CN106165885A

CN106165885A - A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing method

Info

Publication number: CN106165885A
Application number: CN201610234257.2A
Authority: CN
Inventors: 王伟
Original assignee: Maanshan Zhicheng Technology Co Ltd
Current assignee: Maanshan Zhicheng Technology Co Ltd
Priority date: 2016-04-17
Filing date: 2016-04-17
Publication date: 2016-11-30

Abstract

The invention discloses a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis of the present invention, be made up of the raw material of following weight portion: Radix Bupleuri 15 parts, Fructus Aurantii 15 parts, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, to fry the Radix Aucklandiae 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 parts, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, the Radix Astragali 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 parts, Herba Pogostemonis 12 parts, 12 parts of Poria, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water appropriate.The invention have the advantage that inventive formulation regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Qinghua are damp and hot, regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis, improves body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue simultaneously.

Description

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing Method

Technical field

The present invention relates to a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, in particular, relate to A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation method thereof technical field.

Background technology

Chronic superficial gastritis be gastric mucosa be the disease of chronic superficial inflammation, for digestive system commonly encountered diseases, belong to chronic One in gastritis.Because being addicted to drink, drink espresso, bile reflux, or can cause because of helicobacter pylori infections etc..Patient can have difference The indigestion symptom of degree, such as epigastric discomfort, dull pain after feed, companion's belch, nauseating, pantothenic acid, occasionally has vomiting.Shallow stomach The scorching specific symptom that lacks, the weight of symptom and the lesion degree of gastric mucosa are the most non-uniform.Most patient is the most asymptomatic or has Indigestion symptom such as upper abdomen dull pain, loss of appetite, post-prandial fullness, the acid regurgitation etc. that degree is different.Individuals patients accompanies mucosal erosion Person's upper abdominal pain is more apparent, and can have hemorrhage.

The traditional Chinese medical science thinks damp and hot by regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Qinghua, and regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis.

For threpsology's angle, chronic superficial gastritis, in addition to taking regular Therapeutic Method and treating, is also wanted Be careful in one's diet treatment, the nutrient that supply is sufficient, reasonably combined dietary structure.The present invention combine just dietetic nutrition regulation and Chinese medicine formula makes a kind of health food granule having and supplementing the nutrients and assist treatment dual-use function, improves human immunity simultaneously Power, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the function of the aspect such as anticancer.

Summary of the invention

The present invention is directed to the deficiency of existing product, and provide one to have extra-nutrition, auxiliary treatment, improve self increase The wriggling of the intestines and stomach, cures the disease and strengthens a kind of nutrient formulation nanometer preventing and treating chronic superficial gastritis of the advantages such as body immunity simultaneously Granule.

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, described nutrient formulation nano-particle is by following former Material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin are processed into；

Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 5-10 part, rice 1-5 part, Semen setariae 1-15 part, Corn starch 5-10 part, fructus zizaniae caduciflorae 1-10 part, Semen Sesami Nigrum 1-10 part, aminoacid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin 0.1-0.5 part；

The prescription of the concentrated liquid of tradition Chinese medicine in described nutrient formulation nano-particle according to weight is: Radix Bupleuri 15 parts, Fructus Aurantii 15 Part, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, the stir-fry Radix Aucklandiae 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 Part, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, the Radix Astragali 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 Part, Herba Pogostemonis 12 parts, 12 parts of Poria, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate；

Described amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, color ammonia Acid 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；

Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein, Several or all mix；Maintain healthy institute required by adding to supplement.

The invention also discloses a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing method, Comprise the following steps；

A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；

B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, Isolated Oleum Vitis viniferae is standby；

C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；

D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed Insoluble matter, obtains Matrix Solution II；

E, the Radix Astragali, Rhizoma Coptidis, Radix Scutellariae, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to 100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats dense under the conditions of 0.05MPa Contracting；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, 30 points Zhong Hou, is filtered alcohol deposit fluid by 0.3um filter, and alcohol deposit fluid obtained above heats under the conditions of 0.04MPa receipts alcohol, Chinese medicine extraction liquid a；

Radix Bupleuri, Fructus Aurantii, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis mix and blend are put into super micron mill, and super micron mill heating keeps 80 degree of 5-6 of temperature Minute, carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；

Take stir-fry the Radix Aucklandiae, Rhizoma Cyperi (processed), Fructus Hordei Germinatus (parched), Fructus Setariae Germinatus (parched), Endothelium Corneum Gigeriae Galli (parched), Semen Coicis (parched), Herb Gynostemmae Pentaphylli, Rhizoma Atractylodis Macrocephalae (parched), Cortex Magnoliae Officinalis, Fructus Gardeniae, Herba Pogostemonis, Poria, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer ,-10～-20 DEG C Freezing 10-20 minute, form freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling are extracted 3 times, adds 2 for the first time Times amount water, temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4 times amount water, and temperature keeps 80-100 DEG C, carries out Infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and insulation is concentrated into former Come the 1/2 of volume, add Chinese medicine extraction liquid a, obtain Matrix Solution III standby；

F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation Liquid；

G, the nutritional labelings such as Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule thick Powder, and within 15 minutes, carry out sterilizing by 100 DEG C of microwave heatings, again granule coarse powder is put into nanometered disposal equipment and carry out pure physics Pulverization process is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out Wet granulation or one-step palletizing preparing granular.

Further: described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate In any one.

Further: the step of the wet granulation in described step G is as follows: in mixer-granulator, to add binding agent system Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, by wet Grain is placed in boiling drier, inlet temperature 45～85 DEG C, is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～ 9.0%；

Further: the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture control System is 4.0%～9.0%.

Rhizoma Steudnerae Henryanae: its rich in proteins, starch, pectin, cellulose, aminoacid, vitamin and several mineral materials, simultaneously the richest Containing selenium element and anthocyanidin, the special health care of the nutritious tool of Rhizoma Steudnerae Henryanae, gal4 amino acid therein is all easily by human body Digest and absorb；Wherein rich in vitamin A can improve the mucomembranous epithelial cell of vision and skin, vitamin C can Making collagen protein normally synthesize, prevent and treat scorbutic generation, anthocyanidin is natural potent free radical scavenger, has common Radix Ipomoeae Nutritional labeling outside, also rich in selenium element, ferrum element and anthocyanidin.

Semen setariae: Semen setariae is also known as Semen setariae, is standing grain ancient times, is the product after millet is shelled.In addition to abundant irony, Semen setariae Also there is protein, compound vitamin B, calcareous, potassium, cellulose etc..Semen setariae is contained within the multiple functional factor useful to property, energy Tonifying YANG, YIN nourishing, aristogenesis.

The rice traditional Chinese medical science thinks that nature and flavor are sweet flat, has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, the strong will of benefit essence and the five internal organs, promoting blood circulation, audition improvement Improving eyesight, be only tired of, quench the thirst, effect of antidiarrheal, it is believed that polyphagia can make us " kept fit color ".

Corn starch is universally acknowledged " gold crop ", and its fat, P elements, the content of vitamin B2 occupy cereal First of；Containing linoleic acid and vitamin E in Semen Maydis flour, cholesterol in human body level can be made to reduce, thus reduce arteriosclerosis Occur；Calcic in Semen Maydis flour, irony are more, can prevent hypertension, coronary heart disease；Modern medicine study shows, has rich in Semen Maydis flour Rich glutathion, this is a kind of anticancer factor, can combine with multiple external chemical carcinogen so that it is lose in human body Go toxicity, then excreted by digestive tract.Containing substantial amounts of lysine in the Semen Maydis flour of corase grind, tumor growth can be suppressed.

Fructus zizaniae caduciflorae is a kind of medicine, the rice of food dual-purpose, belongs to Oryza glutinosa class.Fructus zizaniae caduciflorae .5% Han protein 12, crude fat 2.7-3.8%, Carbohydrate 75-84%, coarse ash 1.7-2%.The vitamin C that lacked containing rice, chlorophyll, anthocyanidin, carotene And the special composition such as cardiotonic glycoside, nutritious, there is good tonic effect.

Semen Sesami Nigrum medicine-food two-purpose, has effects such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, and intestine moistening is dry ", on the one hand is because containing There are high quality protein and abundant mineral, are on the other hand because containing abundant unsaturated fatty acid, vitamin E and preciousness Sesamin and melanin.

Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, dimension Raw element B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin are therein A kind of, several or all mix；Maintain healthy institute required by adding to supplement.

Amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, color ammonia Acid 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；

Radix Bupleuri, acrid in the mouth, hardship, cold nature.Reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever, for cold, fever, cold and heat Contact, distending pain in the chest and hypochondrium.

Fructus Aurantii, regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, weight after dysentery.

Pericarpium Citri Reticulatae, bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Cortex Magnoliae Officinalis, meridian distribution of property and flavor. bitter, pungent, temperature. return spleen, stomach, lung, large intestine channel, warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant. control chest and abdomen painful abdominal mass Full distending pain, regurgitation, vomiting, dyspepsia does not disappears, and phlegm retention is breathed heavily.

Frying the Radix Aucklandiae, the abdominal distention caused by stagnation of QI in spleen and stomach, lack of appetite vomiting, the hypochondriac pain caused for QI stagnation of the liver and galibladder, spleen invigorating disappears Stagnant.The stagnant gas of adjustable gastrointestinal.

Fructus Setariae Germinatus (parched), spleen benefiting and stimulating the appetite, and in help digestion.Control indigestion, distension, have loose bowels, anorexia.

Endothelium Corneum Gigeriae Galli (parched), the gizzard inwall of chicken, there is promoting digestion and invigorating the stomach, effect of arresting seminal emission.

Semen Coicis (parched), property slightly sweet flavor is slightly cold, and has inducing diuresis to remove edema, spleen invigorating to dry, the effect such as clearing away heat and discharging pus.

Herb Gynostemmae Pentaphylli, protecting liver and detoxication, effect of lowering blood pressure and blood fat blood glucose.

The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature;Return spleen, stomach warp;Fragrance matter is soft, can rise and can drop, keep and do not walk to have invigorating the spleen and benefiting QI, Dampness diuretic, strengthening superficial resistance to stop perspiration.

The Radix Astragali, returns lung, spleen, liver, kidney channel.Enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and Wide antibacterial action.

Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication, for damp and hot feeling of fullness, vomit, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, Dysphoria and insomnia.

Radix Scutellariae, has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.

Fructus Gardeniae, hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, stops blooding, subsides a swelling.

Herba Pogostemonis, for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, and hygropyrexia, from the beginning of, asthenia of generating heat, uncomfortable in chest is not relaxed, cold-damp Closing summer-heat, stomachache is vomited and diarrhoea, nasosinusitis headache.

Air Bladder pseudosciaenae seu Acipenser, sweet, flat, nontoxic.Sweet in the mouth, temperature.Enter kidney.The kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence, controls kidney Empty spermatorrhea.

Fructus Vitis viniferae nutritive value is the highest, containing mineral calcium, potassium, phosphorus, ferrum and multivitamin B1, vitamin in Fructus Vitis viniferae B2, vitamin B6, vitamin C and Citrin etc., possibly together with the aminoacid of multiple needed by human body, multiple fruit acid contributes to digestion, Suitably eat a little Fructus Vitis viniferae more, can be good for Pi stomach function regulating, dry and cracked to tongue body, overfatigue is of great advantage and has.

The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, clear Removing dampness heat, regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis.Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, The merit of resisting fatigue.The proportioning of each component is screened by great many of experiments, scientific and reasonable；And whole preparation technology is rationally and medicine carries Take rate efficiency high, the effective ingredient in raw material can be retained well, do not bring any impurity, and sweet mouthfeel into, have no side effect.

The invention has the beneficial effects as follows:

1, the nutrient formulation nano-particle of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has Tongue body of releiving is dry and cracked, lessens fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., to improving body immunity, resisting Aging, eliminating toxin and beautifying the skin, nourishing taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulation human body is raw Reason function.

2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；

3, adding Chinese herbal medicine, to have regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Qinghua damp and hot, and regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis, Improve the functions such as body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.

4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has The highest health care and medical value, life-time service can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and Carry easy to use, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen body immunity simultaneously.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.

Embodiment 1

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, described nutrient formulation nano-particle is by following raw material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water are processed in right amount；

Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 8 parts, 2 parts of rice, Semen setariae 5 parts, corn starch 8 parts, fructus zizaniae caduciflorae 8 parts, Semen Sesami Nigrum 8 parts, 0.1 part of aminoacid, the concentrated liquid of tradition Chinese medicine 5 parts, vitamin 0.1 part；

The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Radix Bupleuri 15 parts, Fructus Aurantii 15 parts, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, Fry the Radix Aucklandiae 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 parts, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, the Radix Astragali 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 parts, Herba Pogostemonis 12 parts, Poria 12 Part, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water fresh Herba Dendrobii appropriate, new 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are fitted Amount；

Described amino acid whose raw material according to weight is: isoleucine 0.02 part, 0.03 part of tyrosine, phenylalanine 0.01 Part, lysine 0.01 part, arginine 0.01 part, histidine 0.01 part, tryptophan 0.01 part, citrulline 0.01 part, ornithine 0.01 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；

Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, whole mixing of biotin And weight portion is identical.

The preparation processing method of a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, comprises the following steps；

D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed Insoluble matter, obtains Matrix Solution II；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to strengthen Blood vessel elasticity, lax blood vessel, increase systemic blood circulation, have certain blood pressure reduction effect；Immune system ability can be strengthened, tool Have strong anti-oxidation, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir Mix to smash and mention anthocyanidin through hydromel, while farthest extracting anthocyanidin, can protect the quality of anthocyanidin.Will Water soluble dietary fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste Normally excrete；Adsorbing various metabolic waste, be allowed to normally excrete, the comprehensive utilization value improving Herba Dendrobii improves simultaneously The human body absorption to Chinese medicine ingredients.

E, the Radix Astragali, Rhizoma Coptidis, Radix Scutellariae, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, heating To 100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution adds under the conditions of 0.05MPa Heat concentrates；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, After 30 minutes, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts Alcohol, obtains Chinese medicine extraction liquid a；

Take stir-fry the Radix Aucklandiae, Rhizoma Cyperi (processed), Fructus Hordei Germinatus (parched), Fructus Setariae Germinatus (parched), Endothelium Corneum Gigeriae Galli (parched), Semen Coicis (parched), Herb Gynostemmae Pentaphylli, Rhizoma Atractylodis Macrocephalae (parched), Cortex Magnoliae Officinalis, Fructus Gardeniae, Herba Pogostemonis, Poria, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer ,-10～-20 DEG C of freezings 10-20 minute, form freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling are extracted 3 times, adds 2 times amount for the first time Water, temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and insulation is concentrated into original body Long-pending 1/2, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；

G, Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule coarse powder, and pass through 100 DEG C of microwave heatings carry out sterilizing for 15 minutes, granule coarse powder is put into nanometered disposal equipment again and carries out pure physical pulverization process It is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out wet method system Grain, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, put by wet granular In boiling drier, inlet temperature 45～85 DEG C, it is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～9.0%.

Comparative example 2

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, processing method and other nutritional labelings with embodiment 1, The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Radix Bupleuri 15 parts, Fructus Aurantii 15 parts, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, stir-fry wood Fragrant 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 parts, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, the Radix Astragali 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 parts, Herba Pogostemonis 12 parts, 12 parts of Poria, fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate；Compare without Air Bladder pseudosciaenae seu Acipenser composition with embodiment 1.

Comparative example 3

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, other nutritional labelings are with embodiment 1, the concentrated liquid of tradition Chinese medicine Prescription according to weight be: Radix Bupleuri 15 parts, Fructus Aurantii 15 parts, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, fry the Radix Aucklandiae 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 parts, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, yellow Stilbene 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 parts, Herba Pogostemonis 12 parts, 12 parts of Poria, 10 parts of Air Bladder pseudosciaenae seu Acipenser, water are appropriate. Compare with embodiment 1 without new fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and the Matrix Solution I being processed into, Matrix Solution II.Processing Preparation method is: E and G of embodiment 1 procedure of processing.

Comparative example 4

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, compare with embodiment 1 without Rhizoma Steudnerae Henryanae, rice, Semen setariae, The nutritional labelings such as corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other are the most same as in Example 1.

Comparative example 5

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, compares without aminoacid, vitamin etc. with embodiment 1 Trace element；Other are the most same as in Example 1.

Comparative example 6

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, compares with embodiment 1: without Rhizoma Steudnerae Henryanae, rice, little Nutritional labeling and the trace element such as aminoacid, vitamin such as rice, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other all with embodiment 1 phase With.

Comparative example 7

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis, compares with embodiment 1: except for the difference that, produces Chinese medicine Concentrated solution, by medical material add water direct boiling method prepare.

Clinical experiment divides three parts:

(1) animal acute toxicity and chronic toxicity experiment:

1, animal acute toxicity test

Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritive powder.

Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.

Method and result:

By each for nutritional granular 50g, adding water, the nutritional granular powder made is stuck with paste.Experiment mice is randomly divided into 7 groups of male and female half and half, 7 kinds of nutritional granular powder of feeding are stuck with paste respectively, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continue to observe 7 days；7 In it, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, eye, mouth, nose, ear and Crissum secretions without exception, without the rotten toe that docks.Respectively from 7 groups select 2 execution, finding of naked eye: the heart, liver, lung, gastric and The important organs such as thymus, no abnormality seen changes, shows that two kinds of these nutritive powders are all without acute toxicity.

2, long-term toxicity test for animals

Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritional granular nutritional granular powder made that adds water is stuck with paste.

Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.

Method and result:

The configuration that 7 kinds of nutritional granular powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100, 50g；Experimental mouse is randomly divided into 7 groups, and the nutritional granular powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days is observed dynamic Thing general toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and The pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；

Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach Deng the most significant change, it is understood that through proved by pathology, 7 kinds of nutritional granular powder are stuck with paste animal without chronic toxicity table Existing.

By two above toxicity test, it was demonstrated that the nutritional granular that the present invention is made by embodiment 1 and comparative example is Safety, have no side effect, can be used to clinical patients is carried out clinical trial.

3, embodiment of the present invention using effect investigation:

(1) investigation method:

1. crowd is used: general population

2. the time is used: 10 days

3. number of users: 100 people

4. using method: the most soaked 500 mL

5. index: gastral cavilty burning pain, feeling of oppression and fullness in the chest and epigastrium, bitter taste mouth sticks, and head heavy sensation of the body, indigestion and loss of appetite noisy, and burning sensation of the anus is defecated not well, little The chronic superficial gastritis clinical symptom disappearance such as the most unfavorable, and mouthfeel is the most sour-sweet for effective；Above-mentioned clinical symptom remission after drinking, Blood sugar level recovers normal, and mouthfeel is the most sour-sweet, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.

(2) survey result

Survey result is shown in Table 1.

Table 1 each embodiment using effect application form

Conclusion:

Be can be seen that by the data of comparative example 2, the ratio of invalid number is compared with embodiment 1, adds 8%, shows Air Bladder pseudosciaenae seu Acipenser In Chinese medicine formula, serve priming return through, the function heightened the effect of a treatment, improve the human body assimilation effect to medicine；Bolus for invigorating kidney and improving, Kidney has the function that Tibetan, main store essential substances, main growth promoter and reproduction are taken the photograph by main department, the liquefaction of main water is thanked.Normal renal function then vital essence fills, The all dirty negative and positive of whole body disease the most prosperous, all disappears；Conversely, as the impact or worn with age of various paathogenic factors, renal function can be caused and lose Often.Owing to Air Bladder pseudosciaenae seu Acipenser is a kind of rich sticking material, containing the nutritional labelings such as profuse protein, vitamin, mineral, institute Have with, fish bubble that the kidney invigorating waist knee joint empty, strong, yin nourishing benefit be smart and the effect of moist skin care.For having a delicate constitution, Kidney-Yin loss, spirit The personage overwork, overworked is the most suitable.

The data compared with embodiment 1 by comparative example 3 can be seen that, without new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, honeybee Honey composition and the Matrix Solution I being processed into, Matrix Solution II；The ratio of invalid number is compared with embodiment 1, adds 7 Times；And the average time of obvious effective rate, compare many 1 day than embodiment 1 and (i.e. felt effective, the average sky of clinical symptom disappearance How count 1 day；This shows that the preparation for processing of the present invention makes the concentrated liquid of tradition Chinese medicine prescription and water soluble dietary fiber and Semen Vitis viniferae Creating the most collaborative pharmacological action between the compositions such as oil, water soluble dietary fiber increases effect of the wriggling of the intestines and stomach and promotes people The body absorption to ingredient, it is ensured that metabolic waste normally excretes, the anthocyanidin additionally contained in Pericarpium Vitis viniferae, white hellebore Alcohol, has strong anti-oxidation, mutation, alleviates the function such as hepatosis, protection cardiovascular, strengthen immune system ability；In with Medicine is associated with raising assimilation effect, improves the mouthfeel of Chinese medicine simultaneously, through the configuration and at utmost ingredient meticulously of the present invention Extraction, traditional Chinese drug inspissation formula of liquid of the present invention and preparation method occur in that beat all technique effect.

Compared with embodiment 1 by the data of comparative example 4 and can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum, the ratio of invalid number is compared with embodiment 1, adds 10 times, and the number of obvious effective rate Also reduced, show the nutritional labeling the concentrated liquid of tradition Chinese medicines such as the Rhizoma Steudnerae Henryanae of the present invention, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum Drug effect between create mutually collaborative pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, Nutritional labeling supplements the necessary energy of human body, reaches balanced nutritious, promotes the health absorption to medicine.

Compared with embodiment 1 by comparative example 5, the trace element such as aminoacid, vitamin；Supplementary needed by human body is wanted Highly important effect is had during nutrient and trace element regulation physiological function, catalysis metabolic adsorption medicine.

The data compared with embodiment 1 by comparative example 6 can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum and the trace element such as aminoacid, vitamin；Inefficiency number nearly 15 times and effective percentage number Also nearly 20% is declined；And the average time of obvious effective rate, compare many 4 days than embodiment 1 and (i.e. felt effective people, clinical condition The average time that shape disappears is many 4 days；Illustrate nutritional labeling and trace element human body medicine absorb during played and Its important synergism, greatly promotes human body and recovers medicine and the absorption of nutrition, quickening human body.

The data compared with embodiment 1 by comparative example 7 can be seen that, medical material adds water direct boiling method and the present invention Chinese medicine preparation method compare, the preparation method of the present invention, the extraction of drug effect is far longer than traditional adding water and directly boils Method, the extraction degree of active ingredient has had huge raising.

In sum, the preparation of a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis that the present invention provides adds Work method, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Qinghua are damp and hot, and regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis and nutritional labeling is mutual Collaborative pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, and it is necessary that nutritional labeling supplements human body Energy, reach balanced nutritious, promote the health absorption to medicine, all raw materials are all from medicine-food two-purpose natural plants, nontoxic Side effect.

The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims

1. the nutrient formulation nano-particle preventing and treating chronic superficial gastritis, it is characterised in that described nutrient formulation nanometer Grain is by following raw material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water It is processed in right amount；

The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Radix Bupleuri 15 parts, Fructus Aurantii 15 parts, Pericarpium Citri Reticulatae 15 parts, Cortex Magnoliae Officinalis 15 parts, Fry the Radix Aucklandiae 15 parts, Rhizoma Cyperi (processed) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Fructus Setariae Germinatus (parched) 15 parts, Endothelium Corneum Gigeriae Galli (parched) 15 parts, Semen Coicis (parched) 30 parts, Herb Gynostemmae Pentaphylli 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, the Radix Astragali 30 parts, Rhizoma Coptidis 6 parts, Radix Scutellariae 9 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 9 parts, Herba Pogostemonis 12 parts, Poria 12 Part, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.

A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis the most according to claim 1, it is characterised in that Described amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, phenylpropyl alcohol ammonia Acid 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, tryptophan 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 Part, Valine 0.01 part.

3. the preparation processing method of the nutrient formulation nano-particle preventing and treating chronic superficial gastritis, it is characterised in that include Following steps；

The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis the most according to claim 3 Method, it is characterised in that described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate In any one.

The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis the most according to claim 3 Method, it is characterised in that the step of the wet granulation in described step G is as follows: add binding agent system in mixer-granulator Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, by wet Grain is placed in boiling drier, inlet temperature 45～85 DEG C, is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～ 9.0%。

The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis the most according to claim 3 Method, it is characterised in that the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture Control 4.0%～9.0%.