CN101961401B - A kind of compound traditional Chinese medicine composition with effect of losing weight, lowering fat and invigorating spleen - Google Patents

Abstract

The invention discloses a compound traditional Chinese medicine composition with effects of losing weight, reducing lipid, tonifying spleen and beautifying, which comprises 1-6 parts of lotus leaves, 1-6 parts of seaweed, 0.1-3 parts of rose, 0.5-4 parts of astragalus membranaceus, 0.5-4 parts of bighead atractylodes rhizome, 0.5-4 parts of poria cocos and 0.1-3 parts of hawthorn. The composition has effects of reducing weight, reducing blood lipid, invigorating spleen, and reducing weight, and can regulate blood and qi, promote blood circulation, and achieve skin caring effect. And has the advantages of safety, convenience, no toxic or side effect and low cost.

Description

A kind of compound traditional Chinese medicine composition with effect of losing weight, lowering fat and invigorating spleen

technical field

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a compound traditional Chinese medicine composition with the functions of reducing weight, lowering fat, invigorating the spleen and beautifying the skin. the

Background technique

With the rapid development of the global economy, human diet and nutritional status have been significantly improved. However, the more serious problem that followed was the imbalance of nutritional structure-obesity. Excessive accumulation of fat under the skin and around the organs is very harmful to people's health. It is mainly manifested in the obesity prone to coronary heart disease, High blood pressure, diabetes, etc. Obesity has been listed by the World Health Organization as one of the five major diseases that seriously endanger human health, and it has become the main "social medical problem" facing mankind in the new century. the

There are a wide variety of lipid-lowering and weight-loss drugs on the market, but most of them are chemical preparations. Some drugs can bring some obvious side effects, such as different degrees of liver damage, such as diarrhea, dizziness, vomiting, anorexia, etc. and other symptoms; some synthetic drugs have less toxic and side effects, but the effect is not good and they are easy to rebound; there are many kinds of compound Chinese medicines, but most of them contain laxatives such as rhubarb and Alisma, which can easily cause spleen deficiency and qi deficiency. In view of the above-mentioned problems and defects in the prior art, the object of the present invention is to provide a compound Chinese medicine composition for obese people to lose weight and reduce fat, and has the effect of invigorating the spleen and beautifying the skin. , and low cost. the

Contents of the invention

The technical solution for realizing the purpose of the above invention is a compound traditional Chinese medicine composition with the effects of losing weight, reducing fat, invigorating the spleen and beautifying the skin. The present invention is made by the raw material of following weight ratio:

1-6 parts of lotus leaves 1-6 parts of seaweed 0.1-3 parts of roses

Astragalus 0.5-4 parts Atractylodes 0.5-4 parts Poria cocos 0.5-4 parts

Hawthorn 0.1 to 3 parts. the

The weight proportion of each raw material of preferred formula of the present invention is:

2-4 parts of lotus leaves 2-4 parts of seaweed 0.3-1.5 parts of roses

Astragalus 1-2.5 parts Atractylodes 1-2.5 parts Poria cocos 1-2.5 parts

Hawthorn 0.3 to 1.5 parts. the

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts lotus leaf 3 parts seaweed 1 part rose

2 parts of Astragalus 2 parts of Atractylodes macrocephala 2 parts of Poria cocos

Hawthorn 1 part. the

In the above composition, the weight of the drug is calculated based on the crude drug, and the weight part is used as the proportion, which can be increased or decreased according to the proportion during production. For example, the unit of kilogram or ton can be used for large-scale production, and the unit of small-scale production The unit can also be gram or milligram, and the weight can be increased or decreased, but the weight ratio of the raw medicinal materials among the components remains unchanged. the

The above weight proportions are obtained through scientific screening, and the proportions of the constituents can be adjusted accordingly, and the increase or decrease does not exceed 100%, and the drug effect remains unchanged. the

The drug mechanism in the present invention is as follows:

Regarding the pathological mechanism of obesity, physicians of all dynasties believed that it was related to qi deficiency, phlegm, dampness, and stasis. Traditional Chinese medicine believes that the main pathogenesis is yin excess and yang deficiency, which is manifested as qi deficiency, which is yang deficiency, and yin excess, which is water-dampness, phlegm addiction, and lipid turbidity as symptoms, and qi deficiency is mainly caused by spleen and kidney dysfunction. Pathological basis, deficiency in origin and excess in superficiality. Mixed reality and fiction. Among qi deficiency, it is especially common in those with spleen and lung qi deficiency. People who are addicted to fat and sweet, glutinous rice cakes, lack of exercise, or old age and yin deficiency can easily lead to spleen and lung qi deficiency and insufficient spleen, so they cannot transport and transform. Insufficient lung qi, then can not promulgate and distribute compresses, resulting in stagnation of grain qi and body fluid in the body, blood forms ointment and phlegm dampness, accumulates in the skin, and becomes obese. Therefore, on the one hand, the present invention uses lotus leaves to lose weight and seaweed to reduce fat; the

Monarch drug: the drug in the prescription that mainly treats the main syndrome. the

Lotus leaf, bitter, astringent, flat. GUIXIN, liver, spleen channel. It has the effects of clearing away heat and relieving heat, promoting yang and stopping bleeding. It can treat heat and thirst, headache and dizziness, spleen deficiency and abdominal distension, stool and diarrhea, hematemesis and bleeding, postpartum lochia, Chiyou Huo Dan, etc. ("Dictionary of Traditional Chinese Medicine" edited by Nanjing University of Traditional Chinese Medicine Shanghai Science and Technology Press second edition page 2510). "Compendium of Materia Medica" contains: "The lotus leaf is taken, which makes people thin and thin. Taking it alone can eliminate yang, water and edema." The traditional Chinese medicine composition mainly uses it as the main medicine for weight loss. the

Seaweed, rich in alginic acid, can lower cholesterol in the human body. By hindering the absorption of cholesterol and promoting the consumption of cholesterol in the liver, it has a good effect of lowering blood lipids. the

Rose, sweet, slightly bitter, warm. Return liver, spleen channel. It can promote qi and relieve depression, harmonize blood and relieve pain. For pain in the liver and stomach, nausea due to lack of food, and pain from falling ("Chinese Pharmacopoeia"). It has the effect of promoting blood circulation and beauty. the

Ministerial drug: a drug that assists the monarch drug in the treatment of the main syndrome, or mainly in the treatment of concurrent syndromes. the

Astragalus, slightly warm in nature, sweet in taste, belongs to the spleen and lung meridian, has the functions of invigorating the spleen and invigorating the middle, raising yang and elevating depression, replenishing qi and strengthening the surface, and diuresis; it is used for fatigue, lack of food, loose stools, and edema caused by spleen deficiency , Diabetes, symptoms such as surface deficiency, spontaneous sweating, cough and asthma caused by lung qi deficiency. It is widely used in clinical practice, and has the functions of promoting body metabolism, anti-fatigue, and promoting the renewal of serum and liver proteins; it can enhance myocardial contractility, protect the cardiovascular system, resist arrhythmia, expand coronary arteries and peripheral blood vessels, lower blood lipids, and lower blood pressure , Reduce platelet adhesion, thereby reducing thrombus formation. the

Adjuvant medicine: adjuvant refers to the treatment of combined syndromes with monarch and minister medicine. the

Atractylodes macrocephala, nature and flavor are bitter, sweet, warm. Return spleen, stomach warp. It has the effects of invigorating the spleen and replenishing qi, drying dampness and diuresis, harmonizing miscarriage, solidifying the surface, antiperspirant, and anticancer. It can treat lung cancer, gastric cancer, cervical cancer, spleen deficiency, lack of food, abdominal distension and diarrhea, phlegm and water dizziness, edema, spontaneous sweating, fetal movement, asthma, phlegm cough, leucorrhea, white turbidity, spermatorrhea, gonorrhea, frequent urination, etc. (The Pharmacology and Application of Anticancer Chinese Medicine, edited by Ji Yubin, Heilongjiang Science and Technology Press, 1999 edition, page 447). the

Poria cocos is sweet, light and flat in nature. Guixin, spleen, lung, kidney channel. It has the effects of diuresis and dampness, invigorating the spleen and stomach, calming the mind and calming the nerves. It can treat dysuria, edema and fullness, cough with phlegm, vomiting, spleen deficiency, lack of food, diarrhea, palpitations, insomnia, forgetfulness, seminal emission and white turbidity. ("Dictionary of Chinese Medicine" edited by Nanjing University of Traditional Chinese Medicine Shanghai Science and Technology Press second edition page 2154). the

Atractylodes macrocephala is bitter and warm but good at drying dampness, Poria cocos is sweet and light but good at expelling dampness, and they are used together, one for dryness and one for exudation, to invigorate the spleen and dehumidify, and complement each other. the

Medication: the medicine that guides all medicines directly to the lesion, or reconciles all medicines. the

Hawthorn, medicinal properties are sour, sweet, slightly warm. Return spleen, stomach, liver channel. It has the effects of eliminating food and invigorating the stomach, promoting qi and dispelling addiction. It can treat food stagnation, abdominal distension and pain, diarrhea, dysentery, amenorrhea, postpartum abdominal pain, lochia, sore gas or swelling and pain of green pills, hyperlipidemia, etc. ("Dictionary of Chinese Medicine" edited by Nanjing University of Traditional Chinese Medicine Shanghai Science and Technology Press second edition page 226). the

The preparation method of the present invention can adopt the traditional Chinese medicine decoction method to obtain the extract for human consumption. First take 50-100g of the medicine according to the above ratio, mix it and put it into a container for decocting traditional Chinese medicine. the

The medicine of the present invention can be prepared into any conventional oral preparation by adopting conventional methods of traditional Chinese medicine preparations. For example, the extract powders of these raw materials can be uniformly mixed to make tea. The active components of the medicine of the present invention can also be prepared into any commonly used oral dosage form, such as granules Potions, pills, powders, tablets, capsules and oral liquids, etc. the

Clinical use result of medicine of the present invention shows, has following advantage:

1. The components of the Chinese herbal medicine selected by the present invention meet the requirements of the "Notice of the Ministry of Health on Further Standardizing the Management of Health Food Raw Materials", and use the comprehensive effects of various Chinese medicines to lose weight and are nontoxic and harmless to the human body. The animal acute toxicity test shows that the tested animals have no toxic reaction, and the main organs have no obvious changes, and the drug is safe and reliable. the

2. The present invention is rich in various trace elements such as glucose, organic acids, vitamins, amino acids, etc., which is beneficial for human body to absorb and enhance physical fitness. the

3. The present invention has the characteristics of simple manufacture, convenient administration and low price. the

Detailed ways:

Experimental verification:

1. Measure the body weight (initial weight and final weight) and body length of each group of mice before and after administration respectively, and calculate the Liss index before and after administration (see Table 1). the

As shown in the table, the body weight of each group of mice has increased; except for the normal group, the Liss index of the mice in the II～V groups has increased, which is significant (P<0.01) relative to the normal group; As for model group II, the Lees index in groups III, IV, and V was relatively low (P<0.05); however, there was no significant difference among groups III, IV, and V. Show that medicine of the present invention and sibutriline group have the same reducing effect on the Lees index of mice. the

Table 1 Body weight and Liss index of mice in each group before and after administration

Note: Compared with the normal control group, ▲P<0.01; compared with the model control group, *P<0.01, #P<0.05; compared with the positive control group, ◆P>0.05. the

2. After intragastric administration for 30 days, the blood was collected by picking the eyeball, and after processing to obtain the serum, the concentrations of TG, CHO, and HDL-C in the serum of mice in each group were measured with an ultraviolet spectrophotometer (see Table 2). the

The data in the table shows that the concentration levels of TG, TCH and HDL-C in the hyperlipidemia model group are significantly higher than those in the normal control group (P<0.05), which means that the hyperlipidemia and obesity model in mice has been successfully established in terms of blood lipids. TG level: the positive control group was significantly lower than other groups (P<0.05), the drug group was higher than Group III but lower than Group I and II (P<0.05); TCH level: Sibutrilamine group was significantly lower than the high-fat model group (P<0.05), drug group IV and group III were not significantly different (P>0.05) but significantly lower than the high-fat model group (P<0.05); HDL-C concentration level: relative to the high-fat model group, III, Groups IV and V were significantly lower (P<0.05), among which the high-fat model group was the highest, the drug group was lower than the high-fat model group (P<0.05), but higher than I and II groups (P<0.01). It shows that the present invention has better effect of lowering blood fat. the

Table 2 Blood lipid levels in each group of mice after administration

P＜0.05；与西布曲名组相比，◆P＜0.05，★P＞0.05。  Note: Compared with the normal control group, ▲P<0.01, *P<0.05; compared with the high-fat model group,

P<0.05; compared with Xibutuquming group, ◆P<0.05, ★P>0.05.

3. After 30 days of continuous administration, the body weight of the mice was measured every three days. See Table 3 for the body weight and body weight changes of the mice in each group before and after administration. the

The data in the table shows that the body weight growth rate of the high-fat model group is the largest in the II～V groups fed with high-fat feed (P<0.01), the difference between the sibutril group and the common group is not significant (P>0.05), and the body weight of the drug group The growth rate was significantly lower than that of groups II and III. The growth rate of body weight reflects the degree of obesity to a certain extent, and it can be seen that the medicine of the present invention has the effect of reducing weight. the

Table 3 Body weight growth rate of mice in each group before and after administration

P＜0.05；与高脂模型组相比，*P＜0.01，#P＜0.05；与西布曲名组相比，◆P＜0.05。  Note: Compared with the normal control group, ▲P<0.01,

P<0.05; compared with the high-fat model group, *P<0.01, #P<0.05; compared with the Sibutramine group, ◆P<0.05.

4. After 30 days of administration, the mice were killed, and the abdominal mesentery and perirenal fat pads were taken, and the fat weight was weighed to calculate the fat coefficient of the mice in each group (see Table 4). the

As shown in the table, compared with the ordinary control group, groups II-V were all significant (P<0.05). Compared with the high-fat model group mice, the fat index of the sibutramine group was not significant (P>0.05), and it was far greater than that of the normal group; while the drug group (IV, V) was lower than that of the II and III groups ( P<0.05) but higher than group I. Show that this medicine can reduce body fat weight, has the effect of reducing weight. the

Table 4 Fat index after administration of each group of mice

Note: Compared with normal control group, *P<0.05; compared with high-fat model group, ▲P<0.05, #P>0.05;

5. Physiological and mental state observation of mice in each group during the administration period

The mice in the normal group were in good mental state on weekdays; their coat color was moist and clean; their food and water intake were normal; their feces were normal. The mice in the high-fat model group were in low spirits, lethargic, and did not like to exercise; their coat color was slightly yellow, greasy in clusters; their appetite ranged from strong to poor, and their stools were normal. The Xibutuqu group was depressed, drowsy, and restless; their coat color was yellow and greasy in clusters; their appetite was poor; their stools were light in color. The mental state of the drug group was good; the hair color was moist, clean and tidy; the food and drinking water were normal; the stool color was dark. It shows that the medicine of the present invention has no toxic and side effects on the body, and has higher safety compared with sibutril, which has stronger side effects. the

6. After the mice were fasted for 16 hours, each group was infused with drugs 30 minutes before the experiment, and the mice were put into a bucket filled with water with a diameter of about 30 cm and a depth of about 40 cm. The water depth was about 20 cm and the water temperature was 28°C. Mice were judged as drowning when they swam in the water until they were too fatigued and their nostrils were just submerged under water. The time from entering the water to drowning of the mice was used as the index of fatigue endurance test. Swimming time of each group of mice in the fatigue test after administration (see Table 5). the

The data in the table shows that the swimming time of the drug group is much longer than that of the high-fat model group and the sibutril group (P<0.01), indicating that the drug has a good spleen-invigorating effect and can prolong the fatigue endurance time of mice. the

Table 5 Swimming time of mice in each group after administration

P＜0.05；与西布曲名组相比，◆P＜0.01。  Note: Compared with the normal control group, ▲P<0.05; compared with the high-fat model group,

P<0.05; compared with Xibutuquming group, ◆P<0.01.

Hereinafter, the present invention will be described more specifically by way of examples. However, the scope of the present invention is not limited to these examples. the

Example 1

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 30, seaweed 30, rose 10, astragalus 20, Atractylodes macrocephala 20, poria cocos 20, hawthorn 10. the

Wash the drug, mix and boil, boil the drug twice, 1 hour each time, filter the residue to get the juice, dry the obtained liquid below 55°C to make an extract, add auxiliary materials to make a dry powder that passes through a 100-mesh sieve, and pack it in a vacuum bag after sterilization Vested. Drink with warm water when needed. the

Example 2

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 20, seaweed 40, rose 5, astragalus 25, Atractylodes macrocephala 25, poria cocos 25, hawthorn 5. the

Wash the drug, mix and boil, boil the drug twice, 1 hour each time, filter the residue to get the juice, dry the obtained liquid below 55°C to make an extract, add auxiliary materials to make a dry powder through a 100-mesh sieve, and fill the capsule after sterilization Vested. the

Example 3

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 10, seaweed 50, rose 10, astragalus 10, Atractylodes macrocephala 30, poria cocos 30, hawthorn 10. the

Wash the drug, mix and boil, boil the drug twice, each time for 1 hour, filter the residue to get the juice, and dry the obtained liquid below 55°C to make an extract, add auxiliary materials to make a dry powder through a 100-mesh sieve, and add auxiliary materials to make a pill. Can. the

Example 4

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 40, seaweed 20, rose 10, astragalus 40, Atractylodes macrocephala 15, poria cocos 15, hawthorn 10. the

Wash the drug, mix and boil, boil the drug twice, 1 hour each time, filter the residue to get the juice, dry the obtained liquid below 55°C to make an extract, add auxiliary materials to make a dry powder that passes through a 100-mesh sieve, and pack it in a vacuum bag after sterilization Vested. Drink with warm water when needed. the

Example 5

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 50, seaweed 10, rose 10, astragalus 20, Atractylodes macrocephala 10, poria cocos 10, hawthorn 10. the

Example 6

Weigh raw materials according to the following proportions (unit: kg)

Lotus leaf 60, seaweed 60, rose 15, astragalus 5, Atractylodes macrocephala 5, Poria cocos 5, hawthorn 15. the

Example 7

Weigh raw materials according to the following ratio (unit: g)

Lotus leaf 20, seaweed 40, rose 10, astragalus 40, Atractylodes macrocephala 15, poria cocos 15, hawthorn 10. the

Claims (3)

1. herbal mixture compositions with Weight-reducing and lipid-lowering spleen invigorating effect is characterized in that it is processed by the following weight proportion raw material:

0.1～3 part of 1～6 portion of Flos Rosae Rugosae of 1～6 portion of Sargassum of Folium Nelumbinis

0.5～4 part in 0.5～4 part of Poria of 0.5～4 part of Rhizoma Atractylodis Macrocephalae of the Radix Astragali

0.1～3 part of Fructus Crataegi.

2. the herbal mixture compositions with Weight-reducing and lipid-lowering spleen invigorating effect according to claim 1 is characterized in that it is processed by the following weight proportion raw material:

0.3～1.5 part of 2～4 portions of Flos Rosae Rugosae of 2～4 portions of Sargassums of Folium Nelumbinis

1～2.5 part in 1～2.5 part of Poria of 1～2.5 part of Rhizoma Atractylodis Macrocephalae of the Radix Astragali

0.3～1.5 part of Fructus Crataegi.

3. the herbal mixture compositions with Weight-reducing and lipid-lowering spleen invigorating effect according to claim 1 is characterized in that it is processed by the following weight proportion raw material:

1 part of 3 portions of Flos Rosae Rugosae of 3 portions of Sargassums of Folium Nelumbinis

2 parts in 2 parts of Poria of 2 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Astragali

1 part of Fructus Crataegi.