A kind of Chinese medicine composition of treating surgical wound
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of Chinese medicine composition of treating surgical wound.
Background technology
From ancient times to the present, skin trauma, damage all are the surgical clinical commonly encountered diseases, and for example burn and scald, various wound, skin ulcer, mucosa injury or the like all belong to surgical wound.Long, the painful big and accompanying infection easily of the common course of disease of the treatment of surgical wound.
In clinical practice, doctor trained in Western medicine normally adopts 2% hydrogen peroxide, normal saline, ethanol, mercurochrome, iodine tincture, gentian voiet etc. to clean a wound the back with sterile gauze or kpetrolatum gauze covering earlier.Though this method sterilization effect is good, can not stop blooding, can not promote new cell growth; And common people are difficult to stand the unbearable pain that stimulates wound when above-mentioned liquid medicine cleans, and people describe with the alcohol wash wound has as above " cruel torture ".Over nearly 10 years, " adhesive bandage " circulates extensively in market, is mainly used in little wound, seals fresh wound with the iodine tincture gauze, pastes envelope and in time can cicatrize a wound, if the amount of bleeding greatly then is difficult to prove effective.This method generally only is suitable for the less wound of wound surface, for the bigger wound of wound surface or the edge is irregular, can not be fully to wound poor effect then.Moreover on wound, directly cover gauze, changing dressings also can cause wound pain, hemorrhage.
The common Dressed medicine powder of Chinese traditional treatment, all there be the nostrum or the secret recipe of treatment daggers and swords wound in each school of martial arts circles in early days, but its most secret recipes are lost gradually.At present, the Chinese medicine compound that is used for wound has YUNNAN BAIYAO, pink powder, SHENGJINDAO POWDER etc.Being used for the hemostatic traumatic mainly is YUNNAN BAIYAO at present, and former being named as " cure-all " is that Qu Huanzhang succeeded in developing in 1902, apart from the present T&B.The effect of YUNNAN BAIYAO removing stasis to stop bleeding, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling is remarkable; But its antibacterial infection poor effect; Medicated powder bonding wound influences drain; Need clean wound when changing dressings, thereby can cause wound pain, hemorrhage, and the zest of medicine also can cause, and wound pain increases the weight of, the course of disease prolongs.
Summary of the invention
The object of the invention aims to provide a kind of removing stasis to stop bleeding, pain relieving granulation promoting, antibacterial anti-infective Chinese medicine composition, is used to restrain diseases such as wound, accelerating wound healing, promotion wound, surgical operation, the puerperal wound healing of married woman.
Particularly, the present invention's Chinese medicine composition of treating surgical wound is processed by the raw material of following weight parts:
Fructus Forsythiae 5-20 part, Sanguis Draxonis 10-25 part, Myrrha 8-20 part, Olibanum 8-20 part, Radix Angelicae Dahuricae 15-25 part, Radix Sanguisorbae 5-25 part, Radix Notoginseng 5-25 part, Ramulus et Folium Tupidanthi celyptrati 10-25 part, Borneolum Syntheticum 5-10 part, Moschus 0.1-0.5 part, Cera Flava 0-120 part, Oleum sesami 300-500 part.
The Chinese medicine composition of above-mentioned treatment surgical wound is preferably processed by the raw material of following weight parts;
15 parts of Fructus Forsythiaes, 15 parts of Sanguis Draxonis, 15 parts of Myrrhas, 15 parts of Olibanums, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Sanguisorbaes, 18 parts of Radix Notoginseng, 18 parts of Ramulus et Folium Tupidanthi celyptratis, 7 parts of Borneolum Syntheticums, 0.1 part in Moschus, 110 parts in Cera Flava, 400 parts of Oleum sesami.
According to Chinese medical theory, Fructus Forsythiae in the present invention's prescription: hardship is slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens has the title of " persons particularly liable to develop skin infection's panacea ".Control warm, erysipelas, macule, the carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction, clearing away heart-fire.The Fructus Forsythiae concentrated decotion has an antibacterial action external, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.
Sanguis Draxonis: salty in the mouth property is flat, has eliminating stasis to stop pain, and the effect of hemostasia and promoting granulation can be treated traumatic injury, internal injury pain due to blood stasis, diseases such as continuous bleeding due to traumatic injury.
Myrrha: treating blood disorders is invigorated blood circulation, eliminating stasis to stop pain, detumescence and promoting granulation, blood fat reducing.Be used for stagnation of blood stasis, traumatic injury, ulcer sore pain or of a specified duration bursting are not held back.Compendium of Material Medica: " the blood detumescence of loosing, analgesic therapy granulation promoting." cloud again: " Olibanum is invigorated blood circulation, and the Myrrha blood that looses all can pain relieving.
Olibanum: the treating blood disorders blood circulation promoting and blood stasis dispelling, pain relieving, the warm heart is used for stagnation of blood stasis, rheumatic arthralgia, traumatic injury, diseases such as ulcer sore pain.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises and looses; Have expelling pathogenic wind from the body surface, dispersing cold for relieving pain, it is sensible to dehumidify, the effect of detumescence and apocenosis; Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, the venom contained.Radix Angelicae Dahuricae decoct all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.
Radix Sanguisorbae: bitter, acid, puckery is slightly cold.Return liver, large intestine channel.Cooling blood for hemostasis, skin ulcer is held back in detoxifcation.The Radix Sanguisorbae decocting liquid all has inhibitory action in various degree to Bacillus typhi, meningococcus, shigella flexneri, bacterium sonnei, beta hemolytic streptococcus, staphylococcus aureus, Diplococcus pneumoniae, diphtheria corynebacterium, escherichia coli, bacillus subtilis, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera and Bacillus tuberculosis.
Radix Notoginseng: warm in nature, sweet in the mouth, little hardship.Hemostasis, dissipating blood stasis, detumescence, pain relieving.
Ramulus et Folium Tupidanthi celyptrati: hardship, temperature.Go into lung, kidney,liver,spleen four warps.Relaxing muscles and tendons and activating QI and blood in the collateral, the circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea; Be used for traumatic injury, fracture pain person, the arthralgia aggravated by cold of cold and damp stagnation, affection of exogenous wind-cold, heating fear of cold, head-body-pain.
Borneolum Syntheticum: arduous, cold.Go into the heart, lung meridian.The main stagnated fire of loosing can deep heat, controls infantile convulsion, expectorant fan, sore throat, and swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not kept, also can the granulation promoting pain relieving.
Moschus: suffering, temperature, GUIXIN, spleen channel.The refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow is the central nervous excitation agent, external can be eased pain, subsided a swelling pain relieving.
Cera Flava: sweet, tepor.Astringent therapy is held back skin ulcer, granulation promoting, pain relieving, conditioning.Be used for ulcer being unable to heal outward, ecthyma is rotten to the corn, wound, burn.
Oleum sesami: can stop fat to produce the harmful substance of infringement cell, remove vivotoxin, effectively prevent the appearance of various mottles such as cyasma, senile plaque, make skin represent healthy glow.
What of Cera Flava consumption Chinese medicine composition of the present invention can process multiple dosage forms such as oil preparation, Emulsion, unguentum according to.Also can process gel, oily yarn etc. as required and be suitable for treating the dosage form of using.
Be preferably unguentum.
The said medicine dosage form all can adopt the conventional method preparation of pharmaceutical preparation.
Another object of the present invention provides a kind of method for preparing of treating the Chinese medicine composition of surgical wound, and concrete technical scheme is following:
(1) takes by weighing each crude drug in proportion, and Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus slightly are ground into medicated powder.
(2) Fructus Forsythiae, Ramulus et Folium Tupidanthi celyptrati, the Radix Angelicae Dahuricae, Radix Sanguisorbae and Oleum sesami were soaked 48 hours with putting in the pot, slow fire is heated to 115 ℃-120 ℃, keeps 10-30 minute, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.
(3) with step 2) filtrating is heated to 130-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10-15 minute, filter.
(4) Cera Flava is added in the step 3) filtrating be stirred to thawing, natural cooling gets Chinese medicine composition unguentum of the present invention.
In the above-mentioned method for preparing, in (4) step, do not add Cera Flava and promptly can be made into oil preparation; When the Cera Flava addition more after a little while, be Emulsion.
Though the indivedual single medicinal materials in the prescription of the present invention have the effect of treatment surgical wound, all are not enough to have good clinical therapeutic efficacy.The inventor is on the basis of secret prescription handed down in the family from generation to generation, and the screening prescription test through long-term, a large amount of obtains Chinese medicine composition of the present invention.Chinese medicine composition of the present invention is combined, and has good synergism.All herbal medicine couplings has all produced one-plus-one greater than two beyond thought technique effect in the Chinese medicine composition of the present invention, and for example removing stasis to stop bleeding, granulation promoting pain relieving, antibacterial anti-infective effect are much larger than the single medicine.And for example other all herbal medicines and Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Sanguisorbae three work in coordination with each other in the present invention, and the antibacterial anti-infective effect of Chinese medicine composition of the present invention is strengthened greatly.
The major advantage of Chinese medicine composition of the present invention is following:
1, bactericidal action is strong, and the wound mouth is not had stimulation.
2, granulation promoting relieving pain can promote corium to regenerate, and wound healing is fast.
3, wound healing is effective, has significantly reduced the generation of pigmentation and cicatrix.
4, flavour of a drug are few, and the property of medicine is flat, and medicine material is cheap and easy to get.
5, safe and reliable, have no side effect.
The specific embodiment:
Below description through the specific embodiment the present invention is described further; But this is not to be limitation of the present invention; Those skilled in the art are according to basic thought of the present invention; Can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within scope of the present invention.
Embodiment 1: take by weighing Sanguis Draxonis 15g, Olibanum 15g, Myrrha 15g, Radix Notoginseng 18g, Borneolum Syntheticum 7g, Moschus 0.1g, slightly be ground into medicated powder.With Fructus Forsythiae 15g, Ramulus et Folium Tupidanthi celyptrati 18g, Radix Angelicae Dahuricae 20g, Radix Sanguisorbae 10g and Oleum sesami 400g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 15 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10 minutes, filters.With being stirred to thawing in the Cera Flava 110g adding filtrating, natural cooling gets Chinese medicine composition unguentum of the present invention.
Embodiment 2: take by weighing Sanguis Draxonis 10g, Olibanum 8g, Myrrha 8g, Radix Notoginseng 5g, Borneolum Syntheticum 5g, Moschus 0.1g, slightly be ground into medicated powder.With Fructus Forsythiae 5g, Ramulus et Folium Tupidanthi celyptrati 10g, Radix Angelicae Dahuricae 15g, Radix Sanguisorbae 5g and Oleum sesami 300g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 10 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10 minutes, filters.With being stirred to thawing in the Cera Flava 80g adding filtrating, natural cooling gets Chinese medicine composition unguentum of the present invention.
Embodiment 3: take by weighing Sanguis Draxonis 25g, Olibanum 20g, Myrrha 20g, Radix Notoginseng 25g, Borneolum Syntheticum 10g, Moschus 0.5g, slightly be ground into medicated powder.With Fructus Forsythiae 20g, Ramulus et Folium Tupidanthi celyptrati 25g, Radix Angelicae Dahuricae 25g, Radix Sanguisorbae 25g and Oleum sesami 500g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 30 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 15 minutes, filters.With being stirred to thawing in the Cera Flava 100g adding filtrating, natural cooling gets Chinese medicine composition unguentum of the present invention.
Embodiment 4: take by weighing Sanguis Draxonis 18g, Olibanum 20g, Myrrha 18g, Radix Notoginseng 16g, Borneolum Syntheticum 9g, Moschus 0.2g, slightly be ground into medicated powder.With Fructus Forsythiae 15g, Ramulus et Folium Tupidanthi celyptrati 20g, Radix Angelicae Dahuricae 18g, Radix Sanguisorbae 18g and Oleum sesami 400g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 15 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10 minutes, filters.With being stirred to thawing in the Cera Flava 90g adding filtrating, natural cooling gets Chinese medicine composition unguentum of the present invention.
Embodiment 5: take by weighing Sanguis Draxonis 15g, Olibanum 15g, Myrrha 15g, Radix Notoginseng 18g, Borneolum Syntheticum 7g, Moschus 0.1g, slightly be ground into medicated powder.With Fructus Forsythiae 15g, Ramulus et Folium Tupidanthi celyptrati 18g, Radix Angelicae Dahuricae 20g, Radix Sanguisorbae 10g and Oleum sesami 400g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 15 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10 minutes, filters.With being stirred to thawing in the Cera Flava 40g adding filtrating, natural cooling gets Chinese medicine composition Emulsion of the present invention.
Embodiment 6: take by weighing Sanguis Draxonis 15g, Olibanum 15g, Myrrha 15g, Radix Notoginseng 18g, Borneolum Syntheticum 7g, Moschus 0.1g, slightly be ground into medicated powder.With Fructus Forsythiae 15g, Ramulus et Folium Tupidanthi celyptrati 18g, Radix Angelicae Dahuricae 20g, Radix Sanguisorbae 10g and Oleum sesami 400g with put soak 48 hours in the pot after, slow fire is heated to 115 ℃-120 ℃, keeps 15 minutes, friedly becomes coke yellow to the Radix Angelicae Dahuricae, filters the filtering medicinal residues.Filtrating is heated to 130 ℃-140 ℃, adds Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Borneolum Syntheticum, Moschus medicated powder, stirs, and keeps 10 minutes, filters, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Pharmacodynamic experiment and clinical case
One, medicine major function of the present invention and therapeutic domain
1, major function: treatment wound and wound healing, particularly suitable is with the treatment of fresh wound.
2, therapeutic domain: wound and wound healing.
3, usage and consumption: directly medicine-feeding, clean with normal saline in case of necessity, after conventional diagnosis and treatment, add medicine to.Last dose needs whole flap coverages, and thick with 1mm is good.Sepage was changed dressings once in one day for a long time, and sepage was changed dressings once in two days after a little while.
Two, the clinical observation of medicine of the present invention
1, physical data
Accept out-patient's 200 examples for medical treatment, wherein the age minimum is 14 years old, maximum 74 years old; At random the patient is divided into two groups, 160 examples are organized in treatment, give Drug therapy of the present invention, matched group 40 examples, and giving oneself has the method treatment; Control two groups of patients aspect mean age, the state of an illness, in a basic balance, have comparability.
2, diagnostic criteria
All case is that diagnosis is confirmed in diagnostic criteria by the wound clinical manifestation all.
3, Therapeutic Method
Under the voluntary prerequisite of patient, at random patient is divided into 2 groups, 160 examples are organized in treatment, application medicine of the present invention.Matched group 40 examples use oneself that the treatment of doctor trained in Western medicine method is arranged.
4, efficacy assessment standard (being as the criterion) with clinical symptom disappearance
Produce effects: wound heals fully.
Difference (invalid): various symptoms do not have the changer.
5, result and analysis (seeing table 1)
Table 1 liang group curative effect relatively
Group |
The example number |
Produce effects |
Difference |
Effective percentage (%) |
The treatment group |
160 |
160 |
0 |
100 |
Matched group |
40 |
27 |
13 |
67.5 |
Can find out that from table 1 treatment group curative effect obviously is superior to matched group, its total effective rate, cure rate are all apparently higher than matched group.
Three, clinical case(selecting some in the treatment group arbitrarily)
1, Wu, the man, 68 years old, in March, 2011 went to a doctor in here, and because of appendicitis is treated surgically at certain county hospital, the edge of a knife can not heal patient's readme in 20 days before 20 days, gave ointment treatment of the present invention then, healed after two days and took out stitches.
2, tall certain, the woman, 40 years old, diabetic history is arranged, in March, 2011 goes to a doctor in here, left hand palm knife injury, 8 pins are sewed up in the back of seeing and treating patients, application ointment treatment of the present invention, hemostasis and pain-relieving after the drug of topical application, healing is taken out stitches after two days.
3, Zhao, the man, 17 years old, in June, 2011 went to a doctor in here, left lower limb knife injury, application ointment of the present invention was treated after 13 pins were sewed up in the back of seeing and treating patients, hemostasis and pain-relieving after the drug of topical application, wound healing after two days, cicatrix disappears basically after 15 days.
4, Liu, the woman, 33 years old, April calendar year 2001 went to a doctor in here, is scalded by oil during work, scalded the degree of depth and reached 2 degree, and about 2 * 6 centimetres of area is smeared ointment treatment of the present invention, hemostasis and pain-relieving after the drug of topical application, after 12 days, wound heals fully, does not stay cicatrix.Prove that ointment of the present invention is effective to the treatment of burn.
5, by force certain, the woman, 28 years old, in December, 2011 came here to go to a doctor; Careless traumatic injury face causes facial extensive wound in the time of by bike, after simple the cleaning; Sew up two pins, smear ointment treatment of the present invention, after 3 days; Wound heals fully, obviously locates to continue application ointment of the present invention at scar, and cicatrix disappears after 12 days.
6, Liu, the man, 35 years old, in December, 2011 was drawn into hospital because of traffic accident; The multiple open injury of upper limb ancon, after giving debridement, sterilization, stitching, wrapping etc. and handling, partial smearing ointment treatment of the present invention; The next day, change dressings once, and wound healing after 7 days is taken out stitches and left hospital.
7, Lee, the man, 41 years old, in January, 2012 went to a doctor in here, and shank is extensively scalded during work; Area is 6 * 12 centimetres, blister occurs, and the traumatic infection pain is acute, smears ointment treatment of the present invention; Add medicine to after 15 minutes, pain disappears, and the next day changes dressings once, wound healing after 14 days.
Process is to the not effect analysis of wound of the same race of traditional Chinese medicine composition for treating of the present invention, and visible its effective percentage is high, and wound healing is fast, secondary infection can not take place during the treatment, and cicatrix and pigmentation are seldom left in the affected part.For sharp weapon incised wounds, the treatment of dampening, the therapeutic effect of can reach rapid hemostasis, pain relieving, protecting from infection can make wound healing.For the treatment of post-operative wound disunion, can reach and remove the rotten and let fresh grow, protect from infection, make the effect of wound healing fast.Treatment for scalding can reach rapid pain relieving, promotes new meat, the growth of new skin, prevents incrustation, the therapeutic effect of protecting from infection.