CN111544514A - A Chinese medicinal ointment for treating burn and scald, and its preparation method - Google Patents

A Chinese medicinal ointment for treating burn and scald, and its preparation method Download PDF

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CN111544514A
CN111544514A CN202010608827.6A CN202010608827A CN111544514A CN 111544514 A CN111544514 A CN 111544514A CN 202010608827 A CN202010608827 A CN 202010608827A CN 111544514 A CN111544514 A CN 111544514A
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parts
root
traditional chinese
chinese medicine
scalds
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高应贵
高晨峰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a traditional Chinese medicine ointment for treating burns and scalds and a preparation method thereof, wherein the traditional Chinese medicine ointment comprises the following raw materials in parts by weight: 10-20 parts of garden burnet root, 10-20 parts of rhubarb, 10-15 parts of borneol, 5-10 parts of Japanese ampelopsis, 5-8 parts of flos Loropetali, 1-2 parts of sunflower seed, 3-5 parts of ligusticum wallichii, 3-5 parts of red paeony root, 3-5 parts of radix asparagi, 20-30 parts of tea oil, 5-10 parts of peppermint oil, 1-3 parts of radix sophorae flavescentis, 2-3 parts of cortex dictamni, 1-2 parts of divaricate saposhnikovia root, 5-10 parts of common andrographis herb and 5-10 parts of houttuynia cordata. The Chinese medicinal paste is dipped with sterile cotton swab, and then uniformly applied on burn and scald wound. The traditional Chinese medicine ointment provided by the invention has obvious effects of resisting bacteria, diminishing inflammation, relieving pain, promoting the growth of new skin, accelerating wound healing and the like on burn wounds.

Description

A Chinese medicinal ointment for treating burn and scald, and its preparation method
Technical Field
The invention relates to the field of traditional Chinese medicine paste, in particular to traditional Chinese medicine paste for treating burns and scalds and a preparation method thereof.
Background
Burn and scald are one of the common clinical injuries, burn and scald are complex surgical diseases caused by the action of boiled water, boiled oil, fire, electricity or acid-base substances on human skin, and fire burn and boiled water (oil) scald are common. A mild burn or scald has red, swollen, burning or blistering epidermis; serious burns and scalds often cause serious consequences such as imbalance of water and electrolyte balance, shock, red and swollen skin tissues, ulceration, infection and the like of a human body due to the damage of skin and subcutaneous tissues of the human body, fire toxin damage to yin fluid in the body, internal attack to viscera, yin damage and yang damage. If the wound is not treated in time, the infection will not heal for a long time, which results in the generation of scars and influences the functions of limbs.
One of the central ring segments for treating burns and scalds is to prevent and treat infection of the wound surface of the burns and scalds and promote the regeneration and repair of the wound surface tissue. At present, the general exposure therapy is to keep the wound surface dry and inhibit the mass propagation of bacteria, and simultaneously, various antibiotics are used for preventing the bacteria from diffusing to the whole body through the local wound surface, but the dry environment also causes the human tissue cells to die quickly, and although the application of the antibiotics can inhibit the bacteria, the division and proliferation of the normal cells of the human body are also inhibited, so the universal exposure therapy is not beneficial to the repair and regeneration of the wound surface of the burn and scald. Another method for treating burn and scald is topical dressing therapy, which comprises applying Chinese medicinal ointment, antibiotic ointment or vaseline gauze on wound surface, and applying antibiotic by intravenous drip. The disadvantage of this treatment method is that the existing traditional Chinese medicine ointment (such as Jingwanhong ointment, etc.) has relatively weak antibacterial action, so it can not effectively inhibit bacterial reproduction, and the simple antibiotic ointment has no effect of promoting wound repair. For the wound surface in the early stage of burn and scald, due to factors such as micro thrombosis in small blood vessels, enhanced vascular permeability and the like, poor microcirculation or microcirculation disturbance is caused, so that no matter systemic administration is performed by intravenous drip or intramuscular injection, effective bactericidal concentration is difficult to form in local tissues of the burn and scald, the infection control effect is poor, wound surface ulcer can be caused, the wound surface cannot be cured for a long time, even skin grafting is finally needed, the course of disease is prolonged, and more pain and economic burden are caused for patients. In addition, strict aseptic manipulation, even aseptic isolation, is not available to ordinary hospitals or primary care units.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine ointment for treating burns and scalds and a preparation method thereof so as to solve the problems in the technical background.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials: garden burnet root, rhubarb, borneol, Japanese ampelopsis root, flos Loropetali, sunflower seed, Szechuan lovage rhizome, red paeony root, asparagus cochinchinensis, lightyellow sophora root, densefruit pittany root-bark, divaricate saposhnikovia root, common andrographis herb and heartleaf houttuynia herb.
In the technical scheme, the paint comprises the following raw materials in parts by weight: 10-20 parts of garden burnet root, 10-20 parts of rhubarb, 10-15 parts of borneol, 5-10 parts of Japanese ampelopsis, 5-8 parts of flos Loropetali, 1-2 parts of sunflower seed, 3-5 parts of ligusticum wallichii, 3-5 parts of red paeony root, 3-5 parts of radix asparagi, 20-30 parts of tea oil, 5-10 parts of peppermint oil, 1-3 parts of radix sophorae flavescentis, 2-3 parts of cortex dictamni, 1-2 parts of divaricate saposhnikovia root, 5-10 parts of common andrographis herb and 5-10 parts of houttuynia cordata.
In the technical scheme, the paint comprises the following raw materials in parts by weight: 12-17 parts of garden burnet root, 12-17 parts of rhubarb, 10-13 parts of borneol, 6-8 parts of Japanese ampelopsis, 5-7 parts of flos Loropetali, 1-2 parts of sunflower, 4-5 parts of ligusticum wallichii, 4-5 parts of red paeony root, 4-5 parts of radix asparagi, 25-30 parts of tea oil, 6-8 parts of peppermint oil, 1-2 parts of radix sophorae flavescentis, 2-3 parts of cortex dictamni, 1-2 parts of divaricate saposhnikovia root, 6-8 parts of common andrographis herb and 6-8 parts of houttuynia cordata.
In the technical scheme, the paint comprises the following raw materials in parts by weight: 15 parts of garden burnet root, 15 parts of rhubarb, 12 parts of borneol, 8 parts of Japanese ampelopsis, 6 parts of flos fetida, 1 part of sunflower flower, 4 parts of szechuan lovage rhizome, 4 parts of red paeony root, 4 parts of asparagus, 25 parts of tea oil, 8 parts of peppermint oil, 1 part of lightyellow sophora root, 3 parts of cortex dictamni, 1 part of divaricate saposhnikovia root, 8 parts of common andrographis herb and 8 parts of heartleaf houttuynia herb.
In the technical scheme, the flos Loropetali is used as the raw material.
In the technical scheme, the garden burnet root, the rhubarb, the borneol, the Japanese ampelopsis root, the flos fetidi, the sunflower, the szechuan lovage rhizome, the red paeony root, the asparagus, the lightyellow sophora root, the dittany bark, the divaricate saposhnikovia root, the common andrographis herb and the heartleaf houttuynia herb are all dry medicinal materials.
In the technical scheme, the use method of the traditional Chinese medicine ointment specifically comprises the following steps: the wound surface is dipped with sterile cotton swab and then uniformly coated for 2-3 times per day.
Wherein, the rhubarb has the effects of clearing damp-heat and purging fire, cooling blood, detoxifying, dissipating blood stasis and relieving pain;
borneol for sore and ulcer with swelling pain and unhealing after ulceration;
sanguisorba has the functions of cooling blood, stopping bleeding, healing sore and detoxifying, and has the effects of preventing and controlling infection, eliminating pain, promoting wound healing and the like. The sanguisorba contains a large amount of tannin, has stronger astringency and the function of contracting blood vessels, can reduce the permeability of capillary vessels, reduce inflammatory exudation and relieve tissue edema; the purpose of the stir-frying is mainly to enhance or generate the hemostatic effect;
ampelopsis japonica: bitter in taste and slightly cold in nature. Has the effects of clearing away heat and toxic materials, dispersing pathogen accumulation, relieving pain, promoting granulation, healing sore, promoting scab, and resisting bacteria and inflammation;
loropetali flos firewood, leaf: stop bleeding, check diarrhea, alleviate pain, promote granulation.
Yellow sunflower, slightly sweet and cool. Heat-clearing and dampness-removing, pus-expelling and pus-drawing out; flower: it is used externally to treat burns and scalds.
Ligusticum wallichii: the nature, flavor and meridian tropism, pungent and warm, enter liver, gallbladder and pericardium meridian; has the main functions of promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain.
Red peony root: the nature, flavor and meridian tropism, bitter and slightly cold; entering liver meridian; has the main efficacy of clearing heat and cooling blood, and removing blood stasis and relieving pain.
Asparagus: the nature, flavor and channel tropism, sweet, bitter and cold; entering lung and kidney meridians; has the main effects of clearing lung-heat, reducing pathogenic fire, nourishing yin and moistening dryness.
The tea oil contains tea polyphenols and tea saponin, and has effects of clearing away heat and toxic materials, relieving inflammation, relieving pain and itching.
The oleum Menthae Dementholatum has effects of clearing heat away, dispelling pathogenic wind, preventing putrefaction, relieving inflammation, relieving pain and itching; it is combined with Ku Shen, Bai Xian Pi and Fang Feng to achieve the actions of dispelling wind, promoting eruption and relieving itching.
Cortex Dictamni Radicis has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substance. It can be used for treating sore due to damp-heat pathogen, eczema, scabies, tinea, jaundice due to damp-heat pathogen, and arthralgia due to wind-damp-heat pathogen.
The common andrographis herb is cold in nature and bitter in taste, and can help to relieve swelling and pain, clear heat and diminish inflammation;
heartleaf houttuynia herb, herba houttuyniae, for clearing away heat and toxic materials; discharging pus and eliminating carbuncle; promoting urination and treating stranguria; the houttuynin (decanoyl acetaldehyde) with antibacterial and antiinflammatory effects can effectively inhibit growth of Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, etc. Can also improve immunity.
A preparation method of a traditional Chinese medicine ointment for treating burns and scalds comprises the following steps:
firstly, weighing the raw materials of the traditional Chinese medicine ointment for treating burns and scalds according to parts by weight, grinding the raw materials except tea oil, peppermint oil and borneol into superfine powder together, and grinding the borneol into superfine powder separately;
and step two, placing the weighed tea oil into a pot to boil for 3-5 minutes, pouring the fine medicinal powder obtained in the step one, uniformly stirring, cooling, adding borneol powder when the temperature is 60 ℃, fully and uniformly stirring, adding peppermint oil when the temperature is reduced to 40 ℃, and fully and uniformly stirring to obtain the traditional Chinese medicine ointment for treating burns and scalds.
In the technical scheme, in the second step, before the tea oil is added into the co-ground medicinal powder of the medicinal materials except the tea oil, the peppermint oil and the borneol, the co-ground medicinal powder is poured into a big casserole, the amount of the medicinal powder is 1 time that of water, and the mixture is decocted, filtered and the filtrate is decocted into paste.
In the technical scheme, in the second step, the tea oil is poured into the fine medicinal powder in the first step, and the mixture is stirred by a mulberry stick.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine ointment has the effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain, promoting blood circulation, removing blood stasis, removing putrefaction and promoting granulation; chinese medicinal materials such as rhubarb, common andrographis herb, heartleaf houttuynia herb and the like which have the effects of resisting bacteria, diminishing inflammation and astringing common bacteria on burn and scald wound surfaces are used; the traditional Chinese medicines of sanguisorba, borneol, ampelopsis japonica, flos Loropetali, abelmoschus manihot and the like with the functions of removing necrosis and promoting granulation, expelling pus, relieving edema and improving wound immunity are used together with the peppermint oil with the functions of easing pain and relieving itching, the peppermint oil, the sophora flavescens, the cortex dictamni and the radix sileris are used together, and the tea oil used as a matrix is matched for mutual promotion and coordination, so that the high sterilization dosage strength can be formed in wound tissues, the infection control effect is greatly improved, the function of removing necrosis and promoting granulation of the traditional Chinese medicines is utilized, the exudation is reduced, the wound surface moistening is kept, the division and proliferation of normal cells of the wound surface.
2. The traditional Chinese medicine ointment takes the tea oil as a matrix, has strong lubrication and permeability, can quickly act on the burn lesion to achieve the treatment effect, and simultaneously has the effects of clearing away heat and toxic materials, resisting inflammation and diminishing inflammation, and relieving pain and itching.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
Example 1
A traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials in parts by weight: 15 parts of garden burnet root, 15 parts of rhubarb, 12 parts of borneol, 8 parts of Japanese ampelopsis, 6 parts of flos fetida, 1 part of sunflower flower, 4 parts of szechuan lovage rhizome, 4 parts of red paeony root, 4 parts of asparagus, 25 parts of tea oil, 8 parts of peppermint oil, 1 part of lightyellow sophora root, 3 parts of cortex dictamni, 1 part of divaricate saposhnikovia root, 8 parts of common andrographis herb and 8 parts of heartleaf houttuynia herb. Further, the Loropetali flos Loropetali is used as a medicine by leaves; the garden burnet root, the rhubarb, the borneol, the Japanese ampelopsis root, the flos Loropetali, the sunflower seed, the Szechuan lovage rhizome, the red paeony root, the asparagus, the lightyellow sophora root, the dittany bark, the divaricate saposhnikovia root, the common andrographis herb and the heartleaf houttuynia herb are all dry medicinal materials. Each component of the ointment of the invention is purchased in a medicinal material store or a pharmaceutical company.
In this embodiment, the preparation method of the traditional Chinese medicine ointment for treating burns and scalds comprises the following steps:
firstly, weighing the raw materials of the traditional Chinese medicine ointment for treating burns and scalds according to parts by weight, grinding the raw materials except tea oil, peppermint oil and borneol into superfine powder together, and grinding the borneol into superfine powder separately;
and step two, placing the weighed tea oil into a pot to be boiled for 3-5 minutes, pouring the medicinal powder which is ground into the step one, uniformly stirring the medicinal powder with a mulberry stick, cooling the medicinal powder, adding borneol powder when the temperature is 60 ℃, fully and uniformly stirring the medicinal powder, adding peppermint oil when the temperature is reduced to 40 ℃, and fully and uniformly stirring the mixture to obtain the traditional Chinese medicine ointment for treating burns and scalds.
Further, in the second step, before the tea oil is added, the co-ground medicinal powder of the medicinal materials except the tea oil, the peppermint oil and the borneol is poured into a big casserole, the amount of the medicinal powder is 1 time that of the medicinal powder, the mixture is decocted and filtered, and the filtrate is decocted into paste.
Example 2
A traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials in parts by weight: 10 parts of garden burnet root, 20 parts of rhubarb, 10 parts of borneol, 10 parts of Japanese ampelopsis, 8 parts of flos fetida, 1 part of sunflower flower, 3 parts of szechuan lovage rhizome, 5 parts of red paeony root, 3 parts of asparagus, 20 parts of tea oil, 10 parts of peppermint oil, 3 parts of lightyellow sophora root, 2 parts of cortex dictamni, 2 parts of divaricate saposhnikovia root, 5 parts of common andrographis herb and 10 parts of heartleaf houttuynia herb. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds in the embodiment is similar to that in the embodiment 1.
Example 3
A traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials in parts by weight: 12 parts of garden burnet root, 17 parts of rhubarb, 13 parts of borneol, 6 parts of Japanese ampelopsis, 5 parts of flos fetida, 1 part of sunflower flower, 4 parts of szechuan lovage rhizome, 5 parts of red paeony root, 4 parts of asparagus, 25 parts of tea oil, 8 parts of peppermint oil, 1 part of lightyellow sophora root, 3 parts of cortex dictamni, 2 parts of divaricate saposhnikovia root, 6 parts of common andrographis herb and 8 parts of heartleaf houttuynia herb. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds in the embodiment is similar to that in the embodiment 1.
Example 4
A traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials in parts by weight: 17 parts of garden burnet root, 12 parts of rhubarb, 10 parts of borneol, 8 parts of Japanese ampelopsis, 7 parts of flos fetida, 2 parts of sunflower, 5 parts of szechuan lovage rhizome, 4 parts of red paeony root, 5 parts of asparagus, 30 parts of tea oil, 6 parts of peppermint oil, 1-2 parts of lightyellow sophora root, 2 parts of cortex dictamni, 1 part of divaricate saposhnikovia root, 8 parts of common andrographis herb and 6 parts of heartleaf houttuynia herb. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds in the embodiment is similar to that in the embodiment 1.
Example 5
A traditional Chinese medicine ointment for treating burns and scalds comprises the following raw materials in parts by weight: 20 parts of garden burnet root, 10 parts of rhubarb, 15 parts of borneol, 5 parts of Japanese ampelopsis, 5 parts of flos fetida, 2 parts of sunflower, 5 parts of szechuan lovage rhizome, 3 parts of red paeony root, 5 parts of asparagus, 30 parts of tea oil, 5 parts of peppermint oil, 1 part of lightyellow sophora root, 3 parts of cortex dictamni, 1 part of divaricate saposhnikovia root, 10 parts of common andrographis herb and 5 parts of heartleaf houttuynia herb. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds in the embodiment is similar to that in the embodiment 1.
Comparative example 1
This example is similar to example 5 except that andrographis paniculata and houttuynia cordata are subtracted from the formulation.
Comparative example 2
This example is similar to example 5 except that peppermint oil, sophora flavescens, cortex dictamni, ledebouriella seseloides are subtracted from the formulation.
Application example 1
70 patients with similar degree symptoms of burns and scalds and shallow II-degree burns and scalds are selected to be divided into 7 groups, and 10 patients in each group are respectively treated by the traditional Chinese medicine ointment for treating burns and scalds prepared in examples 1 to 5 and comparative examples 1 to 2.
After a period of treatment, the traditional Chinese medicine ointment for treating burns and scalds prepared in the examples 1 to 5 can be cured after generally changing the medicine for 8 to 10 days without leaving any trace; the comparative examples 1 and 2 can be cured after changing the medicine for about 15 days, and the treatment process is repeated with shallow marks.
Application example 2
1. Method of treatment
Firstly, debridement and disinfection are carried out on skin surface tissue malformed parts of burn and scald parts, the wound surfaces are washed by normal saline, then the wound surfaces are washed by antibiotic injection, the wound surfaces are wiped dry, and then sterile cotton swabs are dipped in the ointment of the invention and are evenly and thinly coated on the wound surfaces for 2-3 times per day.
2. Clinical data
975 cases of the traditional Chinese medicine ointment for treating the burns and scalds obtained in the treatment method and the example 1 are observed for treating 975 cases of middle and small-area burn and scald patients in 1 year. Wherein the age is 78 years old and 2 years old at the maximum, the male and female ratio is 3: 4, and the formula is divided into the following according to the age of children, adults and the elderly: 2-17 years old: 614 cases of; 18-55 years old: 304 cases; 56-79 years old: 57 cases. From the viewpoint of the depth of the lesion, the following 4 cases can be classified: degree I burn and scald-injury to the epidermis; the wound surface is red, speckled and dry, accompanied by burning pain. Superficial second degree burn and scald-injury to dermis and part of germinal layer; the blister has thin walls, ruddy basement and sensitive pain sensation. Deep II degree burn and scald-injury to deep dermis; the blister is thick, the basement is red and white, and the pain sense is insensitive. III degree burn and scald-injury to the whole layer of skin, subcutaneous, muscle and bone; the wound surface is thick like leather, and the pain is disappeared when the wound is locally waxed or scorched. Wherein the first degree burn and scald: 329 cases (c); superficial second degree burn and scald: 542 cases; deep second degree burn and scald: 101 cases; III degree of burn and scald: example 3.
3. Therapeutic results
(1) The curative effect standard is as follows:
the wound surface of I degree and superficial II degree is completely recovered by the epithelial cell regeneration and repair person after treatment; the deep II-degree and III-degree burned surfaces are replaced by epithelial cells or granulation tissues, and the patients with scar repair are determined to be healed;
after the treatment, the partial wound surface is repaired, and the patient who is interrupted the treatment for various reasons is determined to be improved;
if the dressing change treatment is carried out more than 10 times and the wound has no obvious repair process, the dressing change treatment is regarded as ineffective.
(2) Cure rate
The cure rate is shown in table 1:
TABLE 1
Degree of burn and scald Number of cases Recovery method Improvement of life Invalidation Cure rate
Degree I 329 329 / / 100%
Shallow II degree 532 532 / / 100%
Depth II degree 101 97 4 / 100%
III degree 13 11 1 1 92.30%
(3) Therapeutic results
Generally, after one week, the patients with I-degree burns and scalds are cured after the injured surface falls off;
patients with superficial II degree can be cured after changing the medicine for 8-10 days without leaving traces;
patients with deep II degree can be cured after changing the medicine for about 15 days generally, but 20 percent of patients are locally converted into III degree in treatment, and local pigmentation or a small amount of scars are remained.
The III-degree burn and scald patient can be cured after changing the medicine for 10-30 times (one month on average) according to the size of the wound, the necrotic tissue begins to liquefy after one week, the liquefaction can be finished in two weeks, the pulp and tooth tissue or fibrous tissue is gradually repaired after four weeks, the incidence rate of scars is about 30 percent in 10 follow-up cases, wherein the hyperplastic scars account for 10 percent, and the rest is pigmentation.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims (10)

1. A traditional Chinese medicine ointment for treating burns and scalds is characterized by comprising the following raw materials: garden burnet root, rhubarb, borneol, Japanese ampelopsis root, flos Loropetali, sunflower seed, Szechuan lovage rhizome, red paeony root, asparagus cochinchinensis, lightyellow sophora root, densefruit pittany root-bark, divaricate saposhnikovia root, common andrographis herb and heartleaf houttuynia herb.
2. The traditional Chinese medicine ointment for treating burns and scalds as claimed in claim 1, is characterized by comprising the following raw materials in parts by weight: 10-20 parts of garden burnet root, 10-20 parts of rhubarb, 10-15 parts of borneol, 5-10 parts of Japanese ampelopsis, 5-8 parts of flos Loropetali, 1-2 parts of sunflower seed, 3-5 parts of ligusticum wallichii, 3-5 parts of red paeony root, 3-5 parts of radix asparagi, 20-30 parts of tea oil, 5-10 parts of peppermint oil, 1-3 parts of radix sophorae flavescentis, 2-3 parts of cortex dictamni, 1-2 parts of divaricate saposhnikovia root, 5-10 parts of common andrographis herb and 5-10 parts of houttuynia cordata.
3. The traditional Chinese medicine ointment for treating burns and scalds as claimed in claim 2, is characterized by comprising the following raw materials in parts by weight: 12-17 parts of garden burnet root, 12-17 parts of rhubarb, 10-13 parts of borneol, 6-8 parts of Japanese ampelopsis, 5-7 parts of flos Loropetali, 1-2 parts of sunflower, 4-5 parts of ligusticum wallichii, 4-5 parts of red paeony root, 4-5 parts of radix asparagi, 25-30 parts of tea oil, 6-8 parts of peppermint oil, 1-2 parts of radix sophorae flavescentis, 2-3 parts of cortex dictamni, 1-2 parts of divaricate saposhnikovia root, 6-8 parts of common andrographis herb and 6-8 parts of houttuynia cordata.
4. The traditional Chinese medicine ointment for treating burns and scalds as claimed in claim 2, is characterized by comprising the following raw materials in parts by weight: 15 parts of garden burnet root, 15 parts of rhubarb, 12 parts of borneol, 8 parts of Japanese ampelopsis, 6 parts of flos fetida, 1 part of sunflower flower, 4 parts of szechuan lovage rhizome, 4 parts of red paeony root, 4 parts of asparagus, 25 parts of tea oil, 8 parts of peppermint oil, 1 part of lightyellow sophora root, 3 parts of cortex dictamni, 1 part of divaricate saposhnikovia root, 8 parts of common andrographis herb and 8 parts of heartleaf houttuynia herb.
5. The traditional Chinese medicine ointment for treating burns and scalds as claimed in any one of claims 1 to 4, wherein flos Loropetali is used as a leaf medicine.
6. The traditional Chinese medicine ointment for treating burns and scalds as claimed in any one of claims 1 to 4, wherein sanguisorba officinalis, rheum officinale, borneol, ampelopsis japonica, flos rosae multiflorae, abelmoschus manihot, ligusticum wallichii, radix paeoniae rubra, radix asparagi, radix sophorae flavescentis, cortex dictamni, radix sileris, andrographis paniculatae and houttuynia cordata are all dry medicinal materials.
7. The traditional Chinese medicine ointment for treating burns and scalds according to any one of claims 1 to 4, wherein the use method of the traditional Chinese medicine ointment specifically comprises the following steps: the wound surface is dipped with sterile cotton swab and then uniformly coated for 2-3 times per day.
8. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds according to claim 2, which is characterized by comprising the following steps:
weighing the raw materials of the traditional Chinese medicine ointment for treating burns and scalds in the claim 2 according to parts by weight, grinding the raw materials except the tea oil, the peppermint oil and the borneol into superfine powder together, and grinding the borneol into the superfine powder separately;
and step two, placing the tea oil weighed in the step one into a pot to be boiled for 3-5 minutes, pouring the fine medicinal powder ground in the step one, uniformly stirring and cooling, adding borneol powder when the temperature is 60 ℃, fully and uniformly stirring, adding peppermint oil when the temperature is reduced to 40 ℃, and fully and uniformly stirring to obtain the traditional Chinese medicine ointment for treating burns and scalds.
9. The preparation method of the traditional Chinese medicine ointment for treating burns and scalds as claimed in claim 8, which is characterized by comprising the following steps: in the second step, before the tea oil is added, the co-ground medicinal powder of the medicinal materials except the tea oil, the peppermint oil and the borneol is poured into a big casserole, the amount of the medicinal powder is 1 time that of the medicinal powder, the medicinal powder is decocted and filtered, and the filtrate is decocted into paste.
10. The method for preparing a Chinese medicinal ointment for treating burns and scalds according to claim 8, wherein in the second step, the tea oil is poured into the powder ground in the first step, and the mixture is stirred by a mulberry stick.
CN202010608827.6A 2020-06-30 2020-06-30 A Chinese medicinal ointment for treating burn and scald, and its preparation method Pending CN111544514A (en)

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