CN108079219A - A kind of topical composition for treating burn and scald and preparation method thereof - Google Patents
A kind of topical composition for treating burn and scald and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of topical composition for treating burn and scald and preparation method thereof.Said composition is made of the 9 taste bulk pharmaceutical chemicals such as granatum, pyrrosia lingua, geranium wilfordii, wheat, Selaginella tamariscina, phoenix-tail fern, Chinese mahonia, calculus bovis factitius, radix scutellariae.Advantages of the present invention is suitable in selected bulk pharmaceutical chemicals compatibility, meets traditional Chinese medicine and pharmacy and modern medical theory, and strong with heat-clearing toxin expelling, anti-inflammatory analgetic, removing necrosis, promoting granulation, anti-infective dynamics, promotes wound healing fast, preventing from scar after healing, and therapeutic effect is notable.
Description
Technical field
The present invention relates to a kind of composition, more particularly to a kind of topical composition for treating burn and scald and its preparation side
Method.
Background technology
Burn and scald is common unexpected injury in life, and boiling water, rolling congee, deep fat, the burning of heat steam is scalded can often occur
Thing.For deep lesions, since skin person is bad than more serious, the scars such as incrustation are always left after treatment, not only influence the wounded day
Also there are many new diseases because the incrustation toxin such as position pore-free, sweat can not be discharged at the position in appearance afterwards.It is existing
The drug and method of burn and scald are treated, many incrustations can be usually formed, influence the image of the wounded, spiritual wound can be left to the wounded
Evil.To these burn and scalds, if processing is not in time, undesirable consequence would not be caused.Although burn-scald medicine currently on the market
Species is various, but generally existing cannot relieve pain rapidly, cure low, the course for the treatment of is long, it is inconvenient to use, leave apparent scar etc. more afterwards
Problem.
The content of the invention
Treatment burn and scald can be relieved pain rapidly the technical problem to be solved by the present invention is to provide one kind, cure rate is high, the course for the treatment of
It is short, easy to use, to once or two degree of burn and scalds more after do not leave the topical composition of scar.
The object of the present invention is to provide a kind of topical compositions for treating burn and scald.
Another object of the present invention is to provide a kind of preparation method for the topical composition for treating burn and scald.
The present invention is achieved through the following technical solutions：
The bulk pharmaceutical chemicals of the present composition form：
Granatum 50-150 parts by weight pyrrosia lingua 40-120 parts by weight geranium wilfordii 40-120 parts by weight
Wheat 50-150 parts by weight Selaginella tamariscina 40-120 parts by weight phoenix-tail fern 15-45 parts by weight
Chinese mahonia 15-45 parts by weight calculus bovis factitius 5-15 parts by weight radix scutellariae 5-15 parts by weight.
The bulk pharmaceutical chemicals of the present composition form：
Granatum 80-120 parts by weight pyrrosia lingua 64-96 parts by weight geranium wilfordii 64-96 parts by weight
Wheat 80-120 parts by weight Selaginella tamariscina 64-96 parts by weight phoenix-tail fern 24-36 parts by weight
Chinese mahonia 24-36 parts by weight calculus bovis factitius 8-12 parts by weight radix scutellariae 8-12 parts by weight.
The bulk pharmaceutical chemicals of the present composition form：
100 parts by weight pyrrosia lingua of granatum, 80 parts by weight geranium wilfordii, 80 parts by weight
100 parts by weight Selaginella tamariscina of wheat, 80 parts by weight phoenix-tail fern, 30 parts by weight
30 parts by weight calculus bovis factitius of Chinese mahonia, 10 parts by weight radix scutellariae, 10 parts by weight.
The bulk pharmaceutical chemicals of the present composition form：
60 parts by weight pyrrosia lingua of granatum, 110 parts by weight geranium wilfordii, 50 parts by weight
140 parts by weight Selaginella tamariscina of wheat, 50 parts by weight phoenix-tail fern, 40 parts by weight
20 parts by weight calculus bovis factitius of Chinese mahonia, 13 parts by weight radix scutellariae, 7 parts by weight.
The bulk pharmaceutical chemicals of the present composition form：
140 parts by weight pyrrosia lingua of granatum, 50 parts by weight geranium wilfordii, 110 parts by weight
60 parts by weight Selaginella tamariscina of wheat, 110 parts by weight phoenix-tail fern, 20 parts by weight
40 parts by weight calculus bovis factitius of Chinese mahonia, 7 parts by weight radix scutellariae, 13 parts by weight.
The preparation method of the present composition is：1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultra micro are taken respectively
Micropowders are crushed to obtain, more than 85% grain size of micropowder is no more than 8 microns after ultramicro grinding；The granatum of remainder 1/2 is washed
Only, the 6-10 times of water measured is added to impregnate 15-45 minutes, is then decocted, when decoction 1-3 is small for the first time, is filtered to get filtrate；The dregs of a decoction
Again with 2-6 times of water measured decoct 1-2 it is small when, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges, 3000rpm
Centrifugation centrifuges 2-6 minutes, separates supernatant, obtains supernatant A；The geranium wilfordii of remainder 1/2 is impregnated into 15- with the 4-12 times of water measured
It 45 minutes, is then decocted, when decoction 1.5-4.5 is small for the first time, filtering obtains filtrate, and the dregs of a decoction are decocted again with the 3-9 times of water measured
It when 1-3 is small, filtering to get filtrate, merges filtrate twice, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 70-90 DEG C and surveys relative density,
Add ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By remaining 1/2 wheat Ultramicro-powder
20-60 mesh is broken to, Ultramicro-powder is placed on CO2When immersion 1.5-4.5 is small in extraction kettle, it is 20- to control pressure in extraction kettle
30MPa；Ultramicro-powder after immersion is separated in separating still, it is 3-9MPa to control separating pressure value in separating still, is heated
To 20-60 DEG C, when keeping 2.5-7.5 small, CO2Flow maintain 20-40Kg/h；Extract C is obtained after separation；By pyrrosia lingua plus 4-
The water of 12 times of amounts impregnates 15-45 minutes, adds in the complex enzyme of 15-45 parts by weight, and the complex enzyme is 1:2 pectase and fiber
Plain enzyme first carries out the 20-60 DEG C of enzymolysis of 15-45 minutes, is then decocted, and when decoction 1-3 is small for the first time, filters to get filtrate；
The dregs of a decoction again with 3-9 times of water measured decoct 1-2 it is small when, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges,
3000rpm is centrifuged, and is centrifuged 2-6 minutes, is separated supernatant, is obtained supernatant D；Selaginella tamariscina is impregnated 15-45 points with the 4-12 times of water measured
Clock, adds in the complex enzyme of 6-18 parts by weight, and the complex enzyme is 3:1 neutral proteinase and pectase first carries out 20-60 DEG C
The enzymolysis of 15-45 minutes, is then decocted, and when decoction 1.5-4.5 is small for the first time, filtering obtains filtrate, the dregs of a decoction are again with 3-9 times
It when the water decoction 1-3 of amount is small, filters to get filtrate, merges filtrate twice, filtration, filtrate is concentrated into 70-90 DEG C of survey relative density and is
1.15-1.18 adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；By phoenix-tail fern, ten greatly
Contribution, calculus bovis factitius and radix scutellariae add 4-12 times to measure water to impregnate 15-45 minute, then decoct twice, when each 0.5-1.5 is small, conjunction
And decocting liquid, filtration obtain filtrate F twice；Supernatant A, supernatant B, extract C, supernatant D, supernatant E and filtrate F are mixed
It stirs evenly, adds granatum, geranium wilfordii and wheat micropowders and remix and stir evenly, add 2：1 sodium benzoate
It is mixed evenly with stearic acid 10-30 parts by weight, externally-applied soft ointment is made.
The preparation method of the present composition is：1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultra micro are taken respectively
Micropowders are crushed to obtain, more than 85% grain size of micropowder is no more than 8 microns after ultramicro grinding；The granatum of remainder 1/2 is washed
Only, the water of 8 times of amounts is added to impregnate 30 minutes, is then decocted, when decoction 2 is small for the first time, is filtered to get filtrate；The dregs of a decoction are again with 4 times
When the water decoction 1.5 of amount is small, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm is centrifuged, centrifugation
4 minutes, supernatant is separated, obtains supernatant A；The geranium wilfordii of remainder 1/2 water of 8 times of amounts is impregnated 30 minutes, is then decocted
It boils, when decoction 3 is small for the first time, filtering obtains filtrate, when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, merge twice
Filtrate, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 80 DEG C and surveys relative density, adds ethyl alcohol that alcohol content is made to stand, take up to 65%
Clear liquid recycles ethyl alcohol, obtains supernatant B；By remaining 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2Extraction kettle
It is middle impregnate 3 it is small when, it is 25MPa control in extraction kettle pressure；Ultramicro-powder after immersion is separated in separating still, control point
It is 6MPa from separating pressure value in kettle, is heated up to 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；It must be carried after separation
Take object C；The water that pyrrosia lingua plus 8 times are measured is impregnated 30 minutes, adds in the complex enzyme of 30 parts by weight, the complex enzyme is 1:2 pectin
Enzyme and cellulase first carry out 40 DEG C of enzymolysis of 30 minutes, are then decocted, and when decoction 2 is small for the first time, filter to get filtrate；
When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges,
3000rpm is centrifuged, and is centrifuged 4 minutes, is separated supernatant, is obtained supernatant D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in 12
The complex enzyme of parts by weight, the complex enzyme are 3:1 neutral proteinase and pectase first carries out 40 DEG C of enzymolysis of 30 minutes, so
After decocted, decoct for the first time 3 it is small when, filtering obtains filtrate, when the dregs of a decoction are small with the water decoctions 2 of 6 times of amounts again, filters to get filtrate,
Merge filtrate twice, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 80 DEG C and surveys relative density, and ethyl alcohol is added to make alcohol content up to 65%, quiet
It puts, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；8 times of amount water is added to impregnate 30 phoenix-tail fern, Chinese mahonia, calculus bovis factitius and radix scutellariae
Minute, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filtration obtains filtrate F；By supernatant A, supernatant B, extraction
Object C, supernatant D, supernatant E and filtrate F are mixed evenly, and add granatum, geranium wilfordii and wheat micropowders and mix again
Conjunction stirs evenly, and adds 2：1 sodium benzoate and 20 parts by weight of stearic acid is mixed evenly, and externally-applied soft ointment is made.
The present composition according to common process add in customary adjuvant be made the externally-applied soft ointment of clinical receiving, emplastrum,
Spray, liniment, drops or tincture.
Bulk pharmaceutical chemicals in the present composition carry out compatibility, wherein granatum, pyrrosia lingua, geranium wilfordii, wheat by monarch
It is monarch drug in a prescription with 5 taste bulk pharmaceutical chemicals of Selaginella tamariscina, main therapeutic effect, another phoenix-tail fern and ten big work(is played in the present invention treats burn and scald
2 taste bulk pharmaceutical chemicals of labor are ministerial drug, and monarch drug in a prescription is aided in strengthen the adjuvant for the treatment of burn and scald, other calculus bovis factitiuses and radix scutellariae 2 in the present invention
Taste bulk pharmaceutical chemicals is adjutants and make medicine, play the role of accompanying symptoms in the compositions of the present invention.The core of the present composition is raw material
Proportion relation between medicine, identical bulk pharmaceutical chemicals carry out different distribution and proportioning in the composition, and generated effect is also
It is completely different.Chinese medicine composition it is most exquisite be each bulk pharmaceutical chemicals proportioning synergistic effect, some bulk pharmaceutical chemicals combinations can interpromoting relation in five elements,
Some bulk pharmaceutical chemicals combination meeting restrictions or checking relations in five elements, the combination of different bulk pharmaceutical chemicals, different proportionings can bring different therapeutic effects, and have
Toxic side effect can also be brought.
Inventor has found in screening process, only by 1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat Ultramicro-powder
It is broken to obtain micropowders, centrifuge to obtain supernatant A after the granatum decoction of remainder 1/2；The geranium wilfordii of remaining 1/2 amount uses ethyl alcohol after decocting
Extract supernatant B, remaining 1/2 amount wheat crushing after separate to obtain extract C, pyrrosia lingua and Selaginella tamariscina are carried out respectively with complex enzyme
Extraction, remaining 4 taste medicines carry out decoction form and are used as medicine again, obtained yield highest, and it is best to be made the effect of ointment, will not be mutual
Destroy effective ingredient so that effective ingredient is more stable.If be used as medicine less than above-mentioned raw materials fine powder form, yield improves unobvious,
It is used as medicine higher than above-mentioned content of starting materials fine powder, manufactured ointment cannot reach defined specification, and preparation effect is bad.Simultaneously will
Bulk pharmaceutical chemicals merge decoction together, can mutually destroy effective ingredient so that effective ingredient is unstable, and yield is low.
Using Chinese medical extract as the externally-applied soft ointment of chief component, due to more than extract component and complicated oneself viscosity
Higher, general externally-applied soft ointment absorption is slower, influences its treatment results.Therefore, the present invention is with the addition of 2：1 sodium benzoate and
After externally-applied soft ointment made by stearic acid, it just can be good at discharging drug after 10 minutes, reach optimal therapeutic effect.
1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat are used into ultra micro in the preparation method of the present composition
It crushes, grain size of micropowder is small, since ultramicro grinding process materials temperature is less than -18 DEG C；Chinese medicine Ultramicro-powder after ultramicro grinding,
Pollution-free, the peeling of the heavy metals break flour such as Chrome-free, nickel, cadmium, titanium, iron, copper, zinc, lead, arsenic particle disengages.By the pomegranate of remainder 1/2
Skin, 1/2 geranium wilfordii and 1/2 wheat are extracted respectively so that its active ingredient is not destroyed, extract drug it is effective into
Part is more complete, dissolution rate height, drug effect retention time length and bioavilability height of drug etc..Pyrrosia lingua and volume are separately used into complex enzyme in vain
Extract so that the extraction of its active ingredient more completely, content higher, stability it is more preferable, this method has carried out extract pure
Change, curative effect, there has also been significantly improving, is also greatly reduced production cost with traditional technics comparing；The improved technique of the present invention is also
It is with the addition of appropriate amount of auxiliary materials, adds made ointment after auxiliary material and absorb very fast, just can be good at discharging medicine after 10 minutes
Object reaches optimal therapeutic effect.
Application of the continuous someone's studying enzyme in traditional Chinese medicine extraction in recent years, and achieve good effect.The present invention adopts
The advanced technology is optimized and improves to traditional decoction technique according to the property feature of raw material pharmaceutically active ingredient.For enzyme
Lot of experiments has been done in the selection of species and dosage.Finally obtain ointment made from above-mentioned preparation method and the method.The party
Method purifies extract, and in the case where reducing a large amount of impurity, obtained extract improves significantly than conventional method,
And active ingredient also stablize by more former traditional handicraft, curative effect is more also significantly increased with traditional handicraft, is also greatly reduced life
Produce cost.Different bulk pharmaceutical chemicals, the enzyme and dosage being applicable in are not quite similar.The effect digested when the dosage of enzyme is relatively low is poor,
It raises with the concentration of enzyme, increases with the contact area of substrate, the increase of enzyme digestion reaction rate, but it is not the higher the better, when enzyme reaches
To can then generate inhibitory action during a certain concentration, enzyme is not fully utilized, and causes to waste.Therefore, inventor is to the species of enzyme
And dosage is investigated, it is found that difference on effect is apparent.Wherein with 1:The multiplex-enzyme extraction of 2 pectase and cellulase combination
The best results of pyrrosia lingua, with 3:The best results of the multiplex-enzyme extraction Selaginella tamariscina of 1 neutral proteinase and pectase combination, make pyrrosia lingua
With the extraction of the active ingredient of Selaginella tamariscina more completely, content higher, stability it is more preferable, this method purifies extract, curative effect
With tradition technics comparing, there has also been significantly improve.
It is an advantage of the current invention that bulk pharmaceutical chemicals compatibility is suitable selected by this external used medicine, meet traditional Chinese medicine and pharmacy and modern medicine
Theory, and it is strong with heat-clearing toxin expelling, anti-inflammatory analgetic, removing necrosis, promoting granulation, anti-infective dynamics, promote wound healing fast, after healing not
Scar is stayed, therapeutic effect is notable.The present invention is by carrying out optimal distribution and proportioning to each bulk pharmaceutical chemicals so that each bulk pharmaceutical chemicals exist
Reach optimal therapeutic effect in the present invention, and mutually auxiliary phase assistant can be played the role of simultaneously.
Granatum is the drying pericarp of Punicaceae plant pomegranate Punica granatum L. in the present composition.China
There is cultivation in north and south, more with Jiangsu, Henan and other places.With relieving diarrhea with astringents, the effect of hemostasis, expelling parasite.It is usually used in chronic diarrhea, long
Dysentery is had blood in stool, rectal prolapse, uterine bleeding, under band, abdominal pain due to enterositosis.Pyrrosia lingua (Latin literary fame:Pyrrosia lingua(Thunb.)
Farwell) the medium-sized pteridophyte that grows nonparasitically upon another plant of Polypodiaceaes, Genus Pyrrosia, plant is up to 30 centimetres.Pyrrosia lingua, nature and flavor are sweet, bitter, micro-
It is cold.Enter lung, bladder warp.There is the effects that promoting diuresis for stranguria, clearing lung-heat expel the heat-evil.Energy clearing away damp-heat, inducing diuresis for treating strangurtia control knife wound, scald, de- power void
Damage.Geranium wilfordii (scientific name：Geranium wilfordii Maxim.) it the old stork mouth of alias, crow mouth, passes through muscle, pass through muscle, old ox always
Muscle.It is born in hillside, meadow, ridge, roadside and village premises.The major function of geranium wilfordii is exactly to treat rheumatism, promoting blood circulation
Arteries and veins, network of promoting blood circulation, usually applied to symptoms such as rheumatalgia pain, rheumatism paralysis, extremity numbness, traumatic injuries.Wheat is that wheat system plants
The general designation of object is monocotyledon, is a kind of grass planted extensively all over the world, the caryopsis of wheat is the mankind
One of staple food can make the foods such as bread, steamed bun, biscuit, noodles after wearing into flour；It can be made into beer, alcohol, white wine after fermentation
(such as vodka) or raw matter fuel.Wheat is rich in starch, protein, fat, minerals, calcium, iron, thiamine, riboflavin, cigarette
Acid, vitamin A and vitamin C etc..Wheat is cured mainly except visitor's heat, is stopped polydipsia and is swallowed dry, diuresis, nourishing the liver gas, leak-stopping blood spitting blood.Volume
Cypress, Chinese medicine name.For Spikemoss plant Selaginella tamariscina Selaginella tamariscina (Beauv.) Spring or Selaginella pulvinata
The drying herb of Selaginella pulvinata (Hook.et Grev.) Maxim..Whole year can harvest, remove fibrous root and
Silt dries.It is distributed in national most area.There is invigorate blood circulation.For closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen is fallen and is flutterred
Damage.Selaginella tamariscina charcoal has the effect of removing blood stasis and hemostasis.For spitting blood, uterine bleeding is had blood in stool, rectal prolapse.Phoenix-tail fern is mainly leaf and ecological with its
Environment is named, and there are many alias, such as golden pheasant tail, halymenia dentata, Pteris multifida, are a kind of pteridophytes, belong to Pteridaceae, phoenix
Tail Cyclosorus.Scientific name Pteris multifda poir.Happiness is grown in concealment, moistening, warm place.Also it is drought-enduring, in southern winter, stone
The plant warp grown in seam-February is arid, still will not be completely withered.The main product Yangtze river basin and on the south each province, area, northern Shan
The provinces such as west, Hebei, Shandong are also distributed.It is cool in nature with all herbal medicine, mildly bitter flavor, Return liver, kidney, large intestine channel, have clearing heat and promoting diuresis,
Cooling blood and hemostasis, subdhing swelling and detoxicating and other effects, for treating dysentery, enteritis, icteric hepatitis, spitting blood, have blood in stool, the illnesss such as hematuria.Ten
Big contribution is Berberidaceae Chinese mahonia platymiscium, can do potting, Chinese garden planting and medicinal.Alias:Mahonia fortunei, spire
Ten big work(contributions, yellow nandina, indian trumpetflower bark, Ilex pernyi, wintergreen barberry root, octagonal thorn, thorn Cortex Phellodendri, cat head (Wan Nan is commonly called as, cat thorn leaf),
Yellow thorn.Leatherleaf mahonia, Chinese mahonia, mountain radix scutellariae, west wind bamboo, soulie barberry bark.It is born in hillside hayashishita and the filling of 350-2000 meters of height above sea level
At wooden clump or more dark and damp place, the moon is raw, passes through seminal propagation.It can be used as medicine, clearing heat and detoxicating, detumescence, antidiarrheal diarrhea, dysentery, jaundice liver
Scorching, burn, scald and sore.Calculus bovis factitius, Chinese medicine name.This product is red by bilein, cholic acid, hyodesoxycholic acid, taurine, courage
Element, cholesterol, trace element etc. are processed into.For yellow loose powder.With the effect of clearing heat and detoxicating, resolving sputum is calmed the frightened.It is common
Raved in phlegm heat it is mad, coma in silence, pediatric acute convulsion, abscess of throat, aphthae, the treatment of the illnesss such as carbuncle swells furunculosis.Radix scutellariae sheet
Name " a kind of reed mentioned in ancient books " is careless for a kind of reed mentioned in ancient books, has popular name " radix scutellariae " due to careless color is yellow." a kind of reed mentioned in ancient books " word literal sense is " Folium Callicarpae Formosanae ".The golden tea of alias Radix Scutellariae, soil
Root.For labiate radix scutellariae (Scutellaria baicalensis Georgi), it is used as medicine with root.There are heat-clearing and damp-drying drug, cool blood
Tocolysis, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes,
The diseases such as fetal irritability, hypertension, carbuncle swells furuncle sore.The all medicine of the present invention merges with heat-clearing toxin expelling, anti-inflammatory analgetic, removing necrosis, promoting granulation, anti-
Infection dynamics is strong, promotes wound healing fast, preventing from scar after healing, and therapeutic effect is notable.
Experimental example is for further illustrating the present invention below, but is not limited to the present invention.
The screening of experimental example one, composition proportioning
1st, the composition of drug
Granatum, pyrrosia lingua, geranium wilfordii, wheat, Selaginella tamariscina, phoenix-tail fern, Chinese mahonia, calculus bovis factitius, radix scutellariae.
2nd, the proportioning of bulk pharmaceutical chemicals
Table 1
3rd, preparation method (above-mentioned 1 prescription 1- prescriptions 7 of table are prepared by the following method)
1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultramicro grinding is taken to obtain micropowders respectively, in ultramicro grinding
More than 85% grain size of micropowder is no more than 8 microns afterwards；The granatum of remainder 1/2 is cleaned, the water of 8 times of amounts is added to impregnate 30 minutes,
Then decocted, when decoction 2 is small for the first time, filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 4 times of amounts again, filtering obtains
Filtrate merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm centrifugations centrifuge 4 minutes, separate supernatant, obtain supernatant
A；The geranium wilfordii of remainder 1/2 water of 8 times of amounts is impregnated 30 minutes, is then decocted, when decoction 3 is small for the first time, filtering obtains
Filtrate when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, merges filtrate twice, filtration, filtrate is concentrated into 80 DEG C of surveys
Relative density is 1.15-1.18, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By more than
Under 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2When immersion 3 is small in extraction kettle, pressure in extraction kettle is controlled
For 25MPa；Ultramicro-powder after immersion is separated in separating still, it is 6MPa to control separating pressure value in separating still, is heated
To 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；Extract C is obtained after separation；The water that pyrrosia lingua plus 8 times are measured is impregnated
30 minutes, the complex enzyme of 30g is added in, the complex enzyme is 1:2 pectase and cellulase first carries out 40 DEG C of enzymes of 30 minutes
Solution, is then decocted, and when decoction 2 is small for the first time, is filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering,
Filtrate is obtained, merges filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifugation 4 minutes separates supernatant, obtains supernatant
Liquid D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in the complex enzyme of 12g, the complex enzyme is 3:1 neutral proteinase and
Pectase first carries out 40 DEG C of enzymolysis of 30 minutes, is then decocted, and when decoction 3 is small for the first time, filtering obtains filtrate, the dregs of a decoction are again
With the water of 6 times of amounts decoct 2 it is small when, filter to get filtrate, merge filtrate twice, filtration, filtrate, which is concentrated into 80 DEG C, surveys relative densities and be
1.15-1.18 adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；By phoenix-tail fern, ten greatly
Contribution, calculus bovis factitius and radix scutellariae add 8 times of amount water to impregnate 30 minutes, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filter
It crosses, obtains filtrate F；Supernatant A, supernatant B, extract C, supernatant D, supernatant E and filtrate F are mixed evenly, then added
Enter granatum, geranium wilfordii and wheat micropowders to remix and stir evenly, add 2：1 sodium benzoate and stearic acid 20g mixes
Conjunction stirs evenly, and externally-applied soft ointment, every 15ml is made.
4th, general information
(1) I degree, II degree of burned patient totally 280, wherein age 2-60 Sui, male 150, women 130 are selected.
7 groups are equally divided into, every group of 40 people treat burn and scald using the ointment in 1 prescription of table respectively, are applied directly to affected part, daily
Once in the morning and once at night, treat 7 days altogether.
(2) III degree and Yi Shang burned patient 140, wherein age 2-60 Sui, male 70, women 70 are selected.It is flat
7 groups are divided into, every group of 20 people treat burn and scald using the ointment in 1 prescription of table respectively, are applied directly to affected part, daily early
Evening is each once, treats 15 days altogether.
5th, diagnostic criteria
I degree (slight)；The gross area in 10% (children 5%) below；
II degree of burn, epidermis are damaged, local erythema and mild swelling, allergy of keenly feeling；The gross area is in 11%~30% (children
For 6%~15%) between, local exudation has blister, redness, pain.
III degree：The gross area is 31%~50%, and corium deep layer is damaged, light red, and there are red point, hypalgesia, healing in surface
After have scar.
IV degree：The gross area is between 51%~80% (children are 26%~40%), and skin holostrome is damaged, no blister and nothing
The pain sensation can form eschar.
6th, efficacy assessment standard
It cures：Whole body burn and scald symptom disappears, wound healing, no scar.
It improves：Constitutional symptom disappears substantially, and the open sore part does not heal completely.
It is not cured：Whole body and local symptom it is unchanged or aggravate.
7th, treatment results
2 I degree, II degree burned patient treatment results of table
3 III degree of table and Yi Shang burned patient treatment results
The proportioning screening of above-mentioned raw materials medicine can draw, I degree for the treatment of, II degree of burned patient as a result, prescription 1 to prescription
In 7, only the proportioning of prescription 1 can reach 100% in the effective percentage for the treatment of burn and scald, and the effective percentage of prescription 2 and prescription 3 can reach
To 80-83%, the effective percentage of other 4 groups of raw material proportionings can only achieve 63-68%.In III degree for the treatment of and Yi Shang burned patient
As a result as can be seen that prescription 1 is into prescription 7, only the proportioning of prescription 1 can reach 100% in the effective percentage for the treatment of burn and scald,
The effective percentage of prescription 2 and prescription 3 can reach 70-75%, and the effective percentage of other 4 groups of raw material proportionings can only achieve 55-65%.Therefore
Preferential bulk pharmaceutical chemicals proportioning prescription 1.It can be drawn by above-mentioned experiment, the proportioning of composition material medicine rises in terms of burn and scald is treated
To extremely important effect, not arbitrary proportioning has significant effect, but only specific proportioning can be only achieved treatment and burn
The remarkable result of scald.Above-mentioned prescription 1 is compared with prescription 4-7, and there were significant differences for treatment results.
Experimental example two, clinical trial
1st, general information
(1) I degree, II degree of burned patient totally 350, wherein age 2-60 Sui, male 180, women 170 are selected.
7 groups are equally divided into, every group of 50 people are treated respectively according to following therapy, are treated 7 days altogether.
(2) III degree and Yi Shang burned patient 210, wherein age 2-60 Sui, male 110, women 100 are selected.
7 groups are equally divided into, every group of 30 people are treated respectively according to following therapy, are treated 15 days altogether.
2nd, drug forms
Present invention group 1：Ointment is prepared according to 1 method of embodiment.
Present invention group 2：Ointment is prepared according to 2 method of embodiment.
Present invention group 3：Ointment is prepared according to 3 method of embodiment.
Control group 1：Number of patent application 201310538865.9 (publication number CN103610920B), according to 1 method of embodiment
It is prepared into spray.
Control group 2：Number of patent application 98112570.0 (publication number CN1242997A) is prepared into soft according to embodiment method
Paste.
Control group 3：Number of patent application 200510105232.4 (publication number CN1939441A) is prepared according to 1 method of embodiment
Into powder.
Control group 4：Number of patent application 201310583820.3 (publication number CN103599291B), according to embodiment method system
Into ointment.
3rd, therapy
Present invention group 1：Ointment, every 15g, is applied to affected part daily morning and evening, continuous treatment 7 days.
Present invention group 2：Ointment, every 15g, is applied to affected part daily morning and evening, continuous treatment 7 days.
Present invention group 3：Ointment, every 15g, is applied to affected part daily morning and evening, continuous treatment 7 days.
Control group 1：Spray twice a day, is sprayed on affected part, continuous treatment 7 days.
Control group 2：Ointment is applied to affected part daily morning and evening, continuous treatment 7 days.
Control group 3：Powder is tuned into paste with sesame oil and spreads on affected part, twice daily.Continuous treatment 7 days.
Control group 4：Ointment is applied to affected part daily morning and evening, continuous treatment 7 days.
4th, diagnostic criteria
I degree (slight)；The gross area in 10% (children 5%) below；
II degree of burn, epidermis are damaged, local erythema and mild swelling, allergy of keenly feeling；The gross area is in 11%~30% (children
For 6%~15%) between, local exudation has blister, redness, pain.
III degree：The gross area is 31%~50%, and corium deep layer is damaged, light red, and there are red point, hypalgesia, healing in surface
After have scar.
IV degree：The gross area is between 51%~80% (children are 26%~40%), and skin holostrome is damaged, no blister and nothing
The pain sensation can form eschar.
5th, efficacy assessment standard
It cures：Whole body burn and scald symptom disappears, wound healing, no scar.
It improves：Constitutional symptom disappears substantially, and the open sore part does not heal completely.
It is not cured：Whole body and local symptom it is unchanged or aggravate.
6th, treatment results are shown in Table 4 and table 5：
4 I degree, II degree burned patient treatment results of table
5 III degree of table and Yi Shang burned patient treatment results
The treatment results of above-mentioned table 4 and table 5 can show that present invention group 1 is scalded in I degree, II degree, III degree for the treatment of and above burn
It is optimal to hinder the total effective rate of patient, can reach 100%, I degree, II degree, III degree of the treatment of present invention group 2 and present invention group 3 and with
The total effective rate 73-84% of upper burned patient, other 4 groups of total effective rates are all in 70-82%.It can be obtained by above-mentioned experiment
Go out, the therapeutic effect of present invention group 1 is substantially better than other 6 groups, and there were significant differences for treatment results.
Experimental example three, bulk pharmaceutical chemicals pyrrosia lingua enzyme class and dosage screening experiment
1. bulk pharmaceutical chemicals pyrrosia lingua is in the screening experiment of selection enzyme class
Enzyme or complex enzyme (enzyme class is shown in Table 6) and the proportioning of pyrrosia lingua are：Enzyme or complex enzyme 30g, pyrrosia lingua 80g；
The water that pyrrosia lingua plus 8 times are measured impregnates 30 minutes, adds in enzyme or complex enzyme in table 6, first carries out 40 DEG C 30 minutes
Enzymolysis, is then decocted, and when decoction 2 is small for the first time, is filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, mistake
Filter obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm centrifugations centrifuge 4 minutes, separate supernatant, obtain
Supernatant；
Pyrrosia lingua is extracted according to said ratio and extracting method with 7 kinds of enzymes in table 6 or complex enzyme, is extracted between different enzymes
Yield difference is apparent, wherein with pectase+cellulase (1:2) the compound enzyme effect of cooperation is the most notable, and other kinds of
Enzyme is compared, and there were significant differences for yield raising.Refer to table 6.
The screening test result (pyrrosia lingua) of 6 enzyme class of table
| Group number | Enzyme class | Pyrrosia lingua yield g | Pyrrosia lingua yield % |
| 1 | Cellulase | 21.04 | 26.3% |
| 2 | Pectase | 21.84 | 27.3 |
| 3 | Papain | 20.24 | 25.3% |
| 4 | Neutral proteinase | 19.68 | 24.6% |
| 5 | Pectase+papain (1:2) | 25.68 | 32.1% |
| 6 | Pectase+cellulase (1:2) | 52.32 | 65.4% |
| 7 | Papain+cellulase (1:2) | 24.08 | 30.1% |
According to the screening test of 6 enzyme class of table the results show that 6 pectases of group number+cellulase (1:2) in extraction pyrrosia lingua
Yield highest, there were significant differences compared with other enzymes, therefore the preferred pectase+cellulase (1 of complex enzyme:2).
2nd, bulk pharmaceutical chemicals pyrrosia lingua is screened in the ratio of pectase and cellulase.It is shown in Table 7
The ratio screening test result of 7 pectase of table and cellulase
According to the ratio screening test of 7 pectase of table and cellulase the results show that 1 pectase of group number+cellulase (1:
2) yield that ratio is obtained when extracting pyrrosia lingua is highest, and there were significant differences compared with other ratios.Therefore pectase+fiber
The ratio of plain enzyme preferably 1:2.
3rd, bulk pharmaceutical chemicals pyrrosia lingua is screened in the dosage of pectase and cellulase.It is shown in Table 8
8 complex enzyme of table is used to extract the dosage screening test result of pyrrosia lingua
| Group number | Pyrrosia lingua dosage | Compound enzyme dosage | Pyrrosia lingua yield % |
| 1 | 80g | 20g | 40.9% |
| 2 | 80g | 30g | 65.4% |
| 3 | 80g | 40g | 38.8% |
It is drawn according to 8 result of the test of table, the yield highest that complex enzyme dosage when for extracting pyrrosia lingua is extracted in 30g.
Experimental example three, bulk pharmaceutical chemicals Selaginella tamariscina enzyme class and dosage screening experiment
1. bulk pharmaceutical chemicals Selaginella tamariscina is in the screening experiment of selection enzyme class
Enzyme or complex enzyme (enzyme class is shown in Table 9) and the proportioning of Selaginella tamariscina are：Enzyme or complex enzyme 12g, Selaginella tamariscina 80g；
The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, enzyme or complex enzyme in table 9 is added in, first carries out 40 DEG C of enzymes of 30 minutes
It solves, is then decocted, when decoction 3 is small for the first time, filtering obtains filtrate, when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filters
Filtrate merges filtrate twice, filtration, and it is 1.15-1.18 that filtrate, which is concentrated into 80 DEG C and surveys relative density, and ethyl alcohol is added to reach alcohol content
65%, it stands, supernatant is taken to recycle ethyl alcohol, obtains supernatant；
Selaginella tamariscina is extracted according to said ratio and extracting method with 7 kinds of enzymes in table 9 or complex enzyme, is extracted between different enzymes
Yield difference is apparent, wherein with neutral proteinase+pectase (3:1) the compound enzyme effect of cooperation is the most notable, with other species
Enzyme be compared, yield improve there were significant differences.Refer to table 9.
The screening test result (Selaginella tamariscina) of 9 enzyme class of table
According to the screening test of 9 enzyme class of table the results show that 6 neutral proteinases of group number+pectase (3:1) in extraction Selaginella tamariscina
Yield highest, there were significant differences compared with other enzymes, therefore the preferred neutral proteinase+pectase (3 of complex enzyme:1).
2nd, bulk pharmaceutical chemicals Selaginella tamariscina is screened in the ratio of neutral proteinase and pectase.It is shown in Table 10
The ratio screening test result of 10 neutral proteinase of table and pectase
| Group number | Complex enzyme | Selaginella tamariscina yield g | Selaginella tamariscina yield % |
| 1 | Neutral proteinase+pectase (3:1) | 53.84 | 67.3% |
| 2 | Neutral proteinase+pectase (1:1) | 29.12 | 36.4% |
| 3 | Neutral proteinase+pectase (1:3) | 28.08 | 35.1% |
| 4 | Neutral proteinase+pectase (2:1) | 32.08 | 40.1% |
| 5 | Neutral proteinase+pectase (1:2) | 29.76 | 37.2% |
According to the ratio screening test of 10 neutral proteinase of table and pectase the results show that 1 neutral proteinase of group number and fruit
Glue enzyme (3:1) yield that ratio is obtained when extracting Selaginella tamariscina is highest, and there were significant differences compared with other ratios.Therefore it is neutral
The ratio of protease and pectase preferably 3:1.
3rd, bulk pharmaceutical chemicals Selaginella tamariscina is screened in the dosage of neutral proteinase and pectase.It is shown in Table 11
11 complex enzyme of table is used to extract the dosage screening test result of Selaginella tamariscina
| Group number | Selaginella tamariscina dosage | Compound enzyme dosage | Selaginella tamariscina yield % |
| 1 | 80g | 34.32g | 42.9% |
| 2 | 80g | 53.84g | 67.3% |
| 3 | 80g | 35.84g | 44.8% |
It is drawn according to 11 result of the test of table, the yield highest that complex enzyme dosage when for extracting Selaginella tamariscina is extracted in 12g.
Following embodiments can realize the effect of above-mentioned experimental example.
Specific embodiment
1 ointment of embodiment
Granatum 100g pyrrosia lingua 80g geranium wilfordiis 80g
Wheat 100g Selaginella tamariscina 80g phoenix-tail ferns 30g
Chinese mahonia 30g calculus bovis factitius 10g radix scutellariaes 10g.
1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultramicro grinding is taken to obtain micropowders respectively, in ultramicro grinding
More than 85% grain size of micropowder is no more than 8 microns afterwards；The granatum of remainder 1/2 is cleaned, the water of 8 times of amounts is added to impregnate 30 minutes,
Then decocted, when decoction 2 is small for the first time, filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 4 times of amounts again, filtering obtains
Filtrate merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm centrifugations centrifuge 4 minutes, separate supernatant, obtain supernatant
A；The geranium wilfordii of remainder 1/2 water of 8 times of amounts is impregnated 30 minutes, is then decocted, when decoction 3 is small for the first time, filtering obtains
Filtrate when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, merges filtrate twice, filtration, filtrate is concentrated into 80 DEG C of surveys
Relative density is 1.15-1.18, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By more than
Under 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2When immersion 3 is small in extraction kettle, pressure in extraction kettle is controlled
For 25MPa；Ultramicro-powder after immersion is separated in separating still, it is 6MPa to control separating pressure value in separating still, is heated
To 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；Extract C is obtained after separation；The water that pyrrosia lingua plus 8 times are measured is impregnated
30 minutes, the complex enzyme of 30g is added in, the complex enzyme is 1:2 pectase and cellulase first carries out 40 DEG C of enzymes of 30 minutes
Solution, is then decocted, and when decoction 2 is small for the first time, is filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering,
Filtrate is obtained, merges filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifugation 4 minutes separates supernatant, obtains supernatant
Liquid D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in the complex enzyme of 12g, the complex enzyme is 3:1 neutral proteinase and
Pectase first carries out 40 DEG C of enzymolysis of 30 minutes, is then decocted, and when decoction 3 is small for the first time, filtering obtains filtrate, the dregs of a decoction are again
With the water of 6 times of amounts decoct 2 it is small when, filter to get filtrate, merge filtrate twice, filtration, filtrate, which is concentrated into 80 DEG C, surveys relative densities and be
1.15-1.18 adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；By phoenix-tail fern, ten greatly
Contribution, calculus bovis factitius and radix scutellariae add 8 times of amount water to impregnate 30 minutes, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filter
It crosses, obtains filtrate F；Supernatant A, supernatant B, extract C, supernatant D, supernatant E and filtrate F are mixed evenly, then added
Enter granatum, geranium wilfordii and wheat micropowders to remix and stir evenly, add 2：1 sodium benzoate and stearic acid 20g mixes
Conjunction stirs evenly, and externally-applied soft ointment, every 15ml is made.Affected part is applied to daily morning and evening.
2 ointment of embodiment
Granatum 60g pyrrosia lingua 110g geranium wilfordiis 50g
Wheat 140g Selaginella tamariscina 50g phoenix-tail ferns 40g
Chinese mahonia 20g calculus bovis factitius 13g radix scutellariaes 7g.
1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultramicro grinding is taken to obtain micropowders respectively, in ultramicro grinding
More than 85% grain size of micropowder is no more than 8 microns afterwards；The granatum of remainder 1/2 is cleaned, the water of 8 times of amounts is added to impregnate 30 minutes,
Then decocted, when decoction 2 is small for the first time, filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 4 times of amounts again, filtering obtains
Filtrate merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm centrifugations centrifuge 4 minutes, separate supernatant, obtain supernatant
A；The geranium wilfordii of remainder 1/2 water of 8 times of amounts is impregnated 30 minutes, is then decocted, when decoction 3 is small for the first time, filtering obtains
Filtrate when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, merges filtrate twice, filtration, filtrate is concentrated into 80 DEG C of surveys
Relative density is 1.15-1.18, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By more than
Under 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2When immersion 3 is small in extraction kettle, pressure in extraction kettle is controlled
For 25MPa；Ultramicro-powder after immersion is separated in separating still, it is 6MPa to control separating pressure value in separating still, is heated
To 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；Extract C is obtained after separation；The water that pyrrosia lingua plus 8 times are measured is impregnated
30 minutes, the complex enzyme of 30g is added in, the complex enzyme is 1:2 pectase and cellulase first carries out 40 DEG C of enzymes of 30 minutes
Solution, is then decocted, and when decoction 2 is small for the first time, is filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering,
Filtrate is obtained, merges filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifugation 4 minutes separates supernatant, obtains supernatant
Liquid D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in the complex enzyme of 12g, the complex enzyme is 3:1 neutral proteinase and
Pectase first carries out 40 DEG C of enzymolysis of 30 minutes, is then decocted, and when decoction 3 is small for the first time, filtering obtains filtrate, the dregs of a decoction are again
With the water of 6 times of amounts decoct 2 it is small when, filter to get filtrate, merge filtrate twice, filtration, filtrate, which is concentrated into 80 DEG C, surveys relative densities and be
1.15-1.18 adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；By phoenix-tail fern, ten greatly
Contribution, calculus bovis factitius and radix scutellariae add 8 times of amount water to impregnate 30 minutes, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filter
It crosses, obtains filtrate F；Supernatant A, supernatant B, extract C, supernatant D, supernatant E and filtrate F are mixed evenly, then added
Enter granatum, geranium wilfordii and wheat micropowders to remix and stir evenly, add 2：1 sodium benzoate and stearic acid 20g mixes
Conjunction stirs evenly, and externally-applied soft ointment, every 15ml is made.Affected part is applied to daily morning and evening.
3 ointment of embodiment
Granatum 140g pyrrosia lingua 50g geranium wilfordiis 110g
Wheat 60g Selaginella tamariscina 110g phoenix-tail ferns 20g
Chinese mahonia 40g calculus bovis factitius 7g radix scutellariaes 13g.
1/2 granatum, 1/2 geranium wilfordii and 1/2 wheat ultramicro grinding is taken to obtain micropowders respectively, in ultramicro grinding
More than 85% grain size of micropowder is no more than 8 microns afterwards；The granatum of remainder 1/2 is cleaned, the water of 8 times of amounts is added to impregnate 30 minutes,
Then decocted, when decoction 2 is small for the first time, filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 4 times of amounts again, filtering obtains
Filtrate merges filtrate twice, filtering, and filtrate centrifuges, and 3000rpm centrifugations centrifuge 4 minutes, separate supernatant, obtain supernatant
A；The geranium wilfordii of remainder 1/2 water of 8 times of amounts is impregnated 30 minutes, is then decocted, when decoction 3 is small for the first time, filtering obtains
Filtrate when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, merges filtrate twice, filtration, filtrate is concentrated into 80 DEG C of surveys
Relative density is 1.15-1.18, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By more than
Under 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2When immersion 3 is small in extraction kettle, pressure in extraction kettle is controlled
For 25MPa；Ultramicro-powder after immersion is separated in separating still, it is 6MPa to control separating pressure value in separating still, is heated
To 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；Extract C is obtained after separation；The water that pyrrosia lingua plus 8 times are measured is impregnated
30 minutes, the complex enzyme of 30g is added in, the complex enzyme is 1:2 pectase and cellulase first carries out 40 DEG C of enzymes of 30 minutes
Solution, is then decocted, and when decoction 2 is small for the first time, is filtered to get filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering,
Filtrate is obtained, merges filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, centrifugation 4 minutes separates supernatant, obtains supernatant
Liquid D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in the complex enzyme of 12g, the complex enzyme is 3:1 neutral proteinase and
Pectase first carries out 40 DEG C of enzymolysis of 30 minutes, is then decocted, and when decoction 3 is small for the first time, filtering obtains filtrate, the dregs of a decoction are again
With the water of 6 times of amounts decoct 2 it is small when, filter to get filtrate, merge filtrate twice, filtration, filtrate, which is concentrated into 80 DEG C, surveys relative densities and be
1.15-1.18 adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；By phoenix-tail fern, ten greatly
Contribution, calculus bovis factitius and radix scutellariae add 8 times of amount water to impregnate 30 minutes, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filter
It crosses, obtains filtrate F；Supernatant A, supernatant B, extract C, supernatant D, supernatant E and filtrate F are mixed evenly, then added
Enter granatum, geranium wilfordii and wheat micropowders to remix and stir evenly, add 2：1 sodium benzoate and stearic acid 20g mixes
Conjunction stirs evenly, and externally-applied soft ointment, every 15ml is made.Affected part is applied to daily morning and evening.
4 spray of embodiment
Granatum 90g pyrrosia lingua 90g geranium wilfordiis 70g
Wheat 110g Selaginella tamariscina 70g phoenix-tail ferns 34g
Chinese mahonia 26g calculus bovis factitius 11g radix scutellariaes 9g.
Said medicine is added in into customary adjuvant according to common process, spray is made.Affected part is sprayed on daily morning and evening.
5 tincture of embodiment
Granatum 110g pyrrosia lingua 70g geranium wilfordiis 90g
Wheat 90g Selaginella tamariscina 90g phoenix-tail ferns 26g
Chinese mahonia 34g calculus bovis factitius 9g radix scutellariaes 11g.
Said medicine is added in into customary adjuvant according to common process, tincture is made.It is dripped daily morning and evening in affected part.
6 liniment of embodiment
Granatum 100g pyrrosia lingua 80g geranium wilfordiis 80g
Wheat 100g Selaginella tamariscina 80g phoenix-tail ferns 30g
Chinese mahonia 30g calculus bovis factitius 10g radix scutellariaes 10g.
Said medicine is added in into customary adjuvant according to common process, liniment is made.It is wiped daily morning and evening in affected part.
Claims (9)
1. a kind of topical composition for treating burn and scald, which is characterized in that the bulk pharmaceutical chemicals of said composition, which form, is：
Granatum 50-150 parts by weight pyrrosia lingua 40-120 parts by weight geranium wilfordii 40-120 parts by weight
Wheat 50-150 parts by weight Selaginella tamariscina 40-120 parts by weight phoenix-tail fern 15-45 parts by weight
Chinese mahonia 15-45 parts by weight calculus bovis factitius 5-15 parts by weight radix scutellariae 5-15 parts by weight.
2. composition as described in claim 1, which is characterized in that the bulk pharmaceutical chemicals of said composition, which form, is：
Granatum 80-120 parts by weight pyrrosia lingua 64-96 parts by weight geranium wilfordii 64-96 parts by weight
Wheat 80-120 parts by weight Selaginella tamariscina 64-96 parts by weight phoenix-tail fern 24-36 parts by weight
Chinese mahonia 24-36 parts by weight calculus bovis factitius 8-12 parts by weight radix scutellariae 8-12 parts by weight.
3. composition as claimed in claim 1 or 2, which is characterized in that the bulk pharmaceutical chemicals of said composition, which form, is：
100 parts by weight pyrrosia lingua of granatum, 80 parts by weight geranium wilfordii, 80 parts by weight
100 parts by weight Selaginella tamariscina of wheat, 80 parts by weight phoenix-tail fern, 30 parts by weight
30 parts by weight calculus bovis factitius of Chinese mahonia, 10 parts by weight radix scutellariae, 10 parts by weight.
4. composition as described in claim 1, which is characterized in that the bulk pharmaceutical chemicals of said composition, which form, is：
60 parts by weight pyrrosia lingua of granatum, 110 parts by weight geranium wilfordii, 50 parts by weight
140 parts by weight Selaginella tamariscina of wheat, 50 parts by weight phoenix-tail fern, 40 parts by weight
20 parts by weight calculus bovis factitius of Chinese mahonia, 13 parts by weight radix scutellariae, 7 parts by weight.
5. pharmaceutical composition as described in claim 1, which is characterized in that the bulk pharmaceutical chemicals of said composition, which form, is：
140 parts by weight pyrrosia lingua of granatum, 50 parts by weight geranium wilfordii, 110 parts by weight
60 parts by weight Selaginella tamariscina of wheat, 110 parts by weight phoenix-tail fern, 20 parts by weight
40 parts by weight calculus bovis factitius of Chinese mahonia, 7 parts by weight radix scutellariae, 13 parts by weight.
6. the composition as described in one of claim 1-5, which is characterized in that the preparation method of said composition is：1/2 is taken respectively
Granatum, 1/2 geranium wilfordii and 1/2 wheat ultramicro grinding obtain micropowders, more than 85% micro mist after ultramicro grinding
Grain size is no more than 8 microns；The granatum of remainder 1/2 is cleaned, the 6-10 times of water measured is added to impregnate 15-45 minutes, is then decocted
It boils, when decoction 1-3 is small for the first time, filters to get filtrate；The dregs of a decoction again with 2-6 times of water measured decoct 1-2 it is small when, filtering obtains filtrate, closes
And filtrate, filtering, filtrate centrifuge twice, 3000rpm centrifugations centrifuge 2-6 minutes, separate supernatant, obtain supernatant A；It will
The geranium wilfordii of remainder 1/2 is impregnated 15-45 minutes with the 4-12 times of water measured, and is then decocted, and it is small to decoct 1.5-4.5 for the first time
When, filtering obtains filtrate, the dregs of a decoction again with the 3-9 times of water measured decoct 1-3 it is small when, filter to get filtrate, merge filtrate twice, filter, filter
It is 1.15-1.18 that liquid, which is concentrated into 70-90 DEG C and surveys relative density, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle second
Alcohol obtains supernatant B；By remaining 1/2 wheat ultramicro grinding to 20-60 mesh, Ultramicro-powder is placed on CO2It is impregnated in extraction kettle
When 1.5-4.5 is small, it is 20-30MPa to control pressure in extraction kettle；Ultramicro-powder after immersion in separating still is separated, is controlled
Separating pressure value is 3-9MPa in separating still processed, is heated up to 20-60 DEG C, when keeping 2.5-7.5 small, CO2Flow maintain 20-
40Kg/h；Extract C is obtained after separation；The water that pyrrosia lingua plus 4-12 times are measured impregnates 15-45 minutes, adds in answering for 15-45 parts by weight
Synthase, the complex enzyme are 1:2 pectase and cellulase first carries out the 20-60 DEG C of enzymolysis of 15-45 minutes, then carries out
It decocts, when decoction 1-3 is small for the first time, filters to get filtrate；The dregs of a decoction again with 3-9 times of water measured decoct 1-2 it is small when, filtering obtains filtrate,
Merge filtrate twice, filtering, filtrate centrifuges, and 3000rpm centrifugations centrifuge 2-6 minutes, separate supernatant, obtain supernatant D；
Selaginella tamariscina with the 4-12 times of water measured is impregnated 15-45 minutes, adds in the complex enzyme of 6-18 parts by weight, the complex enzyme is 3:In 1
Property protease and pectase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decocted, for the first time decoction 1.5-4.5
Hour, filtering obtains filtrate, the dregs of a decoction again with the 3-9 times of water measured decoct 1-3 it is small when, filter to get filtrate, merge filtrate twice, filtration,
It is 1.15-1.18 that filtrate, which is concentrated into 70-90 DEG C and surveys relative density, adds ethyl alcohol that alcohol content is made to stand up to 65%, supernatant is taken to recycle
Ethyl alcohol obtains supernatant E；4-12 times is added to measure water immersion 15-45 minutes phoenix-tail fern, Chinese mahonia, calculus bovis factitius and radix scutellariae, then
It decocts twice, when each 0.5-1.5 is small, merges decocting liquid twice, filtration obtains filtrate F；By supernatant A, supernatant B, extract C,
Supernatant D, supernatant E and filtrate F are mixed evenly, and add granatum, geranium wilfordii and wheat micropowders and remix and stir
It mixes uniformly, adds 2：1 sodium benzoate and stearic acid 10-30 parts by weight is mixed evenly, and externally-applied soft ointment is made.
7. composition as claimed in claim 6, which is characterized in that take 1/2 granatum, 1/2 geranium wilfordii and 1/2 respectively
Wheat ultramicro grinding obtains micropowders, and more than 85% grain size of micropowder is no more than 8 microns after ultramicro grinding；By remainder 1/2
Granatum is cleaned, and the water of 8 times of amounts is added to impregnate 30 minutes, is then decocted, when decoction 2 is small for the first time, is filtered to get filtrate；The dregs of a decoction
Again with the water of 4 times of amounts decoct 1.5 it is small when, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges, 3000rpm from
The heart centrifuges 4 minutes, separates supernatant, obtains supernatant A；By remainder 1/2 geranium wilfordii with 8 times amount water immersion 30 minutes, then
It is decocted, when decoction 3 is small for the first time, filtering obtains filtrate, when the dregs of a decoction are small with the water decoction 2 of 6 times of amounts again, filter to get filtrate, close
And filtrate, filtration, filtrate are concentrated into 80 DEG C and survey relative density as 1.15-1.18 twice, and ethyl alcohol is added to make alcohol content up to 65%, it is quiet
It puts, supernatant is taken to recycle ethyl alcohol, obtains supernatant B；By remaining 1/2 wheat ultramicro grinding to 40 mesh, Ultramicro-powder is placed on CO2
When immersion 3 is small in extraction kettle, it is 25MPa to control pressure in extraction kettle；Ultramicro-powder after immersion is separated in separating still,
It is 6MPa to control separating pressure value in separating still, is heated up to 40 DEG C, when holding 5 is small, CO2Flow maintain 30Kg/h；Separation
Extract C is obtained afterwards；The water that pyrrosia lingua plus 8 times are measured is impregnated 30 minutes, adds in the complex enzyme of 30 parts by weight, the complex enzyme is 1:2
Pectase and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocted, for the first time decoct 2 it is small when, filter
Filtrate；When the dregs of a decoction are small with the water decoction 1.5 of 6 times of amounts again, filtering obtains filtrate, merges filtrate twice, filtering, and filtrate centrifuges,
3000rpm is centrifuged, and is centrifuged 4 minutes, is separated supernatant, is obtained supernatant D；The Selaginella tamariscina water of 8 times of amounts is impregnated 30 minutes, adds in 12
The complex enzyme of parts by weight, the complex enzyme are 3:1 neutral proteinase and pectase first carries out 40 DEG C of enzymolysis of 30 minutes, so
After decocted, decoct for the first time 3 it is small when, filtering obtains filtrate, when the dregs of a decoction are small with the water decoctions 2 of 6 times of amounts again, filters to get filtrate,
Merge filtrate twice, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 80 DEG C and surveys relative density, and ethyl alcohol is added to make alcohol content up to 65%, quiet
It puts, supernatant is taken to recycle ethyl alcohol, obtains supernatant E；8 times of amount water is added to impregnate 30 phoenix-tail fern, Chinese mahonia, calculus bovis factitius and radix scutellariae
Minute, then decoct twice, every time 1 it is small when, merge decocting liquid twice, filtration obtains filtrate F；By supernatant A, supernatant B, extraction
Object C, supernatant D, supernatant E and filtrate F are mixed evenly, and add granatum, geranium wilfordii and wheat micropowders and mix again
Conjunction stirs evenly, and adds 2：1 sodium benzoate and 20 parts by weight of stearic acid is mixed evenly, and externally-applied soft ointment is made.
8. the pharmaceutical composition as described in one of claim 1-5, which is characterized in that said composition adds in normal according to common process
Externally-applied soft ointment, spray, liniment, powder, drops or the tincture of clinical receiving is made in rule auxiliary material.
9. application of the composition in the drug for preparing treatment burn and scald as described in one of claim 1-5.
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| CN109125640A (en) * | 2018-09-04 | 2019-01-04 | 张本梁 | A kind of topical composition and preparation method thereof for treating burn and scald |
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