CN103230493B - Traditional Chinese medicine composition for treating unhealed wound - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating an unhealed wound. The medicine comprises raw materials by weight percent as follows: 30g of dragon's blood, 10g of frankincense, 15g of pearl essence, 10g of flowers carthami, 15g of radix angelicae, 15g of liquorice, 5g of honeysuckle, 10g of Astragalus mongholicus, 20g of the root of red-rooted salvia, 5g of myrrh, 5g of leech, 15g of rheum officinale and 15g of golden cypress. The medicine provided by the invention has the beneficial effects that the medicine has the effects of abundant medicinal herbs resource, low cost, simple preparation method, convenience in use and high curative effect to treat unhealed wound, is free from allergy, toxic reaction and side effects, and has the effects of diminishing inflammation and detoxifying, removing corrosion and relieving pain, removing stasis and promoting tissue regeneration and the like. The raw materials have synergistic effect and are effective to unhealed wound caused by various reasons.

Description

A kind of Chinese medicine composition for the treatment of wound and not healing

Technical field

The present invention relates to the external application Chinese medicine in a kind of technical field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of wound and not healing.

Background technology

Wound is not healed, and is more common in various operation, chronic ulcer, damage repeated infection, burn and scald injure sinus tract etc.Visible wound surface is not fresh clinically, dimly around wound redly to harden; Or the necrosis of local epidermal tissue is dry and hard, subsides in wound central authorities, discontinuity pus or sepage are flowed out; Or local organization edema; Or repeated infection forms sinus tract.In modern traumatherapy, Therapeutic Method and medicine varied, but do not reach gratifying degree yet, still have an a lot of difficult problem not yet to solve.As 1, wound healing is slow: more wound ubiquity is long for the course for the treatment of, and slow curative effect, the problems such as inflammation recurrent exerbation, cause skin obstinate even to fester.And ulcer surface can be made to be difficult to control, or wound surface is made to be difficult to healing because granulation tissue is formed slowly.2, wound can not heal: doctor trained in Western medicine adopts antibiotic to add dressing change, and the traditional Chinese medical science adopts Traditional Chinese medicine external preparation, and two kinds of methods all can not make wound normal healing, can only adopt the method wound closures such as skin-grafting.3, traumatic infection can not control: more wound granulation tissue is not stale, and wound surface has secretions or pus tongue, and antibacterial causes infection in wound surface breeding, forms pyemia.We are through scientific appraisal, screening, test, have invented the Chinese medicine composition being used for the treatment of various wound and not healing.

Summary of the invention

The present invention, in order to overcome the deficiencies in the prior art, provides a kind of cost low, easy to use, more curative effect is high for treatment wound, has that removing mass is drawn out pus by applying a plaster to the affected part, blood stasis removing pain relieving, putrefaction-removing granulation-promoting, effect of antiinflammatory, removing toxic substances of dispeling the wind, to the not effective medicine of wound that a variety of causes causes.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine composition for the treatment of wound and not healing, and it is characterized in that being made up of the raw material of Chinese medicine of following weight: Sanguis Draxonis 30g, Olibanum 10g, Margarita powder 15g, Flos Carthami 10g, Radix Angelicae Dahuricae 15g, Radix Glycyrrhizae 15g, Flos Lonicerae 5g, Radix Astragali 10g, Radix Salviae Miltiorrhizae 20g, Myrrha 5g, Hirudo 5g, Radix Et Rhizoma Rhei 15g, Cortex Phellodendri 15g.

Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, selected medicament composing prescription.In the present invention in drug composition: Sanguis Draxonis is sweet, salty, flat, enter the heart, liver, spleen channel; Promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation, sore; Control treating swelling and pain by traumatic injury, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.Olibanum is pungent, bitter, temperature; Enter the heart, liver, spleen channel; Have antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, vulnerary effect.Margarita powder: removing toxic substances and promoting granulation.The skin injury caused a variety of causes is as timely Margarita powder such as knife injury, scratch, scald, burn, eczema, chickenpoxs, and can stop blooding fast, close up fast, put on flesh fast, antiinflammatory is fast, and preventing from scar.Flos Carthami is warm in nature, acrid in the mouth, GUIXIN, Liver Channel; Its gas perfume row is loose, enters blood system and has promoting blood circulation to restore menstrual flow, effect of stasis-dispelling and pain-killing; Be mainly used in dysmenorrhea, amenorrhea, puerperal blood faints, the stagnant stomachache of the stasis of blood, obstruction of qi in the chest and cardialgia, accumulation of blood, traumatic injury congestive edema, arthralgia, paralysis due to windstroke, macular eruption being dark-purple.The Radix Angelicae Dahuricae is pungent, temperature; Attach to the lung and stomach meridians; Expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping; For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus; Modern pharmacological research proves that the Radix Angelicae Dahuricae also has the effect such as antiinflammatory, antipyretic-antalgic.Radix Glycyrrhizae property is put down, sweet in the mouth, has removing toxic substances, eliminates the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, carbuncle sore tumefacting virus, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; For carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease is generated heat; The medicinal efficacy of Flos Lonicerae: 1. antibacterial and antiviral: namely have obvious inhibitory action to staphylococcus aureus, Hemolytic streptococcus, dysentery, typhoid fever, meningococcus, Diplococcus pneumoniae, green pus and influenza virus etc.2. strengthen the function of immunity: lymphocyte transformation can be promoted, strengthen leukocytic phagocytic function.3. antiinflammatory, antipyretic: the release that can promote adrenocortical hormone, has obvious inhibitory action to inflammation.The Radix Astragali QI invigorating sun, benefit defends consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent, control carbuncle burst or burst do not hold back for a long time, there is enhancing immunologic function, enhancing body anoxia enduring and stress ability, promotion organism metabolism, antibacterial and antiviral effect; In nutritional solution, add the Radix Astragali of 0.5%, can make living cells showed increased, Growth of Cells is vigorous, the life that cell grows in vitro about a times.Radix Salviae Miltiorrhizae has and promotes the reparation of tissue and regeneration: 1. promote the reparation organized and regeneration: red sage formulation is removed soon to necrotic myocardium; Fibroblast differentiation, collagen fiber are formed more obvious; Granulation forms comparative maturity.Local congestion alleviates, blood circulation improves, and healing time shortens.2. suppress hyperplasia: have inhibitory action to the fibroblast of hyperplasia.3. contain cryptotanshinone, dihydrotanshinone in antibacterial red sage formulation, have inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Myrrha is pungent, bitter, flat; GUIXIN, liver, spleen channel; Dissipating blood stasis analgesic therapy, detumescence and promoting granulation; For obstruction of qi in the chest and cardialgia. gastralgia, dysmenorrhea amenorrhea. postpartum stagnation, addiction abdominal mass is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle skin infection.Hirudo salty in the mouth; Bitter; Property is put down; Poisonous; Return Liver Channel; Function removing blood stasis; To stimulate the menstrual flow eliminating mass.Cure mainly blood stasis amenorrhea; Lump in the abdomen mass in the abdomen; Traumatic injury.Radix Et Rhizoma Rhei nature and flavor: bitter, cold; Return stomach warp; Large intestine channel; Liver Channel; Spleen channel; Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cortex Phellodendri is bitter, cold; Return kidney, urinary bladder channel; Effect: heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.Drug component in the present composition, through dialectical compatibility, complements each other using, has synergism, play promoting blood circulation to remove blood stasis, evacuation of pus altogether, antiinflammatory, antipyretic-antalgic, hemostasia and promoting granulation, effect of sore, thus reaches the object that treatment wound do not heal.

The invention has the beneficial effects as follows that medicine source is enriched, cheap, compound method is simple, easy to use, and more curative effect is not high for treatment wound, without irritated, non-toxic reaction, has no side effect, and has the effects such as eliminating inflammation and expelling toxin, putrefaction removing pain relieving, expelling the stasis for the new, each medical instrument has synergism, and the wound caused a variety of causes is ineffective.

Detailed description of the invention

Embodiment 1: a kind of Chinese medicine composition for the treatment of wound and not healing, it is made up of the raw material of Chinese medicine of following weight: Sanguis Draxonis 30g, Olibanum 10g, Margarita powder 15g, Flos Carthami 10g, Radix Angelicae Dahuricae 15g, Radix Glycyrrhizae 15g, Flos Lonicerae 5g, Radix Astragali 10g, Radix Salviae Miltiorrhizae 20g, Myrrha 5g, Hirudo 5g, Radix Et Rhizoma Rhei 15g, Cortex Phellodendri 15g.

Get above-mentioned 13 taste Chinese herbal medicine gross weight 170 grams, at room temperature said herbal medicine is cut into slices or section, grind to the powder altogether, after autoclave sterilization, to load in Brown Glass Brown glass bottles and jars only or airtight for subsequent use in porcelain vase.Usage: wound surface routine disinfection, the shallow person of wound table, is directly spread on medicated powder on wound surface, covers with sterilization normal saline gauze; Wound is comparatively dark or have sinus tract person, removes pus and secretions in sinus tract with 3% hydrogen peroxide, is bonded at by medicated powder on sterilization normal saline gauze drain bar, is placed on bottom sinus tract.Points for attention: medicated powder will cover whole wound surface, thickness is even, and area is advisable slightly above surrounding normal skin.When secretions is more, change dressings every day 2 times; Secretions changes into and changing dressings every day 1 time after reducing; Without secretions, when wound surface is fresh, the next day, changes dressings 1 time.It within 10th, is 1 course for the treatment of.

Treat the Chinese medicine composition that wound is not healed, clinical efficacy is summed up:

One, case selection: the wound that a variety of causes causes more patient 195 example (anemia of pregnant woman's taboo) for a long time, the Chinese medicine composition (being set to treatment group totally 105 examples) all cases being divided into treatment wound not heal at random and Western medicine gentamycin group (are set to matched group totally 90 examples, change dressings with gentamycin normal saline gauze, method is identical with treatment group).Treatment group 105 example, wherein man 65 example, female 40 example; Age 26-72 year, average 48.5 years old; Out-patient 30 example, inpatient 75 example; The course of disease 20 days-5 months; Postoperative wound unhealed 15 example, chronic ulcer of lower extremity unhealed 34 example, limbs open fracture wound unhealed 31 example, burn and scald the wounded 25 example; Area 2cm × 3cm-17cm × 21cm.Matched group 90 example, wherein man 48 example, female 42 example; Age 25-70 year, average 51.2 years old; Out-patient 29 example, inpatient 61 example; The course of disease 20 days-6 months; Postoperative wound unhealed 17 example, chronic ulcer of lower extremity unhealed 30 example, limbs open fracture wound unhealed 19 example, burn and scald the wounded 24 example; Area 2.3cm × 3cm-14cm × 16cm.Two groups of case-datas, through statistical procedures there was no significant difference (P > 0.05), have comparability.

Two, diagnostic criteria: diagnostic criteria is with reference to the diagnostic criteria of newly organized " surgery ".

Three, Therapeutic Method: wound surface routine disinfection, the shallow person of wound table, is directly spread on medicated powder on wound surface, covers with sterilization normal saline gauze; Wound is comparatively dark or have sinus tract person, removes pus and secretions in sinus tract with 3% hydrogen peroxide, is bonded at by medicated powder on sterilization normal saline gauze drain bar, is placed on bottom sinus tract.Points for attention: medicated powder will cover whole wound surface, thickness is even, and area is advisable slightly above surrounding normal skin.When secretions is more, change dressings every day 2 times; Secretions changes into and changing dressings every day 1 time after reducing; Without secretions, when wound surface is fresh, the next day, changes dressings 1 time.It within 10th, is 1 course for the treatment of.

Four, Outcome measure: " Chinese medical disease Standardization of diagnosis and curative effect " that efficacy assessment standard is formulated with reference to Department of Medical Administration of State Administration of Traditional Chinese Medicine is formulated in conjunction with clinical practice.

Cure: wound healing, cicatrization.Effective: wound heals substantially, without pus and secretions, visible fresh granulation tissue.

Effective: wound reduces, secretions and transudate reduce.

Invalid: to contrast with before medication, wound changes not obvious.

Five, therapeutic outcome: use the present invention to treat 105 routine wounds more patient, carry out treatment effectiveness evaluation according to the standard of curative effect evaluation, cure 89 examples, account for 84.8%, effective 9 examples, account for 8.6%, and effective 5 examples, account for 4.8%, invalid 2 examples, account for 1.9%, and always effective 103 examples, account for 98.1%.Treatment by Chinese herbs group (totally 105 examples), Western medicine gentamycin is matched group (totally 90 examples).Western medicine gentamycin group cures 48 examples, accounts for 53.3%, and aobvious 19 examples of effect, account for 21.1%, and effective 12 examples, account for 13.3%, and invalid 11 examples, account for 12.2%, and always effective 71 examples, account for 78.9%.

Result shows: Chinese medicine composition of the present invention, at wound healing, reduces and infects, and shorten healing time aspect and be better than Western medicine gentamycin group, result of study also shows: have invigorating QI and blood, and Tuoli is thoroughly malicious, putrefaction removing of invigorating blood circulation, dehumidifying sore; Facilitation is had to the propagation of granulation tissue, can obvious accelerated wound healing.

Six, model case

Patient 1, female, 52 years old, because of wound outside left thigh 1 hour, is admitted to hospital on August 3rd, 2010.Check: the wound surface having 21cm × 15cm size outside left thigh, epidermis lacks, and subcutaneous fat exposes.Diagnosis: soft-tissue trauma outside left thigh.Give common changing dressings, change dressings every day 1 time, after treating 3 weeks, still have the wound surface of 12cm × 8cm size not heal, wound granulation is organized stale, and has purulent secretion.Now wound surface is after routine disinfection, uses the present invention instead and is directly spread on wound surface, covers, change dressings every day 2 times with sterilization normal saline gauze.After 4 days, wound surface is without pus, and granulation tissue is fresh.Change into and changing dressings every day 1 time, after 12 days, wound surface heals completely.

Patient 2, man, 38 years old, because pair upper limb was by electric burn 1 hour, are admitted to hospital on October 25th, 2009.Procuratorial work: two upper limb wound surface exfoliation, substrate is ruddy, touches a tender spot obviously; Local woanded surface substrate is pale, and have leather sample to change, sepage is less, touches a tender spot not obvious.Diagnosis: burn dark II ° 8%, III ° 7%, totally 15%.Wound surface is after treating 3 weeks with silver sulfadiazine ointment, and the right hand still has the wound surface of 14cm × 12cm size not heal, and wound granulation is organized stale, and has purulent secretion.Now wound surface is after routine disinfection, uses medicine of the present invention instead and is directly spread on wound surface, covers, change dressings every day 2 times with sterilization normal saline gauze.After 5 days, wound surface is without pus, and granulation tissue is fresh.Change into and changing dressings every day 1 time, after 14 days, wound surface heals completely.

Patient 3, female, 76 years old, because suffering from sciatic bedsore May, are admitted to hospital on April 19th, 2010.Procuratorial work: buttocks has the decubital ulcer of 20cm × 12cm size, and wound surface reaches muscle layer deeply, wound surface is not fresh, has purulent secretion, dimly around wound redly to harden; The necrosis of local epidermal tissue is dry and hard, diagnosis: decubital ulcer III phase.Now wound surface is after routine disinfection, uses the present invention instead and is directly spread on wound surface, covers, change dressings every day 2 times with sterilization normal saline gauze.After 7 days, wound surface is without pus, and granulation tissue is fresh.Change into and changing dressings every day 1 time, after 18 days, wound surface heals completely.

Claims (1)

1. treat the Chinese medicine composition that wound is not healed, it is characterized in that being made up of the raw material of Chinese medicine of following weight: Sanguis Draxonis 30g, Olibanum 10g, Margarita powder 15g, Flos Carthami 10g, Radix Angelicae Dahuricae 15g, Radix Glycyrrhizae 15g, Flos Lonicerae 5g, Radix Astragali 10g, Radix Salviae Miltiorrhizae 20g, Myrrha 5g, Hirudo 5g, Radix Et Rhizoma Rhei 15g, Cortex Phellodendri 15g.