CN108853293B - Compound essential oil for treating hemorrhoids and preparation method and use method thereof - Google Patents

Compound essential oil for treating hemorrhoids and preparation method and use method thereof Download PDF

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CN108853293B
CN108853293B CN201811117394.3A CN201811117394A CN108853293B CN 108853293 B CN108853293 B CN 108853293B CN 201811117394 A CN201811117394 A CN 201811117394A CN 108853293 B CN108853293 B CN 108853293B
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essential oil
oil
parts
compound
treating hemorrhoids
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CN108853293A (en
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伍振峰
黄小英
杨明
万娜
朱根华
王雅琪
康超超
王芳
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Jiangxi University of Traditional Chinese Medicine
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Abstract

The invention provides compound essential oil for treating haemorrhoids and a preparation method and a using method thereof, and relates to the technical field of essential oil, wherein the compound essential oil for treating haemorrhoids comprises the following components in parts by weight: the compound essential oil for treating the haemorrhoids not only can resist inflammation and sterilize, activate cells to repair and promote granulation growth and relieve pain quickly, but also can achieve the effects of supplementing each other and enhancing the effect and expanding the effect through the synergistic effect among the essential oils of all the components, and has the advantages of obvious curative effect, quick response, small toxic and side effect, simple manufacture, convenient use, greenness, health and good application prospect.

Description

Compound essential oil for treating hemorrhoids and preparation method and use method thereof
Technical Field
The invention relates to the technical field of essential oil, in particular to compound essential oil for treating haemorrhoids and a preparation method and a using method thereof.
Background
Hemorrhoid refers to pathological hypertrophy and downward movement of the anal pad, and rapid mass formation caused by blood stasis in perianal subcutaneous vascular plexus, accompanied by symptoms such as hemorrhage and prolapse. The hemorrhoids are common and frequent anorectal diseases in clinic and have high incidence rate, and the ten-person nine hemorrhoids are common. Clinically, the symptoms such as hematochezia, pain, prolapse and the like are mainly caused, the illness state is very easy to repeat, the patients at all ages can suffer from different physiological and psychological pains, and the life and the working quality of the patients with hemorrhoids are often greatly influenced.
At present, the treatment methods of hemorrhoids are more, the clinical treatment mainly comprises an operation, and the operation treatment effect is better, however, the pain of wounds after the hemorrhoid operation is intolerable due to the complicated anal canal nerves and blood vessels, the pain sense of nerves below the dentition and the like, and the complicated operation process, the postoperative complications and the like can increase the burden of patients. The medicament treatment method mainly comprises analgesic western medicines, and has the advantages of large toxic and side effects and slow response.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide compound essential oil for treating hemorrhoids, and solves the technical problems that the existing operation treatment process is complex, the postoperative complications are more, and western medicines have high toxic and side effects and slow effect.
The invention provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 1-3 parts of ligusticum wallichii essential oil, 0.4-1 part of bighead atractylodes rhizome essential oil, 0.2-0.8 part of notopterygium root essential oil, 0.2-0.8 part of tea tree essential oil, 0.15-0.75 part of forsythia suspensa essential oil, 0.1-0.6 part of rhizoma acori graminei essential oil and 0.05-0.15 part of cinnamon essential oil.
Further, the compound essential oil for treating hemorrhoids comprises the following components in parts by weight: 1.2-2.8 parts of ligusticum wallichii essential oil, 0.5-0.8 part of bighead atractylodes rhizome essential oil, 0.3-0.7 part of notopterygium root essential oil, 0.3-0.7 part of tea tree essential oil, 0.25-0.7 part of forsythia suspense essential oil, 0.25-0.5 part of rhizoma acori graminei essential oil and 0.07-0.13 part of cinnamon essential oil.
Further, the compound essential oil for treating hemorrhoids comprises the following components in parts by weight: 1.5-2.5 parts of ligusticum wallichii essential oil, 0.6-0.7 part of bighead atractylodes rhizome essential oil, 0.4-0.6 part of notopterygium root essential oil, 0.4-0.6 part of tea tree essential oil, 0.55-0.65 part of forsythia suspense essential oil, 0.3-0.4 part of rhizoma acori graminei essential oil and 0.08-0.12 part of cinnamon essential oil.
Further, the compound essential oil for treating hemorrhoids also comprises 1-3 parts of fig leaf essential oil and 1-3 parts of garden burnet essential oil in parts by mass;
preferably, 2 parts of fig leaf essential oil and 2 parts of sanguisorba essential oil are used.
Further, the compound essential oil for treating hemorrhoids also comprises 0-98 parts of base oil by mass;
preferably, the base oil is selected from at least one of sweet almond oil, grape seed oil, jojoba oil or wheat germ oil;
further preferably, the base oil is jojoba oil.
Further, the compound essential oil for treating hemorrhoids also comprises 0.5-2 parts of an auxiliary agent by mass;
preferably, the adjuvant comprises at least one of a gelling agent, a humectant, or a preservative.
Further, the gelling agent is selected from at least one of methylcellulose, hydroxypropyl methylcellulose, sodium hydroxymethyl cellulose, polyvinyl alcohol, pectin or gelatin;
preferably, the humectant is selected from at least one of polyethylene glycol, propylene glycol, hexylene glycol, isoprene glycol, butylene glycol, sorbitol, or glycerin;
preferably, the preservative is methyl isothiazolinone and/or ethylhexyl glycerin.
The second purpose of the invention is to provide a preparation method of compound essential oil for treating hemorrhoids, which comprises the following steps:
mixing rhizoma Ligustici Chuanxiong essential oil, Atractylodis rhizoma essential oil, Notopterygii rhizoma essential oil, tea tree essential oil, fructus forsythiae essential oil, rhizoma Acori Graminei essential oil, cortex Cinnamomi essential oil, optional folium fici essential oil, optional radix Sangusorbae essential oil, optional base oil and optional adjuvants uniformly to obtain the compound essential oil for treating hemorrhoid.
The third purpose of the invention is to provide a use method of the compound essential oil for treating hemorrhoids, which comprises the following steps:
the compound essential oil for treating hemorrhoids is smeared on an affected part and is massaged until being absorbed.
Further, before the compound essential oil for treating hemorrhoids is smeared on an affected part, the affected part is cleaned.
Compared with the prior art, the invention has the beneficial effects that:
the compound essential oil for treating hemorrhoids provided by the invention is extracted from pure natural plant essential oil, and on the basis of the combination of the traditional Chinese medicine compatibility theory and the essential oil blending technology, the essential oil for treating hemorrhoids is prepared and combined by taking ligusticum wallichii essential oil, bighead atractylodes rhizome essential oil, notopterygium root essential oil, tea tree essential oil, grassleaf sweelflag rhizome essential oil, fructus forsythiae essential oil and cinnamon essential oil as raw materials for the first time, has obvious anti-inflammatory and bactericidal effects, can activate cell self-repair and promote granulation growth and rapidly relieve pain, and has no toxic or side effect, green and healthy properties and high effect taking speed; on the basis of the compatibility theory of traditional Chinese medicines, the compound essential oil supplements each other and enhances the effect by utilizing the principle that the volatilization speeds of the essential oils in the formula are different, so that the curative effect is enlarged, the curative effect for treating the hemorrhoids is obvious, and the compound essential oil is very suitable for the public suffering from the hemorrhoids.
The preparation method of the compound essential oil for treating hemorrhoids, provided by the invention, is simple in process and convenient to operate, is suitable for industrial mass production, and can effectively improve the production efficiency.
The application method of the compound essential oil composition for treating the haemorrhoids, provided by the invention, is simple and convenient to use, saves time and labor, and can be conveniently used by a patient at any time.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer.
According to one aspect of the invention, the invention provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 1-3 parts of ligusticum wallichii essential oil, 0.4-1 part of bighead atractylodes rhizome essential oil, 0.2-0.8 part of notopterygium root essential oil, 0.2-0.8 part of tea tree essential oil, 0.15-0.75 part of forsythia suspensa essential oil, 0.1-0.6 part of rhizoma acori graminei essential oil and 0.05-0.15 part of cinnamon essential oil.
In the present invention, the typical but non-limiting mass portion of the ligusticum wallichii essential oil is 1, 1.2, 1.5, 1.8, 2.0, 2.2, 2.5, 2.8 or 3 portions. The essential oil has effects of promoting blood circulation, dispelling blood stasis, dispelling pathogenic wind, relieving pain, and improving local blood circulation.
Typical but not limiting mass parts of the essential oil of white atractylodes rhizome are, for example, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. The Atractylodis rhizoma essential oil has effects of invigorating spleen, invigorating qi, eliminating dampness, and promoting diuresis.
Typical but not limiting mass parts of notopterygium root essential oil are, for example, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75 or 0.8 parts. The Notopterygii rhizoma essential oil has effects of dispelling pathogenic wind, removing dampness and relieving pain.
Typical but not limiting parts by mass of the tea tree essential oil are, for example, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75 or 0.8 parts. The tea tree essential oil has the functions of clearing away heat and toxic materials and inhibiting bacteria.
Typical but not limiting parts by mass of forsythia essential oil are, for example, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.5, 0.55, 0.6, 0.65, 0.7 or 0.75 parts. The fructus forsythiae essential oil has effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogen accumulation.
Typical but not limiting mass parts of the grass-leaved sweetflag essential oil are, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55 or 0.6 parts. The rhizoma Acori Graminei essential oil has effects of eliminating dampness, activating qi-flowing, dispelling pathogenic wind, benefiting arthralgia, and relieving swelling and pain.
Typical but not limiting mass parts of cinnamon essential oil are for example 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.11, 0.12, 0.13, 0.14 or 0.15 parts. The cinnamon essential oil has the functions of dispelling cold, relieving pain, warming channels and promoting blood circulation.
The compound essential oil for treating hemorrhoids provided by the invention is extracted from pure natural plant essential oil, and on the basis of the combination of the traditional Chinese medicine compatibility theory and the essential oil blending technology, the essential oil for treating hemorrhoids is prepared and combined by taking ligusticum wallichii essential oil, bighead atractylodes rhizome essential oil, notopterygium root essential oil, tea tree essential oil, grassleaf sweelflag rhizome essential oil, fructus forsythiae essential oil and cinnamon essential oil as raw materials for the first time, has obvious anti-inflammatory and bactericidal effects, can activate cell self-repair and promote granulation growth and rapidly relieve pain, and has no toxic or side effect, green and healthy properties and high effect taking speed; on the basis of the compatibility theory of traditional Chinese medicines, the compound essential oil supplements each other and enhances the effect by utilizing the principle that the volatilization speeds of the essential oils in the formula are different, so that the curative effect is enlarged, the curative effect for treating the hemorrhoids is obvious, and the compound essential oil is very suitable for the public suffering from the hemorrhoids.
In a preferred embodiment of the invention, the compound essential oil for treating hemorrhoids further comprises 1-3 parts by mass of fig leaf essential oil and 1-3 parts by mass of sanguisorba essential oil.
Typical but not limiting parts by mass of the fig leaf essential oil in the present invention are e.g. 1, 1.2, 1.4, 1.6, 1.8, 2, 2.2, 2.4, 2.6, 2.8 or 3 parts.
The fig leaf essential oil has the effects of detoxifying, relieving swelling, promoting qi circulation and relieving pain, and is beneficial to playing a good auxiliary effect in treating the hemorrhoids.
In the present invention, the typical but non-limiting mass portion of the sanguisorba essential oil is 1, 1.2, 1.4, 1.6, 1.8, 2, 2.2, 2.4, 2.6, 2.8 or 3 parts.
The garden burnet essential oil has the effects of cooling blood and stopping bleeding, clearing heat and removing toxicity, reducing swelling and healing sore and the like, and can play a good auxiliary role in the treatment of the haemorrhoids.
In a further preferred embodiment of the present invention, the fig leaf essential oil is 2 parts and the sanguisorba essential oil is 2 parts.
In a preferred embodiment of the invention, the compound essential oil for treating hemorrhoids further comprises 0-98 parts by mass of base oil.
Typical but non-limiting mass parts of base oil in the present invention are e.g. 0, 3, 5, 8, 10, 13, 15, 18, 20, 23, 25, 28, 30, 33, 35, 38, 40, 43, 45, 48, 50, 53, 55, 58, 60, 63, 65, 68, 70, 73, 75, 78, 80, 83, 85, 88, 90, 93, 95 or 98 parts.
In a further preferred embodiment of the invention, the base oil is selected from at least one of sweet almond oil, grape seed oil, jojoba oil or wheat germ oil.
Sweet almond oil is a neutral base oil, can promote cell renewal, and has the effects of easy absorption, nourishing and moisturizing, and eliminating red swelling, dryness and inflammation.
The grape seed oil has strong permeability, can moisten and soften skin, and has antioxidant and astringent effects.
Jojoba oil has strong permeability, and can moisten, moisturize and care skin.
The wheat germ oil has effects of promoting metabolism, promoting skin regeneration, resisting oxidation, moistening and keeping moisture.
In a still further preferred embodiment of the invention, the base oil is jojoba oil.
In a preferred embodiment of the invention, the compound essential oil for treating hemorrhoids further comprises 0.5-2 parts by mass of an auxiliary agent.
Typical but not limiting mass parts of auxiliaries in the context of the invention are, for example, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2 parts.
In a further preferred embodiment of the invention, the adjuvant comprises at least one of a gelling agent, a humectant or a preservative.
In a preferred embodiment of the present invention, the gelling agent is a water-soluble polymer, including but not limited to natural polymers, modified natural polymers and synthetic polymers.
The water-soluble polymer includes but is not limited to methylcellulose, hydroxypropyl methylcellulose phthalate, sodium hydroxymethylcellulose, hydroxymethylethyl cellulose, carboxymethylethylcellulose, cellulose acetate phthalate.
Modified natural high molecular substances include, but are not limited to, gum arabic, sodium alginate, propylene glycol alginate, agar, gelatin, xanthan gum, and the like.
Synthetic polymers include, but are not limited to, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetal diethylamino complex acid ester, methacrylic acid copolymer-L, methacrylic acid copolymer-LD, methacrylic acid copolymer-S, carboxyvinyl polymer, and the like.
In a further preferred embodiment of the invention, the gelling agent is selected from at least one of methylcellulose, hydroxypropylmethylcellulose, sodium hydroxymethylcellulose, polyvinyl alcohol, pectin or gelatin.
In a preferred embodiment of the invention, the humectant is selected from polyols.
Polyols include, but are not limited to, polyethylene glycol, propylene glycol, hexylene glycol, isoprene glycol, butylene glycol, sorbitol, or glycerol.
In a preferred embodiment of the invention, the preservative includes, but is not limited to, methylisothiazolinone and/or ethylhexyl glycerol.
In the invention, the essential oil is the essence of the vegetation, and 99.9 percent of the essential oil ensures the original efficacy of the plants. The compound essential oil for treating the hemorrhoids is prepared by compounding various essential oils, and the plant essential oil has the following advantages:
(1) the micromolecule is easy to absorb: the diameter of pores on human epidermis is 60-80um (1000 microns to 1 mm), and the essential oil molecule is only 1/1000, compared with 1/5000000 of human cells, so that the essential oil can permeate into skin and blood very quickly and be absorbed quickly. Compared with Chinese herbal medicines (in the form of extract, powder and the like), the permeability of the essential oil is 70 times stronger than that of the Chinese herbal medicines, so that the essential oil can quickly permeate into the deep layer of skin and blood to be absorbed, and has the effects of purifying human tissues and resisting internal bacteria. Avoids the damage of the oral drug to the liver and kidney, adopts transdermal absorption, and the potency of the drug directly permeates the focus of infection to quickly relieve the symptoms.
(2) The efficacy is strong: the essential oil is the essence of herbs, 99.9 percent of the essential oil ensures the original efficacy of the plants, and as the penetration is extremely fast and the drug property is extremely high, a small amount of the essential oil can bring the drug effect to the utmost and can take effect quickly. The efficacy of the medicine directly reaches the focus of infection, and the disease is rapidly relieved.
(3) No toxic and side effects: the essential oil is prepared by extracting natural plants, is pure and healthy, only retains the most effective components in the raw materials in the extraction process, rejects any additive and chemical components, and enables the skin to enjoy zero pollution.
(4) Is healthy and non-irritant: at present, western medicines have the problems of strong toxic and side effects, easy generation of drug resistance, drug residues and the like, and are greatly limited in clinical application. The plant essential oil becomes an excellent substitute of the antibiotic due to the characteristics of greenness, naturalness, safety, high efficiency and the like.
According to a second aspect of the invention, the invention provides a preparation method of compound essential oil for treating hemorrhoids, which comprises the following steps:
mixing rhizoma Ligustici Chuanxiong essential oil, Atractylodis rhizoma essential oil, Notopterygii rhizoma essential oil, tea tree essential oil, fructus forsythiae essential oil, rhizoma Acori Graminei essential oil, cortex Cinnamomi essential oil, optional folium fici essential oil, optional radix Sangusorbae essential oil, optional base oil and optional adjuvants uniformly to obtain the compound essential oil for treating hemorrhoid.
The preparation method of the compound essential oil for treating hemorrhoids, provided by the invention, is simple in process and convenient to operate, is suitable for industrial mass production, and can effectively improve the production efficiency.
According to a third aspect of the invention, the invention provides a use method of compound essential oil for treating hemorrhoids, which comprises the following steps:
the compound essential oil for treating hemorrhoids is smeared on an affected part and is massaged until being absorbed.
In a preferred embodiment of the invention, before the compound essential oil for treating hemorrhoids is applied to the affected part, the affected part is cleaned.
The application method of the compound essential oil for treating the hemorrhoids, provided by the invention, is simple and convenient to use, saves time and labor, can quickly take effect and fundamentally solves the pain of patients.
For further understanding of the present invention, the effects of the present invention will be described in further detail with reference to specific examples and comparative examples. All the raw materials related to the invention can be obtained commercially.
Example 1
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 1 part of ligusticum wallichii essential oil, 1 part of bighead atractylodes rhizome essential oil, 0.2 part of notopterygium root essential oil, 0.8 part of tea tree essential oil, 0.15 part of forsythia suspensa essential oil, 0.6 part of rhizoma acori graminei essential oil, 0.05 part of cinnamon essential oil and 96.2 parts of jojoba oil.
Example 2
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 3 parts of ligusticum wallichii essential oil, 0.4 part of bighead atractylodes rhizome essential oil, 0.8 part of notopterygium root essential oil, 0.2 part of tea tree essential oil, 0.75 part of forsythia suspensa essential oil, 0.1 part of rhizoma acori graminei essential oil, 0.15 part of cinnamon essential oil and 94.6 parts of jojoba oil.
Example 3
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 1.2 parts of ligusticum wallichii essential oil, 0.8 part of bighead atractylodes rhizome essential oil, 0.3 part of notopterygium root essential oil, 0.7 part of tea tree essential oil, 0.25 part of fructus forsythiae essential oil, 0.5 part of rhizoma acori graminei essential oil, 0.07 part of cinnamon essential oil and 96.18 parts of jojoba oil.
Example 4
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 2.8 parts of ligusticum wallichii essential oil, 0.5 part of bighead atractylodes rhizome essential oil, 0.7 part of notopterygium root essential oil, 0.3 part of tea tree essential oil, 0.7 part of fructus forsythiae essential oil, 0.25 part of rhizoma acori graminei essential oil, 0.13 part of cinnamon essential oil and 94.62 parts of jojoba oil.
Example 5
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 2 parts of ligusticum wallichii essential oil, 0.65 part of bighead atractylodes rhizome essential oil, 0.5 part of notopterygium root essential oil, 0.5 part of tea tree essential oil, 0.5 part of fructus forsythiae essential oil, 0.35 part of rhizoma acori graminei essential oil, 0.1 part of cinnamon essential oil and 95.4 parts of wheat germ oil.
Example 6
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 1 part of ligusticum wallichii essential oil, 1 part of bighead atractylodes rhizome essential oil, 0.8 part of notopterygium root essential oil, 0.8 part of tea tree essential oil, 0.7 part of forsythia suspensa essential oil, 0.6 part of rhizoma acori graminei essential oil, 0.1 part of cinnamon essential oil and 95 parts of sweet almond oil.
Example 7
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 2 parts of ligusticum wallichii essential oil, 0.5 part of bighead atractylodes rhizome essential oil, 0.6 part of notopterygium root essential oil, 0.6 part of tea tree essential oil, 0.5 part of fructus forsythiae essential oil, 0.5 part of rhizoma acori graminei essential oil, 0.15 part of cinnamon essential oil and 95 parts of grape seed oil.
Example 8
The embodiment provides compound essential oil for treating hemorrhoids, which comprises the following components in parts by weight: 3 parts of ligusticum wallichii essential oil, 0.4 part of bighead atractylodes rhizome essential oil, 0.4 part of notopterygium root essential oil, 0.4 part of tea tree essential oil, 0.5 part of fructus forsythiae essential oil, 0.25 part of rhizoma acori graminei essential oil, 0.05 part of cinnamon essential oil and 95 parts of jojoba oil.
Example 9
The embodiment provides compound essential oil for treating hemorrhoids, and the difference between the embodiment and the embodiment 8 is that the compound essential oil further comprises 2 parts by mass of fig leaf essential oil.
Example 10
The embodiment provides compound essential oil for treating hemorrhoids, and the difference between the embodiment and the embodiment 8 is that the compound essential oil further comprises 2 parts by mass of sanguisorba essential oil.
Example 11
The embodiment provides compound essential oil for treating hemorrhoids, and the difference between the embodiment and the embodiment 8 is that the compound essential oil further comprises 2 parts by mass of fig leaf essential oil and 2 parts by mass of sanguisorba essential oil.
Example 12
The embodiment provides a preparation method of compound essential oil for treating hemorrhoids, and the acne-removing compound essential oil preparations provided in the embodiments 1 to 9 are prepared according to the following steps:
mixing rhizoma Ligustici Chuanxiong essential oil, Atractylodis rhizoma essential oil, Notopterygii rhizoma essential oil, tea tree essential oil, fructus forsythiae essential oil, rhizoma Acori Graminei essential oil, cortex Cinnamomi essential oil, optional folium fici essential oil, optional radix Sangusorbae essential oil, optional base oil and optional adjuvants uniformly to obtain the compound essential oil for treating hemorrhoid.
Comparative example 1
The comparative example provides compound essential oil for treating hemorrhoids, and the difference between the embodiment and the embodiment 8 is that: 5 parts of ligusticum wallichii essential oil, 0.1 part of bighead atractylodes rhizome essential oil, 1 part of notopterygium root essential oil, 0.1 part of tea tree essential oil, 0.9 part of forsythia suspensa essential oil, 0.05 part of rhizoma acori graminei essential oil, 0.3 part of cinnamon essential oil and 92.55 parts of jojoba oil.
Comparative example 2
The comparative example provides compound essential oil for treating hemorrhoids, and the difference between the embodiment and the embodiment 8 is that: 0.5 part of ligusticum wallichii essential oil, 1.5 parts of bighead atractylodes rhizome essential oil, 0.1 part of notopterygium root essential oil, 1 part of tea tree essential oil, 0.15 part of fructus forsythiae essential oil, 1 part of rhizoma acori graminei essential oil, 0.02 part of cinnamon essential oil and 95.73 parts of jojoba oil.
Comparative example 3
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that ligusticum wallichii essential oil is not added.
Comparative example 4
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that no bighead atractylodes rhizome essential oil is added.
Comparative example 5
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that notopterygium root essential oil is not added.
Comparative example 6
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that tea tree essential oil is not added.
Comparative example 7
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that fructus forsythiae essential oil is not added.
Comparative example 8
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that no acorus gramineus soland essential oil is added.
Comparative example 9
The comparative example provides compound essential oil for treating hemorrhoids, and is different from the comparative example 8 in that cinnamon essential oil is not added.
Comparative example 10
The comparative example provides a hemorrhoid ointment, which is a commercially available Mayinglong hemorrhoid ointment.
The preparation method of the compound essential oil for treating hemorrhoids provided by the comparative examples 1 to 9 is the same as that of the compound essential oil for treating hemorrhoids provided by the example 8, and the details are not repeated herein.
Experimental example 1 pharmacological experiment-Effect of external application of formulation of the present invention on acetic acid induced hemorrhoid model in rat experiment 1.1 test animal
SD rats, male and female halves, body weight 200g + -20 g.
1.2 laboratory instruments, reagents
Glacial acetic acid, normal saline; electronic balance, hole puncher.
1.3 grouping and preparation method of drugs
Control group: physiological saline
Groups 1-21: examples 1-11 and comparative examples 1-10 provide medicaments for treating hemorrhoids.
1.4 Experimental procedures: 220 SD rats, half male and half female; making filter paper sheet with inner diameter of 6mm with puncher, soaking in 99.0% acetic acid solution, and placing around anus of another 220 rats respectively to make the filter paper sheet closely contact with perianal skin and mucosa, and replacing the filter paper sheet for 1 time at 0.5min and 1min for each rat; the degree of ulceration was observed on day 2, and the rats were adjusted and divided equally into 22 groups according to the difference in ulcer area and the principle of taking both male and female halves into consideration. Cleaning wounds with 1/5000 furacilin before each group of the model is made and dried with sterile gauze; 1-20 groups of compound essential oil (0.5g/ml) for treating hemorrhoids, which is provided in examples 1-11 and comparative examples 1-9, respectively, were applied; 21 groups were coated with mayinglong hemorrhoid ointment (0.25 g/set) provided in comparative example 10, and the control group was wet-dressed with absorbent cotton dipped in physiological saline of the same volume; after administration, covering with preservative film, fixing with adhesive tape, removing the dressing after 1h, and cleaning the topical part with physiological saline. The local healing of the ulcer was observed on days 3, 5, 7, 9, 11 and 13 after the administration, and the score of the ulcer was evaluated (evaluation criteria: 1 score for the presence of exudate from ulcer, 2 scores for a little exudate from ulcer, 3 scores for the presence of eschar, and 4 scores for the complete healing) and the results are shown in Table 1.
1.5 the results of the experiment are shown in the table
Table 1 effect of topical application of the invention on acetic acid induced local ulcer in rat hemorrhoid model (x ± s, n ═ 10)
Figure BDA0001810849230000131
Figure BDA0001810849230000141
As can be seen from Table 1, the ulcer integral of the compound essential oil for treating hemorrhoids provided by the groups 1-11 on the day 11 is higher than 3.5, and is obviously higher than that of the control group, which shows that the compound essential oil for treating hemorrhoids provided by the invention can obviously reduce the hemorrhoid area of rats and accelerate the healing of ulcers.
The comparison of 1-11 groups and 21 groups shows that the compound essential oil for treating hemorrhoids has slightly better effect on treating hemorrhoids than Mayilong hemorrhoids ointment, is prepared by blending natural green essential oil and base oil, has no toxic or side effect, and is healthier, safer and more environment-friendly.
As can be seen by comparing 11 groups with 8-10 groups, after the fig leaf essential oil and the garden burnet essential oil are simultaneously added into the compound essential oil for treating the haemorrhoids, the compound essential oil for treating the haemorrhoids has more remarkable curative effect through the synergistic effect of the two essential oils, and is more favorable for treating the haemorrhoids.
As can be seen by comparing 1-11 groups with 12-21 groups, the compound essential oil for treating hemorrhoids has better curative effect, can effectively reduce the hemorrhoid area of rats and accelerate the healing of ulcers by the mutual synergistic cooperation of the ligusticum wallichii essential oil, the bighead atractylodes rhizome essential oil, the notopterygium root essential oil, the tea tree essential oil, the forsythia suspense essential oil, the acorus gramineus soland essential oil, the cinnamon essential oil, the base oil, the fig leaf essential oil and the sanguisorba essential oil in specific parts by mass on the basis of the combination of the traditional Chinese medicine compatibility and the essential oil blending.
Test example 2 in vivo (human body) experiment-population trial investigation
2.1 600 hemorrhoid patients are selected, and are randomly divided into 40 cases of blank group, control group and 1-13 groups, the blank group is externally applied with physiological saline, the control group is externally applied with Mayilong hemorrhoid ointment provided by comparative example 10, the 1-13 groups are respectively treated with the compound essential oil for treating hemorrhoid provided by the embodiments 8-11 and the comparative examples 1-9 of the invention, the treatment effect of each group is observed, the cure rate and the total effective rate of each group of patients after 1 treatment course are compared, and the recurrence rate in the follow-up period of 1-1.5 years is compared, and the result is shown in Table 2.
2.2 patients with hemorrhoids all meet the diagnosis standard of hemorrhoids in the standard of curative effect of diagnosis of traditional Chinese medicine diseases published by the national administration of traditional Chinese medicine in 1994. The patients in each group have no significant difference in sex, age, disease course and hemorrhoid type,
2.3 evaluation index:
and (3) curing: the hemorrhoids atrophy, edema and pain completely disappear, and no blood seepage occurs after defecation;
improvement; all haemorrhoids prolapse, edema, pain relief, and slightly reduced hematochezia;
and (4) invalidation: no improvement was seen after the treatment.
The cure rate is 100 percent per the total number of people in each group
Total effective rate (ten better cures)/total people per group 100%.
The recurrence rate is 100% per group
2.4 results of the experiment are shown in the table
TABLE 2 comparison of treatment efficacy with relapse Rate
Figure BDA0001810849230000161
As can be seen from Table 2, the number of cured people and the number of improved people in the groups 1 to 4 are higher than those in the control group, and the recurrence rate is lower than that in the control group, which shows that the compound essential oil for treating hemorrhoids provided by the invention has a significantly better treatment effect than Mayilong hemorrhoids cream, has a significant treatment effect, can effectively treat hemorrhoids, and relieves the pain of patients with hemorrhoids.
As can be seen by comparing 4 groups with 1-3 groups, after the fig leaf essential oil and the garden burnet essential oil are simultaneously added into the compound essential oil for treating the haemorrhoids, the compound essential oil for treating the haemorrhoids has more remarkable curative effect through the synergistic effect of the two essential oils, and is more favorable for treating the haemorrhoids of patients.
As can be seen by comparing 1-4 groups with 5-13 groups, the compound essential oil for treating hemorrhoids provided by the invention is based on the combination of traditional Chinese medicine compatibility and essential oil blending, and has better curative effect by the mutual synergistic cooperation of the ligusticum wallichii essential oil, the bighead atractylodes rhizome essential oil, the notopterygium root essential oil, the tea tree essential oil, the forsythia suspense essential oil, the acorus gramineus soland essential oil, the cinnamon essential oil, the base oil, the fig leaf essential oil and the sanguisorba essential oil in specific parts by weight, so that hemorrhoids suffered by patients can be effectively treated, and the pain of the patients caused by hemorrhoids can be reduced.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (14)

1. The compound essential oil for treating hemorrhoids is characterized by comprising the following components in parts by weight: 1-3 parts of ligusticum wallichii essential oil, 0.4-1 part of bighead atractylodes rhizome essential oil, 0.2-0.8 part of notopterygium root essential oil, 0.2-0.8 part of tea tree essential oil, 0.15-0.75 part of forsythia suspensa essential oil, 0.1-0.6 part of rhizoma acori graminei essential oil and 0.05-0.15 part of cinnamon essential oil.
2. The compound essential oil for treating hemorrhoids according to claim 1 is characterized by comprising the following components in parts by weight: 1.2-2.8 parts of ligusticum wallichii essential oil, 0.5-0.8 part of bighead atractylodes rhizome essential oil, 0.3-0.7 part of notopterygium root essential oil, 0.3-0.7 part of tea tree essential oil, 0.25-0.7 part of forsythia suspense essential oil, 0.25-0.5 part of rhizoma acori graminei essential oil and 0.07-0.13 part of cinnamon essential oil.
3. The compound essential oil for treating hemorrhoids according to claim 1 is characterized by comprising the following components in parts by weight: 1.5-2.5 parts of ligusticum wallichii essential oil, 0.6-0.7 part of bighead atractylodes rhizome essential oil, 0.4-0.6 part of notopterygium root essential oil, 0.4-0.6 part of tea tree essential oil, 0.35-0.65 part of forsythia suspense essential oil, 0.3-0.4 part of rhizoma acori graminei essential oil and 0.08-0.12 part of cinnamon essential oil.
4. The compound essential oil for treating hemorrhoids as claimed in any one of claims 1 to 3, further comprising 1 to 3 parts by mass of fig leaf essential oil and 1 to 3 parts by mass of sanguisorba essential oil.
5. The compound essential oil for treating hemorrhoids as claimed in claim 4, wherein the fig leaf essential oil is 2 parts, and the sanguisorba essential oil is 2 parts.
6. The compound essential oil for treating hemorrhoids according to any one of claims 1 to 3, which is characterized by further comprising 0 to 98 parts by mass of base oil.
7. The compound essential oil for treating hemorrhoids as claimed in claim 6, wherein the base oil is at least one selected from sweet almond oil, grape seed oil, jojoba oil or wheat germ oil.
8. The compound essential oil for treating hemorrhoids as claimed in claim 7, wherein the base oil is jojoba oil.
9. The compound essential oil for treating hemorrhoids according to any one of claims 1 to 3, which is characterized by further comprising 0.5 to 2 parts by mass of an auxiliary agent.
10. The compound essential oil for treating hemorrhoids as claimed in claim 9, wherein the auxiliary agent comprises at least one of gelling agent, humectant or preservative.
11. The compound essential oil for treating hemorrhoids as claimed in claim 10, wherein the gelling agent is at least one selected from methylcellulose, hydroxypropyl methylcellulose, sodium hydroxymethyl cellulose, polyvinyl alcohol, pectin and gelatin.
12. The compound essential oil for treating hemorrhoids as claimed in claim 10, wherein the humectant is at least one selected from polyethylene glycol, propylene glycol, hexylene glycol, isoprene glycol, butylene glycol, sorbitol and glycerol.
13. The compound essential oil for treating hemorrhoids as claimed in claim 10, wherein the preservative is methyl isothiazolinone and/or ethylhexyl glycerin.
14. The preparation method of the compound essential oil for treating hemorrhoids as claimed in any one of claims 1 to 13, which comprises the following steps:
mixing rhizoma Ligustici Chuanxiong essential oil, Atractylodis rhizoma essential oil, Notopterygii rhizoma essential oil, tea tree essential oil, fructus forsythiae essential oil, rhizoma Acori Graminei essential oil, cortex Cinnamomi essential oil, optional folium fici essential oil, optional radix Sangusorbae essential oil, optional base oil and optional adjuvants uniformly to obtain the compound essential oil for treating hemorrhoid.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009047826A2 (en) * 2007-10-11 2009-04-16 Tuttofarmaco S.R.L. Pharmaceutical composition comprising sucralphate and mesalazine
CN107744543A (en) * 2017-09-13 2018-03-02 毓柔（上海）生物科技有限公司 A kind of hemorrhoid health care essential oil and hemorrhoid health wet towel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009047826A2 (en) * 2007-10-11 2009-04-16 Tuttofarmaco S.R.L. Pharmaceutical composition comprising sucralphate and mesalazine
CN107744543A (en) * 2017-09-13 2018-03-02 毓柔（上海）生物科技有限公司 A kind of hemorrhoid health care essential oil and hemorrhoid health wet towel

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