CN102327593A - Medicament for treating chronic superficial gastritis and preparation method thereof - Google Patents
Medicament for treating chronic superficial gastritis and preparation method thereof Download PDFInfo
- Publication number
- CN102327593A CN102327593A CN201110294586A CN201110294586A CN102327593A CN 102327593 A CN102327593 A CN 102327593A CN 201110294586 A CN201110294586 A CN 201110294586A CN 201110294586 A CN201110294586 A CN 201110294586A CN 102327593 A CN102327593 A CN 102327593A
- Authority
- CN
- China
- Prior art keywords
- rhizoma
- processed
- medicament
- chronic superficial
- superficial gastritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention belongs to the technical field of Chinese patent medicines, and particularly relates to a medicament for treating chronic superficial gastritis and a preparation method thereof. By the medicament, the defect that atrophic gastritis is caused and relapses easily, the defect of poor curative effect and the like in the conventional medicament for treating chronic superficial gastritis are overcome. In the technical scheme, the medicament for treating chronic superficial gastritis comprises the following Chinese herbal medicines: szechuan tangshen root, largehead atractylodes rhizome, tangerine peel, pinellia tuber, lesser galangal rhizome, nutgrass galingale rhizome, ginger, immature bitter orange, officinal magnolia bark, scorch-fried areca, rotating Jerusalem sage and honey-fried liquoric root. The medicament has the advantages of definite curative effect, low cost, no toxic or side effect and the like, and comprehensively conditions a human body; and by the medicament, chronic superficial gastritis cannot relapse easily.
Description
Technical field
The invention belongs to the Chinese Traditional Medicines technical field, be specifically related to a kind of medicine of treating chronic superficial gastritis and preparation method thereof.
Background technology
Chronic superficial gastritis is the non-atrophic chronic inflammatory disease that gastric mucosa is taken place under various paathogenic factor effects, and its prevalence is high, accounts for 80%～90% of patients with gastric disease, and its sickness rate raises with age growth.Can disturb patient's daily life, diet and work during the chronic superficial gastritis outbreak, have a strong impact on patient's quality of life and physical and mental health, if do not treat the danger of cancerating in addition timely and effectively.Western medicine should disease still not have specific medicament at present, can only carry out anti-inflammation and sterilization targetedly to it, and take for a long time and possibly cause atrophic gastritis, and therapeutic effect is not obvious, was prone to repeatedly.
The traditional Chinese medical science thinks that this disease mainly is that spleen rises due to stomach falls, taste one void, and the therefore imbalance of then going up and down promptly, clear QI failing to ascend, turbid QI failing to descend, mechanism of qi stasis for it are not smooth, and gas stops then that blood stops, and with the passing of time then gives birth in the blood stasis; Insufficiency of the spleen then water paddy can not fortune, and then endogenous dampness is by life; Insufficiency of the spleenly also be prone to experience exogenous damp, promptly old nothing select discuss " inside and outside feel, all damp is taken advantage of and attacked it by deficiency-weakness of spleen-QI "; So weakness of the spleen and stomach, then excessive phlegm stops in wetting, and insufficiency of the spleen inability of food and drink to be digested and transported is precise and tiny; Then stop in the diet, burnt in the stagnation of QI, phlegm-damp, food stagnation, the stagnation of blood stasis, stagnation of QI and blood may bring about pain; Cause stomachache to take place, with the passing of time deficient, the stomach internal organs loses in honor and supports.Therefore the traditional Chinese medical science is divided into syndrome of deficiency of spleen qi and stomach qi, syndrome of deficient cold of spleen and stomach, syndrome of incoordination between liver and stomach, syndrome of dampness-heat of spleen and stomach and five kinds of pattern of syndrome of deficiency of stomach-Yin card with this disease.Wherein the primary symptom of syndrome of deficient cold of spleen and stomach is: 1. stomachache is indistinct, endlessly continuous; 2. like warm pain relieved by pressing, tired or suffer from cold after show effect or increase the weight of; Inferior disease is: 1. general vomiting watery fluid; 2. Mental fatigue is indigestion and loss of appetite, the extremity asthenia; 3. hands and feet being not warm, big loose stool is thin; 4. pale tongue with white fur; 5. deficient and weak pulse.
Summary of the invention
The medicine that the present invention is primarily aimed at present treatment chronic superficial gastritis has the initiation of being prone to atrophic gastritis, is prone to repeatedly deficiencies such as unsatisfactory curative effect; And a kind of determined curative effect is provided; Comprehensively regulating, the treatment back is difficult for recurrence and cheap, the medicine of the treatment chronic superficial gastritis that has no side effect.
The present invention also provides the method for preparing of this medicine.
The present invention for realizing the technical scheme that above-mentioned purpose is taked is:
A kind of medicine of treating chronic superficial gastritis is to be crude drug with following parts of medicines by weight:
1～5 part of Radix Codonopsis, 1～5 part of the Rhizoma Atractylodis Macrocephalae, 1～5 part of Pericarpium Citri Reticulatae, 1～3 part of the Rhizoma Pinelliae, 3～9 parts of Rhizoma Alpiniae Officinarums, 3～9 parts of Rhizoma Cyperis, 3～9 parts in Rhizoma Zingiberis Recens, 1～5 part of Fructus Aurantii Immaturus, 1～5 part of Cortex Magnoliae Officinalis, 1～5 part of Semen Arecae Prepareta, 1～5 part of Radix Lamiophlomidis Rotatae, 1～3 part of Radix Glycyrrhizae Preparata.
The method for preparing of medicine that the present invention treats chronic superficial gastritis is following:
Get the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Rhizoma Cyperi and the Fructus Aurantii Immaturus of above-mentioned weight portion earlier, according to conventional method the Rhizoma Atractylodis Macrocephalae is processed Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae is processed Rhizoma Pinelliae, and Rhizoma Cyperi is processed Rhizoma Cyperi (processed with vinegar), and Fructus Aurantii Immaturus is processed Fructus Aurantii Immaturus (parched); It is 60～80% alcohol reflux 2～3 times that the Cortex Magnoliae Officinalis of getting above-mentioned weight portion again adds 6～10 times of amount mass fractions, each 2～3 hours, extracting solution reclaim ethanol to do not have alcohol distinguish the flavor of the Cortex Magnoliae Officinalis clear paste; Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi (processed with vinegar), the Rhizoma Zingiberis Recens four Chinese medicine of getting above-mentioned weight portion add 3～5 times of water gaging distillating extracting oils; With inclusion essential oil, medicinal liquid is put in addition with the beta cyclodextrin of 6～10 times of amounts of volatile oil weight, and the Radix Codonopsis of medicinal residues and above-mentioned weight portion, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Fructus Aurantii Immaturus (parched), Semen Arecae Prepareta, Radix Lamiophlomidis Rotatae and Radix Glycyrrhizae Preparata seven flavor medicine add 8～12 times decocting and boil 2～3 times; Each 2～3 hours; Collecting decoction and above-mentioned medicinal liquid, through 250～350 order centrifugal filtrations, be condensed into temperature when being 65 ℃ relative density be 1.35～1.38 clear paste; Mix and vacuum drying with the Cortex Magnoliae Officinalis clear paste, be ground into extract powder; Get extract powder, volatile oil clathrate compound and 0.1～0.5 part of lactose and 0.0001～0.0002 part of Aspartane mix homogeneously, process granule, packing is processed behind the sterilizing.
Chronic superficial gastritis is this with the weakness of the spleen and stomach, accompanies the stagnation of QI, blood stasis, wet resistance, food stagnation, is principal agent with the sugariness in the treatment; With the diffusing Wen Tongwei accessory drugs of suffering; So be monarch with the Radix Codonopsis in the prescription of the present invention, Radix Codonopsis property is flat, sweet in the mouth, little acid; Return spleen, lung meridian, have the effect of invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness; With Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Fructus Aurantii Immaturus, hot the loosing of Cortex Magnoliae Officinalis is minister, and Rhizoma Alpiniae Officinarum is hot, has warming stomach for dispelling cold, and effects such as pain relieving help digestion; The hot little hardship of Rhizoma Cyperi is sweet, goes into liver, tri-jiao channel, has effects such as soothing the liver circulation of qi promoting, Rhizoma Alpiniae Officinarum and Rhizoma Cyperi share can dispel except that trembling with fear strongly fragrant, enhancing treatment effect; The Cortex Magnoliae Officinalis acrid in the mouth is warm in nature, has the effect of cold expelling, removing dampness, circulation of qi promoting concurrently, is the key medicine of treatment stagnation of cold-damp card; Fructus Aurantii Immaturus is bitter, hot, cold, and for controlling the key medicine of big distention and fullness in the abdomen, Fructus Aurantii Immaturus and Cortex Magnoliae Officinalis are share the effect of playing warming middle-JIAO to promote flow of QI, alleviating distention in middle-JIAO pain relieving altogether; Because of weakness of the spleen and stomach is prone to accompany damp, so use Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, the gas that principal drug assistance strengthens the spleen and stomach improves the lack of appetite distension, fatigue and weakness, the symptoms such as rare pool of defecating; Pericarpium Citri Reticulatae gas perfume (or spice) is warm in nature, and the hot hardship of loosing is fallen, be longer than regulate the flow of vital energy stagnant, and taste, dampness is evil, relieving distension is full; The hot warm-dryness syndrome of the Rhizoma Pinelliae looses, and the hot hardship of loosing is fallen, can dampness and turbid, the regulating the stomach and sending down the abnormal ascending QI of reducing phlegm, for controlling the key medicine of damp-phlegm; The Rhizoma Zingiberis Recens acrid in the mouth is warm in nature, the sun of manageing it and the gas that looses, stomach function regulating and sending down the abnormal ascending QI, and the Rhizoma Pinelliae and Rhizoma Zingiberis Recens have share drying dampness to eliminate phlegm, the merit of normalizing the stomach by guiding QI downward; This patient is prone to that food stagnation is arranged, with the Semen Arecae Prepareta removing food stagnancy therapeutic method to keep the adverse QI flowing downwards; " pathogen usually intruding into collateral in protracted disease ", but the Radix Lamiophlomidis Rotatae blood circulation promoting and blood stasis dispelling used, for gastralgia good analgesic effect is arranged; Radix Glycyrrhizae Preparata is in order to invigorating the spleen and replenishing QI, and relieving spasm to stop pain is in harmonious proportion the property of medicine.
For further showing the therapeutic effect of medicine of the present invention, done following clinical verification:
The patient chooses:
80 chronic superficial gastritis spleen-stomach deficiency-cold patients of hospital outpatient picked at random, be divided into two groups by the table of random number method, matched group 40 examples, male's 24 examples wherein, women's 16 examples, year mean age (59.4 ± 7.8); 40 examples are organized in treatment, male's 23 examples wherein, and women's 17 examples, in year mean age (58.5 ± 11.4), two groups of patients do not have significance meaning (P＜0.05) in sex, age distribution through statistical procedures difference, have comparability.
Diagnostic criteria:
The chronic superficial gastritis diagnostic criteria: 1. with repeatedly or persistence epigastric discomfort, glutted, dull pain, burning pain, the feed postemphasis, companion's belch, acid regurgitation, feel sick, clinical manifestation or companion's epigastrium tenderness such as poor appetite; 2. chronic active inflammation sign is pointed out in gastroscopy and gastric mucosa biopsy; 3. liver-gallbladder disease and pancreas disease etc. are got rid of in B ultrasonic and other inspections (like CT).
Chronic superficial gastritis syndrome of deficient cold of spleen and stomach diagnostic criteria: primary symptom: 1. stomachache is indistinct, endlessly continuous; 2. like warm pain relieved by pressing, tired or suffer from cold after show effect or increase the weight of; Inferior disease: 1. general vomiting watery fluid; 2. Mental fatigue is indigestion and loss of appetite, the extremity asthenia; 3. hands and feet being not warm, big loose stool is thin; 4. pale tongue with white fur; 5. deficient and weak pulse.
Include standard in: 1. meet the patient that chronic superficial gastritis diagnostic criteria and Chinese medical discrimination are chronic superficial gastritis Deficiency and coldness of spleen and stomach pattern of syndrome; 2. the age is at 18-70 between year; When 3. going to a doctor and go to a doctor and do not use any Western medicine in preceding 30 days, and be ready to cooperate the patient of this research.
Exclusion standard: 1. do not meet and include standard person in; 2. be in trimester of pregnancy, age of sucking person; 3. merge primary diseases such as serious hepatic and kidney function obstacle, cardiovascular and cerebrovascular disease, blood system, and spiritedness medical history person; 4. this medicine composition there is allergies person; 5. can not accept gastroscopy person, esophagostenosis, peptic ulcer, esophagus and gastric tumor person are arranged.
The rejecting standard: one of following situation is arranged for rejecting case: 1. occurring other serious concurrent diseases or state of an illness rapid deterioration in the experimentation need take emergent management measure person; 2. due to illness feelings need not accomplished therapist; 3. do not accomplish the scale person of filling in because of a variety of causes.
Therapeutic Method
The treatment group: medicine of the present invention, every day three times, each one bag, every bag of 8g takes after mixing it with water after the meal.
Matched group: because of the chronic superficial gastritis doctor trained in Western medicine does not have specific drug, and this research therapeutic test group employing Chinese traditional treatment scheme, should be according to similar comparable generally acknowledged effectively contrast principle, so adopt generally acknowledged efficacious therapy medicine Xiangsha Liujunzi decoction (medicine composition: Radix Codonopsis 15g; Rhizoma Atractylodis Macrocephalae 30g, Poria 30g, Radix Glycyrrhizae Preparata 10g, Pericarpium Citri Reticulatae 15g Rhizoma Pinelliae 15g; Fructus Amomi 15g, Radix Aucklandiae 10g, Rhizoma Zingiberis Recens 6g) as contrast, usage: Xiangsha Liujunzi decoction; Every day three times, each 100mL, oral after the meal.
4 weeks were 1 course of treatment, 4 weeks did evaluation respectively before the treatment with after the medication, before the treatment, further consultation and fill in CRF when following up a case by regular visits to.
All experimenters all must not merge medicine that uses any other treatment superficial gastritis and the medicine that possibly influence clinical efficacy and untoward reaction evaluation at duration of test.
Observation index
Safety observation: 1. health check-up project; 2. blood, urine, stool routine chemical examination; 3. the heart, liver, kidney function test.
Cardinal symptom therapeutic evaluation standard:
The record of cardinal symptom (glutted after the meal discomfort, full sense morning, epigastrium pain) is pressed the calculating of doing well,improving percentage rate with evaluation; Total mark * 100%, wherein (recovery from illness case load+produce effects case load)/case sum * 100%=total effective rate before doing well,improving percentage rate=(total mark before the treatment～treatment back total mark)/treatment.Specifically be divided into five grades, 1. recovery from illness: transference cure; 2. produce effects: doing well,improving percentage rate>=80%; 3. progressive: 50%≤doing well,improving percentage rate＜80%; 4. invalid: doing well,improving percentage rate＜50%; 5. worsen: doing well,improving percentage rate negative value;
The therapeutic effect of syndrome evaluation criteria:
Adopt the nimodipine method to calculate, integration * 100% before therapeutic index=(integration after integration before the treatment～treatment)/treatment specifically is divided into four grades, 1. clinical recoveries: cardinal symptom, sign disappear or basic disappearance, therapeutic index>=95%; 2. produce effects: cardinal symptom, sign are obviously improved, 70%≤therapeutic index＜95%; 3. effective: cardinal symptom, sign are clearly better, 30%≤therapeutic index＜70%; 4. invalid: cardinal symptom, sign do not have obvious improvement, even increase the weight of therapeutic index＜30%.
Gastric mucosa efficacy evaluation under the scope:
Respectively erythema, erosion, situation hemorrhage and bile reflux under the gastroscope are added up, calculate under each single mirror performance improve grade and total mark is improved degree, specifically divide four grades: 1. recovery from illness: gastric mucosa is normal; 2. produce effects: the gastric mucosal lesions integration reduces more than 2 grades; 3. effective: the gastric mucosal lesions integration reduces 1 grade; 4. invalid: gastric mucosal lesions does not have change or increases the weight of.
Statistical method
Use the SPSS13.0 statistical analysis software, adopt X
2The check therapeutic outcome.
Therapeutic outcome
The traditional Chinese medical science is mainly demonstrate,proved marquis's curative effect
After around treatment group and matched group are treated respectively, the total effective rate of glutted after the meal discomfort, full sense morning, three aspects of epigastrium pain is following: 1. glutted after the meal discomfort: treatment group 85%, matched group 87.5%; 2. early full sense: treatment group 82.5%, matched group 82.5%; 3. epigastrium pain: treatment group 97.5%, matched group 80%; The result shows two groups of glutted after the meal discomforts to the patient, early full sense, epigastrium pain all have obvious therapeutic effect; Wherein in that the glutted curative effect that do not accommodate aspect the early full sense is similar after the meal; No difference of science of statistics; Obviously be superior to matched group in treatment group aspect the epigastrium pain, concrete outcome is seen table 1, table 2 and table 3.
Table 1: glutted after the meal discomfort
Table 2: early full sense
Table 3: epigastrium pain
Inflammation integration under the gastroscope
After treating for 4 weeks, the patient is made gastroscope, with patient's gastroscope contrast before the medication, treatment group and matched group have 8 to refuse the row gastroscopy with 7 patients respectively, so item contrasts its eliminating.Total effective rate compares under treatment group and the matched group patient gastroscope, treatment group 81.25%, and matched group 78.79%, through statistical procedures, the total effective rate zero difference.(specifically seeing table 4)
Table 4: the gastroscope lower integral improves
Clinical observation shows: medicine of the present invention has good and clinical curative effect to the treatment chronic superficial gastritis, especially aspect treatment epigastrium pain, special advantages is arranged, and drug price of the present invention is cheap, has no side effect.
The specific embodiment
Embodiment 1
A kind of medicine of treating chronic superficial gastritis is that the medicine with following weight is a crude drug:
1 kilogram of Radix Codonopsis, 1 kilogram of the Rhizoma Atractylodis Macrocephalae, 1 kilogram of Pericarpium Citri Reticulatae, 1 kilogram of the Rhizoma Pinelliae, 3 kilograms of Rhizoma Alpiniae Officinarums, 3 kilograms of Rhizoma Cyperis, 3 kilograms in Rhizoma Zingiberis Recens, 1 kilogram of Fructus Aurantii Immaturus, 1 kilogram of Cortex Magnoliae Officinalis, 1 kilogram of Semen Arecae Prepareta, 1 kilogram of Radix Lamiophlomidis Rotatae, 1 kilogram of Radix Glycyrrhizae Preparata.
Concrete method for preparing is:
Get the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Rhizoma Cyperi and the Fructus Aurantii Immaturus of above-mentioned weight earlier, according to conventional method the Rhizoma Atractylodis Macrocephalae is processed Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae is processed Rhizoma Pinelliae, and Rhizoma Cyperi is processed Rhizoma Cyperi (processed with vinegar), and Fructus Aurantii Immaturus is processed Fructus Aurantii Immaturus (parched); It is 60 alcohol reflux 2 times that the Cortex Magnoliae Officinalis of getting above-mentioned weight portion again adds 6 times of amount mass fractions, each 3 hours, extracting solution reclaim ethanol to do not have alcohol distinguish the flavor of the Cortex Magnoliae Officinalis clear paste; Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi (processed with vinegar), the Rhizoma Zingiberis Recens four Chinese medicine of getting above-mentioned weight portion add 3 times of water gaging distillating extracting oils; With inclusion essential oil, medicinal liquid is put in addition with the beta cyclodextrin of 6 times of amounts of volatile oil weight, and the Radix Codonopsis of medicinal residues and above-mentioned weight portion, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Fructus Aurantii Immaturus (parched), Semen Arecae Prepareta, Radix Lamiophlomidis Rotatae and Radix Glycyrrhizae Preparata seven flavor medicine add 8 times decocting and boil 2 times; Each 3 hours; Collecting decoction and above-mentioned medicinal liquid, through 250 order centrifugal filtrations, be condensed into temperature when being 65 ℃ relative density be 1.35 clear paste; Mix and vacuum drying with the Cortex Magnoliae Officinalis clear paste, be ground into extract powder; Get extract powder, volatile oil clathrate compound and 0.1 kilogram of lactose and 0.0001 kilogram of Aspartane mix homogeneously, process granule, packing is processed behind the sterilizing.
Embodiment 2
A kind of medicine of treating chronic superficial gastritis is that the medicine with following weight is a crude drug:
3 kilograms of Radix Codonopsis, 3 kilograms of the Rhizoma Atractylodis Macrocephalaes, 3 kilograms of Pericarpium Citri Reticulataes, 2 kilograms of the Rhizoma Pinelliaes, 6 kilograms of Rhizoma Alpiniae Officinarums, 6 kilograms of Rhizoma Cyperis, 6 kilograms in Rhizoma Zingiberis Recens, 3 kilograms of Fructus Aurantii Immaturuss, 3 kilograms of Cortex Magnoliae Officinalis, 3 kilograms of Semen Arecae Preparetas, 3 kilograms of Radix Lamiophlomidis Rotataes, 2 kilograms of Radix Glycyrrhizae Preparatas.
Concrete method for preparing is:
Get the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Rhizoma Cyperi and the Fructus Aurantii Immaturus of above-mentioned weight earlier, according to conventional method the Rhizoma Atractylodis Macrocephalae is processed Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae is processed Rhizoma Pinelliae, and Rhizoma Cyperi is processed Rhizoma Cyperi (processed with vinegar), and Fructus Aurantii Immaturus is processed Fructus Aurantii Immaturus (parched); It is 70% alcohol reflux 3 times that the Cortex Magnoliae Officinalis of getting above-mentioned weight portion again adds 8 times of amount mass fractions, each 2 hours, extracting solution reclaim ethanol to do not have alcohol distinguish the flavor of the Cortex Magnoliae Officinalis clear paste; Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi (processed with vinegar), the Rhizoma Zingiberis Recens four Chinese medicine of getting above-mentioned weight portion add 4 times of water gaging distillating extracting oils; With inclusion essential oil, medicinal liquid is put in addition with the beta cyclodextrin of 8 times of amounts of volatile oil weight, and the Radix Codonopsis of medicinal residues and above-mentioned weight portion, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Fructus Aurantii Immaturus (parched), Semen Arecae Prepareta, Radix Lamiophlomidis Rotatae and Radix Glycyrrhizae Preparata seven flavor medicine add 10 times decocting and boil 3 times; Each 2 hours; Collecting decoction and above-mentioned medicinal liquid, through 300 order centrifugal filtrations, be condensed into temperature when being 65 ℃ relative density be 1.37 clear paste; Mix and vacuum drying with the Cortex Magnoliae Officinalis clear paste, be ground into extract powder; Get extract powder, volatile oil clathrate compound and 0.3 kilogram of lactose and 0.00015 kilogram of Aspartane mix homogeneously, process granule, packing is processed behind the sterilizing.
Embodiment 3
A kind of medicine of treating chronic superficial gastritis is that the medicine with following weight is a crude drug:
5 kilograms of Radix Codonopsis, 5 kilograms of the Rhizoma Atractylodis Macrocephalaes, 5 kilograms of Pericarpium Citri Reticulataes, 3 kilograms of the Rhizoma Pinelliaes, 9 kilograms of Rhizoma Alpiniae Officinarums, 9 kilograms of Rhizoma Cyperis, 9 kilograms in Rhizoma Zingiberis Recens, 5 kilograms of Fructus Aurantii Immaturuss, 5 kilograms of Cortex Magnoliae Officinalis, 5 kilograms of Semen Arecae Preparetas, 5 kilograms of Radix Lamiophlomidis Rotataes, 3 kilograms of Radix Glycyrrhizae Preparatas.
Concrete method for preparing is:
Get the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Rhizoma Cyperi and the Fructus Aurantii Immaturus of above-mentioned weight earlier, according to conventional method the Rhizoma Atractylodis Macrocephalae is processed Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae is processed Rhizoma Pinelliae, and Rhizoma Cyperi is processed Rhizoma Cyperi (processed with vinegar), and Fructus Aurantii Immaturus is processed Fructus Aurantii Immaturus (parched); It is 80% alcohol reflux 2 times that the Cortex Magnoliae Officinalis of getting above-mentioned weight portion again adds 10 times of amount mass fractions, each 2.5 hours, extracting solution reclaim ethanol to do not have alcohol distinguish the flavor of the Cortex Magnoliae Officinalis clear paste; Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi (processed with vinegar), the Rhizoma Zingiberis Recens four Chinese medicine of getting above-mentioned weight portion add 5 times of water gaging distillating extracting oils; With inclusion essential oil, medicinal liquid is put in addition with the beta cyclodextrin of 10 times of amounts of volatile oil weight, and the Radix Codonopsis of medicinal residues and above-mentioned weight portion, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Fructus Aurantii Immaturus (parched), Semen Arecae Prepareta, Radix Lamiophlomidis Rotatae and Radix Glycyrrhizae Preparata seven flavor medicine add 12 times decocting and boil 2 times; Each 2.5 hours; Collecting decoction and above-mentioned medicinal liquid, through 350 order centrifugal filtrations, be condensed into temperature when being 65 ℃ relative density be 1.38 clear paste; Mix and vacuum drying with the Cortex Magnoliae Officinalis clear paste, be ground into extract powder; Get extract powder, volatile oil clathrate compound and 0.5 kilogram of lactose and 0.0002 kilogram of Aspartane mix homogeneously, process granule, packing is processed behind the sterilizing.
Claims (2)
1. medicine of treating chronic superficial gastritis is characterized in that with following parts of medicines by weight be crude drug:
1～5 part of Radix Codonopsis, 1～5 part of the Rhizoma Atractylodis Macrocephalae, 1～5 part of Pericarpium Citri Reticulatae, 1～3 part of the Rhizoma Pinelliae, 3～9 parts of Rhizoma Alpiniae Officinarums, 3～9 parts of Rhizoma Cyperis, 3～9 parts in Rhizoma Zingiberis Recens, 1～5 part of Fructus Aurantii Immaturus, 1～5 part of Cortex Magnoliae Officinalis, 1～5 part of Semen Arecae Prepareta, 1～5 part of Radix Lamiophlomidis Rotatae, 1～3 part of Radix Glycyrrhizae Preparata.
2. the method for preparing of the medicine of the described treatment chronic superficial gastritis of claim 1; It is characterized in that: get the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Rhizoma Cyperi and the Fructus Aurantii Immaturus of above-mentioned weight portion earlier, according to conventional method the Rhizoma Atractylodis Macrocephalae is processed Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae is processed Rhizoma Pinelliae; Rhizoma Cyperi is processed Rhizoma Cyperi (processed with vinegar), and Fructus Aurantii Immaturus is processed Fructus Aurantii Immaturus (parched); It is 60～80% alcohol reflux 2～3 times that the Cortex Magnoliae Officinalis of getting above-mentioned weight portion again adds 6～10 times of amount mass fractions, each 2～3 hours, extracting solution reclaim ethanol to do not have alcohol distinguish the flavor of the Cortex Magnoliae Officinalis clear paste; Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi (processed with vinegar), the Rhizoma Zingiberis Recens four Chinese medicine of getting above-mentioned weight portion add 3～5 times of water gaging distillating extracting oils; With inclusion essential oil, medicinal liquid is put in addition with the beta cyclodextrin of 6～10 times of amounts of volatile oil weight, and the Radix Codonopsis of medicinal residues and above-mentioned weight portion, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Fructus Aurantii Immaturus (parched), Semen Arecae Prepareta, Radix Lamiophlomidis Rotatae and Radix Glycyrrhizae Preparata seven flavor medicine add 8～12 times decocting and boil 2～3 times; Each 2～3 hours; Collecting decoction and above-mentioned medicinal liquid, through 250～350 order centrifugal filtrations, be condensed into temperature when being 65 ℃ relative density be 1.35～1.38 clear paste; Mix and vacuum drying with the Cortex Magnoliae Officinalis clear paste, be ground into extract powder; Get extract powder, volatile oil clathrate compound and 0.1～0.5 part of lactose and 0.0001～0.0002 part of Aspartane mix homogeneously, process granule, packing is processed behind the sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110294586A CN102327593A (en) | 2011-10-08 | 2011-10-08 | Medicament for treating chronic superficial gastritis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110294586A CN102327593A (en) | 2011-10-08 | 2011-10-08 | Medicament for treating chronic superficial gastritis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102327593A true CN102327593A (en) | 2012-01-25 |
Family
ID=45479723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110294586A Pending CN102327593A (en) | 2011-10-08 | 2011-10-08 | Medicament for treating chronic superficial gastritis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102327593A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106165885A (en) * | 2016-04-17 | 2016-11-30 | 马鞍山市志诚科技有限公司 | A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947304A (en) * | 2010-08-02 | 2011-01-19 | 李晓明 | Traditional Chinese medicinal composition for treating cold gastroenteropathy |
-
2011
- 2011-10-08 CN CN201110294586A patent/CN102327593A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947304A (en) * | 2010-08-02 | 2011-01-19 | 李晓明 | Traditional Chinese medicinal composition for treating cold gastroenteropathy |
Non-Patent Citations (5)
| Title |
|---|
| > 20081231 王雪梅 中西医结合治疗慢性胃炎68例 第64页 1 , 第19期 * |
| > 20110731 苏敏等 辨证治疗慢性浅表性胃炎80例疗效观察 第29-30页 1 第4卷, 第7B期 * |
| 李玉峰等: "慢性浅表性胃炎中医征候特征及辨证用药规律", <<中华中医药学会第二十二届全国脾胃病学术交流会暨2010年脾胃病诊疗新进展学习班论文汇编>>, 31 December 2010 (2010-12-31), pages 240 - 248 * |
| 王雪梅: "中西医结合治疗慢性胃炎68例", <<中外医疗>>, no. 19, 31 December 2008 (2008-12-31), pages 64 * |
| 苏敏等: "辨证治疗慢性浅表性胃炎80例疗效观察", <<临床合理用药>>, vol. 4, no. 7, 31 July 2011 (2011-07-31), pages 29 - 30 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106165885A (en) * | 2016-04-17 | 2016-11-30 | 马鞍山市志诚科技有限公司 | A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100518807C (en) | A Medicine for treatment of ascites due to cirrhosis | |
| CN100542596C (en) | A kind of medicine for the treatment of chronic gastritis, peptic ulcer | |
| CN101961401B (en) | Compound Chinese medicinal composition having effects of reducing weight, reducing fat, tonifying spleen and beautifying | |
| CN105727145A (en) | Traditional Chinese medicine drug for treating spleen deficiency phlegm-dampness syndrome type hyperlipidaemia | |
| CN102987507B (en) | Drink for patients with diabetes mellitus or constipation and preparation method thereof | |
| CN102698100B (en) | Oral solution for treating diabetes mellitus | |
| CN102274479B (en) | Traditional Chinese medicine composition for treating functional dyspepsia | |
| CN101120975A (en) | New use of traditional Chinese medicines Chinese yam, trichosanthin, and cortex lycii for heat-clearing blood-cooling and treating diabetes | |
| CN101167846A (en) | Capsule with blood sugar reducing function and preparation method thereof | |
| CN100509025C (en) | A medicine for treating diabetes | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN105055967B (en) | A kind of complex health care product and preparation method with auxiliary hyperglycemic function | |
| CN104258359A (en) | Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof | |
| CN105267818B (en) | A kind of Chinese medicine composition and preparation method thereof for treating epigastric pain | |
| CN103800689A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN102327593A (en) | Medicament for treating chronic superficial gastritis and preparation method thereof | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN106668616A (en) | Compound Dendrobium officinale Kimura et Migo oral solution with stomach-nourishing function | |
| CN101700390A (en) | Oral traditional Chinese medicine composition for treating fatty liver | |
| CN105169215A (en) | Traditional Chinese medicine composition for treating alcoholic fatty liver | |
| CN105250954A (en) | Traditional Chinese medicine for treating irritable bowel syndrome and preparation method of traditional Chinese medicine | |
| CN101721518A (en) | Traditional Chinese medicine for treating senile constipation | |
| CN104491316B (en) | A kind of Chinese medicine preparation for the treatment of deficiency of QI in middle-JIAO type hyperplasia of prostate | |
| CN104644956A (en) | Traditional Chinese medicine composition for treating cold congealing and blood stasis type dysmenorrheal and preparation method thereof | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120125 |