CN111544523A - Traditional Chinese medicine composition for treating skin ulceration and application thereof - Google Patents
Traditional Chinese medicine composition for treating skin ulceration and application thereof Download PDFInfo
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- CN111544523A CN111544523A CN202010497435.7A CN202010497435A CN111544523A CN 111544523 A CN111544523 A CN 111544523A CN 202010497435 A CN202010497435 A CN 202010497435A CN 111544523 A CN111544523 A CN 111544523A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
Abstract
The invention provides a traditional Chinese medicine composition for treating skin ulceration and application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts of angelica dahurica, 12-18 parts of rhubarb, 12-18 parts of phellodendron, 28-32 parts of bletilla striata, 18-22 parts of angelica, 18-22 parts of liquorice, 18-22 parts of dragon's blood, 28-32 parts of aloe, 18-22 parts of catechu and 5-7 parts of borneol. The pharmaceutical composition can treat bedsore, burn and scald, lower limb varicosity with ulcer, diabetic foot, disunion after incision operation, rhagadia manus et pedis, eczema, dermatitis and other skin ulcers, and has remarkable treatment effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating skin ulceration and application thereof.
Background
Skin ulceration is typically a localized skin tissue defect caused by trauma, microbial infection, tumors, circulatory and neurological dysfunction, immunologic dysfunction or congenital skin defects. Skin ulceration is a secondary lesion, and all skin lesions, infections or lesions with nodules ulcerated to a certain depth can cause skin ulceration.
Currently, topical medications are commonly used to treat skin ulcers. For example, CN 106668345a discloses a medicine for treating skin ulceration, which is prepared from honeysuckle flower, forsythia, dandelion, frankincense, myrrh, deglued antler powder, angelica, leech, earthworm, ampelopsis japonica and astragalus root by grinding the components into fine powder, mixing uniformly, sterilizing, drying and packaging. For another example, CN 105770439a is a Chinese medicinal ointment for treating skin ulceration, which comprises: wild chrysanthemum flower, thorn bark, pubescent angelica root, red peony root, bletilla striata, safflower, grassleaf sweelflag rhizome, dahurian angelica root, dragon's blood, notoginseng, native copper, Chinese angelica, gallnut, centipede, garden burnet root, unibract fritillary bulb powder, divaricate saposhnikovia root, liquorice, litharge, giant knotweed rhizome, rhubarb, dandelion, elephant skin, lightyellow sophora root, dittany bark, realgar, plant soot, cicada shell, folium callicarpae pedunculalae and borneol. Although the above drugs can treat skin ulceration to some extent, they have limited efficacy.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating skin ulceration and application thereof, and the traditional Chinese medicine composition has a remarkable curative effect in treating skin ulceration.
The traditional Chinese medicine composition for treating skin ulceration provided by the invention comprises the following raw materials in parts by weight: 10-15 parts of angelica dahurica, 12-18 parts of rhubarb, 12-18 parts of phellodendron, 28-32 parts of bletilla striata, 18-22 parts of angelica, 18-22 parts of liquorice, 18-22 parts of dragon's blood, 28-32 parts of aloe, 18-22 parts of catechu and 5-7 parts of borneol.
The main effects of the traditional Chinese medicine raw materials are as follows:
radix angelicae: has effects in eliminating disease and dampness, promoting pus discharge, promoting granulation, promoting blood circulation, and relieving pain, and can be used for treating headache, supraorbital pain, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leukorrhagia, superficial infection, pyocutaneous disease, skin pruritus, and scabies.
Rhubarb: has effects of removing food stagnation, clearing away damp heat, purging pathogenic fire, cooling blood, removing blood stasis, and removing toxic substance, and can be used for treating constipation due to excessive heat and food stagnation, hematemesis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, blood stasis, puerperal stagnation, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald.
Phellodendron bark: has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic materials, and treating sore, and can be used for treating dysentery due to damp-heat, jaundice, dark urine, pruritus vulvae, stranguria with heat, tinea pedis, atrophic debility, cramped, bone steaming, overstrain, pyocutaneous disease, pyogenic infection, eczema, and eczema.
Bletilla striata: has effects in astringing, stopping bleeding, relieving swelling, and promoting granulation, and can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, chapped skin, pulmonary tuberculosis, hemoptysis, and ulcer hemorrhage.
Chinese angelica: has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation, and can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, asthenia cold abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, and constipation due to intestinal dryness; the wine prepared with angelica can activate blood and dredge channels, and is used for treating rheumatalgia, traumatic injury and the like.
Licorice root: has effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs, and can be used for treating weakness of spleen and stomach, listlessness debilitation, cardiopalmus short breath, cough with excessive phlegm, abdominal cavity, limb spasm and pain, carbuncle swelling and sore toxin, and relieving drug toxicity and strong property.
Dragon's blood: has effects of promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, promoting granulation, and healing sore, and can be used for treating traumatic injury, heart and abdomen blood stasis and pain, traumatic hemorrhage, and unhealed skin ulcer.
Aloe vera: has purgative, liver heat clearing away, and parasite killing effects, and is used for treating constipation due to heat accumulation, headache due to liver fire, conjunctival congestion, infantile convulsion, abdominal pain due to parasitic infestation, scabies, tinea, and hemorrhoid complicated with fistula.
Catechu: has effects in promoting blood circulation, relieving pain, stopping bleeding, promoting granulation, eliminating dampness, healing sore, clearing lung-heat, and eliminating phlegm, and can be used for treating traumatic injury, traumatic hemorrhage, hematemesis, epistaxis, unhealed pyocutaneous disease, eczema, and cough due to lung heat.
Borneol: has effects of inducing resuscitation, clearing heat, removing toxic substances, improving eyesight, removing nebula, etc., can be used for treating block coma, conjunctival congestion, swelling and pain, pharyngitis, aphtha, pyocutaneous disease, swelling and pain, unhealing after ulceration, etc., and can be used for treating fever, hyperpyrexia, coma, apoplexy, phlegm syncope, epilepsy, summer-dampness, stagnation, resuscitation, sore, deafness, aphtha, swelling of teeth, carbuncle, malnutrition, hemorrhoid, conjunctival congestion, nebula, and eye covering.
The traditional Chinese medicine composition provided by the invention is reasonable in compatibility, can fully exert the drug effects of the components, ensures the medication safety, and has a remarkable synergistic effect. The Chinese medicinal composition can remove toxic substances, promote granulation, remove blood stasis, relieve pain, clear away heat and toxic materials, remove necrotic tissue, heal ulcer, repair ulcer tissue rapidly, and achieve the purpose of healing, and has remarkable curative effect in treating skin ulcer such as bedsore, burn and scald, lower limb varicosis with ulcer, diabetic foot, disunion after incision, rhagadia manus et pedis, eczema, dermatitis, etc.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12 parts of angelica dahurica, 15 parts of rhubarb, 15 parts of phellodendron, 30 parts of bletilla, 20 parts of angelica, 20 parts of liquorice, 20 parts of dragon's blood, 30 parts of aloe, 20 parts of catechu and 6 parts of borneol.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating skin ulceration.
The specific application form of the traditional Chinese medicine composition is not strictly limited, and the traditional Chinese medicine composition can be prepared into dosage forms, such as ointment and the like, which are beneficial to exerting the medicinal properties of all the components according to actual requirements.
In the present invention, the skin ulceration includes, but is not limited to, bedsore, burn and scald, varicose vein of lower limb with ulcer, diabetic foot, non-healing after incision, rhagadia manus et pedis, eczema, dermatitis, etc.
The invention also provides an ointment for treating skin ulceration, which is prepared from the traditional Chinese medicine composition.
The ointment can extract toxin and promote tissue regeneration from inside to outside, remove necrotic tissues, and gradually promote tissue regeneration and grow flesh from inside to outside until the wound is healed; after the ointment is applied, the medicine molecules directly reach the focus through the skin orifice, and the medicine molecules are permeated and absorbed to achieve transdermal administration, so that the blood vessels of the skin and the affected part are expanded, the metabolism and the regeneration are promoted, and the ointment has high curative effect on the skin infection and the ulcer and other diseases caused by intractable wounds and other various reasons.
In the present invention, the above-mentioned Chinese medicinal composition can be prepared into an ointment by a conventional method in the art. Specifically, the raw materials adopted by the ointment comprise a substrate and the traditional Chinese medicine composition, wherein the substrate comprises 800-1200 parts of vegetable oil and 160-160 parts of lipoid; preferably, the matrix comprises 1000 parts of vegetable oil and 150 parts of lipid.
Namely, the paste of the invention comprises the following raw materials in parts by weight: 10-15 parts of angelica dahurica, 12-18 parts of rhubarb, 12-18 parts of phellodendron, 28-32 parts of bletilla striata, 18-22 parts of angelica, 18-22 parts of liquorice, 18-22 parts of dragon's blood, 28-32 parts of aloe, 18-22 parts of catechu, 5-7 parts of borneol, 800-1200 parts of vegetable oil and 160 parts of lipid 140-containing material.
Preferably, the paste of the invention comprises the following raw materials in parts by weight: 12 parts of angelica dahurica, 15 parts of rhubarb, 15 parts of phellodendron, 30 parts of bletilla, 20 parts of angelica, 20 parts of liquorice, 20 parts of dragon's blood, 30 parts of aloe, 20 parts of catechu, 6 parts of borneol, 1000 parts of vegetable oil and 150 parts of lipoid.
The invention does not strictly limit the vegetable oil; specifically, the vegetable oil may be selected from at least one of sesame oil, soybean oil, peanut oil and rape oil, preferably sesame oil.
In addition, the invention is not limited to the lipids selected; specifically, the lipid may be selected from at least one of beeswax, lanolin, insect wax and whale vinegar, and more preferably beeswax.
The invention also provides a preparation method of the paste, which comprises the following steps:
grinding sanguis Draxonis, Aloe and Catechu into powder;
soaking angelica dahurica, rhubarb, phellodendron, bletilla striata, angelica and liquorice in vegetable oil according to parts by weight, decocting with slow fire, and separating dregs of a decoction;
adding the ground dragon's blood, aloe and catechu into the vegetable oil with dregs separated according to the weight portion, heating with small fire, separating dregs, adding beeswax and borneol according to the weight portion, filtering and forming ointment.
The soaking time is not particularly limited, and may be controlled to 3 to 7 days, preferably 5 days, for example. The time is favorable for fully dissolving out the effective components in the traditional Chinese medicine raw materials. In addition, the time of decocting with slow fire is not strictly limited, and the decoction with slow fire is only required to be brown.
Further, the heating time by a small fire can be controlled to be 15 to 25 minutes, preferably 20 minutes.
Further, double layers of gauze may be used for filtration.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, not only can fully exert the drug effects of all the components, but also has a remarkable synergistic effect;
2. the traditional Chinese medicine composition can rapidly repair ulcer tissues to achieve the purpose of healing, and has remarkable curative effect in treating skin ulcers such as bedsore, burn and scald, lower limb varicose vein with ulcer, diabetic foot, non-healing after incision operation, rhagadia manus et pedis, eczema, dermatitis and the like;
3. the ointment can directly reach the focus of infection through skin orifices, achieves transdermal administration through permeation and absorption, causes the expansion of blood vessels of skin and affected parts, promotes metabolism and regeneration, and has high curative effect on intractable wounds and other diseases such as skin infection and ulceration caused by various reasons.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a graph of the effect of treatment of case one;
FIG. 2 is a graph of the effect of treatment of case two;
fig. 3 is a graph showing the therapeutic effect of case three.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating skin ulceration, which comprises the following raw materials in parts by weight: 12 parts of angelica dahurica, 15 parts of rhubarb, 15 parts of phellodendron, 30 parts of bletilla, 20 parts of angelica, 20 parts of liquorice, 20 parts of dragon's blood, 30 parts of aloe, 20 parts of catechu and 6 parts of borneol.
Example 2
The ointment for treating skin ulceration provided by the embodiment comprises the traditional Chinese medicine composition of the embodiment 1.
Specifically, the ointment for treating skin ulceration provided by the embodiment comprises the following raw materials in parts by weight: 12 parts of angelica dahurica, 15 parts of rhubarb, 15 parts of phellodendron, 30 parts of bletilla, 20 parts of angelica, 20 parts of liquorice, 20 parts of dragon's blood, 30 parts of aloe, 20 parts of catechu, 6 parts of borneol, 1000 g of sesame oil and 150 g of beeswax.
The preparation method of the paste of this example is as follows:
soaking angelica dahurica, rhubarb, phellodendron, bletilla striata, angelica and liquorice in sesame oil for 5 days according to the parts by weight; meanwhile, the dragon's blood, the aloe and the catechu are ground into powder for standby.
Decocting oleum Sesami soaked with Chinese medicinal materials with slow fire until the medicine is brown, separating to obtain residue, adding powders of sanguis Draxonis, Aloe and Catechu, heating with slow fire for 20 min after it emerges from the oil surface, filtering to remove residue, adding Cera flava and Borneolum Syntheticum in parts by weight, filtering with double-layer gauze, and making into ointment.
Example 3
The embodiment provides an ointment for treating skin ulceration, which comprises the following raw materials in parts by weight: 10 parts of angelica dahurica, 17 parts of rhubarb, 13 parts of phellodendron, 32 parts of bletilla, 20 parts of angelica, 18 parts of liquorice, 20 parts of dragon's blood, 28 parts of aloe, 19 parts of catechu, 5 parts of borneol, 1000 g of sesame oil and 150 g of beeswax.
The preparation method of the paste of this example is as follows:
soaking angelica dahurica, rhubarb, phellodendron, bletilla striata, angelica and liquorice in sesame oil for 6 days according to the parts by weight; meanwhile, the dragon's blood, the aloe and the catechu are ground into powder for standby.
Decocting oleum Sesami soaked with Chinese medicinal materials with slow fire until the medicine is brown, separating to obtain residue, adding powders of sanguis Draxonis, Aloe and Catechu, heating with slow fire for 25 min after it emerges from the oil surface, filtering to remove residue, adding Cera flava and Borneolum Syntheticum in parts by weight, filtering with double-layer gauze, and making into ointment.
Test example 1 evaluation of therapeutic effects on bedsore
296 decubitus patients were treated with the ointment of example 2, of which 187 men and 109 women had an age distribution of 39-82 years.
The treatment method comprises the following steps: the wound surface was cleaned with 0.9% sodium chloride injection and then coated with the ointment of example 2, changing the dressing once a day.
The criteria for efficacy assessment are as follows:
and (3) healing: the wound surface disappears and the surface epithelium is covered.
Improvement: the wound surface area shrinks and the granulation tissue grows well.
And (4) invalidation: more local skin exudation, unchanged and enlarged bedsore wound surface, increased exudation and ulceration area, local malodor and ulceration of water bubbles.
The evaluation results of the therapeutic effect of bedsore are shown in table 1.
Test example 2 evaluation of the efficacy of varicose vein with ulcer of lower limbs
118 patients with varicose veins and ulcer of lower limbs were treated with the ointment of example 2, wherein 42 men and 76 women were aged 42-76 years and had ulcer area of 25cm or less2。
The treatment method comprises the following steps: firstly, debriding pus and rotten tissues, then uniformly coating the ointment of the embodiment 2 on ulcer surfaces with the thickness of about 2-4mm, and covering a medical cotton pad; the dressing change is carried out once a day.
The evaluation standard of the curative effect refers to the diagnosis of the disease symptoms of the traditional Chinese medicine and the standard of the curative effect (Nanjing Daizhu publishing company); the evaluation results of the curative effect of varicose vein with ulcer of lower limb are shown in table 1.
Test example 3 evaluation of diabetic foot therapeutic efficacy
114 diabetic foot patients were treated with the ointment of example 2, 61 men and 53 women, with an age distribution of 46-78 years and a course of 1 month-5 years.
The treatment method comprises the following steps: the wound surface was washed with physiological saline, then externally coated with the ointment of example 2 to a thickness of about 5mm, covered with an external dressing, and changed once every 1 to 2 days depending on the exudation of the wound surface.
The criteria for efficacy assessment are as follows:
and (3) healing: the ulcer surface epidermis is completely healed without functional disorder.
Improvement: the ulcer surface is reduced by more than or equal to 40 percent, the red swelling is subsided, the wound surface is clean, and fresh tissues are generated.
And (4) invalidation: the ulcer surface is enlarged, the red swelling is not resolved or worsened, or secondary infection is caused, and secretion is increased.
The results of the diabetic foot treatment are shown in table 1.
Test example 4 evaluation of the effect of non-healing of postoperative incision
98 patients with non-healing postoperative incision were treated with the ointment of example 2, 54 men and 44 women, with an age distribution of 16-72 years.
The treatment method comprises the following steps: the skin around the wound surface was sterilized with 75% alcohol cotton balls, and the wound surface was washed clean with physiological saline cotton balls, and then the ointment of example 2 was applied externally, preferably with a thickness such that granulation tissue was not exposed, covered with gauze, and changed once in 1 to 2 days according to the case of the secretion of the pimple.
The criteria for efficacy assessment are as follows:
and (3) healing: the wound is completely healed or scars are formed, and the redness, swelling and pain disappear.
Improvement: the wound is reduced, the red and swollen range is partially removed, and the pain is relieved.
And (4) invalidation: the wound has no obvious improvement.
The evaluation results of the healing efficacy of the non-healing incision after operation are shown in table 1.
Test example 5 evaluation of burn and scald efficacy
65 burn and scald patients were treated with the ointment of example 2, of which 41 men and 24 women had an age distribution of 2-68 years.
The treatment method comprises the following steps: the wound was debrided and then externally applied with the ointment of example 2, and changed once a day.
The criteria for efficacy assessment are as follows:
and (3) healing: the wound surface is completely healed.
Improvement: the wound surface is reduced, but less than 50%.
And (4) invalidation: the wound surface is not obviously reduced.
The results of the burn and scald treatment are shown in table 1.
TABLE 1 evaluation of therapeutic effects
Typical cases are:
case one:
somebody song, man, 68 years old, Shandong chat people have descended. The cerebrovascular disease is bedridden for 2 years, the householders are not nursed properly, the sacral tail bedsore is caused, the size of the sacral tail bedsore is about 8cm by 7cm, the surface of the sacral tail bedsore is covered by black scabs, and the ulcer surface is deep and large on the sacral surface after the black scabs are removed, so that the odor is generated. The surrounding skin is dark in color. The drug of example 2 was used for changing the drug once a day for 30 days in 2017, 4 months and 39 days after drug administration, the granulation tissue of the wound surface at the tail of the sacrum grew flat, the epithelial tissue around the sacrum grew flat, and the wound surface shrunk. The wound surface healed after 19 days for 6 months (see fig. 1).
Case two:
somebody Guo, male, age 78, chat about east Asian. Cerebrovascular disease is bedridden for 5 years. Improper nursing causes a pressure sore on the left hip, and the wound surface with irregular size of about 20cm x 15cm is covered by dry scab on the surface. The drug of example 2 was used for treatment on 18/12/2017, the drug was changed once every two days, the dry scab was softened, the necrotic tissue was completely removed on 1/2018, and the granulation grew well after changing the drug once a day. The wound surface healed in 2 months and 8 days (see fig. 2).
Case three:
yue somebody, male, 76 years old. Chatting a tall and down man. Varicose veins of both lower limbs are 30 years old, skin pigmentation of both lower legs is more than 20 years old, and skin of the left lower leg is ulcerated for 2 years and is not healed. The local hospital carries out the high ligation and the denudation treatment of the double lower limbs great saphenous vein. The ulcer surface is still not healed after the dressing change treatment of the wound surface. The drug of example 2 was used for treatment from 11 months in 2015, the ulcer surface was gradually improved after changing once a day, and the fibrosis granulation was fresh after 2 weeks. After dressing change for 1 month, the ulcer surface is basically covered with granulation. The ulcer surface heals after 2 months of using the medicine (see figure 3).
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating skin ulceration is characterized by comprising the following raw materials in parts by weight: 10-15 parts of angelica dahurica, 12-18 parts of rhubarb, 12-18 parts of phellodendron, 28-32 parts of bletilla striata, 18-22 parts of angelica, 18-22 parts of liquorice, 18-22 parts of dragon's blood, 28-32 parts of aloe, 18-22 parts of catechu and 5-7 parts of borneol.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 12 parts of angelica dahurica, 15 parts of rhubarb, 15 parts of phellodendron, 30 parts of bletilla, 20 parts of angelica, 20 parts of liquorice, 20 parts of dragon's blood, 30 parts of aloe, 20 parts of catechu and 6 parts of borneol.
3. Use of a Chinese medicinal composition according to claim 1 or 2 in the manufacture of a medicament for the treatment of skin ulceration;
preferably, the skin ulcer comprises at least one of bedsore, burn, scald, varicose vein of lower limb with ulcer, diabetic foot, non-healing after incision operation, rhagadia manus et pedis, eczema and dermatitis.
4. An ointment for treating skin ulceration, prepared by the traditional Chinese medicine composition of claim 1 or 2.
5. The ointment of claim 4, wherein the raw materials comprise a matrix and the Chinese medicinal composition of claim 1 or 2, wherein the matrix comprises 800 parts of vegetable oil and 160 parts of lipid;
preferably, the matrix comprises 1000 parts of vegetable oil and 150 parts of lipid.
6. The ointment of claim 5, wherein the vegetable oil is at least one selected from the group consisting of sesame oil, soybean oil, peanut oil and rape oil, preferably sesame oil;
preferably, the lipid is selected from at least one of beeswax, lanolin, insect wax and whale vinegar, more preferably beeswax.
7. A method for producing the paste according to any one of claims 4 to 6, comprising:
grinding sanguis Draxonis, Aloe and Catechu into powder;
soaking angelica dahurica, rhubarb, phellodendron, bletilla striata, angelica and liquorice in vegetable oil according to parts by weight, decocting with slow fire, and separating dregs of a decoction;
adding the ground dragon's blood, aloe and catechu into the vegetable oil with dregs separated according to the weight portion, heating with small fire, separating dregs, adding beeswax and borneol according to the weight portion, filtering and forming ointment.
8. The method of claim 7, wherein the soaking time is controlled to be 3 to 7 days, preferably 5 days.
9. The method of claim 7, wherein the heating time by the small fire is controlled to be 15 to 25 minutes, preferably 20 minutes.
10. The method of claim 7, wherein the filtering is performed using a double layer of gauze.
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| CN114344379A (en) * | 2022-01-19 | 2022-04-15 | 陈林 | Herbal medicine formula for treating general ulceration and application thereof |
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| 官世芳: "加味神应当归膏治疗烧烫伤 269 例疗效观察", 《天津中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114344379A (en) * | 2022-01-19 | 2022-04-15 | 陈林 | Herbal medicine formula for treating general ulceration and application thereof |
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Application publication date: 20200818 |