CN106511770A - Traditional Chinese medicine preparation treating herpes zoster and preparing method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation treating herpes zoster and preparing method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation treating herpes zoster. The traditional Chinese medicine preparation includes indigowoad roots, honeysuckles, tulip bulbs, Chinese gall, sophora flavescens, fineleaf schizonepeta herbs, dandelions, herba violae, radix paeoniae rubra, cortex moutan, borneol, mint and cryptotaenia japonica. The invention further discloses a preparing method of the above traditional Chinese medicine. The traditional Chinese medicine preparation has the beneficial effects of being good in treatment effect, low in cost, high in cure rate, free of adverse reactions and the like in the aspect of treating herpes zoster. The traditional Chinese medicine preparation can rapidly relieve the condition of herpes zoster, the manufacturing technology is simple and convenient, the toxic and side effects are small, manufacturing is easy, raw materials are cheap, the preparing method is simple, and the traditional Chinese medicine preparation can be widely applied to clinical practice.
Description
Technical field
A kind of a kind of the present invention relates to medicinal preparation, more particularly to Chinese medicine preparation and its system for treating herpes zoster
Preparation Method.
Background technology
Herpes zoster is caused by varicella zoster virus infection, main to invade intercostal nervess and whole skin superficial
Nerve, is the cluster vesicle or pustule of unilateral distribution, and there are paroxysmal, acupuncture sample in affected part, burn sample, lightning sample pain, the traditional Chinese medical science
Claim skirt-roof dragon, herpes zoster, the disease such as treatment not in time or delay treating time, the sequela of underlying nerve pain can be left, and twined
Silk floss is not healed, and has had a strong impact on sleep and the quality of life of patient
As the Chinese medicine of China is not for a long time by patient's understanding and country's attention, so in the clinical treatment of Chinese medicine
On be ignored always, doctor trained in Western medicine doctor looks in Fan Bingxianpao hospitals, and the application of antibiotic is very universal, but effect is poor, treatment time
It is long, increase patient's pain and medical expense, in recent years, harm of the antibiotic to human body is also more and more confirmed by clinical, its
Infringement to liver and kidney is equal to Chronic Suicide.Though herpes zoster is not frequently-occurring disease, a kind of commonly encountered diseases, difficult disease, meeting
Great body and mind pain is brought to patient, the live and work quality of patient is affected.Due to China's Chinese medicine for a long time no
To paying attention to and develop, so the traditional antibiotics treatment on treatment herpes zoster, and therapeutic effect is slow, need at the soonest 2 months it is left
The right side, has delayed the state of an illness, has increased patient's pain, increased financial burden, and leave neuralgic sequela, do not recover for a long time,
Also liver, kidney have been damaged simultaneously.
China treats herpes zoster at present and is typically drug administration to release symptom and promote ulcer healing, although Jing medicines
After treatment, symptom can respite or disappearance, but need to take Western medicine in a large number while its recurrent exerbation, make patient's hardship can't bear
Speech, the side effect produced to body are very big.
The content of the invention
In order to solve the above problems, the present invention provides that a kind of toxic and side effects are little, herpes zoster is had splendid curative effect and into
The low Chinese medicine preparation of this low, relapse rate.
The technical solution used in the present invention is：A kind of Chinese medicine preparation for treating herpes zoster, each group of the Chinese medicine preparation
Part is Radix Isatidis, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss, Radix Sophorae Flavescentiss, Herba Schizonepetae, Herba Taraxaci, Herba Violae, Radix Paeoniae Rubra, Cortex Moutan, Borneolum Syntheticum.
Preferably, the ratio of weight and number of various components is, Radix Isatidis 15-30 parts, Flos Lonicerae 15-30, Pseudobulbus Cremastrae Seu Pleioness 10-20
Part, Galla Chinensiss 10-20 parts, Radix Sophorae Flavescentiss 10-20 parts, Herba Schizonepetae 10-20 parts, Herba Taraxaci 10-20 parts, Herba Violae 10-20 parts, Radix Paeoniae Rubra 10-20
Part, Cortex Moutan 5-15 parts, Borneolum Syntheticum 5-15 parts.
It is furthermore preferred that the ratio of weight and number of various components is, Radix Isatidis 15-20 parts, Flos Lonicerae 15-20, Pseudobulbus Cremastrae Seu Pleioness 10-15
Part, Galla Chinensiss 10-15 parts, Radix Sophorae Flavescentiss 10-15 parts, Herba Schizonepetae 10-15 parts, Herba Taraxaci 10-15 parts, Herba Violae 10-15 parts, Radix Paeoniae Rubra 10-15
Part, Cortex Moutan 5-10 parts, Borneolum Syntheticum 5-10 parts.
Wherein, the Chinese medicine can also add Herba Menthae and Caulis et folium cryptotaeniae japonicae, the weight of the Herba Menthae and Caulis et folium cryptotaeniae japonicae in the Chinese medicine
Measuring portion rate is：Herba Menthae 10-12 parts, Caulis et folium cryptotaeniae japonicae 8-10 parts.
Wherein, the dosage form of the Chinese medicine preparation is：Unguentum, powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of the Chinese medicine is powder, including：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, with pure and strong equivalent to 3-4 times of mixture quality
Alcohol reflux 3-5 time for 60-70% is spent, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, subsequently with positive third
Alcohol is purified 2-4 time, united extraction liquid, and recovered under reduced pressure normal propyl alcohol is simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C,
It is dried and is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% are extracted 3-4 time, and merging is carried
Liquid is taken, concentrating under reduced pressure is simultaneously dried, is ground into powder, the powder addition after crushing is 3-5 times relative to its quality and is measured
Water dissolution, static 2-4 hours are filtered, and filtrate reduced in volume is that relative density is the mastic of 1.24-1.27 and is dried at 60 DEG C,
It is ground into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively,
Merging filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the mixture quality of the 4th step
2-4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, and stirring is lower to add phase
Sodium hydroxide hydrotropy for powder quality 5%-15%, filters, plus the salt acid for adjusting pH value that concentration is 1mol/L is 5-6, mistake
Filter, precipitates standby, and filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%,
Ethanol elution is collected, precipitation determining alcohol is that the ethanol of 80-90% is extracted 2 times, is filtered, and filtrate is merged with above-mentioned eluent,
Ethanol is reclaimed, mastic is evaporated to and is spray dried to powder, sterilized, that is, obtain the powder for needing.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of the Chinese medicine is unguentum, including：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, with pure and strong equivalent to 3-4 times of mixture quality
Alcohol reflux 3-5 time for 60-70% is spent, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, subsequently with positive third
Alcohol is purified 2-4 time, united extraction liquid, and recovered under reduced pressure normal propyl alcohol is simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C,
It is dried and is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% are extracted 3-4 time, and merging is carried
Liquid is taken, concentrating under reduced pressure is simultaneously dried, is ground into powder, the powder addition after crushing is 3-5 times relative to its quality and is measured
Water dissolution, static 2-4 hours are filtered, and filtrate reduced in volume is that relative density is the mastic of 1.24-1.27 and is dried at 60 DEG C,
It is ground into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively,
Merging filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the mixture quality of the 4th step
2-4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, and stirring is lower to add phase
Sodium hydroxide hydrotropy for powder quality 5%-15%, filters, plus the salt acid for adjusting pH value that concentration is 1mol/L is 5-6, mistake
Filter, precipitates standby, and filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%,
Ethanol elution is collected, precipitation determining alcohol is that the ethanol of 80-90% is extracted 2 times, is filtered, and filtrate is merged with above-mentioned eluent,
Ethanol is reclaimed, mastic is evaporated to and is spray dried to powder, sterilized, obtain the unguentum for needing.
Radix Isatidis：Heat-clearing and toxic substances removing, measles toxin send out speckle, ulcerative carbuncle pyogenic infections, excessive noxious heat.
Flos Lonicerae：Tool removing toxic substances, antiinflammatory, sterilization, antiviral efficacy is the good medicine of heat-clearing and toxic substances removing since ancient times.
Herba Taraxaci, Herba Violae：Two medicines are often used for carbuncle that disappears dissipating bind, ulcerative carbuncle pyogenic infections simultaneously.
Herba Schizonepetae：Blood medicine, treating blood disorderss removing toxic substances, cures mainly various urticaria and ulcerative carbuncle pyogenic infections, often with Flos Lonicerae, Herba Menthae etc. increasing treatment
Effect.
Borneolum Syntheticum：Light clear fragrance, has clearing away heat and cooling blood, the work(of pain relieving.
Pseudobulbus Cremastrae Seu Pleioness：Carbuncle that disappears dissipating bind, heat-clearing and toxic substances removing.
Radix Sophorae Flavescentiss：Heat clearing and damp drying, parasite killing are antipruritic.
Herba Menthae：Antiinflammatory, analgesia, anti-itch detoxification, clearing away heat and cooling blood.
Galla Chinensiss：Convergence, hemostasis, the work(of removing toxic substances are suitable for congestion toxic swelling, Skin wet and rotten.Putrefaction removing and tissue regeneration promoting.
Radix Paeoniae Rubra：Blood circulation promoting and blood stasis dispelling, detumescence.
Cortex Moutan：Clearing away heat and cooling blood, hemostasis.
Caulis et folium cryptotaeniae japonicae antiinflammatory, removing toxic substances, promoting blood circulation, detumescence.Pneumonia is controlled, pulmonary abscess, gonorrhea, hernia, acute toothache, carbuncle furuncle swell,
Herpes zoster, skin pruritus.
Beneficial effects of the present invention：
Relative to the medicine for treating herpes zoster of the prior art, using the Chinese medicinal composition preparation energy of the present invention
Enough antiinflammatory, killing virus, analgesic therapy convergence, putrefaction-removing granulation-promoting, curative effect are fast, without any sequela, do not take medicine, do not have an injection, easy to use,
If sought medical advice in time, cure within one week or so, for herpes zoster has good effect, low cost, cure rate height, limitation
It is little, the advantages of have no adverse reaction, and targeting is strong, can alleviate rapidly the state of an illness, and toxic and side effects are little.The present invention is easy to use, and valency
Lattice are cheap, easy to use, can create preferable social value and economic interests.
Specific embodiment
Embodiment 1：
(1) a kind of Chinese medicine for treating herpes zoster, is formed by following raw material medicaments in part by weight proportioning：
- 20 parts of Radix Isatidis, Flos Lonicerae 20,15 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Galla Chinensiss, 10 parts of Radix Sophorae Flavescentiss, Herba Schizonepetae 10- parts, Herba Taraxaci
10 parts, 10 parts of Herba Violae, 10 parts of Radix Paeoniae Rubra, 5 parts of Cortex Moutan, 5 parts of Borneolum Syntheticum.
(2) preparation method：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, with pure and strong equivalent to 3-4 times of mixture quality
Alcohol reflux 3-5 time for 60-70% is spent, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, subsequently with positive third
Alcohol is purified 2-4 time, united extraction liquid, and recovered under reduced pressure normal propyl alcohol is simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C,
It is dried and is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% are extracted 3-4 time, and merging is carried
Liquid is taken, concentrating under reduced pressure is simultaneously dried, is ground into powder, the powder addition after crushing is 3-5 times relative to its quality and is measured
Water dissolution, static 2-4 hours are filtered, and filtrate reduced in volume is that relative density is the mastic of 1.24-1.27 and is dried at 60 DEG C,
It is ground into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively,
Merging filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, and stirring is lower to add phase
Sodium hydroxide hydrotropy for powder quality 5%-15%, filters, plus the salt acid for adjusting pH value that concentration is 1mol/L is 5-6, mistake
Filter, precipitates standby, and filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%,
Ethanol elution is collected, precipitation determining alcohol is that the ethanol of 80-90% is extracted 2 times, is filtered, and filtrate is merged with above-mentioned eluent,
Ethanol is reclaimed, mastic is evaporated to and is spray dried to powder, sterilized, that is, obtain the powder for needing.
Embodiment 2：
(1) a kind of Chinese medicine for treating herpes zoster, is formed by following raw material medicaments in part by weight proportioning：
- 20 parts of Radix Isatidis, Flos Lonicerae 20,15 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Galla Chinensiss, 10 parts of Radix Sophorae Flavescentiss, Herba Schizonepetae 10- parts, Herba Taraxaci
10 parts, 10 parts of Herba Violae, 10 parts of Radix Paeoniae Rubra, 5 parts of Cortex Moutan, 5 parts of Borneolum Syntheticum, 10 parts of Herba Menthae, 8 parts of Caulis et folium cryptotaeniae japonicae.
(2) preparation method：With the preparation method of embodiment 1.
Embodiment 3：
(1) a kind of Chinese medicine for treating herpes zoster, is formed by following raw material medicaments in part by weight proportioning：With embodiment 1.
(2) preparation method：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, with pure and strong equivalent to 3-4 times of mixture quality
Alcohol reflux 3-5 time for 60-70% is spent, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, subsequently with positive third
Alcohol is purified 2-4 time, united extraction liquid, and recovered under reduced pressure normal propyl alcohol is simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C,
It is dried and is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% are extracted 3-4 time, and merging is carried
Liquid is taken, concentrating under reduced pressure is simultaneously dried, is ground into powder, the powder addition after crushing is 3-5 times relative to its quality and is measured
Water dissolution, static 2-4 hours are filtered, and filtrate reduced in volume is that relative density is the mastic of 1.24-1.27 and is dried at 60 DEG C,
It is ground into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively,
Merging filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, and stirring is lower to add phase
Sodium hydroxide hydrotropy for powder quality 5%-15%, filters, plus the salt acid for adjusting pH value that concentration is 1mol/L is 5-6, mistake
Filter, precipitates standby, and filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%,
Ethanol elution is collected, precipitation determining alcohol is that the ethanol of 80-90% is extracted 2 times, is filtered, and filtrate is merged with above-mentioned eluent,
Ethanol is reclaimed, mastic is evaporated to, that is, obtains the unguentum for needing.
Embodiment 4：
(1) a kind of Chinese medicine for treating herpes zoster, is formed by following raw material medicaments in part by weight proportioning：With embodiment 2.
(2) preparation method：With embodiment 3.
Embodiment 5：
1st, long term toxicity test process：
Embodiment 1 is prepared using Wistar rats (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer)
Experimental agents calculated with dosage 1g/kg/ days by people, be that 50 times of people's effective dose are coated on rat body surface；Separately set a pair
According to group, observe the impact to rat items physiology, biochemical indicator.Test result indicate that：Experimental agents to the food-intake of rat and
Body weight increase is without impact.Do not find that to hepatic and renal function overt toxicity is acted on.To routine blood test, blood biochemistry, urine biochemistry and bone
Marrow piece etc. is showed no and significantly affects, and compares no significant difference with matched group between each group.
Embodiment 6：
The clinical treatment observation of the present invention is as follows：
(1) patient 200, wherein male 100, women 100.
(2) diagnostic criteria：
Diseased region is itched, scorching hot, pain, irregular erythema, maculopapule, the collection tufted phlysis of Semen phaseoli radiati size, bleb liquid
Clarification, around around with blush, is distributed with neural traveling, and arrangement becomes band, and between rash group, skin is normal.
(3) Therapeutic Method：1 group：Using the powder 100g as obtained in 1 preparation method of embodiment, it is divided into 50 parts, it is early daily
Morning affected part with first nitre file or for nitre file sterilization, have at blister or dense bubble and punctured with aseptic syringe needle, wipe water and pus away with aseptic cotton balls
Liquid, then with sterilization liquid disinfectant, medicated powder is dipped and rolled with aseptic swab stick be covered in affected part, being covered with sterile gauze, adhesive plaster is sticked
Patch, reduces friction as far as possible, and daily 2g 7 days is a course for the treatment of；2 groups：Using the powder 100g as obtained in 2 preparation method of embodiment, point
Into 50 parts, using method is identical with 1 group, is within 7 days a course for the treatment of；3 groups：Using the unguentum as obtained in 3 preparation method of embodiment
100g, is divided into 100 parts,；4 groups：Using the unguentum 100g as obtained in 4 preparation method of embodiment, it is divided into 100 parts, using method and 1
Group is identical, is within 7 days a course for the treatment of；A matched group is set separately.
(4) efficacy assessment standard：
Cure：Vesicle is wholly absent, and skin burns pain is wholly absent；
Take a turn for the better：Vesicle is wholly absent, and skin burns pain is not wholly absent；
It is invalid：Vesicle disappears substantially, and skin burns pain is without being clearly better.
(5) therapeutic outcome
| Group | Cure | Take a turn for the better | It is invalid |
| Matched group | 0 | 6 | 34 |
| 1 group | 35 | 5 | 0 |
| 2 groups | 38 | 2 | 0 |
| 3 groups | 36 | 4 | 0 |
| 4 groups | 39 | 1 | 0 |
Above-described embodiment is simply to illustrate that the technology design and feature of the present invention, its objective is to be to allow in the art
Those of ordinary skill will appreciate that present disclosure and implement according to this, can not be limited the scope of the invention with this.It is all
It is equivalent change or the modification according to done by the essence of present invention, all should covers in protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine preparation for treating herpes zoster, it is characterised in that：The each component of the Chinese medicine preparation is Radix Isatidis, gold silver
Flower, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss, Radix Sophorae Flavescentiss, Herba Schizonepetae, Herba Taraxaci, Herba Violae, Radix Paeoniae Rubra, Cortex Moutan, Borneolum Syntheticum.
2. Chinese medicine preparation as claimed in claim 1, it is characterised in that：The ratio of weight and number of various components is Radix Isatidis 15-30
Part, Flos Lonicerae 15-30, Pseudobulbus Cremastrae Seu Pleioness 10-20 parts, Galla Chinensiss 10-20 parts, Radix Sophorae Flavescentiss 10-20 parts, Herba Schizonepetae 10-20 parts, Herba Taraxaci 10-
20 parts, Herba Violae 10-20 parts, Radix Paeoniae Rubra 10-20 parts, Cortex Moutan 5-15 parts, Borneolum Syntheticum 5-15 parts.
3. Chinese medicine preparation as claimed in claim 1, it is characterised in that：The ratio of weight and number of various components is Radix Isatidis 15-20
Part, Flos Lonicerae 15-20, Pseudobulbus Cremastrae Seu Pleioness 10-15 parts, Galla Chinensiss 10-15 parts, Radix Sophorae Flavescentiss 10-15 parts, Herba Schizonepetae 10-15 parts, Herba Taraxaci 10-
15 parts, Herba Violae 10-15 parts, Radix Paeoniae Rubra 10-15 parts, Cortex Moutan 5-10 parts, Borneolum Syntheticum 5-10 parts.
4. the Chinese medicine preparation as any one of claim 1-3, it is characterised in that the Chinese medicine can also add Herba Menthae and
Caulis et folium cryptotaeniae japonicae, the ratio of weight and number of the Herba Menthae and Caulis et folium cryptotaeniae japonicae in the Chinese medicine is：Herba Menthae 10-12 parts, Caulis et folium cryptotaeniae japonicae 8-10 parts.
5. the Chinese medicine preparation of herpes zoster is treated as any one of claim 1-4, it is characterised in that the Chinese medicine preparation
Dosage form be：Powder, unguentum.
6. a kind of preparation method of the Chinese medicine preparation for treating herpes zoster as any one of claim 1-4, its feature exists
In：When the dosage form of the Chinese medicine is powder, including：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, and with the determining alcohol equivalent to 3-4 times of mixture quality are
The alcohol reflux of 60-70% 3-5 time, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, are subsequently carried with normal propyl alcohol
Pure 2-4 time, united extraction liquid, recovered under reduced pressure normal propyl alcohol are simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C, are dried
And it is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% is extracted 3-4 time, united extraction
Liquid, concentrating under reduced pressure are simultaneously dried, are ground into powder, and it is the 3-5 times of water measured that the powder after crushing is added relative to its quality
Dissolving, static 2-4 hours are filtered, and filtrate reduced in volume is mastic dry, powder of the relative density for 1.24-1.27 at 60 DEG C
It is broken into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively, is merged
Filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the 2- of the mixture quality of the 3rd step
4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, the lower addition of stirring relative to
The sodium hydroxide hydrotropy of powder quality 5%-15%, filters, plus concentration is 5-6 for the salt acid for adjusting pH value of 1mol/L, filters, sinks
Form sediment standby, filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%, collect second
Alcohol eluen, precipitation determining alcohol are that the ethanol of 80-90% is extracted 2 times, are filtered, and filtrate is merged with above-mentioned eluent, reclaims second
Alcohol, is evaporated to mastic and is spray dried to powder, sterilizing, that is, obtain the powder for needing.
7. a kind of preparation method of the Chinese medicine preparation of the herpes zoster as any one of claim 1-4, it is characterised in that：When
When the dosage form of the Chinese medicine is unguentum, including：
The first step, Flos Lonicerae, Pseudobulbus Cremastrae Seu Pleioness, Galla Chinensiss are mixed in proportion, and with the determining alcohol equivalent to 3-4 times of mixture quality are
The alcohol reflux of 60-70% 3-5 time, merging filtrate, concentrating under reduced pressure, drying are simultaneously ground into powder, are subsequently carried with normal propyl alcohol
Pure 2-4 time, united extraction liquid, recovered under reduced pressure normal propyl alcohol are simultaneously concentrated into mastic of the relative density for 1.24-1.27 at 60 DEG C, are dried
And it is ground into powder；
Second step, Herba Schizonepetae, Herba Taraxaci, Herba Violae, the ethanol that Radix Paeoniae Rubra determining alcohol is 80-90% is extracted 3-4 time, united extraction
Liquid, concentrating under reduced pressure are simultaneously dried, are ground into powder, and it is the 3-5 times of water measured that the powder after crushing is added relative to its quality
Dissolving, static 2-4 hours are filtered, and filtrate reduced in volume is mastic dry, powder of the relative density for 1.24-1.27 at 60 DEG C
It is broken into powder；
3rd step, remaining component is smashed and is mixed in proportion, and is added water to cook 2 times, and each 1-2 hours are filtered respectively, is merged
Filtrate, filtrate are condensed into mastic and dry, pulverize into powder, and the quality of the water for being added is the 2- of the mixture quality of the 3rd step
4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, the lower addition of stirring relative to
The sodium hydroxide hydrotropy of powder quality 5%-15%, filters, plus concentration is 5-6 for the salt acid for adjusting pH value of 1mol/L, filters, sinks
Form sediment standby, filtrate first washes decontamination with water by polyamide column, subsequently with the ethanol elution that determining alcohol is 80-90%, collect second
Alcohol eluen, precipitation determining alcohol are that the ethanol of 80-90% is extracted 2 times, are filtered, and filtrate is merged with above-mentioned eluent, reclaims second
Alcohol, is evaporated to mastic, sterilizing, that is, obtain the unguentum for needing.
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