CN103705835A - Drug for treating cad pig and preparation method thereof - Google Patents

Drug for treating cad pig and preparation method thereof Download PDF

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CN103705835A
CN103705835A CN201310744845.7A CN201310744845A CN103705835A CN 103705835 A CN103705835 A CN 103705835A CN 201310744845 A CN201310744845 A CN 201310744845A CN 103705835 A CN103705835 A CN 103705835A
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CN103705835B (en
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黄河
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Liuhe Feed Huaian Co ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract

The invention discloses a drug for treating a cad pig and a preparation method thereof. The drug comprises the following raw medicinal materials: pine needles, radix sophorae flavescentis, medlar, straws, bombyx batryticatus, fructus amomi, mangnolia officinalis, caulis spatholobi, diverseleaf fig fruits, rhizoma dioscoreae, chinese prickly ash, folium cortex eucommiae, lemon peel, Chinese date and portulaca oleracea. The drug disclosed by the invention has the advantages of short treatment time, good effect, low toxic action and diseased pig immunity enhancement on the treatment of the cad pig by taking the effects of reinforcing the spleen to promote digestion, tonifying the liver and kidneys and destroying parasites to support health as treatment principles.

Description

Be used for the treatment of medicine of cad pig and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of cad pig and preparation method thereof.
Background technology
Cad pig, is a kind of disease causing due to congenital malnutrition, is commonly called as " little old pig ", " little Lai pig ".Clinical manifestation is that mental status is fair, and it is comparatively normal that diet is wanted, obviously less than normal than brood piglet, also or adolescence and the speed of growth is extremely slow later.This is a recessive loss condition in pig industry, is worth us to pay attention to.The reason that cad pig is caused has multiple: 1, tire is stiff: the offspring's variety deterioration causing due to inbreeding, growth promoter is stagnated, the age of boar is excessive, body constitution is reduced to motherhood under-reserve, or carry out prematurely copulation, breeding stock self dysplasia and cause offspring's dysplasia to form cad pig.2, milk is stiff: milk is stiff.Trophic level because of sow in pregnancy period is low, lacks protein, mineral, trace element and vitamin in daily ration, or sow latent disease development, causes can not absorbing of some nutrient substance, causes fetus congenital malformation, affects the growth day after tomorrow.Or because the nursing of newborn piglet is improper, as not timely fixedly nipple after piglets birth, weak piglet eats less than good nipple, and sow milking capacity is poor in addition, hypogalactia, quality time, causes piglets can not meet nutritional need, growth retardation.3, food is stiff.After weaned piglet, daily ration quality is bad, malnutrition, or be bred as piglet and support with group feeding, and powerhouse eats food more, and weak person eats less than enough material in starvation, forms in the course of time cad pig.4, sick stiff.Piglet suffers from typhoid fever, Hakuri, chronic gastroenteritis, asthma, ascariasis, lung filaricide, Fasciolopsis, acarid, pox and other chronic diseases, hinder Piglet Development, according to clinical statistics, maximum by the caused cad pig ratio of parasite in various diseases, account for 70% ~ 80% ratio.
Pig deadlock is mainly in the piglet of 10～20 kilograms, clinical manifestation: thick disorderly by hair, physique slight of stature, circle belly, sharp hip, jolterhead, back of a bow contracting abdomen, spirit still can, only do not eat long, on average every day, length was less than 50 grams, just reach 20 kilograms 6 the end of month that have.For sick stiff, with the difference of disease clinical manifestation different, as the disease of breathing has cough and asthma symptom; Bad when the pig long-term diarrhea of trouble baby swine paratyphoid and fashion; Suffer from parasite pig and show as anemia, and have the different phenomenon of having a liking for.
The method of western medical treatment cad pig: 1～3 milliliter of every intramuscular injection calcium lactate, 10～15 milliliters of vitamin B1ies, 5～10 milliliters of hydrocortisone, every day 1 time, are used in conjunction a few days.But western medical treatment cad pig curative effect is undesirable, drug residue is large, and the course for the treatment of is long, and cost price is higher.Raiser, in order to pursue market interest, widely applies western medicine cad pig, causes each chemicals severe overweight, thereby causes food-safety problem, has affected the health of consumer.According to the organic conception of Chinese veterinarian's theory and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Chinese veterinarian thinks that to form the reason of cad pig a lot, has congenital factor, as inbreeding or earlier mating, and the reason such as in-pig feeding and management is improper, causes that piglet birth weight is low, viability is poor; Also have posteriority factor, as breast milk deficiency, malnutrition, wean too early, feed supplement not in time, the factor such as nutrition famine and disease, formed different pattern of syndrome: tire is stiff, food is stiff, milk is stiff, disease is stiff.By promoting the circulation of blood dissipating blood stasis, reducing swelling and alleviating pain, stimulating appetite, parasite killing is held up strong treatment cad pig.
Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can strengthen pig immunity, fattens disease pig, cure the rear recurrence that is difficult for, and cost price is low.Therefore, Chinese herbal medicine, having catered to large market demand aspect treatment cad pig disease, is of great practical significance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine that is used for the treatment of cad pig, treatment cad pig can strengthening the spleen and stomach, anthelmintic, extra-nutrition material etc. are carried out because of symptomatic treatment for causing the stiff cause of disease, promote the fattening of pig, this medicine does not have drug residue, can strengthen the immunity of sick pig.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of cad pig, it is characterized in that, described medicine comprises following raw medicinal material: Folium Pini, Radix Sophorae Flavescentis, Fructus Lycii, Caulis et Folium Oryzae, Bombyx Batryticatus, Fructus Amomi, Cortex Magnoliae Officinalis, Caulis Spatholobi, Fructus Fici Heteromo, Rhizoma Dioscoreae, Pericarpium Zanthoxyli, Folium Eucommiae, Fericarpium Citri Limoniae, Fructus Jujubae and Herba Portulacae.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 10-20 weight portion, Radix Sophorae Flavescentis 10-25 weight portion, Fructus Lycii 15-25 weight portion, Caulis et Folium Oryzae 10-20 weight portion, Bombyx Batryticatus 15-30 weight portion, Fructus Amomi 10-20 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Fructus Fici Heteromo 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, Folium Eucommiae 15-20 weight portion, Fericarpium Citri Limoniae 10-15 weight portion, Fructus Jujubae 10-20 weight portion and Herba Portulacae 10-20 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 13-18 weight portion, Radix Sophorae Flavescentis 15-20 weight portion, Fructus Lycii 19-22 weight portion, Caulis et Folium Oryzae 12-17 weight portion, Bombyx Batryticatus 19-27 weight portion, Fructus Amomi 13-18 weight portion, Cortex Magnoliae Officinalis 18-23 weight portion, Caulis Spatholobi 12-17 weight portion, Fructus Fici Heteromo 15-17 weight portion, Rhizoma Dioscoreae 15-18 weight portion, Pericarpium Zanthoxyli 10-13 weight portion, Folium Eucommiae 15-18 weight portion, Fericarpium Citri Limoniae 10-13 weight portion, Fructus Jujubae 16-20 weight portion and Herba Portulacae 10-15 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions and Herba Portulacae 12 weight portions.
Described medicine also comprises Rhizomadioscoreae, Rhizoma Solani tuber osi, Radix Bupleuri and Endothelium Corneum Gigeriae Galli.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 10-20 weight portion, Radix Sophorae Flavescentis 10-25 weight portion, Fructus Lycii 15-25 weight portion, Caulis et Folium Oryzae 10-20 weight portion, Bombyx Batryticatus 15-30 weight portion, Fructus Amomi 10-20 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Fructus Fici Heteromo 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, Folium Eucommiae 15-20 weight portion, Fericarpium Citri Limoniae 10-15 weight portion, Fructus Jujubae 10-20 weight portion, Herba Portulacae 10-20 weight portion, Rhizomadioscoreae 10-17 weight portion, Rhizoma Solani tuber osi 15-20 weight portion, Radix Bupleuri 10-15 weight portion and Endothelium Corneum Gigeriae Galli 10-17 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 13-18 weight portion, Radix Sophorae Flavescentis 15-20 weight portion, Fructus Lycii 19-22 weight portion, Caulis et Folium Oryzae 12-17 weight portion, Bombyx Batryticatus 19-27 weight portion, Fructus Amomi 13-18 weight portion, Cortex Magnoliae Officinalis 18-23 weight portion, Caulis Spatholobi 12-17 weight portion, Fructus Fici Heteromo 15-17 weight portion, Rhizoma Dioscoreae 15-18 weight portion, Pericarpium Zanthoxyli 10-13 weight portion, Folium Eucommiae 15-18 weight portion, Fericarpium Citri Limoniae 10-13 weight portion, Fructus Jujubae 16-20 weight portion, Herba Portulacae 10-15 weight portion, Rhizomadioscoreae 12-15 weight portion, Rhizoma Solani tuber osi 16-18 weight portion, Radix Bupleuri 11-13 weight portion and Endothelium Corneum Gigeriae Galli 15-17 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions, Herba Portulacae 12 weight portions, Rhizomadioscoreae 14 weight portions, Rhizoma Solani tuber osi 17 weight portions, Radix Bupleuri 12 weight portions and Endothelium Corneum Gigeriae Galli 16 weight portions.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of cad pig to comprise the following steps:
Step 1, according to parts by weight, take all raw medicinal materials, be broken into coarse powder, more further pulverize, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching more than 30%, and the fine powder of collecting by sieve obtains fine powder a;
Step 2, by can not the coarse powder by 120 mesh sieves in step 1 dropping into multi-function extractor, extract twice, add for the first time 5-10 and doubly measure ethanol extraction 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate;
Step 3, the filtrate heating of step 3 is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine powder b;
Step 4, fine powder a and fine powder b are mixed to get to drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention be take strengthening the spleen to promote digestion, the liver and the kidney tonifying, parasite killing and held up and strengthen as Therapeutic Principle, has advantages of that treatment time is short, effective, toxic action is little and strengthen disease pig immunity in the treatment of cad pig.
The specific embodiment
Chinese veterinarian thinks, the reason that forms cad pig is a lot, has congenital factor, as inbreeding or earlier mating, and the reason such as in-pig feeding and management is improper, causes that piglet birth weight is low, viability is poor; Also have posteriority factor, as breast milk deficiency, malnutrition, wean too early, feed supplement not in time, the factor such as nutrition famine and disease, formed that different pattern of syndrome is as stiff in tire, food is stiff, milk is stiff, disease is stiff.The present invention be take strengthening the spleen to promote digestion, the liver and the kidney tonifying, parasite killing and is held up and strengthen as Therapeutic Principle, a kind of medicine that is used for the treatment of cad pig is provided, has comprised following raw medicinal material: Folium Pini, Radix Sophorae Flavescentis, Fructus Lycii, Caulis et Folium Oryzae, Bombyx Batryticatus, Fructus Amomi, Cortex Magnoliae Officinalis, Caulis Spatholobi, Fructus Fici Heteromo, Rhizoma Dioscoreae, Pericarpium Zanthoxyli, Folium Eucommiae, Fericarpium Citri Limoniae, Fructus Jujubae and Herba Portulacae.
Folium Pini: bitter, puckery, temperature.Function cures mainly: expelling wind and activating blood circulation, and improving eyesight, calms the nerves, and removing toxic substances is antipruritic.For influenza, rheumatic arthritis, treating swelling and pain by traumatic injury, nyctalopia, hypertension, neurasthenia; External treating chilblain.
Radix Sophorae Flavescentis: property is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment eczema scrotum, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.
Fructus Lycii: modern study, Fructus Lycii has the blood glucose of reduction, lipotropy, and can atherosclerosis.Fructus Lycii is also strengthening the body resistance, and spermatogenesis is mended the good medicine of marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing, building body, slow down aging, evident in efficacy to chronic hepatitis, central serous chorioretinopathy, optic atrophy etc.; Diabetes, pulmonary tuberculosis etc. are also had to good therapeutic effect; To antitumor, protect the liver, the ageing disorders of blood pressure lowering, blood sugar lowering and old people's organ failure has very strong improvement effect.As tonic invigorator treatment suffer from a deficiency of the kidney each disease and hepatorenal disease curative effect excellent, can significantly improve plasma testosterone cellulose content in human body, reach the effect of keeping fit.Modern medicine study shows, Fructus Lycii has obvious inhibitory action to cancer cell in vitro, the immunologic function that can be used for preventing the diffusion of cancerous cell and strengthen human body.
Caulis et Folium Oryzae: sweet, flat.Enter spleen, lung two warps.Function cures mainly: alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, helps digestion long-pending.Control dysphagic, regurgitation, dyspepsia, has loose bowels, stomachache, quenches one's thirst, jaundice, nebulousurine, hemorrhoid, scald.
Bombyx Batryticatus: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.< < herbal classic > >: main pediatric epilepsy scared night cry, go three worms, Mie Hei über, the cloudy infections of man is sick.< < does not record > >: woman's metrorrhagia is red white, and puerperal is bitterly remaining, all skin ulcer cicatrixs of going out.
Fructus Amomi: acrid in the mouth, warm in nature, Fructus Amomi Main Function is in stomach, kidney and the spleen of human body, can circulation of qi promoting seasoning, stomach function regulating is amusing, removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive, < < book on Chinese herbal medicine converges in speech > > to be described: Fructus Amomi, the gentle medicine of warming middle-JIAO also.If the gas of part of the body cavity above the diaphragm housing the heart and lungs stalk is contrary, not, the gas of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is curbed and is not gone up, and middle Jiao's airsetting is poly-and not easypro, with Fructus Amomi, controls it, proves effective the most prompt.So ancient prescription multiplex with antiabortive what also? cover depressed pain, QI rising in reverse order is frequent fetal movement, the pungent perfume (or spice) of this medicine and altering, temperature and not strong, profit and not cutting, and and out of question, unobstructed three warmers, warm row six internal organs, warm lung is amusing, kidney is supported in nourishing the stomach, the Shu Da liver and gall gas of injustice that has some setbacks, so be apt to also antiabortive.Shen Ze executes and says: Fructus Amomi Wen Xinxiang is loose, and preventing or arresting vomiting leads to diaphragm, reaches gas also; Antiabortive relieving distension, reaches middle gas also; Antidiarrheal dysentery, determine renal mass, reach the therapeutic method to keep the adverse QI flowing downwards also.With the same use of the Radix Aucklandiae, control disorder of QI speed especially.
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes the quickening of saliva, gastric secretion, gastrointestinal peristalsis, and has stomach invigorating digestion-aid effect; Resisting pathogenic microbes acting body experiment showed, that Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis outward; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, when lower than muscle relaxant amount, there is obvious hypotensive effect, this effect can not be by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10～15 minutes, and the blood pressure lowering of intramuscular administration is held time and can be reached more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make heart rate accelerate.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Function cures mainly: enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Fructus Fici Heteromo: sweet, sour, temperature.Function cures mainly: stimulating milk secretion is enriched blood.A little less than curing mainly insufficiency of the spleen stomach, wait disease.
Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, the effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.< < Compendium of Materia Medica > > summarizes five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.
Pericarpium Zanthoxyli: pungent, temperature.Return spleen, stomach, kidney channel.Function cures mainly: warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.
Folium Eucommiae: micro-pungent; Warm in nature.Enter liver; Kidney channel.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening; Blood pressure lowering.Main lumbar and back pain; Foot knees soreness is weak; Hypertension.1. calmness, analgesic activity Folium Eucommiae decoct 20g/kg to mouse stomach after 1 hour, 2 hours, 3 hours, the Assay of spontaneous activity of mice obviously reduced, and the most obvious with 2 hours.Hot plate method experiment confirms that mouse peritoneal injection Folium Eucommiae water decoction-alcohol sedimentation liquid 12g/kg can improve mice induced pain threshold, has obvious analgesic activity.2. the effect 2.1. of pair cardiovascular system is significantly increased the effect of coronary flow to action of the heart Folium Eucommiae water decoction-alcohol sedimentation liquid 0.2g to guinea pig isolated heart tool.Rabbits after intravenous note 20g/kg, the ST section that quiet note isoproterenol is caused is raised with T ripple and is changed and there is no antagonism.2.2. after the quiet note Folium Eucommiae of hypotensive effect anesthetized dog and cat water decoction 0.4g/kg, blood pressure declines rapidly, gos up gradually after maintaining 5 minutes; During the above dosage of quiet note 1g/kg, blood pressure is showing and is declining, and can maintain the long period.Alcohol extract also has hypotensive effect, but Amplitude of Hypotensive and hold time all poor than water decoction.The drop test of anesthetized dog and cat all proves, Folium Eucommiae water decoction and alcohol extract repeat Bolos intravenous administration in a short time can produce tachylaxis, and successive administration even can not occur pressure reduction effect 3-4 time.The water decoction of Folium Eucommiae and the quiet note of 65% ethanol extract 6g/kg all can cause that rabbits blood pressure obviously declines.Each composition that the aqueous solution of Folium Eucommiae, alcoholic solution, ethereal solution and process are purified is noted to rabbits after intravenous as saccharide, alkaloid, aucubin, chlorogenic acid, all has hypotensive effect in various degree.3. immunologic function affected to mouse gavaging Folium Eucommiae water decoction-alcohol sedimentation liquid 10g (crude drug)/kg, be used in conjunction 10 days, can suppress 2, delayed hypersensitivity due to 4-dinitrochlorobenzene (DNCB), and the T cell percentage ratio that can resist due to heavy dose of hydrocortisone reduces, can make tumor-bearing mice peripheral blood T cells percentage ratio increase, peritoneal macrophage phagocytic function strengthens, and cellular immunization is shown to the regulating action of two-phase.Mice gavages Folium Eucommiae water decoction 6g/kg every day, and totally 6 days, have and improve the effect that mice engulfs carbon ink grain, it is to carbon granule Cl in Mouse Blood and gavage the 3g/kg Radix Astragali, the effect of Radix Codonopsis group is roughly suitable.Folium Eucommiae water decoction 12g/kg gavages, and mouse macrophage under hydrocortisone effect is engulfed to erythrocytic function and have a significant effect, and phagocytic activity is increased, and shows that the Cortex Eucommiae has the effect of enhancing human body immunity function.4. antiinflammatory action rats gavaged Folium Eucommiae alcohol extract 10g/kg, have inhibitory action, but effect is than a little less than sodium salicylate to Ovum Gallus domesticus album foot is swollen.Rats gavaged Folium Eucommiae water decoction 6g/kg, Ovum Gallus domesticus album foot is swollen and has obvious inhibitory action, can make eosinopenia in peripheral blood, but the eosinophilic granulocyte in the peripheral blood of excision adrenal gland rat is had no to minimizing, illustrate that the effect of Folium Eucommiae depends on adrenal existence.Folium Eucommiae water decoction 10g/kg, administration 5 days, can make Mouse Blood medium-sized lymphocyte percentage rate show and reduce, mouse thymus atrophy childhood; Folium Eucommiae decoct 10g/kg, continuous 8 days, can make plasma cortisol show increased, and can make Vitamin C content in adult rat adrenal tissue reduce.5. on the glycometabolic Folium Eucommiae decoct 10g/kg that affects, every day, gavage was 2 times, was used in conjunction 8 days, can make Mouse Liver glycogen content show and increase, and made blood sugar content also show and raise.6. effect Folium Eucommiae water decoction and the alcohol extract for palace all has inhibitory action to isolated rat uterus, and can the excitation for palace to anti-acetylcholine.7. other act on 10% Folium Eucommiae water decoction by the free drink-service of mice 30 days, have obvious freeze proof effect, can obviously extend the time-to-live of mice at-3 ℃ of temperature.Branch and leaf aqueous extract has lipoid peroxidization resistant.Adopt radioimmunoassay to observe Folium Eucommiae water decoction 10g/kg gavage and can show cAMP and the cGMP level improving in mice plasma.8. the median lethal dose(LD 50) of toxicity Folium Eucommiae water decoction mouse peritoneal injection is 8.64 ± 0.59g/kg.To mouse gavaging Folium Eucommiae water decoction-alcohol sedimentation liquid 40g/kg, serve on 3d, there are no abnormal phenomena every day.Cortex Eucommiae water decoction-alcohol sedimentation liquid 12g/kg, to rat oral gavage, continuous 21 days, also finds no histological change.
Fericarpium Citri Limoniae: acid; Pungent; Micro-hardship; Temperature.Return spleen; Stomach warp.Function cures mainly: circulation of qi promoting; Stomach function regulating; Pain relieving.Main temper is stagnant; Abdominal distention; Inappetence.
Fructus Jujubae: the nutritional labeling Chinese medicine theories such as rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate are thought, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, is the good health nutrient fruit of the patients such as weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Energy circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, red collapsing, leucorrhea, is the good merchantable brand of enriching blood.
Herba Portulacae: acid, cold.Return liver, large intestine channel.Be applicable to dysentery, heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, dermatomycosis, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.< < opens the surely new herbal > > that values greatly: " Herba Portulacae, clothes not white all the year round." < < Bencao Jingshu > >: " and not white all the year round, always say its removing heat from blood benefit blood, disease is removed the merit ear that body is light.”
Medicine of the present invention also comprises Rhizomadioscoreae, Rhizoma Solani tuber osi, Radix Bupleuri and Endothelium Corneum Gigeriae Galli.
Rhizomadioscoreae: sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Function with cure mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.The < < book on Chinese herbal medicine > > that looks for the truth: " enter in drugs for nourishing yin and should give birth to use, entering spleen reinforcing lung medicine should use by parching to brown." " this genus food, though gas is warm and flat, is the moon of spleen reinforcing lung.Can moisten fur, longue meat, sweet in the mouth is held concurrently salty, again can kidney tonifying reinforcing YIN-essence." invigorating the spleen and replenishing QI: Rhizoma Dioscoreae is planted trace element because being rich in 18 seed amino acids and more than 10; and other mineral; so have strengthening the spleen and stomach, tonifying the lung kidney, invigorating the spleen and replenishing QI, spleen invigorating tonify deficiency; the effects such as beneficial essence, beneficial heart and tranquilizing mind of reinforcing the kidney; there be saying of " all kinds of diseases and ailments are reinforced the kidney, controlled to spleen invigorating tonification, taste essence, treats five kinds of strain and seven kinds of impairment " in Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > >.Quench one's thirst and promote the production of body fluid: this Rhizoma Dioscoreae has the effect of the life of quenching one's thirst: Chinese traditional treatment asthenia is quenched one's thirst in (diabetes) prescription often has Rhizoma Dioscoreae single to use, or share with other medicines, and effect is better.Health care: because fresh Rhizoma dioscoreae is rich in multivitamin, aminoacid and mineral, can prevent and treat Human Lipid Metabolism abnormal, and arteriosclerosis, to safeguarding that insulin normal function also has certain effect, there is enhancing body immunity, beneficial heart and tranquilizing mind, rather cough the health-care effects such as Dingchuan, slow down aging.Skin care: Yuan Dynasty taste expert Li Gao says: " control xerosis cutis and moisten it with this thing." Li Shizhen (1518-1593 A.D.) writes: " Rhizoma Dioscoreae can be moistened fur." Rhizoma Dioscoreae is to nourishes rough skin, vigorous and graceful skin care has unique curative effect.Rhizoma Dioscoreae special pharmacological function: the copper ion in Rhizoma Dioscoreae and connective tissue have very big help to human development, vascular system disease is had to obvious curative effects, calcium in Rhizoma Dioscoreae, muscle and tendon injury is damaged to bone, osteoporosis, loss of tooth has high curative effect, chilblain, diabetes, hepatitis, children's's diarrhea, enuresis, baby's dyspepsia, ulcerative stomatitis, pulmonary tuberculosis, the inferior patient of woman in menstrual period band are also had to good curative effect, and using for a long time can be clear-headed and clear-sighted, life lengthening.Control feed desire: in Rhizoma Dioscoreae, be rich in a large amount of protein, vitamin B group, vitamin C, vitamin E, glucose, crude protein aminoacid, bile alkaline, allantoin etc.; Wherein important nutritional labeling Rhizoma Dioscoreae soap is the precursor materials of synthetic estrogen, nourishing YIN and invigorating YANG, strengthens metabolic effect; And phlegmatic temperament of the GL-PP composition containing in fresh tuber, zymigen etc. can be prevented cadiovascular lipidosis, contribute to digestion and the absorption of gastrointestinal.
Rhizoma Solani tuber osi: sweet, flat.Function cures mainly: QI invigorating, spleen invigorating, antiinflammatory.Control parotitis, scald.< < Hunan medicine will > >: " invigorating the spleen and replenishing QI, strengthening the spleen and stomach, antiinflammatory."
Radix Bupleuri: clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Radix Bupleuri begins to be loaded in < < Sheng Nong's herbal classic > >, classifies as top grade.Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction.Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1 ml/ subcutaneous injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes for continuous 5 days, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content also approach normal.
Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.
Embodiment 1 medicine 1
The embodiment of the present invention provides a kind of medicine that is used for the treatment of cad pig, and medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions and Herba Portulacae 12 weight portions.
The medicine of the embodiment of the present invention makes by being prepared as follows method:
Step 1, according to parts by weight, take all raw medicinal materials, be broken into coarse powder, more further pulverize, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching more than 30%, and the fine powder of collecting by sieve obtains fine powder a;
Step 2, by can not the coarse powder by 120 mesh sieves in step 1 dropping into multi-function extractor, extract twice, add for the first time 5-10 and doubly measure ethanol extraction 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate;
Step 3, the filtrate heating of step 3 is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine powder b;
Step 4, fine powder a and fine powder b are mixed to get to drug powder.
Embodiment 2 medicines 2
The embodiment of the present invention provides a kind of medicine that is used for the treatment of cad pig, and medicine is comprised of the raw material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions, Herba Portulacae 12 weight portions, Rhizomadioscoreae 14 weight portions, Rhizoma Solani tuber osi 17 weight portions, Radix Bupleuri 12 weight portions and Endothelium Corneum Gigeriae Galli 16 weight portions.
The medicine of the embodiment of the present invention is made by following preparation method:
Step 1, according to parts by weight, take all raw medicinal materials, be broken into coarse powder, more further pulverize, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching more than 30%, and the fine powder of collecting by sieve obtains fine powder a;
Step 2, by can not the coarse powder by 120 mesh sieves in step 1 dropping into multi-function extractor, extract twice, add for the first time 5-10 and doubly measure ethanol extraction 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate;
Step 3, the filtrate heating of step 3 is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine powder b;
Step 4, fine powder a and fine powder b are mixed to get to drug powder.
Toxicity test
1, acute toxicity test
40 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.The medicine LD50>32.9 crude drug/kg of the mice oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.The clinical drug dosage of the embodiment of the present invention 1 is 4g crude drug/day/head, and piglet body weight is in 20KG, and average dosage is 0.2g crude drug/kg/ day.By weighing machine: the dosis tolerata of the medicine of mice (average weight take 20g) the oral administration gavage embodiment of the present invention 1 is quantity 329 times.Therefore the Acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.The medicine of embodiment 2 of take is object, according to above-mentioned same test method, tests, and result proves that the Acute toxicity of embodiment 2 is low equally, clinical drug safety.
2, long term toxicity test
The medicine of the embodiment of the present invention 1 to mice by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.The medicine that the embodiment of the present invention 1 is described to mice long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.The medicine of embodiment 2 of take is object, according to above-mentioned same test method, test, the medicine that result proves embodiment 2 equally to mice long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.
Clinical trial
(1) laboratory animal
Prolonged and repeated test, in July, 2011 to 2012 year JIUYUE, is carried out in certain pig farm, selects 180 conduct test pigs of cad pig.Showing as of cad pig: thick disorderly by hair, physique slight of stature, circle belly, sharp hip, jolterhead, hogback contracting abdomen, does not only eat long, and part cad pig is also with the symptom of coughing or suffering from diarrhoea.
(2) test method
Using 180 cad pigs as for examination animal, adopt random fashion to be divided into three groups, every group of 60 cad pigs, adopt respectively the medicine (embodiment group 1) of the embodiment of the present invention 1, medicine (embodiment group 2) and the conventional medicament of embodiment 2 are treated.Wherein, embodiment group 1 gavages medicine according to the ratio of 1:8 is soluble in water, each 5g medicine, twice of every day; Embodiment group 2 gavages medicine according to the ratio of 1:8 is soluble in water, each 5g medicine, twice of every day; Conventional medicament is: 1～3 milliliter of every intramuscular injection calcium lactate, 10～15 milliliters of vitamin B1ies, 5～10 milliliters of hydrocortisone, every day 1 time.Test period is 7-15 days.
(3) efficacy determination
Piglet daily gain is (more than 600g/d) obviously, and the mental status is good, and hair color recovers, and is judged to be effective; Piglet daily gain is (more than 100g/d) obviously, and hair color normal is judged to be effectively; Piglet body weight does not have to change (100g/d is following) substantially, and the symptoms such as hair color are recovery, and it is invalid to be judged to be.
(4) result
Can rehabilitation with the medicine 1 of the embodiment of the present invention 1 and embodiment 2 and 60 cad pigs of medicine 2 treatments 7 days, total effective rate is respectively: 88.3% and 91.7%, and 60 piglets for the treatment of of control group, treatment time is longer, within average 15 days, can recover normal, total effective rate is that result is as shown in table 1.
Table 1 therapeutic effect synopsis
Figure 2013107448457100002DEST_PATH_IMAGE001
Data from table 1: compare with matched group, use the Drug therapy cad pig of the embodiment of the present invention 1 and 2, there is therapeutic effect short, the advantage that cure rate is high.
Concrete case
Case 1
5 piglets on pig farm, Liaocheng of Shandong Province, grow to 17kg, no longer become fat, and emaciated physique, thick few by hair, extremity are obviously unable, are evident as the symptom of cad pig.Use the medicine of the embodiment of the present invention 1 to treat, medicine 1 is gavaged according to the ratio of 1:8 is soluble in water, each 5g medicine 1, every day twice, to use continuously after 7 days, 4 piglets all recover normal, body weight rises appreciably, and continues to use two days, and an other piglet also recovers normal.
Case 2
The domestic piglet of Lee had for 3 monthly ages, but wherein two piglets are compared with other piglets of the same age, and health meat is little, by hair slightly less, dry, there is fold in skin, head is large, is evident as the symptom of cad pig.Use the medicine 2 of the embodiment of the present invention 2 to treat, medicine 2 is gavaged according to the ratio of 1:8 is soluble in water, each 5g medicine 2, every day twice, to use continuously after 7 days, two piglets all recover normal, body weight rises appreciably, and treatment forward backward averaging daily gain is about 800g/ days.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. the medicine that is used for the treatment of cad pig, is characterized in that, described medicine comprises following raw medicinal material: Folium Pini, Radix Sophorae Flavescentis, Fructus Lycii, Caulis et Folium Oryzae, Bombyx Batryticatus, Fructus Amomi, Cortex Magnoliae Officinalis, Caulis Spatholobi, Fructus Fici Heteromo, Rhizoma Dioscoreae, Pericarpium Zanthoxyli, Folium Eucommiae, Fericarpium Citri Limoniae, Fructus Jujubae and Herba Portulacae.
2. the medicine that is used for the treatment of cad pig according to claim 1, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 10-20 weight portion, Radix Sophorae Flavescentis 10-25 weight portion, Fructus Lycii 15-25 weight portion, Caulis et Folium Oryzae 10-20 weight portion, Bombyx Batryticatus 15-30 weight portion, Fructus Amomi 10-20 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Fructus Fici Heteromo 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, Folium Eucommiae 15-20 weight portion, Fericarpium Citri Limoniae 10-15 weight portion, Fructus Jujubae 10-20 weight portion and Herba Portulacae 10-20 weight portion.
3. the medicine that is used for the treatment of cad pig according to claim 1 and 2, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 13-18 weight portion, Radix Sophorae Flavescentis 15-20 weight portion, Fructus Lycii 19-22 weight portion, Caulis et Folium Oryzae 12-17 weight portion, Bombyx Batryticatus 19-27 weight portion, Fructus Amomi 13-18 weight portion, Cortex Magnoliae Officinalis 18-23 weight portion, Caulis Spatholobi 12-17 weight portion, Fructus Fici Heteromo 15-17 weight portion, Rhizoma Dioscoreae 15-18 weight portion, Pericarpium Zanthoxyli 10-13 weight portion, Folium Eucommiae 15-18 weight portion, Fericarpium Citri Limoniae 10-13 weight portion, Fructus Jujubae 16-20 weight portion and Herba Portulacae 10-15 weight portion.
4. according to the medicine that is used for the treatment of cad pig described in claim 1-3 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions and Herba Portulacae 12 weight portions.
5. according to the medicine that is used for the treatment of cad pig described in claim 1-4 any one, it is characterized in that, described medicine also comprises Rhizomadioscoreae, Rhizoma Solani tuber osi, Radix Bupleuri and Endothelium Corneum Gigeriae Galli.
6. according to the medicine that is used for the treatment of cad pig described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 10-20 weight portion, Radix Sophorae Flavescentis 10-25 weight portion, Fructus Lycii 15-25 weight portion, Caulis et Folium Oryzae 10-20 weight portion, Bombyx Batryticatus 15-30 weight portion, Fructus Amomi 10-20 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Fructus Fici Heteromo 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, Folium Eucommiae 15-20 weight portion, Fericarpium Citri Limoniae 10-15 weight portion, Fructus Jujubae 10-20 weight portion, Herba Portulacae 10-20 weight portion, Rhizomadioscoreae 10-17 weight portion, Rhizoma Solani tuber osi 15-20 weight portion, Radix Bupleuri 10-15 weight portion and Endothelium Corneum Gigeriae Galli 10-17 weight portion.
7. according to the medicine that is used for the treatment of cad pig described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 13-18 weight portion, Radix Sophorae Flavescentis 15-20 weight portion, Fructus Lycii 19-22 weight portion, Caulis et Folium Oryzae 12-17 weight portion, Bombyx Batryticatus 19-27 weight portion, Fructus Amomi 13-18 weight portion, Cortex Magnoliae Officinalis 18-23 weight portion, Caulis Spatholobi 12-17 weight portion, Fructus Fici Heteromo 15-17 weight portion, Rhizoma Dioscoreae 15-18 weight portion, Pericarpium Zanthoxyli 10-13 weight portion, Folium Eucommiae 15-18 weight portion, Fericarpium Citri Limoniae 10-13 weight portion, Fructus Jujubae 16-20 weight portion, Herba Portulacae 10-15 weight portion, Rhizomadioscoreae 12-15 weight portion, Rhizoma Solani tuber osi 16-18 weight portion, Radix Bupleuri 11-13 weight portion and Endothelium Corneum Gigeriae Galli 15-17 weight portion.
8. according to the medicine that is used for the treatment of cad pig described in claim 1-7 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Folium Pini 16 weight portions, Radix Sophorae Flavescentis 18 weight portions, Fructus Lycii 21 weight portions, Caulis et Folium Oryzae 15 weight portions, Bombyx Batryticatus 22 weight portions, Fructus Amomi 15 weight portions, Cortex Magnoliae Officinalis 21 weight portions, Caulis Spatholobi 15 weight portions, Fructus Fici Heteromo 16 weight portions, Rhizoma Dioscoreae 16 weight portions, Pericarpium Zanthoxyli 11 weight portions, Folium Eucommiae 16 weight portions, Fericarpium Citri Limoniae 12 weight portions, Fructus Jujubae 18 weight portions, Herba Portulacae 12 weight portions, Rhizomadioscoreae 14 weight portions, Rhizoma Solani tuber osi 17 weight portions, Radix Bupleuri 12 weight portions and Endothelium Corneum Gigeriae Galli 16 weight portions.
9. a preparation method for the medicine that is used for the treatment of cad pig as described in claim 1-8 any one, is characterized in that, described preparation method comprises the following steps:
Step 1, according to parts by weight, take all raw medicinal materials, be broken into coarse powder, more further pulverize, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching more than 30%, and the fine powder of collecting by sieve obtains fine powder a;
Step 2, by can not the coarse powder by 120 mesh sieves in step 1 dropping into multi-function extractor, extract twice, add for the first time 5-10 and doubly measure ethanol extraction 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate;
Step 3, the filtrate heating of step 3 is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine powder b;
Step 4, fine powder a and fine powder b are mixed to get to drug powder.
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