CN105169215A - Traditional Chinese medicine composition for treating alcoholic fatty liver - Google Patents
Traditional Chinese medicine composition for treating alcoholic fatty liver Download PDFInfo
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- CN105169215A CN105169215A CN201510412267.6A CN201510412267A CN105169215A CN 105169215 A CN105169215 A CN 105169215A CN 201510412267 A CN201510412267 A CN 201510412267A CN 105169215 A CN105169215 A CN 105169215A
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Abstract
The present invention relates to a traditional Chinese medicine composition for treating alcoholic fatty, wherein the traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 6-10 parts of radix bupleuri, 3-5 parts of folium artemisiae argyi, 5-8 parts of pericarpium citri reticulatae viride, 5-8 parts of cynara scolymus l, 6-10 parts of curcuma longa l, 3-5 parts of cynanchum otophyllum, and 3-5 parts of licorice root. According to the present invention, the traditional Chinese medicine composition has effects of liver soothing, cholaneresis, liver nourishing, qi regulating, qi and blood warming and smoothing, and liver and spleen conditioning; and clinical practice results show that the traditional Chinese medicine composition provides unique treatment effect on alcoholic fatty liver.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of alcoholic fatty liver.
Background technology
Alcoholic fatty liver alcoholic liver is the abbreviation of alcoholic liver disease, and according to estimates, about there are 1,500 ten thousand ~ 2,000 ten thousand people's excessive drinkings in the whole world, has 10% ~ 20% (1,500,000 ~ 4,000,000) to have alcoholic liver disease in various degree in these people.Alcoholic liver disease in early days can without any symptom, but now liver interior tissue there occurs pathological change.Alcoholic liver disease mainly can be divided three classes, i.e. alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis.These three kinds of forms separately or can mix existence.
The many factors affecting alcoholic liver injury progress or increase the weight of, studies the risk factor had been found that both at home and abroad at present and mainly comprises: drinking amount, Time of drink, alcoholic beverage kind, drinking type, sex, race, obesity, hepatites virus infections, inherited genetic factors, nutriture etc.According to Epidemiological study data, the hepatic injury that ethanol causes has threshold effect, namely reaches certain drinking amount or Time of drink, will greatly increase hepatic injury risk.But, because individual variation is comparatively large, also there is research display to drink very not clear and definite with the dose-effect relationship of hepatic injury.Alcoholic beverage kind is more, and the infringement that different alcoholic beverage causes liver is also variant.Drinking type is also a risk factor of alcoholic liver injury, drinks on an empty stomach more easily to cause hepatic injury compared with the drinking type of having meal.The liver toxicity that women mediates ethanol is more responsive, and compared with male, the more low dose of and shorter time limit of drinking just may occur heavier alcoholic liver disease.Drink the alcoholic beverage of isodose, in men and women's blood, alcohol water shows variant dawn.Race, heredity and individual variation are also the important risk factor of alcoholic liver disease.The gene frequency of the alcoholic liver disease tumor susceptibility gene ethanol dehydrogenase (ADH) 2 of Chinese Han Population, ADH3 and aldehyde dehydrogenase (ALDH) 2 and genotype distribution are different from western countries, may be that China is addicted to drink the sickness rate of crowd and alcoholic liver disease lower than one of Hesperian reason.Can there is alcoholic liver disease in not all alcohol user, just occur in sub-fraction crowd, shows also to there is individual variation between the colony of areal.The rising of alcoholic liver disease case fatality rate is relevant to underfed degree.Lacking or the decline of Vitamin E levels of vitamin A, also liver injury may be increased the weight of.The diet being rich in polyunsaturated fatty acid can impel the progress of alcoholic liver disease, and satisfied fatty acid plays a protective role to alcoholic liver disease.Obesity or the overweight risk increasing alcoholic liver disease progression of weight.Hepatites virus infections and ethanol play synergism to liver injury, drink in hepatites virus infections basis, or on alcoholic liver disease basis concurrent HBV or HCV infection, all can accelerate generation and the development of hepatic disease.
The treatment of current alcoholic fatty liver, treatment by Chinese herbs is in the great majority because the little convenience of side effect is easily got, but mostly adopt the medical material function of gallbladder promoting heat clearing away of bitter cold, detoxifying, removing dampness, these prescriptions are for the people of most of deficiency and coldness body constitution, although medicine makes liver improve, easy insufficiency of the spleen cold syndrome of the stomach etc. damage yang-energy, long-term taking can make body constitution worse and worse, affects healthy.
Summary of the invention
The object of the invention is to overcome prior art not enough and a kind of Chinese medicine composition for the treatment of alcoholic fatty liver is provided, depressed liver-energy dispersing and QI regulating, warm venting QI-blood, lipotropicly nurse one's health health simultaneously, protect the liver strong body.
The technical scheme that the present invention takes is:
Treat a Chinese medicine composition for alcoholic fatty liver, be made up of the crude drug of following weight part ratio:
Radix Bupleuri 6-10 part, Folium Artemisiae Argyi 3-5 part, Pericarpium Citri Reticulatae Viride 5-8 part, Cynara scolymus L (Cyhara cardunculus.) 5-8 part, Rhizoma Curcumae Longae 6-10 part, Radix Paeoniae Alba 3-5 part and Radix Glycyrrhizae 3-5 part.
The Chinese medicine composition of described treatment alcoholic fatty liver, is preferably made up of the crude drug of following weight part ratio: Radix Bupleuri 6 parts, Folium Artemisiae Argyi 3 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.) 5 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Paeoniae Alba 5 parts and 3 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of described treatment alcoholic fatty liver, decocts with water twice by each crude drug, and first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filtration, merging filtrate.
Radix Bupleuri bitter in the mouth of the present invention, pungent, cold nature.Return liver, gallbladder meridian.Effect is brought down a fever for inducing sweat, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise and can fall.Pericarpium Citri Reticulatae Viride: bitter, pungent, warm.Return liver, gallbladder, stomach warp, soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.Cynara scolymus L (Cyhara cardunculus.): sweet, flat.Depressed liver-energy dispersing and function of gallbladder promoting, rushes down clearly damp and hot.Clinical in jaundice, two side of body distending pain, the diseases such as damp-heat dysentery.Rhizoma Curcumae Longae is pungent, bitter, temperature.Return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.The acid of Radix Paeoniae Alba bitter in the mouth, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Radix Glycyrrhizae property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.All medicine compatibilities, have depressed liver-energy dispersing and function of gallbladder promoting, easing the affected liver is regulated the flow of vital energy, warm venting QI-blood, the merit of harmonizing the liver and spleen.Find, to alcoholic fatty liver, there is unique curative effect through clinical practice.
Detailed description of the invention
Further illustrate below in conjunction with embodiment.
Embodiment 1
The Chinese medicine composition for the treatment of alcoholic fatty liver: Radix Bupleuri 6 parts, Folium Artemisiae Argyi 3 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.) 5 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Paeoniae Alba 5 parts and 3 parts, Radix Glycyrrhizae.Each crude drug is decocted with water twice, and first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filtration, merging filtrate.
Embodiment 2
The Chinese medicine composition for the treatment of alcoholic fatty liver: Radix Bupleuri 8 parts, Folium Artemisiae Argyi 4 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.) 6 parts, 7 parts, Rhizoma Curcumae Longae, the Radix Paeoniae Alba 4 parts and 4 parts, Radix Glycyrrhizae.
Each crude drug is decocted with water twice, and first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filtration, merging filtrate.
Embodiment 3
Radix Bupleuri 10 parts, Folium Artemisiae Argyi 5 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.) 8 parts, 10 parts, Rhizoma Curcumae Longae, the Radix Paeoniae Alba 3 parts and 5 parts, Radix Glycyrrhizae.Each crude drug is decocted with water twice, and first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filtration, merging filtrate.
Clinical trial
1, case is chosen
In choose 52 routine patients, the age 30-50 year, women 10 example, male 42 example, has following symptom in various degree: dizzy weak, dry mouth with bitter taste, stomatoglossitis, tongue fur stick greasy, belch is felt sick, rise tripe dyspepsia, uncomfortable in chest, abdominal distention, liver pain.
2, diagnostic criteria
The alcoholic fatty liver diagnosis of formulating according to Chinese Medical Association's hepatopathy association fatty liver and alcoholic liver disease group
Standard:
1) drink and be greater than 40g/ days;
2) wine storage time >=5 years;
3) more than 2 are had to raise in alanine aminotransferase, aspartate aminotransferase, alkali phosphatase, glutamic acid transferring enzyme;
4) check that confirmation has fatty liver to exist through B ultrasonic or CT etc.
3, Therapeutic Method
Choose Radix Bupleuri 6g, Folium Artemisiae Argyi 3g, Pericarpium Citri Reticulatae Viride 5g, Cynara scolymus L (Cyhara cardunculus.) 5g, Rhizoma Curcumae Longae 6g, Radix Paeoniae Alba 5g and Radix Glycyrrhizae 3g.Each crude drug is decocted with water twice, and first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filtration, merging filtrate.Every day 1 dose, every day 2 times 20 days was 1 course for the treatment of.
4, therapeutic outcome:
4.1 carry out efficacy determination according to " new Chinese medicine guideline of clinical investigations ":
Cure: B ultrasonic display fatty liver disappears, and rate and blood-lipid decreased is to normal range, and liver function is normal, transference cure;
Effective: B ultrasonic display fatty liver degree alleviates, ALT decline > 20%, rate and blood-lipid decreased > 10%, and symptom takes a turn for the better;
Invalid: B ultrasonic display fatty liver degree is unchanged, and rate and blood-lipid decreased < 10%, ALT decline < 20%, symptom is without alleviating.
4.2 results: in 52 routine patients, cure 29 examples (55.8%), effective 18 examples (34.6%), and invalid 5 examples (9.6%), total effective rate is 90.4%.
5, model case
Patient A man, patient drinks 25 years, about 150-200g/d; B ultrasonic of having a medical check-up prompting fatty liver 5 years.AD: alcoholic fatty liver hepatitis, hypertension 1 grade, hypertriglyceridemia, impaired glucose tolerance.Traditional Chinese medical science aspect considers to there is stagnation of liver-QI with deficiency of the spleen.After taking 1 course for the treatment of of medicine of the present invention, all diseases alleviate, and continue to take 3 courses for the treatment of, and check liver function, blood fat are all normal, and CT shows: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.
Patient B female, history of drinking history more than 5 years, there is RHC and flank pain in patient, is moderate persistent, compression pain.Pain that patient is "dead", jaundice, yellowish urine, tired, inappetence, axersis, xerophthalmia or heating.The virusology of hepatitis A, B, C detects and is feminine gender.Patient raises without bilirubin, but alanine aminotransferase and total cholesterol level slightly raise, and is moderate alcoholic fatty liver, weakness of the spleen and stomach.After taking 1 half course for the treatment of of medicine of the present invention, all diseases alleviate, and continue to take 3 courses for the treatment of, and check liver function, cholesterol are all normal, and liver and gall spleen pancreas shows no obvious abnormalities.
Claims (3)
1. treat a Chinese medicine composition for alcoholic fatty liver, it is characterized in that, be made up of the crude drug of following weight part ratio:
Radix Bupleuri 6-10 part, Folium Artemisiae Argyi 3-5 part, Pericarpium Citri Reticulatae Viride 5-8 part, Cynara scolymus L (Cyhara cardunculus.) 5-8 part, Rhizoma Curcumae Longae 6-10 part, Radix Paeoniae Alba 3-5 part and Radix Glycyrrhizae 3-5 part.
2. the Chinese medicine composition for the treatment of alcoholic fatty liver according to claim 1, is characterized in that, is made up of the crude drug of following weight part ratio: Radix Bupleuri 6 parts, Folium Artemisiae Argyi 3 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.) 5 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Paeoniae Alba 5 parts and 3 parts, Radix Glycyrrhizae.
3. the preparation method of the Chinese medicine composition of the treatment alcoholic fatty liver described in claim 1 or 2, is characterized in that, each crude drug is decocted with water twice, first time adds the soak by water 2 hours of crude drug quality 10 times, and second time adds the water of crude drug quality 8 times, decocts 1 hour, filter, merging filtrate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107712224A (en) * | 2017-12-04 | 2018-02-23 | 爱可道生物科技有限公司 | A kind of globe artichoke shield courage tea and preparation method |
| CN111658746A (en) * | 2020-07-16 | 2020-09-15 | 中山大学附属第一医院 | Traditional Chinese medicine composition for treating alcoholic fatty liver and preparation method thereof |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103479691A (en) * | 2013-09-30 | 2014-01-01 | 四川德培源中药科技开发有限公司 | Lipid-decreasing liver protection traditional Chinese medicine composition |
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| CN107712224A (en) * | 2017-12-04 | 2018-02-23 | 爱可道生物科技有限公司 | A kind of globe artichoke shield courage tea and preparation method |
| CN111658746A (en) * | 2020-07-16 | 2020-09-15 | 中山大学附属第一医院 | Traditional Chinese medicine composition for treating alcoholic fatty liver and preparation method thereof |
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Inventor after: Dan Qiuli Inventor after: Li Yanhua Inventor after: Chen Muyang Inventor after: Gu Jinsong Inventor after: Han Tian Inventor after: Hao Weiwei Inventor before: Dan Qiuli Inventor before: Bao Jie Inventor before: Zhao Fang Inventor before: Fang Chengcheng Inventor before: Ma Yan Inventor before: Zhang Xiaohui |
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Application publication date: 20151223 |
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