CN106511770B - Traditional Chinese medicine preparation for treating herpes zoster and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating herpes zoster and preparation method thereof Download PDF

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CN106511770B
CN106511770B CN201611150006.2A CN201611150006A CN106511770B CN 106511770 B CN106511770 B CN 106511770B CN 201611150006 A CN201611150006 A CN 201611150006A CN 106511770 B CN106511770 B CN 106511770B
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周桂兰
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating herpes zoster, which comprises the following components in part by weight: isatis root, honeysuckle, edible tulip, Chinese gall, lightyellow sophora root, fineleaf schizonepeta herb, dandelion, bunge corydalis herb, red paeony root, tree peony bark, borneol, mint and cryptotaenia japonica. The traditional Chinese medicine preparation has the advantages of good curative effect, low cost, high cure rate, no adverse reaction and the like in the aspect of treating herpes zoster. The invention can quickly relieve the herpes zoster, has simple and convenient preparation process, small toxic and side effect, easy manufacture, cheap raw materials and simple preparation method, and can be widely applied to clinical practice.

Description

Traditional Chinese medicine preparation for treating herpes zoster and preparation method thereof
Technical Field
The invention relates to a medical preparation, in particular to a traditional Chinese medicine preparation for treating herpes zoster and a preparation method thereof.
Background
The herpes zoster is caused by varicella zoster virus infection, mainly invades intercostal nerves and superficial nerves of the whole skin, is a cluster of small blisters or pustules distributed on one side, has paroxysmal, acupuncture-like, burning-like and lightning-like pains on affected parts, is called as herpes zoster and herpes zoster in traditional Chinese medicine, can leave sequela of subcutaneous neuralgia when the treatment is not timely or delayed, is not continuous, and seriously influences the sleep and the life quality of patients
Because the Chinese medicine is not recognized by patients and is not valued by the countries for a long time, the clinical treatment of the Chinese medicine is neglected, the antibiotics are generally applied when the disease goes to hospitals and doctor doctors find western medicines, but the effect is poor, the treatment time is long, the pain and the medical cost of patients are increased, in recent years, more and more harm of the antibiotics to human bodies is clinically proved, and the damage to the liver and the kidney is equal to chronic suicide. Although the herpes zoster is not frequently encountered, a common disease and a difficult disease can bring great physical and psychological pains to patients and influence the life and the working quality of the patients. Because Chinese traditional medicine can not be paid attention and developed for a long time, the treatment of herpes zoster is generally carried out by antibiotics, the treatment effect is slow, the disease condition is delayed for about 2 months at the fastest speed, the pain of patients is aggravated, the economic burden is increased, the sequelae of neuralgia are left, the diseases are not cured for a long time, and the liver and the kidney are damaged.
At present, the herpes zoster is treated in China by taking medicines to relieve symptoms and promote ulcer healing, although the symptoms can be temporarily relieved or disappeared after the medicine treatment, a large amount of western medicines are needed to be taken while the herpes zoster is repeatedly attacked, so that patients feel uncomfortable, and the side effect on the bodies is very large.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine preparation which has small toxic and side effects, excellent curative effect on herpes zoster, low cost and low recurrence rate.
The technical scheme adopted by the invention is as follows: a traditional Chinese medicine preparation for treating herpes zoster comprises radix Isatidis, flos Lonicerae, Pseudobulbus Cremastrae seu pleiones, Galla chinensis, radix Sophorae Flavescentis, herba Schizonepetae, herba Taraxaci, herba Violae, radix Paeoniae Rubra, cortex moutan, and Borneolum Syntheticum.
Preferably, the components comprise, by weight, 15-30 parts of isatis root, 15-30 parts of honeysuckle, 10-20 parts of edible tulip, 10-20 parts of Chinese gall, 10-20 parts of radix sophorae flavescentis, 10-20 parts of schizonepeta, 10-20 parts of dandelion, 10-20 parts of bunge corydalis herb, 10-20 parts of red paeony root, 5-15 parts of cortex moutan and 5-15 parts of borneol.
More preferably, the components have the weight parts of 15-20 parts of isatis root, 15-20 parts of honeysuckle, 10-15 parts of edible tulip, 10-15 parts of Chinese gall, 10-15 parts of lightyellow sophora root, 10-15 parts of fineleaf schizonepeta herb, 10-15 parts of dandelion, 10-15 parts of bunge corydalis herb, 10-15 parts of red paeony root, 5-10 parts of cortex moutan and 5-10 parts of borneol.
The traditional Chinese medicine can also be added with mint and cryptotaenia japonica, wherein the mint and cryptotaenia japonica are in the traditional Chinese medicine in parts by weight: 10-12 parts of mint and 8-10 parts of cryptotaenia japonica.
Wherein the dosage form of the traditional Chinese medicine preparation is as follows: ointment and powder.
The invention also provides a preparation method of the traditional Chinese medicine preparation, and when the dosage form of the traditional Chinese medicine is powder, the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of that of the mixture in the fourth step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide with respect to the mass of the powder to assist dissolution under stirring, filtering, adjusting the pH value to 5-6 by adding 1mol/L hydrochloric acid, filtering, precipitating for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering ethanol, concentrating under reduced pressure to obtain paste, spray-drying the paste into powder, and sterilizing to obtain the required powder.
The invention also provides a preparation method of the traditional Chinese medicine preparation, and when the traditional Chinese medicine is in a paste form, the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of that of the mixture in the fourth step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide with respect to the mass of the powder to assist dissolution under stirring, filtering, adjusting the pH value to 5-6 by adding 1mol/L hydrochloric acid, filtering, precipitating for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering ethanol, concentrating under reduced pressure to obtain paste, spray-drying the paste into powder, and sterilizing to obtain the required paste.
Radix isatidis: clearing away heat and toxic material, treating herpes, erythema, carbuncle, sore, swelling and toxin, and exuberance of heat toxin.
Honeysuckle flower: has the efficacies of detoxification, anti-inflammation, sterilization and antivirus, and is a good medicine for clearing heat and removing toxicity since ancient times.
Dandelion, viola yedoensis: both herbs are usually indicated for resolving abscess, dissipating nodulation, abscess, sore and swelling.
Herba schizonepetae: blood-medicine also regulates blood and removes toxicity, and is mainly used for various kinds of hidden rash and carbuncle sores and pyogenic infections, and it is often combined with jin Yin Hua and Bo He to increase the curative effect.
Borneol: it is light, clear and fragrant, and has the actions of clearing heat, cooling blood and alleviating pain.
And (3) edible tulip: resolve carbuncle, dissipate nodulation, clear heat and remove toxicity.
Flavescent sophora root: clear heat and dry dampness, kill parasites and relieve itching.
Mint: diminish inflammation, relieve pain, relieve itching, remove toxicity, clear heat and cool blood.
Gallnut: astringe, stop bleeding and remove toxicity, and is suitable for treating blood stasis, swelling and toxin and skin erosion. Remove putrefaction and promote tissue regeneration.
Red peony root: promoting blood circulation, removing blood stasis, and relieving swelling.
Cortex moutan: clear heat and cool blood, stop bleeding.
The cryptotaenia japonica has the effects of diminishing inflammation, detoxifying, activating blood and reducing swelling. Treating pneumonia, lung abscess, gonorrhea, hernia, toothache due to pathogenic wind-fire, superficial infection, furuncle, herpes zoster, and skin pruritus.
The invention has the beneficial effects that:
compared with the medicine for treating herpes zoster in the prior art, the traditional Chinese medicine composition preparation disclosed by the invention can diminish inflammation, kill viruses, relieve pain, astringe, remove slough and promote granulation, is quick in curative effect, free of any sequelae, free of medicine taking and injection, convenient to use, and capable of curing herpes zoster in time if hospitalized, and has the advantages of good curative effect, low cost, high cure rate, small limitation, no adverse reaction and the like, and is strong in targeting property, capable of quickly relieving the illness state and small in toxic and side effects. The invention has the advantages of convenient use, low price and convenient use, and can create better social value and economic benefit.
Detailed Description
Example 1:
the traditional Chinese medicine for treating herpes zoster is prepared from the following raw material medicines in parts by weight:
20 parts of isatis root, 20 parts of honeysuckle, 15 parts of edible tulip, 15 parts of gallnut, 10 parts of sophora flavescens, 10 parts of schizonepeta, 10 parts of dandelion, 10 parts of bunge corydalis herb, 10 parts of red paeony root, 5 parts of cortex moutan and 5 parts of borneol.
(II) the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of the mass of the mixture in the third step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide with respect to the mass of the powder to assist dissolution under stirring, filtering, adjusting the pH value to 5-6 by adding 1mol/L hydrochloric acid, filtering, precipitating for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering ethanol, concentrating under reduced pressure to obtain paste, spray-drying the paste into powder, and sterilizing to obtain the required powder.
Example 2:
the traditional Chinese medicine for treating herpes zoster is prepared from the following raw material medicines in parts by weight:
20-20 parts of isatis root, 20 parts of honeysuckle, 15 parts of edible tulip, 15 parts of Chinese gall, 10 parts of sophora flavescens, 10-parts of schizonepeta, 10 parts of dandelion, 10 parts of bunge corydalis herb, 10 parts of red paeony root, 5 parts of cortex moutan, 5 parts of borneol, 10 parts of mint and 8 parts of cryptotaenia japonica.
(II) the preparation method comprises the following steps: the preparation method is the same as that of example 1.
Example 3:
the traditional Chinese medicine for treating herpes zoster is prepared from the following raw material medicines in parts by weight: the same as in example 1.
(II) the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of the mass of the mixture in the third step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide relative to the mass of the powder to assist dissolution under stirring, filtering, adding 1mol/L hydrochloric acid to adjust the pH value to 5-6, filtering, precipitating for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering the ethanol, and concentrating under reduced pressure to obtain the required paste.
Example 4:
the traditional Chinese medicine for treating herpes zoster is prepared from the following raw material medicines in parts by weight: the same as in example 2.
(II) the preparation method comprises the following steps: the same as in example 3.
Example 5:
1. long-term toxicity test procedure:
the experimental drug prepared in the example 1 is calculated according to the dosage of 1 g/kg/day for human by using a Wistar rat (provided by Beijing Wittingle laboratory animal technology Co., Ltd.), and the effective dosage for human is 50 times of that for human and is coated on the body surface of the rat; a control group is arranged to observe the influence on various physiological and biochemical indexes of the rat. The experimental results show that: the experimental drug has no influence on the food intake and the weight increase of the rats. No obvious toxic effect on liver and kidney functions is found. Has no obvious influence on blood routine, blood biochemistry, urine biochemistry, bone marrow tablets and the like, and has no obvious difference compared with a control group among all groups.
Example 6:
the clinical treatment observations of the present invention are as follows:
200 patients, wherein 100 men and 100 women are involved.
(II) diagnosis standard:
itching, burning, pain, irregular erythema, maculopapule, clustered small blisters of mung bean size, clear vesicular fluid, winding of areola around the periphery, and distribution in nerve running to form a belt, and the skin among the eruptions is normal.
(III) the treatment method comprises the following steps: group 1: dividing 100g of powder prepared by the preparation method of example 1 into 50 parts, disinfecting an affected part with a manite file or a nitro-replaced file every morning, puncturing a blister or a thick blister part with a sterile needle, wiping off water and pus with a sterile cotton ball, disinfecting with a disinfectant, dipping the medicinal powder with a sterile cotton stick, rolling and covering the medicinal powder on the affected part, covering with sterile gauze, sticking adhesive tapes, and reducing friction as much as possible, wherein 2g of powder is taken every day, and 7 days are a treatment course; and 2, group: dividing 100g of the powder prepared by the preparation method of example 2 into 50 parts, wherein the using method is the same as that of group 1, and 7 days is a treatment course; and 3, group: dividing 100g of the paste prepared by the preparation method of example 3 into 100 parts; 4 groups are as follows: 100g of the paste prepared by the preparation method of the embodiment 4 is divided into 100 parts, the using method is the same as that of the group 1, and 7 days are a treatment course; a control group is additionally arranged.
(IV) treatment effect evaluation criteria:
and (3) curing: the blister disappears completely, and the burning pain of the skin disappears completely;
improvement: the blister disappears completely, and the burning pain of the skin does not disappear completely;
and (4) invalidation: the blisters substantially resolved with no noticeable improvement in burning and pain of the skin.
(V) treatment outcome
Group of Cure of disease Improvement of life Invalidation
Control group 0 6 34
Group 1 35 5 0
2 groups of 38 2 0
Group 3 36 4 0
4 groups of 39 1 0
The above embodiments are only for illustrating the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention accordingly, and not to limit the protection scope of the present invention accordingly. All equivalent changes and modifications made in accordance with the spirit of the present disclosure are intended to be covered by the scope of the present disclosure.

Claims (1)

1. A traditional Chinese medicine preparation for treating herpes zoster is characterized in that: the Chinese medicinal preparation
The weight parts of each component are 15-20 parts of radix isatidis, 15-20 parts of honeysuckle, 10-15 parts of edible tulip, 10-15 parts of gallnut, 10-15 parts of radix sophorae flavescentis, 10-15 parts of schizonepeta, 10-15 parts of dandelion, 10-15 parts of bunge corydalis herb, 10-15 parts of red paeony root, 5-10 parts of cortex moutan, 5-10 parts of borneol, 10-12 parts of mint and 8-10 parts of cryptotaenia japonica; the dosage form of the traditional Chinese medicine preparation is as follows: powder and paste;
when the dosage form of the traditional Chinese medicine is powder, the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of the mass of the mixture in the third step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide with respect to the mass of the powder to assist dissolution under stirring, filtering, adjusting the pH value to 5-6 by adding 1mol/L hydrochloric acid, filtering, depositing for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering ethanol, concentrating under reduced pressure to obtain paste, spray-drying the paste into powder, and sterilizing to obtain the required powder;
when the dosage form of the traditional Chinese medicine is ointment, the preparation method comprises the following steps:
firstly, mixing honeysuckle, edible tulip and Chinese gall according to a proportion, carrying out reflux extraction for 3-5 times by using ethanol with the alcohol concentration of 60-70% which is 3-4 times of the mass of the mixture, combining filtrates, carrying out reduced pressure concentration, drying and crushing into powder, then purifying for 2-4 times by using n-propanol, combining extracting solutions, recycling the n-propanol under reduced pressure, concentrating into a paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
secondly, extracting the fineleaf schizonepeta herb, the dandelion, the bunge corydalis herb and the red paeony root for 3-4 times by using ethanol with the alcohol concentration of 80-90 percent, combining extracting solutions, concentrating under reduced pressure, drying and crushing into powder, adding water with the amount which is 3-5 times of the mass of the powder after crushing into water, standing for 2-4 hours, filtering, concentrating the filtrate under reduced pressure into paste with the relative density of 1.24-1.27 at the temperature of 60 ℃, drying and crushing into powder;
thirdly, grinding the rest components into powder, mixing the powder according to a proportion, adding water, decocting for 2 times, each time for 1-2 hours, respectively filtering, combining the filtrates, concentrating the filtrate into paste, drying, and crushing into powder, wherein the mass of the added water is 2-4 times of the mass of the mixture in the third step;
fourthly, mixing the powder, dissolving the powder in water with the mass 2-4 times of that of the mixture, adding 5-15% of sodium hydroxide with respect to the mass of the powder to assist dissolution under stirring, filtering, adjusting the pH value to 5-6 by adding 1mol/L hydrochloric acid, filtering, precipitating for later use, enabling the filtrate to pass through a polyamide column, washing off impurities by using water, eluting by using 80-90% of ethanol, collecting ethanol eluent, extracting the precipitate for 2 times by using 80-90% of ethanol, filtering, combining the filtrate and the eluent, recovering the ethanol, concentrating under reduced pressure to obtain paste, and sterilizing to obtain the required paste.
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