CN1466988A - Chinese materia medica preparation for treating burn and scald and method for preparing the same - Google Patents
Chinese materia medica preparation for treating burn and scald and method for preparing the same Download PDFInfo
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- CN1466988A CN1466988A CNA031376371A CN03137637A CN1466988A CN 1466988 A CN1466988 A CN 1466988A CN A031376371 A CNA031376371 A CN A031376371A CN 03137637 A CN03137637 A CN 03137637A CN 1466988 A CN1466988 A CN 1466988A
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Abstract
An exterior-applied Chinese medicine for treating burn and scald is prepared from 6 Chinese-medicinal materials including phellodendron bark, coptis root, scutellaria root, astragalus root, etc through proportioning, pulverizing and further powdering. It is applied by mixing it with boiled water in Wt ratio of 1:(200-300). Its advantages are high curative effect and healing speed, and no residual scar.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, Chinese medicine preparation of especially a kind of water aqua type external-used burn and scald treating that constitutes by drug powder material and water and preparation method thereof.
Technical background
Burn and scald is normal generation the in the daily production of people, the life.The medicine of treatment burn and scald is unguentum mostly at present, mainly divides three major types:
The first kind is with the mixing of medicine essence and is dissolved in the substrate that be characterized in skin certain affinity being arranged, shortcoming is an inadequate drainage, and medicine can not fully contact with skin or wound surface.
Second class is an ointment, mainly does substrate with vaseline or lanoline etc., and also useful Oleum Sesami or Cera Flava are done substrate, and all because of fusing point is too high, inadequate drainage causes wound surface or skin surface dipping, infection etc., and analgesic effect is poor.
The 3rd class is the low melting point unguentum.The characteristics of low melting point unguentum are: with Oleum Sesami and Cera Flava mix in the proper ratio, emulsifying, cooling back forms grid framework structure like the honeycomb, with this as substrate, powder essence, Oleum Sesami mix or fused wherein.In fact, this low melting point unguentum is made up of medicine essence, Oleum Sesami and low melting point substrate three parts, promptly is said moist expose burn ointment.Low melting point burn cream dosage form has important breakthrough to the traditional drugs putty-type, changed traditional administrated method, with moistening wound surface rather than with the Therapeutic Method of dry wound surface, in the treatment of this medicine to deep ii degree burn, the method of cutting crust and surgery skin grafting that has replaced present domestic and international application, this measure academicly is a breakthrough at world burn.But, because this unguentum directly is coated in the burn wound, when changing dressings in 4--6 hour, Excreta on the skin wound and left drug must scrape off with cutter, so be difficult to accomplish harmless skin, moreover the cycle of changing dressings is short, the operating time of changing dressings is long, bear too greatly concerning the deep burn patient, healing time is long.
Summary of the invention
It is long how to overcome cicatrix and treatment cycle that the paste medicine in the burn and scald treatment causes with the incrustation of empyrosis wound surface, is urgency problem to be solved during burn and scald is treated.
The object of the invention is to provide a kind of water aqua type external-used burn and scald treating Chinese medicine preparation and preparation method thereof.
The invention discloses Chinese medicine preparation of a kind of treatment burn and scald that constitutes by drug powder material and water and preparation method thereof.Its drug powder material is prepared from by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Realgar and Calculus Bovis etc.Drug powder material and water weight ratio are: 1: 200-300.The formulation by weight of drug powder material is: Cortex Phellodendri: 40-50 part; Rhizoma Coptidis: 15-20 part; Radix Scutellariae: 15-20 part: the Radix Astragali: 10-11 part; Realgar: 1-5 part; Calculus Bovis: 5-8 part.The optimum weight ratio of drug powder material and water is: 1: 250, the optimum weight prescription of drug powder material was: Cortex Phellodendri: 45 parts; Rhizoma Coptidis: 20 parts; Radix Scutellariae: 15 parts; The Radix Astragali: 10 parts; Realgar: 3 parts; Calculus Bovis: 7 parts.
Preparation method of the present invention by get the raw materials ready, powder process, micronization and four steps of the process of preparing Chinese medicine finish.1, gets the raw materials ready:, broken standby Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Astragali difference decontamination; 2, powder process: fill a prescription by weight with Cortex Phellodendri 40-50 part; Rhizoma Coptidis 15-20 part; Radix Scutellariae 15-20 part; The weighing of Radix Astragali 10-11 part mixes, the preliminary pulverizing; Add Realgar 1-5 part again, Calculus Bovis 5-8 part uniform mixing sieves below 100 orders with the electric crusher fine powder is broken, is made into powder; 3, micronization: the above-mentioned powder of making is put into fluid energy mill or fluid energy mill, the pressure of air-flow is between 200-2000kPa, utilize the active force of high velocity air, make the purpose that produces intensive collision between the medicine and reach pulverizing, simultaneously, because the centrifugal action of high speed rotating, the medicine of pulverizing can carry out classification simultaneously, can obtain average about 10 microns uniform microgranule, its productive rate reaches 50-60%, is the drug powder material of Chinese medicine preparation of the present invention; 4, concoct: will above-mentioned drug powder material with water by weight 1: 200-300 with the immersion of drug powder material, be scattered in the boiled water, rock gently, obtain the Huang that is transparent-brown, pH value is 6.5, apparent weakly acidic suspension is Chinese medicine preparation of the present invention.
The using method of Chinese medicine preparation of the present invention: ready sterile gauze folded immerses in the Chinese medicine preparation, treat that gauze soaks into fully, fully adsorb medicine after, take out, squeeze and go redundant moisture, keep gauze not drip; Every gauze has 12 layers at least, and minimum two (24 layers) launch flat applying on wound surface with gauze, wrap up, and change dressings once every 24 hours.Gauze carries medicine and directly contact wound surface under the effect of moisture, and along with constantly being absorbed of medicine, the outer medicine of gauze replenishes from outside to inside automatically along with the osmosis of water; In order to keep wound surface to continue the fresh state of moistening and medicine, at the treatment initial stage, sprayed medicine once with needle tubing in the gauze outside every 2-4 hour for the deep burn patient.The Excreta of wound surface is adsorbed by gauze, on gauze, when changing dressings, takes away with gauze.It is clean, smooth so can to remain wound surface, repair on one side, incrustation is moved back crust and rehabilitation on one side.
The mechanism of action of this Chinese medicine preparation is: dissolving that water preparation is good and affinity interaction, can make medicine import wound tissue fast, and with the outside hydrophilic group of the phospholipid of cell membrane affinity admirably.With the drug powder material that Chinese medicines such as Cortex Phellodendri constitute, particle diameter is the 1-50 micron, and mean diameter is significantly less than vegeto-animal cell size 10-100 micron about 10 microns; The concentration of gauze Chinese medicine micropowder material is higher than the concentration of the drug powder material of wound surface far away, so the osmosis of medicine by water is easy to transmit in the past; The drug powder material is easy to be absorbed by cell tissue by cell membrane.And in the drug powder material, Cortex Phellodendri and Rhizoma Coptidis all contain berberine, have heat-clearing and toxic substances removing, anti-inflammatory analgetic, anti-infective effect; Contain Radix Scutellariae glycosides and scutellarin in the Radix Scutellariae, all have heat clearing away, removing heat from blood, hemostasis, analgesic effect; Calculus Bovis contains bilirubin, calcium salt, cholic acid, aminoacid and polypeptide, can provide required aminoacid of wound healing and various mineral again by heat-clearing and toxic substances removing; Radix Astragali saponin and multiple effective active composition and immunizing composition play a leading role to wound healing in the Radix Astragali; Realgar has detoxifcation, parasite killing, dampness, cuts cruel effect, and various pathogenic bacterias, particularly bacillus pyocyaneus are had the good restraining effect; Water can directly reduce shell temperature, and contained mineral and trace element is again that the cell growth is necessary in the water.So this Chinese medicine preparation has effects such as antiinflammatory, pain relieving, infection and wound healing be fast.During medication, be soaked in the water base Chinese medicine preparation, make gauze fully adsorb medicine, then with the directly flat wound surface that spreads on of gauze with gauze.Because of the dampness of berberine and Radix Scutellariae glycosides, remove pus, invigorate blood circulation, the effect of blood stasis dispelling, when changing dressings debridement in 24 hours, ruin material on the wound surface, comprise the tissue of downright bad and liquefaction etc., along with gauze is taken away, thus wound surface always fresh with energetic, thereby make medicine be easy to play one's part to the full, fast and the preventing from scar of wound healing, no dysfunction.
Chinese medicine preparation of the present invention is through burn and scald patient clinical trial, and none example infects, even the case of existing severe infections when being admitted to hospital after this medicine treatment, infects very fast removing, bears new granulation, and cure rate reaches 100%.
Adopt the concise and to the point treatment situation and the effect of Chinese medicine preparation treatment burn and scald of the present invention to see Table 1.II °, dark 100 routine burn patients statistics more than II °, wherein the adult accounts for that the child accounts for 60% below 40%, 10 years old with treatment burn degree; 84 years old age the most all the year round, minimum 7 months.Therapeutic Method launches flat applying on wound surface for the sterile gauze that will soak medicine, wraps up.Changed dressings once every 24 hours, at the treatment initial stage, sprayed medicine once with needle tubing in the gauze outside every 2-4 hour for the deep burn patient.
The Chinese medicine preparation therapeutic effect of table 1 water aqua type treatment burn and scald
* annotate: the estimation of depth of burn, spend on the basis of quarterings in three of national generally employing at present, expand to three degree, five point-scores promptly: II °, dark II °, shallow III °, III °, dark III ° (dark III °: corium is dark brown, hide-like, outer tissue completely without, outer skin and comes off).
| Burn cause | Total routine number | Burn degree * | Healing time | Cure rate | Effect |
| Hydrothermal solution is scalded (hot water, deep fat, steam are scalded) | ? ? ??65 ? ? | II °, dark II °, III °, dark III ° | 5-40 days | ? ? ??100％ ? ? | No cicatrix |
| Flame burn (comprising gasoline, coal gas, acetylene, electric arc) | ? ? ??24 ? ? | II °, dark II °, III °, dark III ° | 7-40 days | ? ? ??100％ ? ? | No cicatrix |
| Electric burn | ??6 | Dark II °, III ° dark III ° | 7-15 days (wherein 1 example is hindered to bone, 30 days) | ??100％ | No cicatrix |
| Chemical burn (strong acid-base, Colophonium, yellow phosphorus) | ??2 | Dark III ° | 20-30 days | ??100％ | Melanin is not painted, recovery process is long, needs half a year to one year approximately |
| Other heating power burn (molten metal) | ??3 | Dark III ° | 20-30 days | ??100％ |
The contrast material of MEIBAO SHIRUN SHAOSHANG GAO and wet exposing therapy sees Table 2.Disclose Wuxi City institute of traditional Chinese medicine surgical intervention burn patient 61 routine clinical reports in the table, wherein the adult accounts for that the child accounts for 38% below 62%, 10 years old; 73 years old age the most all the year round, minimum 12 months.Therapeutic Method is changed dressings once every 4-6 hour for unguentum directly is coated in the burn wound, and Excreta on the skin wound and left drug must scrape off with cutter.
Table 2 MEIBAO SHIRUN SHAOSHANG GAO and wet exposing therapy (61 routine clinical report)
| Burn cause | Total routine number | The burn degree | Healing time | Cure rate, effect |
| Hydrothermal solution (hot water deep fat, scald, steam, hot soup) | 49 | Most II °-dark II ° and III ° | Average stay 17.1 days, 62 days hospital stayss at most. | Traumatic infection 5 examples (8.2%); Wound surface 2 examples (3.3%) of making skin graft; Wound surface cicatrix 6 examples (9.8%); Wound surface spontaneous recovery 55 examples (96.7%). |
| Flame burn | 7 | |||
| Electric burn | 2 | |||
| Lime water | 1 | |||
| Molten steel is scalded | 2 |
The result of comparison sheet 1 and table 2 can clearly be seen that: Chinese medicine preparation treatment burn and scald of the present invention all obviously is better than MEIBAO SHIRUN SHAOSHANG GAO and wet exposing therapy thereof in the cycle of changing dressings and cure rate, effect etc. aspect a lot.
1), keep wound surface moistening and do not flood this Chinese medicine preparation clinical test results shows that it has following advantage:; 2), non-viable non-apoptotic cell tissue and left drug take away with gauze when changing dressings, tissue of burn can obtain the fresh medicine than steady concentration all the time; 3), isolating wound surface not invaded and harassed by external source; 4), this Chinese medicine preparation is faintly acid, has the good compatibility with the epidermis cell tissue, promotes burn wound's microcirculation to recover effectively, promotes stem cell growth, growth, promotes tendon, blood capillary, skin follicle regeneration to restore; 5), there are not infection, no sepsis; 6), pain relieving at once.7), anti-septicopyemia, antibacterial, healing is fast, to dark II, III degree burn treating, preventing from scar.8), Chinese medicine preparation makes simply, easy to operate, medication is convenient.Not limited by medical condition, factory floor and military first aid and rural hospital and family ward all can use, and are more suitable in large hospital, section hospital and to the treatment of pediatric patient.
The specific embodiment
Embodiment one: weighing Cortex Phellodendri 4.5kg by weight fills a prescription; Rhizoma Coptidis 2.0kg; Radix Scutellariae 1.5kg; Radix Astragali 1kg, Realgar 0.3kg and Calculus Bovis 0.7kg, through get the raw materials ready, powder process, micronization, the process of preparing Chinese medicine makes Chinese medicine preparation of the present invention.
Embodiment two: 1, get the raw materials ready:, broken standby Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Astragali decontamination respectively; 2, powder process: by weight ratio with Cortex Phellodendri 4kg; Rhizoma Coptidis 2kg; Radix Scutellariae 2kg; Radix Astragali 1kg weighing mixes, the preliminary pulverizing; Add Realgar 0.5kg again; Calculus Bovis 0.5 uniform mixing; sieve below 100 orders with the electric crusher fine powder is broken; be made into powder 3; micronization: the above-mentioned powder of making is put into fluid energy mill; the pressure of air-flow is 1000kPa; get uniform micropowder below 10 microns; its productive rate is 50%; be the drug powder material 4 of this preparation; concoct: above-mentioned drug powder material and water were soaked drug powder material 1g by weight 1: 250; be scattered in the 250g boiled water; rock gently; obtain the Huang that is transparent-brown; pH value is 6.5, shows weakly acidic suspension, is Chinese medicine preparation of the present invention.
Claims (6)
1, a kind of exterior-applied liquid medicine dosage form Chinese medicine preparation for the treatment of burn and scald is characterized in that it makes the drug powder material by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Realgar and Calculus Bovis, and wherein each composition weight prescription is:
Cortex Phellodendri: 40-50 part Rhizoma Coptidis: 15-20 part
Radix Scutellariae: 15-20 part Radix Astragali: 10-11 part
Realgar: 1-5 part Calculus Bovis: the weight ratio of 5-8 part medicine differential material and water is: 1: 200-300.
2, Chinese medicine preparation as claimed in claim 1 is characterized in that the optimum weight prescription of described drug powder material is:
Cortex Phellodendri: 45 portions of Rhizoma Coptidis: 20 parts
Radix Scutellariae: 15 parts of Radixs Astragali: 10 parts
Realgar: 3 parts of Calculus Boviss: the weight ratio of 7 parts of drug powder material and water is 1: 250.
1), get the raw materials ready 3, a kind of preparation method of Chinese medicine preparation according to claim 1 is characterized in that it comprises the step of carrying out in the following order:; 2), powder process; 3), micronization; 4), concoct.
4, the preparation method of Chinese medicine preparation as claimed in claim 3, it is characterized in that getting the raw materials ready is meant Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Astragali difference decontamination, broken standby; Powder process is meant that the weighing Cortex Phellodendri of filling a prescription by weight, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali mix, the preliminary pulverizing; Add Realgar, Calculus Bovis uniform mixing again, fine powder is broken to sieve below 100 orders, makes powder; Micronization is meant puts into fluid energy mill or fluid energy mill with powder, and the pressure of air-flow obtains average about 10 microns uniform drug powder material between 200-2000kPa; The process of preparing Chinese medicine is meant that the drug powder material that will make through above-mentioned steps and boiled water are by weight 1: 200-300 with its immersion, be scattered in the boiled water, rock gently, obtain suspension.
5, as claim 3 or 4 described preparation methoies, it is characterized in that described micronization is meant powder is put into fluid energy mill, the pressure of air-flow is 1000kPa, drug powder material uniformly below 10 microns.
6, as claim 3 or 4 described preparation methoies, it is characterized in that the described process of preparing Chinese medicine is meant described drug powder material 1g immersion, is scattered in the 250g boiled water, rock gently, obtain suspension.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306187B (en) * | 2008-07-16 | 2011-01-05 | 卜继武 | Topical paste for treating burns and its production method |
| CN101468171B (en) * | 2007-12-28 | 2011-08-24 | 何顺洪 | Medicament for weight-reducing of fat people and weight-gaining of thin people |
| CN101385799B (en) * | 2007-09-12 | 2012-07-04 | 罗善兵 | Chinese herbal medicine for treating empyrosis |
| CN101732567B (en) * | 2008-11-20 | 2013-01-30 | 吴雅琳 | Medicament for treating burns and preparation method thereof |
| CN106075538A (en) * | 2016-06-08 | 2016-11-09 | 成都森科制药有限公司 | Adhesion protective oil sliver and manufacture craft thereof |
| CN108079219A (en) * | 2018-02-05 | 2018-05-29 | 尹心刚 | A kind of topical composition for treating burn and scald and preparation method thereof |
-
2003
- 2003-06-09 CN CNB031376371A patent/CN1211115C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385799B (en) * | 2007-09-12 | 2012-07-04 | 罗善兵 | Chinese herbal medicine for treating empyrosis |
| CN101468171B (en) * | 2007-12-28 | 2011-08-24 | 何顺洪 | Medicament for weight-reducing of fat people and weight-gaining of thin people |
| CN101306187B (en) * | 2008-07-16 | 2011-01-05 | 卜继武 | Topical paste for treating burns and its production method |
| CN101732567B (en) * | 2008-11-20 | 2013-01-30 | 吴雅琳 | Medicament for treating burns and preparation method thereof |
| CN106075538A (en) * | 2016-06-08 | 2016-11-09 | 成都森科制药有限公司 | Adhesion protective oil sliver and manufacture craft thereof |
| CN108079219A (en) * | 2018-02-05 | 2018-05-29 | 尹心刚 | A kind of topical composition for treating burn and scald and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1211115C (en) | 2005-07-20 |
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