CN104971209A - Externally used agent for treating tinea pedis and preparation method thereof - Google Patents

Externally used agent for treating tinea pedis and preparation method thereof Download PDF

Info

Publication number
CN104971209A
CN104971209A CN 201510435435 CN201510435435A CN104971209A CN 104971209 A CN104971209 A CN 104971209A CN 201510435435 CN201510435435 CN 201510435435 CN 201510435435 A CN201510435435 A CN 201510435435A CN 104971209 A CN104971209 A CN 104971209A
Authority
CN
Grant status
Application
Patent type
Prior art keywords
parts
step
treatment
tinea pedis
external preparation
Prior art date
Application number
CN 201510435435
Other languages
Chinese (zh)
Inventor
郝莉
Original Assignee
郝莉
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

The invention discloses an externally used agent for treating tinea pedis and a preparation method thereof. The agent is prepared from the following main active pharmaceutical ingredients in parts by weight: 9-15 parts of morinda root, 11-16 parts of garden euphorbia herb, 8-17 parts of herb of white loosestrife, 9-12 parts of mountain dragon, 7-14 parts of falsehellebore root and rhizome, 6-12 parts of seed-coat of broadbean, 9-13 parts of twig and leaf of orangeeye butterflybush, 8-12 parts of root of redfruit actionodaphne, 10-16 parts of castor leaf, 9-17 parts of common achyranthes herb, 7-15 parts of fortune eupatorium herb,11-17 parts of leaf of betel pepper, 9-14 parts of roylean euphorbia and 11-18 parts of lily. The agent has the good effects of no trauma, no pain, no toxic or side effect, treatment of both symptoms and root causes, high cure rate, low possibility of relapse after cure and low treatment cost.

Description

治疗足癣的外用剂及其制备方法 Topical and preparation method of treating tinea pedis

技术领域 FIELD

[0001] 本发明涉及中医中药领域,特别是涉及一种治疗足癣的外用剂及其制备方法。 [0001] The present invention relates to the field of Chinese medicine, particularly, to an external preparation and a preparation method for the treatment of tinea pedis.

背景技术 Background technique

[0002] 足癣系真菌感染引起,其皮肤损害往往是先单侧(即单脚)发生,数周或数月后才感染到对侧。 [0002] Department of athlete's foot fungal infection, skin damage is often their first one-sided (ie foot) occur weeks or months after infection to the opposite side. 水疱主要出现在趾腹和趾侧,最常见于三四趾间,足底亦可出现,为深在性小水疱,可逐渐融合成大疱。 Mainly in the abdominal blisters toe and the toe side, the most common in thirty-four toes, plantar may occur in deep small blisters, it can be gradually integrated into the bulla. 足癣的皮肤损害有一特点,即边界清楚,可逐渐向外扩展。 Tinea pedis skin lesions have a characteristic that a clear boundary may gradually spread. 因病情发展或搔抓,可出现糜烂、渗液,甚或细菌感染,出现脓疱等。 Due to progression of the disease or scratching, there may be erosion, exudate, or even bacterial infections, pustules and so on. 足癣是由致病性真菌引起的足部皮肤病,具有传染性。 Athlete's foot is the foot skin disease caused by pathogenic fungi, is contagious. 足癣在全世界广为流行,在热带和亚热带地区更为普遍。 Athlete's foot is widely popular in the world, is more common in tropical and subtropical regions. 在我国, 足癣的发病率也相当高。 In China, the incidence of tinea pedis is quite high. 人的足底和趾间没有皮脂腺,从而缺乏抑制皮肤丝状真菌的脂肪酸,生理防御机能较差,而这些部位的皮肤汗腺却很丰富,出汗比较多,加之空气流通性差、 局部潮湿温暖,有利于丝状真菌的生长。 No human plantar and interdigital sebaceous glands, thereby inhibiting skin filamentous fungi lack of fatty acids, poor physiological defense mechanisms, these parts of the skin is very rich in sweat glands, sweat more, combined with poor air circulation, local warm and humid, It is conducive to the growth of filamentous fungi. 此外,足底部位皮肤角质层较厚,角质层中的角蛋白是真菌的丰富营养物质,有利于真菌的生长。 In addition, parts of the skin foot thick cuticle, keratin cuticle is the fungus is rich in nutrients, is conducive to the growth of fungi. 妇女在妊娠期间,由于内分泌的变化,引起皮肤抵抗真菌感染的能力下降,易患足癣。 Women during pregnancy, due to changes in endocrine, reduced ability to cause skin against fungal infection, susceptible to athlete's foot. 肥胖者因趾间潮湿,汗液浸渍易患足癣。 Obesity due to moisture between the toes, sweat soaking susceptible tinea pedis. 足部皮肤受外伤,破坏了皮肤的防御功能,也是诱发足癣的因素之一。 Foot skin affected by trauma, damage skin's defenses, but also one of the factors inducing tinea pedis. 糖尿病患者由于缺乏胰岛素导致物质代谢紊乱,皮肤含糖量增加导致抵抗力下降,也易患足癣。 Patients with diabetes due to a lack of insulin leads to metabolism disorders, skin sugar content increases lead to decreased immunity, also susceptible to athlete's foot. 滥用抗生素,长期使用皮质类固醇激素和免疫抑制剂等,使皮肤正常菌群失调,也会增加足癣的易感性。 Misuse of antibiotics, long-term use of corticosteroids and immunosuppressive agents, etc., make the skin normal flora, will increase the susceptibility of athlete's foot. 足癣的发病还与生活习惯有关。 The incidence of tinea pedis also related to lifestyle. 有些人不注意足部清洁卫生和鞋袜的情况,为真菌提供了良好的孳生场所。 Some people do not pay attention to hygiene situation of the foot and footwear, providing a good breeding place for fungus.

[0003] 临床表现为脚趾间起水疱、脱皮或皮肤发白湿软,也可出现糜烂或皮肤增厚、粗糙、开裂,并可蔓延至足跖及边缘,剧痒。 [0003] The clinical manifestations between the toes blisters, peeling skin or pale squishy, ​​also appear erosion or skin thickening, rough, cracked, and can spread to the plantar edge, is itching. 可伴局部化脓、红肿、疼痛,腹股沟淋巴结肿大,甚至形成小腿丹毒及蜂窝组织炎等继发感染。 May be associated with local purulent, swelling, pain, inguinal lymph nodes, even the formation of the leg and other secondary infection erysipelas and cellulitis. 由于用手抓痒处,常传染至手而发生手癣(鹅掌风)。 Since the hand scratching, ringworm (Liriodendron wind) infection often occurs to the hand. 真菌在指(趾)甲上生长,则成甲癣(灰指甲)。 Fungus on a finger (toe) growth into the onychomycosis (nail fungus). 真菌喜爱潮湿温暖的环境,夏季天热多汗,穿胶鞋、尼龙袜者更是为真菌提供了温床;冬季病情多好转,表现为皮肤开裂。 Fungi love moist warm environment, hot summer days sweating, wear rubber boots, nylon stockings were but also provides a breeding ground for fungus; winter condition improved and more, manifested as skin cracking. 有以下几种类型:1.水疱型:多发生在夏季,表现为趾间、足缘、足底出现米粒大小,深在性水疱,疏散或成群分布,疱壁较厚,内容清澈,不易破裂,相互融合形成多房性水疱,撕去疱壁,可见蜂窝状基底及鲜红色糜烂面,剧烈瘙痒。 There are several types: 1 Vesicular: occur in the summer, the performance and toes foot edge, foot size of grain of rice, deep in blisters, evacuation or distributed in groups, thick-walled blisters, content is clear, easy to rupture, each fused to form a multi-room blisters, blister wall torn, and bright red visible honeycomb substrate surface erosion, intense itching. 2.糜烂型:表现为局部表皮角质层浸软发白。 2. erosive: the performance of local stratum corneum macerated white. 由于走动时不断摩擦表皮脱落,露出鲜红色糜烂面;严重者趾缝间、趾腹与足底交界处皮肤均可累及,瘙痒剧烈,多发于第3、4、5趾缝间。 Since the constant friction when walking excoriation, bright red erosion surface is exposed; sutural severe toe, toe and foot junction of the abdominal skin may be involved, itching, mainly in the toe sutural 3,4,5. 常见于多汗者。 Common in hyperhidrosis. 3.鳞肩角化型:症状是足跖、 足缘、足跟部皮肤脚趾增厚、粗糙、脱肩,鳞肩成片状或小点状,反复脱落。 3. Shoulder keratotic scales: symptom is paw, foot edge, heel toe skin thickening, rough, off the shoulder, shoulder scales into a sheet or a small dot, off repeatedly.

[0004] 治疗:1.趾间有糜烂、渗液者不可以外用刺激性强的药,最好先使创面收敛干燥再用药。 [0004] Treatment: 1. interdigital erosion, exudate not strong irritant topical drug, preferably first dried and then wound convergence medication. 可以用I :8000高锰酸钾溶液湿敷,然后外用油剂或粉剂,待皮肤干燥后改用盐酸特比萘芬等霜剂或软膏。 May be I: 8000 wet potassium permanganate solution, and then oil or external powders, dry skin until use terbinafine hydrochloride cream or ointment and the like. 2.如果皮肤角化增厚严重,抗真菌药物很难渗透吸收,可以先用10%水杨酸软膏或复方苯甲酸软膏等使角质软化,再用抗真菌药。 2. If severe thickening of skin keratinocytes, antifungal difficult to penetrate the absorbent beforehand with 10% salicylic acid ointment ointment or the like compound to soften the skin, and then antifungal agents. 皮肤干裂明显者,可以每次温水浸泡,使角质软化,再用抗真菌药。 Obvious dry skin, warm water can each make keratolytic, antifungal reuse. 皮肤干裂明显者,可以每次温水浸泡后局部涂油膏,然后用塑料薄膜封包,外缠绷带,24~48小时后除去,然后再用抗真菌药。 Obvious dry skin, can after each topical salve soaked in warm water, and then the packet with plastic film, the outer bandage was removed after 24 to 48 hours, and then use the antifungal. 3.足部起小水疱,未破溃者,可以先用3%硼酸溶液浸泡,然后选用联苯苄唑乳膏等抗真菌霜剂。 3. foot from a small blisters, ulceration is not to be first soaked with 3% boric acid solution, and then choose the cream bifonazole antifungal creams and the like. 4.足癣合并细菌感染,原则上应先局部抗细菌感染,可以用呋喃西林溶液或I :2000黄连素溶液湿敷,严重感染者,可以口服抗生素,如头孢氨苄胶囊、红霉素等。 4. pedis bacterial infection, topical anti-bacterial infection should in principle, may be a solution or nitrofurazone I: 2000 berberine wet solution, severe infections, antibiotics can be administered orally, such as capsules cephalexin, erythromycin. 5.全身治疗。 5. systemic therapy. 对于顽固的足癣,在没有禁忌证的情况下,可以给予口服药。 For stubborn athlete's foot, in the absence of contraindications cases, oral medication may be given. 如特比萘芬、伊曲康唑、氟康唑等。 Such as terbinafine, itraconazole, fluconazole and the like. 这些口服药物效果好,但应注意其可能带来的副反应,肝功能不良者忌用。 These oral medications effective, but should pay attention to its possible side effects, liver dysfunction were hanged. 6.要坚持用药。 6. To adhere to medication. 足癣是一种慢性感染,真菌寄生角质层中生长繁殖,需长期用药才能彻底去除。 Tinea pedis is a chronic infection, fungal growth and reproduction of parasitic stratum corneum, need long-term medication can be completely removed. 因此,足癣的症状缓解后,仍需坚持用药,皮肤的代谢周期为28天左右,用药时间一定要坚持四周以上。 Therefore, the symptoms of athlete's foot, still need to adhere to medication, skin metabolic cycle is about 28 days, time of administration must adhere to more than four weeks. 最好进行真菌检查及培养,连续三星期都是阴性才算治愈。 Best for mycology and culture, continuous three weeks were negative be considered cured. 7.不要乱用药。 7. Do not abuse drugs. 足癣用药最关键的是应按照分型进行连贯正规的治疗。 The key is athlete's foot medication should be consistent regular treatment in accordance with the classification. 8.用药要根据病变的具体情况。 8. The medication according to the specific circumstances of the lesion. 破溃处不能用酊剂,皮肤变厚,裂口应该用软膏。 Ulceration can not use tinctures, skin thickening, cracks it should ointment. 9.足癣发生继发感染时,局部出现急性炎症就不能按一般足癣治疗,应该先处理继发感染。 9. pedis secondary infection occurred can not be localized acute inflammation as a general treatment of tinea pedis, should be processed first secondary infection. 如有红肿,局部可外用硼酸水或呋喃西林液冷温敷,必要时还要全身应用抗生素,并按照医生嘱咐适当休息。 If redness, local or topical boric acid water was cooled nitrofurazone warm dressing, systemic antibiotics also, if necessary, and in accordance with the doctor ordered proper rest.

[0005] 申请公布号CN 103705585 A (申请号201310678500. 6)的中国专利文献公开了一种治疗足癣的中药,其特征在于原料药按质量份数计为:苦参25-35份、白矾25-35份、 千里光15-25份、地肤子20-25份、蛇床子25-35份、枯矾15-30份、五倍子15-25份。 [0005] Application Publication No. CN 103705585 A (Application No. 201310678500.6) of Chinese medicine patent discloses a method of treating tinea pedis, characterized in that the mass fraction of the total drug is: Sophora 25-35 parts, alum 25-35 parts, Senecio 15-25 parts, 20-25 parts Kochia scoparia, Cnidium 25-35 parts, 15-30 parts of alum, gallic 15-25 parts. 申请公布号CN 104147434 A (申请号201410333708. 9)的中国专利文献公开了一种治疗足癣的中药洗剂,所述的中药洗剂是通过以下方法制备的:按重量份取透骨草20-30份、米仁20-30份、大蒜5-10份、厚朴30-40份、艾叶30-40份、枇杷叶30-40份、苦参20-30份、败酱草20-30份、蒲公英10-20份、黄芩10-20份、青皮10-20份,煎煮即得。 Application Publication No. CN 104147434 A (Application No. 201410333708.9) of Chinese herbal lotion patent document discloses a method of treating tinea pedis, the herbal lotion is prepared by the following process: parts by weight 20 taken lopseed -30 copies, MI Ren 20 to 30 parts, 5-10 parts garlic, Magnolia 30-40, 30-40 leaves, leaves 30-40, 20-30 Sophora part, Patrina 20-30 parts, 10-20 parts of dandelion, scutellaria 10-20 parts, 10-20 parts peel, i.e., boiling too. 申请公布号CN 104288632 A (申请号201410471574. 7)的中国专利文献公开了一种用于治疗角化过度型足癣的药物制剂,其原料药包括皂角刺、藁本、藿香、苍耳子、首乌藤、白芷、牡荆叶、大蒜、苦楝皮、苦参、菝葜、黄精、白屈菜、白鲜皮、艾叶、山豆根、芦荟、川楝子、土荆皮、百部、地肤子、 猫爪草、威灵仙和菊花。 Application Publication No. CN 104288632 A (Application No. 201410471574.7) of the Chinese patent document discloses a pharmaceutical formulation for the treatment of hyperkeratotic type tinea pedis which comprises a drug stings, Ligusticum, rugosa, Xanthium son, Polygonum vine, Angelica, Vitex leaf, garlic, neem bark, Sophora, sarsaparilla, Huang Jing, celandine, fresh white skin, leaves, Shandougen, aloe vera, Toosendan, pseudolaric hundred Ministry of belvedere fruit, Maozhaocao, clematis and chrysanthemums.

[0006] 目前,市场上治疗足癣的药物品种繁多,但是大多存在着有效率低,复发率高,副作用大,价格较贵等缺点。 [0006] Currently, the market wide variety of drugs in the treatment of athlete's foot, but mostly there is low efficiency, high recurrence rate, side effects, expensive and other shortcomings. 因此,研制出一种经济、疗效显著的治疗足癣的药物是必要的。 Therefore, developed an economy, a significant effect of treatment of athlete's foot medication is necessary.

发明内容 SUMMARY

[0007] 针对现有技术的不足,本发明的目的是提供一种治疗足癣的外用剂及其制备方法。 [0007] for the deficiencies of the prior art, an object of the present invention is to provide a method of treating tinea pedis topical preparation method thereof. 本发明无创伤、无痛苦、无毒副作用,标本兼治,治愈率高,愈后不易复发,治疗费用低廉。 The present invention is non-invasive, painless, non-toxic side effects, treating the symptoms, high cure rate, less recurrence after healing, a low treatment cost.

[0008] 本发明的技术方案是: 治疗足癣的外用剂,取下述重量配比的主要原料药制备而成:巴戟天9-15,大飞扬草11-16,单条草8-17,古山龙9-12,藜芦7-14,蚕豆壳6-12,酒药花9-13,红果楠8-12,蓖麻叶10-16,倒扣草9-17,佩兰7-15,筠酱叶11-17,霸王鞭9-14,百合11-18。 [0008] The aspect of the present invention is: Topical agents for the treatment of tinea pedis, prepared by taking the ratio by weight of the main drug from: Morinda 9-15, 11-16 Euphorbia hirta large, single grass 8-17 ancient mountain dragon 9-12, hellebore 7-14, shell beans 6-12, 9-13 Jiuyao flowers, red berries Nan 8-12, 10-16 castor leaves, grass upside down 9-17, 7-15 Perrin , Jun Ye 11-17 sauce, rattle 9-14, 11-18 lily.

[0009] 治疗足癣的外用剂,优选的方案是,取下述重量配比的主要原料药制备而成:巴戟天11-13,大飞扬草12-14,单条草10-15,古山龙10-11,藜芦9-13,蚕豆壳8-11,酒药花10-12,红果楠9-11,蓖麻叶12-14,倒扣草11-15,佩兰10-13,筠酱叶12-15,霸王鞭11-13, 百合12-16。 [0009] Topical agents for the treatment of tinea pedis, the preferred embodiment is prepared by taking the following weight proportions of the main drug: Morinda 11-13, 12-14 Euphorbia hirta large, single 10-15 grass, gushan Long 10-11, 9-13 hellebore, shell beans 8-11, 10-12 Jiuyao flower, red Nan 9-11, 12-14 castor leaves, grass upside down 11-15, 10-13 Perrin, Yun butter leaf 12-15, rattle 11-13, 12-16 lily.

[0010] 治疗足癣的外用剂,更加优选的方案是,取下述重量配比的主要原料药制备而成: 巴戟天12,大飞扬草13,单条草13,古山龙10. 5,藜芦11,蚕豆壳9,酒药花11,红果楠10, 蓖麻叶13,倒扣草12,佩兰12,筠酱叶14,霸王鞭12,百合15。 [0010] Topical agents for the treatment of tinea pedis, more preferred embodiment, the weight ratio prepared by taking the following main drug: Morinda 12, large Euphorbia hirta 13, 13 grass single, long gushan 10.5, hellebore 11, broad bean shells 9, 11 Jiuyao flowers, red Nan, 10, 13 castor leaves, grass upside down 12, 12 Perrin, 14 Jun sauce leaf, rattle 12, lily 15.

[0011] 上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入6. 8-8. 4倍量水,先用武火煎煮,沸后转文火煮32-46分钟,滤出药液,浓缩成60°C下相对密度为1. 27-1. 32的药膏; (2) 将酒药花放入沸水中,加盖,浸泡3-5小时后捞出沥干,然后晒干,研成细粉,过150 目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/5-3/5的凡士林,调勾,即得。 [0011] The method of preparing the above-described external agents for treatment of tinea pedis are: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, add 6 8-84 times the amount of water. , first Wuhuo boiling, boiling after turn Simmer 32-46 minutes, the liquid was filtered, concentrated to the relative density of 1. 27-132 of 60 ° C for ointments;. (2) into the flower Jiuyao boiling water, cover, remove and drain after soaking 3-5 hours, then dried, and research into a fine powder, over 150 mesh sieve; (3) in addition to the large Euphorbia hirta, ancient mountain dragon, hellebore, flower Jiuyao, 8 taste drug castor outer leaves and rattle were fine, through 150 mesh sieve; (4) the mix of step (1), step (2) and step (3), is added in step (1), the step ( 2) and step (3) by total weight of petrolatum 1 / 5-3 / 5, the transfer hook, that is, too.

[0012] 优选在于步骤(1)中,加入7. 5-8. 2倍量水。 [0012] Preferably wherein the step (1), and 7. 5-8. 2-fold amount of water.

[0013]优选在于步骤(1)中,沸后转文火煮35-42分钟。 [0013] Preferably wherein the step (1). After boiling turn Simmer 35-42 minutes.

[0014]优选在于步骤(1)中,浓缩成60°C下相对密度为1. 29-1. 31的药膏。 [0014] Preferably wherein the step (1), and concentrated to a relative density of 1. 29-1. 31 to 60 ° C for ointments.

[0015]优选在于步骤(2)中,浸泡3. 2-4. 6小时后捞出沥干。 [0015] Preferably wherein the step (2), after soaking 3. 2-4. 6 hours remove and drain.

[0016]优选在于步骤(4)中,加入步骤(1)、步骤(2)和步骤(3)所得总重量1/4-1/2的凡士林。 [0016] wherein preferably in step (4) was added in step (1), the resulting total weight of petrolatum in step (2) and (3) 1 / 4-1 / 2.

[0017] 更加优选的,步骤(1)中加入7. 8倍量水。 [0017] More preferably, the step of adding 7.8 times the amount of water (1).

[0018] 更加优选的,步骤(1)中沸后转文火煮37分钟。 [0018] More preferably, after the step (1) boiling in turn Simmer 37 minutes.

[0019] 更加优选的,步骤(1)中浓缩成60°C下相对密度为1. 3的药膏。 [0019] More preferably, the concentration step to a relative density of 1.3 to 60 ° C for creams (1).

[0020] 更加优选的,步骤(2)中浸泡3. 8小时后捞出沥干。 [0020] More preferably, remove and drain after the step (2) immersed in 3.8 hours.

[0021] 更加优选的,步骤(4)中加入步骤(1)、步骤(2)和步骤(3)所得总重量1/3的凡士林。 [0021] More preferably, in step (4) was added in step (1), Step (2) and (3) the total weight of the resulting 1/3 petrolatum.

[0022] 本发明提供的治疗足癣的外用剂组方科学合理。 [0022] The present invention provides topical treatment of tinea pedis enhancers of scientific and rational. 除此之外,本发明的优良效果还表现在: 1、 无创伤、无痛苦、无毒副作用; 2、 具有燥湿止痒、清热解毒、祛风除湿、杀虫止痒、泻火解毒、消肿止痛之功效, 最终达到治愈足癣的目的; 3、 标本兼治,治愈率高,愈后不易复发; 4、 治疗费用低廉; 5、 制备方法简单; 6、 使用简便,不影响生活和学习。 In addition, excellent effects in the present invention also exhibit: 1, non-invasive, painless, toxic side effects; 2, with dampness antipruritic, detoxification, Qufengchushi, insecticidal itching, purging fire detoxification, the effect of swelling and pain, and ultimately achieve the purpose of cure athlete's foot; 3, treating the symptoms, high cure rate, recurrence after healing; 4, low cost of treatment; 5, simple preparation method; 6, easy to use, does not affect the life and learning .

具体实施方式 Detailed ways

[0023] 下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不限于此。 [0023] The following Examples and Experimental Examples illustrate the technical details of the present invention, but the scope of protection is not limited thereto.

[0024] 实施例1治疗足癣的外用剂,取下述重量份的主要原料药制备而成(每份为700g): 巴戟天9份,大飞扬草11份,单条草8份,古山龙9份,藜芦7份,蚕豆壳6份,酒药花9份, 红果楠8份,蓖麻叶10份,倒扣草9份,佩兰7份,筠酱叶11份,霸王鞭9份,百合11份。 [0024] Example 1 Treatment of tinea pedis external preparation, prepared from (to 700 g of each) taken parts by weight of the main raw material of the following drugs: Morinda 9 parts, 11 parts of a large Euphorbia hirta, 8 parts of a single grass, gushan Long nine, hellebore seven, six shell beans, Jiuyao spend nine, red Nan 8 parts, 10 parts of castor leaves, grass upside down nine, Perrin 7 parts, 11 parts butter Yun Ye, rattle nine lily 11 copies.

[0025] 上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入6. 8倍量水,先用武火煎煮,沸后转文火煮32分钟,滤出药液,浓缩成60°C下相对密度为1. 27的药膏; (2) 将酒药花放入沸水中,加盖,浸泡3小时后捞出沥干,然后晒干,研成细粉,过150目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/5的凡士林,调勾,即得。 [0025] The production method of treating tinea pedis external preparation is: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, the amount of water was added 6.8 times, first Wuhuo boiling, boiling after turn Simmer for 32 minutes, the liquid was filtered, concentrated to the relative density of 1.27 60 ° C for ointments; (2) into the boiling water Jiuyao flowers, capped, soaked for 3 hours remove and drain, then dried, and research into a fine powder, over 150 mesh sieve; (3) the drug substance in addition to taste 8 large Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle co grind fine, over 150 mesh sieve; (4) the step (1), the resultant total weight of the step (2) and (3) mixing, added in step (1), step (2) and (3) 1 / Vaseline 5, transfer hook, that is, too.

[0026] 本发明所得治疗足癣的外用剂的使用方法是:外用,取本发明所得产品涂于患处, 每日早晚两次。 [0026] The external preparation obtained using the method of the present invention is the treatment of tinea pedis: topical, take the resulting product of the present invention onto the affected area twice a day morning and evening.

[0027] 实施例2治疗足癣的外用剂,取下述重量份的主要原料药制备而成(每份为700g): 巴戟天15份,大飞扬草16份,单条草17份,古山龙12份,藜芦14份,蚕豆壳12份,酒药花13份,红果楠12份,蓖麻叶16份,倒扣草17份,佩兰15份,筠酱叶17份,霸王鞭14份,百合18份。 [0027] The treatment of tinea pedis external preparation in Example 2, the following parts by weight was prepared taking mainly from drug (as per 700g): 15 parts by Morinda, Euphorbia hirta large parts 16, 17 parts of a single grass, gushan Long 12 parts, 14 parts of hellebore, shell beans 12 parts, 13 parts Jiuyao flowers, red berries Nan 12 parts, 16 parts of castor leaves, grass upside down, 17 parts, 15 parts Perrin, Jun 17 parts butter leaf, rattle 14 copies lily 18 copies.

[0028] 上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入8. 4倍量水,先用武火煎煮,沸后转文火煮46分钟,滤出药液,浓缩成60°C下相对密度为1. 32的药膏; (2) 将酒药花放入沸水中,加盖,浸泡5小时后捞出沥干,然后晒干,研成细粉,过150目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量3/5的凡士林,调勾,即得。 [0028] The production method of treating tinea pedis external preparation is: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, the amount of water was added 8.4 times, first Wuhuo boiling, boiling after turn Simmer for 46 minutes, the liquid was filtered, concentrated to the relative density of 1.32 60 ° C for ointments; (2) into the boiling water Jiuyao flowers, stamped, soak for 5 hours remove and drain, then dried, and research into a fine powder, over 150 mesh sieve; (3) the drug substance in addition to taste 8 large Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle co grind fine, over 150 mesh sieve; (4) the step (1), the resultant total weight of the step (2) and (3) mixing, added in step (1), step (2) and (3) 3 / Vaseline 5, transfer hook, that is, too.

[0029] 典型病例一:高XX,男,36岁。 [0029] a typical case: high-XX, male, 36 years old. 主诉:患有足癣2年余。 Chief Complaint: suffering from athlete's foot more than 2 years. 患者患有足癣2年,在此期间,曾尝试多种方法治疗,均未能治愈。 Patients suffering from athlete's foot for 2 years, during this period, have tried various treatment methods, have failed to cure. 2009年4月13日来诊。 April 13, 2009 to consultation. 患者右足二趾、三趾间肿痛,足背浮肿。 Patients with right foot second toe and third interdigital swelling, edema dorsum of the foot. 左足二趾、三趾间有水汁出,瘙痒疼痛。 Left foot toe two, three interdigital water out of juice, itching pain. 诊断为足癣。 Diagnosis of athlete's foot. 使用本实施例所得治疗足癣的外用剂,取本实施例所得产品涂于患处,每日早晚两次。 Example embodiment using the obtained external preparation for the treatment of tinea pedis, take the product obtained in Example embodiment applied to the affected area, twice a day morning and evening. 治疗3天,症状缓解。 Treatment for 3 days, relief of symptoms. 治疗6天后,所有症状消失,痊愈。 6 days after treatment, all the symptoms disappear, recovered. 随访未复发。 Follow-up without recurrence.

[0030] 实施例3治疗足癣的外用剂,取下述重量份的主要原料药制备而成(每份为700g): 巴戟天11份,大飞扬草12份,单条草10份,古山龙10份,藜芦9份,蚕豆壳8份,酒药花10 份,红果楠9份,蓖麻叶12份,倒扣草11份,佩兰10份,筠酱叶12份,霸王鞭11份,百合12 份。 [0030] Example 3 Topical agents for the treatment of tinea pedis, prepared from (to 700 g of each) to take the following main parts by weight of the drug: 11 parts by Morinda, Euphorbia hirta large parts 12, 10 parts of a single grass, gushan Long 10 parts, hellebore nine, eight shell beans, Jiuyao spend 10 parts, red Nan 9 parts, 12 parts of castor leaves, grass upside down 11 parts, 10 parts Perrin, Jun 12 parts butter leaf, rattle 11 copies lily 12 copies.

[0031] 上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入7. 5倍量水,先用武火煎煮,沸后转文火煮35分钟,滤出药液,浓缩成60°C下相对密度为1. 29的药膏; (2) 将酒药花放入沸水中,加盖,浸泡3. 2小时后捞出沥干,然后晒干,研成细粉,过150 目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4)将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/4的凡士林,调勾,即得。 [0031] The production method of treating tinea pedis external preparation is: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, the amount of water was added 7.5 times, first Wuhuo boiling, boiling after turn Simmer for 35 minutes, the liquid was filtered, concentrated to 60 ° C under a relative density of 1.29 creams; (2) into the boiling water Jiuyao flowers, stamped, soak 3.2 after hours remove and drain, then dried, and research into a fine powder, over 150 mesh sieve; (3) in addition to the large Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle of 8 taste of raw materials drug were fine, through 150 mesh sieve; (4) the step (1), the resultant total weight of the step (2) and (3) mixing, added in step (1), step (2) and (3) 1/4 Vaseline, transfer hook, that is, too.

[0032] 典型病例二:陈XX,男,42岁。 [0032] Typical Case II: Chen XX, male, 42 years old. 主诉:患足癣5年余。 Chief Complaint: suffering from athlete's foot more than 5 years. 曾使用多种药物治疗,效果不佳。 He had used a variety of drugs, ineffective. 2009年4月16日来诊。 April 16, 2009 to consultation. 诊见患者双足脚趾、脚掌瘙痒,脚趾水疱脱皮,双足跟及双足后脚掌皮肤增厚、粗糙皲裂夹杂鳞肩角化。 See diagnosed patients feet toes, feet itching, blisters and peeling toe, heel and rear feet feet feet skin thickening, rough and chapped mixed scales shoulder keratosis. 使用本实施例所得治疗足癣的外用剂,取本实施例所得产品涂于患处,每日早晚两次。 Example embodiment using the obtained external preparation for the treatment of tinea pedis, take the product obtained in Example embodiment applied to the affected area, twice a day morning and evening. 治疗5天,症状明显减轻。 For 5 days, significantly reduced the symptoms. 继续使用5天,诸症全消而痊愈。 Continue to 5 days, Zhu Zheng totally disappeared and healed. 随访至今未复发。 Follow-up so far no recurrence.

[0033] 实施例4治疗足癣的外用剂,取下述重量份的主要原料药制备而成(每份为700g): 巴戟天13份,大飞扬草14份,单条草15份,古山龙11份,藜芦13份,蚕豆壳11份,酒药花12份,红果楠11份,蓖麻叶14份,倒扣草15份,佩兰13份,筠酱叶15份,霸王鞭13份,百合16份。 [0033] The external agent for the treatment of tinea pedis in Example 4, prepared from (to 700 g of each) to take the following main parts by weight of the drug: 13 parts by Morinda, Euphorbia hirta large parts 14, 15 parts of a single grass, gushan Long 11 parts, 13 parts of hellebore, shell beans 11 parts, 12 parts Jiuyao flowers, red berries Nan 11 parts, 14 parts of castor leaves, grass upside down, 15 parts, 13 parts Perrin, Jun 15 parts butter leaf, rattle 13 copies lily 16 copies.

[0034]上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入8. 2倍量水,先用武火煎煮,沸后转文火煮42分钟,滤出药液,浓缩成60°C下相对密度为1. 31的药膏; (2) 将酒药花放入沸水中,加盖,浸泡4. 6小时后捞出沥干,然后晒干,研成细粉,过150 目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/2的凡士林,调勾,即得。 [0034] The production method of treating tinea pedis external preparation is: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, the amount of water was added 8.2-fold, first Wuhuo boiling, boiling after turn Simmer for 42 minutes, the liquid was filtered, concentrated to the relative density of 1.31 60 ° C for ointments; (2) into the boiling water Jiuyao flowers, stamped, soak 4.6 after hours remove and drain, then dried, and research into a fine powder, over 150 mesh sieve; (3) in addition to the large Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle of 8 taste of raw materials drug were fine, through 150 mesh sieve; (4) the step (1), the resultant total weight of the step (2) and (3) mixing, added in step (1), step (2) and (3) 1/2 Vaseline, transfer hook, that is, too.

[0035] 典型病例三:孙XX,女,28岁。 [0035] Typical Case III: Sun XX, female, 28 years old. 主诉:患有足癣4年余。 Chief Complaint: suffering from athlete's foot more than four years. 4年前,患者被查出患有足癣。 Four years ago, the patient was diagnosed with athlete's foot. 4年来,患者曾尝试多种治疗足癣的方法,治疗效果不佳。 4 years, patients have tried several ways to treat athlete's foot, and poor treatment. 2008年6月8日来诊。 2008 June 8 to consultation. 患者双脚第五与四趾间、第三与二趾间有散在的红色小水疱,糜烂流水,瘙痒疼痛,舌质红,舌苔薄黄,脉滑数。 Patients and four feet fifth toes, and a third two webbed red scattered small blisters, erosion, water, pain, itching, red tongue, tongue thin yellow, slippery pulse number. 诊断为足癣。 Diagnosis of athlete's foot. 使用本实施例所得治疗足癣的外用剂,取本实施例所得产品涂于患处,每日早晚两次。 Example embodiment using the obtained external preparation for the treatment of tinea pedis, take the product obtained in Example embodiment applied to the affected area, twice a day morning and evening. 治疗3天,症状减轻。 Treatment for 3 days, to alleviate the symptoms. 继续使用一周,诸症全消。 Continued one week, Zhu Zheng totally disappeared. 随访至今未复发。 Follow-up so far no recurrence.

[0036] 实施例5治疗足癣的外用剂,取下述重量份的主要原料药制备而成(每份为700g): 巴戟天12份,大飞扬草13份,单条草13份,古山龙10. 5份,藜芦11份,蚕豆壳9份,酒药花11份,红果楠10份,蓖麻叶13份,倒扣草12份,佩兰12份,筠酱叶14份,霸王鞭12份, 百合15份。 [0036] The external agent for the treatment of tinea pedis in Example 5, prepared from (to 700 g of each) to take the following main parts by weight of the drug: 12 parts by Morinda, Euphorbia hirta large parts 13, 13 parts of a single grass, gushan Long 10.5 parts, 11 parts by veratridine, bean shell parts 9, 11 Jiuyao flower parts, 10 parts of red berries Nan, 13 parts of castor leaves, grass undercut 12 parts, 12 parts by Perrin, 14 parts butter leaf Yun, rattle 12 parts, 15 parts lily.

[0037] 上述治疗足癣的外用剂的制备方法是: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入7. 8倍量水,先用武火煎煮,沸后转文火煮37分钟,滤出药液,浓缩成60°C下相对密度为1. 3的药膏; (2) 将酒药花放入沸水中,加盖,浸泡3. 8小时后捞出沥干,然后晒干,研成细粉,过150 目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/3的凡士林,调勾,即得。 [0037] The production method of treating tinea pedis external preparation is: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and rattle into the pot, the amount of water was added 7.8 times, first Wuhuo boiling, boiling after turn Simmer for 37 minutes, the liquid was filtered, concentrated to a relative density of 1.3 to 60 ° C for ointments; (2) into the boiling water Jiuyao flowers, stamped, soak 3.8 after hours remove and drain, then dried, and research into a fine powder, over 150 mesh sieve; (3) in addition to the large Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle of 8 taste of raw materials drug were fine, through 150 mesh sieve; (4) the step (1), the resultant total weight of the step (2) and (3) mixing, added in step (1), step (2) and (3) 1/3 Vaseline, transfer hook, that is, too.

[0038] 本发明所用主要中药原料的药理如下: 巴戟天:基原:为双子叶植物药茜草科植物巴戟天的根。 [0038] The main material of the present invention is used in medicine pharmacological following: Morinda: original group: root of Morinda dicotyledonous herbal Rubiaceae. 药性:辛、甘,温。 Medicinal properties: acrid, sweet, warm. 归肝、肾经。 The liver and kidney. 功用主治:补肾助阳,强筋壮骨,祛风除湿。 Indications: kidney yang, strengthening sinews and bones, Qufengchushi. 用于肾虚阳瘘,遗精早泄,少腹冷痛,小便不禁, 宫冷不孕,风寒湿痹,腰膝酸软,风湿肢气。 For kidney Yang fistula, premature ejaculation, nocturnal emission, lower abdomen Leng Tong, urine can not help, palace cold infertility, wind musculoskeletal, waist and knees, rheumatism limb gas.

[0039] 大飞扬草:基原:为大戟科植物飞扬草的带根全草。 [0039] big Euphorbia hirta: Base of the original: Euphorbiaceae plant Euphorbia hirta the whole plant with roots. 药性:辛;酸;惊;小毒。 Herbs: oct; acid; panic; small drug. 归肺、 肝经。 In the lungs, the liver. 功用主治:清热解毒;利湿止痒;通乳。 Indications: detoxification; dampness itching; lactation. 主肺痈;乳痈;痢疾;泄泻;热淋;血尿;湿瘆; 脚癣;皮肤瘙痒;疔疮肿毒;牙疳;产后少乳。 Primary lung abscess; mastitis; dysentery; diarrhea; hot shower; hematuria; wet Shen; athlete's foot; itching; swollen boils poison; Yagan; less milk after childbirth.

[0040] 单条草:基原:为报春花科植物泽珍珠菜的全草。 [0040] a single grass: Base of the original: the whole grass plant Primulaceae Lysimachia of Chak. 药性:苦,凉。 Herbs: bitter, cold. 功用主治:清热解毒;活血止痛;利湿消肿。 Indications: detoxification; Huoxuezhitong; dampness swelling. 主治咽喉肿痛,痈肿疮毒,乳痈,毒蛇咬伤,跌打骨折,风湿痹痛, 脚气水肿,稻田性皮炎。 Indications sore throat, sore carbuncles, mastitis, snake bites, bone fractures, rheumatism, beriberi edema, paddy dermatitis.

[0041] 古山龙:基原:为防己科植物古山龙的根或茎藤。 [0041] Long ancient mountain: Base of the original: to prevent yourself plants ancient mountain dragon root or stem vine. 药性:苦;寒;小毒。 Herbs: bitter; cold; a small drug. 归心、肺、大肠经。 Heart, lung, large intestine. 功用主治:清热利湿;泻火解毒。 Indications: heat and dampness; purging fire detoxification. 主肠炎;菌痢;黄疸;疟疾;疖肿;湿瘆;阴道炎;支气管炎;百日咳;扁桃体炎;眼结膜炎。 Main colitis; dysentery; jaundice; malaria; Boil; Shen wet; vaginitis; bronchitis; pertussis; Tonsillitis; conjunctivitis.

[0042] 藜芦:基原:为百合科植物藜芦、牯岭藜芦、毛穗藜芦、兴安藜芦及毛叶藜芦的根及根茎。 [0042] hellebore: Base of the original: Liliaceae hellebore, Kuling hellebore, ear hair hellebore, hellebore and Xing'an hairy leaves hellebore roots and rhizomes. 药性:苦;辛;寒;有毒。 Herbs: bitter; Xin; cold; toxic. 归肺、胃、肝经。 In the lungs, stomach, liver. 功用主治:涌叶风痰;杀虫。 Indications: Ye Feng Chung sputum; insecticide. 主中风痰壅; 癫痫;虐疾;疥癣;恶疮。 Master stroke phlegm; epilepsy; malaria; scabies; malignant sore.

[0043] 蚕豆壳:基原:为豆科巢菜属植物蚕豆的种皮。 [0043] bean shell: the original group: testa genus Leguminosae Vicia faba bean. 药性:甘、淡,平。 Herbs: sweet, bland, flat. 功用主治:利水渗湿,止血,解毒。 Indications: Water Shenshi, bleeding, detoxification. 主治水肿,脚气,小便不利,吐血,胎漏,下血,天泡疮,黄水疮,瘰疬。 Indications edema, beriberi, dysuria, vomiting, Tailou, blood, bubble days sores, impetigo, M. scrofulaceum.

[0044] 酒药花:基原:为醉鱼草科植物大叶醉鱼草的枝叶、根皮。 [0044] Jiuyao flowers: Base of the original: as drunk fish growing woody plant foliage large leaves drunk fish grass, root bark. 药性:辛,微苦,性温,有毒。 Potency: octyl, bitter, warm, toxic. 归心、肝、肾经。 The heart, liver and kidney. 功用主治:祛风散寒;活血止痛;解毒杀虫。 Indications: expelling wind and cold; Huoxuezhitong; insecticide detoxification. 主风寒咳嗽;痹痛;跌打损伤;痈肿疮疖;妇女阴痒;麻风;脚癣。 Primary treatment of cough; arthralgia; bruises; carbuncle swollen boils; women Yin Yang; leprosy; athlete's foot.

[0045] 红果楠:基原:为樟科植物红果黄肉楠的根或叶。 [0045] Hongguo Nan: Base of the original: as Lauraceae red berries yellow flesh Nan roots or leaves. 药性:辛;性平。 Herbs: oct; flat. 归肺经。 After the lung. 功用主治:清热消肿;降逆止呕。 Indications: heat and swelling; Jiangni vomiting. 主水火烫伤;脚癣;痔疮;恶心呕吐。 Main water and fire burns; athlete's foot; hemorrhoids; nausea and vomiting.

[0046] 蓖麻叶:基原:为大戟科植物蓖麻的叶。 [0046] Castor Leaf: base of the original: Euphorbiaceae plant castor leaves. 药性:味苦;辛;性平;小毒。 Herbs: bitter; oct; nature; small drug. 功用主治: 祛风除湿;拔毒消肿。 Indications: Qufengchushi; Sida swelling. 主脚气;风湿痹痛;痈疮肿毒;疥癣瘙痒;子宫下垂;脱肛;咏嗽痰喘。 Main athlete's foot; rheumatism; carbuncle swollen poison; scabies itching; uterine prolapse; prolapse; cough Tan Chuan Yong. [0047] 倒扣草:基原:为苋科植物粗毛牛膝的全草。 [0047] grass upside down: Base of the original: to shag Amaranthaceae Achyranthes plant the whole plant. 药性:苦;酸;性微寒。 Herbs: bitter; acid; slightly cold. 归肝、肺、膀胱经。 Liver, lung, bladder through. 功用主治:活血化瘀;利尿通淋;清热解表。 Indications: blood circulation; tonglin diuretic; heat relieving. 主经闭;痛经;月经不调;跌打损伤;风湿关节痛;淋病;水肿;湿热带下,外感发热;疟疾;咽痛;疔疮痈肿。 Primary amenorrhea; dysmenorrhea; irregular menstruation; bruises; rheumatoid arthritis; gonorrhea; edema; vaginal discharge heat, exogenous fever; malaria; sore throat; boils carbuncle.

[0048] 佩兰:基原:为菊科植物兰草的茎叶。 [0048] Perrin: original group: in leaves Compositae bluegrass. 化学成分:兰草全草含挥发油1. 5~2%,油中含:对-聚伞花素乙酸橙花醇酯和5-甲基麝香草醚,前两者对流感病毒有直接抑制作用。 Chemical composition: bluegrass whole plant volatile oil containing 1.5 to 2% of oil containing: for - cymene neryl esters and 5-methyl thyme poly ether, the former two have a direct inhibitory effect on influenza virus. 叶含香豆精,邻-香豆酸及麝香草氢醌。 Leaves contain coumarin, o - coumaric acid, hydroquinone and thyme. 药性:辛,平。 Herbs: oct flat. 入脾、胃经。 Rupi, stomach. 功用主治:清暑,辟秽, 化湿,调经。 Indications: Qingshu, the provision of foul, dampness, regulate menstruation. 治感受暑湿,寒热头痛,湿邪内蕴,脘痞不饥,口甘苔腻,月经不调。 Governance experience Shushi, chills and fever, headache, wet evil connotation, abdominal swelling, no hunger, Gan greasy mouth, irregular menstruation.

[0049] 筠酱叶:基原:为胡椒科植物筠酱的叶。 [0049] Yun Ye sauce: Base of the original: Jun sauce for the pepper plants leaves. 药性:辛;温。 Herbs: Xin; temperature. 归肺、胃经。 In the lungs, stomach. 功用主治:疏风散寒,行气化痰,解毒消肿,燥湿止痒。 Indications: Expel wind and cold, qi and phlegm, detoxification swelling, dampness itching. 主风寒咳嗽,哮喘,百日咳,院腹胀痛,食滞纳呆,水月中,跌打伤肿,风湿骨痛,疮疡肿毒,痔疮肿痛,汤火伤,风毒脚气,疥癞,湿瘆疫痒。 Primary treatment of cough, asthma, whooping cough, the hospital pain, bloating, indigestion, poor appetite, Moon Water, a swollen or injured, rheumatism, sores, hemorrhoids swelling, soup burns, athlete's foot wind poison, scabies skin disease, wet Shen immune itch.

[0050] 霸王鞭:基原:为大戟科植物霸王鞭的全株。 [0050] rattle: Base of the original: the whole plant is Euphorbiaceae rattle of. 药性:苦涩;平;有毒。 Herbs: bitter; flat; toxic. 归心、脾经。 The heart, spleen. 功用主治:祛风解毒;杀虫止痒。 Indications: Qufeng detoxification; insecticidal itching. 主疮疡肿毒;牛皮癣。 Main sores; psoriasis.

[0051] 百合:基原:为百合科植物卷丹、百合或细叶百合的干燥肉质鳞叶。 [0051] Lily: Base of the original: dried fleshy scale leaves lily Liliaceae lancifolium, lily or Egeria. 药性:甘,寒。 Herbs: sweet, cold. 归心、肺经。 Heart, lung. 功用主治:养阴润肺,清心安神。 Indications: Yin lungs, pure heart and soothe the nerves. 用于阴虚久咳,痰中带血,虚烦惊悸,失眠多梦,精神恍惚。 For yin deficiency cough, bloody sputum, virtual annoying palpitation, insomnia, trance.

[0052] 试验例1本发明所得治疗足癣的外用剂(实施例5)的临床应用:2007年5月-2009 年6月,在3所医院筛选260例足癣患者,其中男性140例,女性120例,年龄19-62岁,平均年龄40.8岁。 Clinical application of [0052] the present invention obtained in Example 1 Test treating tinea pedis external preparation (Example 5): 2007 - 2009 June 3 hospitals filter 260 cases of tinea pedis patients, male 140 cases 120 cases of women, aged 19-62 years, mean age 40.8 years old. 随机分为两组,实验组及对照组(每组130例)。 Randomly divided into two groups, experimental and control groups (n = 130 cases). 两组患者间性别、年龄、病情及病程等方面进行比较,差异无统计学意义(P > 0. 05),具有可比性。 Between the two groups in gender, age, severity and duration were compared, the difference was not statistically significant (P> 0. 05), comparable.

[0053] 治疗方法:实验组使用本发明所得治疗足癣的外用剂,使用方法为:外用,取本发明所得产品涂于患处,每日早晚两次,5天为一个疗程。 [0053] Treatment methods: the experimental group and obtained this invention to treat tinea pedis external preparation, use is: topical, take the resulting product of the present invention applied to skin, morning and evening twice a day, 5 days a course of treatment. 对照组使用常规治疗足癣的药物(如珊瑚癣净、复方酮康唑乳膏、派瑞松乳膏等),5天为一个疗程。 The control group conventional drug treatment of tinea pedis (ringworm net such as coral, compound ketoconazole cream, cream Pevisone etc.), 5 days a course of treatment. 两组患者均治疗两个疗程后进行疗效比较。 Patients in both groups were compared after two courses of treatment efficacy.

[0054] 疗效情况判断标准:痊愈:临床症状全部消失,皮损痊愈;好转:临床症状明显减轻,皮损恢复;无效:症状及皮损均无明显改善。 [0054] When it is determined efficacy criteria: cured: clinical symptoms disappeared, skin lesions healed; improved: reduce the clinical symptoms, skin lesions recovery; invalid: no significant improvement in symptoms and skin lesions. 总有效包括痊愈和好转,结果如表1所示。 The total effective include improved recovery and the results are shown in Table 1.

[0055] 表1:本发明所得治疗足癣的外用剂效果验证 [0055] Table 1: Treatment of tinea pedis of this invention was to verify the effect of the external preparation

Figure CN104971209AD00091

疗效分析:两组病例治疗两个疗程后,实验组疫愈106例,好转22例,无效2例,总有效率98. 46% ;对照组痊愈62例,好转40例,无效28例,总有效率78. 46%。 Efficacy Analysis: two groups of patients after two courses, more experimental groups Phytophthora 106 cases, 22 cases improved, 2 cases, the total efficiency of 98.46%; control group cured 62 cases, improved in 40 cases, 28 cases ineffective, the total 78.46% efficiency. 实验组的痊愈率和总有效率明显高于对照组。 The cure rate and the total experimental group was significantly higher. 试验表明,实验组的临床疗效明显优于对照组,差异显著(P < 0.05),具有统计学意义。 Tests showed that the clinical efficacy of the experimental group than the control group, the difference was significant (P <0.05), statistically significant.

[0056] 本发明以巴戟天、大飞扬草、单条草和古山龙等为主要原料药,制成治疗足癣的外用剂。 [0056] In the present invention, Morinda, Euphorbia hirta large, single long grass and gushan as the main drug, external medicine for treatment is made tinea pedis. 方中巴戟天补肾助阳,强筋壮骨,祛风除湿。 Fang Morinda kidney yang, strengthening sinews and bones, Qufengchushi. 大飞扬草清热解毒;利湿止痒;通乳。 Large Euphorbia hirta detoxification; dampness itching; lactation. 单条草清热解毒;活血止痛;利湿消肿。 Single grass detoxification; Huoxuezhitong; dampness swelling. 古山龙清热利湿;泻火解毒。 Gushan Long heat and dampness; purging fire detoxification. 藜芦涌叶风痰;杀虫。 Hellebore Chung-bladed sputum; insecticide. 蚕豆壳利水渗湿,止血,解毒。 Water Shenshi bean shell, bleeding, detoxification. 酒药花祛风散寒;活血止痛;解毒杀虫。 Jiuyao spend comfortable and easy; Huoxuezhitong; insecticide detoxification. 红果楠清热消肿;降逆止呕。 Hongguo Nan heat swelling; Jiangni vomiting. 蓖麻叶祛风除湿;拔毒消肿。 Castor Leaf Qufengchushi; Sida swelling. 倒扣草活血化瘀;利尿通淋;清热解表。 Grass upside down blood circulation; diuretic Tonglin; heat relieving. 佩兰清暑,辟秽,化湿,调经。 Perrin Qingshu, the provision of foul, dampness, regulate menstruation. 筠酱叶疏风散寒,行气化痰,解毒消肿,燥湿止痒。 Yun sauce leaves Expel wind and cold, qi and phlegm, detoxification swelling, dampness itching. 霸王鞭祛风解毒;杀虫止痒。 Rattle chills and detoxification; insecticidal itching. 百合养阴润肺,清心安神。 Lily Yin lungs, pure heart and soothe the nerves. 诸药合用,共奏燥湿止痒、清热解毒、祛风除湿、杀虫止痒、泻火解毒、消肿止痛之功效,最终达到治愈足癣的目的。 Various drugs, played a total of dampness itching, detoxification, expelling wind and dampness, insecticidal itching, purging fire detoxification, swelling and pain effect, and ultimately achieve the purpose of cure athlete's foot.

[0057]最后应说明的是,实施例只是本发明最优的具体实施方式而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换。 [0057] Finally, it should be noted that the embodiments of the present invention is optimal only specific embodiments, but not intended to limit the present invention. Although the present invention has been described in detail embodiments, those skilled in the art that aspect, each of which can still be described embodiments of the foregoing embodiment may be modified, or some technical features equivalents. 凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。 Any modification within the spirit and principle of the present invention, made, equivalent substitutions, improvements, etc., should be included within the scope of the present invention.

Claims (9)

  1. 1. 治疗足癣的外用剂,其特征在于,取下述重量配比的主要原料药制备而成:巴戟天9-15,大飞扬草11-16,单条草8-17,古山龙9-12,藜芦7-14,蚕豆壳6-12,酒药花9-13,红果楠8-12,蓖麻叶10-16,倒扣草9-17,佩兰7-15,筠酱叶11-17,霸王鞭9-14,百合11-18。 1 topical agent for the treatment of tinea pedis, characterized in that the weight ratio prepared by taking the following main drug: Morinda 9-15, 11-16 Euphorbia hirta large, single grass 8-17, Long gushan 9 12, hellebore 7-14, shell beans 6-12, 9-13 Jiuyao flowers, red berries Nan 8-12, 10-16 castor leaves, grass upside down 9-17, 7-15 Perrin, Yun Ye sauce 11-17, rattle 9-14, 11-18 lily.
  2. 2. 如权利要求1所述的治疗足癣的外用剂,其特征在于,取下述重量配比的主要原料药制备而成:巴戟天11-13,大飞扬草12-14,单条草10-15,古山龙10-11,藜芦9-13,蚕豆壳8-11,酒药花10-12,红果楠9-11,蓖麻叶12-14,倒扣草11-15,佩兰10-13,筠酱叶12-15,霸王鞭11-13,百合12-16。 2. The external preparation of the treatment of tinea pedis claimed in claim 1, wherein the weight ratio prepared by taking the main drug from: Morinda 11-13, 12-14 Euphorbia hirta large, single grass 10-15, 10-11 ancient mountain dragon, hellebore 9-13, shell beans 8-11, 10-12 Jiuyao flower, red Nan 9-11, 12-14 castor leaves, grass upside down 11-15, Perrin 10-13, 12-15 Jun sauce leaf, rattle 11-13, 12-16 lily.
  3. 3. 如权利要求1所述的治疗足癣的外用剂,其特征在于,取下述重量配比的主要原料药制备而成:巴戟天12,大飞扬草13,单条草13,古山龙10. 5,藜芦11,蚕豆壳9,酒药花11, 红果楠10,蓖麻叶13,倒扣草12,佩兰12,筠酱叶14,霸王鞭12,百合15。 Long gushan Morinda 12, 13 Euphorbia hirta large, single grass 13: 3. The treatment of tinea pedis claimed in external preparation according to claim 1, wherein the weight ratio prepared by taking the main drug from 10.5, 11 veratridine, bean shells 9, 11 Jiuyao flower, red Nan 10, 13 castor leaves, grass undercuts 12, 12 Perrin, leaves 14 Jun sauce, rattle 12, 15 lilies.
  4. 4. 如权利要求1~3任一所述的治疗足癣的外用剂的制备方法,其特征在于,步骤如下: (1) 将大飞扬草、古山龙、藜芦、蓖麻叶和霸王鞭放入锅中,加入6. 8-8. 4倍量水,先用武火煎煮,沸后转文火煮32-46分钟,滤出药液,浓缩成60°C下相对密度为1. 27-1. 32的药膏; (2) 将酒药花放入沸水中,加盖,浸泡3-5小时后捞出沥干,然后晒干,研成细粉,过150 目筛; (3) 将除大飞扬草、古山龙、藜芦、酒药花、蓖麻叶和霸王鞭外的8味原料药共研细末, 过150目筛; (4) 将步骤(1)、步骤(2 )和步骤(3 )混匀,加入步骤(1)、步骤(2 )和步骤(3 )所得总重量1/5-3/5的凡士林,调勾,即得。 4. A method of preparing an external preparation according to claims 1 to 3, the treatment of tinea pedis claimed in claim, wherein the following steps: (1) large Euphorbia hirta, gushan Long, veratridine, castor leaves and put rattle wok added 6. 8-8. 4-fold amount of water, first Wuhuo boiling, boiling after turn Simmer 32-46 minutes, the liquid was filtered, concentrated to the relative density of 1. 60 ° C for 27- creams 1.32; and (2) into the boiling water Jiuyao flowers, capped, soaked 3-5 hours remove and drain, and then dried, reduced to powder, through a 150 mesh sieve; (3) 8 in addition to great taste API Euphorbia hirta, ancient mountain dragon, hellebore, alcohol and drug flowers, leaves and castor rattle of research to fine, over 150 mesh sieve; (4) the step (1), step (2) and step (3) mixing, added in step (1), step (2) and (3) the resulting total weight of petrolatum 1 / 5-3 / 5, the transfer hook, that is, too.
  5. 5. 如权利要求4所述的治疗足癣的外用剂的制备方法,其特征在于,步骤(1)中加入7. 5-8. 2倍量水(优选加入7. 8倍量水)。 5. The method of preparing the external preparation of the 4 treatment of tinea pedis claimed in claim, wherein step (1) was added 7. 5-8. 2-fold amount of water (preferably 7.8-fold amount of water was added).
  6. 6. 如权利要求4所述的治疗足癣的外用剂的制备方法,其特征在于,步骤(1)中沸后转文火煮35-42分钟(优选沸后转文火煮37分钟)。 The method of preparing the external preparation of the 4 treatment of tinea pedis claimed in claim 6, wherein, after the step (1) boiling in turn Simmer 35-42 minutes (after boiling turn Simmer preferably 37 minutes).
  7. 7. 如权利要求4所述的治疗足癣的外用剂的制备方法,其特征在于,步骤(1)中浓缩成60°C下相对密度为1. 29-1. 31的药膏(优选浓缩成60°C下相对密度为1. 3的药膏)。 7. The method of preparing the external preparation of the 4 treatment of tinea pedis claimed in claim, wherein the concentration step (1) to a relative density of 1. 29-1. 31 to 60 ° C for creams (preferably concentrated to a 60 ° C under a relative density of 1.3 ointments).
  8. 8. 如权利要求4所述的治疗足癣的外用剂的制备方法,其特征在于,步骤(2)中浸泡3. 2-4. 6小时后捞出沥干(优选浸泡3. 8小时后捞出沥干)。 8. The method of preparing the external preparation of the 4 treatment of tinea pedis claimed in claim, wherein step (2) remove and drain soaking 3. 2-4. 6 hours (preferably 3.8 hours soak remove and drain).
  9. 9. 如权利要求4所述的治疗足癣的外用剂的制备方法,其特征在于,步骤(4)中加入步骤(1)、步骤(2)和步骤(3)所得总重量1/4-1/2的凡士林(优选加入步骤(1)、步骤(2)和步骤(3)所得总重量1/3的凡士林)。 9. The method of preparing the external preparation of the 4 treatment of tinea pedis claimed in claim, wherein the step of adding the step (1) (4), the resulting total weight of step (2) and (3) 1 / 4- 1/2 petrolatum (added in step (1) is preferably, in step (2) and (3) the resulting total weight of petrolatum 1/3).
CN 201510435435 2015-07-23 2015-07-23 Externally used agent for treating tinea pedis and preparation method thereof CN104971209A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201510435435 CN104971209A (en) 2015-07-23 2015-07-23 Externally used agent for treating tinea pedis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201510435435 CN104971209A (en) 2015-07-23 2015-07-23 Externally used agent for treating tinea pedis and preparation method thereof

Publications (1)

Publication Number Publication Date
CN104971209A true true CN104971209A (en) 2015-10-14

Family

ID=54268530

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201510435435 CN104971209A (en) 2015-07-23 2015-07-23 Externally used agent for treating tinea pedis and preparation method thereof

Country Status (1)

Country Link
CN (1) CN104971209A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013154806A1 (en) * 2012-04-10 2013-10-17 Van Aller Robert Thomas Herbal composition and a method of making thereof
CN104013851A (en) * 2014-06-24 2014-09-03 李文职 Traditional Chinese medicine (TCM) preparation for treating beriberi
CN104352923A (en) * 2014-11-29 2015-02-18 顾明明 Traditional Chinese medicine liquid for treating dermatophytosis and preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013154806A1 (en) * 2012-04-10 2013-10-17 Van Aller Robert Thomas Herbal composition and a method of making thereof
CN104013851A (en) * 2014-06-24 2014-09-03 李文职 Traditional Chinese medicine (TCM) preparation for treating beriberi
CN104352923A (en) * 2014-11-29 2015-02-18 顾明明 Traditional Chinese medicine liquid for treating dermatophytosis and preparation method

Similar Documents

Publication Publication Date Title
CN101181559A (en) Chinese medicine preparation for curing fungi dermatosis and preparation method thereof
CN1293968A (en) Coptis liquid for relieving inflammation and moistening skin and its preparing process
CN103520572A (en) Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition
CN101869626A (en) Chinese medicinal compound preparation private care liquid, and preparation and application thereof
CN102579912A (en) Chinese medicinal capsules special for treating acute mastitis and preparation method thereof
CN102614286A (en) Medicine for treating cold and preparation method for medicine
CN101190310A (en) Traditional Chinese medicine composition for treating mazopathy
CN102836357A (en) Traditional Chinese medicine preparations used for treating flat warts
CN102671054A (en) Traditional Chinese medicine composition for treating thrombophlebitis
CN101164600A (en) Medicine for treating acne and whelk
CN101057942A (en) External applied medicine ointment for treating diabetes foot and its preparing method
CN101269157A (en) Method for preparing wine for warming meridian, removing paralysism, releasing tendon, activating collaterals to relieve pain
CN103055116A (en) Traditional Chinese medicine composition for treating acnes
CN104784415A (en) Traditional Chinese medicine pill for treating acute eruptive infectious disease and preparation method
CN101239162A (en) Pearl stomach-nourishing powder
CN1323613A (en) Traditional Chinese medicine for 3D process treating condyloma acuminata
CN102861313A (en) Traditional Chinese medicine composition for promoting healing of post-operation scars
CN103690853A (en) Traditional Chinese medicinal preparation for treating wet-rot-type tinea pedis and preparation method thereof
CN100998740A (en) Atoxic traditional Chinese medicine composition for treating rheumatosis and rheumatoid disease
CN104055900A (en) Traditional Chinese medicine composition for treating urticaria
CN1478525A (en) Medicated wine for treating traumatic injury
CN103393916A (en) External use ointment used for treating dermatitis and preparation method thereof
CN103751633A (en) Traditional Chinese medicinal composition for treating varicose vein of lower limb and preparation method thereof
CN101912492A (en) Bitongling tincture
CN102000302B (en) Detumescent and analgesic ointment for curing rheumatism and contusion and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
COR Change of bibliographic data