian Lin Bi.All medicines share, play altogether invigorating Qi and tonifying kidney,
The effect of dredging collateral contracting spring, improvement women frequent micturition, urinary incontinence.Additionally, the present invention is also processed raw material using " cold-press ", and will squeezing
Cake is processed further treatment and obtains active ingredient using water extraction mode, makes full use of raw material；In extraction process add fructus alpiniae oxyphyllae, when
Return, oyster, fructus alpiniae oxyphyllae have it is warming spleen and stopping diarrha take the photograph saliva, warm up kidney contracting urine controlling nocturnal emission with astringent drugs the effect of.Contain abundant Zn-ef ficiency, oyster in Radix Angelicae Sinensis
The materials such as contained several amino acids, vitamin.The present invention is attempted being combined pumpkin seed oil with water extract first and added simultaneously
The materials such as Radix Angelicae Sinensis, oyster heighten the effect of a treatment, without any side effects, make active ingredient utilization rate higher, make full use of the property of raw material
Can, waste small, effect good.And achieve ideal therapeutic effect.
Specific implementation method
Further describe the present invention with reference to specific comparative example and embodiment, advantages of the present invention and feature will be with
Description and it is apparent.But these embodiments are only exemplary, do not constitute any limitation to the scope of the present invention.Ability
Field technique personnel should be understood that without departing from the spirit and scope of the invention can be to the details of technical solution of the present invention
Modified with form or replaced, but these modifications and replacement are each fallen within protection scope of the present invention.
Comparative example 1
(1) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material A, and the pumpkin seedcake after squeezing, it is standby
With；
(2) water extraction
Pumpkin seedcake after squeezing is extracted using water extraction method, and Extracting temperature is 100 DEG C, extraction time is 1 hour, material
Liquid weight ratio is 1：10, filtering, concentration is dried, and obtains final product pumpkin water extract B, standby；
(3) mix
5g material As, 5g material B are weighed by formula ratio, is well mixed, granulation is obtained final product.
Comparative example 2
(1) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material A, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material B, and squeeze after pepo
Cake, it is standby；
(2) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing is respectively adopted water extraction method and is extracted, and Extracting temperature is 100
DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10, filtering, concentration is dried, and respectively obtains pumpkin, pepo
Water extract, i.e. material C, D, it is standby；
(3) mix
2.5g material As, 2.5g material B, 2.5g material C, 2.5g materials D are weighed by formula ratio to be well mixed, granulation, i.e.,
.
Comparative example 3
(1) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material A, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material B, and squeeze after pepo
Cake, it is standby；
(2) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted, and extract temperature
Spend for 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：20, filtering, concentration is dried, and respectively obtains pumpkin, western calabash
The water extract of reed seed, fructus alpiniae oxyphyllae, respectively material C-E, it is standby；
(3) mix
2.5g material As, 2.5g material B, 2.5g material C, 2.5g material D, 1.5g material E are weighed by formula ratio, mixing is equal
Even, granulation is obtained final product.
Comparative example 4
(1) sterilize
Chinese yam is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted, and extract temperature
Spend for 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1:10, filtering, concentration is dried, and respectively obtains pumpkin, western calabash
The water extract of reed seed, fructus alpiniae oxyphyllae, respectively material D-F, it is standby；
(4) mix
15g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 1.5g materials are weighed by formula ratio
F, is well mixed, and granulation is obtained final product.
Comparative example 5
(1) sterilize
Chinese yam is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted,
Extracting temperature is 100 DEG C, extraction time is 1 hour, feed liquid weight ratio is 1:10, filtering, concentration is dried, and respectively obtains pumpkin
Seed, pepo, Radix Angelicae Sinensis, the water extract of fructus alpiniae oxyphyllae, respectively material D-G, it is standby；
(4) mix
15g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 1.5g materials are weighed by formula ratio
F, 1.5g material G, are well mixed, and granulation is obtained final product.
Embodiment 1
(1) sterilize
Chinese yam is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material A, it is standby；
Oyster is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material B, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material C, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material D, and squeeze after pepo
Cake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted,
Extracting temperature is 100 DEG C, extraction time is 1 hour, feed liquid weight ratio is 1:10, filtering, concentration is dried, and respectively obtains pumpkin
Seed, pepo, Radix Angelicae Sinensis, the water extract of fructus alpiniae oxyphyllae, respectively material E-H, it is standby；
(4) mix
20g material As, 2g material B, 1.25g material C, 1.25g material D, 1.25g material E, 1.25g things are weighed by formula ratio
Material F, 1g material G, 1g material H, is well mixed, and granulation is obtained final product.
Embodiment 2
(1) sterilize
Chinese yam is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material A, it is standby；
Oyster is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material B, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material C, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material D, and squeeze after pepo
Cake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted,
Extracting temperature is 100 DEG C, extraction time is 1 hour, feed liquid weight ratio is 1:10, filtering, concentration is dried, and respectively obtains pumpkin
Seed, pepo, Radix Angelicae Sinensis, the water extract of fructus alpiniae oxyphyllae, respectively material E-H, it is standby；
(4) mix
15g material As, 0.5g material B, 3.1g material C, 3.1g material D, 3.1g material E, 3.1g materials are weighed by formula ratio
F, 0.5g material G, 0.6g material H, are well mixed, and granulation is obtained final product.
Embodiment 3
(1) sterilize
Chinese yam is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material A, it is standby；
Oyster is carried out into steam sterilizing, be dry, pulverize, cross 100 mesh sieves, obtain material B, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material C, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material D, and squeeze after pepo
Cake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted,
Extracting temperature is 100 DEG C, extraction time is 1 hour, feed liquid weight ratio is 1:10, filtering, concentration is dried, and respectively obtains pumpkin
Seed, pepo, Radix Angelicae Sinensis, the water extract of fructus alpiniae oxyphyllae, respectively material E-H, it is standby；
(4) mix
By formula ratio weigh 15g material As, 1g material B, 2.5g material C, 2.5g material D, 2.5g material E, 2.5g materials F,
1.5g material G, 1.5g material H, are well mixed, and granulation is obtained final product.
The pharmaceutical composition of the invention of experimental example 1 is to improving women frequent micturition, the examination of the pharmacodynamics of the pharmacodynamics test of the urinary incontinence
Test
1. experiment material
Test sample：Composition according to obtained by comparative example 1-5 and embodiment 1-3.Comparison medicine：Atropine.Animal germline：
Healthy female rabbit.The weight of animals：1.3~1.5kg.
2. experimental technique
By rabbit fasting 24h before experiment, drinking-water is not limited.Make its stunning during experiment, quickly remove bladder and urethra；Bladder edge
Facies ventralis center is cut off, and pro ureth spiral gimmick is cut off, and is placed in rinsed clean in Krebs liquid, and urethra is standby.Bladder is fixed on
Fill in the culture dish of Krebs liquid, gently dial except mucous layer, fixed knife blade is along vertical in body of urinary bladder dorsal part center both sides
Row muscle fibre trend cuts two longitudinal muscle bars.Bladder muscle bar is suspended in the perfusion flesh groove full of Krebs liquid, solution keeps
At 37 DEG C, and the mixed gas that volume fraction is 95% oxygen and 5% carbon dioxide are continually fed into, through muscle tone transducer
Two road physiographs are input a signal into, the isometric contraction activity of flesh bar is recorded, once fresh Krebs is changed within every 20 minutes
Liquid, is separately added into the composition and atropic of comparative example 1-5 and embodiment 1-3 during the spontaneous activity stabilization of flesh bar after about 30 minutes
Product, composition dosage 3g/kg, atropine dosage is 0.1mg/kg.8 rabbit of every group for the treatment of, experimental result referring to
Table 1.
The composition and reference substance of the comparative example 1-5 of table 1 and embodiment 1-3 shrink to rabbit in vitro bladder smooth muscle flesh bar lives
Dynamic influence
Note：* represent dosing after with compare P ﹤ 0.01 before dosing.
3. conclusion
From table 1 it follows that comparative example 1-5 groups, the composition of embodiment 1-3 groups can substantially reduce smooth muscle of bladder
Frequency and amplitude that flesh bar shrinks, and its effect is presented more and more obvious trend with comparative example 1-5 groups to embodiment 1-3 groups,
The effect that 3 groups of embodiment is the most notable.Illustrate that drug effect that pumpkin is combined with pepo is higher than the drug effect of one-component, and
Fructus alpiniae oxyphyllae, Chinese yam and angelica, oyster play a driving role to the drug effect of the present composition.
The pharmaceutical composition of the invention of experimental example 2 to women frequent micturition, urgent urination, the urinary incontinence clinical research
Urine urgency-frequency is a kind of common disease, and with the increase at age, its incidence of disease gradually increases, and pathogenesis compared with
It is complexity, effective treatment method is lacked at present.Urine urgency-frequency controlled micturition number of times is up to 20~30 times/d, and total volume of urine is without increasing
Plus.Patient has urgency but painless, drastically influence the daily life of patient.
1. clinical data and method
1.1 clinical datas and packet
In in March, 2016 to choosing 60 between in September, 2016 with frequent micturition, urgent urination as illness and the course of disease is more than the female of 1 month
Property patient, is randomly divided into 2 groups, 3 groups of every group of 30 people, respectively control group, embodiment.
1.2 inclusive criterias
Sex is women, and the age, night total urination time was average more than 3 times between 35-55 Sui.
1.3 diagnostic criteria
Tcm symptom is aversion to cold and cold limbs, frequent urination, the powerless deficiency of vital energy, soreness of waist and knee, pale tongue with white fur, excludes bladder and urethra
The urine urgency-frequency patient that organic disease patient and tumour, renal failure etc. cause.
1.4 treatment methods
Control group uses regular western medicine treatment, oral Racanisodamine piece (5mg/ pieces, one time 2,3 times a day)；It is real
Apply the composition (25g/ times, 3 times a day) that 3 groups of example according to dosage takes embodiment 3.
1.5 observation index
Usually worked and rested by patient, solution urine to the greatest extent is gone to bed the following period of time fallen asleep and got up only to morning next day, record urine
Number of times, continuously urine amount, record 7 days.Average.Respectively at before medication, medication 3 months and the course for the treatment of terminate after each observation 1 time.
1.6 effective evaluations
It is to cure that symptom is wholly absent, symptom substantially mitigates as effective, symptom mitigation but not up to 50% be effective, disease
Shape does not mitigate even plus severe one is invalid.
2. result
The control group enuresis nocturna frequency index situation of change of table 2
| Before treatment | Treatment 3 months | Treatment 6 months | |
| Urine | 4.6±1.2 | 2.1±0.8* | |
| Nocturnal urine volume (ml) | 648.1±113.5 | 390±105.4* |
Note：△P ＜ 0.05 compared with pre-treatment, * the P ＜ 0.05 compared with treatment 3 months.
3 embodiment of table, 3 groups of enuresis nocturna frequency index situations of change
| Before treatment | Treatment 3 months | Treatment 6 months | |
| Urine | 4.8±1.4 | 2.0±0.8* | |
| Nocturnal urine volume (ml) | 650.3±124.1 | 378.3±135.1* |
Note：△P ＜ 0.05 compared with pre-treatment, * the P ＜ 0.05 compared with treatment 3 months.
3 groups of 4 embodiment of table and control group Comparison of therapeutic
| Number of cases | It is effective | Effectively | It is total effective | |
| Control group | 30 | 10 (33.3%) | 11 (36.6%) | 21 (69.9%) |
| 6 groups of embodiment | 30 | 12 (40%) * | 13 (43.3%) * | 25 (83.3%) * |
Note：* P ＜ 0.05 compared with control group.
Result shows that control group makes moderate progress with administration group enuresis nocturna frequency after medication, average enuresis nocturna number of times and nocturnal urine output
Significantly reduce, illustrate that health-care food composition of the invention has some improvement to women frequent micturition, urgent urination.
Claims (8)
1. it is a kind of to improve women frequent micturition, the health-care food composition of the urinary incontinence, it is characterised in that by the raw material group of following weight portion
Part composition：0.4~5 part of pumpkin seed oil, 0.4~4 part of pumpkin water extract, 15~30 parts of Chinese yam, water extract of Alpinia oxyphylla Miq 0.6
~3 parts, 0.4~5 part of pepo oil, 0.4~5 part of pepo water extract, 0.5~3 part of Radix Angelicae Sinensis water extract, oyster
0.5~2 part.
2. health-care food composition according to claim 1, it is characterised in that by the material component group of following weight portion
Into：2.5 parts of pumpkin, 2.5 parts of pumpkin water extract, 15 parts of Chinese yam, 1.5 parts of water extract of Alpinia oxyphylla Miq, pepo oil 2.5
Part, 2.5 parts of pepo water extract, 1.5 parts of Radix Angelicae Sinensis water extract, 1 part of oyster.
3. the preparation method of health-care food composition described in claim 1 or 2, it is characterised in that comprise the following steps：
(1) sterilize
Chinese yam is carried out into sterilization treatment, be dry, pulverize, sieved, obtain material A, it is standby；
Oyster is carried out into sterilization treatment, be dry, pulverize, sieved, obtain material B, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is extracted oil, and obtains the pumpkin seedcake after pumpkin seed oil, i.e. material C, and squeezing,
It is standby；
Pepo is peeled off, and takes seed benevolence, by the oil expression of pepo benevolence, obtains pepo oil, i.e. west after material D, and squeezing
Cucurbit seedcake, it is standby；
(3) water extraction
The cucurbita pepo seedcake after pumpkin seedcake, squeezing after squeezing, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae are respectively adopted water extraction method and are extracted, and filter,
Concentration, dries, and respectively obtains the water extract of pumpkin, pepo, Radix Angelicae Sinensis, fructus alpiniae oxyphyllae, respectively material E-H, standby；
(4) mix
Eight kinds of materials of A-H are weighed according to the weight portion described in claim 1 or 2, is well mixed, granulation is obtained final product.
4. preparation method according to claim 3, it is characterised in that sterilization treatment described in step (1) is steam sterilizing
Treatment；The sieving was 80~100 mesh sieves.
5. preparation method according to claim 3, it is characterised in that by pumpkin seed oil expression to make described in step (2)
Cold press, 70 DEG C of adjustment oil extruder bore temperature, pressure 3.5Mpa, rotating speed 36r/min, repeatedly 3~4 times are carried out with oil press.
6. preparation method according to claim 3, it is characterised in that be by the oil expression of pepo benevolence described in step (2)
Cold press, 80 DEG C of adjustment oil extruder bore temperature, pressure 3.6Mpa, rotating speed 36r/min, repeatedly 3~4 times are carried out using oil press.
7. preparation method according to claim 3, it is characterised in that the Extracting temperature that water described in step (3) is extracted is
100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10~1：20.
8. the health-care food composition described in claim 1 or 2 is preparing answering in improving women frequent micturition, urinary incontinence health food
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710062636.2A CN106860814B (en) | 2017-01-22 | 2017-01-22 | Health food composition for improving female frequent micturition and urinary incontinence and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710062636.2A CN106860814B (en) | 2017-01-22 | 2017-01-22 | Health food composition for improving female frequent micturition and urinary incontinence and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106860814A true CN106860814A (en) | 2017-06-20 |
| CN106860814B CN106860814B (en) | 2020-02-18 |
Family
ID=59165724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710062636.2A Active CN106860814B (en) | 2017-01-22 | 2017-01-22 | Health food composition for improving female frequent micturition and urinary incontinence and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106860814B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403851A (en) * | 2018-04-25 | 2018-08-17 | 惠州嘉联生物科技开发有限公司 | A kind of composite enzyme and preparation method thereof for alleviating women frequency symptoms |
| CN110664989A (en) * | 2018-07-18 | 2020-01-10 | 广州市尚昇生物科技有限公司 | Striae gravidarum removing composition containing polypeptide and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217772A (en) * | 2011-04-21 | 2011-10-19 | 东北林业大学 | Nutrition reinforcement type pumpkin seed juice and preparation process thereof |
| CN103930121A (en) * | 2011-10-11 | 2014-07-16 | Cj第一制糖株式会社 | Composition for preventing and treating overactive bladder syndrome |
| CN106039183A (en) * | 2016-08-12 | 2016-10-26 | 姜晓华 | Traditional Chinese medicinal composition used for treating frequent urination and uroclepsia |
-
2017
- 2017-01-22 CN CN201710062636.2A patent/CN106860814B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217772A (en) * | 2011-04-21 | 2011-10-19 | 东北林业大学 | Nutrition reinforcement type pumpkin seed juice and preparation process thereof |
| CN103930121A (en) * | 2011-10-11 | 2014-07-16 | Cj第一制糖株式会社 | Composition for preventing and treating overactive bladder syndrome |
| CN106039183A (en) * | 2016-08-12 | 2016-10-26 | 姜晓华 | Traditional Chinese medicinal composition used for treating frequent urination and uroclepsia |
Non-Patent Citations (1)
| Title |
|---|
| 陈聪颖等: "西葫芦的化学和药理研究", 《国外医药.植物药分册》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403851A (en) * | 2018-04-25 | 2018-08-17 | 惠州嘉联生物科技开发有限公司 | A kind of composite enzyme and preparation method thereof for alleviating women frequency symptoms |
| CN110664989A (en) * | 2018-07-18 | 2020-01-10 | 广州市尚昇生物科技有限公司 | Striae gravidarum removing composition containing polypeptide and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106860814B (en) | 2020-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103141709B (en) | Carp feed and preparation method thereof | |
| CN103652361B (en) | Feed for postpartum sow in lactation period of 1-20 days and preparation method thereof | |
| CN102940155B (en) | Duckling feed for cherry valley duck and preparation method thereof | |
| CN103734428B (en) | A kind of glossy privet fruit health-care tea improving immunity and preparation method thereof | |
| CN103749982B (en) | Feed for improving egg yield, traditional Chinese medicine additive and preparation method thereof | |
| KR101787432B1 (en) | Method for manufacturing oriental medicine composition which improves menorrhagia and dysmenorrhea comprising fermented velvet antler and yeast hydrolysate | |
| CN103355555A (en) | Feed for laying hen in egg-laying peak stage and preparation method thereof | |
| CN104873763A (en) | Health-care product for conditioning Qi deficiency constitution | |
| CN101284122A (en) | Soft capsules for resisting the climate sickness | |
| CN105614667A (en) | Heart-nourishing selenium-rich rice noodle and preparation method thereof | |
| CN104206905A (en) | Feed additive for reducing cholesterol content in eggs | |
| CN102755596A (en) | Traditional Chinese medicine for treating phlegm-dampness hyperplasia of mammary glands and preparation method thereof | |
| CN105999212A (en) | Composition having alcohol effect dispelling effect and preparation method and application thereof | |
| CN103238757B (en) | Compound feed containing fermented cottonseed meal for chicken for eggs and preparation method thereof | |
| CN105029421A (en) | Health care product for conditioning phlegm-dampness constitution | |
| CN104161194A (en) | Feed used for reducing content of cholesterol in egg | |
| CN106860814A (en) | A kind of improvement women frequent micturition, health-care food composition of the urinary incontinence and its preparation method and application | |
| CN104970220A (en) | Compound feed for sows in suckling period and preparation method thereof | |
| CN101904414A (en) | Chicken feed and method for processing eggs with Chinese medicinal tincture | |
| CN104771462A (en) | Traditional Chinese medicine for treating chronic bronchitis and preparation method thereof | |
| CN103750096A (en) | Propolis honey cream rich in plant essence and preparation method thereof | |
| CN106036906A (en) | Selenium-enriched kudzu root guilinggao for nourishing blood and calming nerves and preparation method thereof | |
| CN1323598A (en) | Antifatigue capsule | |
| CN105617268A (en) | Medicine for treating scale keratinization type beriberi | |
| CN103815348A (en) | Dahurian rose fruit yin-nourishing and dryness-moistening hot-pot condiment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171013 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant after: Harbin quick good Pharmaceutical Co., Ltd. Address before: 150025 middle section of Beijing Road, Limin economic and Technological Development Zone, Harbin City, Heilongjiang Applicant before: Loctite Harbin Pharmaceutical Co., Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |