CN108143974A - Relieving alcoholism and protecting liver ball - Google Patents

Relieving alcoholism and protecting liver ball Download PDF

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Publication number
CN108143974A
CN108143974A CN201810143209.1A CN201810143209A CN108143974A CN 108143974 A CN108143974 A CN 108143974A CN 201810143209 A CN201810143209 A CN 201810143209A CN 108143974 A CN108143974 A CN 108143974A
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relieving alcoholism
protecting liver
radix
liver
medicinal powder
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钟莉华
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract

The present invention relates to relieving alcoholism and protecting liver balls, belong to the technical field of Traditional chinese medicine medicament, and raw material is made of pueraria lobata, flower of kudzuvine, mung bean, hawthorn, malt, radix bupleuri, peppermint, cassia seed, Radix Paeoniae Alba, dried orange peel, Poria cocos, rhizoma alismatis, Radix Notoginseng, Radix Salviae Miltiorrhizae, American Ginseng.The technical program provide relieving alcoholism and protecting liver ball have protective effect to liver and stomach, make user reach drink after be not easy it is liquor-saturated;Be not easy to have a headache, nausea and vomiting, abdominal distension, abdominal pain, diarrhea;It sobers up time fast effect than before, there are apparent sobering-up functions, and effectively slow down dizzy, headache, the phenomenon that stomach is felt bad.

Description

Relieving alcoholism and protecting liver ball
Technical field
The invention belongs to the technical fields of Traditional chinese medicine medicament.
Background technology
It is dinner party and health care phenomenon that our people often has to drink, and alcoholism is commonly called as drunk, and alcohol (ethyl alcohol) is once drunk With inhibiting effect after a large amount of inebriant meeting Central nervous system generation first excitement, severe intoxication can make breathing, heartbeat suppression System and it is dead.Alcoholism be as caused by the factors such as heredity, physical condition, psychology, environment and society, but just individual and Speech differs greatly, everyone capacity for liquor is variant, and after alcohol enters human body, liver must be busy, first first turns ethyl alcohol Acetaldehyde is turned to, finally carbon dioxide is decomposed into again and water excretes, this process needs the participation of a variety of enzymes and vitamin, this A little processes carry out all in liver, so in fact, drunk is the ability solution not wine for the amount of drinking that relieves the effect of alcohol of liver.
The harmfulness of alcohol each organ to human body is very big, but in most cases, most fast and most directly reflect It is the symptoms such as headache, dizziness, obnubilation and vomiting, people are most concerned with to eliminate when drinking the appearance of these symptoms, So to take containing the classes substance such as sedative, hormone, in the hope of sensuously can be more comfortable.Actually these substances are to pass through fiber crops Numbness nervous system is allowed to calm, numb, seems awake, but after drug effect on drunk person surface to achieve the effect that allow, the signs of getting drunk are again It can reproduce, and body is empty, energy is not concentrated, it is often more important that, internal alcohol still has, and continues with playing injury human body Effect.
In daily life, people often drink beyond one's capacity due to need of work, some can also be formed it is drunk, to body generate Adverse effect, specifically can behave as following aspects:
1st, it drinks the direct impariment of the liver, alcoholic liver, hepatitis, hepatic sclerosis, after damage of the liver, eyesight necessarily declines, body removing toxic substances energy Power also declines, and causes immunity degradation, easily infects other diseases and tumour.
2nd, it drinks and injures one's stomach, digestion is bad, and constitution also easily infects other diseases with regard to poor.
3rd, heart, spleen, pancreas can also be injured by drinking, and easily cause hypertension, cardiovascular disease, apoplexy and pancreatitis.
4th, drinking can be impairment of the kidney, and cause prostatitis, influence sexual function.
5th, it drinks and overtaxes one's nerves through the people often to indulge in excessive drinking can generate the dependence to wine, and temper becomes irascible, uneasy.
6th, it drinks and injures appearance, the people's appearance being on the drink is withered, wan and sallow, skin also easy aging.
In recent years, have the listing of the report and product of medicines and health protection food, beverage and drug much relieved the effect of alcohol, it is such as open " the Antialcoholic liver-protecting oral liquid " that number CN1058907A patent applications are prepared using hoveniae semoveniae semen, Schisandra chinensis, pueraria lobata;Publication number " a kind of pure natural shield of relieving the effect of alcohol that CN1238036C patent applications are prepared with pueraria lobata, hoveniae semoveniae semen, dried orange peel, mountain quarrel, corn stigma, Poria cocos Instant granules for protecting liver ".But the effect of the product that relieves the effect of alcohol of different formulations has very big difference.Though moreover, there is various relieve the effect of alcohol currently on the market The product sobered up, but effect is little, and effect is not good enough yet.But most products are more there are indication, and therapeutic domain is wide, and curative effect is unknown Really, the shortcomings of specific aim is not strong.And many products are only effective to pre- preventing drunkenness, taken after drunk then ineffective;Or it only notes Weight liver protecting, to blood alcohol concentration higher after drinking without rapid and apparent improvement result.
Invention content
The invention is intended to provide relieving alcoholism and protecting liver ball, to solve, relieving alcoholism and protecting liver is ineffective in the prior art or can only prevent The problem of drunk.
In order to achieve the above object, base case of the invention provides relieving alcoholism and protecting liver ball, is matched by following components quality The raw material of ratio:Pueraria lobata 20-30, flower of kudzuvine 15-30, mung bean 15-30, hawthorn 20-30, malt 20-30, radix bupleuri 6-20, peppermint 6-15, Cassia seed 20-30, Radix Paeoniae Alba 10-30, dried orange peel 6-15, Poria cocos 20-30, rhizoma alismatis 10-20, Radix Notoginseng 6-15, Radix Salviae Miltiorrhizae 20-30, American Ginseng 6-20 is formed.
The technical principle of this programme is:Pueraria lobata:Returns spleen, stomach;Can expelling pathogenic factors from muscles and skin bring down a fever, treating measles promote the production of body fluid to quench thirst, and rising Yang stops It rushes down.
Flower of kudzuvine:Returns spleen, stomach;Kind relieving alcoholism, is amusing and stomach;Suitable for insobriety, headache is dizzy, and polydipsia, chest diaphragm is satisfied Swollen, acid regurgitation etc. injures the disease of stomach Qi.
Mung bean:The thoughts of returning home, stomach;It is clearing heat and detoxicating, diuresis of relieving summer heat.It is usually used in hot summer weather polydipsia.
Hawthorn:Returns spleen, stomach, Liver Channel;Promoting digestion and removing indigestion, scattered stasis;Hawthorn has the stagnant work(of disperse accumulationization, particularly digests greasy meat The stagnant key medicine of dyspepsia.
Malt:Returns spleen, stomach, Liver Channel;Food digesting stomach fortifying, delaactation dissipate-swelling, soothing liver-qi stagnation;Malt food digesting stomach fortifying, and can soothing the liver solution It is strongly fragrant, it, also can be with other Calming liver to disperse Qi decoction with use for the hypochondriac pain of irritability stasis or liver-stomach disharmony, abdominal pain etc..
Radix bupleuri:Return liver, gallbladder channel;Evacuation is brought down a fever, soothing liver-qi stagnation, yang invigorating.
Peppermint:Return lung, Liver Channel;Dispelling wind and heat from the body, head clearing, relieving sore-throat, promoting eruption, soothing liver-qi stagnation.
Cassia seed:Return liver, kidney, large intestine channel;It clears liver and improve vision, relaxes bowel;Cassia seed sweet and cool-natured is clear and rich, can removing heat from the liver and The beneficial liver-yin of energy, is longer than improving eyesight.
Radix Paeoniae Alba:Return liver, the spleen channel;Nourishing blood for regulating menstruation, smooth liver and relieve pain, astringing YIN to stop sweating;Radix Paeoniae Alba enters Liver Channel, can blood-nourishing hold back it is cloudy to mend The deficiency of liver body, but can the soft liver of soothing the liver with let out liver use after.
Dried orange peel:Returns spleen, lung channel;Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.
Poria cocos:The thoughts of returning home, spleen, kidney channel;Clearing damp and promoting diuresis, spleen-benefiting mind-tranquilizing.
Rhizoma alismatis:Return kidney, bladder warp;Clearing damp and promoting diuresis is purged heat.
Radix Notoginseng:Return liver, stomach;Removing blood stasis and hemostasis, analgesic therapy of invigorating blood circulation.
Radix Salviae Miltiorrhizae:Converge to heart and liver channels;Promoting blood circulation for regulating menstruation, cool blood to disappear carbuncle are calmed the nerves.
American Ginseng:The thoughts of returning home, lung, kidney channel;Boosting qi and nourishing yin relieves inflammation or internal heat and promotes the production of body fluid;American Ginseng boosting qi and nourishing yin in sweet flavor, bitter-cold herbs expelling heat drop Fire, it is kind to control deficiency of both qi and yin and Sheng person and lung-kidney deficiency hyperactivity of fire person in excess fire;It is usually used in impairment of both QI and YIN, it is tired tired, it is thirsty;American Ginseng is mended The power of gas is longer than yin-nourishing and relieves inflammation or internal heat and promote the production of body fluid not as good as ginseng.
There is preferable dispelling effects of alcohol, and be capable of effective protection user's using obtained relieving alcoholism and protecting liver ball is matched above Liver and stomach.
Advantageous effect:1st, formula safety, all Effect raw materials meet health ministry food security standard;2nd, using this The relieving alcoholism and protecting liver ball that technology is produced can be taken before drinking, and can work in 30min-60min, and user is drinking In the process, brains more regains consciousness, is not easy to feel dizzy, does not interfere with appetite, it is not easy to it is existing to generate nausea and vomiting and part etc. As;3rd, the relieving alcoholism and protecting liver ball is taken during drinking, can work in 30min-60min, the disease that One's head is splitting can be alleviated Shape, the phenomenon that reducing gasteremphraxis, have a stomachache, keck, brains can restore certain and regain consciousness;4th, it takes, has more after drinking multibreak Apparent sobering-up functions can effectively slow down dizzy, headache, the phenomenon that stomach is felt bad;5th, take at the beginning " pueraria lobata, flower of kudzuvine, mung bean, Hawthorn, malt " is to have the function that sober up, improving appetite and invigorating spleen, preventing or arresting vomiting, but smell is laid particular stress on, dry is hot, dispelling effects of alcohol unobvious; After being added to " radix bupleuri, peppermint, cassia seed, Radix Paeoniae Alba, dried orange peel " again, it is existing to reduce headache, gasteremphraxis pain, nausea and vomiting etc. after drinking As, and haved the function that head clearing, soothing liver-qi stagnation, liver protecting, however the smell of drug is still than heavier;Increase again " Poria cocos, rhizoma alismatis, Radix Notoginseng, Radix Salviae Miltiorrhizae " four traditional Chinese medicine material, reaches excreting dampness diuresis by " Poria cocos, rhizoma alismatis ", accelerates the metabolism of alcohol, leads to It crosses " Radix Notoginseng, Radix Salviae Miltiorrhizae " to have the function that promoting blood circulation and removing blood stasis, analgesic, calm the nerves, further alleviates the feelings of abdominal distension stomachache after drinking, headache Condition, however still remain thirsty, irritated, irritability symptom;To solve the symptom, tonifying Qi drugs for nourishing yin is increased, it is such as " Radix Astragali, big Jujube, sealwort, matrimony vine ", the pill produced is excessively thick greasy, and manufacturing process medium viscosity is big, easily burns out making machine, use instead for Solves problem above after " American Ginseng ", the pill viscosity produced is small, and can effectively solve thirsty, irritated, irritability symptom. The technical program provide relieving alcoholism and protecting liver ball have protective effect to liver and stomach, make user reach drink after be not easy it is liquor-saturated;It is not easy head Bitterly, nausea and vomiting, abdominal distension, abdominal pain, diarrhea;It sobers up time fast effect than before, there are apparent sobering-up functions, and effectively subtract Dizzy, headache is delayed, the phenomenon that stomach is felt bad.
Further, the amounts of components of each raw material is:Pueraria lobata 30, flower of kudzuvine 30, mung bean 30, hawthorn 20, malt 20, radix bupleuri 15th, peppermint 15, cassia seed 20, Radix Paeoniae Alba 15, dried orange peel 15, Poria cocos 20, rhizoma alismatis 20, Radix Notoginseng 15, Radix Salviae Miltiorrhizae 20, American Ginseng 20;Use with The relieving alcoholism and protecting liver ball that the ratio of upper component is produced, dispelling effects of alcohol more preferably, and can effectively have the function that liver protection.
Further, the relieving alcoholism and protecting liver ball can be made into the shape of pill, capsule, particle, decoction of medicinal ingredients, chewable tablets and oral liquid Formula;The technical program can be provided to relieving alcoholism and protecting liver medicine and be fabricated to different drug forms, so as to adapt to the hobby of different people, improve this The sales volume of drug.
A kind of method for preparing relieving alcoholism and protecting liver ball, includes the following steps:
(1) it is milled after taking the raw material drying of relieving alcoholism and protecting liver ball, and is put into disinfection basin and sterilizes;
(2) 1 is pressed with the weight of medicinal powder:The ratio of 1-1.5 gets out honey;
(3) it tempers honey, with high heat first, endures and be changed to slow boiling after boiling and delay endure;
(4) honey tempered is poured into spoon in the medicinal powder in step (1) on one side, medicinal powder is stirred on one side, Until stop adding honey when can't see dry medicinal powder;
(5) honey in step (4) and the mixture of medicinal powder are twisted into strip, and are pellet with hand group, it is dry by what is got ready Net film is by the drug packages of pellet.
The relieving alcoholism and protecting liver ball production efficiency prepared using more than technology is high, and will not damage and produce instruments, and can prepare this Method is bulk to copy to factory, is processed and makes, and the relieving alcoholism and protecting liver ball that this production method is produced can effectively reach The effect of relieving alcoholism and protecting liver improves alcohol and decomposes enzymatic activity, and acceleration of alcohol catabolism improves upset,gastro-intestinal etc. after drinking.
Further, in step (2) 1 is pressed with the weight of medicinal powder:1.5 ratio gets out honey;Using 1:1.5 ratio is accurate Standby honey can ensure the dosage of honey, while in mass production manufacturing process, can put into next time in use, will not wave Take honey.
Specific embodiment
Relieving alcoholism and protecting liver ball of the present invention is further described with reference to specific embodiment, but does not limit the protection of the present invention Range and application range:
First, for the specific embodiment of relieving alcoholism and protecting liver ball of the present invention
The raw material components consumption proportion table (unit of 1 relieving alcoholism and protecting liver ball of table:Part)
It is specifically addressed with embodiment 4, the present embodiment relieving alcoholism and protecting liver ball, raw material matches dosage system according to following components It forms:Pueraria lobata 30, flower of kudzuvine 30, mung bean 30, hawthorn 20, malt 20, radix bupleuri 15, peppermint 15, cassia seed 20, Radix Paeoniae Alba 15, dried orange peel 15th, Poria cocos 20, rhizoma alismatis 20, Radix Notoginseng 15, Radix Salviae Miltiorrhizae 20, American Ginseng 20.
The above-mentioned method for preparing relieving alcoholism and protecting liver ball, includes the following steps:
(1) it is milled after taking the raw material drying of relieving alcoholism and protecting liver ball, and is put into disinfection basin and sterilizes;
(2) 1 is pressed with the weight of medicinal powder:1.5 ratio gets out honey;
(3) it tempers honey, with high heat first, endures and be changed to slow boiling after boiling and delay endure;
(4) honey tempered is poured into spoon in the medicinal powder in step (1) on one side, medicinal powder is stirred on one side, Until stop adding honey when can't see dry medicinal powder;
(5) honey in step (4) and the mixture of medicinal powder are twisted into strip, and are pellet with hand group, it is dry by what is got ready Net film is by the drug packages of pellet to get to the relieving alcoholism and protecting liver ball of the technical program.
Compared with Example 4, difference lies in the transformation of corresponding steps parameter for Examples 1 to 3 and comparative example 1~7;
Compared with Example 4, difference lies in pueraria lobata 20, flower of kudzuvine 15, mung bean 15, radix bupleuri 6, peppermint 6, Radix Paeoniae Albas for embodiment 1 10th, dried orange peel 6, rhizoma alismatis 10, Radix Notoginseng 6, American Ginseng 6;
Compared with Example 4, difference lies in, pueraria lobatas 25, flower of kudzuvine 20, mung bean 20, hawthorn 25, malt 25, thin for embodiment 2 Lotus 10, cassia seed 25, Radix Paeoniae Alba 20, dried orange peel 10, Poria cocos 25, rhizoma alismatis 15, Radix Notoginseng 10, Radix Salviae Miltiorrhizae 25, American Ginseng 10;
Embodiment 3 compared with Example 4, difference lies in, hawthorn 30, malt 30, radix bupleuri 20, cassia seed 30, Radix Paeoniae Alba 30, Poria cocos 30, Radix Salviae Miltiorrhizae 30;
Compared with Example 4, difference lies in be not added with medicinal material to comparative example 1 in comparative example 1;
Compared with Example 4, difference lies in Poria cocos 25, rhizoma alismatis 15 for comparative example 2;
Compared with Example 4, difference lies in Radix Notoginseng 6, Radix Salviae Miltiorrhizaes 30 for comparative example 3;
Compared with Example 4, difference lies in American Ginsengs 15 for comparative example 4;
Compared with Example 4, difference lies in Poria cocos 30, rhizoma alismatis 10 for comparative example 5;
Compared with Example 4, difference lies in Radix Notoginseng 10, Radix Salviae Miltiorrhizaes 25 for comparative example 6;
Compared with Example 4, difference lies in American Ginsengs 17 for comparative example 7.
2nd, pharmacodynamics test
1st, test material:The above-mentioned embodiment 1-8 samples prepared;Alcohol selects 55 ° of Red Star strong, colourless liquor distilled from sorghum white wine.
2nd, animal:Healthy mice 110, male, 6-8 week old, 30 ± 2g of weight are fed, free water with normal diet And feed.
3rd, animal packet:Mouse is randomly divided into 11 groups (every group 10), respectively 1 group of embodiment, 2 groups of embodiment, implementation 3 groups of example, 4 groups of embodiment, comparative example 1 group (blank control group), 2 groups of comparative example, 3 groups of comparative example, 4 groups of comparative example, comparative example 5 Group, 6 groups of comparative example, 7 groups of comparative example.
4th, detection method:Embodiment 1-4 groups first distinguish 55 ° of Red Star strong, colourless liquor distilled from sorghum white wine (1.45g/kg) of feeding, after half an hour The sample (6g/kg) of feeding embodiment 1-4 again;1 group of comparative example (blank control group) feeds physiological saline;Comparative example 2-7 groups are first divided Other 55 ° of Red Star strong, colourless liquor distilled from sorghum white wine (1.45g/kg) of feeding, the sample (6g/kg) of feeding comparative example 2-7 again after half an hour.
Small white mouse in above example 1-4 groups, comparative example 1 group (blank control group) and comparative example 2-7 groups, which uses, wins Eyeball takes blood, and separation serum Cord blood is to be checked.
5th, result of the test:
(1) ordinary circumstance is observed:1 group of (blank control group) hair of comparative example is glossy, and figure is active, and sensitivity is good, food Amount and stool are normal;Embodiment 1-3 groups hair is compared with gloss, and figure is general, and sensitivity is preferable, and appetite and stool are normal;Embodiment 4 Group hair is glossy, and figure is active, and sensitivity is good, and appetite and stool are normal;Comparative example 2-6 group hair luster degree is poor, figure compared with Slow, sensitivity is poor, and appetite is few, and stool is diluter.
(2) detection case is observed:Serum ALT, AST compare:Refer to table 2.
Table 2
6. conclusion:ALT, AST are destroyed the enzyme released afterwards by liver cell, this experiment passes through in mice serum The measure of the representative enzyme of ALT, AST can reflect the inflammation or necrotic lesion of liver system, by above-mentioned experiment, as a result table It is bright:Relieving alcoholism and protecting liver ball prepared by the present invention can effectively reduce mice serum ALT, AST level.The embodiment of the present invention 4 is optimal Scheme has apparent antialcoholism action, protects liver cell, mitigates damage of the alcohol to liver cell.
3rd, clinical practice
Relieving alcoholism and protecting liver ball of the present invention was once used to treating and observing 65 patients or volunteer.By the above-mentioned implementation prepared 4 pill of example, for before drinking, drink in and different phase after drinking, usage and dosage:9-11 grams/times of pill commonly uses agent Amount 9g/ times, single maximum dose are not more than 30g, are taken with warm water.Before drinking, drink in and take after drinking.Knot Fruit:After clinical practice, more than patient or volunteer can reach drink after be not easy it is liquor-saturated;Be not easy to have a headache, nausea and vomiting, abdomen Swollen, abdominal pain, diarrhea;Sober up time fast effect than before, there are apparent sobering-up functions, and effectively slow down dizzy, headache, The phenomenon that stomach is felt bad.
Above-described is only the embodiment of the present invention, and the common sense such as well known concrete structure and characteristic are not made herein in scheme Excessive description.It, without departing from the structure of the invention, can be with it should be pointed out that for those skilled in the art Several modifications and improvements are made, these should also be considered as protection scope of the present invention, these all do not interfere with what the present invention was implemented Effect and practical applicability.The scope of protection required by this application should be based on the content of the claims, in specification The records such as specific embodiment can be used for explaining the content of claim.

Claims (5)

1. relieving alcoholism and protecting liver ball, it is characterised in that:Its raw material by following components quality proportioning:It is pueraria lobata 20-30, flower of kudzuvine 15-30, green Beans 15-30, hawthorn 20-30, malt 20-30, radix bupleuri 6-20, peppermint 6-15, cassia seed 20-30, Radix Paeoniae Alba 10-30, dried orange peel 6-15, Poria cocos 20-30, rhizoma alismatis 10-20, Radix Notoginseng 6-15, Radix Salviae Miltiorrhizae 20-30, American Ginseng 6-20 compositions.
2. relieving alcoholism and protecting liver ball according to claim 1, it is characterised in that:The amounts of components of each raw material is:Pueraria lobata 30, Pueraria lobota Spend 30, mung bean 30, hawthorn 20, malt 20, radix bupleuri 15, peppermint 15, cassia seed 20, Radix Paeoniae Alba 15, dried orange peel 15, Poria cocos 20, rhizoma alismatis 20, Radix Notoginseng 15, Radix Salviae Miltiorrhizae 20, American Ginseng 20.
3. relieving alcoholism and protecting liver ball according to claim 2, it is characterised in that:The relieving alcoholism and protecting liver ball can be made into pill, glue Capsule, particle, decoction of medicinal ingredients, chewable tablets and oral liquid form.
A kind of 4. method for preparing relieving alcoholism and protecting liver ball as described in claim 1, it is characterised in that:Include the following steps:
(1) it is milled after taking the raw material drying of relieving alcoholism and protecting liver ball, and is put into disinfection basin and sterilizes;
(2) 1 is pressed with the weight of medicinal powder:The ratio of 1-1.5 gets out honey;
(3) it tempers honey, with high heat first, endures and be changed to slow boiling after boiling and delay endure;
(4) honey tempered is poured into spoon in the medicinal powder in step (1) on one side, medicinal powder is stirred on one side, until Stop when can't see dry medicinal powder plus sweet;
(5) honey in step (4) and the mixture of medicinal powder are twisted into strip, and are pellet with hand group, it is clean thin by what is got ready Film is by the drug packages of pellet.
5. the method for relieving alcoholism and protecting liver ball according to claim 4, it is characterised in that:Step is pressed in (2) with the weight of medicinal powder 1:1.5 ratio gets out honey.
CN201810143209.1A 2018-02-11 2018-02-11 Relieving alcoholism and protecting liver ball Pending CN108143974A (en)

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CN109568532A (en) * 2019-01-18 2019-04-05 武汉太福制药有限公司 A kind of ageratum-liquid and preparation method thereof to relieve the effect of alcohol that helps digestion
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108888725A (en) * 2018-07-27 2018-11-27 蒲家蕤 Relieving alcoholism and protecting liver oral solution and preparation method thereof
CN109568532A (en) * 2019-01-18 2019-04-05 武汉太福制药有限公司 A kind of ageratum-liquid and preparation method thereof to relieve the effect of alcohol that helps digestion
CN111000219A (en) * 2019-11-26 2020-04-14 邳州高新区生物医药研究院有限公司 Liver-protecting pill and preparation method thereof

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Application publication date: 20180612