CN113925172A - Giant salamander peptide nutritional composition suitable for children - Google Patents
Giant salamander peptide nutritional composition suitable for children Download PDFInfo
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- CN113925172A CN113925172A CN202111357611.8A CN202111357611A CN113925172A CN 113925172 A CN113925172 A CN 113925172A CN 202111357611 A CN202111357611 A CN 202111357611A CN 113925172 A CN113925172 A CN 113925172A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to the technical field of food, and relates to a giant salamander peptide nutritional composition suitable for children, which comprises the effective components of 30-60 parts of giant salamander peptide, 12-20 parts of a wolfberry fruit extract and 8-16 parts of a coix seed extract. After the giant salamander peptide, the wolfberry extract and the coix seed extract are combined for use, the composition generates a synergistic effect, and is particularly suitable for improving the immunity of children.
Description
Technical Field
The invention belongs to the technical field of health-care food, and relates to a giant salamander peptide nutritional composition suitable for children.
Background
The main reason that children are easy to get ill is low immunity of children, and the main reasons comprise that the viscera of children are under developed, so that the digestion and absorption are poor, and nutrient substances cannot be fully utilized by organisms; meanwhile, the spleen is the largest immune organ of a human body, and the weakness of the spleen directly influences the exertion of the functions of the immune system of the body. The proportion of the solitary girls in modern families is greatly increased, many children do not have good dietary structure and dietary habits, are short in monophagia and anorexia, do not pay attention to diet sanitation, and easily cause gastrointestinal flora imbalance by abusing antibiotics after illness, so that the digestion and absorption of various nutrient substances and the normal development of an intestinal mucosa immune system are influenced. The children's own characteristics determine the children's low immunity, and thus, the children are more required to enhance immunity against various diseases.
Giant salamanders are unique rare specialties in China and belong to two types of protected animals in China. According to the reports of the literature, the giant salamander is sweet, flat and light, and has the effects of tonifying qi, nourishing blood, developing intelligence, nourishing and strengthening. Giant salamanders are mainly distributed in streams in the middle and upper reaches of the Yangtze river, the middle and upper reaches of the Zhujiang river and the Hanshui upper reaches. Since the last 90 s, a large number of giant salamander domesticating and breeding enterprises are established in Hunan, Hubei, Shanxi and Guangxi, and the annual breeding capacity reaches 60 thousands of tails. With the development of the culture scale, the intensive processing and utilization of giant salamander resources become an urgent subject related to the continuous development of the giant salamander industry.
Fructus Lycii (fructus Lycii) is dried mature fruit of Lycium barbarum L of Solanaceae, and contains effective components such as Lycium barbarum polysaccharides, betaine, riboflavin, sterol, rutin, and Lycii folium protein, and various amino acids and microelements. The medlar has various health care efficacies, is a dual-purpose food approved by the Ministry of health, and is beneficial to health when being eaten in a proper amount. Wolfberry fruit contains rich carotene, vitamins, Ca, Fe and other essential nutrients, and thus has the function of improving eyesight, and is also called as eyesight improving. Fructus Lycii has effects of improving immunity, preventing and resisting cancer, protecting eyes, reducing blood lipid, and treating hypertension. Modern pharmacy shows that the boxthorn leaf tea can obviously improve and improve the immunologic function and the physiological function of the old, the weak and sick people and some tumor patients, and has the functions of strengthening the body and delaying senility. The microelement germanium in the fructus Lycii tablet can obviously inhibit cancer cells, completely break cancer cells, relieve some toxic and side effects of chemotherapy of cancer patients, prevent leukocyte decrease, and regulate immunity.
The Coix seed is dry mature seed of Coix seed (Coix lacryma-jobi L.var. mayuen (Roman.) Stapf) of Gramineae, is a common traditional Chinese medicine and common food, has sweet, bland and slightly cold nature and taste, and has the effects of promoting water and swelling, invigorating spleen and removing dampness, relaxing muscles and tendons and removing arthralgia, clearing heat and expelling pus and the like. The Coicis semen contains protein and vitamin B as main ingredients1、B2The product has effects of smoothing skin, reducing wrinkle, and eliminating pigmented spot, and can be used for treating speckle, freckle, and pimple, eliminating speckle, moistening skin, promoting metabolism of blood and water, promoting urination, and eliminating edema.
The children of school age need a large amount of nutrient substances to support in the rapid growth and development period, the digestion and absorption of the nutrient substances needed by the children depend on the healthy intestinal function, the comfort of the body of the children is enhanced by improving the intestinal absorption condition and immunity of the children and reducing the protein sensitization, and the energy and the nutrient substances can be better absorbed and utilized only when the body is comfortable. The food for enhancing the immunity of children mainly enhances the quality by strengthening vitamins and minerals, such as high-calcium food, but the food cannot play a great role in promoting the nutrient absorption, and even causes the gastrointestinal burden due to the ineffective absorption.
Disclosure of Invention
The invention aims to provide a nutritional composition which is suitable for children and can enhance the immunity of children.
In view of the above, the present application addresses this need in the art by providing a giant salamander peptide nutritional composition suitable for use in children.
On one hand, the invention relates to a giant salamander peptide nutritional composition suitable for children, which comprises the effective components of 30-60 parts of giant salamander peptide, 12-20 parts of a wolfberry fruit extract and 8-16 parts of a coix seed extract in parts by weight; preferably, the effective components of the composition comprise 43 parts of giant salamander peptide, 17 parts of wolfberry fruit extract and 10 parts of coix seed extract.
Further, the present invention provides a method for preparing the extract of lycium barbarum comprising: removing impurities from fructus Lycii, and cleaning; crushing 1000g of cleaned wolfberry fruits in a freezing crusher, and sieving the crushed wolfberry fruits with a 20-mesh sieve; adding supercritical CO into pulverized fructus Lycii2Extracting for 2.5 hours in an extraction device, and directly collecting an extracting solution at an outlet of an extraction kettle by using a triangular flask; adding 75% ethanol 6 times the medicinal residue, refluxing at 70 deg.C for 4 hr, filtering with 200 mesh silk cloth, and collecting the reflux liquid and residue; concentrating the obtained reflux liquid to obtain a concentrated solution; adding water with the mass 5 times of that of the obtained residue into the obtained residue, decocting for 2 hours, filtering by adopting 200-mesh silk cloth, and collecting an extracting solution; concentrating the obtained extract, and uniformly mixing with the obtained extract and the obtained concentrated solution to obtain mixed liquid medicine; placing the obtained mixed medicinal liquid inDrying under reduced pressure in a reduced pressure drying oven at 55 deg.C for 6 hr to obtain dry extract; pulverizing the obtained dry extract with fluid energy mill, and sieving with 120 mesh sieve to obtain dry extract powder; mixing the dry extract powder for 12 min to obtain fructus Lycii extract.
Further, the present invention provides a method for preparing an extract of coix seed, comprising: decocting 700g of semen Coicis in 10 times of water for 1 hr for 3 times, filtering the decoctions, mixing, concentrating under reduced pressure, and drying to obtain semen Coicis dry extract; pulverizing the obtained dry extract with fluid energy mill, and sieving with 120 mesh sieve to obtain dry extract powder; mixing the dry extract powder for 12 min to obtain Coicis semen extract.
In another aspect, the invention relates to a food product comprising a giant salamander peptide nutritional composition suitable for children and a dietetic acceptable excipient, the food product being suitable for enhancing the immunity of children.
According to the actual application requirement, the giant salamander peptide nutritional composition suitable for children is prepared into tablets, capsules, powder, granules, pills or oral liquid according to the requirements related to food science and the actual requirement by a method known by the technical personnel in the field; preferably, the compositions of the present invention are prepared as a powder.
Compared with the prior art, the invention has the following beneficial effects or advantages:
the giant salamander peptide nutritional composition suitable for children is designed for school-age children, and through the compound use of the giant salamander peptide, the wolfberry fruit extract and the coix seed extract, on one hand, nutrition can be supplemented for children, the immunity of the children is improved, on the other hand, the compound use of the giant salamander peptide, the wolfberry fruit extract and the coix seed extract can be beneficial to the absorption of the nutritional composition by the children, and an excellent synergistic effect is shown.
Detailed Description
The following examples are given to illustrate the technical aspects of the present invention, but the present invention is not limited to the following examples.
Example 1
The embodiment provides an animal test of the giant salamander peptide nutritional composition suitable for children on the improvement of the immunity of weaned rats.
Cleaning the artificially fed giant salamanders, cutting the artificially fed giant salamanders into giant salamander meat blocks of 2-3 cm, taking out, and draining water. The method comprises the following steps of carrying out deodorization treatment on giant salamander meat blocks by using a ginger juice, xylose and citric acid composite solution, wherein the mass fraction of the ginger juice in the composite solution is 8% of the ginger juice, the mass fraction of the xylose is 1% of the ginger juice, the mass fraction of the citric acid is 1% of the xylose, the mass ratio of the composite solution to fish meat is 6:1, the deodorization temperature is 5 ℃, and the deodorization time is 3 hours. And (3) putting the deodorized and drained giant salamander meat blocks into a constant-temperature baking oven at 60 ℃ for baking for 4 hours to obtain dried giant salamander meat, crushing the dried giant salamander meat and sieving the crushed giant salamander meat with a 80-mesh sieve to obtain giant salamander meat powder. Extracting giant salamander meat powder with No. 6 solvent oil to remove fat, and volatilizing the solvent to obtain defatted giant salamander powder; taking a compound enzyme of elastase and papain, wherein the mass ratio of the elastase to the papain is 2:1, the amount of the compound enzyme is 0.05 percent of the degreased giant salamander powder, adding the compound enzyme into hot water of 55 ℃ for pretreatment for 5min, uniformly stirring, filtering, then adding into a system of the degreased giant salamander powder and purified water, wherein the mass ratio of the degreased giant salamander powder to the purified water is 1:2, adjusting the pH value to 6 by adopting a buffer solution in the enzymolysis process, and carrying out enzymolysis for 2h at the temperature of 45 ℃ to obtain an enzymolysis liquid. Centrifuging, placing the enzymolysis liquid into a 4000r/min centrifugal machine for centrifuging for 10min, taking out and filtering. And (4) performing ultrafiltration twice, wherein a membrane for intercepting the molecular weight of 2000 daltons is adopted for the first time, and the intercepted liquid is taken for intercepting the molecular weight of 4000 daltons for the second time to obtain the giant salamander peptide liquid with the molecular weight range of 2000-4000 daltons. And (3) carrying out spray drying on the giant salamander peptide liquid to obtain a powdery substance, namely the giant salamander peptide.
Male SPF-grade SD weaned (birth 21d) rats (50 ± 10g) were randomly divided into 8 groups (blank group, model group, composition group 1, composition group 2, composition group 3, giant salamander peptide control group, wolfberry extract control group, coix seed extract control group) of 15 animals each. The composition groups are divided into 3 groups according to the mass ratio, and in the composition group 1, the composition group 2 and the composition group 3, the mass ratio of the giant salamander peptide to the wolfberry extract to the coix seed extract is 30:12:8, 43:17:10 and 60:20:16 respectively. The composition group 1 is administrated by gavage with a composition of 40mg/kg giant salamander peptide, wolfberry extract and coix seed extract in a mass ratio of 30:12:8, and a solvent is 0.5% sodium carboxymethylcellulose; the composition group 2 is administrated by gavage with a composition of 40mg/kg giant salamander peptide, the wolfberry fruit extract and the coix seed extract in a mass ratio of 43:17:10, and a solvent is 0.5% sodium carboxymethylcellulose; the composition group 3 is administrated with a composition with the mass ratio of 40mg/kg giant salamander peptide, the medlar extract and the pearl barley kernel extract of 60:20:16 by intragastric administration, and the solvent is 0.5 percent sodium carboxymethylcellulose; gavage of the giant salamander peptide control group is performed with 40mg/kg of giant salamander peptide, and the solvent is 0.5% of sodium carboxymethylcellulose; the fructus Lycii extract control group is administered with 40mg/kg fructus Lycii extract by intragastric administration, and solvent is 0.5% sodium carboxymethylcellulose; the contrast group of the coix seed extract is administered with 40mg/kg of the coix seed extract by intragastric administration, and the solvent is 0.5 percent of sodium carboxymethylcellulose; the model group was gavaged with 0.5% sodium carboxymethylcellulose. The experimental groups (model group, composition group 1, composition group 2, composition group 3, giant salamander peptide control group, wolfberry extract control group and coix seed extract control group) were continuously administered for intragastric administration for 14 days, once a day. 6h after the last administration, the rat body mass is weighed and recorded, the cervical vertebra is killed after leukosis, the spleen and the thymus are taken out in an aseptic mode, and the mass is precisely weighed. Spleen index and thymus index of each group of mice were counted, and are shown in table 1.
TABLE 1 Effect of giant salamander peptide nutritional composition on rat immune organ index
The results in table 1 show that the giant salamander peptide nutritional composition can effectively promote the spleen index and the thymus index of a rat, namely the giant salamander peptide nutritional composition can effectively promote the development of immune organs and improve the immunity of the rat. Compared with the control group with each single dose, the test groups of the compositions 1 to 3 show synergistic effect. All groups of SD rats are subjected to systematic autopsy, no obvious abnormality is found in each organ by visual observation, and no obvious congestion, edema, cell degeneration, necrosis and the like are found under an optical microscope.
Example 2
The embodiment provides a food formula of a giant salamander peptide nutritional composition suitable for children and an animal test for improving the immunity of a weaned rat by using the food.
(1) Food formulation
The food formulation of this example is shown in table 2:
TABLE 2 food formulation table
The preparation method comprises the following steps: the raw materials and the auxiliary materials are prepared into powder and mixed evenly.
According to a food formula table shown in table 2, food 1 (giant salamander peptide 30 parts, wolfberry fruit extract 12 parts, coix seed extract 8 parts, oat flour 1 parts, stevioside 0.01 part), food 2 (giant salamander peptide 43 parts, wolfberry fruit extract 17 parts, coix seed extract 10 parts, oat flour 5 parts, stevioside 0.05 parts), food 3 (giant salamander peptide 60 parts, wolfberry fruit extract 12 parts, coix seed extract 8 parts, sesame powder 10 parts, erythritol 0.1 part) were prepared, respectively. 40g of each of the food 1, the food 2 and the food 3 is taken and respectively prepared into paste by 160ml of warm boiled water. It can be observed that the food is easily dispersed in warm boiled water.
(2) Rat immunity improvement test
SPF grade SD weaning (birth 21d) male rats (50 ± 10g) were randomly divided into 5 groups (blank, model, food 1, food 2, food 3) of 15 animals each. The gavage is performed once for 1 group of food 1 at the rate of 40mg/kg food every day, for 2 groups of food 2 at the rate of 40mg/kg food every day, for 3 groups of food 3 at the rate of 40mg/kg food every day, and for 14 days continuously in the blank group and the model group. Animals in the 5 th, 7 th and 9 th days after the start of the experiment were subcutaneously injected with 100mg/kg cyclophosphamide in the test groups (model group, food 1 group, food 2 group and food 3 group), and the blank group was injected with 100mg/kg physiological saline. 24h after the last administration, the animal picks the eyeball to draw blood, after the blood is coagulated, the serum is centrifugally separated, the serum is firstly diluted by 105 times by buffer solution, IgG and IgM are measured by adopting an ELISA method, and the test results are shown in Table 3.
TABLE 3 changes in IgG and IgM levels in rat serum
The results in table 3 show that the food prepared from the giant salamander peptide nutritional composition suitable for children has an obvious effect of improving the serum IgG and IgM levels of immunosuppressive rats. Therefore, the giant salamander peptide nutritional composition food suitable for children shows an excellent effect in the aspect of improving immunity.
As described above, the present invention can be preferably implemented, and the above-mentioned embodiments only describe the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various changes and modifications of the technical solution of the present invention made by those skilled in the art without departing from the design spirit of the present invention shall fall within the protection scope defined by the present invention.
Claims (6)
1. The giant salamander peptide nutritional composition suitable for children is characterized by comprising, by weight, 30-60 parts of giant salamander peptide, 12-20 parts of a wolfberry fruit extract and 8-16 parts of a coix seed extract.
2. The nutritional composition according to claim 1, wherein the effective components of the composition comprise 43 parts by weight of giant salamander peptide, 17 parts by weight of wolfberry fruit extract and 10 parts by weight of coix seed extract.
3. A food comprising the composition of claims 1-2 and a dietetically acceptable excipient.
4. The food according to claim 3, wherein the food is in the form of tablets, capsules, powders, granules, pills or oral liquids.
5. The food according to claim 3, wherein the food is in the form of powder, and the bromatologically acceptable auxiliary material is one or more of cereal powder and sweetener.
6. The food product of claim 3, wherein the cereal flour is oat flour and/or sesame flour and the sweetener is steviol glycosides and/or erythritol.
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| CN101720933A (en) * | 2009-12-14 | 2010-06-09 | 张家界金鲵生物科技有限公司 | Giant salamander functional food with immune regulation action and preparation method thereof |
| CN103550402A (en) * | 2013-11-21 | 2014-02-05 | 哈药集团中药二厂 | Preparation method for fructus lycii extract |
| CN107951036A (en) * | 2017-11-13 | 2018-04-24 | 凯瑞欧（天津）生物技术有限公司 | A kind of polypeptide product |
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| CN101720933A (en) * | 2009-12-14 | 2010-06-09 | 张家界金鲵生物科技有限公司 | Giant salamander functional food with immune regulation action and preparation method thereof |
| CN103550402A (en) * | 2013-11-21 | 2014-02-05 | 哈药集团中药二厂 | Preparation method for fructus lycii extract |
| CN107951036A (en) * | 2017-11-13 | 2018-04-24 | 凯瑞欧（天津）生物技术有限公司 | A kind of polypeptide product |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114938850A (en) * | 2022-06-08 | 2022-08-26 | 陕西语泽生物医药有限公司 | Giant salamander peptide nutritional composition for promoting growth of children |
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