CN107335034A

CN107335034A - A kind of external medicine composition for treating leucoderma and its application

Info

Publication number: CN107335034A
Application number: CN201710543310.1A
Authority: CN
Inventors: 王浩绪
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-07-05
Filing date: 2017-07-05
Publication date: 2017-11-10

Abstract

The invention discloses a kind of external medicine composition for treating leucoderma and its application, belong to technical field of traditional Chinese medicines.External medicine composition of the present invention is made up of the following raw material：Psoralea corylifolia, the root of Dahurain angelica, Semen Cuscutae, three masts, windproof, Tong puncture vine, dark plum, three seasons are red, motherwort, Verbena officinalis, climbing groundsel, zanthoxylum nitidum, goldenrod, Myriogyne minuta, cassia twig, the root bark of shaggy-fruited dittany, asarum, the achene of Siberian cocklebur, ginger, beggar-ticks, chrysanthemum indicum, Sculellaria barbata, Chinese lobelia, screwtree root, purslane, Radix Flos Lonicerae, airpotato yam cauline leaf.The external medicine composition of the present invention can be effectively improved the efficiency of therapy of vitiligo, shorten the time of therapy of vitiligo, enough reduce the palindromia rate, slow down the psychological wound of people, lift quality of the life.The external medicine composition combination endo-medicine of the present invention, the therapeutic effect of leucoderma can be greatly promoted, its effective percentage has reached 92%~96%, and product curative effect is more notable.

Description

A kind of external medicine composition for treating leucoderma and its application

Technical field

The invention belongs to technical field of traditional Chinese medicines, is related to a kind of Chinese medicine composition, more particularly to a kind of treats the outer of leucoderma With Chinese medicine composition and its application.

Background technology

Leucoderma is a kind of common multiple posteriority pigmented dermatosis, shows as limitation or general hair property pigment takes off Lose.It is generally believed that this disease is mainly due to caused by the melanin depigmentation of skin and hair follicle.But some research cards in recent years Bright, leucoderma is not only skin pigment depigmentation disease, and other positions of body such as eye, ear chromatophore also changes, in conjunction with The anomalous variation of immunology aspect be present in this disease, illustrate leucoderma be one to invade based on skin pigment, while can also invade The systemic disease of other chromatophores of whole body.The course of disease of leucoderma is different in size, often be exposed to the sun, mental wound, acute illness Or spread rapidly under the serious stress situation such as operation.Also can slowly be in progress or interval sexual development, also can be constant steadily in the long term, at present Although also seeing the patient that indivedual small depigmentation patches voluntarily disappear, more common is that hickie tends to expand, and is increased, hair General hair style is transformed into, thus leucoderma is a kind of disease of chronic progressive, it is therefore desirable to which patients with vitiligo is finding leucoderma After to treat in time, so as to symptom management early.It is uncomfortable what leucoderma will not typically cause to the human body of patient, will not more endanger And life, its harm to human body is mainly spiritual, and serious psychological pressure and social concern can be brought to patient, so as to Reduce the quality of life of patient.

The also not enough ideal for the treatment of to leucoderma in the prior art, it is most of to be merely able to alleviate its symptom, reached as saying Case row to healing are less.For leucoderma most for the treatment of, people using by the way of traditional Chinese medicine for oral administration or combination Western medicine is administered, but use traditional Chinese medicine for oral administration due to the timeliness for the treatment of it is longer, dose it is excessive, take for a long time excessively can pair The stomach of human body affects, and influences the absorption of stomach.And western medicine is used, the recurrent of leucoderma is more frequent, The psychological unhappiness of people is caused, is less useful for the treatment of leucoderma.If combined using a kind of external medicine composition for oral administration Medicine, the treatment time limit can not only be shortened, but also the palindromia rate can be reduced, slowed down the psychological wound of people, carry Rise quality of the life.

The content of the invention

It is an object of the invention to provide one kind to shorten the treatment leucoderma time limit, reduces the treatment leucoderma of its recurrence rate External medicine composition and its application.

In order to achieve the above object, the present invention is achieved using following technical scheme.

A kind of external medicine composition for treating leucoderma, is made up of the raw material of following parts by weight：27~44 parts of psoralea corylifolia, 32~43 parts of the root of Dahurain angelica, 25~41 parts of Semen Cuscutae, 22~29 parts of three mast, windproof 20~26 parts, 17~26 parts of Tong puncture vine, dark plum 16~ 23 parts, three seasons are red 16~23 parts, 15~22 parts of motherwort, 11~18 parts of Verbena officinalis, 11~18 parts of climbing groundsel, zanthoxylum nitidum 10~ 17 parts, it is 10~17 parts of goldenrod, 10~17 parts of Myriogyne minuta, 9~19 parts of cassia twig, 9~18 parts of the root bark of shaggy-fruited dittany, 9~18 parts of asarum, grey 7~17 parts of the ears or side handles of a utensil, 7~16 parts of ginger, 6~15 parts of beggar-ticks, 0~12 part of chrysanthemum indicum, 0~11 part of Sculellaria barbata, Chinese lobelia 0~11 Part, 0~9 part of screwtree root, 0~8 part of purslane, 0~7 part of Radix Flos Lonicerae, 0~7 part of airpotato yam cauline leaf.

Further, described external medicine composition is made up of the raw material of following parts by weight：It is 32~40 parts of psoralea corylifolia, white 34~38 parts of the root of Dahurian angelica, 29~39 parts of Semen Cuscutae, 25~27 parts of three mast, windproof 22~24 parts, 19~23 parts of Tong puncture vine, dark plum 17~21 Part, three seasons are red 17~21 parts, 16~20 parts of motherwort, 12~17 parts of Verbena officinalis, 12~17 parts of climbing groundsel, zanthoxylum nitidum 9~14 It is part, 9~14 parts of goldenrod, 9~14 parts of Myriogyne minuta, 11~17 parts of cassia twig, 12~16 parts of the root bark of shaggy-fruited dittany, 12~16 parts of asarum, grey 9~15 parts of the ears or side handles of a utensil, 9~15 parts of ginger, 8~14 parts of beggar-ticks, 0~8.5 part of chrysanthemum indicum, 0~7 part of Sculellaria barbata, Chinese lobelia 0~5 Part, 0~6.5 part of screwtree root, 0~5.5 part of purslane, 0~4.5 part of Radix Flos Lonicerae, 0~3 part of airpotato yam cauline leaf.

Further, described external medicine composition is made up of the raw material of following parts by weight：It is 35.5 parts of psoralea corylifolia, white 36.5 parts of the root of Dahurian angelica, 33 parts of Semen Cuscutae, 26 parts of three mast, windproof 23 parts, 21 parts of Tong puncture vine, 19.5 parts of dark plum, three seasons are red 18 parts, motherwort 18 parts, 14.5 parts of Verbena officinalis, 14 parts of climbing groundsel, 13.5 parts of zanthoxylum nitidum, 13.5 parts of goldenrod, 13 parts of Myriogyne minuta, cassia twig 14 Part, 13 parts of the root bark of shaggy-fruited dittany, 14 parts of asarum, 12 parts of the achene of Siberian cocklebur, 11.5 parts of ginger, 10.5 parts of beggar-ticks, 7 parts of chrysanthemum indicum, Sculellaria barbata 9 Part, 7 parts of Chinese lobelia, 7 parts of screwtree root, 6 parts of purslane, 5 parts of Radix Flos Lonicerae, 4 parts of airpotato yam cauline leaf.

The preparation method of the Chinese medicine composition of described treatment leucoderma, comprises the following steps：

1) 85% ethanol of 4 times of amounts is added to extract three times psoralea corylifolia, the root of Dahurain angelica, the taste medicinal material of Semen Cuscutae three, 1.6 hours every time, Merge ethanol extract three times, filtration, it is 1.23~1.29 to reclaim ethanol and relative density is measured when being concentrated under reduced pressure into 65 DEG C Thick paste I；By three masts, windproof, Tong puncture vine, dark plum, three seasons are red, motherwort, Verbena officinalis seven flavor medicine material use steam distillation, use 7 times of water immersion 50min, distills 2~3h, collects volatile oil and the dregs of a decoction, the volatile oil mix with Benexate Hydrochloride carrier Close, obtain volatile oil inclusion B；The dregs of a decoction mix decoction with water, obtain decocting liquid A；

2) by climbing groundsel, zanthoxylum nitidum, goldenrod, Myriogyne minuta, beggar-ticks gomi herbs extracting in water twice, for the first time It is 1 that bulk drug, which is extracted, with water quality volume ratio g/ml：25~28,55 DEG C of heating stirrings 1.5 hours, filter to obtain the first filtrate；The Second extraction bulk drug is 1 with water quality volume ratio g/ml：25~28,55 DEG C of heating stirrings 65 minutes, filter to obtain the second filtrate； By cassia twig, the root bark of shaggy-fruited dittany, asarum, the achene of Siberian cocklebur, ginger gomi herbs add 5 times amount 85% alcohol refluxs extract 3 times, every time 1.6h, extract solution filtration, obtains the 3rd filtrate；Merge the first filtrate, the second filtrate and the 3rd filtrate, be concentrated under reduced pressure into raw material weight The 2/3 of amount, obtains thick paste II；

3) by seven flavor medicine materials such as chrysanthemum indicum, Sculellaria barbata, Chinese lobelia, screwtree root, purslane, Radix Flos Lonicerae, airpotato yam cauline leafs Fine powder C is ground into, crosses 100 mesh sieves, it is standby；Relative density is measured when decocting liquid A is concentrated under reduced pressure into 65 DEG C as 1.23~1.29 Thick paste III, then mixed with thick paste I, thick paste II, volatile oil inclusion B, and be selectively added fine powder C mix after obtain.

Further, the mass ratio of the volatile oil and Benexate Hydrochloride carrier is 1:0.8~1.

Further, described external medicine composition is used in combination with endo-medicine, and the topical composition is daily Smear three times, endo-medicine morning and evening respectively take once, and the time interval of external medicine composition and endo-medicine is 35~40min.

Described endo-medicine is made up of the raw material of following parts by weight：27~44 parts of psoralea corylifolia, 32~43 parts of the root of Dahurain angelica, Tu silks 25~41 parts of son, windproof 20~26 parts, 17~26 parts of Tong puncture vine, 16~23 parts of dark plum, 15~22 parts of motherwort, climbing groundsel 11~ 18 parts, 10~17 parts of zanthoxylum nitidum, 10~17 parts of goldenrod, 9~19 parts of cassia twig, 9~18 parts of asarum, 7~17 parts of the achene of Siberian cocklebur, 7~16 parts of ginger, 6~15 parts of beggar-ticks, 0~11 part of Sculellaria barbata, 0~8 part of purslane, 0~7 part of Radix Flos Lonicerae, xanthate blastostyle 0~7 part of leaf.

According to《Chinese Pharmacopoeia》And traditional Chinese medicine Historical Data Data About, the pharmacological activity of some Chinese medicines is as follows in above-mentioned formula：

Psoralea corylifolia：It is pungent, bitter, temperature.Return kidney, the spleen channel.Warming kidney and enhancing yang, gas of receiving is relievingd asthma, warming spleen and stopping diarrha；External application disappears wind nti-freckle.With Breathed heavily in the insufficiency of the kidney yang, impotence and seminal emission, enuresis frequent micturition, waist Teng's crymodynia, kidney Virtual, Diarrhoea；External application Zhi Bai Paralysis wind, alopecia areata.

Semen Cuscutae：It is pungent, sweet, put down.Return liver, kidney, the spleen channel.Tonify the liver and kidney, astringent sperm contracting urine is antiabortive, improving eyesight, antidiarrheal；External application disappears Wind nti-freckle.For kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, blurred vision tinnitus, spleen Kidney deficiency is rushed down；Externally treating leucoderma.

The root of Dahurain angelica：It is pungent, temperature.Return stomach, large intestine, lung channel.Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, declare clearing the nasal passage, eliminating dampness stops band, detumescence row Purulence, for cold headache, pain in the supra-orbital bone, runny nose of having a stuffy nose, allergic rhinitis, nasosinusitis, have a toothache, under band, sore swell and ache curative.

Tong puncture vine：It is sweet, temperature.Enter liver and kidney channel.With nourishing the liver, treat the effect of headache and dizzy, improving eyesight, kidney tonifying.Cure mainly liver kidney not Foot, soreness of waist and knee joint, blurred vision, premature ejaculation of passing out semen, frequent urination, the enuresis, hematuria, leukorrhea.

Dark plum：It is sour, puckery, put down.Return liver, spleen, lung, large intestine channel.Astringe the lung, puckery intestines, promote the production of body fluid, claming ascaris.For chronic cough of deficiency lung, chronic diarrhea Protracted dysentery, abnormal heat are quenched one's thirst, ascariasis of biliary tract vomiting stomachache.

Motherwort：It is bitter, pungent, it is slightly cold.Return liver, pericardium, bladder warp.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema are clearing heat and detoxicating.For the moon Through uncomfortable, dysmenorrhoea Amenorrhea, lochiorrhagia, oedema oliguria, sore swollen toxin.

Verbena officinalis：Hardship, it is cool.Return liver, the spleen channel.Promoting blood circulation to remove blood stasis, removing toxic substances, Li Shui, removing jaundice, preventing malaria.Yong Yu lumps in the chest and abdomen, dysmenorrhoea Amenorrhea, larynx numbness, carbuncle swells, oedema, jaundice, malaria.

Climbing groundsel：Hardship, tremble with fear.Return lung, Liver Channel.It is clearing heat and detoxicating, improving eyesight, dampness removing.For carbuncle sore tumefacting virus, cold, fever, hot eyes Swelling and pain, dysentery, skin eczema.

Zanthoxylum nitidum：For a mutation under Rutaceae Zanthoxylum.It is main with dispelling wind and removing obstruction in the meridians, expel endogenous wind to relieve convulsion, subdhing swelling and detoxicating Wind-cold-dampness arthralgia, arthralgia and myalgia, injury and bone fracture, colic, abscess of throat, have a stomach-ache, ascarid Jue suffers from abdominal pain, toothache, sore carbuncle scrofula, the medicine such as scald With value.

Goldenrod：It is pungent, bitter, it is cool.Return lung, Liver Channel.It is clearing heat and detoxicating, dispelling wind and heat from the body.For larynx numbness, acute tonsillitis, abscess of throat, Sore furuncle poison, anemopyretic cold.

Myriogyne minuta：It is pungent, temperature.Return lung passes through.Expelling cold, eliminating, clearing the nasal passage , Zhi hai.For anemofrigid headache, coughing with a lot of sputum, nasal obstruction is not It is logical, nasosinusitis runny nose.

It is windproof：It is pungent, sweet, tepor.Return bladder, liver, the spleen channel.Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion.For cold headache, wind Arthritis with fixed pain caused by dampness pain , Feng Shen itch, lockjaw.

The root bark of shaggy-fruited dittany：Hardship, tremble with fear.Returns spleen, stomach, bladder warp.Heat-clearing and damp-drying drug, wind-dispelling removing toxic substances.For damp and hot sore, yellow water is dripping, Shi Shen, rubella, mange sore leprosy, beriberoid pyretic arthralgia, jaundice.

Asarum：It is pungent, temperature.The thoughts of returning home, lung, kidney channel.Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, Wenfei of drink.For anemofrigid cold, Headache, toothache, runny nose of having a stuffy nose, allergic rhinitis, nasosinusitis, arthralgia pain due to rheumatism, sputum cough.

Cassia twig：Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.For Anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.

The achene of Siberian cocklebur：It is pungent, bitter, temperature；It is poisonous.Return lung passes through.Dispersing wind and cold, clearing the nasal passage, wind-damp dispelling.For anemofrigid headache, nasal obstruction stream Tears, allergic rhinitis, nasosinusitis, wind paralysis itch, arthritis with fixed pain caused by dampness contraction.

Ginger：It is pungent, tepor.Return lung, spleen, stomach.Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.For wind Cold flu, the cold vomiting of helmet, cold productive cough are coughed, fish and crab poisoning.

Beggar-ticks：It is sweet, light, bitter, cold nature.Liver, lung, large intestine channel.Clearing heat and detoxicating, eliminating stasis to subdue swelling, for appendicitis, kidney Inflammation, cholecystitis, enteritis, bacillary dysentery, hepatitis, peritonitis, the infection of the upper respiratory tract, tonsillitis, laryngitis, amenorrhoea, scald, poison The diseases such as snake bite, traumatic injury, skin infection, child convulsion, infantile malnutrition due to digestive disturbances or intestinalparasites.

Chrysanthemum indicum：It is bitter, pungent, it is slightly cold.Return liver, the heart channel of Hang-Shaoyin.It is clearing heat and detoxicating, purging intense heat soothing the liver.For furunculosis carbuncle swells, red eye, swell pain, Dizziness of having a headache.

Sculellaria barbata：It is pungent, bitter, tremble with fear.Return lung, liver and kidney channel.It is clearing heat and detoxicating, change tinea diuresis.For furuncle swelling toxin, abscess of throat, The pain of injury caused by falling and tumbling * oedema, jaundice, snake bite and insect sting.

Chinese lobelia：It is pungent, put down.The thoughts of returning home, small intestine, lung channel.It is clearing heat and detoxicating, inducing diuresis to remove edema.For carbuncle swells furunculosis, snake bite and insect sting, Tympanites oedema, damp and hot yellow subcutaneous ulcer, eczema wet sore.

Screwtree root：Bitter, micro-sweet, tremble with fear.It is clearing heat and detoxicating, cough-relieving.For cold and high fever, tonsillitis, sphagitis, parotitis, Measles, cough, malaria；Venomous snake bite, traumatism and bleeding, hemorrhoid, carbuncle swells furunculosis are controlled in external application.

Purslane：Acid, tremble with fear.Return liver, large intestine channel.It is clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery.For toxic-heat and blood stasis, carbuncle swells malignant boil Sore, eczema, erysipelas, snake bite and insect sting, have blood in stool, hemorrhoid blood, metrostaxis.

Honeysuckle：It is sweet, tremble with fear.Return lung, the heart, stomach.It is clearing heat and detoxicating, dispelling wind and heat from the body.For carbuncle swells furunculosis, larynx numbness, erysipelas, heat Malicious bloody flux, anemopyretic cold, warm disease heating, what the present invention selected is the root of honeysuckle.

Airpotato yam：Return liver, stomach, the heart, lung channel.Removing toxicity for detumescence, reducing phlegm and resolving masses, cooling blood and hemostasis.For Thyroid Gland Swell, lymph Tuberculosis is tied, abscess of throat, is spitted blood, spitting of blood, pertussis, cancerous swelling；Boil is controlled in external application.What the present invention selected be airpotato yam stem and Leaf.

Compared with prior art, advantageous effects of the invention：

1) external medicine composition of the invention can effectively improve the efficiency of therapy of vitiligo, shorten therapy of vitiligo Time, enough reduce the palindromia rate, slow down the psychological wound of people, lift quality of the life.The external application Chinese medicine of the present invention Composition, all medicines share, there is clearing heat and detoxicating, cooling blood and hemostasis, reducing phlegm and resolving masses, dispelling wind and removing obstruction in the meridians, purging intense heat soothing the liver, the work(of warming middle energizer to arrest vomiting Effect.

2) Chinese medicine composition preparation process of the invention is simple, important active ingredient is extracted to largerization, in raising The effective rate of utilization of traditional Chinese medicine ingredients, using Benexate Hydrochloride carrier and inclusion essential oil, effumability composition passes through in Chinese medicine After inclusion, storage rate is greatly improved, and its stability can be increased.The external medicine composition combination endo-medicine of the present invention, The therapeutic effect of leucoderma can be greatly promoted, its effective percentage has reached 92%~96%, and product curative effect is more notable.

Embodiment

Below by specific embodiment, technical scheme is further illustrated.It should be appreciated that this hair Bright embodiment is not limited to the following examples, and any formal accommodation and/or change made for the present invention all will Fall into protection scope of the present invention.

Embodiment 1

A kind of external medicine composition for treating leucoderma, is made up of the raw material of following weight：Psoralea corylifolia 27kg, the root of Dahurain angelica 32kg, Semen Cuscutae 25kg, three mast 22kg, windproof 20kg, Tong puncture vine 17kg, dark plum 16kg, three seasons red 16kg, motherwort 15kg, Verbena officinalis 11kg, climbing groundsel 11kg, zanthoxylum nitidum 10kg, goldenrod 10kg, Myriogyne minuta 10kg, cassia twig 9kg, root bark of shaggy-fruited dittany 9kg, Asarum 9kg, achene of Siberian cocklebur 7kg, ginger 7kg, beggar-ticks 6kg, chrysanthemum indicum 2kg, Sculellaria barbata 1kg, Chinese lobelia 2kg, screwtree root 1kg, Purslane 1kg, Radix Flos Lonicerae 2kg, airpotato yam cauline leaf 2kg.

A kind of preparation method of described Chinese medicine composition for treating leucoderma, comprises the following steps：

3) by seven flavor medicine materials such as chrysanthemum indicum, Sculellaria barbata, Chinese lobelia, screwtree root, purslane, Radix Flos Lonicerae, airpotato yam cauline leafs Fine powder C is ground into, crosses 100 mesh sieves, it is standby；Relative density is measured when decocting liquid A is concentrated under reduced pressure into 65 DEG C as 1.23~1.29 Thick paste III, then mixed with thick paste I, thick paste II, volatile oil inclusion B, and be optionally added fine powder C mix after obtain The Chinese medicine composition of the present invention.

The mass ratio of the volatile oil and Benexate Hydrochloride carrier is 1:0.8~1.

Described external medicine composition is used in combination with endo-medicine, and the topical composition is smeared three times daily, interior Medication thing morning and evening respectively take once, and the time interval of external medicine composition and endo-medicine is 35~40min.

Described endo-medicine is made up of the raw material of following weight：It is psoralea corylifolia 27kg, root of Dahurain angelica 32kg, Semen Cuscutae 25kg, anti- Wind 20kg, Tong puncture vine 17kg, dark plum 16kg, motherwort 15kg, climbing groundsel 11kg, zanthoxylum nitidum 10kg, goldenrod 10kg, osmanthus Branch 9kg, asarum 9kg, achene of Siberian cocklebur 7kg, ginger 7kg, beggar-ticks 6kg, Sculellaria barbata 1kg, purslane 1kg, Radix Flos Lonicerae 2kg, Huang Medicine blastostyle leaf 2kg.

The preparation method of embodiment 2~6 is with embodiment 1, its difference：Raw material components proportioning such as table 1 below.

Table 1：Raw material proportioning (the unit of embodiment 2~6：kg)

Project	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Embodiment 6
						Psoralea corylifolia	35.5	44	32	36	40
The root of Dahurain angelica	36.5	43	34	36	38
						Semen Cuscutae	33	41	29	34	39
Three masts	26	29	25	26	27
						It is windproof	23	26	22	23	24
Tong puncture vine	21	26	19	21	23
						Dark plum	19.5	23	17	19	21
Three seasons are red	18	23	17	19	21
						Motherwort	18	22	16	18	20
Verbena officinalis	14.5	18	12	15.5	17
						Climbing groundsel	14	18	12	15.5	17
Zanthoxylum nitidum	13.5	17	9	11	14
						Goldenrod	13.5	17	9	11.5	14
Myriogyne minuta	13	17	9	11.5	14
						Cassia twig	14	19	11	14	17
The root bark of shaggy-fruited dittany	13	18	12	14	16
						Asarum	14	18	12	14	16
The achene of Siberian cocklebur	12	17	9	12	15
						Ginger	11.5	16	9	12	15
Beggar-ticks	10.5	15	8	11	14
						Chrysanthemum indicum	7	12	0	5.5	8.5
Sculellaria barbata	9	11	0	3.5	7
						Chinese lobelia	7	11	0	3	5
Screwtree root	7	9	0	4	6.5
						Purslane	6	8	0	3.5	5.5
Radix Flos Lonicerae	5	7	0	2.5	4.5
						Airpotato yam cauline leaf	4	7	0	2	3

Experimental example

First, case source：Select 100 patients with vitiligo in Gansu Province Pingliang, wherein male 45, women 55, Average course of disease is 5.4 years, and patient age is between 25~45 years old.

2nd, diagnostic criteria：

It is effective：Hickie is wholly absent or white spot area reduces >=75%；Effectively：White spot area reduces, and white spot area reduces >=30%；It is invalid：Hickie is unchanged or white spot area reduces≤8%.

3rd, treatment method：The Chinese medicine composition of the present invention is prepared into paste making agent, is applied at injury, three times a day, with reference to Medicine for oral administration uses, and twice daily, and the external medicine composition of the present invention takes the course for the treatment of >=medicine for oral administration+18 days to medicine for oral administration.

4th, treatment results：Concrete result for the treatment is as shown in table 2：

Project	Patient's number	Effective number	Significant figure	Invalid number	Total effective rate (%)
						Embodiment 1	100	60	32	8	92
Embodiment 2	100	62	32	6	94
						Embodiment 3	100	61	32	7	93
Embodiment 4	100	66	28	6	94
						Embodiment 5	100	70	26	4	96
Embodiment 6	100	68	27	5	95

5th, model case：

1. patient Mr. Wang, female is 40 years old, ill when 11, Pingliang people from Zhuanglang, was diagnosed as leucoderma in hospital in 1987, adopts Smeared with the Chinese medicine composition of the present invention, aid in medicine for oral administration, treatment is fully recovered after 7 months, without recurrence after recovery from illness.

2. patient Xue, man, 59 years old, illness in November, 2016, Pingliang people from Jingning.There is dizziness without obvious inducement before half a year It is weak, occasionally there is bleeding when being brushed teeth from morning, carry out dizzy weak and bleeding gums exacerbation of symptoms within nearly 10 days, and after there is apocleisis, feed Nausea and vomiting, vomitus are gastric content, and megaloblastic anemia, PNH syndromes, white is diagnosed as in hospital in December, 2016 Purplish or white patches on the skin wind.2 months 2017 patients are smeared using the Chinese medicine composition of the present invention, aid in medicine for oral administration, and treatment is fully recovered after 2 months, is fully recovered Afterwards without recurrence.

3. connecting certain, female, 10 years old, be Pingliang Jingchuan County senior class student.The year before, leucoderma has not been luckily have, on the face neck On grown many hickies, on the face without before it is attractive in appearance, crying and screaming to go to school, and all day is all the age with a worried frown, slight, Smile is lost because of this hateful disease, straight line decline occurs in achievement.Chinese medicine in March, 2017 using the present invention Composition is smeared, and aids in medicine for oral administration, rear after treating 70 days to fully recover, and is had a broad smile on one's face, is learnt now without recurrence, little girl after recovery from illness There is interest, achievement is greatly improved.

The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.No matter from which From the point of view of a bit, the embodiment above of the invention can only all be considered the description of the invention and can not limit the present invention, right Claim indicates the scope of the present invention, therefore, any in the implication and scope suitable with claims of the present invention Change, be all considered as being included within Claims scope.

Claims

1. a kind of external medicine composition for treating leucoderma, it is characterised in that described external medicine composition is by following weight The raw material composition of part：27~44 parts of psoralea corylifolia, 32~43 parts of the root of Dahurain angelica, 25~41 parts of Semen Cuscutae, 22~29 parts of three mast, it is windproof 20~ 26 parts, 17~26 parts of Tong puncture vine, 16~23 parts of dark plum, three seasons are red 16~23 parts, 15~22 parts of motherwort, Verbena officinalis 11~18 Part, 11~18 parts of climbing groundsel, 10~17 parts of zanthoxylum nitidum, 10~17 parts of goldenrod, 10~17 parts of Myriogyne minuta, cassia twig 9~19 Part, 9~18 parts of the root bark of shaggy-fruited dittany, 9~18 parts of asarum, 7~17 parts of the achene of Siberian cocklebur, 7~16 parts of ginger, 6~15 parts of beggar-ticks, chrysanthemum indicum 0 ~12 parts, 0~11 part of Sculellaria barbata, 0~11 part of Chinese lobelia, 0~9 part of screwtree root, 0~8 part of purslane, 0~7 part of Radix Flos Lonicerae, 0~7 part of airpotato yam cauline leaf.

A kind of 2. external medicine composition for treating leucoderma according to claim 1, it is characterised in that described external application Chinese medicine composition is made up of the raw material of following parts by weight：32~40 parts of psoralea corylifolia, 34~38 parts of the root of Dahurain angelica, 29~39 parts of Semen Cuscutae, Three 25~27 parts of masts, windproof 22~24 parts, 19~23 parts of Tong puncture vine, 17~21 parts of dark plum, three seasons are red 17~21 parts, motherwort 16 ~20 parts, 12~17 parts of Verbena officinalis, 12~17 parts of climbing groundsel, 9~14 parts of zanthoxylum nitidum, 9~14 parts of goldenrod, Myriogyne minuta 9 ~14 parts, 11~17 parts of cassia twig, 12~16 parts of the root bark of shaggy-fruited dittany, 12~16 parts of asarum, 9~15 parts of the achene of Siberian cocklebur, 9~15 parts of ginger, ghost 8~14 parts of needle grass, 0~8.5 part of chrysanthemum indicum, 0~7 part of Sculellaria barbata, 0~5 part of Chinese lobelia, 0~6.5 part of screwtree root, purslane 0~ 5.5 parts, 0~4.5 part of Radix Flos Lonicerae, 0~3 part of airpotato yam cauline leaf.

A kind of 3. external medicine composition for treating leucoderma according to claim 1, it is characterised in that described external application Chinese medicine composition is made up of the raw material of following parts by weight：35.5 parts of psoralea corylifolia, 36.5 parts of the root of Dahurain angelica, 33 parts of Semen Cuscutae, 26 parts of three mast, Windproof 23 parts, 21 parts of Tong puncture vine, 19.5 parts of dark plum, three seasons are red 18 parts, 18 parts of motherwort, 14.5 parts of Verbena officinalis, 14 parts of climbing groundsel, 13.5 parts of zanthoxylum nitidum, 13.5 parts of goldenrod, 13 parts of Myriogyne minuta, 14 parts of cassia twig, 13 parts of the root bark of shaggy-fruited dittany, 14 parts of asarum, the achene of Siberian cocklebur 12 parts, 11.5 parts of ginger, 10.5 parts of beggar-ticks, 7 parts of chrysanthemum indicum, 9 parts of Sculellaria barbata, 7 parts of Chinese lobelia, 7 parts of screwtree root, purslane 6 Part, 5 parts of Radix Flos Lonicerae, 4 parts of airpotato yam cauline leaf.

A kind of 4. preparation method of external medicine composition for treating leucoderma according to claim 1, it is characterised in that Comprise the following steps：

1) add 85% ethanol of 4 times of amounts to extract three times psoralea corylifolia, the root of Dahurain angelica, the taste medicinal material of Semen Cuscutae three, 1.6 hours every time, merge Ethanol extract three times, filtration, reclaim ethanol and the thick paste that relative density is 1.23~1.29 is measured when being concentrated under reduced pressure into 65 DEG C ⅰ；By three masts, windproof, Tong puncture vine, dark plum, three seasons are red, motherwort, Verbena officinalis seven flavor medicine material use steam distillation, with 7 times Water immersion 50min, distill 2~3h, collect volatile oil and the dregs of a decoction, the volatile oil and mixed with Benexate Hydrochloride carrier, Obtain volatile oil inclusion B；The dregs of a decoction mix decoction with water, obtain decocting liquid A；

2) by climbing groundsel, zanthoxylum nitidum, goldenrod, Myriogyne minuta, beggar-ticks gomi herbs extracting in water twice, extract for the first time Bulk drug is 1 with water quality volume ratio g/ml：25~28,55 DEG C of heating stirrings 1.5 hours, filter to obtain the first filtrate；Second It is 1 that bulk drug, which is extracted, with water quality volume ratio g/ml：25~28,55 DEG C of heating stirrings 65 minutes, filter to obtain the second filtrate；By osmanthus 85% alcohol reflux that branch, the root bark of shaggy-fruited dittany, asarum, the achene of Siberian cocklebur, ginger gomi herbs add 5 times of amounts extracts 3 times, each 1.6h, carries Take liquid to filter, obtain the 3rd filtrate；Merge the first filtrate, the second filtrate and the 3rd filtrate, be concentrated under reduced pressure into the 2/ of raw material weight 3, obtain thick paste II；

3) the seven flavor medicine materials such as chrysanthemum indicum, Sculellaria barbata, Chinese lobelia, screwtree root, purslane, Radix Flos Lonicerae, airpotato yam cauline leaf are crushed Into fine powder C, 100 mesh sieves are crossed, it is standby；Measured when decocting liquid A is concentrated under reduced pressure into 65 DEG C relative density be 1.23~1.29 it is thick Cream III, then mixed with thick paste I, thick paste II, volatile oil inclusion B, and be optionally added after fine powder C is mixed and obtain this hair Bright Chinese medicine composition.

A kind of 5. preparation method of external medicine composition for treating leucoderma according to claim 4, it is characterised in that The mass ratio of the volatile oil and Benexate Hydrochloride carrier is 1:0.8~1.

A kind of 6. external medicine composition for treating leucoderma according to claim 1, it is characterised in that described external application Chinese medicine composition is used in combination with endo-medicine, and the topical composition is smeared three times daily, and endo-medicine morning and evening are each Take once, and the time interval of external medicine composition and endo-medicine is 35~40min.

7. described in the external medicine composition or claim 4 of the treatment leucoderma described in a kind of any one of claims 1 to 3 Application of the Chinese medicine composition made from method in the medicine for preparing treatment leucoderma.