CN108815268A - A kind of external application promotees the Chinese medicine ointment formulation and preparation method thereof of union of wounded skin - Google Patents
A kind of external application promotees the Chinese medicine ointment formulation and preparation method thereof of union of wounded skin Download PDFInfo
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Abstract
The present invention relates to Chinese medicine ointment formulation fields, promote the Chinese medicine ointment formulation and preparation method thereof of union of wounded skin more particularly to a kind of external application, and Chinese medicine ointment formulation is made of active ingredient of Chinese herbs and matrix auxiliary material, by mass percentage：Active ingredient of Chinese herbs 43.5%, matrix auxiliary material 56.5%；The active ingredient of Chinese herbs includes the following components'mass percentage：Semen Strychni (processed) extract 8.5%-9.5%, safflower extract 8.5%-9%, Olibanum extract 8.5%-9%, Myrrha extract 8.5%-9%, Herba Asari extract 5.5%-6%, Salvia root P.E 0.5%-1%, spikemoss extract 0.5%-1%, Folium Et Cacumen Murrayae extract 0.5%-1%.The present invention, which has, promotees union of wounded skin, the anti-anti- anti-scar of infection of the anti-pain that swells, the multiple functions such as swelling and pain relieving, expelling the stasis for the new, clearing and activating the channels and collaterals, healthy skin tissue；Present invention process process is shorter, is easy to batch machining production.
Description
Technical field
The present invention relates to Chinese medicine ointment formulation fields, promote the traditional Chinese herb medicine of union of wounded skin more particularly to a kind of external application
Preparation and preparation method thereof.
Background technique
The research of union of wounded skin is the important topic of medical field, and the research of motherland's medicine and pharmacology in this respect has long
History, early in written by Southern Qi Dynasty's epoch (479-502) Gong Qingxuan《The something lost side Liu Juanzi》Just there is external injury reason to emphasize hemostasis, stop
Bitterly, the record that convergence, calm, removing toxic substances etc. are cured wound speed.
Union of wounded skin is a series of complex, continuous biochemistry and cellular activity process, can be simply summarised as：
Blood coagulation, inflammation, matrix synthesis and deposition, microcirculation generation, fibr tissue formation, epithelialization, Wound Contraction and remodeling.In wound
The participation of a variety of factors, cell, enzyme is needed during healing, and is interacted each other, and wound healing can be just made.Skin
Wound belongs to traditional Chinese medicine " ulcer, early stage of pyogenic infection of skin, sore " scope, it is believed that sore pathogenesis is qi depression to blood stasis, and hemostasis stagnates channels and collaterals, gas
The blood interruption of service, new blood are not given birth to, and the surface of a wound lacks nutrition, and granulation tissue is then difficult to generate, therefore Chinese medicine is often with promoting blood circulation drug
Promoting blood circulation, hemostasis, analgesic, myogenic treat chronic wound, and often receive good therapeutic effect.Meanwhile modern pharmacological research
Think that drug for invigorating blood circulation and eliminating stasis has apparent anti-inflammatory effect, increases surface of a wound capillary permeability, inflammatory cell is largely oozed out, soaked
Profit, and downright bad substance can be removed in time, promote Wound fibroblasts synthesis and extracellular matrix secretion and various growth factors,
Accelerate surface of a wound vascularization process, is conducive to the stem cells hyperplasia of surface of a wound circumferential skin, migration, differentiation, and then promote wound repair.Wherein
Trauma surface infestation is an important factor for influencing wound healing.Modern pharmacology confirms that many Chinese medicines have bactericidal bacteriostasis or can mention
The comprehensive antibacterial ability of high body, promotees more to play the role of the surface of a wound.
But the therapeutic effect of Wound healing and bone regeneration agent in the prior art is not good enough, medication side effect is obvious, and wound is easy sense
Dye, healing time is slow, easily stays scar.
Summary of the invention
The object of the present invention is to provide the Chinese medicine ointment formulations and preparation method thereof that a kind of external application promotees union of wounded skin, originally
The Chinese medicine ointment formulation of invention, which has, promotees union of wounded skin, the anti-anti- anti-scar of infection of the anti-pain that swells, swelling and pain relieving, expelling the stasis for the new,
The multiple functions such as clearing and activating the channels and collaterals, healthy skin tissue；Chinese medicine ointment formulation of the invention property safe to the human body is high and effect is good, surely
It is qualitative good；And raw material sources of the invention are extensive, are easy to collect, preparation method process flow of the invention is shorter, is easy to batch
Processing.
The purpose of the present invention is achieved through the following technical solutions：
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, it is by active ingredient of Chinese herbs and matrix auxiliary material system
At by mass percentage：Active ingredient of Chinese herbs 43.5%, matrix auxiliary material 56.5%；The active ingredient of Chinese herbs include with
The component of lower mass percent：Semen Strychni (processed) extract 8.5%-9.5%, safflower extract 8.5%-9%, Olibanum extract
8.5%-9%, Myrrha extract 8.5%-9%, Herba Asari extract 5.5%-6%, Salvia root P.E 0.5%-1%, Selaginella tamariscina mention
Take object 0.5%-1%, Folium Et Cacumen Murrayae extract 0.5%-1%.
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, in the active ingredient of Chinese herbs, each component
By best in quality percentage：Semen Strychni (processed) extract 8.7%, safflower extract 8.7%, Olibanum extract 8.7%, myrrh extract
Object 8.7%, Herba Asari extract 5.7%, Salvia root P.E 1%, spikemoss extract 1%, Folium Et Cacumen Murrayae extract 1%.
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, and the matrix auxiliary material includes following quality hundred
Divide the component of ratio：Lanolin 40%, atoleine 14%, penetrating agent 2.5%.
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, and the matrix auxiliary material includes following quality hundred
Divide the component of ratio：Purified water 45.25%, propylene glycol 10%, triethanolamine 0.75%, Acritamer 940 0.5%.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, and specific step is as follows：
Step 1: by mass percentage, taking lanolin and atoleine, lanolin and atoleine are mixed and melted, is obtained
Emulsifier；
Step 2: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, myrrh is taken to extract
Object, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly,
Obtain active ingredient of Chinese herbs；
Active ingredient of Chinese herbs is added to emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs simultaneously disperses
In emulsifier, active ingredient of Chinese herbs is emulsified agent package, and the translucent Chinese medicinal ingredients emulsion containing active ingredient of Chinese herbs is made,
It is spare；
Step 3: by mass percentage, taking penetrating agent, penetrating agent is dissolved in translucent Chinese medicinal ingredients emulsion, water-bath
Heating after at the uniform velocity stirring 2 minutes, stops heating stirring, the active Chinese drug component inside penetrating agent and translucent Chinese medicinal ingredients emulsion
Ingredient and emulsifier sufficiently dissolve each other, and form the colloid of oily；Chinese medicine ointment formulation is made after cooling.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, in the step 1, sheep
Hair rouge and atoleine carry out mixing thawing by the way of heating water bath, and the temperature of heating water bath is 85 DEG C.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, in the step 2, system
Semen Strychni extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Salvia root P.E, Selaginella tamariscina are extracted
Object, Folium Et Cacumen Murrayae extract were all the fine powder of 90-500 mesh；In the step 2, Semen Strychni (processed) extract, safflower extract,
Olibanum extract, Myrrha extract, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract are all using super
Critical CO2Abstraction technique carries out supercritical CO2Fluid circulation extraction, which is collected, to be made.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, and specific step is as follows：
Step 1: by mass percentage, after taking propylene glycol to be sufficiently humidified so as to Acritamer 940, purified water being added, stands one section
Time is swollen Acritamer 940 sufficiently, forms aquation carbomer colloid；
Step 2: by mass percentage, taking triethanolamine to be added in aquation carbomer colloid and slowly stirring, obtain translucent
Emulsifier；
Step 3: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, myrrh is taken to extract
Object, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly,
Obtain active ingredient of Chinese herbs；
Active ingredient of Chinese herbs is added to translucent emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs
And be dispersed in translucent emulsifier, active ingredient of Chinese herbs is wrapped up by translucent emulsifier, that is, is made containing active ingredient of Chinese herbs
Ointment formulation.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, in the step 3, system
Semen Strychni extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Salvia root P.E, Selaginella tamariscina are extracted
Object, Folium Et Cacumen Murrayae extract be all 90-500 mesh fine powder or Semen Strychni (processed) extract, safflower extract, Olibanum extract,
Myrrha extract, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract are all using supercritical CO2Extraction
Technology carries out supercritical CO2Fluid circulation extraction, which is collected, to be made.
Beneficial effects of the present invention：Chinese medicine ointment formulation of the invention, which has, promotees union of wounded skin, the anti-anti- sense of anti-pain of swelling
Contaminate anti-scar, the multiple functions such as swelling and pain relieving, expelling the stasis for the new, clearing and activating the channels and collaterals, healthy skin tissue；Traditional Chinese herb medicine system of the invention
Agent property safe to the human body is high and effect is good, and stability is good；And raw material sources of the invention are extensive, are easy to collect, system of the invention
Preparation Method process flow is shorter, is easy to batch machining production.
Compared with prior art, the present invention has the following advantages that：
The present invention passes through the functional trial of each active ingredient of Chinese herbs, it is determined that active ingredient of Chinese herbs is in ointment formulation
Additive amount, the present invention have effects that have swelling and pain relieving, expelling the stasis for the new, clearing and activating the channels and collaterals and skin wounds obvious skin wound
The anti-scar promoting healing of the anti-infection of the anti-anti- pain that swells effect.The present invention is tested by the compatibility of emulsifier and active ingredient of Chinese herbs
The emulsifier component and dosage of package active ingredient of Chinese herbs is determined, so that the state of the active ingredient of Chinese herbs after package is more steady
It is fixed, overcome the problems, such as that traditional Chinese medicine ingredients are difficult to adhere on skin wounds, the compatibility of a variety of effective active Chinese drug component compositions makes the present invention
The effect of better than other preparations, the present invention passes through clinical experiments have proved that nontoxic, without side-effects.
Active ingredient of Chinese herbs inside the present invention is derived from natural, property height safe to the human body；Promoting healing repair is rapid,
Swelling and pain relieving effect is obvious；Ointment quality is fine and smooth, it is easier to be absorbed by the skin, therefore have the function of good appearance and.
A kind of external application of the invention promotees the Chinese medicine ointment formulation of union of wounded skin, during development and production, on the one hand
The effect of determining the traditional Chinese medicine ingredients compatibility of addition by clinical test and its additive amount in the formulation, and combine activity in Chinese medicine
The effect of ingredient, so that ointment formulation of the invention has to wound swelling and pain relieving, expelling the stasis for the new, clearing and activating the channels and collaterals and repairs skin
Undertissue promotees more to wait multi-efficiencies；On the other hand suitable emulsifier is screened, bleeding agent wraps up active ingredient of Chinese herbs, to overcome
Active ingredient of Chinese herbs is difficult to the limitation of Transdermal absorption, and it is fine that the active ingredient of Chinese herbs after package can seep composition with other transdermal rush
Ground dissolves each other, and with other compositions compatibility well, stability and Transdermal absorption the effect of to ensure traditional Chinese medicine ingredients continue
Property.
Each taste raw material pharmacology contained by natural traditional Chinese medicine active constituent used in the present invention is as follows：
Semen Strychni (processed)：For the dry mature seed of loganiaceae plant S. pierriana；The main component of Semen Strychni (processed) is scholar
Rather, clinically there are reduction " erythrocyte sedimentation rate " and " anti-O "；Semen Strychni (processed) is that Chinese medicine relieves pain most effective one of drug, and has
The effect of antiphlogistic antibacterial, promoting blood circulation and removing obstruction in channels, relaxing tendons and activating collaterals, expelling the stasis for the new；
Safflower：Alias red blue flower, thorn safflower, composite family, safflower plant, dry tubular flower is orange red, and floral tube is narrow thin,
Apex 5 is split, sliver narrow line shape, and anther yellow is unified into pipe, is higher by except sliver, and there is column cap exposing in center；Tool is special fragrant
Gas, mildly bitter flavor；Blood circulation, removing blood stasis and acesodyne facilitate controlling through closing, dysmenorrhea, lochia, chest impediment and cardialgia, stasis of blood, chest side of body
Shouting pain, the treatment of traumatic injury, sore swell and ache curative；There is the effect of activating microcirculation and removing stasis medicinal, dissipate wet effect going to swell；
Olibanum：The resin oozed out for olive subject plant Boswellia carterii and congener bark；There are blood-activating and qi-promoting analgesic, detumescence life
The effect of flesh；
Myrrh：For olive subject plant Chinese violet tree or the dry resin of Ha Didingshu；With scattered stasis pain, the function of detumescence and promoting granulation
Effect；
Asarum：There is cold dispelling wind-dispelling, relieves pain, the effect of warming lung and resolving fluid is sensible, inducing diaphoresis；
Radix Salviae Miltiorrhizae, Apocenosis pain relieving, myogenic are put on flesh；Broken place blood, mends new green blood Radix Salviae Miltiorrhizae bitter, micro-pungent, cold nature；The heart, spleen, liver,
The medicine of kidney blood system；With promoting blood circulation, the effect of nourishing blood and tranquilization, cool blood detumescence；Hemostasis arthralgia is cured mainly, is beaten the stasis of blood swell, sore
Ulcer pyogenic infections, red rash scabies；
Selaginella tamariscina, it is pungent, it puts down；Enter spleen, liver two passes through；Effect：Blood-breaking dissipates the stasis of blood, and Selaginella tamariscina acrid flavour, mild-natured tepor, pungent scattered temperature is logical,
Promoting the circulation of qi blood-breaking, scattered stasis pain, with abdominal pain is controlled, amenorrhoea and lump in the abdomen lump in the abdomen etc. are demonstrate,proved；Promoting blood circulation and hemostasis, this product pungent-warm, pungent scattered temperature is logical, and it is fixed to dissipate the stasis of blood
Bitterly, with controlling the various blood troubles such as haematemesis, hematochezia, hematuria, traumatic injury and metrorrhagia and metrostaxis；
Kamuning, promoting the circulation of qi, promoting blood circulation, wind-dispelling, dehumidifying, and have analgesia effect；Stomach duct and abdomen gas pain is controlled, is had a stomachache, rheumatic arthralgia,
Pyogenic infections, scabies, pruitus, treating swelling and pain by traumatic injury, toothache, worm snake bite.
The compatibility explanation of natural traditional Chinese medicine active constituent used in the present invention：
Semen Strychni (processed), expelling the stasis for the new, promoting blood circulation and stopping pain are monarch drug in a prescription.
Olibanum, detumescence and promoting granulation analgesic therapy；Myrrh, detumescence and promoting granulation hemostasis；Radix Salviae Miltiorrhizae, apocenosis myogenic pain relieving；Olibanum, myrrh, Radix Salviae Miltiorrhizae
It is altogether ministerial drug.
Safflower, gas perfume (or spice) row dissipate, and enter blood system, and promoting blood circulation, dredging channels, removing blood stasis and relieving pain helps the monarch and his subjects' drug to enter blood system, humidification, for assistant
Help medicine.
Kamuning, promoting the circulation of qi, promoting blood circulation, and have analgesia effect, worm snake bite is controlled, is supplementary drug.
Selaginella tamariscina, blood-breaking dissipate the stasis of blood, and restriction myogenic is excessive, prevents scar hyperplasia, are corrigent.
Asarum, relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, the pungent key that scatters guide drugs to illness station all medicines, are official's medicine；In addition, asarum also has
Anti inflammatory immunity, improves metabolism, antibacterial action at local anaesthesia.
All medicines match, expelling the stasis for the new, blood circulation, dissipate blood detumescence, hemostasis and pain-relieving；It acts on traumatic surface and plays myogenic and stop
Blood and relieving pain, the anti-anti- infection scar of anti-pain that swells is anti-, promotes skin healing and other effects.
The present invention is proved through a large amount of clinical practices, is had no toxic side effect, no safety problem；Since active ingredient of Chinese herbs is derived from
Naturally, property safe to the human body is high；Plurality of Chinese active constituent collective effect in ointment formulation, so that there is the present invention detumescence to stop
Bitterly, expelling the stasis for the new, clearing and activating the channels and collaterals, healthy wound skin histology function multi-efficiency；Quality of the present invention is fine and smooth, it is easier to be inhaled by skin
It receives, therefore with good character and brilliant practical application.
Technological advantage of the invention is：1, selection raw material science, production technology are advanced；2, raw material sources are extensive, processing
Skill route is short, the manufacture of product easy processing.
Specific embodiment
The preferred embodiment of the present invention is illustrated in detail below.
Specific embodiment one：
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, it is by active ingredient of Chinese herbs and matrix auxiliary material system
At by mass percentage：Active ingredient of Chinese herbs 43.5%, matrix auxiliary material 56.5%；The active ingredient of Chinese herbs include with
The component of lower mass percent：Semen Strychni (processed) extract 8.5%-9.5%, safflower extract 8.5%-9%, Olibanum extract
8.5%-9%, Myrrha extract 8.5%-9%, Herba Asari extract 5.5%-6%, Salvia root P.E 0.5%-1%, Selaginella tamariscina mention
Take object 0.5%-1%, Folium Et Cacumen Murrayae extract 0.5%-1%.
In the active ingredient of Chinese herbs, each component presses best in quality percentage：Semen Strychni (processed) extract 8.7%, safflower mention
Take object 8.7%, Olibanum extract 8.7%, Myrrha extract 8.7%, Herba Asari extract 5.7%, Salvia root P.E 1%, Selaginella tamariscina
Extract 1%, Folium Et Cacumen Murrayae extract 1%.
The matrix auxiliary material includes the following components'mass percentage component：Lanolin 40%, atoleine 14%, penetrating agent
2.5%.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, and specific step is as follows：
Step 1: by mass percentage, taking lanolin and atoleine, lanolin and atoleine are mixed and melted, is obtained
Emulsifier；
Step 2: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, myrrh is taken to extract
Object, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly,
Obtain active ingredient of Chinese herbs；
Active ingredient of Chinese herbs is added to emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs simultaneously disperses
In emulsifier, active ingredient of Chinese herbs is emulsified agent package, and the translucent Chinese medicinal ingredients emulsion containing active ingredient of Chinese herbs is made,
It is spare；
Step 3: by mass percentage, taking penetrating agent, penetrating agent is dissolved in translucent Chinese medicinal ingredients emulsion, water-bath
Heating after at the uniform velocity stirring 2 minutes, stops heating stirring, the active Chinese drug component inside penetrating agent and translucent Chinese medicinal ingredients emulsion
Ingredient and emulsifier sufficiently dissolve each other, and form the colloid of oily；Chinese medicine ointment formulation is made after cooling.
In the step 1, lanolin and atoleine carry out mixing thawing, heating water bath by the way of heating water bath
Temperature be 85 DEG C.
In the step 2, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, asarum are extracted
Object, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract were all the fine powder of 90-500 mesh；In the step 2, horse processed
Money seed extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Salvia root P.E, spikemoss extract,
Folium Et Cacumen Murrayae extract is all using supercritical CO2Abstraction technique carries out supercritical CO2Fluid circulation extraction, which is collected, to be made.
Specific embodiment two：
A kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, it is by active ingredient of Chinese herbs and matrix auxiliary material system
At by mass percentage：Active ingredient of Chinese herbs 43.5%, matrix auxiliary material 56.5%；The active ingredient of Chinese herbs include with
The component of lower mass percent：Semen Strychni (processed) extract 8.5%-9.5%, safflower extract 8.5%-9%, Olibanum extract
8.5%-9%, Myrrha extract 8.5%-9%, Herba Asari extract 5.5%-6%, Salvia root P.E 0.5%-1%, Selaginella tamariscina mention
Take object 0.5%-1%, Folium Et Cacumen Murrayae extract 0.5%-1%.
In the active ingredient of Chinese herbs, each component presses best in quality percentage：Semen Strychni (processed) extract 8.7%, safflower mention
Take object 8.7%, Olibanum extract 8.7%, Myrrha extract 8.7%, Herba Asari extract 5.7%, Salvia root P.E 1%, Selaginella tamariscina
Extract 1%, Folium Et Cacumen Murrayae extract 1%.
The matrix auxiliary material includes the following components'mass percentage component：Purified water 45.25%, propylene glycol 10%, three ethyl alcohol
Amine 0.75%, Acritamer 940 0.5%.
A kind of external application promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, and specific step is as follows：
Step 1: by mass percentage, after taking propylene glycol to be sufficiently humidified so as to Acritamer 940, purified water being added, stands one section
Time is swollen Acritamer 940 sufficiently, forms aquation carbomer colloid；
Step 2: by mass percentage, taking triethanolamine to be added in aquation carbomer colloid and slowly stirring, obtain translucent
Emulsifier；
Step 3: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, myrrh is taken to extract
Object, Herba Asari extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly,
Obtain active ingredient of Chinese herbs；
Active ingredient of Chinese herbs is added to translucent emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs
And be dispersed in translucent emulsifier, active ingredient of Chinese herbs is wrapped up by translucent emulsifier, that is, is made containing active ingredient of Chinese herbs
Ointment formulation.
In the step 3, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, asarum are extracted
Object, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract were all the fine powder of 90-500 mesh；
The Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Radix Salviae Miltiorrhizae mention
Taking object, spikemoss extract, Folium Et Cacumen Murrayae extract is all using supercritical CO2Abstraction technique carries out supercritical CO2Fluid circulation extraction
It collects and is made.
The clinical effectiveness that a kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin is as follows：
Case one：Liu, male 48 years old, Heilungkiang people from Hailin because of wound to forehead, face's wound and infects, uses this hair
Chinese medicine ointment formulation made of bright specific embodiment two, after external curing 15 days, for wound without redness, color is normal, congestive
Exudation, surface of a wound scar is very thin, and substantially without contracture, healing is good, and illing skin is normal, clinical cure.
Case two：Sun, male 36 years old, Heilungkiang grand celebration people, because wound to shank trauma surface infestation uses this as deep as bone face
Chinese medicine ointment formulation made of invention specific embodiment two, after external curing 30 days, surface of a wound recovery from illness, wound is without redness, no scar
Trace, no sequel.
Case three：Tang, female 32 years old, Heilungkiang people from Shuangyashan, because fire to whole body 50% is burnt, using of the invention specific
It after Chinese medicine ointment formulation made of embodiment two, relieves pain immediately, after external curing 60 days, has grown fresh granulation tissue,
Subcutaneous tissue, clinical cure, no sequel are repaired in success.
Proved through a large amount of clinical practices, in ointment formulation of the invention have swelling and pain relieving, expelling the stasis for the new, clearing and activating the channels and collaterals,
Healthy wound skin histology function multi-efficiency；Ointment formulation quality of the invention is fine and smooth, it is easier to be absorbed by the skin.
Certainly, above description is not limitation of the present invention, and the present invention is also not limited to the example above, the art
The variations, modifications, additions or substitutions that those of ordinary skill is made within the essential scope of the present invention also belong to guarantor of the invention
Protect range.
Claims (9)
1. a kind of external application promotees the Chinese medicine ointment formulation of union of wounded skin, it is made of active ingredient of Chinese herbs and matrix auxiliary material,
It is characterized in that, by mass percentage：Active ingredient of Chinese herbs 43.5%, matrix auxiliary material 56.5%；The active Chinese drug component at
Divide and includes the following components'mass percentage component：Semen Strychni (processed) extract 8.5%-9.5%, safflower extract 8.5%-9%, olibanum
Extract 8.5%-9%, Myrrha extract 8.5%-9%, Herba Asari extract 5.5%-6%, Salvia root P.E 0.5%-1%,
Spikemoss extract 0.5%-1%, Folium Et Cacumen Murrayae extract 0.5%-1%.
2. the Chinese medicine ointment formulation that a kind of external application according to claim 1 promotees union of wounded skin, which is characterized in that described
In active ingredient of Chinese herbs, each component presses best in quality percentage：Semen Strychni (processed) extract 8.7%, safflower extract 8.7%, cream
Fragrant extract 8.7%, Myrrha extract 8.7%, Herba Asari extract 5.7%, Salvia root P.E 1%, spikemoss extract 1%, nine
In fragrant extract 1%.
3. the Chinese medicine ointment formulation that a kind of external application according to claim 2 promotees union of wounded skin, which is characterized in that described
Matrix auxiliary material includes the following components'mass percentage component：Lanolin 40%, atoleine 14%, penetrating agent 2.5%.
4. the Chinese medicine ointment formulation that a kind of external application according to claim 2 promotees union of wounded skin, which is characterized in that described
Matrix auxiliary material includes the following components'mass percentage component：Purified water 45.25%, propylene glycol 10%, triethanolamine 0.75%, card wave
Nurse 9400.5%.
5. a kind of external application according to claim 3 promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, special
Sign is that specific step is as follows：
Step 1: by mass percentage, taking lanolin and atoleine, lanolin and atoleine are mixed and melted, must be emulsified
Agent；
Step 2: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, thin is taken
Pungent extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly, and obtain Chinese medicine
Active constituent；
Active ingredient of Chinese herbs is added to emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs is simultaneously dispersed in cream
In agent, active ingredient of Chinese herbs is emulsified agent package, and the translucent Chinese medicinal ingredients emulsion containing active ingredient of Chinese herbs is made, standby
With；
Step 3: by mass percentage, taking penetrating agent, penetrating agent is dissolved in translucent Chinese medicinal ingredients emulsion, water-bath heating,
After at the uniform velocity stirring 2 minutes, stop heating stirring, active ingredient of Chinese herbs inside penetrating agent and translucent Chinese medicinal ingredients emulsion and
Emulsifier sufficiently dissolves each other, and forms the colloid of oily；Chinese medicine ointment formulation is made after cooling.
6. a kind of external application according to claim 5 promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, special
Sign is, in the step 1, lanolin and atoleine carry out mixing thawing by the way of heating water bath, heating water bath
Temperature is 85 DEG C.
7. a kind of external application according to claim 6 promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, special
Sign is, in the step 2, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, asarum are extracted
Object, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract were all the fine powder of 90-500 mesh；
The Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Radix Salviae Miltiorrhizae extract
Object, spikemoss extract, Folium Et Cacumen Murrayae extract are all using supercritical CO2Abstraction technique carries out supercritical CO2Fluid circulation extraction is received
Collection is made.
8. a kind of external application according to claim 4 promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, special
Sign is that specific step is as follows：
Step 1: by mass percentage, after taking propylene glycol to be sufficiently humidified so as to Acritamer 940, purified water is added, when standing one section
Between, it is swollen Acritamer 940 sufficiently, forms aquation carbomer colloid；
Step 2: by mass percentage, taking triethanolamine to be added in aquation carbomer colloid and slowly stirring, obtain translucent emulsification
Agent；
Step 3: by mass percentage, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, thin is taken
Pungent extract, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract, are placed in mixing machine after being mixed evenly, and obtain Chinese medicine
Active constituent；
Active ingredient of Chinese herbs is added to translucent emulsifier, is mixed again, the abundant homogeneous of active ingredient of Chinese herbs simultaneously divides
It is dispersed in translucent emulsifier, active ingredient of Chinese herbs is wrapped up by translucent emulsifier, that is, the ointment containing active ingredient of Chinese herbs is made
Preparation.
9. a kind of external application according to claim 8 promotees the preparation method of the Chinese medicine ointment formulation of union of wounded skin, special
Sign is, in the step 3, Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, asarum are extracted
Object, Salvia root P.E, spikemoss extract, Folium Et Cacumen Murrayae extract were all the fine powder of 90-500 mesh；
The Semen Strychni (processed) extract, safflower extract, Olibanum extract, Myrrha extract, Herba Asari extract, Radix Salviae Miltiorrhizae extract
Object, spikemoss extract, Folium Et Cacumen Murrayae extract are all using supercritical CO2Abstraction technique carries out supercritical CO2Fluid circulation extraction is received
Collection is made.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984089A (en) * | 2022-06-18 | 2022-09-02 | 张彩虹 | Preparation method of ointment for dredging collaterals, removing blood stasis and resolving masses |
-
2018
- 2018-08-30 CN CN201810994253.3A patent/CN108815268A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 周德生等: "《大剂量中药临床应用》", 30 September 2016, 山西科学技术出版社 * |
| 高学敏: "《中药学》", 31 March 2017, 中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984089A (en) * | 2022-06-18 | 2022-09-02 | 张彩虹 | Preparation method of ointment for dredging collaterals, removing blood stasis and resolving masses |
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Application publication date: 20181116 |