CN108245602B - A topical Chinese medicinal composition for treating dermatoses - Google Patents
A topical Chinese medicinal composition for treating dermatoses Download PDFInfo
- Publication number
- CN108245602B CN108245602B CN201810347942.5A CN201810347942A CN108245602B CN 108245602 B CN108245602 B CN 108245602B CN 201810347942 A CN201810347942 A CN 201810347942A CN 108245602 B CN108245602 B CN 108245602B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- coarse powder
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 208000017520 skin disease Diseases 0.000 title claims abstract description 22
- 230000000699 topical effect Effects 0.000 title claims description 24
- 239000003814 drug Substances 0.000 claims abstract description 61
- 239000000843 powder Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000009136 dragon's blood Substances 0.000 claims abstract description 18
- 238000005325 percolation Methods 0.000 claims abstract description 17
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 14
- 241001071917 Lithospermum Species 0.000 claims abstract description 14
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 235000011477 liquorice Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 238000002791 soaking Methods 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 6
- 239000011159 matrix material Substances 0.000 claims abstract description 5
- 238000007796 conventional method Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 46
- 238000002386 leaching Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 241000246044 Sophora flavescens Species 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 230000003203 everyday effect Effects 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- -1 pellicle Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 25
- 201000010099 disease Diseases 0.000 abstract description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 22
- 230000035876 healing Effects 0.000 abstract description 13
- 206010017553 Furuncle Diseases 0.000 abstract description 12
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 11
- 206010000496 acne Diseases 0.000 abstract description 11
- 230000001737 promoting effect Effects 0.000 abstract description 8
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 230000007803 itching Effects 0.000 abstract description 5
- 206010040882 skin lesion Diseases 0.000 abstract description 4
- 231100000444 skin lesion Toxicity 0.000 abstract description 4
- 206010052428 Wound Diseases 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 230000003467 diminishing effect Effects 0.000 abstract description 2
- 230000002888 effect on disease Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 230000017423 tissue regeneration Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 12
- 231100000241 scar Toxicity 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 229920000742 Cotton Polymers 0.000 description 4
- 208000028990 Skin injury Diseases 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 206010042674 Swelling Diseases 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 208000032544 Cicatrix Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000009286 sanguis draxonis Substances 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 239000003871 white petrolatum Substances 0.000 description 2
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000002910 effect on acne Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external traditional Chinese medicine composition for treating skin diseases, which is prepared by the following raw materials in parts by weight through a percolation method or a soaking method: 50-200 parts of dragon's blood, 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice; the external traditional Chinese medicine composition is concentrated into liquid extract or dried into powder, then matrix and auxiliary materials are added and mixed evenly, and the external traditional Chinese medicine preparation can be prepared according to the conventional method in the field. The traditional Chinese medicine composition and the preparation have the effects of diminishing inflammation, sterilizing, relieving itching, healing wounds and promoting tissue regeneration, can quickly relieve skin inflammatory reaction, have obvious curative effect on diseases such as acne, furuncle and the like, and have good effect on healing and recovering skin lesions caused by corresponding diseases.
Description
Technical Field
The invention relates to an external traditional Chinese medicine composition for treating skin diseases, in particular to an external traditional Chinese medicine composition for treating furuncle and acne, belonging to the technical field of external traditional Chinese medicine preparations.
Background
When the traditional Chinese medicine is used for treating inflammation and infection such as acne and furuncle, in the field of western medicine treatment, antibiotics, hormones and antifungal medicines are used, so that the side effect is large, the recurrence is easy, and scars can be formed after healing.
The traditional Chinese medicine is mainly attributed to 'internal damp-heat and external wind-evil and heat evil', and the treatment with the medicines for clearing heat and removing toxicity, dispelling wind and eliminating dampness can be said to be symptomatic medicine, but years of clinical practice shows that the simple evil-eliminating therapy can play a certain curative effect, but has three defects:
(1) although the effect is quick, the effect is obviously reduced after a plurality of days of treatment, and a long time is often needed for healing;
(2) for intractable patients, especially those who are not cured by long-term illness, the effect is not good;
(3) after healing, the skin of a patient often has obvious scars, and the skin is particularly unacceptable for patients with diseases on the face.
The applicant of the invention tries to develop the invention by using a treatment idea of strengthening body resistance as a main part and eliminating evil as an auxiliary part, and clinical application shows that the invention has obvious curative effect on acne and furuncle, has special effect on recovery of skin damage and scar after disease elimination, can quickly cure acne and furuncle after most patients (including patients who are not cured for a long time before treatment) are treated by the formula, basically recovers the skin to a normal state, and has no scar after most patients are cured, which is particularly important for patients with diseases on the face.
Disclosure of Invention
The invention aims to solve the technical problem of providing an external traditional Chinese medicine composition for treating skin diseases aiming at the defects in the prior art, the traditional Chinese medicine composition has the effects of diminishing inflammation, sterilizing, relieving itching, healing wounds and promoting tissue regeneration, can quickly relieve skin inflammatory reaction, has obvious curative effects on diseases such as acne, furuncle and the like, and has good effects on healing and recovering skin lesions caused by corresponding diseases.
In order to achieve the purpose, the invention adopts the following technical scheme:
a topical Chinese medicinal composition for treating dermatogic disease is prepared from the following raw materials by percolation or soaking method: 50-200 parts of dragon's blood, 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice.
In the technical scheme, the raw materials in parts by mass are preferably as follows: 100 parts of dragon's blood, 40 parts of lithospermum, 20 parts of sophora flavescens, 20 parts of honeysuckle and 12 parts of liquorice.
In the technical scheme, the external traditional Chinese medicine composition for treating the skin diseases is prepared by a percolation method, and the method comprises the following steps: grinding 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice into coarse powder, placing the coarse powder into a percolation cylinder, continuously adding 95 percent (volume fraction) of ethanol which is 12 times (volume: mass) of the coarse powder into the coarse powder from the upper part of the percolation cylinder, and dynamically leaching and extracting to obtain a leaching solution A; 50-200 parts of dragon's blood is dissolved in 95 percent ethanol with the volume of 4 times (volume: mass) to obtain liquid B; mixing the liquid A and the liquid B, standing for 24h, filtering, and diluting the evaporated liquid to 5-10 times of the total weight of the raw materials (volume: mass) to obtain the topical Chinese medicinal composition for treating dermatosis;
preferably, the 12 times amount refers to the volume of 95% ethanol: the mass of the coarse powder is 12: 1; the 4 times of the ethanol refers to the volume of 95% ethanol: the mass of the dragon's blood is 4: 1; the 5-10 times refers to the volume after constant volume: 5-10 of the total mass of the raw materials: 1;
preferably, the particle size of the coarse powder is 0.1-0.8 cm;
preferably, when 12 times of 95% ethanol of the coarse powder is continuously added to the coarse powder from the upper part of the percolation cylinder for dynamic leaching extraction, the 95% ethanol is added within 20-30 h;
preferably, the temperature of evaporation does not exceed 65 ℃.
In the technical scheme, the external traditional Chinese medicine composition for treating the skin diseases is prepared by a soaking method, and the method comprises the following steps: grinding 50-200 parts of dragon's blood, 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice into coarse powder, soaking the coarse powder in 95% ethanol with the amount of 10 times (volume: mass) of the coarse powder for 4-5 days, stirring the coarse powder for several times every day, filtering the mixture, and fixing the volume of the filtrate to 5-10 times (volume: mass) of the total mass of the raw materials to obtain the external traditional Chinese medicine composition for treating the skin diseases;
preferably, the 10-fold amount refers to the volume of 95% ethanol: the mass of the coarse powder is 10: 1; the 5-10 times refers to the volume after constant volume: 5-10 of the total mass of the raw materials: 1;
preferably, the particle size of the coarse powder is 0.1-0.8 cm.
The invention also provides an external traditional Chinese medicine preparation for treating skin diseases, which is prepared by concentrating the external traditional Chinese medicine composition obtained by the percolation method or the soaking method into fluid extract or drying the fluid extract into powder, then adding the matrix commonly used in the field, uniformly mixing the mixture and preparing the acceptable preparation according to the conventional method in the field;
preferably, the dosage form is any one of ointment, suppository, film agent, lotion or emulsion;
preferably, the mass ratio of the matrix to the external traditional Chinese medicine composition is 1-20: 1-10, preferably 5-10: 1 to 6;
preferably, the base is a base commonly used in the art, such as white petrolatum, lanolin, and the like.
The external traditional Chinese medicine composition for treating the skin diseases and the external traditional Chinese medicine preparation for treating the skin diseases can be used for treating the skin diseases, in particular for treating furuncle and acne. For treating furuncle, the topical Chinese medicinal composition or topical Chinese medicinal preparation is dipped in absorbent cotton and applied to affected part 2-3 times per day, with the dosage enough to uniformly cover the affected part; for treating acne, the topical Chinese medicinal composition or topical Chinese medicinal preparation is applied to affected part 1-2 times daily with absorbent cotton, and the dosage is enough to uniformly cover the affected part.
In the invention, dragon's blood is used as a monarch drug: sanguis Draxonis has effects in promoting blood circulation, dispelling blood stasis, relieving pain, stopping bleeding, healing sore, and promoting granulation. The formula mainly applies the body resistance strengthening effect of healing sore and promoting granulation, stimulates the self-repairing and healing capability of the skin, resists diseases through the autoimmune function and the hair growth function of the human body, and helps the self-repairing of skin damage.
In the invention, the lithospermum, the honeysuckle and the radix sophorae flavescentis are used as ministerial drugs: the lithospermum has the effects of clearing heat and cooling blood, promoting blood circulation and removing toxicity, promoting eruption and eliminating spots, the honeysuckle has the effects of clearing heat and removing toxicity, dispelling wind and dissipating heat, the radix sophorae flavescentis has the effects of clearing heat and drying dampness, promoting urination and relieving itching, the efficacy of the dragon blood can be brought into play by clearing heat, dampness and wind evil of a patient, and the effects of reducing pain and itching of the patient are realized together with the dragon blood.
In the invention, liquorice is used as a guiding drug. The liquorice can relieve spasm and pain, and harmonize the effects of the other drugs, so that the effects of guiding the drugs into the interior and harmonizing the drug properties are achieved in the formula, the effect of the monarch drugs and the ministerial drugs can be brought into play, and the drug stimulation is reduced.
From the perspective of modern clinical medicine and pharmacology, on one hand, the dragon blood can resist inflammation, reduce swelling, reduce purulent secretion and accelerate wound healing, and on the other hand, the dragon blood also has different degrees of inhibition effects on epidermoid pathogenic fungi and bacteria; the radix Arnebiae has antiinflammatory, antifungal, and active oxygen scavenging effects; the honeysuckle has broad-spectrum antibacterial, antiviral, antipyretic and anti-inflammatory effects; radix Sophorae Flavescentis has antiviral, antiallergic and antiinflammatory effects; glycyrrhiza also has antioxidant, antibacterial and anti-inflammatory activity. The recipe is also supported by the theory and practice of pharmacology.
The traditional Chinese medicine composition and the traditional Chinese medicine preparation provided by the invention can effectively inhibit inflammatory reaction, sterilize and relieve itching by matching the medicines, quickly cure diseases, and further promote healing and recovery of skin lesions, so that the skin lesion parts of patients are intact as before, and the traditional Chinese medicine composition and the traditional Chinese medicine preparation have no toxic or side effect.
Detailed Description
The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following descriptions:
example 1:
a topical Chinese medicinal composition for treating dermatogic disease is prepared by the following method:
taking 100g of dragon's blood, 40g of lithospermum, 20g of sophora flavescens, 20g of honeysuckle and 12g of liquorice, grinding into coarse powder (the particle size of the coarse powder is 0.1-0.8cm, the coarse powder is sieved by a second sieve, and the aperture of the second sieve is 0.85cm), uniformly mixing, soaking for 5 days by 2000ml of 95% ethanol, stirring for 3 times per day, filtering, squeezing dregs of a decoction, filtering, combining the filtrates, and fixing the volume of the filtrate to 2000ml to obtain the external traditional Chinese medicine composition for treating the skin diseases.
Example 2:
a topical Chinese medicinal composition for treating dermatogic disease is prepared by the following method:
taking 60g of lithospermum, 28g of radix sophorae flavescentis, 28g of honeysuckle and 20g of liquorice, grinding the raw materials into coarse powder (the particle size of the coarse powder is 0.1-0.8cm, the coarse powder passes through a second sieve, and the aperture of the second sieve is 0.85cm), placing the coarse powder into a percolation cylinder, continuously adding 1600ml of 95% ethanol into the coarse powder from the upper part of the percolation cylinder, and dynamically leaching and extracting, wherein the outflow speed of a percolation solution is 1-3ml/min, and the obtained leaching solution is liquid A; dissolving 200g of sanguis Draxonis in 800ml of 95% ethanol to obtain liquid B; mixing the liquid A and the liquid B, standing for 24h, filtering, concentrating the filtrate at 50 deg.C under reduced pressure to obtain liquid, and diluting with 95% ethanol to 1800ml to obtain the topical Chinese medicinal composition for treating dermatosis.
Example 3:
a topical Chinese medicinal composition for treating dermatogic disease is prepared by the following method:
80g of dragon's blood, 50g of lithospermum, 20g of sophora flavescens, 20g of honeysuckle and 15g of liquorice are taken, ground into coarse powder (the particle size of the coarse powder is 0.1-0.8cm, the coarse powder is sieved by a second sieve, and the aperture of the second sieve is 0.85cm), evenly mixed, soaked in 2000ml of 95% ethanol for 5 days, stirred for 3 times every day, filtered, and the filtrate is subjected to constant volume to 2000ml, so that the external traditional Chinese medicine composition for treating the skin diseases is obtained.
Example 4:
a topical Chinese medicinal preparation for treating dermatogic disease is prepared from the topical Chinese medicinal composition of example 2 by concentrating under reduced pressure to obtain fluid extract with density of 1.10-1.30, adding 800g white vaseline and 100g lanolin per 100g fluid extract, heating, and mixing to obtain ointment.
The clinical curative effect is as follows: 198 clinical observations of the external traditional Chinese medicine composition for treating skin diseases, which is obtained in example 1, on furuncle and swellings:
1. patient grouping
All patients are from outpatient or inpatient of hospital, and are diagnosed with furuncle and swelling according to the traditional Chinese medicine syndrome differentiation method, and 198 patients are 133 patients with age of 16-49 years in male, 65 patients with age of 17-42 years in female.
2. Method of treatment
The external traditional Chinese medicine composition in the example 1 is dipped in absorbent cotton and is smeared on the affected part for 2-3 times a day, 0.5-3ml each time, and the dosage is determined to uniformly cover the affected part for 5-15 days.
3. Criteria for therapeutic effect
And (3) curing: the disease is effectively and thoroughly treated, and the corresponding symptoms completely disappear;
the effect is shown: the disease is effectively treated, and the symptoms are obviously relieved but not completely disappeared;
and (4) invalidation: the medicine has almost no therapeutic effect on diseases, and the disease symptoms are not relieved;
and (3) relapse: the disease has recurrence phenomenon within 6-12 months after healing.
4. Results
As shown in table 1:
table 1: table for observing therapeutic effects of the topical Chinese medicinal composition obtained in example 1 on furuncle
As can be seen from table 1, the external traditional Chinese medicine composition obtained in example 1 of the present invention has an effective rate of 98.46% for treating furuncle and no recurrence; the skin injury of the cured patient is as good as the original skin injury, and no scar is left.
The clinical curative effect is two: the clinical observations of 131 cases of acne treatment by the external traditional Chinese medicine composition for treating skin diseases obtained in example 1:
1. patient grouping
All patients were from hospital outpatients or hospitalized patients, and were diagnosed with acne according to the traditional Chinese medicine syndrome differentiation method, and the number of patients was 131, wherein 59 male patients were 15-28 years old, and 72 female patients were 14-23 years old.
2. Method of treatment
The external traditional Chinese medicine composition in the example 1 is dipped in absorbent cotton and is applied to the affected part 1-2 times a day, 0.5-3ml each time, and the dosage is determined to uniformly cover the affected part for 5-40 days.
3. Criteria for therapeutic effect
And (3) curing: the disease is effectively and thoroughly treated, and the corresponding symptoms completely disappear;
the effect is shown: the disease is effectively treated, and the symptoms are obviously relieved but not completely disappeared;
and (4) invalidation: the medicine has almost no therapeutic effect on diseases, and the disease symptoms are not relieved;
and (3) relapse: the disease has recurrence phenomenon within 6-12 months after healing.
4. Results
As shown in table 2:
table 2: table for observing the therapeutic effects of the topical Chinese medicinal composition obtained in example 1 on acne
As can be seen from table 2, the external traditional Chinese medicine composition obtained in example 1 of the present invention has an effective rate of up to 100% when used for treating acne; the skin injury of the cured patient is as good as the original skin injury, and no scar is left.
The above examples are only for illustrating the technical concept and features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (8)
1. An external traditional Chinese medicine composition for treating skin diseases is characterized by being prepared from the following raw materials in parts by mass through a percolation method: 50-200 parts of dragon's blood, 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice;
when the external traditional Chinese medicine composition is prepared by a percolation method, the preparation method comprises the following steps: grinding 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice into coarse powder, placing the coarse powder into a percolation cylinder, continuously adding 95% ethanol which is 12 times of the coarse powder into the coarse powder from the upper part of the percolation cylinder, and dynamically leaching and extracting to obtain a leaching solution A; dissolving 50-200 parts of dragon's blood in 4 times of 95% ethanol to obtain liquid B; mixing the liquid A and the liquid B, standing for 24h, filtering, and metering the volume of the liquid obtained after evaporation of the filtrate to 5-10 times of the total mass of the raw materials to obtain the external traditional Chinese medicine composition for treating skin diseases;
when the external traditional Chinese medicine composition is prepared by a soaking method, the external traditional Chinese medicine composition comprises the following steps: grinding 50-200 parts of dragon's blood, 30-80 parts of lithospermum, 12-30 parts of radix sophorae flavescentis, 12-30 parts of honeysuckle and 10-30 parts of liquorice into coarse powder, soaking the coarse powder in 95% ethanol in an amount which is 10 times that of the coarse powder for 4-5 days, stirring the mixture for several times every day, filtering the mixture, and fixing the volume of the filtrate to 5-10 times of the total mass of the raw materials to obtain the external traditional Chinese medicine composition for treating the skin diseases.
2. The external traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by mass: 100 parts of dragon's blood, 40 parts of lithospermum, 20 parts of sophora flavescens, 20 parts of honeysuckle and 12 parts of liquorice.
3. The topical Chinese medicinal composition according to claim 1, wherein when the topical Chinese medicinal composition is prepared by percolation, the 12 times amount refers to the volume of 95% ethanol: the mass of the coarse powder is 12: 1; the 4 times of the ethanol refers to the volume of 95% ethanol: the mass of the dragon's blood is 4: 1; the 5-10 times refers to the volume after constant volume: 5-10 of the total mass of the raw materials: 1.
4. the topical Chinese medicinal composition according to claim 1, wherein, when the topical Chinese medicinal composition is prepared by percolation, the coarse powder has a particle size of 0.1-0.8 cm; the evaporation temperature is not more than 65 ℃; continuously adding 12 times of 95% ethanol into the coarse powder from the upper part of the percolation cylinder, and dynamically leaching and extracting, wherein the 95% ethanol is added within 20-30 h.
5. The topical Chinese medicinal composition according to claim 1, wherein when the topical Chinese medicinal composition is prepared by soaking method, the coarse powder has a particle size of 0.1-0.8 cm; the 10 times amount refers to the volume of 95% ethanol: the mass of the coarse powder is 10: 1; the 5-10 times refers to the volume after constant volume: 5-10 of the total mass of the raw materials: 1.
6. an external traditional Chinese medicine preparation for treating skin diseases is characterized in that: the externally applied traditional Chinese medicine composition of claim 1 is concentrated into fluid extract or dried into powder, then matrix commonly used in the field is added and mixed evenly, and the externally applied traditional Chinese medicine composition is prepared into acceptable dosage forms according to the conventional method in the field.
7. The topical Chinese medicinal preparation according to claim 6, characterized in that: the dosage form is any one of ointment, suppository, pellicle, lotion or emulsion.
8. The topical Chinese medicinal preparation according to claim 6, characterized in that: the mass ratio of the matrix to the external traditional Chinese medicine composition is 1-20: 1-10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810347942.5A CN108245602B (en) | 2018-04-18 | 2018-04-18 | A topical Chinese medicinal composition for treating dermatoses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810347942.5A CN108245602B (en) | 2018-04-18 | 2018-04-18 | A topical Chinese medicinal composition for treating dermatoses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108245602A CN108245602A (en) | 2018-07-06 |
| CN108245602B true CN108245602B (en) | 2021-03-09 |
Family
ID=62748441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810347942.5A Active CN108245602B (en) | 2018-04-18 | 2018-04-18 | A topical Chinese medicinal composition for treating dermatoses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108245602B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109589372A (en) * | 2019-01-02 | 2019-04-09 | 江西乾坤堂健康科技有限公司 | A kind of compound book on Chinese herbal medicine antibacterial liquid and preparation method thereof |
| CN112316012A (en) * | 2020-11-19 | 2021-02-05 | 陕西康乐实业有限公司 | Moisturizing antibacterial gel and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262943A (en) * | 1999-02-09 | 2000-08-16 | 夏进 | Skin ointment with functions of relieving inflammation, alleviating pain and inhibiting cicatrization |
| CN101073575A (en) * | 2006-05-16 | 2007-11-21 | 滕殿君 | Capsule for treating acne |
| CN102631413A (en) * | 2012-04-28 | 2012-08-15 | 董博 | Chinese medicinal composition for treating acne |
| CN103655753A (en) * | 2013-08-02 | 2014-03-26 | 上海惠林生物科技有限公司 | External-use Chinese herbal medicine quick-acting preparation for treating infant miliaria and preparation process thereof |
-
2018
- 2018-04-18 CN CN201810347942.5A patent/CN108245602B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262943A (en) * | 1999-02-09 | 2000-08-16 | 夏进 | Skin ointment with functions of relieving inflammation, alleviating pain and inhibiting cicatrization |
| CN101073575A (en) * | 2006-05-16 | 2007-11-21 | 滕殿君 | Capsule for treating acne |
| CN102631413A (en) * | 2012-04-28 | 2012-08-15 | 董博 | Chinese medicinal composition for treating acne |
| CN103655753A (en) * | 2013-08-02 | 2014-03-26 | 上海惠林生物科技有限公司 | External-use Chinese herbal medicine quick-acting preparation for treating infant miliaria and preparation process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108245602A (en) | 2018-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108186711A (en) | Promote the pharmaceutical composition of wound healing | |
| CN100360160C (en) | Medicine for treating dermatosis and its prepn | |
| CN108245602B (en) | A topical Chinese medicinal composition for treating dermatoses | |
| CN111467433A (en) | A kind of external use traditional Chinese medicine composition and ointment for promoting wound healing and preparation method thereof | |
| CN101244185A (en) | Chinese medicinal herb composition for treating skin disease and cloth containing the combination | |
| CN109674945A (en) | The Chinese medicine composition and preparation method thereof of ulcer is cured in a kind of myogenic hemostasia and detumescence analgesic | |
| CN102579650A (en) | Medicinal composition for preventing or/and treating pressure sore, as well as preparation method and application thereof | |
| CN107320519A (en) | One kind treats dermopathic ointment | |
| CN102579709A (en) | Scar preventing and removing burn oil and preparation method thereof | |
| CN111375038B (en) | Traditional Chinese medicine bath composition for treating psoriasis as well as preparation method and application thereof | |
| CN112915152B (en) | Traditional Chinese medicine mask for treating rash related to tumor molecule targeted medicine and preparation method thereof | |
| CN112972578A (en) | Ointment for treating psoriasis and preparation method thereof | |
| CN111544514A (en) | A Chinese medicinal ointment for treating burn and scald, and its preparation method | |
| CN105327244A (en) | Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating bedsores and preparing method thereof | |
| CN105560363A (en) | Traditional Chinese medicine external ointment for treating psoriasis and preparation method of traditional Chinese medicine external ointment | |
| CN111110799A (en) | Spray for treating infantile eczema and preparation method thereof | |
| CN103585330B (en) | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof | |
| CN103550510A (en) | Lotion for treating various vaginitis | |
| CN107789610A (en) | One kind treats dermopathic ointment | |
| CN116236548B (en) | Pharmaceutical composition for treating skin diseases, pharmaceutical solution and preparation method | |
| CN104398824B (en) | A kind of Chinese medicine composition for the treatment of infantile eczema | |
| CN101658583B (en) | Traditional Chinese medicine for treating cold-dampness type skin ulcer and preparation method thereof | |
| CN109045219B (en) | A kind of Hongmaocao compound external ointment for treating female rabbit mastitis | |
| CN106728820A (en) | A kind of disinfectant antipruritic ointment and preparation method thereof | |
| CN119033866A (en) | Traditional Chinese medicine composition for treating radiodermatitis as well as preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |