CN101371880B - Chinese medicinal composition for treating empyrosis wound surface - Google Patents
Chinese medicinal composition for treating empyrosis wound surface Download PDFInfo
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- CN101371880B CN101371880B CN2007101451662A CN200710145166A CN101371880B CN 101371880 B CN101371880 B CN 101371880B CN 2007101451662 A CN2007101451662 A CN 2007101451662A CN 200710145166 A CN200710145166 A CN 200710145166A CN 101371880 B CN101371880 B CN 101371880B
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Abstract
The invention discloses a traditional Chinese medicine composition for the treatment of burn and scald wounds, and the traditional Chinese medicine composition is mainly prepared by 3 parts of pearl, 7 parts of Chinese osbeckia herb, 7 parts of garden burnet root, 7 parts of Mongolian dandelion herb, 5 parts of frankincense and 5 parts of myrrh according to the mix ratio by parts by weight. The traditional Chinese medicine composition can be prepared into any one commonly used externally applied formulation. The traditional Chinese medicine composition has the functions of clearing heat, removing toxin, detumescence, relieving pain, eliminating slough, promoting granulation and astringency, the burn and scald wounds are healed rapidly by the treatment, the efficacy is high, and the traditional Chinese medicine composition can play the important adjuvant treatment roles on anti-inflammatory, anti-bacteria, anti-shock, anti-infection, prevention of the occurrence of sepsis and reduction of scars and scar contracture of the modern medicine aspect. The clinical observations of 365 cases of burns and scalds by the treatment of the traditional Chinese medicine composition do not find the occurrence of shock and sepsis and do not find the toxic reaction and the taboos to the traditional Chinese medicine composition.
Description
[technical field]
The present invention relates to a kind of Chinese medicine composition for the treatment of empyrosis wound surface, belong to the field of Chinese medicines.
[background technology]
The burn and scald case often has generation industrial on the national defence He in the family, and is clinical in empyema under burn wound's redness, pain, skin injury, sepage, eschar, the crust, and the liquefaction back forms ulcer, and healing back cicatrix and scar contracture are feature.Shock, part or systemic infection can appear in large-area burns, and septicemia can appear in malpractice.The doctor trained in Western medicine aspect is to the conventional debridement of wound surface, the local soak of normal saline or antibiotics liquid, or kpetrolatum gauze dressing wrapping, whole body is used antibiotics, fluid infusion, and crust is cut in operation, and the wound surface skin-grafting is treated, some case usually needed to be in hospital more than 3-6 month, and medical expense often needs several ten thousand～hundreds of thousands unit.Carry out Chinese herbal and crude drugs preparations the seventies energetically, as Cortex Ziziphi spinosae Radicis+80% ethanol, soak is sprayed on wound surface, and shortcoming is big to the wound surface zest, and pain is more violent, wound exudate, and empyema, shock, infection and septicemia often have generation under the crust.Chinese traditional treatment burn wound uses always and scalds fiery cream, JINGWANHONG RUANGAO, moistening ointment at present.List of references [1], yellow great, yellow virtuous, Liu Xusheng, electric burn clinical treatment 33 examples, China burn magazine 2003.6.183 treats in 33 examples, and 25 examples more than 2 months of being in hospital are in hospital 26 days shortest times, and are the longest 212 days, average 79.3 days.List of references [2], Sun Lekui, Zheng Zhenjie, Sun Lihua, MEBT treatment large-area burns 12 example reports, Chinese burn magazine 1996.1.31,12 examples adopt wet exposing therapy (MEBT) treatment, curative day, the shortest person 25 days, elder 80 days, average hospital days 40 days, wet treatment has shortened the natural law of being in hospital, and has received good effect.However, the time of burn treating healing is longer, and the cicatrix area is bigger, and these therapeutic effect still can not be satisfactory.
[summary of the invention]
Therefore, still there is demand in people's Chinese medicine preparation that curative effect is better treated empyrosis wound surface.Up to now, also do not find the report of any relevant Chinese medicine composition of the present invention.Handle a large amount of sepages of control wound surface, the generation of effectively preventing body fluid to lose and suffer a shock for burn wound, improve the body anti-infection ability, prevent septicemia, shorten the hospital stays, reduce cicatrix and prevent scar contracture, remain the important topic of domestic and international expert's research.Reported in literature: the albumin that the above burn of moderate begins to ooze out in the blood vessel in four days is equivalent to the twice of plasma protein amount; the quantity of " losing " also is quite surprising; so preventing body fluid loses; it is one of key of prevention shock; the protection wound surface; cut off antibacterial and invade the important channel of body; suppress antibacterial at the wound surface growth and breeding; protect from infection effectively and septicemia; be one of second key of treatment burn success or failure, thereby shorten treatment time, wound healing is fast; can make the wound surface preventing from scar or stay cicatrix less, purpose of the present invention just.The inventor is through the research repeatedly in more than 20 years, and the checking repeatedly by animal and clinical trial, found better the effectively Chinese medicine composition of treatment empyrosis wound surface finally, thereby finished the present invention.
The object of the invention just provides a kind of a kind of Chinese medicine composition of more effectively treating empyrosis wound surface.
Chinese medicine composition of the present invention selects Margarita, Herba Osbeckiae, Radix Sanguisorbae, Herba Taraxaci, Olibanum, Myrrha to make up, and with these Chinese medicine composition, makes each efficacy of drugs produce synergism, thereby can treat empyrosis wound surface effectively.Wherein select for use Margarita to be because the Margarita nature and flavor are sweet salty-cold, the function removing toxic substances and promoting granulation is controlled skin infection and is not received for a long time, scald to sprinkle burns, and skin lesion meat is mashed, gnawing pains take no rest person.Select Herba Osbeckiae, Radix Sanguisorbae, Herba Taraxaci, Olibanum, Myrrha for use, because the Herba Osbeckiae nature and flavor are hot flat, function hemostasis repercussive, the removing dampness of dispeling the wind, pain relieving, convergence, removing the necrotic tissue, eliminating blood stasis to promote regeneration of blood, reason skin infection.Radix Sanguisorbae nature and flavor picric acid, cold, is controlled haematemesis, epistaxis, incised wound, burn at function cooling blood for hemostasis, heat-clearing and toxic substances removing evacuation of pus.[pharmacology] antibacterial action, Radix Sanguisorbae has inhibitory action to staphylococcus aureus, bacillus pyocyaneus, beta hemolytic streptococcus in vitro.The Herba Taraxaci bitter but sweet flavor, cold, function heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, the furuncle carbuncle toxin, acute festering type infects, skin ulcer.[pharmacology] Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus Resistant strain, Hemolytic streptococcus in vitro, and Diplococcus pneumoniae, bacillus pyocyaneus, Bacillus proteus are also had certain bactericidal action.The Olibanum nature and flavor are arduous, warm, function regulating qi and activating blood, analgesic therapy, chase after poison.Control the carbuncle pyogenic infections from tumour or sore, coagulation of QI-blood, traumatic injury, skin infection pain.Myrrha nature and flavor hardship, flat, the function blood blood stasis removing that looses, subduing swelling and relieving pain, granulation promoting.Control and fall damage, incised wound, ulcer sore pain.These five tastes have heat-clearing and toxic substances removing, subduing swelling and relieving pain, and the hemostasis repercussive is removed the rotten and let fresh grow, and bacteria growing inhibiting and stronger bactericidal action are arranged on pharmacology, assists the Margarita removing toxic substances and promoting granulation jointly, controls skin infection and does not close up for a long time, treats to scald to sprinkle and burns the merit that skin lesion meat is mashed.
In order to reach best effect, Chinese medicine composition of the present invention also can make up with Folium Camelliae sinensis on the basis of said medicine, and this is because of the cold of Folium Camelliae sinensis bitter but sweet flavor, and the mashed skin ulcer of toe seam is controlled in the function detoxifcation.The pharmacological action of [pharmacology] Folium Camelliae sinensis still contains a large amount of tannic acids, convergence is arranged, bacteriostasis, Folium Camelliae sinensis preserved material or decoct are in test tube, various dysentery bacterium had antibacterial action, to staphylococcus aureus, beta hemolytic streptococcus, anthrax bacillus, bacillus subtilis, Bacillus proteus, bacillus pyocyaneus have bacteriostasis.Common assistant the monarch and his subjects' product have the merit of detoxifcation, convergence.This 7 flavor Chinese medicine is made up, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, the convergence effect is stronger, and the healing of treatment empyrosis wound surface is fast, and curative effect is higher.The generation that has antiinflammatory, antibiotic, shock, infection, prevention septicemia aspect modern medicine, preventing from scar or stay cicatrix less plays important auxiliary treatment effect.
The consumption of Chinese medicine composition component of the present invention also through the inventor grope in a large number, repetition test, the summary of experience that clinical observation draws, each amounts of components all has good curative effect in the following weight parts scope: 2～4 parts of Margaritas, 6～8 parts of Herba Osbeckiaes, 6～8 parts of Radix Sanguisorbaes, 6～8 parts of Herba Taraxacis, 4～6 parts of Olibanums, 4～6 parts of Myrrhas.
Be preferably: 3 parts of Margaritas, 7 parts of Herba Osbeckiaes, 7 parts of Radix Sanguisorbaes, 7 parts of Herba Taraxacis, 5 parts of Olibanums, 5 parts of Myrrhas.
The consumption of each component of Chinese medicine composition of the present invention can also be 2～4 parts of Margaritas, 6～8 parts of Herba Osbeckiaes, 6～8 parts of Radix Sanguisorbaes, 6～8 parts of Herba Taraxacis, 4～6 parts of Olibanums, 4～6 parts of Myrrhas, 2～4 parts of Folium Camelliae sinensis.
Be preferably 3 parts of Margaritas, 7 parts of Herba Osbeckiaes, 7 parts of Radix Sanguisorbaes, 7 parts of Herba Taraxacis, 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Folium Camelliae sinensis.
Margarita described in the present invention be with the Margarita of the Margarita of artificial cultivation or natural product all can, Folium Camelliae sinensis is to use green tea.
Chinese medicine composition of the present invention can be prepared into any conventional external preparation with the conventional method of Chinese medicine preparation.For example, these raw material pulverize mix homogeneously are made external pulvis, also these crude drug can be decocted except that Olibanum, Myrrha, Folium Camelliae sinensis together, down, decoct together again after Olibanum, Myrrha, the Folium Camelliae sinensis, concentrate decocting liquid then, make liquid for external use.But these can not be used to limit protection scope of the present invention.
Preferably, the preparation method of Chinese medicine composition active component of the present invention is as follows:
A) Margarita of described weight proportion is cleaned, is wrapped, boiled altogether about 2 hours, take out and clean, smash to pieces with bean curd and water with cloth, add water a little, be ground into impalpable powder, drying, must powder 1;
B) Herba Osbeckiae of described weight proportion, Radix Sanguisorbae, Herba Taraxaci 3 flavors are put in the pot heating respectively and are done and fry, fry to sallow, matter is crisp, and it is ground into fine powder, crosses 80～100 order sieve, powder 2;
C) Olibanum, the Myrrha of described weight proportion are put interior being heated to fully with slow fire of pot respectively and melted, taking-up cools, and is ground into fine powder, crosses 60～80 order sieve, gets fine powder 3;
D) merge powder 1, powder 2 and fine powder 3, with regard to the active component of preparation cost invention Chinese medicine composition
If adding Folium Camelliae sinensis, Chinese medicine composition of the present invention can be made liquor, and preparation method is:
A) Margarita of described weight proportion is cleaned, wrapped, boiled altogether about 24 hours, take out, clean, smash to pieces, get flour 1 with bean curd and water with cloth;
B) Margarita flour 1, Herba Osbeckiae, Radix Sanguisorbae, the Herba Taraxaci of described weight proportion put in the pot, added 10 times of amounts of water, decocted 1.5 hours, the Olibanum, Myrrha, the Folium Camelliae sinensis that add for the second time described weight proportion again, add 8 times of amounts of water, decocted 1 hour, and merged decocting liquid twice, reconcentration contains former Chinese medicine composition crude drug 0.8～1g to every milliliter, filter to get filtrate, just be prepared into the active component of Chinese medicine composition of the present invention.
Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, and reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, convergence, antiinflammatory, antibacterial functions are used for the treatment of empyrosis wound surface.
[specific embodiment]
Further set forth the curative effect of Chinese medicine composition of the present invention below by the test example, these test examples have comprised the pharmacodynamics test and the clinical observation on the therapeutic effect test of Chinese medicine composition of the present invention.
[test example 1] Chinese medicine composition of the present invention is split the therapeutical effect of the rat skin wound surface of scald
Test material:
Anthology invention Chinese medicine composition, normal saline, JINGWANHONG RUANGAO, lot number: 970901
Test method:
Get 48 of rats, male and female are regardless of, body weight 200～300 grams, behind amobarbital sodium (30mg/kg) intraperitoneal injection of anesthesia, 91 ℃ of 18 seconds of hot water are immersed at the back, cause dark II degree scalding area to reach 40% burned rats model, after the modeling rat evenly is divided into 3 groups, 16 every group, wherein matched group normal saline soak, comparable group is for using JINGWANHONG RUANGAO (lot number: 970901), the administration group is used Chinese medicine composition, respectively it evenly is coated with skim in wound surface, every day 2 times outward, observe local red and swollen symptom every day, what of exudate, the wound healing and the back cicatrix situation that heals.
The result shows that the local redness that occurs has vesicle, skin injury, sepage after the rat modeling.White secretions sepage appearred in second day in matched group to be increased, and a small amount of white secretions and sepage appear in comparable group, and the incrustation of administration group beginning in 12 hours wound surface, drying.Observed result sees Table 1.
The dark II degree three of table 1 is formed the face healing rate
Annotate: 1. administration group and matched group compare 2. criterion of cure of P＜0.01: modeling wound surface decrustation healing is standard.
The result shows, perusal as seen, administration group and matched group and comparable group relatively, Chinese medicine composition of the present invention has the obvious treatment effect to scald wound due to the hot water.
The clinical observation of [test example 2] traditional Chinese medicine composition for treating of the present invention burn wound.
1, physical data
Accept case wherein male 207 examples of totally 365 examples (comprise be in hospital, outpatient service, family's condition under) for medical treatment, woman's 158 examples, minimum 2 months of age, maximum 73 years old age, 29.3 years old mean age, burn surface area maximum 86%, minimum 0.8%, depth of burn: shallow II degree wound surface 185 examples, dark II degree wound surface 133 examples, III degree wound surface 47 examples, it is the shortest 25 minutes to accepting this traditional Chinese medicine composition for treating time started to burn, maximum duration 92 days.Burn cause: scald 219 examples, flame burn 109 examples, electric burn 13 examples, chemical burn 24 examples.All patients are divided into administration group (253 example) and matched group (112 example), and matched group use JINGWANHONG RUANGAO (lot number: 970901), administration group Chinese medicine composition of the present invention.Two groups of patient's age, sex and depth of burn area are close substantially, agents area symmetry or identical, its difference there are no significant meaning (P＞0.05)
2, diagnostic criteria
(1) tcm diagnosis standard
(a) the lighter's erubescence, little swollen pain, xerostomia happiness drink, red tongue is done, yellow and greasy fur, full and large pulse number.
(b) weight person's palor or coke black swell and ache, high fever, agitation, and body of the tongue is done, the rough full and large pulse number of yellow fur.
(2) Western medicine diagnose standard
(a) I degree burn: slightly red, swollen, bitterly, hot, wound surface is dry.
(b) light degree burn: local obviously red and swollen, skin blister differs in size, and removes the peel ruddy humidity, severe pain, edema.
(c) deep: local swelling, moistening, epidermis is whiter or pale brown, and the peeling wound surface is red thoroughly in white, and blister is little, and is insensitive.
(d) III degree burn: wound surface leather sample, pale or sallow carbonization, no blister, visible subcutaneous vascular embolization net.
3, Therapeutic Method
(1) wound exudate, the skin lesion or the person that has the purulent secretion, the bromo geramine liquid with 0.1% cleans wound surface, is coated with skim outward in wound surface with Chinese medicine composition composition powders of the present invention, takes exposure method.
(2) the dry no sepage person of wound surface behind the local routine disinfection, is coated with skim outward with Chinese medicine composition liquor of the present invention and takes exposure method in wound surface.
(3) large-area burns patient uses Western medicine antibiotics, fluid-supplement therapy simultaneously.
4, efficacy assessment standard
With the natural law of curing and the local cicatrix size in back that heals is the efficacy evaluation method.
5, therapeutic outcome (seeing Table 2)
Table 2: how many comparisons of shallow II degree and dark two kinds of wound healing times of II degree and cicatrix
Annotate: compare P＜0.01 with matched group wound surface of the same race
Clinical observation result shows that administration group and matched group compare, and the healing time of traditional Chinese medicine composition for treating empyrosis wound surface of the present invention (natural law) has obvious shortening treatment time and more obviously minimizing effect of back cicatrix.In the 365 routine clinical observations of treatment burn and scald, shock and septicemia did not all take place, and do not find toxic reaction of this Chinese medicine composition and taboo person.
Come further to set forth the preparation method of Chinese medicine composition of the present invention by the following examples.
The external pulvis preparation of [embodiment 1] Chinese medicine composition of the present invention.
(a) Margarita 3g is cleaned, wraps, boiled altogether about 2 hours, take out cleanly, smash to pieces with bean curd and water with cloth, add water a little, be ground into impalpable powder, drying makes powder 1;
(b) with Herba Osbeckiae 7g, Radix Sanguisorbae 7g, Herba Taraxaci 7g, 3 flavor medicines are put medicine pot internal heating respectively and are done stir-fry, and stir-fry is extremely sallow, matter is crisp, is ground into fine powder and crosses 80-100 order sieve, makes powder 2;
(c) Olibanum 5g, Myrrha 5g are put interior being heated to fully with slow fire of pot respectively and melt, taking-up cools, and is ground into fine powder and crosses 60-80 order sieve, makes fine powder 3;
(d) merge powder 1, powder 2 and fine powder 3, with its mix homogeneously, sterilization, the bottle of packing into, external pulvis is made in sealing.
The liquid for external use preparation of [embodiment 2] Chinese medicine composition of the present invention
(a) get Margarita 3g edulcoration, wrap,, take out and clean, smash to pieces, make Margarita flour 1 with about 2 hours of bean curd and decocting in water with cloth;
(b) get (a) Margarita flour 1, Herba Osbeckiae 7g, Radix Sanguisorbae 7g, Herba Taraxaci 7g, put and add 10 times of amounts of water in the pot, decocted 1.5 hours, for the second time add Olibanum 5g, Myrrha 5g, Folium Camelliae sinensis 3g, add 8 times of amounts of water again, decocted 1 hour, merge decocting liquid twice, reconcentration to every milliliter of medicinal liquid contains former Chinese medicine composition crude drug 0.8-1g, filters to get filtrate, and leaves standstill 24 hours, liquid for external use is made in bottling, sterilization, sealing.
Claims (4)
1. a Chinese medicine composition for the treatment of empyrosis wound surface is characterized in that it mainly is to be made by following bulk drugs: Margarita 2-4 part, Herba Osbeckiae 6-8 part, Radix Sanguisorbae 6-8 part, Herba Taraxaci 6-8 part, Olibanum 4-6 part, Myrrha 4-6 part.
2. according to the Chinese medicine composition of claim 1, wherein the consumption of each crude drug is: 3 parts of Margaritas, 7 parts of Herba Osbeckiaes, 7 parts of Radix Sanguisorbaes, 7 parts of Herba Taraxacis, 5 parts of Olibanums, 5 parts of Myrrhas.
3. Chinese medicine composition according to claim 1, wherein crude drug also has: Folium Camelliae sinensis 2-4 part.
4. Chinese medicine composition according to claim 3, wherein the consumption of each crude drug is: 3 parts of Margaritas, 7 parts of Herba Osbeckiaes, 7 parts of Radix Sanguisorbaes, 7 parts of Herba Taraxacis, 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Folium Camelliae sinensis.
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| CN2007101451662A CN101371880B (en) | 2007-08-22 | 2007-08-22 | Chinese medicinal composition for treating empyrosis wound surface |
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| CN2007101451662A CN101371880B (en) | 2007-08-22 | 2007-08-22 | Chinese medicinal composition for treating empyrosis wound surface |
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| CN101371880A CN101371880A (en) | 2009-02-25 |
| CN101371880B true CN101371880B (en) | 2010-12-08 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071050A (en) * | 2012-09-24 | 2013-05-01 | 吴江市精工铝字制造厂 | Traditional Chinese medicine ointment for burns |
| CN106177310A (en) * | 2016-08-23 | 2016-12-07 | 周淀 | A kind of moist expose burn ointment and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105871A (en) * | 1994-01-25 | 1995-08-02 | 陈宝玉 | Chinese-medicinal preparation for treatment of burn and scald and preparation method |
| CN1709287A (en) * | 2004-06-16 | 2005-12-21 | 潘知福 | Skin medicinal powder/ointment for burn and empyrosis |
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2007
- 2007-08-22 CN CN2007101451662A patent/CN101371880B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105871A (en) * | 1994-01-25 | 1995-08-02 | 陈宝玉 | Chinese-medicinal preparation for treatment of burn and scald and preparation method |
| CN1709287A (en) * | 2004-06-16 | 2005-12-21 | 潘知福 | Skin medicinal powder/ointment for burn and empyrosis |
Non-Patent Citations (3)
| Title |
|---|
| 左亚杰 等.烧伤药物的研究进展.《湖南中医药导报》.2002,第8卷(第3期),第106-108页. |
| 左亚杰等.烧伤药物的研究进展.《湖南中医药导报》.2002,第8卷(第3期),第106-108页. * |
| 陈华良.珍珠散治疗烫伤肉芽创面62例.《四川中医》.2004,第22卷(第5期),第80页. * |
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