CN103479691A - Lipid-decreasing liver protection traditional Chinese medicine composition - Google Patents
Lipid-decreasing liver protection traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a lipid-decreasing liver protection traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicine compositions. The lipid-decreasing liver protection traditional Chinese medicine composition is an agent, a health care product or food and is prepared by raw materials of stems and leaves of radix bupleuri, white peony roots, liquorice, hawthorn, salvia miltiorrhiza and rhizoma alismatis. Clinical verifications show that the traditional Chinese medicine composition can protect the liver, soften blood vessels and decrease lipid through long-time use; and the traditional Chinese medicine composition has remarkable prevention and treatment effects on symptoms and diseases such as fatty liver, hyperlipidemia, angiosclerosis and the like which are caused by glucose and lipid metabolism disorder of middle-aged and aged people.
Description
Technical field
The invention discloses a kind of fat-reducing liver-protecting Chinese medicine composition, belong to food, health product or the field of Chinese medicines.
Background technology
Modern way of life changes the physical and mental health that the metabolic disease caused has had a strong impact on people, causes great burden on society, and increasing people suffers from the glycolipid metabolism dysfunction cases, and middle-aged and elderly people is particularly serious.Modern medicine thinks that the glycolipid metabolism disorder is the main pathological characters of metabolism syndrome, it is also the key element of multiple risk factors in metabolism syndrome, it is pathologic basis and the main hazard factor of apoplexy, coronary heart disease, myocardial infarction and other multiple chronic disease, modal have hyperlipidemia, diabetes, fatty liver, hypertension, impaired glucose tolerance (IGI), a fasting glucose impairment (IFG) etc., for its prevention and treatment, medical circle not yet has the significant medicine of therapeutical effect.
The traditional Chinese medical science thinks, the categories such as the disorderly relevant disease of glycolipid metabolism belongs to that the traditional Chinese medical science is quenched one's thirst, the thoracic obstruction, cardiopalmus, headache, dizzy, phlegm-damp, and main pathogenesis is the liver failing to maintain the normal flow of QI, causes visceral dysfunction, body fluid loses the syndrome caused in defeatedization.Liver controlling conveyance and dispersion, catharsis is " dredging ", " happy ", and the meaning of " bar reaches ", that is to say, under the normal physiological state, irritability has dredging, and the characteristic that bar reaches, this function is mainly reflected in the dredging of liver to mechanism of qi, and " mechanism of qi " i.e. be the ascending, descending, exiting and entering motion of gas.The activities such as the internal organs of body, meridians, organ, rely the ascending, descending, exiting and entering motion in gas entirely.And the physiological characteristics of liver is main liter, initiatively, so, this dredging for mechanism of qi, fluent, rise the important factor beyond doubt of sending out.Therefore, whether the catharsis function of liver is normal, for the balance coordination between the ascending, descending, exiting and entering of gas, plays a part adjusting.Blood-fat and blood sugar is just as nutrient blood body fluid, is the cereal nutrient that water paddyization is given birth to, and the catharsis function of liver is normal, QI movement being in harmonious way, and lifting is suitable, QI and blood and tune, the meridians tonneau, the internal organs organ dysfunction is normal.Essence of water and grain is concentrated blood vessels on, and warm skin moistens and supports the internal organs bones of the body collectively.Surfeit delicious food pure wine savoury, sitting lying on bed for a long time damage temper, the loose essence of spleen, vital essence can not on be attributed to lung and towards hundred arteries and veins, water paddy elite is detained and is not changed, soil plug wood is strongly fragrant, strongly fragrant and heat-transformation, consumption impairment of QI Tianjin, clear QI failing to ascend, turbid YIN failing to descend, accumulatively wet raise phlegm, stay and form the stasis of blood, expectorant is turbid, blood stasis checks the meridians internal organs and causes blood pressure and blood lipoid to raise, and this is the Basic disease cause pathogenesis of the disorderly relevant disease of glycolipid metabolism.Therefore, soothing the liver nourishing blood to suppress the hyperactive liver, the promoting flow of QI and blood blood stasis dispelling, change base therapy and Precautionary Principle that turbid blood fat reducing eliminating dampness by diuresis is the glycolipid metabolism disorder.
The Guo Jiao of Traditional Chinese Medicine University Of Guangzhou etc. also think that the crucial pathogenesis of metabolic disease is " liver is lost pivot and uses ", theory and " hinge hepatic metabolism regulating system " concept of " take liver as pivot; adjust esterified turbid " have been proposed, think that liver is core and the hinge of the hyperlipemia metabolic disease morbidity internal organs (liver spleen kidney) that are representative, for the Chinese medicine prevention of metabolic disease provides thinking.
Therefore, soothing the liver nourishing blood to suppress the hyperactive liver, the promoting flow of QI and blood blood stasis dispelling, changing turbid blood fat reducing is the new direction for the treatment of glycolipid metabolism disorder.Though Western medicine is instant effect aspect treatment glycolipid metabolism dysfunction cases, cures the symptoms, not the disease, toxic and side effects is large, to the patient, increases new burden, as: Simvastatin Treatment hyperlipemia lipid-lowering effect is fast, but liver function is had to certain damaging action; Chinese herbal medicine specimen is double to be controlled, and toxic and side effects is little, aspect treatment glycolipid metabolism dysfunction cases, more is being applicable to mid-aged population.So, provide a kind of extensively be applicable to mid-aged population and effectively the Chinese medicine preparation of fat-reducing liver-protecting be one and be worth the problem of studying.
Radix Bupleuri is large conventional Chinese medicine, and pharmacopeia regulation Radix Bupleuri only has root just can be used as medicine, the effects such as so be used as medicine with the root of Radix Bupleuri at present generally, that its root has is analgesic, analgesia, calmness, antiinflammatory.Generally believe that the Radix Bupleuri all herbal medicine can reduce the quality of medicine, so gather in the crops and often the Radix Bupleuri stem and leaf is abandoned as garbage in the early spring.In recent years, carried out gradually the pharmacological research to the Radix Bupleuri stem and leaf both at home and abroad, found that the Radix Bupleuri stem and leaf has the effects such as enhancing immunity, antiviral, antiinflammatory, analgesia and antioxidation.Therefore the Radix Bupleuri stem and leaf goes out of use, and has not only caused the huge wasting of resources, also to the peasant, causes economic loss, is unfavorable for very much the development of Radix Bupleuri industry.
Application for the Radix Bupleuri stem and leaf in concrete medicine, also nobody relates to.And also have no at present both at home and abroad and take bibliographical information and the patent application that the Radix Bupleuri stem and leaf makes medicine, health product or food as primary raw material.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, change the Radix Bupleuri industry situation that utilization is not good to the Radix Bupleuri stem and leaf now, make up the blank of Radix Bupleuri stem and leaf aspect medicinal application simultaneously, provide the Radix Bupleuri stem and leaf to there is the application in the Chinese medicine composition of fat-reducing liver-protecting effect in preparation, further provide a kind of and take the Radix Bupleuri stem and leaf as one of main component, be widely used in the hepatoprotective that mid-aged population has positive and reliable effect, vessel softening, change the Chinese medicine composition of turbid blood fat reducing.
In order to realize the foregoing invention purpose, the technical solution used in the present invention is as follows:
A kind of fat-reducing liver-protecting Chinese medicine composition, it is to take medicament, health product or the food that the Radix Bupleuri stem and leaf makes as primary raw material.
Further, the Radix Bupleuri stem and leaf can be used with one or more drug matchings of regulating glycolipid metabolism, as: the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, the Radix Astragali, Ganoderma, Herba Taraxaci, Radix Puerariae, Rhizoma Curcumae Longae, Rhizoma Atractylodis, Folium Nelumbinis, Fructus Chaenomelis, Herba Apocyni veneti, Radix Achyranthis Bidentatae, Fructus Gardeniae, Fructus Lycii, Flos Chrysanthemi, Radix Rehmanniae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Os Draconis, Concha Ostreae, Concha Margaritifera, Carapax et Plastrum Testudinis, Radix Scutellariae, Fructus Liquidambaris, Concha Haliotidis, Spica Prunellae etc.
Further, the tender point that Radix Bupleuri stem and leaf of the present invention is Radix Bupleuri.
Fat-reducing liver-protecting Chinese medicine composition provided by the invention, raw material also comprises Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis.
Best, fat-reducing liver-protecting Chinese medicine composition of the present invention, raw material also comprises the Radix Paeoniae Alba, Radix Glycyrrhizae.It is monarch drug altogether that this Chinese medicine composition be take Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, and take Fructus Crataegi, Radix Salviae Miltiorrhizae is ministerial drug altogether, take Rhizoma Alismatis as adjuvant drug, with Radix Glycyrrhizae for making medicine.Folium Bupleuri 5 Radix Paeoniae Albas, dispersing the stagnated live-QI to relieve the stagnation of QI, nourishing blood to suppress the hyperactive liver, Fructus Crataegi circulation of qi promoting dissipating blood stasis, change turbid blood fat reducing, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, the relieving restlessness that clears away heart-fire, the Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expel the heat-evil, and changes turbid blood fat reducing, Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.All medicines share, and have significant fat-reducing liver-protecting effect.
Further, in above-mentioned fat-reducing liver-protecting Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 10-50 part, Radix Paeoniae Alba 8-30 part, Radix Glycyrrhizae 2-15 part, Fructus Crataegi 20-60 part, Radix Salviae Miltiorrhizae 20-60 part, Rhizoma Alismatis 2-12 part.
Preferably, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri stem and leaf 12-40 part, Radix Paeoniae Alba 9-20 part, Radix Glycyrrhizae 3-10 part, Fructus Crataegi 25-45 part, Radix Salviae Miltiorrhizae 25-45 part, Rhizoma Alismatis 5-10 part.
Preferred, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri stem and leaf 15-30 part, Radix Paeoniae Alba 10-15 part, Radix Glycyrrhizae 4-8 part, Fructus Crataegi 27-35 part, Radix Salviae Miltiorrhizae 26-40 part, Rhizoma Alismatis 7-9 part.
Most preferably, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: 20 parts of Radix Bupleuri stem and leaf, 12 parts of the Radix Paeoniae Albas, 5 parts, Radix Glycyrrhizae, 30 parts of Fructus Crataegis, 30 parts of Radix Salviae Miltiorrhizaes, 8 parts of Rhizoma Alismatis.
The Radix Bupleuri stem and leaf has the application in the Chinese medicine composition of fat-reducing liver-protecting effect in preparation.
The medicament of fat-reducing liver-protecting Chinese medicine composition of the present invention, health product or food, can through extraction or other modes, process by the raw material that above-mentioned formula is formed, make pharmaceutically active substance, take this material as raw material, add medicine, health product or food acceptable carrier or adjuvant while needing, make according to routine techniques.Described active substance can obtain by extracting respectively raw material, also can obtain by common extraction raw material, also can obtain by other means, as: by pulverizing, squeeze, grind, sieve, the method such as extraction, water extraction, alcohol extraction, ester carry, chromatography obtains, these active substances can be the materials of extractum form, can be that dry extract can be also fluid extract, according to the difference of preparation, need to determine to make different concentration.
Fat-reducing liver-protecting Chinese medicine composition of the present invention, its pharmaceutically active substance makes through extracting processing, and processing can adopt any combination in said method.
A kind of preparation method of fat-reducing liver-protecting Chinese medicine composition of the present invention comprises the following steps:
(1) take in proportion Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis;
(2) raw material in step (1) is prepared into to extract or crude drug powder in the following manner:
A) be prepared into respectively extract or crude drug powder,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder,
C) whole mixed raw materials standby one-tenth extracts or crude drug powder;
(3) extract of gained raw material in step (2) or crude drug powder are mixed, make acceptable various pharmaceutical dosage form, health product or food.
Further, step in the preparation method of fat-reducing liver-protecting Chinese medicine composition of the present invention (2) comprising: get the Radix Bupleuri stem and leaf in step (1), and the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, mix, and extracts, and obtains extract.
Fat-reducing liver-protecting Chinese medicine composition of the present invention adds conventional adjuvant or carrier can make one or more products such as decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, syrup, buccal tablet, chewable tablet, electuary, pill, drop pill or injection according to common process to be used.For example, take in proportion the Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, pulverize above-mentioned raw materials, mix homogeneously, every part by a certain amount of health paper bag of use of making tea of packing into, and after sealing, packing, make medicinal tea; Perhaps take in proportion the Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract, adds adjuvant, and mix homogeneously is granulated, encapsulated, obtains capsule.
Compared with prior art, the invention has the beneficial effects as follows:
Fat-reducing liver-protecting Chinese medicine composition of the present invention, a kind of Chinese medicine composition that the Radix Bupleuri stem and leaf is one of constituent of take is provided, realized the comprehensive utilization of Radix Bupleuri, made up the Radix Bupleuri stem and leaf medicinal application aspect blank, compositions hepatoprotective of the present invention, vessel softening, lipid-lowering effect is remarkable, and side effect is little, to mid-aged population because of fatty liver due to the glycolipid metabolism disorder, hyperlipidemia, the symptom such as sclerosis of blood vessels and disease have significant preventive and therapeutic action.And through clinical observation, show, its total effective rate reaches 98.18%.
Fat-reducing liver-protecting Chinese medicine composition of the present invention both can be made health product, food, can make medicine again, had greatly expanded the scope of application.Medicine material of the present invention all easily obtains from the market, and preparation method is simple, has very strong application value.
The specific embodiment
Below in conjunction with test example and the specific embodiment, the present invention is described in further detail.But this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Following embodiment and experimental technique, if no special instructions, be conventional method; Described reagent and medicine, if no special instructions, all can obtain from commercial channels.
Embodiment 1 medicinal tea
Radix Bupleuri stem and leaf 10g, Radix Paeoniae Alba 8g, Radix Glycyrrhizae 5g, Fructus Crataegi 20g, Radix Salviae Miltiorrhizae 20g, Rhizoma Alismatis 8g, pulverize above-mentioned raw materials, mix homogeneously, every part of 5g health paper bag of use of making tea of packing into, after sealing, packing, make medicinal tea.
Embodiment 2 beverages
Radix Bupleuri stem and leaf 30g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 10g, Fructus Crataegi 40g, Radix Salviae Miltiorrhizae 40g, Rhizoma Alismatis 10g, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract.
Get above-mentioned dry extract, process routinely, comprise the steps such as allotment-homogenizing-degassed-pasteurize-fill-cooling, can obtain finished beverage.
Embodiment 3 capsules
Radix Bupleuri stem and leaf 40g, Radix Paeoniae Alba 20g, Radix Glycyrrhizae 15g, Fructus Crataegi 50g, Radix Salviae Miltiorrhizae 40g, Rhizoma Alismatis 12g, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract.
Get above-mentioned dry extract, according to common process, add Pulvis Talci, starch, mix homogeneously, granulate, encapsulated, obtains capsule.
Embodiment 4 tablets
Radix Bupleuri stem and leaf 50g, Radix Paeoniae Alba 20g, Radix Glycyrrhizae 15g, Fructus Crataegi 60g, Radix Salviae Miltiorrhizae 60g, Rhizoma Alismatis 12g, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract.
Get above-mentioned dry extract, according to common process, add calcium carbonate, starch, mix homogeneously, tabletting, obtain tablet.
Embodiment 5 oral liquids
Radix Bupleuri stem and leaf 25g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract.
Get above-mentioned dry extract, be dissolved in water according to common process, regulate pH value, add solubilizing agent, antiseptic, correctives, fill, make oral liquid.
Embodiment 6 granules
Radix Bupleuri stem and leaf 35g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, mix homogeneously, adopt the decocting cooking method to extract thick paste, and drying under reduced pressure, pulverize, and obtains dry extract.
Get above-mentioned dry extract, according to common process, add dextrin, cane sugar powder, mix, add appropriate 90% ethanol, granulation.
Embodiment 7 decoctions
Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, mix and put into container, add suitable quantity of water, decoct to the water boiling, after 5～10 minutes, add Radix Bupleuri stem and leaf 20g, again decoct 5～10 minutes, total decocting time is about 20～30 minutes, removes solid residue, can make decoction of the present invention.
Experimental example 1
1. case choice criteria
1.1 tcm syndrome differentiation and typing standard: the liver failing to maintain the normal flow of QI, visceral dysfunction, body fluid loses the qi stagnation and blood stasis type in defeatedization.Card is shown in dizziness headache, fullness and distention in the chest and hypochondrium or twinge, and palpitation and uneasiness, vertigo and tinnitus, or companion's excessive thirst polydipsia, the emotion irritability, or fat or become thin, purplish tongue, stringy and hesitant pulse.Lab testing TC, TG exceed normal value more than 10%, abnormal liver function, and liver ultrasound is shown in the fatty pathological changes.
1.2 inclusive criteria: according to the patient that the tcm diagnosis standard diagnostics is the thoracic obstruction, cardiopalmus, headache, dizzy, the qi depression to blood stasis symptom appears in the disease such as quench one's thirst.Hyperlipemia meets the hyperlipemia diagnostic criteria that State Administration of Traditional Chinese Medicine's " guideline of clinical investigations of new Chinese medicine treatment hyperlipemia " formulates, and the Diagnosis of Fatty liver standard meets Diagnosis of Fatty liver standard in " up-to-date domestic and international Disease Diagnosis Standard ".Complicated with Hypertension, diabetes, its complication state of an illness of patients with coronary heart disease should be in stable phase.The range of age is in 25-76 year; Adhere to according to plan therapist the course for the treatment of.
1.3 exclusion standard: do not meet the above-mentioned traditional Chinese medical science thoracic obstruction, cardiopalmus, headache, dizzy, the qi stagnation and blood stasis type symptom of the quenching one's thirst person of description, the age is less than 25 years old or is greater than 76 years old person; Modern medicine is not diagnosed as fatty liver, hyperlipemia, and Complicated with Hypertension, diabetes, its complication state of an illness of patients with coronary heart disease are not stablized the person.
1.4 rejecting standard: do not complete person's course for the treatment of; Because of the serious adverse reaction terminator.
2. clinical observation
In year June certain traditional Chinese medical science front three hospital in July, 2003 to 2011 consulting patients in out-patient department, choose the patient that 1355 examples meet above-mentioned inclusive criteria.Three groups of observation in random minute, treatment group 660 examples, age 25-75 year, mean age (45.6 ± 2.5) year, male patient 396 people, female patient 264 people, course of disease 2-30, average course of disease (16.2 ± 1.4) year; Wherein, Patients with Fatty Liver 325 examples, hyperlipemia 335 examples, complicated with hypertension 111 examples, complicated with diabetes patient 55 examples, concurrent patients with coronary heart disease 52 examples.
Matched group one 660 examples, age 26-76 year, year mean age (46.2 ± 2.1), male patient 389 people, female patient 271 people, course of disease 3-31, average course of disease (16.5 ± 1.7) year; Wherein, Patients with Fatty Liver 331 examples, hyperlipemia 329 examples, complicated with hypertension 108 examples, complicated with diabetes patient 57 examples, concurrent patients with coronary heart disease 51 examples.
Matched group 2 35 examples, year mean age (45.6 ± 2.5), male patient 20 people, female patient 15 people, course of disease 2-30, average course of disease (16.2 ± 1.4) year; Wherein, Patients with Fatty Liver 15 examples, hyperlipemia 5 examples, complicated with hypertension 11 examples, complicated with diabetes patient 5 examples, concurrent patients with coronary heart disease 12 examples.
Between three groups at aspects such as age, the course of disease, severity extent, extent of disease, symptoms without marked difference (P>0.05), there is comparability.
3. Therapeutic Method
Treatment group: select decoction of the present invention (according to embodiment 7 methods preparations) to take, 1 dose/day, each once, after taking January, is used medicinal tea instead and continues to take two months sooner or later, each 5g, the boiled water three guarantees that are taken after being infused in hot water or decoction every day.Other antihyperglycemic hepatoprotective agent of stopping using during treatment, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add respectively the corresponding chemical medicine.Advise patient's daily life rule, moderate exercise, do not stay up late, and non-smoking does not drink, and the greasy food of edible oil, do not eat the vegetable and the fruit that are rich in vitamin more.
Matched group one: Patients with Fatty Liver, take the polyene phosphatidylcholine capsule, each 2 (456mg), every day 3 times, take three months; Hyperlipemia, take the simvastatin sheet, every day 20mg, take once night every day, takes three months.Other antihyperglycemic hepatoprotective agent of stopping using during treatment, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add respectively the chemotherapeutic agent same with treatment group.Advise patient's daily life rule, moderate exercise, do not stay up late, and non-smoking does not drink, and the greasy food of edible oil, do not eat the vegetable and the fruit that are rich in vitamin more.
Matched group two: the decoction oral that uses the compositions lack the Radix Bupleuri stem and leaf to boil, 1 dose/day, each once, after taking one month, continues to use the medicinal tea of making without the compositions of Radix Bupleuri stem and leaf to make tea and takes two months sooner or later, each 5g, the boiled water three guarantees that are taken after being infused in hot water or decoction every day.Other antihyperglycemic hepatoprotective agent of stopping using during treatment, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add respectively corresponding chemotherapeutic agent.Advise patient's daily life rule, moderate exercise, do not stay up late, and non-smoking does not drink, and the greasy food of edible oil, do not eat the vegetable and the fruit that are rich in vitamin more.
4. efficacy assessment standard
Hyperlipemia is according to the curative effect determinate standard of State Administration of Traditional Chinese Medicine's " new Chinese medicine treatment hyperlipemia guideline of clinical investigations ".Clinical cure: clinical symptoms, sign disappear, and the every inspection of laboratory recovers normal; Produce effects: clinical symptoms, sign disappear substantially, and lipids detection reaches following any one person, i.e. TC index rate of descent >=20%, TG index rate of descent >=40% or HDL-C index >=0.26mmol/L; Effectively: lipids detection reaches following any one person, and simultaneously<20%, TG index rate of descent >=20% simultaneously<40% or HDL-C index >=0.104mmol/L while<0.26mmol/L for TC index rate of descent >=10%; Invalid: after treatment, symptom, sign and lipids detection are not improved.
Fatty liver is with reference to the criterion of " clinical disease diagnosis is according to curing the improvement standard ".Clinical cure: fatty liver disappears, and TC, TG, liver power recovery are normal; Produce effects: fatty liver is clearly better, and TC, TG, liver function are obviously improved; Effectively: fatty liver take a favorable turn, and TC, TG, liver function all are improved but are not remarkable; Invalid: fatty liver, blood fat, liver function are unchanged.
Total effective rate=(clinical cure+produce effects+effectively)/total number of cases * 100%.
5. statistical method
Enumeration data means with percentage rate (%), relatively adopts X2(X square between group) check, there is statistical significance P<0.05 for difference.Concrete numerical value and the results are shown in Table 1.
Table 1, treatment group and matched group Clinical efficacy comparison
Annotate: compare P<0.05 with matched group one, matched group two
6. result
As shown in Table 1, the treatment group total effective rate is 98.18%, total effective rate 71.42% higher than matched group one total effective rate 91.06% and matched group two, difference has statistical significance (P<0.05), uses as seen the effect of the present composition to be better than using the effect of Western medicine and the effect that use lacks the compositions of Radix Bupleuri stem and leaf.Fatty liver, hyperlipemia due to the disorder of experimental result explanation glycolipid metabolism, and Complicated with Hypertension, diabetes, coronary heart disease but the patient of complication stable disease is better with the Chinese medicine preparation conditioning effect of the present invention's formula, treat also more comprehensive.Polyene phosphatidyl choline for treating fatty liver liver protective effect is good, but lipid-lowering effect is general; Simvastatin Treatment hyperlipemia lipid-lowering effect is good, but liver function is had to certain damaging action; And the present composition considers for etiology and pathogenesis, reinforce insufficiency and reduce excessiveness, soothing the liver nourishing blood to suppress the hyperactive liver, the promoting flow of QI and blood blood stasis dispelling, change turbid blood fat reducing eliminating dampness by diuresis, and toxic and side effects is little, is applicable to very much the prevention of mid-aged population to above-mentioned disease, and the treatment of rear stable disease phase of morbidity.Also show that in Radix Bupleuri stem and leaf and the present composition, all the other components have obvious synergistic function, three groups obvious adverse reaction does not all occur simultaneously.
Claims (10)
1. a fat-reducing liver-protecting Chinese medicine composition, is characterized in that, it is to take medicament, health product or the food that the Radix Bupleuri stem and leaf makes as primary raw material.
2. fat-reducing liver-protecting Chinese medicine composition according to claim 1, is characterized in that, the raw material of this Chinese medicine composition also comprises Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis.
3. fat-reducing liver-protecting Chinese medicine composition according to claim 2, is characterized in that, the raw material of this Chinese medicine composition also comprises the Radix Paeoniae Alba, Radix Glycyrrhizae.
4. fat-reducing liver-protecting Chinese medicine composition according to claim 3, is characterized in that, in this Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 10-50 part, Radix Paeoniae Alba 8-30 part, Radix Glycyrrhizae 2-15 part, Fructus Crataegi 20-60 part, Radix Salviae Miltiorrhizae 20-60 part, Rhizoma Alismatis 2-12 part.
5. fat-reducing liver-protecting Chinese medicine composition according to claim 4, is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 12-40 part, Radix Paeoniae Alba 9-20 part, Radix Glycyrrhizae 3-10 part, Fructus Crataegi 25-45 part, Radix Salviae Miltiorrhizae 25-45 part, Rhizoma Alismatis 5-10 part.
6. fat-reducing liver-protecting Chinese medicine composition according to claim 5, is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 15-30 part, Radix Paeoniae Alba 10-15 part, Radix Glycyrrhizae 4-8 part, Fructus Crataegi 27-35 part, Radix Salviae Miltiorrhizae 26-40 part, Rhizoma Alismatis 7-9 part.
7. fat-reducing liver-protecting Chinese medicine composition according to claim 6, is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: 20 parts of Radix Bupleuri stem and leaf, 12 parts of the Radix Paeoniae Albas, 5 parts, Radix Glycyrrhizae, 30 parts of Fructus Crataegis, 30 parts of Radix Salviae Miltiorrhizaes, 8 parts of Rhizoma Alismatis.
8. according to the described fat-reducing liver-protecting Chinese medicine composition of claim 1-7 any one, it is characterized in that: described medicament, health product or food are decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, syrup, buccal tablet, chewable tablet, electuary, pill, drop pill or injection.
9. according to a kind of preparation method of the described soothing the liver skin care Chinese medicine composition of claim 1-7 any one, comprise the following steps:
(1) take in proportion Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis;
(2) raw material in step (1) is prepared into to extract or crude drug powder in the following manner:
A) be prepared into respectively extract or crude drug powder,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder,
C) whole mixed raw materials standby one-tenth extracts or crude drug powder;
(3) extract of gained raw material in step (2) or crude drug powder are mixed, make acceptable various pharmaceutical dosage form, health product or food.
10. the Radix Bupleuri stem and leaf has the application in the medicine of fat-reducing liver-protecting effect in preparation.
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