CN101284122A - Soft capsules for resisting the climate sickness - Google Patents
Soft capsules for resisting the climate sickness Download PDFInfo
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Abstract
The invention relates to a soft capsule for resisting climate sickness, and belongs to the technology field of nutritious and health food. The technical proposal is that the soft capsule for resisting climate sickness contains vegetable oil 95-5 wt%, fructo-oligosaccharide 4.5-85 wt%, and suspending agent 0.5-10 wt%. The invention aims to provide a nutritious and health food, which is effective in preventing and improving climate sickness symptom of tourist, with convenient administering, easy carrying, good safety, and non-toxicity.
Description
Technical field
The present invention relates to a kind of anti-being not acclimatized soft capsule, belong to nutrition, health food technology field.
Background technology
People have been owing to having changed uncomfortable that geographical environment takes place, and as inappetence, spirit is tired, sleep is bad, even gastrointestinal upset, nausea and vomiting, constipation stomachache, diarrhoea are become thin etc. to be commonly called as and be " being not acclimatized ".This situation very on the road more sees.As from the Plain to the plateau, because rarefaction of air, air pressure descends and the discomfort of appearance; From south to the north, the discomfort that produces owing to the change of temperature, humidity; From the rural area to the city, incompatible and tired, insomnia or the like occurs to noise, light, all belong to the symptom of being not acclimatized.Under normal circumstances, people's skin, mucosa and the tract that communicates with the external world all have microorganisms such as antibacterial, fungus to exist, and these floras interdepend, mutual restriction, are keeping human body and extraneous balance.When people went out, because living environment makes flora that variation take place, pathogenic bacterium can not get restriction suddenly, and those antibacterials that normally provide the nutrient substance facilitating digestion to absorb at ordinary times, can be suppressed again and reduced, thereby " being not acclimatized " symptom occur.
In the middle of " being not acclimatized ", especially more common with " vomiting and dirarrhea ", because the easiest disequilibrium of gastrointestinal flora causes gastrointestinal disturbance, the water of various places, soil, grain, air, temperature, humidity are all different, the gastrointestinal function that weariness from a tiring journey and gastrointestinal incompatibility causes descends, add the incompatibility on the diet, so just to a new local being not acclimatized that takes place easily.But, have some the locality earlier and be easy to digestion, nutritious food, little to the gastrointestinal stimulation on the one hand, can make the intestines and stomach slowly adapt to local diet on the other hand.Some human diet go up to note, being not acclimatized symptoms such as gastrointestinal upset, nausea and vomiting, stool be undesired still might occur, therefore before travel, had better with on improve the medicine and the health food of being not acclimatized symptom.
From the angle of modern medicine, so-called " being not acclimatized ", essence is because the water and soil of different regions and the change of dietary structure, causes the disorderly and digestive tract function imbalance that causes of intestinal microbial population.Content of mineral substances in the water in different places is also different.The number of chemical element that contains in the water is talked about, and as ferrum, fluorine, iodine, copper, zinc, calcium, magnesium etc., wherein calcium salt is directly relevant with hardness of water with magnesium salt, and their content in water is high more, and hardness of water is just big more, otherwise then opposite.Originally custom is drunk soft people, uses hard water suddenly instead, can impel the enterokinesia aggravation, and times of defecation increases, and causes diarrhoea.On the contrary, originally the custom people that drinks hard water drinks soft water suddenly, can impel enterokinesia to slow down, and times of defecation reduces or constipation.If living environment generation great change, dietary structure also can change usually, and nature will destroy the intestinal microbial population original ecological balance.
Medical research shows that the crowd who lives in high protein fleshiness food HFD area compares, and bacterial species and quantity have significant difference in two kinds of crowds' the feces.Therefore enter different regions, change original geographic dietary structure person, will inevitably change long classification and quantity to normal flora, thereby the long ecological balance of influence to flora, cause the gastrointestinal function disorder, even diarrhoea is more than, " being not acclimatized " phenomenon that occurs it has often been said.For the prevention being not acclimatized is suffered from diarrhoea, if go on business or out on tours in your way far away, preferably prepare some regulating gastointestinal function health foods and medicine at one's side, in case during because of environment change generation being not acclimatized, should in time take, and note adjusting an individual human diet.If got back to this locality, when intestinal microbial population returned to original poised state, gastrointestinal upset and symptom of diarrhea also will disappear thereupon.In addition,, should note the hygienic habit that keeps good, have a rest on time, form good rule of life, so not only can help to overcome soil and refuse to obey, also help the healthy of each traveller simultaneously in the life of new place.
Constipation is a common on the road problem of child and old people, the expert represents, infant and the old people adaptive faculty of environment to external world are lower, and the out on tours meeting makes the daily life system havoc, add the long-distance car inconvenience of going to toilet, or do not want to go up factor such as public lavatory, allow the intestines and stomach can't normal creepage of gastrointestinal functions, the vegetables and fruits intake reduces when going on a tour again, makes feces repeatedly be absorbed moisture in intestinal, more and more dried, and cause the phenomenon of difficult defecation or constipation." golden period " of going on a tour just holiday.Just in the HappyTime that everybody makes a sightseeing tour, some diseases also can invite oneself.Some people can occur having no appetite because of the change of geographical environment, so-called being not acclimatized symptoms take place for dizzy unable, lethargy, diarrhoea etc.; The somebody can suffer from diseases such as flu or digestive system because of wind and cold invasion or improper diet.The little medicine-chest that is ready to the journey health care is the good assistant who prevents and improve journey being not acclimatized symptom.
Sleep is most important for normal biological function.If not sleep, people's immune system just can fine execution functions, for the tourism crowd who changes living environment, the sleep quality extremely common problem especially that descends.Sleep is to act on nervous process keeping the poised state of brain, fully will be dead as mice by sleep deprivation 17～20 days, and their hair can begin to come off, and the excessing metabolism that becomes is even plant oneself a large amount of heat energy that also can burn.This means that sleep is exactly energy-conservation and energy storage, do not have enough sleep and just will keep the physiological equilibrium that sleep can allow the people keep the vigor of longer time equally by the intravital energy of burning.The mankind have a variety of causes can cause death, but those adults that obtain sleep in 7～8 hours every night are that mortality rate is minimum.Sleep study has also shown the situation of an important insulin resistant, insulin resistant be the affecting glucose metabolism and cause fat a kind of before diabetic symptom.When the strict restriction of people was only slept 4 hours every night, in two weeks, will allow a people of 18 years old aspect the ability of glucose metabolism as an old man of 60 years old.This sleep deprivation metabolism syndrome also may increase the demand of saccharide and a large amount of foods.Sleep is to immune influence, research worker Eve Wan Kaote of Chicago University's research sleep uses influenza vaccines to the student's (only sleeping every night 4 hours in continuous six days) who does not have enough sleep, for the challenge of influenza virus, these students' immune system has only produced half that under normal circumstances can produce antibody.Simultaneously, these students' cortisone (a kind of hormone relevant with anxiety) level rises, and sympathetic nervous system is excited, causes heart rate and blood pressure to increase.
Flourish along with Tibet, Qinghai-Tibet, Yunnan Lijing tourist industry, large quantities of visitors enter the highlands and go sightseeing, but the phenomenon of plateau being not acclimatized is a very important problem, it may bring uncomfortable to the traveller, and can not allow the traveller loosen mood, pressure in alleviation work and the life, so the beautiful scenery of the Nature that indulges in luxuriousness to one's heart's desire is prevention and to improve the being not acclimatized symptom be a very important and anxious problem to be solved for highland tour crowd.
Summary of the invention
For addressing the above problem, the object of the invention is to provide a kind of effective prevention and improves the being not acclimatized symptom, and taking convenience is easy to carry about with one, the safety non-toxic nutritional health food.
For achieving the above object, the invention provides a kind of soft capsule of anti-being not acclimatized, the content of soft capsule is made of by a certain percentage vegetable oil, oligofructose and suspending agent, wherein the percentage by weight of vegetable oil is 95%-5%, the percentage by weight of oligofructose is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
The vegetable oil of preparation in the soft capsule is by in Princepia utilis oil, Camellia oil, olive oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil one or several.
Content by the anti-being not acclimatized soft capsule of above-mentioned preparation is by Princepia utilis oil percentage by weight 95%-5%, and the percentage by weight of oligofructose is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
Improve the effect of being not acclimatized symptom for strengthening soft capsule, can add following adjustment gastrointestinal bacterial flora, loosening bowel to relieve constipation, improve sleep state, the antifatigue material, collaborative performance effect can add Rhizoma Zingiberis Recens, Pericarpium Citri Reticulatae, Bulbus Allii, Herba Pogostemonis, Folium Perillae, Fructus Crataegi, Semen Raphani, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Fructus Hippophae, spirulina, Semen Ziziphi Spinosae, Margarita powder, Fructus Amomi, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Lycii, Fructus Mori, Arillus Longan, Radix Puerariae, Poria, Flos Caryophylli, Semen Cassiae, Fructus Cannabis, Herba Houttuyniae, Radix Glycyrrhizae, Semen Arecae, Rhizoma Coptidis, the Radix Astragali, Flos Carthami, green tea, Radix Panacis Quinquefolii, Ganoderma, Folium Ginkgo, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Semen Sesami, Herba Cistanches, Radix Et Rhizoma Rhei, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Colla Corii Asini, dietary fiber, oligosaccharide, probiotic bacteria, lactobacillus, isomerized lactose, calcium lactate, polydextrose, chitosan, melatonin, in the vitamin E one or several.
Oligofructose claims fructooligosaccharide again, is called as the functional factor of third generation health food.Can make the useful Bacillus bifidus breeding of enteral increase 5-10 doubly, suppress the growth of harmful bacterium such as bacteroid, clostridium, bacillus perfringens, reduce quantity and be about 50%-70%, remove constipation, improve chronic diarrhea, dysentery; Can drain harmful substance, prevent colorectal cancer etc.; The energy enhancing immunity prevents the dysbacteriosis that various medicines (as antibiotic) cause, because oligofructose can only be absorbed by intestinal bacteria, seldom can be decomposed by the enzyme in the digestive tract, and extremely difficulty is absorbed by the body.Therefore can not cause obesity after taking in.So its calorific value is low, can not cause fat.
Princepia utilis has another name called Folium Prinsepiae Utilis, the fruit of buying oil, and is this plant of Rosaceae Folium Prinsepiae Utilis, mainly is grown in mountain region, the barren hill of 1800～3200 meters in cloud, expensive, valley district height above sea level, belongs to the woody oleiferous plants crop of a kind of " happiness is cool " of high and cold mountain area.The Princepia utilis whole body all is precious, and its tree, root, leaf, flower, fruit all have very high value, and the edible refrigerant invigorating the stomach and promoting digestion of the tender point of Princepia utilis has better action to suppressing oral cavity and enteritis; With Princepia utilis flower, tender point, leaf and fibrous root decoction toothache and throat inflammation there is obvious anti-inflammatory analgetic effect.Princepia utilis oil is rich in fatty acid and fat-soluble A, D, E, K and the various trace elements of multiple needed by human, is described as " eatable cosmetics " and " human body replenishes the new source of essential fatty acid " by nutritionist.
Olive oil is the pure natural fruit oil juice that the Fructus oleae europaeae fruit obtains by the physics cold pressing process after artificial the harvesting in a short period of time.Be rich in various antioxidant vitamin Es in the olive oil, carotenoid and phenolic compound, abundant trace element Squalene, Flavonoid substances, can strengthen the immunity of human body, slow down aging, these materials are being eliminated free radical and some and chronic disease and the relevant molecule of aging, and aspect such as life-saving all plays a part positive.
Rhizoma Zingiberis Recens is the dry root and rhizome of zingiber, adopts supercritical CO
2Brown liquid oil or powder that extraction is processed into, gas perfume (or spice), acrid in the mouth is peppery, the pungent gastrotonica of armaticity, warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, functions such as warming middle-JIAO hemostasis, diaphoresis preventing or arresting vomiting, detoxifcation.Main active is a zingiberene, gingerol, zingiberol, zingiberone, cineole etc.The clinical coldness and pain in the epigastrium that can be used for, Deficiency and coldness of spleen and stomach, stomachache are told and are let out, the cold extremities faint pulse, phlegm retention is breathed with cough.Blood pressure lowering, blood fat reducing, vessel softening, the prevention myocardial infarction; Alleviate and the elimination stomachache; Dizzy and the vomiting that treatment Common Cold, acute gastroenteritis, peptic ulcer motion bring.
Bulbus Allii is a liliaceous plant, and Bulbus Allii is warm in nature, acrid in the mouth, and the energy circulation of qi promoting disappears stagnant, and dirty getting rid of evils warded off in the warming the stomach spleen invigorating, the detoxifcation parasite killing.Active ingredient is the diallyl trisulfide, is applied to bacillary dysentery, viral enteritis, peptic ulcer, atrophic gastritis, atherosclerosis, and the protection heart is avoided invasion and attack.Bulbus Allii is called as natural antibiotics, micrococcus scarlatinae, staphylococcus aureus, meningococcus, streptococcus pneumoniae, tubercule bacillus, dysentery bacterium, Bacillus typhi, escherichia coli, vibrio cholera etc. are all killed or inhibitory action, and do not produced drug resistance.
Pericarpium Citri Reticulatae is the peel of multiple Fructus Citri tangerinae classes such as rutaceae tangerine produced in fujian province or Zhu's Fructus Citri tangerinae, is used as medicine with peel (Pericarpium Citri Reticulatae).Pericarpium Citri Reticulatae contains volatile oil, main component d-limonen, citral, nobiletin and Hesperidin.Acrid in the mouth, hardship, temperature is gone into spleen, lung meridian, regulates the flow of vital energy to be good for the stomach, drying dampness to eliminate phlegm, to separate greasy lasting, stopping nausea and vomiting by lowering the adverse flow of QI effect.Pericarpium Citri Reticulatae has the delicate fragrance of Fructus Citri tangerinae, and its bitter substance is representative " limonoid " with limonene and bitter principle, and this limonoid is soluble in water, helps food digestion.Its contained volatile oil has gentle stimulation to gastrointestinal tract, but pneumatosis in the intestinal tube is got rid of in the secretion of facilitating digestion liquid, and stimulating appetite is fit to inappetence, distension and fullness in the abdomen, and abundant expectoration cough person is edible.
Folium Perillae is a Labiatae annual herb plant, has another name called red, the red SUMA of SUMA, in China various places distribution is arranged all.Have the cold expelling of inducing sweat, circulation of qi promoting and in, relieving cough and asthma, the wide intestinal of sharp diaphragm, the effect of separating all poison.Be used for cold more, fever with chills, headache nasal obstruction is doublely seen cough or the person of not relaxing uncomfortable in chest.Folium Perillae can be dispersed exterior cold, opens lung qi dispersing gas, can with the same usefulness of Rhizoma Zingiberis Recens, be used for stagnation of QI in spleen and stomach, uncomfortable in chest, the card of vomiting; The Folium Perillae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, the stomach function regulating preventing or arresting vomiting, cold partially person and Herba Pogostemonis are with using; Partial heat person can use together with Rhizoma Coptidis.Inclined to one side stagnation of QI expectorant knot person, normal and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis are used together.Be used for vomiting during pregnancy again, the breast abdominal distention is vexed, and normal and Pericarpium Citri Reticulatae, Fructus Amomi compatibility are to strengthen its preventing or arresting vomiting, antiabortive effect.Feed fish Eriocheir sinensis and the stomachache that causes is vomited and diarrhoea, the Folium Perillae list with or join the Rhizoma Zingiberis Recens decoction.
Herba Pogostemonis is the aerial parts of labiate Herba Pogostemonis, and herb has strong fragrance, be widely distributed in all over China, and be one of tropical important industrial crops.Herba Pogostemonis contains volatile oil 0.28%, and main component is an estragole, accounts for more than 80%, and contains anethole, anisaldehyde, limonene etc.Be used as medicine with stem and leaf on the Chinese medicine, slightly warm in nature, acrid-sweet flavor has that arresting vomiting by invigorating the stomach, removing dampness are amusing, the diaphoresis equivalence, cure mainly experience heat-damp in summer, have a headache and fever, disease such as abdominal distention uncomfortable in chest, vomiting dysentery.Herba Agastaches Rugosae volatile oil can promote gastric secretion, strengthens eupepsy, and gastrointestinal tract is had spasmolysis.The clinical gastritis, chest and abdomen swelling and pain, vomiting of being used for the treatment of is had loose bowels, is had a headache and fever and anicteric hepatitis.
Semen Ziziphi Spinosae is the seed of Rhamnaceae arbor Ziziphi Spinosae mature fruit, dries to form, and mainly contains jujuboside, betulic acid, betulin etc.Have good improvement sleep, resisting oxygen lack has slow down aging, arrhythmia simultaneously, the blood lipid regulation effect, and the traditional Chinese medical science is thought tonifying liver, mind calming, arresting sweating, the effect of promoting the production of body fluid, and can be used for restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body etc.
Melatonin claims melatonin again, and melatonin is mammal a kind of hormone that (comprising the people), the brain pinus was produced, and the adjusting that sleep is inclined to plays an important role, and is called the physiologically substance of biochron phasic property.This product can promote physiological sleep impulsion effectively, improves sleep quality and brain electrical acti.To time difference of long-range flight, put upside down round the clock, the long-term mistake slept, climacteric emotional lability, sleep disorder has good effect.Melatonin can enter cell lipid film and nucleus, is present best antifree radical agent, and life-time service can make in the body the purple brown speckle of body surface and some pigment subtract to take off.
Dietary fiber claims cellulose, dietary fiber etc. again, belongs to the polysaccharose substance that can not be absorbed by human consumption.Modern study shows that dietary fiber has considerable effect to health, is called as the 7th class nutrient.Dietary fiber has the colon of promotion function, prevention colon cancer, the anti-effect that treats constipation.The dietary fiber water absorption is strong, and faecal volume is increased, and makes it softening simultaneously.Thereby can prevent and treat habitual constipation and corresponding some diseases, we can say that dietary fiber is an intestinal interior " cleaner " worthy of the name.The fiber meals can make stomach produce feeling of repletion, with control heat production nutrients intake, thereby play controlling body weight, prevent obesity action.
Calcium lactate be white to off-white color crystalline powder or granule, have and replenish the calcium, bone density improving improves the osteoporosis effect, its absorbance is better than other calcium preparation.And calcium lactate can reduce capillary permeability and increase density, and effects such as antiinflammatory, anti-angiogenic mobility's edema and antiallergic are arranged.And can keep the neuromuscular NE, strengthen the cerebral cortex process of inhibition; The effect of antagonism magnesium is arranged during high concentration, also can alleviate smooth muscle spasm etc., be used for anaphylactic disease, tetany, rickets, various angor and magnesium and poison.
The present invention is according to various places climatic environment, humiture, water quality, food, the weariness from a tiring journey and incompatible gastrointestinal function decline that causes of gastrointestinal, influence to human body physiological function, add and adjust gastrointestinal bacterial flora, improve sleep state, antifatigue material, effectively prevent and improve strange land worker and tourism crowd because of environment change, and the inappetence that takes place, spirit is tired, sleep is bad and symptoms such as gastrointestinal upset, nausea and vomiting, constipation stomachache, diarrhoea, has very high using value and vast market prospect for sales.
The specific embodiment
Below in conjunction with specific embodiment anti-being not acclimatized soft capsule provided by the invention is specifically described, but the invention is not restricted to embodiment described below.
Embodiment 1: a kind of soft capsule of anti-being not acclimatized, it is Princepia utilis oil percentage by weight 75% that its content is formed, oligofructose percentage by weight 20%, Cera Flava percentage by weight 5%.
Preparation technology: Cera Flava is heated to fusion, mixes powerful the stirring 15 minutes with pressed powder and the vegetable oil of having pulverized 120 mesh sieves in the prescription, make its mix homogeneously, the degassing is pressed mill by colloid mill, form uniform and stable liquid, mixed liquor is standby after filtering.With gelatin: glycerol: water: antiseptic=1: 0.4: 1.05: offset plate is made in 0.001 ratio dissolving can adhesive tape, mixed liquor is placed between two blocks of offset plates again, regulates out the thickness and the uniformity of rubber, forming with the punching block compacting.Continuous production adopts rotation Zhanang machine automatically, and the adhesive tape that two machines are made automatically moves round about, arrive rotating mould before, the part combination of having pressurizeed, this moment, medicinal liquid entered between adhesive tape through conduit from filling pump, rotated into groove, the whole roll compacting combinations of back adhesive tape, unnecessary adhesive tape cutting is got final product, the soft gelatin capsule of making, cooling earlier is fixing, and the reuse washing with alcohol is deoiled, be drying to obtain every heavily about 0.5g.
Embodiment 2: a kind of soft capsule of anti-being not acclimatized, it is Princepia utilis oil percentage by weight 75% that its content is formed, Radix Ginseng extract percentage by weight 10%, Radix Astragali extract percentage by weight 5%, Rhizoma Coptidis extract percentage by weight 5%, oligofructose percentage by weight 2%, Cera Flava percentage by weight 3%, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.。
Embodiment 3: a kind of soft capsule of anti-being not acclimatized, it is Princepia utilis oil percentage by weight 45% that its content is formed, olive oil percentage by weight 40%, oligofructose percentage by weight 10%, Cera Flava percentage by weight 4%, vitamin E percentage by weight 1% is by the soft capsule that the preparation technology of embodiment 1 makes, every heavily about 0.5g.
Embodiment 4: a kind of soft capsule of anti-being not acclimatized, it is Princepia utilis oil percentage by weight 30% that its content is formed, olive oil percentage by weight 30%, oligofructose percentage by weight 20%, Semen Ziziphi Spinosae extract percentage by weight 15%, Cera Flava percentage by weight 4%, vitamin E percentage by weight 1%, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Embodiment 5: a kind of soft capsule of anti-being not acclimatized, it is by Princepia utilis oil percentage by weight 60% that its content is formed, oligofructose percentage by weight 10%, Pericarpium Citri Reticulatae extract percentage by weight 10%, Rhizoma Zingiberis Recens extract percentage by weight 5%, Folium perillae extract percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, Cera Flava percentage by weight 5% is formed, and makes soft capsule of the present invention, every heavily about 0.5g by the preparation technology of embodiment 1.
Embodiment 6: a kind of soft capsule of anti-being not acclimatized, it is soybean oil percentage by weight 40% that its content is formed, Princepia utilis oil percentage by weight 20%, oligofructose percentage by weight 15%, spirulina percentage by weight 15%, Radix Puerariae percentage by weight 5%, Cera Flava percentage by weight 5%, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Embodiment 7: a kind of soft capsule of anti-being not acclimatized, it is by Princepia utilis oil percentage by weight 30% that its content is formed, olive oil percentage by weight 25%, oligofructose percentage by weight 10%, Folium perillae extract percentage by weight 10%, Herba Pogostemonis extract percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, Bulbus Allii extract percentage by weight 5%, soybean phospholipid percentage by weight 5% is formed, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Embodiment 8: a kind of soft capsule of anti-being not acclimatized, it is olive oil percentage by weight 40% that its content is formed, Princepia utilis oil percentage by weight 20%, oligofructose percentage by weight 15%, dietary fiber percentage by weight 15%, melatonin percentage by weight 2%, calcium lactate percentage by weight 2%, vitamin E percentage by weight 1%, Cera Flava percentage by weight 5%, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Regulating gastrointestinal function for investigating anti-being not acclimatized soft capsule, improve sleep state, whether the resisting fatigue aspect is effective, and we have carried out the adjustment gastrointestinal bacterial flora respectively, improve sleep state, resisting fatigue experiment, experimentation is divided into animal experiment stage and human trial stage.
One, anti-being not acclimatized soft capsule improves the intestinal microbial population experiment
1. anti-being not acclimatized soft capsule improves the experiment of mouse intestinal flora
(1) method for cultivation of bacteria
Bacillus bifidus: 37 ℃ in BBL agar, anaerobism was cultivated in 48～72 hours;
Lactobacillus: 37 ℃ in LBs agar, cultivated in 48 hours;
Enterobacteria: 37 ℃ in EMB agar, cultivated in 24～48 hours;
Enterococcus: 37 ℃ of sodium azide-crystal violets-Esculin agar, cultivated in 24～48 hours;
37 ℃ in bacillus perfringens: TS ℃ agar, anaerobism was cultivated in 24 hours;
(2) improve mouse intestinal flora experimental technique
Get 40 of Kunming mouses, body weight 20～22g, male and female half and half are divided into 4 groups at random, 10 every group.The content of anti-being not acclimatized soft capsule is taken out the back dilution, be mixed with high, medium and low dosage group.Normal saline is a matched group, irritate stomach give isometric(al) normal saline and the basic, normal, high dosage group of anti-being not acclimatized soft capsule group (250,500,1000mg/kg).Continuously gastric infusion is 10 days, respectively to before the mouse stomach and irritate that the feces of 24h carries out aseptic collection, the mice of weighing simultaneously body weight behind the stomach for the last time.Put in the dry sterilization small test tube of the band bead of having weighed collecting feces, weigh again, calculate stool in mice weight, add the sterilization diluent, dilute 10 times, make even suspension, successively 10 times again, increase progressively dilution, select suitable dilution factor, be seeded in respectively on each selective medium, calculate and respectively organize stool in mice specimen flora testing result, the result represents Lg10 with the logarithm of bacterium number in every gram feces
n/ g content, analyzing and processing is carried out in The data t check.
(3) experimental result: anti-being not acclimatized soft capsule mouse intestinal flora detects and the mice body weight is influenced the result and sees Table 1 respectively, table 2
Table 1 mice is taken anti-being not acclimatized soft capsule front and back intestinal microbial population testing result
* compare P＜0.05 before respectively organizing mouse stomach rear intestinal flora and irritating stomach
Before respectively organizing mouse stomach rear intestinal flora and irritate stomach, * compares P＜0.01
Irritate relatively P＜0.05 of stomach rear intestinal flora number with matched group behind the basic, normal, high dosage group of the # mouse stomach
Irritate relatively P＜0.01 of stomach rear intestinal flora number with matched group behind the basic, normal, high dosage group of the ## mouse stomach
By table 1 as seen, data compared before and after control group mice was irritated normal saline, and bacillus bifidus, lactobacillus, enterobacteria, enterococcus, bacillus perfringens quantity do not have significant change, no difference of science of statistics.After will resisting the being not acclimatized soft capsule to give mice with basic, normal, high dosage respectively, low dose group bacillus bifidus and lactobacillus quantity all obviously increase, and significant difference (P＜0.05) is arranged.Middle and high dosage group bacillus bifidus has utmost point significant difference (P＜0.01).Lactobacillus quantity obviously increases (P＜0.05), and enterobacteria, enterococcus, bacillus perfringens quantity quantity do not have significant change.
Mouse stomach is compared with matched group after giving anti-being not acclimatized soft capsule, and the bacillus bifidus quantity of low dose group mice has significant difference (P＜0.05); Middle and high dosage group mice bacillus bifidus quantity has utmost point significant difference (P＜0.01).The lactobacillus of basic, normal, high three dosage group mices is compared with matched group, and significant difference (P＜0.05) is all arranged.Enterobacteria, enterococcus, bacillus perfringens quantity do not have significant change, no difference of science of statistics.
Table 2 mice is taken the variation of anti-being not acclimatized soft capsule front and back body weight
| Group | Dosage (mg/kg) | Body weight (g) before the experiment | Experiment back body weight (g) | Weight gain value (g) | The P value |
| Matched group | Normal saline | 21.35±1.15 | 28.85±1.26 | 7.50±1.54 | --- |
| Low dose group | 250 | 21.43±1.21 | 28.36±1.41 | 6.93±1.28 | ＞0.05 |
| Middle dosage group | 500 | 21.15±0.98 | 28.23±1.95 | 7.08±1.65 | ＞0.05 |
| High dose group | 1000 | 21.29±1.05 | 28.15±1.54 | 6.86±1.75 | ＞0.05 |
By table 2 as seen, beginning to irritate before excess of the stomach tests, it is even that each organizes the mice body weight, there was no significant difference; Behind the continuous irrigation stomach 10 days, compare with matched group, each organizes mice body weight and weight gain value no significant difference, illustrates that taking anti-being not acclimatized soft capsule does not have influence to the mice body weight.
(4) experiment conclusion: anti-being not acclimatized soft capsule can significantly increase the quantity of mouse intestinal bacillus bifidus and lactobacillus, especially can utmost point significance strengthens the quantity of bacillus bifidus.Enterobacteria, enterococcus, bacillus perfringens quantity are not had obvious change, and the mice body weight change is not had influence.Can judge that anti-being not acclimatized soft capsule has the effect that improves microbial population of animal intestinal tract.
2. anti-being not acclimatized soft capsule human body intestinal canal flora test
(1) method for cultivation of bacteria
Bacillus bifidus: 37 ℃ in BBL agar, anaerobism was cultivated in 48～72 hours;
Lactobacillus: 37 ℃ in LBs agar, cultivated in 48 hours;
Enterobacteria: 37 ℃ in EMB agar, cultivated in 24～48 hours;
Enterococcus: 37 ℃ of sodium azide-crystal violets-Esculin agar, cultivated in 24～48 hours;
Bacteroid: 37 ℃ in Bd agar, anaerobism was cultivated in 24 hours;
Bacillus perfringens: 37 ℃ in TSC agar, anaerobism was cultivated in 24 hours;
(2) improve the human body intestinal canal flora test method
Choose the adult experimenter of 60 examples, be divided into 3 groups at random, every group 20 people, the men and women half and half.Before the test-meal given the test agent, the aseptic experimenter's feces of taking, check intestinal microbial population number.Basic, normal, high dosage group experimenter takes 2 of anti-being not acclimatized soft capsules, 4,8 every day respectively, continuous 10 days.Tried thing 3 days, 5 days, 10 days and withdrawn aseptic detection of experimenter's feces and the record intestinal microbial population value taked back 3 days, 5 days, 10 days respectively at taking.Observe, write down the edible front and back of experimenter subjective symptoms simultaneously.
(3) result of the test: after the experimenter takes anti-being not acclimatized soft capsule by basic, normal, high dosage respectively, human body intestinal canal flora change see Table 3, table 4, table 5
Table 3 is taken the anti-being not acclimatized soft capsule flora of low dosage (2) every day and is changed
| Bacterial species | Bacillus bifidus | Lactobacillus | Enterobacteria | Enterococcus | Bacteroid | Bacillus perfringens |
| Before taking | 8.01±1.56 | 7.38±1.17 | 7.28±0.89 | 5.87±1.01 | 8.95±1.73 | 1.89±0.85 |
| Take 3d | 8.57±1.21 | 7.30±0.69 | 7.41±0.54 | 5.89±1.39 | 8.87±1.01 | 1.91±0.82 |
| Take 5d | 9.45±0.84* | 7.55±0.57 | 7.32±0.97 | 5.91±0.85 | 8.76±0.98 | 1.94±0.99 |
| Take 10d | 8.88±0.74 | 7.48±0.66 | 7.31±0.84 | 5.93±1.01 | 8.54±0.75 | 2.01±1.33 |
| Withdraw 3d | 8.81±0.58 | 7.51±0.85 | 7.40±0.82 | 5.98±0.83 | 8.67±0.85 | 2.01±1.15 |
| Withdraw 5d | 8.68±0.65 | 7.33±0.61 | 7.31±1.12 | 5.87±1.18 | 8.56±0.64 | 1.99±1.32 |
| Withdraw 10d | 8.65±0.59 | 7.25±1.14 | 7.16±0.99 | 5.91±0.75 | 8.17±2.01 | 1.89±0.82 |
* take and tried behind the thing to be tried before the thing relatively p＜0.05 with taking
Table 4 is taken the anti-being not acclimatized soft capsule flora of middle dosage (4) every day and is changed
| Bacterial species | Bacillus bifidus | Lactobacillus | Enterobacteria | Enterococcus | Bacteroid | Bacillus perfringens |
| Before taking | 7.61±0.85 | 7.21±0.87 | 6.75±1.26 | 5.21±0.85 | 8.46±1.85 | 2.11±0.57 |
| Take 3d | 9.26±0.59** | 9.15±0.82** | 6.91±0.65 | 5.32±0.88 | 8.54±1.52 | 2.01±1.54 |
| Take 5d | 9.38±0.37** | 9.21±0.56** | 6.82±0.88 | 5.28±1.37 | 8.49±0.85 | 1.85±0.85 |
| Take 10d | 8.91±0.58* | 9.01±0.81* | 6.93±0.65 | 5.01±0.65 | 8.55±1.25 | 1.94±0.87 |
| Withdraw 3d | 8.61±0.75 | 8.42±1.08 | 7.01±0.77 | 5.32±0.89 | 8.65±0.87 | 2.01±1.19 |
| Withdraw 5d | 8.59±0.77 | 8.24±1.21 | 6.85±0.85 | 5.16±0.67 | 8.63±1.19 | 2.12±1.85 |
| Withdraw 10d | 8.61±0.97 | 8.38±0.94 | 6.98±0.95 | 5.64±1.29 | 8.45±0.52 | 1.95±0.99 |
* take and tried behind the thing to be tried before the thing relatively p＜0.05 with taking
* takes and is tried behind the thing to be tried before the thing relatively p＜0.01 with taking
Table 5 is taken the anti-being not acclimatized soft capsule flora of high dose (8) every day and is changed
| Bacterial species | Bacillus bifidus | Lactobacillus | Enterobacteria | Enterococcus | Bacteroid | Bacillus perfringens |
| Before taking | 8.27±0.96 | 7.89±1.37 | 7.54±0.66 | 5.44±0.54 | 8.87±1.25 | 2.14±0.65 |
| Take 3d | 9.18±0.36** | 8.89±0.87** | 7.61±0.91 | 5.51±1.21 | 8.56±0.85 | 2.02±0.82 |
| Take 5d | 9.69±0.52** | 8.91±0.94** | 7.71±0.65 | 5.36±1.01 | 8.46±1.02 | 2.01±0.74 |
| Take 10d | 8.99±0.77* | 8.62±0.85* | 7.68±0.85 | 5.57±0.88 | 8.73±0.99 | 2.13±1.21 |
| Withdraw 3d | 8.68±0.85 | 8.25±1.01 | 7.55±0.51 | 5.58±0.86 | 8.65±1.11 | 2.05±1.52 |
| Withdraw 5d | 8.59±0.76 | 8.17±1.93 | 7.40±0.61 | 5.41±1.66 | 8.85±0.80 | 1.95±0.88 |
| Withdraw 10d | 8.554±0.52 | 8.22±1.21 | 7.54±0.91 | 5.63±0.55 | 8.661±1.25 | 2.01±1.19 |
* take and tried behind the thing to be tried before the thing relatively p＜0.05 with taking
* takes and is tried behind the thing to be tried before the thing relatively p＜0.01 with taking
By table 3,4,5 as can be known, low dose group (obeying 2 of anti-being not acclimatized soft capsules every day), take 5 days after, bacillus bifidus significantly increases, and significant difference (p＜0.05) is arranged; Fruit quantity did not have significant change (p＞0.05) before and after the enterobacteria of low dose group, enterococcus, bacteroid, bacillus perfringens were taken.In dosage group (obeying 4 of anti-being not acclimatized soft capsules every day), took the 3rd day, the 5th day, bacillus bifidus and lactobacillus increase, difference is (p＜0.01) extremely significantly, take 10 days after, bacillus bifidus and lactobacillus still significantly increase (p＜0.05); Fruit quantity did not have significant change (p＞0.05) before and after enterobacteria, enterococcus, bacteroid, the bacillus perfringens of middle dosage group taken.High dose group (obeying 8 of anti-being not acclimatized soft capsules every day) was taken the 3rd day, the 5th day, and bacillus bifidus and lactobacillus increase, and difference is (p＜0.01) extremely significantly, take 10 days after, bacillus bifidus and lactobacillus still significantly increase (p＜0.05); Fruit quantity did not have significant change (p＞0.05) before and after enterobacteria, enterococcus, bacteroid, bacillus perfringens were taken.
Experimental result illustrates the middle and high dosage group of anti-being not acclimatized soft capsule, can significantly increase the quantity of bacillus bifidus and lactobacillus after taking, enterobacteria, enterococcus, bacteroid, bacillus perfringens quantity are not had obvious influence, can judge that thus anti-being not acclimatized soft capsule has the effect of the human body intestinal canal flora of improvement.
The experimenter takes the reaction behind the anti-being not acclimatized soft capsule, and duration of test writes down main suit's symptom of experimenter every day, after the experimenter takes and tried thing, the defecation frequency rule, the feces character is normal, and defecation is unobstructed, no constipation or diarrhoea phenomenon, it is good that diet, sleep and the mental status all keep.
Two, anti-being not acclimatized soft capsule improves the sleep state experiment
1. anti-being not acclimatized soft capsule is to the influence length of one's sleep of pentobarbital sodium inducing mouse
(1) experimental technique: get 40 of one-level Male Kunming strain mice, body weight 20～22g is divided into 4 groups at random, 10 every group.The content of anti-being not acclimatized soft capsule is taken out the back dilution, be mixed with high, medium and low dosage group.Normal saline is a matched group, irritate stomach give isometric(al) normal saline and the basic, normal, high dosage group of anti-being not acclimatized soft capsule group (250,500,1000mg/kg).Gastric infusion is 20 days continuously, last is irritated stomach and is given each treated animal lumbar injection pentobarbital sodium 60mg/kg after 30 minutes, the deep sleep persistent period after observation and the record injected in mice, with the mice righting reflex loss is time for falling asleep, be the length of one's sleep righting reflex loss to recovery time, and calculate the average length of one's sleep of respectively organizing mice.
(2) experimental result: anti-being not acclimatized soft capsule prolongs the inductive mouse sleep time influence of pentobarbital sodium, and experimental result sees 6
The anti-being not acclimatized soft capsule of table 6 is to the inductive mouse sleep time influence of pentobarbital sodium
| Group | Dosage (mg/kg) | Number of animals (only) | The mice average length of one's sleep (min) | The P value |
| Matched group | - | 10 | 98.64±28.75 | - |
| Low dose group | 250 | 10 | 132.55±33.57 | P＞0.05 |
| Middle dosage group | 500 | 10 | 166.81±21.52 | P＜0.05 |
| High dose group | 1000 | 10 | 167.28±35.83 | P＜0.05 |
As shown in Table 6, irritate stomach and give mouse anti being not acclimatized soft capsule, compare with matched group, middle and high dosage group can obviously improve the average length of one's sleep of mice, and significant difference (p＜0.05) is arranged.Low dose group does not have significant change, there was no significant difference (p＞0.05).
2. anti-being not acclimatized soft capsule is to the influence of mice pentobarbital sodium sub-threshold dose sleep incidence rate
(1) experimental technique: mice group and medication are the same, gastric infusion is 20 days continuously, after the last administration 30 minutes, respectively to each group mouse peritoneal injection pentobarbital sodium 25mg/kg, reach more than 1 minute for entering the standard of sleep with the mice righting reflex loss, observe in 30 minutes, each organizes the number of elements that sleep takes place mice, and calculates the sleep incidence rate of respectively organizing mice.
(2) experimental result: anti-being not acclimatized soft capsule is to the influence of mice pentobarbital sodium sub-threshold dose sleep incidence rate, and experimental result sees 7
The anti-being not acclimatized soft capsule of table 7 is to the influence of mice pentobarbital sodium sub-threshold dose sleep incidence rate
| Group | Dosage (mg/kg) | Number of animals (only) | Sleeping number of animals (only) | Mice sleep incidence rate (%) | The P value |
| Matched group | - | 10 | 1 | 10 | - |
| Low dose group | 250 | 10 | 3 | 30 | P＞0.05 |
| Middle dosage group | 500 | 10 | 5 | 50 | P＜0.05 |
| High dose group | 1000 | 10 | 5 | 50 | P＜0.05 |
As shown in Table 7, irritate stomach and give mouse anti being not acclimatized soft capsule, compare with matched group, middle and high dosage group can obviously improve mice pentobarbital sodium sub-threshold dose sleep incidence rate, and significant difference (p＜0.05) is arranged.Low dose group does not have significant change, there was no significant difference (p＞0.05).
By above-mentioned interpretation, improve the sleep incidence rate of mice the average length of one's sleep of anti-being not acclimatized soft capsule energy significant prolongation mice, can judge that anti-being not acclimatized soft capsule has the effect that improves sleep.
Three, anti-being not acclimatized soft capsule is alleviated the mice fatigue experiment
Get 40 of mices, body weight 20～22g, male and female half and half are divided into 4 groups at random.The content of anti-being not acclimatized soft capsule is taken out the back dilution, be mixed with high, medium and low dosage group.Normal saline is a matched group, irritate stomach give isometric(al) normal saline and the basic, normal, high dosage group of anti-being not acclimatized soft capsule (250,500,1000mg/kg).Successive administration 7 days, behind the last administration 30min, take by weighing body weight respectively before the animals administer and after the last administration, the mice body weight 5% of bearing a heavy burden respectively is put in 25 ℃ of water temperatures swimming grooves and swims, record mice power exhausts swimming time (sink under water be as the criterion in 10 seconds with mice), and experimental result sees Table 8
The anti-being not acclimatized soft capsule of table 8 is alleviated the influence of mice fatigue
| Group | Dosage (mg/kg) | Number of animals (only) | Mice swimming time (min) | The P value |
| Matched group | - | 10 | 13.25±5.89 | - |
| Low dose group | 250 | 10 | 23.54±9.58 | P＜0.05 |
| Middle dosage group | 500 | 10 | 25.66±8.24 | P＜0.01 |
| High dose group | 1000 | 10 | 26.17±9.21 | P＜0.01 |
Mouse stomach gives anti-being not acclimatized soft capsule, the mice swimming with a load attached to the body time can obviously be prolonged, compare with the normal saline matched group, there were significant differences for low dose group (P＜0.05), middle and high dosage group has utmost point significant difference (P＜0.01), and the result shows that anti-being not acclimatized soft capsule has the obvious anti-fatigue effect.
Above experimental data shows that anti-being not acclimatized soft capsule can effectively regulate gastrointestinal bacterial flora, improves sleep state and antifatigue effect, has very big value for tourism and short-term strange land work crowd.Anti-being not acclimatized soft capsule adult suggestion dose: specification 0.5g/ grain, warm water takes, every day 2 times, each 2.
Claims (9)
1. the soft capsule of an anti-being not acclimatized, it is characterized in that its content is made of by a certain percentage vegetable oil, oligofructose and suspending agent, wherein the percentage by weight of vegetable oil is 95%-5%, the percentage by weight of oligofructose is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
2. anti-being not acclimatized soft capsule according to claim 1 is characterized in that vegetable oil in the soft capsule is by in Princepia utilis oil, Camellia oil, olive oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil one or several.
3. anti-being not acclimatized soft capsule according to claim 1 is characterized in that described soft capsule can add Rhizoma Zingiberis Recens, Pericarpium Citri Reticulatae, Bulbus Allii, Herba Pogostemonis, Folium Perillae, Fructus Crataegi, Semen Raphani, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Fructus Hippophae, spirulina, Semen Ziziphi Spinosae, Margarita powder, Fructus Amomi, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Lycii, Fructus Mori, Arillus Longan, Radix Puerariae, Poria, Flos Caryophylli, Semen Cassiae, Fructus Cannabis, Herba Houttuyniae, Radix Glycyrrhizae, Semen Arecae, Rhizoma Coptidis, the Radix Astragali, Flos Carthami, green tea, Radix Panacis Quinquefolii, Ganoderma, Folium Ginkgo, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Semen Sesami, Herba Cistanches, Radix Et Rhizoma Rhei, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Colla Corii Asini, dietary fiber, oligosaccharide, probiotic bacteria, lactobacillus, isomerized lactose, calcium lactate, polydextrose, chitosan, melatonin, in the vitamin E one or several.
4. according to the described anti-being not acclimatized soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 95%-5%, and the percentage by weight of oligofructose is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
5. according to the described anti-being not acclimatized soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 75%, oligofructose percentage by weight 20%, and Cera Flava percentage by weight 5% is formed.
6. according to the described anti-being not acclimatized soft capsule of claim 1, the content that it is characterized in that soft capsule is a Princepia utilis oil percentage by weight 30%, olive oil percentage by weight 30%, oligofructose percentage by weight 20%, Semen Ziziphi Spinosae extract percentage by weight 15%, Cera Flava percentage by weight 4%, vitamin E percentage by weight 1%.
7. according to the described anti-being not acclimatized soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 60%, oligofructose percentage by weight 10%, Pericarpium Citri Reticulatae extract percentage by weight 10%, Rhizoma Zingiberis Recens extract percentage by weight 5%, Folium perillae extract percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, Cera Flava percentage by weight 5% is formed.
8. according to the described anti-being not acclimatized soft capsule of claim 1, it is characterized in that soft capsule content is by Princepia utilis oil percentage by weight 30%, olive oil percentage by weight 25%, oligofructose percentage by weight 10%, Folium perillae extract percentage by weight 10%, Herba Pogostemonis extract percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, Bulbus Allii extract percentage by weight 5%, soybean phospholipid percentage by weight 5% is formed.
9. according to the described anti-being not acclimatized soft capsule of claim 1, the content olive oil percentage by weight 40% that it is characterized in that soft capsule, Princepia utilis oil percentage by weight 20%, oligofructose percentage by weight 15%, dietary fiber percentage by weight 15%, melatonin percentage by weight 2%, calcium lactate percentage by weight 2%, vitamin E percentage by weight 1%, Cera Flava percentage by weight 5%.
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