CN103948807A - Formula and preparation method of paste capable of removing slough and promoting tissue regeneration - Google Patents
Formula and preparation method of paste capable of removing slough and promoting tissue regeneration Download PDFInfo
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Abstract
The invention relates to medical technology and in particular relates to a formula and preparation method of paste capable of removing slough and promoting tissue regeneration for treating skin ulcer. The formula of the paste capable of removing slough and promoting tissue regeneration is characterized by comprising the following components in parts by weight: 50-70 parts of Chinese angelica, 15-20 parts of angelica root, 8-12 parts of bletilla, 8-10 parts of amber, 50-70 parts of beewax, 5-7 parts of lithospermum, 8-10 parts of liquorice, 450-500 parts of sesame oil and 10-12 parts of dragon's blood. The paste capable of removing slough and promoting tissue regeneration is a pure traditional Chinese medicine preparation formed by combining the modern science and technology on the basis of inheriting excellent achievements of the formers, has the effects of removing slough, drawing out pus, pushing toxicity and promoting tissue regeneration, has the advantages of definite curative effect, low cost and no obvious toxic and side effect and is applicable to a patient with canker caused by skin ulceration, especially during treatment of chronic ulceration such as bedsore and diabetes gangrene. The medicine can obviously promote ulcer healing and significantly improve cure rate.
Description
Technical field
The present invention relates to Chinese medicine technology, be specially a kind of putrefaction-removing granulation-promoting paste formulation for the treatment of skin ulcer and preparation method thereof.
Background technology
Skin ulcer is an ancient problem.In recent years, along with the raising of cerebrovascular and onset diabetes rate, the sickness rate of the chronic skin ulcer such as decubital ulcer, diabetic gangrene significantly rises.Wherein diabetic gangrene's prevalence is 15% of diabetics sum.
But, there is no at present a kind of effective Chinese medicine of fine treatment skin ulcer.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine of effective treatment skin ulcer.
The present invention adopts following technical scheme to realize:
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion:
Radix Angelicae Sinensis 50-70 part, Radix Angelicae Dahuricae 15-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-12 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Glycyrrhizae 8-10 part, Sanguis Draxonis 10-12 part, succinum 8-10 part, Cera Flava 50-70 part, Oleum Sesami 450-500 part.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 60～72 hours, be then heated to 200～220 ℃, insulation 20～25min, filters and obtains filtrate I after cooling;
(4), filtrate I is heated to 200～220 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
Using method: external; Get appropriate mastic coating affected part, one day or the next day 1 time.
Radix Angelicae Sinensis: warm in nature, acrid in the mouth, sweet, returns liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, the effect of protection kidney.Be used for the treatment of blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatism paralysis, traumatic injury, the diseases such as ulcer sores.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth.Attach to the lung and stomach meridians.Have expelling pathogenic wind from the body surface, skin infection swells and ache, removing dampness leukorrhagia stopping effect.To skin infection from the beginning of dissipating, can evacuation of pus after bursting.
The Pseudobulbus Bletillae (Rhizoma Bletillae): cold nature, bitter in the mouth, sweet, puckery.Return lung, liver, stomach warp.Have astringing to arrest bleeding, detumescence and promoting granulation effect, with controlling the diseases such as carbuncle ulcer, burn and scald.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth.GUIXIN, Liver Channel.There is removing toxic substances rash, the effect of removing pathogenic heat from blood and toxic substance from the body.With controlling the diseases such as furuncle carbuncle, eczema, dermatitis, pudendal pruritus.
Sanguis Draxonis: property is sweet, salty, taste is flat.GUIXIN, liver, spleen channel.There is promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation, the effect of sore.With controlling traumatic injury, congestion swells and ache, traumatic hemorrhage, the diseases such as ulcer being unable to heal.
Radix Glycyrrhizae: property is flat, sweet in the mouth.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, the effect of cushion toxicity and strong and coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, gastral cavity abdomen, the anxious pain of extremity contraction, the diseases such as carbuncle sore tumefacting virus.
Succinum: property is flat, sweet in the mouth.GUIXIN, liver, urinary bladder channel.There is tranquillizing and allaying excitement, blood circulation promoting and blood stasis dispelling, the effect of inducing diuresis for treating stranguria syndrome.With controlling the diseases such as stagnation of QI and blood.
Cera Flava: be the materials of four pairs of wax gland secretions below worker bee abdominal part, its main component has: acids, free fatty, free alkyl alcohol and carbohydrate; In addition, also have carotenoid, vitamin A, aromatic substance etc.Function cures mainly: astringent therapy, sore, granulation promoting, pain relieving, conditioning.For ulcer being unable to heal, ecthyma is rotten to the corn, wound, burn outward.
Oleum Sesami: refer to Oleum sesami, Chinese medicine is thought: this product nature and flavor are sweet, cool, has the effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.According to recording on < < Compendium of Materia Medica > >: " have moisturize, the merit of removing toxic substances, pain relieving, detumescence." clinically also with Oleum Sesami, decoct plaster, there is granulation promoting meat, an effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.
Putrefaction-removing granulation-promoting paste of the present invention is to inherit on the basis of the outstanding achievement of forefathers, application Traditional Chinese medical theory, the pure Chinese medicinal preparation forming after constantly groping, promoting blood circulation and stopping pain, putrefaction-removing granulation-promoting, the whole QI-blood circulation function of adjusting human body of take is object, has that putrefaction removing is drawn out the pus, the effect of promoting pus discharge and tissue regeneration strengthening.In mastic, Radix Angelicae Sinensis, Radix Arnebiae (Radix Lithospermi), succinum have promoting blood circulation and cooling blood, and eliminating stasis to stop pain promotes granulation growth, epithelial repair effect; Sanguis Draxonis, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae have sore hemostasis, detumescence and promoting granulation effect; In addition Radix Glycyrrhizae hemostasis by invigorating QI, the property of medicine that is in harmonious proportion.Applicant is through clinical practice experience for many years, constantly sum up perfect, preferred above-mentioned Chinese medicinal components, realize the reasonable compatibility between plurality of Chinese component, reach complementary effect, thereby on clinical treatment skin ulcer, possess invigorate blood circulation, the multi-effect such as pain relieving, putrefaction removing, granulation promoting, reach the object to skin surgery skin infection repairing and treating.
This Chinese medicine preparation determined curative effect, cheap, without obvious toxic and side effects, be applicable to the Peptic Ulcers patient who causes because of skin ulceration, particularly, in the treatment of the chronic ulcers such as decubital ulcer, diabetic gangrene, this medicine can obviously promote to significantly improve cure rate by ulcer healing.In recent years, Shanxi Province Science and Technology Department organizes " the clinical and experimentation of putrefaction-removing granulation-promoting paste treatment skin ulcer " project that relevant expert completes No.1 Hospital, Shanxi Medical Univ to carry out assessment of result, unanimously think, use this putrefaction-removing granulation-promoting paste to treat the clinical observation of 132 routine skin ulcer inpatients, total effective rate reaches 93.47%, significantly be better than contrasting medicine Shengji Yuhong Gao, and without obvious toxic-side effects.
model case:
King so-and-so, female, 35 years old, Yuncheng, Shanxi people, was in hospital because traffic accident wound causes skin ulcer for 2002, skin ulcer face scope is larger, external putrefaction-removing granulation-promoting paste of the present invention is after one week, ulcer skin starts to be clearly better, and adheres to that medication is after two weeks after leaving hospital, the recovery from illness of skin ulcer face.
Zhang, man, 57 years old, Taiyuan, Shanxi people, suffered from diabetes for many years, within 2005, because of skin ulcer, was in hospital, and skin ulcer face reaches flesh layer deeply, and external putrefaction-removing granulation-promoting paste of the present invention is after two weeks, and ulcer skin starts to be clearly better, and adheres to that medication is after three weeks after leaving hospital, the recovery from illness of skin ulcer face.
Zhao so-and-so, female, 28 years old, Linfen, Shanxi people, 2006 because of after careless burn, occurs skin ulcer, and local skin reaches deepⅱ°burn, and external putrefaction-removing granulation-promoting paste of the present invention is after three days, ulcer skin starts to be clearly better, and adheres to that medication is after two weeks after leaving hospital, the recovery from illness of skin ulcer face.
Permitted certain, man, 72 years old, Taiyuan, Shanxi people, because of handicapped for a long time, bed for many years, was in hospital because pressure ulcer appears in skin in 2009; diseased region is nearer apart from anus; local skin concurrent infection, and external putrefaction-removing granulation-promoting paste of the present invention is after six weeks, and ulcer skin starts to be clearly better; after leaving hospital, adhere to that medication is after eight weeks, the recovery from illness of skin ulcer face.
The present invention improves traditional external prescription drugs and processing technique, reduces drug toxicity, and value for clinical application is large.And the required medical material cost of this medicine is low, preparation method is simple, the material benefit of finished medicines price, thus alleviated extensive patients and family members' burden, be the more economic benefit of social creativity.
The specific embodiment
Below specific embodiments of the invention are elaborated.
embodiment 1
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion: every part of 1g,
55 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Angelicae Dahuricae, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of succinums, 70 parts, Cera Flava, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts, Radix Glycyrrhizae, 480 parts, Oleum Sesami, 11 parts of Sanguis Draxonis.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 72 hours, be then heated to 210 ℃, after insulation 20min, color is coke yellow, after cooling, filters and obtains filtrate I;
(4), filtrate I is heated to 220 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
embodiment 2
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion: every part of 5g,
60 parts of Radix Angelicae Sinensis, 18 parts of the Radixs Angelicae Dahuricae, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 8 parts of succinums, 65 parts, Cera Flava, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts, Radix Glycyrrhizae, 500 parts, Oleum Sesami, 12 parts of Sanguis Draxonis.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 65 hours, be then heated to 220 ℃, after insulation 22min, color is coke yellow, after cooling, filters and obtains filtrate I;
(4), filtrate I is heated to 215 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
embodiment 3
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion:
70 parts of Radix Angelicae Sinensis, 15 parts of the Radixs Angelicae Dahuricae, 12 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 9 parts of succinums, 60 parts, Cera Flava, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 9 parts, Radix Glycyrrhizae, 460 parts, Oleum Sesami, 10 parts of Sanguis Draxonis.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 60 hours, be then heated to 215 ℃, after insulation 23min, color is coke yellow, after cooling, filters and obtains filtrate I;
(4), filtrate I is heated to 205 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
embodiment 4
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion:
50 parts of Radix Angelicae Sinensis, 17 parts of the Radixs Angelicae Dahuricae, 9 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 8 parts of succinums, 55 parts, Cera Flava, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts, Radix Glycyrrhizae, 450 parts, Oleum Sesami, 10 parts of Sanguis Draxonis.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 70 hours, be then heated to 200 ℃, after insulation 25min, color is coke yellow, after cooling, filters and obtains filtrate I;
(4), filtrate I is heated to 210 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
embodiment 5
A putrefaction-removing granulation-promoting paste formulation, consists of the composition of following weight portion:
65 parts of Radix Angelicae Sinensis, 16 parts of the Radixs Angelicae Dahuricae, 11 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of succinums, 50 parts, Cera Flava, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 9 parts, Radix Glycyrrhizae, 470 parts, Oleum Sesami, 11 parts of Sanguis Draxonis.
A preparation method for putrefaction-removing granulation-promoting paste, comprises the steps:
(1), take the various compositions in above-mentioned formula;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 68 hours, be then heated to 220 ℃, after insulation 23min, color is coke yellow, after cooling, filters and obtains filtrate I;
(4), filtrate I is heated to 200 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
Claims (2)
1. a putrefaction-removing granulation-promoting paste formulation, is characterized in that: the composition by following weight portion forms:
Radix Angelicae Sinensis 50-70 part, Radix Angelicae Dahuricae 15-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-12 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Glycyrrhizae 8-10 part, Sanguis Draxonis 10-12 part, succinum 8-10 part, Cera Flava 50-70 part, Oleum Sesami 450-500 part.
2. a preparation method for putrefaction-removing granulation-promoting paste, is characterized in that: comprise the steps:
(1), take the various compositions in formula described in claim 1;
(2), succinum is pulverized to last to make raw material I standby;
(3), Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are together placed in Oleum Sesami pot and are soaked 60～72 hours, be then heated to 200～220 ℃, insulation 20～25min, filters and obtains filtrate I after cooling;
(4), filtrate I is heated to 200～220 ℃, add Sanguis Draxonisization to the greatest extent, after cooling, filter and obtain filtrate II;
(5) raw material I and Cera Flava are joined in filtrate II simultaneously, be heated to Cera Flava fusing, stir, after cooling, filter and obtain filtrate III;
(6), filtrate III is stirred after condensation and obtain putrefaction-removing granulation-promoting paste.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547590A (en) * | 2015-01-25 | 2015-04-29 | 秦佑胜 | Medicine composition for treating diabetic foot |
| CN104983975A (en) * | 2015-06-10 | 2015-10-21 | 武文峰 | Paste removing slough and promoting tissue regeneration |
| CN109350711A (en) * | 2018-04-08 | 2019-02-19 | 刘勇跃 | A kind of combined traditional Chinese medicine preparation that treating diabetes and preparation method |
| CN109954063A (en) * | 2019-05-13 | 2019-07-02 | 庄元镜 | The ointment and preparation method thereof for treating diabetes |
| CN111184843A (en) * | 2020-02-19 | 2020-05-22 | 华东医院 | Traditional Chinese medicine composition for promoting diabetic ulcer wound repair and preparation method thereof |
| CN111544523A (en) * | 2020-06-03 | 2020-08-18 | 金镇� | Traditional Chinese medicine composition for treating skin ulceration and application thereof |
| CN111617189A (en) * | 2020-07-06 | 2020-09-04 | 河南省人民医院 | Traditional Chinese medicine composition for treating dry skin chap |
| CN115364150A (en) * | 2022-08-26 | 2022-11-22 | 江阴东方生物科技有限公司 | Liquid plaster and preparation method thereof |
| CN116889585A (en) * | 2023-08-30 | 2023-10-17 | 高敏 | Radix lithospermi sore healing oil, preparation method and application thereof |
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| CN1055297A (en) * | 1991-03-28 | 1991-10-16 | 许聿祥 | A kind of autofrettage of skin-moistening burn and scald medicine |
| CN1210000A (en) * | 1997-09-03 | 1999-03-10 | 田明行 | Ointment for wounds and sores and preparation thereof |
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Patent Citations (2)
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| CN1055297A (en) * | 1991-03-28 | 1991-10-16 | 许聿祥 | A kind of autofrettage of skin-moistening burn and scald medicine |
| CN1210000A (en) * | 1997-09-03 | 1999-03-10 | 田明行 | Ointment for wounds and sores and preparation thereof |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547590A (en) * | 2015-01-25 | 2015-04-29 | 秦佑胜 | Medicine composition for treating diabetic foot |
| CN104983975A (en) * | 2015-06-10 | 2015-10-21 | 武文峰 | Paste removing slough and promoting tissue regeneration |
| CN109350711A (en) * | 2018-04-08 | 2019-02-19 | 刘勇跃 | A kind of combined traditional Chinese medicine preparation that treating diabetes and preparation method |
| CN109954063A (en) * | 2019-05-13 | 2019-07-02 | 庄元镜 | The ointment and preparation method thereof for treating diabetes |
| CN111184843A (en) * | 2020-02-19 | 2020-05-22 | 华东医院 | Traditional Chinese medicine composition for promoting diabetic ulcer wound repair and preparation method thereof |
| CN111544523A (en) * | 2020-06-03 | 2020-08-18 | 金镇� | Traditional Chinese medicine composition for treating skin ulceration and application thereof |
| CN111617189A (en) * | 2020-07-06 | 2020-09-04 | 河南省人民医院 | Traditional Chinese medicine composition for treating dry skin chap |
| CN115364150A (en) * | 2022-08-26 | 2022-11-22 | 江阴东方生物科技有限公司 | Liquid plaster and preparation method thereof |
| CN116889585A (en) * | 2023-08-30 | 2023-10-17 | 高敏 | Radix lithospermi sore healing oil, preparation method and application thereof |
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