CN110721229A - A formula essential oil for treating mammary gland hyperplasia - Google Patents

Abstract

The invention discloses a formula essential oil for treating mammary gland hyperplasia. The present invention is composed of rose essential oil, peppermint essential oil, evening primrose essential oil, sweet orange essential oil and jojoba oil, and the peppermint essential oil is used as a penetration enhancer, and is absorbed through the skin. As an external medicine for treating mammary gland hyperplasia, the formula essential oil of the present invention greatly improves the comfort of use and avoids the disadvantages of oral medicine. In this clinical trial, the VAS score, lump size score, mass texture score, and TCM syndrome score of the Rose Menthol Essential Oil treatment group were significantly lower than those before treatment, and there were significant differences, indicating that Rose Mentha Soothing Essential Oil was effective in reducing breast pain. Pain, reducing breast lumps and improving lump texture and TCM symptoms have significant curative effects, and the total clinical efficacy rate is 100%, and the clinical curative effect is good.

Description

A formula essential oil for treating mammary gland hyperplasia

technical field

The invention relates to a formula essential oil for treating hyperplasia of mammary glands (rosemint soothing milk essential oil), which belongs to the field of medicine.

Background technique

Breast hyperplasia is a benign proliferative disease, because its pathogenesis is related to hormone levels, so the clinical cure rate is low, and the disease is easy to repeat. Traditional medicine believes that factors such as emotional insufficiency, deficiency of liver and kidney, disorder of Chong and Ren, mutual accumulation of phlegm and blood stasis will lead to the occurrence of mammary gland hyperplasia. The liver is the "official of the generals", which is good for evil and depression. Coagulation and disease. In addition, the kidney is the foundation of the innate, and it is mainly responsible for absorbing qi and water. If the kidney qi is deficient, it is easy to block the qi transformation of the body's zang-fu organs. Congestion and internal resistance, along the meridians, go against the breast, and develop breast addiction. From this point of view, mammary gland hyperplasia is mostly caused by liver stagnation and qi stagnation, poor circulation of qi and blood, and blood stasis blocking the meridians, and the knot becomes the nucleus. Modern science believes that breast hyperplasia is mostly related to factors such as qi stagnation, blood stasis, phlegm stasis, emotional discomfort, and endocrine disorders. In addition, mammary gland hyperplasia is also closely related to the decrease of progesterone secretion and the relative increase of estrogen.

Transdermal administration of traditional Chinese medicine is a commonly used therapy. Compared with other routes of administration, transdermal administration has the following advantages: ① It can avoid the degradation of the drug in the gastrointestinal tract and avoid the first pass effect of the liver; ② It can ensure the long-term release of the drug; Stable blood drug concentration; ④The administration is convenient and concise, and the administration can be terminated quickly if problems occur. The routes of transdermal administration of traditional Chinese medicine have various characteristics. For example, in the "True Biography of External Treatment of Traditional Chinese Medicine in Ancient and Modern Times", more than 50 routes such as sticking, compressing, bathing, showering, ironing, iontophoresis, and magnetic therapy are recorded.

Regarding the treatment of mammary gland hyperplasia by percutaneous administration of traditional Chinese medicine preparations, there are traditional Chinese medicine physiotherapy, traditional Chinese medicine acupoint sticking, traditional Chinese medicine sticking, traditional Chinese medicine external lotion and so on. For the external preparation used by Wang Yanxia, 3g of Angelica sinensis and 20g of Radix Paeoniae Alba were added to the formula, and water was added to boil it to a paste. Through the skin deep into the breast lesions, to achieve the purpose of promoting blood circulation and removing blood stasis, softening and dispelling knots, promoting qi and relieving pain (Wang Yanxia, Li Chunguang. Clinical observation of 312 cases of breast hyperplasia treated by external application of traditional Chinese medicine combined with physical therapy [J]. China Minkang Medicine , 2009,21(22):2824); Korean lotus uses rhubarb, Glauber's salt, Salvia miltiorrhiza, Bupleurum, etc., the Chinese medicine is pulverized and vinegar is added to prepare ointment, the ointment is heated and applied to the affected part of the breast, and after 2 courses of treatment , 90% of the patients stated that the ointment can effectively relieve the pain and discomfort of the breast (Korea Lian. Clinical observation of 43 cases of breast hyperplasia treated by external application of Chinese medicine for soothing the liver and regulating the spleen [J]. Journal of Chengde Medical College, 2015, 32(01) : 38-39); Yang Qiong selects An Ru Xiaotong Paste as the external medicine for the treatment of mammary gland hyperplasia, and the control group takes danazol orally, uses the patient of pain relief paste, breast pain is relieved, and the benign breast lump of some patients shrinks obviously, The levels of estradiol (E2) and prolactin (PRL) were significantly lower than those before treatment, and the clinical results were significantly better than those of the danazol group (Yangqiong. Anru Xiaotong paste on the clinical effect of kidney deficiency, Chong and Ren disorders on mammary gland hyperplasia). Observation [D]. Nanjing University of Traditional Chinese Medicine, 2015); Li Kejia's topical preparation for breast hyperplasia is traditional Chinese medicine Xiaozeng San, and the control group took Rupixiao orally. After clinical treatment, the curative effect of traditional Chinese medicine Xiaozeng San was 20.83% higher than that of the control group. %, the difference was significant (X2=8.574, P<0.05) (Li Kejia. Clinical effect of Xiaopi decoction combined with external application of traditional Chinese medicine in the treatment of 120 cases of breast hyperplasia [J]. Clinical Medicine Research and Practice, 2018, 3(19):128-129 ), so external preparations of traditional Chinese medicine can be used to relieve symptoms such as breast pain and discomfort and assist in the treatment of mammary gland hyperplasia.

SUMMARY OF THE INVENTION

The purpose of this invention is to provide a kind of formula essential oil for the treatment of mammary gland hyperplasia (rose and peppermint soothing milk essential oil), which is composed of rose essential oil, peppermint essential oil, evening primrose essential oil, sweet orange essential oil and jojoba oil, Peppermint essential oil is a penetration enhancer, which can be absorbed through the skin to treat mammary gland hyperplasia. It has the advantages of simple operation, short course of treatment, quick effect, and easy acceptance by women.

The technical scheme of the present invention is: a formula essential oil for treating hyperplasia of mammary glands, characterized in that the components and their parts by weight are: 25-35 parts of rose essential oil, 25-35 parts of peppermint essential oil, and 15-25 parts of evening primrose essential oil 5-15 parts of orange essential oil, 5-15 parts of jojoba oil.

Preferred ratio: 30 parts of rose essential oil, 30 parts of peppermint essential oil, 20 parts of evening primrose essential oil, 10 parts of sweet orange essential oil, and 10 parts of jojoba oil.

The above-mentioned essential oils can be commercially available essential oils, or can be made by methods such as steam distillation, and are uniformly mixed according to the above-mentioned proportions.

The solution of the present invention is as follows: the present invention uses peppermint essential oil and rose essential oil as the monarch medicine, and peppermint essential oil is used as a penetration enhancer, which can soothe the liver and activate qi, relieve pain and reduce swelling, and cooperate with rose essential oil to soothe the liver and relieve depression, promote blood circulation and dredging collaterals. , soothing emotions, diuresis and swelling; evening primrose essential oil, as a ministerial medicine, can promote blood circulation and remove blood stasis, and help relieve the symptoms of mammary gland hyperplasia; sweet orange essential oil, as an adjuvant, can soothe the liver and regulate qi, and use its smell to reconcile various medicines to enhance soothing Emotional effect; Jojoba oil, as a medicine, has good skin-friendly properties, can reconcile various essential oils, help lubricate the skin, and make the Rose Peppermint Soothing Cream better stick to the skin, so as to exert the maximum medicinal effect.

The raw materials and their functions are as follows:

Peppermint essential oil: Peppermint is taken from the stems and leaves and belongs to the Lamiaceae family. Traditional medicine believes that peppermint can disperse wind-heat, soothe the liver and activate qi, etc., and the application of peppermint in external preparations can well exert its medicinal effects. Peppermint essential oil has the characteristics of "aromatic walking" and is often used as a transdermal preparation. Literature studies have shown that peppermint essential oil, which is used as a penetration enhancer, can assist the absorption of components such as L-carnitine and levothyroxine. The main component of peppermint essential oil is menthol (also known as menthol). Menthol is a saturated cyclic terpene alcohol that can directly contact the skin and mucous membranes. Vasodilation, which plays a role in assisting drug penetration. In addition, peppermint essential oil also has strong anti-tumor activity, which can inhibit the growth of various tumor cells. The combination of peppermint essential oil and rose essential oil is used as the king medicine, which can exert the effect of "leading the group of medicines and reaching the hospital".

Rose essential oil: Rose is the flower of rose and double rose. Traditional medicine believes that rose has the functions of clearing away heat and detoxifying, soothing the liver and relieving depression, promoting blood circulation and dredging collaterals, regulating qi and regulating menstruation. Rose essential oil, which has been widely used now, is extracted from rose flowers. Rose essential oil mainly contains terpenes, alcohols, organic acids and other substances. Rose essential oil can help fight cancer, and citronellol and eugenol are its main components. In addition, Bulgarian scholars have found through research that rose essential oil has the effects of antibacterial and anti-inflammatory, stable emotions, and diuresis and swelling. The addition of rose essential oil in the formula can help soothe emotions, fight cancer, etc., and better exert the effect of the formula.

Evening primrose essential oil: Evening primrose, also known as evening primrose, is a perennial herb of the Willow family evening primrose. Traditional medicine believes that evening primrose has the effects of promoting blood circulation, removing blood stasis, promoting muscle and relieving pain. Clinical studies have found that the y-LA component in evening primrose essential oil is a component of the brain, muscle, bone marrow and cell membrane. In recent years, compounds such as lipophilic triterpenes and fatty acids have been isolated from evening primrose, which can inhibit plant growth and induce tumor cell apoptosis. Evening primrose essential oil is applied in the prescription, which can not only assist in anti-cancer, but also exert the effect of promoting blood circulation and removing blood stasis, and assisting in relieving the symptoms of breast hyperplasia.

Sweet orange essential oil: Traditional medicine believes that sweet orange is warm in nature and slightly bitter in taste. It can enter the lung, spleen, stomach, and liver meridians, and has the functions of clearing away heat and detoxifying, soothing the liver and regulating qi, resolving phlegm and producing fluid. Methyl-N-aminobenzoate is a typical aromatic component of Chinese sweet orange, and its main components are flavonoids, triterpenes and glyceroglycolipids. Studies have shown that the limonene component in sweet orange essential oil has the effect of calming the central nervous system, reducing mental stress and relieving emotional discomfort. Modern research has found that limonene can not only induce the activities of phase I and phase II detoxification enzymes, but also inhibit cancer genetic factor (v-Ha-ras). The application of sweet orange in the prescription not only takes its effect of soothing the liver and regulating qi, but also uses its smell to reconcile various medicines to enhance the effect of soothing emotions.

Jojoba Oil: Reconciling Medicines, Jojoba is an evergreen shrub of the Buxus family. Jojoba oil is the oil extracted from the seeds of this plant. The main component of jojoba oil is a monounsaturated substance, that is, there is only one double bond in each molecule, which makes jojoba oil have good skin-friendly properties. It can be added to the rose and peppermint soothing oil to reconcile various essential oils. Helps lubricate the skin, so that the rose and peppermint oil can better stick to the skin, so as to maximize the efficacy.

The beneficial effects of the invention are as follows: as an external medicine for treating mammary gland hyperplasia, the essential oil of rose peppermint soothing milk greatly improves the use comfort and avoids the drawbacks of oral medicine. In this clinical trial, the VAS score, lump size score, mass texture score, and TCM syndrome score of the Rose Menthol Essential Oil treatment group were significantly lower than those before treatment, and there were significant differences, indicating that Rose Mentha Soothing Essential Oil was effective in reducing breast pain. Pain, reducing breast lumps and improving lump texture and TCM symptoms have significant curative effects, and the total clinical efficacy rate is 100%, and the clinical curative effect is good.

Description of drawings

Figure 1 shows the transdermal absorption rate of the essential oil of rose peppermint soothing cream.

Detailed ways

Example 1:

Raw materials (parts by weight): 30 parts of rose essential oil, 30 parts of peppermint essential oil, 20 parts of evening primrose essential oil, 10 parts of sweet orange essential oil, 10 parts of jojoba oil, the above-mentioned raw materials are directly mixed in the above-mentioned proportions and used. The above-mentioned essential oils are all from Anhui Yinfeng Pharmaceutical Co., Ltd.

The following experimental data illustrate its effect:

1. Test purpose: To observe the clinical efficacy of rose peppermint essential oil in the treatment of breast pain and breast lumps related to mammary gland hyperplasia through a clinical randomized controlled trial, and to carry out transdermal absorption experiments to study the transdermal absorption of rose peppermint soothing essential oil. .

2. Test method:

2.1 Clinical trial: The included 120 patients with hyperplasia of mammary glands were randomly divided into a treatment group and a control group according to a ratio of 3:1, and were given Rose Peppermint Relief Essential Oil and placebo (jojoba oil plus a small amount of flavor enhancer) treatment, every day. The external application was rubbed twice for 28 consecutive days as a course of treatment, and the changes of clinical symptoms and signs of the patients were observed.

2.2 In vitro transdermal experiment: The essential oil of rose peppermint was administered locally by transdermal method, and the transdermal rate of rose peppermint essential oil was determined by gas chromatography on the isolated mouse skin to verify the transdermal absorption of rose peppermint soothing essential oil. effect.

3. Clinical data

3.1 General information of patients

3.1.1 Age comparison of the two groups of patients

In the treatment group, the minimum age of the patients was 18 years old, the maximum age was 52 years old, and the average age was 30.06 ± 8.10 years old; in the control group, the minimum age of the patients was 21 years old, and the maximum age was 47 years old, with an average age of 30.63 ± 7.89 years old. Two groups P=0.734>0.05 (P>0.05). There was no significant difference in age between the two groups, that is, there was no statistical difference (P>0.05). The two groups can be compared, see Table 1 for details.

Table 1 Age comparison of the two groups of patients

3.1.2 Comparison of the course of disease between the two groups of patients

The course of the disease in both groups ranged from 1 to 10 years. The average disease course of the treatment group was 3.18±2.30 years; the average disease course of the control group was 3.33±2.25 years, P=0.748>0.05 (P>0.05). There was no significant difference in the course of disease between the two groups, which can be compared, see Table 2 for details.

Table 2 Comparison of disease course of patients

3.1.3 Comparison of clinical symptoms between the two groups of patients before treatment

Average breast pain score: 3.53±1.80 in the treatment group and 3.60±1.75 in the control group; breast lump size score: 0.20±0.52 in the treatment group and 0.27±0.69 in the control group; breast lump texture score: 0.22±0.58 in the treatment group and 0.22±0.58 in the control group 0.20±0.48; TCM symptom score: 9.06±4.64 in the treatment group and 8.93±5.29 in the control group; there was no significant difference in clinical symptoms between the two groups before treatment, and the two groups can be compared, see Table 3.

Table 3 Comparison of clinical symptoms of two groups of patients before treatment

3 Efficacy criteria

3.1 Criteria for judging the severity of the disease

With reference to the eighth meeting of the Breast Disease Professional Committee of the Chinese Society of Traditional Chinese Medicine Surgery in 2002, the breast lump size, lump texture and TCM symptom grading were formulated; breast pain was scored using the recognized VAS pain scale, and the lump size, mass texture and TCM symptom scores were scored. Based on the instructor's experience.

3.1.1 Breast VAS Pain Scale

The generally accepted VAS pain scale is used: 0 points for no pain, 10 points for extreme pain, 1-3 points for mild pain, 4-6 points for the patient's pain that affects sleep and can be tolerated, and 7-10 points for the patient's severe pain The pain is unbearable, affecting appetite and sleep. Scored by physicians at the corresponding scale.

3.1.2 Scoring criteria for breast lump size

Referring to the eighth meeting of the Breast Disease Professional Committee of the Chinese Society of Traditional Chinese Medicine Surgery in 2002, it was formulated: 0 points for no mass, 1 point for lumps with a length of ≤1cm, 2 points for a tumor with a length of >1cm, ≤2cm, 3 points for a tumor with a length of more than 2cm, ≤ 3cm. Ultrasonography examines the condition of breast lumps, accurately measures the length and diameter of the lumps, and scores the corresponding grades by the physician.

3.1.3 Scoring criteria for texture of breast lumps

Referring to the eighth meeting of the Breast Disease Professional Committee of the Chinese Society of Traditional Chinese Medicine Surgery in 2002, it was formulated: 0 points for no lumps, 1 points for lumps as soft as normal glands, 2 points as tough as the tip of the nose, and 3 points as hard as foreheads. Palpation by a professional physician, and graded by the physician at the corresponding level.

3.1.4 Criteria for determining TCM symptoms

TCM symptoms are divided into hot and sweating, soreness and weakness of waist and knees, fatigue, irritability, insomnia, dizziness, tinnitus, upset and bitter mouth, menstrual disorders, chest and flank pain. Grade 0 is scored as 0 points, asymptomatic; Grade 1 is scored as 1 point, with occasional symptoms; Grade 2 is scored as 2 points, with obvious symptoms but can be relieved; After the patient describes his symptoms, the physician makes a judgment based on the patient's own situation, and the physician scores at the corresponding level.

3.2 Criteria for determining clinical efficacy

According to the "Guidelines for Clinical Research on New Chinese Medicine Treatment", the clinical efficacy is determined. Efficacy index (n)=[(integration before treatment-integration after treatment)/integration before treatment]×100%.

①Cure: n≥90%;

②Significantly effective: 75%≤n＜90%;

③ Effective: 30%≤n＜75%;

④Invalid: n<30%.

3.3 Evaluation criteria for the efficacy of TCM symptoms

According to the "Guidelines for Clinical Research on New Drug Treatment of Traditional Chinese Medicine", the criteria for judging the efficacy of traditional Chinese medicine symptoms are as follows:

①Cure: After treatment, the clinical symptoms of traditional Chinese medicine disappeared, and the score was 0;

②Significantly effective: After treatment, the clinical symptoms of traditional Chinese medicine were significantly improved, and the score was reduced by two grades;

③ Effective: the clinical symptoms of TCM improved after treatment, and the score decreased by one grade;

④Invalid: After treatment, the clinical symptoms of TCM did not change significantly or aggravated, and the score did not change or the score level increased.

3.2 Analysis of clinical efficacy

3.2.1 Comparison of VAS scores between the two groups after treatment

The VAS scores of the two groups of patients after treatment, compared with the control group, the treatment group is significantly better than the control group; Pain was effective; in the control group, P=0.103>0.05, there was no significant difference in the data before and after treatment, and the difference was not statistically significant, and the treatment was ineffective. See Table 4.

Table 4 Comparison of VAS scores between the two groups of patients after treatment

3.2.2 Comparison of breast lump size between two groups of patients after treatment

The breast lump size scores of the two groups of patients after treatment, the treatment group compared with the control group, the treatment group decreased. The curative effect of breast lumps was significantly better than that of the control group; the treatment group P=0.007<0.05, the data before and after treatment had significant difference, and the pain treatment was effective; the control group P=0.326>0.05, there was no significant difference before and after treatment, and the treatment was ineffective. See Table 5.

Table 5 Comparison of breast lump size between two groups of patients after treatment

3.2.3 Comparison of breast mass texture between two groups of patients after treatment

After the treatment of the two groups of patients, compared with the control group, the curative effect of the treatment group in improving the texture of the mass was significantly better than that of the control group; the treatment group P=0.000<0.05, there was a significant difference in the data before and after the treatment, and it had a significant curative effect on improving the texture of the mass. , the control group P=0.326>0.05, there is no significant difference in the data before and after treatment, it is ineffective for improving the texture of the mass, see Table 6.

Table 6 Comparison of mass texture in two groups of patients after treatment

3.2.4 Comparison of TCM symptoms in the two groups after treatment

After the treatment of the two groups of patients, compared with the control group, the therapeutic effect of the treatment group in improving TCM symptoms was significantly better than that of the control group; the treatment group P=0.00<0.05, the data before and after treatment were significantly different, indicating that the improvement of TCM symptoms was effective; the control group P=0.083>0.05, there is no significant difference in the data before and after treatment, indicating that it is ineffective to improve TCM symptoms, see Table 7.

Table 7 Comparison of TCM symptoms in the two groups of patients before and after treatment

3.2.5 Evaluation of the clinical efficacy of the two groups of patients after treatment

Comparison of clinical efficacy before and after treatment in the two groups, using X ² test, X ² =43.83, P = 0.00﹤0.05, the difference was statistically significant, and the total effective rate of clinical efficacy in the treatment group was 100%, which was significantly higher than that in the control group. group treatment was effective. See Table 8.

Table 8 Clinical efficacy of two groups of patients before and after treatment

3.2.6 Evaluation of the efficacy of TCM symptoms in the two groups of patients after treatment

Comparing the efficacy of TCM symptoms before and after treatment in the two groups, the effective rate in the treatment group was significantly higher than that in the control group, using the X ² test, P=0.00﹤0.05, the difference in the effective rate between the two groups was statistically significant, and the treatment group was effective in improving TCM symptoms. See Table 9.

Table 9 The efficacy of TCM symptoms after treatment in the two groups of patients

3.3 Drug eruption

Comparison of the drug eruption after treatment in the two groups, using the X ² test, X ² =0.678, P = 0.439>0.05, the difference was not statistically significant, there was no significant difference in the incidence of drug eruption between the two groups, that is, the treatment group The incidence of drug eruption was lower in the control group and the control group, as shown in Table 10.

Table 10 Comparison of drug eruption after treatment in two groups of patients

3.4 Other adverse reactions

During the treatment period, one patient in the treatment group and one in the control group developed drug eruption. The drug eruption patients in the control group had allergic constitution, and the allergic patients in the two groups disappeared spontaneously after drug withdrawal. Except for drug eruption in individual patients, there were no adverse reactions in other patients in the two groups.

3.5 Transdermal absorption results

Table 11. Transdermal absorption rate of essential oil of rose peppermint soothing cream

The results showed that the cumulative penetration rate of rose mint essential oil increased gradually within 6 hours, and the maximum cumulative transdermal absorption rate was 39.86%. The cumulative permeation of the essential oil of rose and peppermint in 1 hour gradually increased and the growth rate was fast, indicating that the essential oil of rose and peppermint can exert its medicinal effect within 1 hour, and the medicinal effect can be continuously exerted within 6 hours, which can achieve a better curative effect.

4 Results Analysis

(1) The VAS score showed that after comparing the two groups of patients before and after treatment, the treatment group P=0.00<0.05, indicating that the rose and peppermint essential oil was effective in treating pain; the control group P=0.103>0.05, the placebo was ineffective in treating pain.

(2) The results of tumor size score showed that after comparing the two groups of patients before and after treatment, the treatment group P=0.007＜0.05, indicating that the rose and peppermint soothing essential oil was effective in reducing breast lumps; the control group P=0.326>0.05, the placebo was ineffective in reducing breast lumps .

(3) The results of the mass texture score showed that after the comparison between the two groups before and after treatment, the treatment group P=0.000<0.05, indicating that the rose peppermint essential oil was effective in improving the mass texture; the control group P=0.326>0.05, the placebo was ineffective in improving the mass texture .

(4) The results of TCM symptom score showed that after comparing the two groups of patients before and after treatment, the treatment group P=0.000<0.05, indicating that the essential oil of rose and peppermint is effective in improving TCM symptoms; the control group P=0.083>0.05, the placebo improves TCM symptoms invalid.

(5) The clinical efficacy results showed that the total effective rate was 100% in the treatment group and 10% in the control group. Using the X ² test, X ² =43.83, P=0.000﹤0.05, there was a significant difference in the total effective rate between the two groups , and the total effective rate in the treatment group was significantly higher than that in the control group.

(6) X ² test was used for the efficacy of traditional Chinese medicine symptoms, X ² =105.043, P = 0.000﹤0.05, the difference in effective rate between the two groups was significant, and the effective rate in the treatment group was significantly higher than that in the control group.

(7) During the treatment period, one patient in the treatment group and one in the control group developed a drug eruption, and the allergic patients in the two groups disappeared spontaneously after the drug was discontinued. Except for drug eruption, there were no other adverse reactions in the two groups.

(8) The transdermal absorption experiment proves that the effective time of the essential oil is 5-6h, and the drug is accumulated and released with the prolongation of time. After 6 hours of the experiment, the skin penetration rate of menthol in the drug exceeded 39.86%, indicating that the active ingredients in the essential oil of rose and peppermint soothing milk are easy to penetrate the skin and can play a better therapeutic role.

Claims (2)

1. The formula essential oil for treating hyperplasia of mammary glands is characterized by comprising the following components in parts by weight: 25-35 parts of rose essential oil, 25-35 parts of mint essential oil, 15-25 parts of evening primrose essential oil, 5-15 parts of sweet orange essential oil and 5-15 parts of jojoba oil.

2. The essential oil for treating hyperplasia of mammary glands according to claim 1, wherein the essential oil comprises the following components in parts by weight: 30 parts of rose essential oil, 30 parts of mint essential oil, 20 parts of evening primrose essential oil, 10 parts of sweet orange essential oil and 10 parts of jojoba oil.