CN111000219A - Liver-protecting pill and preparation method thereof - Google Patents
Liver-protecting pill and preparation method thereof Download PDFInfo
- Publication number
- CN111000219A CN111000219A CN201911170856.2A CN201911170856A CN111000219A CN 111000219 A CN111000219 A CN 111000219A CN 201911170856 A CN201911170856 A CN 201911170856A CN 111000219 A CN111000219 A CN 111000219A
- Authority
- CN
- China
- Prior art keywords
- parts
- liver
- protecting
- honey
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 244000019459 Cynara cardunculus Species 0.000 claims abstract description 21
- 235000019106 Cynara scolymus Nutrition 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 235000016520 artichoke thistle Nutrition 0.000 claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 18
- 244000269722 Thea sinensis Species 0.000 claims abstract description 13
- 244000183278 Nephelium litchi Species 0.000 claims abstract description 12
- 235000009569 green tea Nutrition 0.000 claims abstract description 12
- 240000000249 Morus alba Species 0.000 claims abstract description 11
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 11
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 10
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 10
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 10
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 10
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 10
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 10
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 10
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 10
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 10
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 10
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 10
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims abstract description 3
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 3
- 235000012907 honey Nutrition 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000000243 solution Substances 0.000 claims description 26
- 238000009835 boiling Methods 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- 239000012535 impurity Substances 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 7
- 239000006260 foam Substances 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000003825 pressing Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 5
- 235000003230 Helianthus tuberosus Nutrition 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 6
- 230000002633 protecting effect Effects 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 4
- 210000000936 intestine Anatomy 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 241000245665 Taraxacum Species 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- YDDUMTOHNYZQPO-UHFFFAOYSA-N 1,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-4,5-dihydroxycyclohexanecarboxylic acid Natural products OC1C(O)CC(C(O)=O)(OC(=O)C=CC=2C=C(O)C(O)=CC=2)CC1OC(=O)C=CC1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-UHFFFAOYSA-N 0.000 description 2
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 2
- SITQVDJAXQSXSA-CEZRHVESSA-N Cynarin Natural products O[C@@H]1C[C@@](C[C@H](O)[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)(OC(=O)C=Cc3cccc(O)c3O)C(=O)O SITQVDJAXQSXSA-CEZRHVESSA-N 0.000 description 2
- YDDUMTOHNYZQPO-RVXRWRFUSA-N Cynarine Chemical compound O([C@@H]1C[C@@](C[C@H]([C@@H]1O)O)(OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-RVXRWRFUSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 229950009125 cynarine Drugs 0.000 description 2
- YDDUMTOHNYZQPO-BKUKFAEQSA-N cynarine Natural products O[C@H]1C[C@@](C[C@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)(OC(=O)C=Cc3ccc(O)c(O)c3)C(=O)O YDDUMTOHNYZQPO-BKUKFAEQSA-N 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 206010019668 Hepatic fibrosis Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010001584 alcohol abuse Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 208000025746 alcohol use disease Diseases 0.000 description 1
- 206010056977 alcoholic pancreatitis Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a liver-protecting pill and a preparation method thereof, wherein the liver-protecting pill is prepared from the following raw materials in parts by weight: kudzu root: 30-40 parts; green tea: 15-20 parts of a solvent; litchi pulp: 8-10 parts; and (3) mulberry fruit: 5-10 parts; dandelion: 3-5 parts; chinese yam: 1-3 parts; medlar: 1-3 parts; artichoke extract: 5-10 parts. The liver protection pill has multiple health care effects of protecting liver, coordinating intestines and stomach and the like, has no side effect, and has good taste.
Description
Technical Field
The invention relates to the technical field of health products, and particularly relates to a liver-protecting pill and a preparation method thereof.
Background
The liver is an important organ of the human digestive system, and performs important physiological functions such as metabolism/detoxification and blood homeostasis/bile excretion. The liver is the largest digestive system of the human body and is also the largest chemical plant of the human body, and all substances entering the human body are absorbed or detoxified by active enzyme of the liver. Only if the chemical plant is good, a plurality of active enzymes in the liver can normally work, and various toxins entering the body can be removed, so that various qualified nutrient substances can be provided for the organism to maintain the normal operation of physiological functions; the five zang-organs and six fu-organs and other organs of the body can be healthy without damage.
Alcoholism is an alarming public health problem in modern society. Health risks caused by alcohol impose a significant financial burden on health care systems. Long-term alcohol consumption has been associated with the development of various medical conditions, such as alcoholic liver disease, pancreatitis and brain injury. Liver damage is the most common consequence of alcohol abuse and can progress to fatty liver, steatohepatitis, fibrosis, cirrhosis and even liver cancer.
Therefore, in order to solve the above problems, we propose a liver-protecting pill and a preparation method thereof.
Disclosure of Invention
The liver-protecting pill and the preparation method thereof provided by the invention have various health-care effects of protecting the liver, coordinating intestines and stomach and the like, have no side effect and have good mouthfeel.
In order to achieve the purpose, the invention provides the following technical scheme that the liver-protecting pill is prepared from the following raw materials in parts by weight: kudzu root: 30-40 parts; green tea: 15-20 parts of a solvent; litchi pulp: 8-10 parts; and (3) mulberry fruit: 5-10 parts; dandelion: 3-5 parts; chinese yam: 1-3 parts; medlar: 1-3 parts; artichoke extract: 5-10 parts.
The artichoke extract is prepared by the following method: (1) adding globe artichoke into a stainless steel reaction kettle, adding water, performing hot reflux at 85-95 deg.C, extracting for 3 times, filtering the obtained extractive solution with 0.45 μm filter membrane to remove impurities, and collecting extractive solution; (2) concentrating the extractive solution, adding ethanol solution to obtain 50% ethanol solution, cooling, precipitating with ethanol for 12-24 hr, filtering the supernatant with 0.45 μm filter membrane to remove impurities, and collecting filtrate; (3) adsorbing the collected filtrate by a resin column, eluting by ethanol aqueous solutions with different concentrations through the adsorbed resin column respectively, filtering impurities from the eluted ethanol washing solution by a 0.22 mu m microporous filter, concentrating under vacuum at 55 ℃ to obtain a concentrated solution, spray drying the concentrated solution, grinding, and sieving by a 500-mesh sieve to obtain the artichoke extract.
A preparation method of a liver-protecting pill comprises the following specific steps: (1) cleaning and airing raw materials of kudzuvine root, green tea, litchi pulp, mulberry, dandelion, Chinese yam and medlar, and respectively placing the raw materials in a grinding machine to grind the raw materials to 400 meshes and 500 meshes; (2) putting the material obtained in the step (1) and the artichoke extract into a stirrer, and uniformly stirring and mixing; (3) boiling honey, boiling the honey with strong fire, filtering to remove foam, and slowly boiling with slow fire; (4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, and continuously and fully stirring until the honey is uniformly mixed; (5) putting the mixture obtained in the step (4) into a mould, pressing into a cake shape, and rubbing into liver-protecting pills; (6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
The weight of the honey is 1-1.5 times of the total weight of the raw materials.
In the step (2), the stirring time is 30-40min, and the rotating speed is 300-; the stirring time in the step (4) is 50-60min, and the rotating speed is 400-600 r/min.
The diameter of the finished liver-protecting pill in the step (5) is 0.5-1 cm.
Compared with the prior art, the invention has the following advantages:
1. the litchi pulp is rich in phenolic compounds, has liver protecting effect on liver injury caused by alcohol, and can be used for preventing and controlling alcoholic liver disease by taking litchi pulp in a proper amount.
2. Green tea has the highest polyphenol content in all tea leaves, and green tea polyphenol also has the liver protection effect in vivo.
3. The mulberry has certain effects on preventing and treating hepatic fibrosis and even reversing liver cirrhosis.
4. Radix Puerariae has effects of clearing heat and detoxicating, relieving hangover, lowering blood sugar, promoting metabolism, enhancing liver detoxicating function, nourishing liver, and protecting liver.
5. The artichoke extract is rich in various functional components such as cynarin, inulin and chlorogenic acid, particularly the cynarin substances are taken as the core functional components, so that the artichoke extract has good effects of protecting the liver, reducing blood fat and the like.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The artichoke extracts used in examples 1 to 5 according to the invention were prepared by the following method: (1) adding globe artichoke into a stainless steel reaction kettle, adding water, refluxing at 95 deg.C, extracting for 3 times, filtering the extractive solution with 0.45 μm filter membrane to remove impurities, and collecting extractive solution; (2) concentrating the extractive solution, adding ethanol solution to obtain 50% ethanol solution, cooling, precipitating with ethanol for 24 hr, filtering the supernatant with 0.45 μm filter membrane to remove impurities, and collecting filtrate; (3) adsorbing the collected filtrate by a resin column, eluting by ethanol aqueous solutions with different concentrations through the adsorbed resin column respectively, filtering impurities from the eluted ethanol washing solution by a 0.22 mu m microporous filter, concentrating under vacuum at 55 ℃ to obtain a concentrated solution, spray drying the concentrated solution, and grinding the concentrated solution through a 500-mesh sieve to obtain the artichoke extract.
Example 1:
preparing a liver protection pill:
(1) cleaning and airing 30 parts of kudzu root, 20 parts of green tea, 8 parts of litchi pulp, 6 parts of mulberry, 5 parts of dandelion, 2 parts of Chinese yam and 2 parts of medlar, and respectively putting the cleaned and aired raw materials into a grinder to grind the raw materials to 400 meshes and 500 meshes;
(2) putting the material obtained in the step (1) and 8 parts of artichoke extract into a stirrer with the rotating speed of 400r/min, stirring for 30min, and uniformly mixing;
(3) boiling 100 parts of honey, boiling the honey by using a big fire, filtering to remove foam, and slowly boiling the honey by using a slow fire;
(4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, setting the rotating speed at 600r/min, and continuously and fully stirring for 60min until the honey is uniformly mixed;
(5) placing the mixture obtained in the step (4) in a mould, pressing into a cake shape, and rubbing into liver-protecting pills with the diameter of 0.5-1 cm;
(6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
Example 2:
preparing a liver protection pill:
(1) cleaning and airing 35 parts of kudzu root, 18 parts of green tea, 8 parts of litchi pulp, 7 parts of mulberry, 3 parts of dandelion, 1 part of Chinese yam and 2 parts of medlar, and respectively putting the cleaned and aired raw materials into a grinder to grind the raw materials to 400 meshes and 500 meshes;
(2) putting the material obtained in the step (1) and 7 parts of artichoke extract into a stirrer with the rotating speed of 400r/min, stirring for 30min, and uniformly mixing;
(3) boiling 100 parts of honey, boiling the honey by using a big fire, filtering to remove foam, and slowly boiling the honey by using a slow fire;
(4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, setting the rotating speed at 600r/min, and continuously and fully stirring for 60min until the honey is uniformly mixed;
(5) placing the mixture obtained in the step (4) in a mould, pressing into a cake shape, and rubbing into liver-protecting pills with the diameter of 0.5-1 cm;
(6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
Example 3:
preparing a liver protection pill:
(1) cleaning and airing 40 parts of kudzu root, 15 parts of green tea, 9 parts of litchi pulp, 5 parts of mulberry, 3 parts of dandelion, 1 part of Chinese yam and 1 part of medlar, and respectively putting the cleaned and aired raw materials into a grinder to grind the raw materials to 400 meshes and 500 meshes;
(2) putting the material obtained in the step (1) and 7 parts of artichoke extract into a stirrer with the rotating speed of 400r/min, stirring for 30min, and uniformly mixing;
(3) boiling 100 parts of honey, boiling the honey by using a big fire, filtering to remove foam, and slowly boiling the honey by using a slow fire;
(4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, setting the rotating speed at 600r/min, and continuously and fully stirring for 60min until the honey is uniformly mixed;
(5) placing the mixture obtained in the step (4) in a mould, pressing into a cake shape, and rubbing into liver-protecting pills with the diameter of 0.5-1 cm;
(6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
Example 4:
preparing a liver protection pill:
(1) cleaning and airing 36 parts of kudzu root, 16 parts of green tea, 10 parts of litchi pulp, 8 parts of mulberry, 3 parts of dandelion, 2 parts of Chinese yam and 1 part of medlar, and respectively putting the cleaned and aired raw materials into a grinder to grind the raw materials to 400 meshes and 500 meshes;
(2) putting the material obtained in the step (1) and 5 parts of artichoke extract into a stirrer with the rotating speed of 400r/min, stirring for 30min, and uniformly mixing;
(3) boiling 100 parts of honey, boiling the honey by using a big fire, filtering to remove foam, and slowly boiling the honey by using a slow fire;
(4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, setting the rotating speed at 600r/min, and continuously and fully stirring for 60min until the honey is uniformly mixed;
(5) placing the mixture obtained in the step (4) in a mould, pressing into a cake shape, and rubbing into liver-protecting pills with the diameter of 0.5-1 cm;
(6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
Example 5:
preparing a liver protection pill:
(1) cleaning and airing 30 parts of kudzu root, 17 parts of green tea, 9 parts of litchi pulp, 10 parts of mulberry, 4 parts of dandelion, 2 parts of Chinese yam and 3 parts of medlar, and respectively putting the cleaned and aired raw materials into a grinder to grind the raw materials to 400 meshes and 500 meshes;
(2) putting the material obtained in the step (1) and 6 parts of artichoke extract into a stirrer with the rotating speed of 400r/min, stirring for 30min, and uniformly mixing;
(3) boiling 100 parts of honey, boiling the honey by using a big fire, filtering to remove foam, and slowly boiling the honey by using a slow fire;
(4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, setting the rotating speed at 600r/min, and continuously and fully stirring for 60min until the honey is uniformly mixed;
(5) placing the mixture obtained in the step (4) in a mould, pressing into a cake shape, and rubbing into liver-protecting pills with the diameter of 0.5-1 cm;
(6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A liver-protecting pill is characterized in that: the liver-protecting pill is prepared from the following raw materials in parts by weight: kudzu root: 30-40 parts; green tea: 15-20 parts of a solvent; litchi pulp: 8-10 parts; and (3) mulberry fruit: 5-10 parts; dandelion: 3-5 parts; chinese yam: 1-3 parts; medlar: 1-3 parts; artichoke extract: 5-10 parts.
2. The liver-protecting pill according to claim 1, characterized in that: the artichoke extract is prepared by the following method: (1) adding globe artichoke into a stainless steel reaction kettle, adding water, performing hot reflux at 85-95 deg.C, extracting for 3 times, filtering the obtained extractive solution with 0.45 μm filter membrane to remove impurities, and collecting extractive solution; (2) concentrating the extractive solution, adding ethanol solution to obtain 50% ethanol solution, cooling, precipitating with ethanol for 12-24 hr, filtering the supernatant with 0.45 μm filter membrane to remove impurities, and collecting filtrate; (3) adsorbing the collected filtrate by a resin column, eluting by ethanol aqueous solutions with different concentrations through the adsorbed resin column respectively, filtering impurities from the eluted ethanol washing solution by a 0.22 mu m microporous filter, concentrating under vacuum at 55 ℃ to obtain a concentrated solution, spray drying the concentrated solution, grinding, and sieving by a 500-mesh sieve to obtain the artichoke extract.
3. The preparation method of the liver-protecting pill according to any one of claims 1-2, which is characterized by comprising the following specific steps: (1) cleaning and airing raw materials of kudzuvine root, green tea, litchi pulp, mulberry, dandelion, Chinese yam and medlar, and respectively placing the raw materials in a grinding machine to grind the raw materials to 400 meshes and 500 meshes; (2) putting the material obtained in the step (1) and the artichoke extract into a stirrer, and uniformly stirring and mixing; (3) boiling honey, boiling the honey with strong fire, filtering to remove foam, and slowly boiling with slow fire; (4) adding the honey boiled in the step (3) into the uniform mixed material obtained in the step (2) while the honey is hot, and continuously and fully stirring until the honey is uniformly mixed; (5) putting the mixture obtained in the step (4) into a mould, pressing into a cake shape, and rubbing into liver-protecting pills; (6) and (5) packaging the liver-protecting pills obtained in the step (5) by using glass paper and wax shells.
4. The preparation method of the liver-protecting pill according to claim 3, characterized in that: the weight of the honey is 1-1.5 times of the total weight of the raw materials.
5. The preparation method of the liver-protecting pill according to claim 3, characterized in that: in the step (2), the stirring time is 30-40min, and the rotating speed is 300-; the stirring time in the step (4) is 50-60min, and the rotating speed is 400-600 r/min.
6. The preparation method of the liver-protecting pill according to claim 3, characterized in that: the diameter of the finished liver-protecting pill in the step (5) is 0.5-1 cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911170856.2A CN111000219A (en) | 2019-11-26 | 2019-11-26 | Liver-protecting pill and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911170856.2A CN111000219A (en) | 2019-11-26 | 2019-11-26 | Liver-protecting pill and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111000219A true CN111000219A (en) | 2020-04-14 |
Family
ID=70113146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911170856.2A Pending CN111000219A (en) | 2019-11-26 | 2019-11-26 | Liver-protecting pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111000219A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103589564A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicinal health care wine prepared by compounding and fermenting dandelion, Chinese yam, mulberry, medlar and gynostemma |
| CN106754212A (en) * | 2016-11-30 | 2017-05-31 | 广西大学 | A kind of relieving alcoholism and protecting liver litchi fruit vinegar beverage and preparation method thereof |
| CN107788177A (en) * | 2017-11-27 | 2018-03-13 | 爱可道生物科技有限公司 | A kind of globe artichoke compound health instant tea |
| CN108143974A (en) * | 2018-02-11 | 2018-06-12 | 钟莉华 | Relieving alcoholism and protecting liver ball |
| CN109480238A (en) * | 2018-10-26 | 2019-03-19 | 洛阳采方医药科技有限公司 | A kind of food with liver protecting |
-
2019
- 2019-11-26 CN CN201911170856.2A patent/CN111000219A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103589564A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicinal health care wine prepared by compounding and fermenting dandelion, Chinese yam, mulberry, medlar and gynostemma |
| CN106754212A (en) * | 2016-11-30 | 2017-05-31 | 广西大学 | A kind of relieving alcoholism and protecting liver litchi fruit vinegar beverage and preparation method thereof |
| CN107788177A (en) * | 2017-11-27 | 2018-03-13 | 爱可道生物科技有限公司 | A kind of globe artichoke compound health instant tea |
| CN108143974A (en) * | 2018-02-11 | 2018-06-12 | 钟莉华 | Relieving alcoholism and protecting liver ball |
| CN109480238A (en) * | 2018-10-26 | 2019-03-19 | 洛阳采方医药科技有限公司 | A kind of food with liver protecting |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104312895B (en) | Fagopyrum tararicum vinegar and making method thereof | |
| CN105767397A (en) | Spleen-invigorating and stomach-harmonizing gingko tea | |
| CN102940072A (en) | Herb tea for clearing away lung-heat and moistening liver and preparation method thereof | |
| CN104041821A (en) | Lycium ruthenicum murr anthocyanin chewable tablet | |
| CN101375715A (en) | Nutrient powder made from chickpea and grape and preparation method thereof | |
| CN103478281A (en) | Tea flavored tofu | |
| CN110214845A (en) | A method of having effects that the health preserving tea preparation for treating gout | |
| CN102994309B (en) | Ginkgo-sorghum liquor and ginkgo-sorghum health-care liquor | |
| CN110637890A (en) | Preparation method of mulberry leaf juice bean curd | |
| CN102551061B (en) | Canarium album granule with hypolipidemic and hypoglycemic effects and preparation process of same | |
| CN104286269B (en) | A kind of Qingqian Willow leaf bealth-care instant tea and preparation method thereof | |
| CN109527143A (en) | One kind ten thousand answers tea composition and preparation method thereof | |
| CN107141218A (en) | A kind of method that chlorogenic acid and gallic acid are produced from coffee bean | |
| CN111000219A (en) | Liver-protecting pill and preparation method thereof | |
| CN107083272A (en) | A kind of extracting method of granada seed oil | |
| KR101315005B1 (en) | Method for manufacturing grain syrup using ginkgo leaves | |
| CN106860489A (en) | A kind of extracting method of myrica rubra leaf polyphenol | |
| CN107541403A (en) | A kind of yellow peach fruit wine and production method | |
| CN108079219A (en) | A kind of topical composition for treating burn and scald and preparation method thereof | |
| CN106922903A (en) | A kind of vigor beauty treatment fire-toxin releasing herb tea | |
| CN110652547A (en) | Body-strengthening and lipid-lowering tea and preparation method thereof | |
| CN106880652A (en) | A kind of extracting method of mango leaf polyphenol | |
| CN111543529A (en) | Processing method of cyclocarya paliurus tea | |
| CN108208076A (en) | A kind of chocolate souffles and preparation method thereof | |
| CN109294852A (en) | A kind of tealeaves dinner party with singsong girls in attendance and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200414 |