CN102872335A

CN102872335A - Externally used Chinese medicine preparation for curing diabetic foot and preparation method thereof

Info

Publication number: CN102872335A
Application number: CN2012103196452A
Authority: CN
Inventors: 孙向红
Original assignee: 杨高林
Current assignee: Baicaotang pharmaceutical Limited by Share Ltd
Priority date: 2012-08-31
Filing date: 2012-08-31
Publication date: 2013-01-16
Anticipated expiration: 2032-08-31
Also published as: CN102872335B

Abstract

The invention discloses an externally used Chinese medicine preparation for curing diabetic foot, which comprises the following materials: 10 to 30 parts of psoralea fruit, 10 to 30 parts of purslane, 10 to 30 parts of clematis root, 10 to 30 parts of notoginseng, 10 to 30 parts of frankincense, 10 to 30 parts of myrrh, 10 to 30 parts of rhubarb, 10 to 30 parts of yellow corktree bark, 10 to 30 parts of calamine, 10 to 30 parts of cortex dictamni radicis, 10 to 30 parts of fired garden burnet, 10 to 30 parts of safflower, 10 to 30 parts of broom cypress, 10 to 30 parts of hyacinth bletilla, 10 to 30 parts of rhizome of drynaria, 10 to 30 parts of Chinese angelica root, 10 to 30 parts of earthworm, and 10 to 30 parts of minium. The externally used Chinese medicine preparation promotes local blood circulation and the growth of granulation tissue, and protects wounded area, prevents the wounded area from being rubbed and collided, can also isolate the wounded area from the environment, and reduce the occurrence rate of bacterial infection, thereby being capable of greatly improving the curative ratio of DF, and obviously reducing the healing time of ulcer surfaces. Obvious untoward reactions are not discovered during treatment, so that the externally used Chinese medicine preparation is safe and effective to be applied to clinical work, and is worth of further amplification.

Description

A kind of Chinese medicine for outer use for the treatment of diabetic foot and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine for outer use for the treatment of diabetic foot and preparation method thereof.

Background technology

The foot of diabetics causes the pathological changes such as pain, skin deep part ulcer, acromelic gangrene because of many factors such as blood supply insufficiency and antibacterial infection.Such disease is medically being named " diabetic foot " (being commonly called as " always mashed foot ").Suffering from the people of diabetes more than 5 years must enhance your vigilance to this disease, and will regularly do necessary inspection, to understand the situation of lower limb vascular and neuropathy.Over nearly 20 years, the pathogenetic understanding of China's traditional Chinese medical science bound pair diabetic foot in system progressively deeply.The cause of disease of DF is Lower Distal Extremities neuropathy due to the diabetes and the comprehensive pathological change of Lower Distal Extremities vascular lesion, the pathophysiological change that its skin of lower extremity and tissue injury occur on the basis of metabolism disorder and blood vessel, neuropathy often.Representational doctor family points out that basis of diabetic foot is deficiency of both QI and YIN, and different TCM syndrome types is blood stasis due to qi deficiency, and standard card is that damp and hot heap soil or fertilizer over and around the roots is contained, and the development trend of vascular lesion and syndrome of blood stasis increases progressively by the order of deficiency of both QI and YIN, blood stasis due to qi deficiency, damp and hot heap soil or fertilizer over and around the roots Sheng, and the state of an illness also increases the weight of thereupon.During this patient is according to the observation, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., pathogenesis is the blood stasis stagnation of phlegm, healthy energy is deficient.

Also have the doctor to think that primary disease mainly is deficiency of both QI and YIN, the passages through which vital energy circulates stasis blocking due to the acra mistake is supported, always belongs to the card of deficiency in origin and excess in superficiality, and take deficiency of both QI and YIN as this, the passages through which vital energy circulates stasis blocking is mark.Spleen, kidney two void, coagulation of QI-blood, meridians intercept, and the yang deficiency blood stasis is that the primary disease morbidity is basic.Primary disease is started in quenching one's thirst, and belongs to hyperactivity of fire caused by deficiency of YIN, and heat Tianjin blood that burns leads to blood stasis, cause limbs to lose and support, the evil poison of multiple sense, so acra fester and form necrosis, its basic pathogenesis is weakened body resistance blood stasis, accumulates in the pyretic toxicity.According to the clinical observation to diabetic foot tendon degeneration necrosis disease (muscle cellulitis), point out that its pathogenesis is: old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Think the early stage deficiency of both QI and YIN of primary disease, the venation discord, mid-term, deficiency of qi and blood accumulate in the noxious dampness, late period the hepatic and renal YIN deficiency, the stagnation of phlegm blood stasis.

The pathogenesis of diabetic foot mainly ascribes heat and the stasis of blood to, and the cloudy liquid virtual loss of diabetics is given birth in the deficiency-heat, and the consumption body fluid that burns forms the stasis of blood, or disease damage and sun, so that deficiency of both YIN and YANG, and yang deficiency cold coagulation and cause the stasis of blood; Blockage of the vessel, failure of skin and muscle to be nourished, apathy is subject to wound, the exopathogen invasion of taking advantage of a weak point in opponent's defence, strongly fragrant and heat-transformation, or because of the polyphagia delicious food, endogenous dampness, moist dysentery, the damp and hot stasis of blood is knot and falling ill mutually.

Diabetic foot refers to the large small artery of diabetics whole body, particularly the artery of lower extremity sclerosis of blood vessels causes that thrombosis appears in small artery on every side, form angiostenosis and obturation, cause patient's foot blood supply insufficiency, add diabetic neuropathy and the foot anaesthesia that causes and a kind of severe complication of damage.Its pathological changes main damage meridians, blood vessel, skin, tendon, even skeleton make the patient show as intermittent claudication, lower limb tranquillization pain, and severe patient skin ulceration, withered, blackening, even the foot gangrene occurs and cause amputation to disable.

Because diabetics is in hyperglycemia state for a long time, glycolated hemoglobin is high, and the erythrocyte oxygen carrying capacity is poor, and blood viscosity increases, and causes sclerosis of blood vessels, becomes fragile, thickens, and the ability of red blood cell deformation descends, and blood supply is not enough; On the other hand, the blood viscosity increase also causes vascular inflammation, more than many reasons, can cause the vascularization thrombosis, cause blood vessel to produce inaccessible phenomenon, cause blood supply seriously to lack, the local organization malnutrition of foot, because " foot " is centrifugal farthest dirty, the vascular occlusion phenomenon is the most serious, be easy to cause edema, blackout, rotten, downright bad, it is downright bad to form foot.

Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat and weaken even disappear, Abnormal Blood Rheology, whole blood viscosity increases, the platelet aggregation ability increases, and clotting mechanism is unusual, and fibrin increases, fibrinbioplast reduces, and microcirculation disturbance, loop eject existing tuberosity, the pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and the nipple, ecchymosis etc. appears in loop week, and microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

The traditional Chinese medical science is emphasized " disease is not controlled first, and anti-overweighting controlled ", and the generation of prevent diabetes foot is more urgent and important more than the treatment diabetic foot.Studies show that scalding and wear improper footgear and pruning toenail improper etc. is the physical factor that causes diabetic foot.The patient should forbid that foot is placed hot water bag or heat is filled up, and avoids scalding foot; Should wear soft, the loose ventilative shoes of the matter of fitting, avoid light to wear footwear, shoes can not be uneven, crackle is arranged, and changes every other day the footwear money, in order to avoid the long-term pressurized of foot's same position as far as possible.Can not pass tight shoes and socks, in order to avoid affect the blood circulation of foot: use file when pruning toenail and with vertical direction toenail is polished.After foaming foot, use bibulous towel and softly and thoroughly dry, especially should keep dry between toe space.Can not the Overexertion friction, to avoid skin injury.So strengthen the educational propaganda of pedopathy, the self-foot health promotion consciousness and the ability that improve diabetics are particularly important.

Doctor trained in Western medicine can not solve the sufferer misery for this disease at all, and 15%～25% ulcer of foot is in various degree arranged in diabetics, wherein about 1% patient because of the development of ulcer finally by amputation.In a word, Chinese medicine comprehensive treating diabetes foot has been obtained certain curative effect clinically, has tentatively demonstrated significant advantage; But effectively prescription needs dialectical use, and specific aim is relatively poor, and the clinical practice degree is not high.

Summary of the invention

Technical problem to be solved by this invention is, a kind of patient's of alleviating slight illness is provided, and wound healing reduces amputation rate, improves patients ' life quality purpose Chinese medicine for external application; The present invention adopts the Chinese crude drug of different properties, dispelling cold by warming the meridian; Stasis-dispelling and pain-killing; Blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting can improve the local blood capillary obstacle of lower limb, and blood circulation promoting comes off slough as early as possible, reaches tissue repair; To prevent simultaneously foot to infect the enhancing human body immunity function; The external application of Chinese medicine can improve the ulcer surface microcirculation effectively, increases the groundwater increment of local organization, promotes the regeneration of inflammation absorption and granulation tissue and epithelium, reaches the purpose of ulcer surface wound healing.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for outer use for the treatment of diabetic foot, it is characterized in that, the ratio of weight and number of various crude drug is in the described external preparation: 10～30 parts of Fructus Psoraleaes, 10～30 parts of Herba Portulacaes, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of Calaminas, 10～30 parts of Cortex Dictamnis, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of the Fructus Kochiae, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Pheretimas, 10～30 parts of Plumbum preparatiums.

The Chinese medicine for outer use of described treatment diabetic foot, the ratio of weight and number of various crude drug is in its described external preparation: 10～20 parts of Fructus Psoraleaes, 10～20 parts of Herba Portulacaes, 10～20 parts of Radix Clematidis, 10～20 parts of Radix Notoginseng, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Cortex Phellodendris, 10～20 parts of Calaminas, 10～15 parts of Cortex Dictamnis, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts on Flos Carthami, 10～15 parts of the Fructus Kochiae, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pheretimas, 10～15 parts of Plumbum preparatiums.

The Chinese medicine for outer use of described treatment diabetic foot, the ratio of weight and number of various crude drug is in its described external preparation: 10～15 parts of Fructus Psoraleaes, 10～15 parts of Herba Portulacaes, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～15 parts of Calaminas, 10～20 parts of Cortex Dictamnis, 10～20 parts of Radix Sanguisorbae preparatas, 10～20 parts on Flos Carthami, 10～20 parts of the Fructus Kochiae, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pheretimas, 10～20 parts of Plumbum preparatiums.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for outer use dosage form for the treatment of diabetic foot, described dosage form includes but are not limited to: unguentum, spray, liniment, loose powder agent, smear ointment, tincture or gauze agent.

For solving the problems of the technologies described above, the invention provides a kind of preparation method for the treatment of the Chinese medicine for outer use dosage form of diabetic foot, when the dosage form of described medicine is unguentum, preparation method comprises:

A. the crude drug of getting above-mentioned ratio of weight and number is put into Oleum Sesami and is soaked except Plumbum preparatium and Calamina; Heating is tempered;

B. will fry good Plumbum preparatium puts into medicine oil and stirs into paste;

C. the ointment that makes is put into releasing fire-toxin in the cold water, add Calamina.

Among the described step a, can add in the Oleum Sesami of 5-10 times of weight portion by the crude drug of described ratio of weight and number and soak 7-10 days; With the soaked crude drug heating extraction of Oleum Sesami, big fire is boiled, and firepower reduces after the Oleum Sesami boiling, endures to the crude drug appearance to be dark brown, and inner coke yellow is pulled medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl.

Among the described step b, the Plumbum preparatium can be fried to dark yellow, remove moisture, cross 100 orders-120 mesh sieve and remove impurity; The Plumbum preparatium is added in the good medicine oil of refining, constantly stir, become the thick paste of black.

Among the described step c, can soak 5-10 days in the impouring cold water after the cooling of black thick paste, change water every day once, releasing fire-toxin mixes the Calamina of pulverizing.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine for outer use dosage form of diabetic foot, the dosage form of described medicine is liniment, preparation method comprises: described crude drug is added soak with ethanol 1-2 hour except Plumbum preparatium and Calamina, heating was boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds ethanol and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Merge three times extracting solution, be concentrated into relative density and be 1.08 concentrated solution; Filter, left standstill 24 hours, after remove supernatant, get concentrated medicament; Plumbum preparatium and Calamina are broken into fine powder, drop in the concentrated medicament, mediation 70%-80% vaseline, tinning.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine for outer use dosage form of diabetic foot, the dosage form of described medicine is powder, and preparation method comprises: according to the ratio of weight and number of described crude drug with Radix Clematidis, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction stand for standby use; During extraction, use first the soak with ethanol of 70%-80%, rear 60～80 ℃ of heating extraction 2 times, each 1 hour; 10 times of amounts of the gross weight of used ethanol and Radix Clematidis, Radix Notoginseng and three kinds of medical materials of the Pseudobulbus Bletillae (Rhizoma Bletillae); The concentrated ethanol extract of heating, 1.06 concentrated solution when being concentrated into relative density and being 20 ℃.All the other described components are mixed by proportioning except Plumbum preparatium and Calamina, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flooded 10～15 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and are then mixed with aforementioned concentrated solution; Described mixed liquid heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, mix Plumbum preparatium and the Calamina of pulverizing and make powder.

For solving the problems of the technologies described above, it is its using method of loose powder agent that the present invention also provides a kind of exterior-applied formulation of diabetic foot: can clean the skin ulcer face with 3% hydrogen peroxide first first, wipe out slough, clean with normal saline, periphery skin 75% alcohol disinfecting, then with loose powder agent of the present invention, be dispersed in equably on the skin ulcer face, to cover and to surpass whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

Or use the gentamycin soak, and method is: gentamycin 240,000 u are diluted in the 50ml normal saline, spread on ulcer surface after sterile gauze is soaked, and 2～3 layers of sterile gauze of enclosing cover are fixed with Breathable adhesive tape, change dressings 1 day 1 time; Treating 20 days is 1 course for the treatment of.

The present invention selects corresponding prescription according to patient's disease, and one aspect of the present invention promotes the growth of local blood circulation and granulation tissue; Protect on the other hand wound surface, avoid being subject to frictional impact, can also be isolated from the outside, reduce the generation that antibacterial infects, thereby can greatly improve the cure rate of DF, obviously shorten the ulcer surface healing time.And during treating, do not find obvious adverse reaction, so be used for clinical safety, effective, be worth into a popularization.The present invention is Chinese medicine preparation, can reach to alleviate patient's slight illness, and wound healing reduces amputation rate, improves the patients ' life quality purpose; The present invention adopts the Chinese crude drug of different properties, benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting comes off slough as early as possible, reaches tissue repair; To prevent simultaneously foot to infect the enhancing human body immunity function; External application can improve the ulcer surface microcirculation effectively, increases the groundwater increment of local organization, promotes the regeneration of inflammation absorption and granulation tissue and epithelium, reaches the purpose of ulcer surface wound healing.The present invention is evident in efficacy, and clinic is applied.

The specific embodiment

World Health Organization (WHO) to the definition of diabetic foot is: the lower limb that neuropathy and various in various degree peripheral vessel pathological changes cause infect diabetics owing to merging, ulcer (or) deep tissue destroys.Its Early manifestation is that pedal skin is dry, antiperspirant is few or the pain athalposis, develops into then that toe festers, infection, blackout, necrosis, and is diffused into very soon healthy toe, finally disable, even threat to life.Therefore the active treatment diabetes are controlled blood glucose, and prevention and treatment are infected, and in time treat local the grade and are the Primary Care measure of primary disease.Primary disease belong to the traditional Chinese medical science it " quench one's thirst ", the category such as " necrosis ".Motherland's medical science thinks that primary disease is owing to coagulation of QI-blood, venation block, and with the passing of time heat-transformation, intenseness of heat then meat is rotten, rottenness of muscle forming pus, causing eventually festers does not heal.So, to classify from clinical manifestation, primary disease belongs to again the surgery category." medical science source and course " has saying of " method of surgery, the heaviest external treatment ", so we cooperate the local external application of Chinese medicine SHENGJISAN on the basis of conventional medical treatment.

The Chinese medicine ancient medicine has many discussions and record to diabetes complicated carbuncle.Diabetic foot belongs to the accompanied symptoms " necrosis " of traditional Chinese medical science diabetes.About in diabetes patient concurrent " necrosis " traditional Chinese medical science ancient books many discussions being arranged.Tang's Sun Simiao " prescriptions worth thousand gold " has the record of " people who quenches one's thirst is healed and do not healed, and often pondering over has large carbuncle, and the people that whichever is quenched one's thirst must finally, die in large carbuncle also so guard against in DAGU internode generation carbuncle ".Sui Dynasty's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " record, diabetes has eight times, comprising " carbuncle ".The Wang Tao Tang Dynasty " medical secrets of official " record, " diabetes ... multiple carbuncle ".Yuan Dynasty Zhu Rui chapter " precious mirror of hygiene " record " person's of quenching one's thirst foot knee joint is sent out malignant boil, to stubbornly refuse rescue " ....Unit's Zhu Zhenheng " danxi's experiential therapy " has been put down in writing the clinical symptoms of diabetes necrosiss in detail, point out " necrosis is born between the toes ... nascent such as the foxtail millet Rubus pectinellus some color of the leather is purple dark, and just as boiling Fructus Jujubae, black gas spreads, rot to prolong out ... sprinkle the fire combustion just as soup ".

The traditional Chinese medical science thinks roughly that to the pathogenic inducement of diabetic foot three aspects are arranged: the heresy of (1) impression cold.The diabetics foot is subjected to the heresy of cold, or paddles and drop down the river or sense is cold or sweating entry or field, snow day are slept in the open etc., all can cause the cold-evil to attack outward, coagulation of QI-blood, passages through which vital energy circulates impatency and falling ill ....What we added up that prompting directly causes by catching a cold accounts for 7%～9% of patient's number; (2) the burning hot heresy of impression.Diabetics, the deficiency of YIN are this, scorchingly experience again burning hot heresy for mark, and be then cloudy empty, scorchingly more contains, and burning hot heresy is gathered in the part, corrosion flesh and blood and be pus of carbuncle.We add up prompting and account for 13%～15% of patient's number by what the burning hot heresy of impression such as burn and scald caused; (3) external injury.External injury on the direct occurrence cause of diabetic foot in the highest flight, various external injuries (friction injury, prune accidentally, foreign object damage, callus, mosquito bite, iatrogenic injury, postoperative do not heal) directly injure human body, cause local coagulation of QI-blood, or because of after the damage, cause the passages through which vital energy circulates stasis blocking, QI-blood circulation is not normal and fall ill.External injury causes the patient and accounts for more than 60% of patient's number according to statistics.

Chinese medicine thinks that the pathogenesis of primary disease mainly is to quench one's thirst with the passing of time, deficiency of both QI and YIN, passages through which vital energy circulates stasis blocking, hematogenous blockage, acra lose supports, in addition damp invasion of lower energizer, the pyretic toxicity blood stasis forms BI-syndrome involved the blood vessels, necrosis, and is specific as follows: stagnation of blood stasis, with the passing of time the resistance of venation numbness quenches one's thirst, because of scorching in the deficiency of YIN, and cloudy liquid virtual loss, scorching inclined to one side Sheng, the bright Tianjin of heat blood, and hyperamization liquid is concentrated, blood viscous, the not smooth stasis of blood of blood is slow, or because scorching yin-damaging and Qi consuming, make deficiency of both QI and YIN, be difficult to transport blood, blood is unable, or because cloudy liquid virtual loss, deficiency of YIN affecting YANG, yang deficiency cold coagulation, blood vessels are lost in warm, all can make hematogenous blockage, form blood stasis.Blood stasis is in case form, because of the resistance of blood vessels numbness, hematogenous blockage cause the limbs part especially acra lose and support and form BI-syndrome involved the blood vessels, necrosis.Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat and weaken even disappear, Abnormal Blood Rheology, whole blood viscosity increases, the platelet aggregation ability increases, and clotting mechanism is unusual, and fibrin increases, fibrinbioplast reduces, and microcirculation disturbance, loop eject existing tuberosity, the pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and the nipple, ecchymosis etc. appears in loop week, and microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

The observational study of diabetic foot different lesions stage clinical symptoms, tongue pulse condition and tcm syndrome is found that diabetic feet is in early days take void as main according to us, take deficiency of qi and yin or yang-energy virtual loss as common, accompanied blood stasis and venation discord; Patient's syndrome performance in mid-term is complicated, if invade in the exopathogen, healthy energy remains, and struggle between vital QI and pathogen shows take the domination of pathogen as main, with dampness-heat in the liver and gallbladder, and dominance of heat in the interior, it is main accumulateing in the noxious dampness, if healthy energy virtual loss, then simulataneous insufficiency and excessive; The many courses of disease of the patient in late period are both of a specified duration, and consumption is hindered healthy energy, and simulataneous insufficiency and excessive is pressed from both sides the mutual resistance of the expectorant stasis of blood as main take the hepatic and renal YIN deficiency or deficiency of spleen-YANG and kidneyYANG.Diabetic foot can occur in diabetes the moon thanks to scorching, deficiency of both QI and YIN, deficiency in both YIN and YANG stages, and blood stasis is the important pathologic basis of its genesis, and multifarious external injury occupies an important position in the diabetic foot morbidity.Present research prompting, diabetics are on the pathologic basis of deficiency of both QI and YIN, and the deficiency of vital energy is without trying hard to recommend the blood operation, and thrombosis or obstruction sering cause the stasis of blood; Hyperactivity of fire caused by deficiency of YIN decocts body fluid, makes blood viscid, and operation does not freely cause the stasis of blood; After blood stasis formed: (1) blood lost the nutrition of histoorgan and moistens effect; (2) blood stasis is difficult carrier gas in interior, defends gas and loses it and normally defend the functions such as outer; (3) blood stasis hinders in the part, strongly fragrant and heat-transformation, more cause deficiency of YIN leading to consumption of QI, very the person becomes the poison of stagnant heat. in the sunset paathogenic factor, the evil cold coagulation of cold causes the stasis of blood and increases the weight of the state of an illness, but external injury direct effect part causes coagulation of QI-blood, and pathogenic heat, damp, malicious heresy are invaded into pyretic toxicity, diseases caused by noxions dampness, is combined with local pathological product then to form hot and humid ecchymosis and become mutually trouble.It more than may be the main mechanism that diabetic foot causes a disease.

External used medicine has blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting, draw out the pus put on flesh, the effect of skin moistening granulation promoting.Be applicable to all suppurative wounds, slough does not take off or takes off, and new meat is the survivor not.Pheretima, disperse blood stasis and dredge collateral; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing; The good medicine of Flos Carthami promoting the flow of QI in the collateral by warming the meridian dissipating blood stasis; The property kind descending, but be longer than again stasis-dispelling and pain-killing of promoting blood circulation to remove obstruction in the collateral, and can assign the foot affected part by priming; Full side's benefiting QI and nourishing blood is with Zhi Qiben, and promoting the flow of QI in the collateral by warming the meridian must answer QI and blood to control its mark, and blood stasis must remove, qi and blood circulation, and the muscle arteries and veins is moistened foster, so all diseases are from removing.The Radix Et Rhizoma Rhei heat clearing away of reducing internal heat, broken stagnated blood, tissue regeneration promoting blood, Pheretima the meridian dredging have the effect of blood circulation promoting and blood stasis dispelling.All medicines cooperates, and makes altogether QI and blood fill Sheng, and short its corruption flesh of dispelling is given birth to open sore part convergence.The Pseudobulbus Bletillae (Rhizoma Bletillae) has putrefaction removing and tissue regeneration promoting, short merit more in the side, and blood vessel dilating is arranged, improves microcirculatory function; Plumbum preparatium removing dampness sore, granulation promoting are put on flesh; Sanguis Draxonis, Myrrha, the pain relieving of Olibanum promoting blood circulation to remove blood stasis, the hemostasia and promoting granulation sore is conducive to the granulation tissue growth.The external Herba Portulacae, Radix Clematidis has blood vessel dilating, promotes diaphoresis, the antibiotic effect of easing pain; The blood circulation promoting and blood stasis dispelling such as Flos Carthami have dense, glutinous, the state of aggregation that improve blood, and anticoagulant improves local microcirculation, make blood flow further unobstructed, improve local blood supply, oxygen supply, strengthen the recovery of Nerve conduction.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters the blood chamber, and delirium is gone mad; Or blood is vexed interior swollen, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.It is all that cold and heat are handed over work as amenorrhea is obstructed, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are long-pending, or skin infection sufferings and swollen burst uneasyly, be cards of disharmony between QI and blood all, non-Flos Carthami can not be transferred, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, the thrombosis of inhibition, antiinflammatory, analgesic effect are arranged, have the vasoconstrictive effect of eliminating epinephrine, norepinephrine, " tonneau passages through which vital energy circulates " effect is arranged.

Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.It is fanatical dry to cure mainly height, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis: it is active that Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen the platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses the plasmin enzymatic activity, and local hemorrhage is had anastalsis; Zoopery shows, the external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for the Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2. protection gastric mucosa: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, the rat pipe film injury that hydrochloric acid is caused has protective effect; Experimental Stomach duodenum perforation has therapeutical effect to anesthetized dog.3. antibiotic, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; The water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC 1057 and Trichophyton QM248.

Radix Et Rhizoma Rhei has another name called yellow good, fire ginseng, skin such as Wu Pu.Ancients are with its " main lower congestion, blood closes, cold and heat, broken lump in the abdomen, the prolonged fluid-retention dyspepsia is cleansed the intestines and stomach, pushes away Chen Zhixin, tonneau water paddy, relieving dyspepsia in the accent, peace and the five internal organs ".Radix Et Rhizoma Rhei is used for the treatment of burn, scalds at China's long history." book on Chinese herbal medicine cover mirror " record: " the yin aspect of yin was coagulated the soup clearly if grind chicken into powder, can apply burn and get effect Radix Et Rhizoma Rhei bitter in the mouth, gas Great Cold."; " medicine mirror " record: " large yellow maturity does not close up for a long time with then controlling all fire-toxin skin ulcers.Lid all belongs to fire-toxin with all malicious burn, and large yellow maturity usefulness then can be let out fire-toxin, and reducing swelling and alleviating pain." Compendium of Material Medica grass section the 17 volume Radix Et Rhizoma Rhei cures mainly lower record " Radix Et Rhizoma Rhei is controlled all burn."; Theory of Chinese medical science thinks that burn and scald is that fire-toxin is trouble, local coagulation of QI-blood, and meridians block, and putrefaction of blood and muscle forms, and Radix Et Rhizoma Rhei has the pathogenic fire purging of capturing, heat clearing away treating narcotic addiction, the key medicine that the removing heat from blood clots absorbing is the treatment burn, scald.Modern medicine also prove Radix Et Rhizoma Rhei have invigorate blood circulation, hemostasis, antibacterial, eliminate endotoxin, improve immunity of organisms, reduce the effects such as body temperature, analgesia.Radix Et Rhizoma Rhei contains anthraquinone, anthraquinone derivatives is stronger to staphylococcus, streptococcus antibacterial action; Tannin contained in the Radix Et Rhizoma Rhei has good astriction to wound surface, can promote the wound face healing.

Radix Sanguisorbae property of medicine picric acid; Cold; Nontoxic, return liver; Lung; Kidney; Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect classification hemorrhage; Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria is had blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, control the defecation blood disorder.Hemostasis is got and is cut off sheet and fry usefulness, and its tip then can promoting the circulation of blood, can not know.The Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.

Radix Sanguisorbae preparata: Radix Sanguisorbae dried be ground into superfine powder, sieve; Boil with Oleum Sesami (or vegetable oil) in addition, then rapid elm powder intensively stirs and makes into pasty state, and it is interior for subsequent use to be contained in sterile pot.Time spent directly is applied to wound surface with mass, can very fast formation 1 thick layer medicine crust, can play prevention and infection control, and eliminate pain promotes the effects such as wound surface heals rapidly.Generally be applicable to one, second degree burn, scalded patient.Radix Sanguisorbae contains a large amount of tannins, and stronger convergence and pressor effect are arranged, and can reduce the permeability of blood vessel, reduces inflammatory exudation, also has simultaneously obvious bactericidal action, can resist charrin's disease.Also can adopt Radix Sanguisorbae ethanol liquid (Radix Sanguisorbae is cleaned and to dry, and grinds coarser powder and extracts clear liquid with 70～75% ethanol percolation, boils to liquid level thin film to occur, cools off for subsequent use) to be coated with burn wound, every day 2～3 times, not wrap up.The coating number of times forms dry crusts and be full of cracks do not occur as degree take wound surface.To the wound surface that has the polluted debridement treatment of to go ahead of the rest.By one, the observation of second degree burn patient 40 examples; prove this method to superficial burns, special centering small size, to pollute lighter burn effect better, generally can form 1 layer of brown protecting film on the wound surface through 12～24 hours; this oozes out preventing germ contamination, minimizing wound surface, and good impact is all arranged.

The Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The Cortex Phellodendri nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency." Chinese pharmacopoeia is carried the power of Cortex Phellodendri heat clearing and damp drying, and is similar to Radix Scutellariae, Rhizoma Coptidis, but damp and hot as good take except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

The Myrrha blood blood stasis removing that falls apart, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, suffering, flat.1. " property of medicine opinion ": " bitter in the mouth is hot." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is hot, and temperature is nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." enter liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enter spleen, kidney two warps." 3. " book on Chinese herbal medicine is looked for the truth ": " enter the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness detoxifcation.

Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": it be swollen to treat the edema due to wind pathogen poison, removes bad odor.Treat the urticaria poison of itching.Supplement to the Herbal: treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only large intestine is let out Bleach, treats all skin ulcers and makes internal diabetes.Control to fall and pounce on the folding wound.

The Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Tradition thinks that Radix Clematidis has wind-damp dispelling, the meridian dredging, the bone that disappears three large effects of choking, because its property is walked to alter, the pharmacology confirms that it removes esophagus in addition, bronchus, ureter, stomach and biliary tract etc. are located the effect of smooth muscle spasm, and stronger anti-inflammatory analgetic effect arranged, hypoglycemic activity Radix Clematidis preserved material to normal rat have the assimilation of remarkable enhancing glucose effect (namely give rat with a large amount of glucoses after, the glucose in urine test is still negative), therefore hypoglycemic activity may be arranged. in vitro, the water logging agent has inhibitory action to dermatophytes. and the water logging agent also has inhibitory action to microsporon audouini; Decoct has inhibitory action to staphylococcus aureus, shigella. and the decoct lumbar injection can slightly improve the mice threshold of pain, points out it that analgesic activity is arranged. and decoct has inhibitory action to plasmodium. and alcohol extract has the induced labor effect to the mice midtrimester of pregnancy.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to hemostasia and dissipation blood stasis, reducing swelling and alleviating pain to have good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being considered as treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews namely ending of mashed net for catching birds or fish immediately, and bruise the person namely dissipate.If when being subjected to cane, take first one, two money, then the blood centre of punch not should take it behind the cane especially, and puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work because of blood stasis that blood ends because applying loose blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization.”

The Fructus Kochiae is cold in nature, acrid in the mouth, hardship.Function cures mainly] clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen." not Lu ": " steam in the peeling skin, loose malignant boil, the hernia abdominal mass, reinforcing YIN-essence makes the people moist.”

Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening continues and hinders pain relieving.Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, the muscle fracture wound; The external treatment alopecia areata, vitiligo." Japan hanako materia medica " carries it: control malignant boil, the mashed meat of erosion, parasite killing.The good medicine that surgery is used to remove the skin toxin.

Cortex Dictamni is the root bark of the dittany Dictammnus dasycar pusTurcz that plants of Rutaceae perennial herb.Dispel the wind dampness, heat clearing away, detoxifcation.Control the wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice." herbal classic ": main wind syndrome of head, jaundice, cough with dyspnea drenches drop, swells and ache the dead flesh of arthralgia chiefly caused by damp pathogen, unable to flex and stretch the extremities, start-stop, row step in woman's the moon." not Lu ": it be uneasy to treat extremity, the time too hot in the row abdomen, drink water, want to walk, call out, pediatric epilepsy scared, married woman's puerperal remaining pain." property of medicine opinion ": control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red mashed, and the eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, the high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy is yellow, labor is yellow etc." the Ministry of War in feudal China hands collection side ": treat lung and cough." Japan hanako materia medica ": get round by bribery, sharp nine orifices and blood vessels, and all migratory arthralgia muscles and bones are weak weary, and logical small intestinal aqueous vapor, disease during the sky row, the headache eye is painful.Root bark is good, and the flower function is the same." book on Chinese herbal medicine is original ": control all mange, aversion to wind, scabies, Fructus Myricae rubrae, all skin ulcer pyretic toxicity.

The Herba Portulacae inducing diuresis to remove edema reduces blood pressure.Herba Portulacae contains a large amount of potassium salt, and good inducing diuresis to remove edema effect is arranged; Potassium ion also can directly act on the blood vessel wall, makes the blood vessel wall expansion, stops ductus arteriosus wall to thicken, thereby plays the effect that reduces blood pressure.Medicinal function is heat-clearing and toxic substances removing, cooling blood for hemostasis.Because it contains abundant norepinephrine, can promote the pancreas islet gland excreting insulin, balance the body carbohydrate metabolism process, blood sugar lowering concentration, keep blood glucose constant, so diabetes are had certain therapeutical effect.In addition, it also contains a kind of unsaturated fatty acid that is called 3-W, can suppress the generation of cholesterol and triglyceride, and cardiovascular is had protective effect.Compendium of Material Medica: " it is treating stranguria to detoxify, the rear sweating due to debility of managing property for loose blood detumescence, sharp intestinal habitual abortion.”

Fructus Psoraleae nature and flavor: acrid in the mouth; Bitter; Warm in nature returning through kidney; Pericardium; Spleen; Stomach; The lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence is smart; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; The stool chronic diarrhea; Vitiligo; Speckle is bald; The psoriasis Fructus Psoraleae, the energy warming the kidney; Give birth to sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, being so incensed that to mend of kidney-Yang and rising in the kidney then then can digesting food, steam waste matter and change precise and tiny.Be attributed to lung on the spleen-QI transporting the essence to the whole body, support the five internal organs with honor, so the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the air-cooled visitor that takes advantage of a weak point in opponent's defence then so that bone marrow hinders and loses, the cold smart stream of kidney, and kidney governing bones store essential substances, marrow be smart this, the gas of kidney-Yang is solid, namely before card see, solid itself and yang-energy is living, then front card removes in vain.The man is take essence as main, and the married woman is take blood as main, married woman vim and vigour person, and also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, with the cold smart stream of man's kidney also.

The Plumbum preparatium is plumbous oxide Pb ₃O ₄Give birth to or fry and use.Another name: Plumbum preparatium, Plumbum preparatium, red powder, Zhen Dan, lead powder used in cosmetics.Acrid in the mouth is slightly cold.GUIXIN, Liver Channel.The external removing toxic substances and promoting granulation, preventing the attack (or recurrence) of malaria for oral administration.Be used for various skin ulcer furuncles, yellow fluid eczema, ulcer does not close up for a long time, venom, malaria, infantile convulsion is demented." detailed outline ": the Plumbum preparatium, body weight and property are heavy, and flavor hold concurrently salt, vitriol are walked blood system, can fall expectorant and go timidly, so it is demented to control infantile convulsion, tell converse stomach.Can eliminating stagnated food and killing intestinal worms, so control infantile malnutrition, dysentery, malaria solid cubic content is arranged.Can analgesic drawing out pus by applying a plaster to the affected part, the blood stasis removing of putting on flesh so control the malignant boil toxic swelling, and enters plaster, and the thing that must use for surgery is also.

Calamina is carbonate mineral calcite family smithsonite, the main zinc carbonate (ZnCO that contains ₃).After excavating, clean, dry, except roguing stone.This product character is block aggregation, is irregular bulk, canescence or pale red.The surface mealiness, tarnish, uneven, porous is like cellular.Body is light, and is frangible.Odorless, it is little puckery to distinguish the flavor of.Function cures mainly: detoxifcation improving acuity of vision and removing nebula, the antipruritic sore of removing dampness.Be used for conjunctival congestion and swelling pain, marginal blepharitis, nebula film bulbar conjunctiva polyp, ulcer being unable to heal, pus is dripping, eczema, skin pruritus.

The manufacturing process of externally used paste of the present invention is: get Fructus Psoraleae 2100g, Herba Portulacae 2200g, Radix Clematidis 1900g, Radix Notoginseng 2000g, Olibanum 2200g, Myrrha 1700g, Radix Et Rhizoma Rhei 1900g, Cortex Phellodendri 2100g, Cortex Dictamni 2200g, Radix Sanguisorbae preparata 1800g, Flos Carthami 2000g, Fructus Kochiae 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2100g, Rhizoma Drynariae 2000g, Radix Angelicae Sinensis 2200g, Pheretima 1800g adds by the crude drug of described ratio of weight and number in the Oleum Sesami of 5-10 times of weight portion and soaked 7-10 days; With the soaked crude drug heating extraction of Oleum Sesami, big fire is boiled, and firepower reduces after the Oleum Sesami boiling, endures to the crude drug appearance to be dark brown, and inner coke yellow is pulled medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl; Plumbum preparatium 3000g is fried to dark yellow, remove moisture, cross 100 orders-120 mesh sieve and remove impurity; The Plumbum preparatium is added in the good medicine oil of refining, constantly stir, become the thick paste of black; In impouring cold water after the cooling of black thick paste, soaked 5-10 days, change water every day once, releasing fire-toxin mixes the Calamina 2000g of pulverizing, makes unguentum.This product is fit to have sent out festers, prolonged not more and patient with diabetic feet.

Medicine for external use agent type is powder in the Chinese medicine preparation, and its preparation method comprises: first with Radix Clematidis 1800g and Radix Notoginseng 2100g water steam extraction method, make crystallization according to described portion rate; With all the other described component Fructus Psoraleae 2100g, Herba Portulacae 2100g, Olibanum 2000g, Myrrha 1700g, Radix Et Rhizoma Rhei 1900g, Cortex Phellodendri 1800g, Cortex Dictamni 1900g, Radix Sanguisorbae preparata 1900g, Flos Carthami 2000g, Fructus Kochiae 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2100g, Rhizoma Drynariae 2000g, Radix Angelicae Sinensis 2200g, Pheretima 1800g mixes by proportioning, drops into pulverizer and is ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, decocted 1-2 hour, filter; Filtering residue adds water and decocted 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, get filtrate after the separation, extracted twice liquid concentrate drying is become powder, mix the crystal that distillation obtains, even with mixing after Plumbum preparatium 2100g and the Calamina 2300g pulverizing again, behind ultraviolet radiation for sterilizing and disinfecting, make powder.

The preparation method of external gauze of the present invention agent: with described crude drug Fructus Psoraleae 2200g, Herba Portulacae 2200g, Radix Clematidis 1900g, Radix Notoginseng 2000g, Olibanum 2200g, Myrrha 1900g, Radix Et Rhizoma Rhei 2000g, Cortex Phellodendri 2100g, Cortex Dictamni 2200g, Radix Sanguisorbae preparata 1800g, Flos Carthami 2000g, Fructus Kochiae 2100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2000g, Rhizoma Drynariae 2000g, Radix Angelicae Sinensis 2200g, Pheretima 2000g, Plumbum preparatium 2000g, Calamina 1900g grinds to the powder altogether, crosses 120 mesh sieves, and coarse powder adds ethanol extraction once, be condensed into powder, two kinds of powder mixing add 70% vaseline accent and all are applied to aseptic dried sliver, put in the container, and are for subsequent use after the high pressure steam sterilization sterilization; Wound surface is changed dressings: behind the slough through thoroughly remove ulcer wound surface with surgical method 1～2 layer of sliver of the present invention spread on the wound surface, do not contact normal skin, the external use sterile gauze piece covers.

Using method is: first the skin ulcer face is cleaned with 3% hydrogen peroxide first, wipe out slough, clean with normal saline, then peripheral skin 75% alcohol disinfecting mixes the present invention breaking into fine powder again, be dispersed in equably on the skin ulcer face, to cover and to surpass whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

The dosage form of external is that the preparation method of liniment comprises: with described crude drug Fructus Psoraleae 2100g, Herba Portulacae 2100g, Radix Clematidis 2000g, Radix Notoginseng 2100g, Olibanum 2100g, Myrrha 1900g, Radix Et Rhizoma Rhei 2000g, Cortex Phellodendri 2100g, Cortex Dictamni 2200g, Radix Sanguisorbae preparata 1800g, Flos Carthami 2000g, Fructus Kochiae 2100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2000g, Rhizoma Drynariae 2000g, Radix Angelicae Sinensis 2100g, Pheretima 2100g adds soak with ethanol 1-2 hour, heating was boiled 30～40 minutes, filtered filtrate for later use; Filtering residue adds ethanol and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Merge three times extracting solution, be concentrated into relative density and be 1.08 concentrated solution; Filter, left standstill 24 hours, after remove supernatant, get concentrated medicament; Calamina 2500g and Plumbum preparatium 2000g are broken into fine powder, drop in the concentrated medicament, mediation 70%-80% vaseline, tinning.

External used medicine acute toxicity testing data

1, experimental technique

Guinea pig back spinal column both sides are evenly coated depilatory, make about 20 square centimeters of unhairing scope.Clean depilatory returns cage to observe 24 hours, every group of Cavia porcellus is coated with respectively externally used paste 4g of the present invention, 8g and 12g, contain respectively crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, and a continuous week is after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin are done pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin and contrast word more also no significant difference.

Results suggest, Chinese medicine for external application of the present invention also have no the general toxicity performance without local irritant effect.Show that Chinese medicine for external application of the present invention uses safety.

The long term toxicity test data

1, experimental technique

Cavia porcellus at random part is become 4 groups, 15 every group.In guinea pig back spinal column both sides depilatory is evenly coated, made about 20 square centimeters of its depilation scope.Clean depilatory, observe after 24 hours every group of Cavia porcellus and be coated with respectively externally applied liniment 0.2 of the present invention, 0.4 and 0.8ml, contain respectively crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, put to death animal after experiment finishes and carry out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity activity, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, experiment is respectively organized the heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine for external application long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine for external application experiment safety of the present invention.

The vaginal mucomembranous irritant test report

1, experiment purpose: detect external preparation of the present invention to stimulation and the intensity of laboratory animal vaginal mucosa

2, materials and methods: tested material: title: liniment of the present invention; Laboratory animal: one grade of large ear white race rabbit, 4, female, body weight 2.1-2.3kg; Provided by biology department of Shandong University Experimental Animal Center;

3. test method:

The laboratory animal quarantine was selected 18 above-mentioned healthy rabbits after 3 days, was divided at random three groups, every group each 6, was respectively: blank, excipient contrast, tested material group (by using 5 times of concentration of liquid).Use respectively suitably big or small sterilization cotton sliver to soak with sterile saline and tested material and place excipient matched group and the intravaginal of tested material treated animal, contact 6 hours with vaginal mucosa, put to death animal after 24 hours.Take out local vagina tissue, observe the pathological changes situation.

4, result of the test:

Judge that according to " disinfection technology standard " (1999) medial vagina mucomembranous irritant test evaluation criterion liniment of the present invention has no stimulation to the rat vagina mucosa.

Other test result: under 20-21 ℃ of water bath condition, show through three repeated trials results, liniment 1.50% solution effects 20min of the present invention, be that 99.90%, 3.00% solution effects 10min killing rate is 99.94% to Candida albicans (ATCC10231) killing rate, 1.5% solution effects 15min is 99.94% to escherichia coli (8099), staphylococcus aureus (ATCC6538) killing rate.

The external used medicine pharmacodynamic experiment

Its impact on the healing of rat refractory wound surface of this laboratory observation.

1 materials and methods

1.1 animal: 40 of cleaning level SD rats, male, weight 200-250g, average (220.32 ± 10.10) g (being provided by biology department of Shandong University breeding center).

1.2 medicine: vaseline, necrosis removing and granulation promoting plaster, externally used paste of the present invention.

1.3 reagent and instrument: ketaject injection (every 011g/2mL, Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, lot number: KH051001); Hydrocortisone sodium succinate (every 50mg/2mL, the Tianjin Biochemical Pharmaceutical Factory produces, lot number: 20010419,20060104); (800,000 U/ prop up benzylpenicillin sodium for injection, and Huabei Pharmaceutic Co., Ltd produces, lot number: Y0511222).Electrocardiograph paper (specification 50mm * 30m, Shanghai three or five paper plant's company limiteies are produced).

1.4 modeling method: the full thickness dermal method is made the animal body surface Ulcer Models.Rat is divided into 5 groups at random: general wound surface group, model control group, vaseline group, necrosis removing and granulation promoting plaster group, unguentum group of the present invention, 8 every group.After rats by intraperitoneal injection ketalar (100mg/kg body weight) anesthesia, molding bay (lumbar vertebra hits exactly on the upper side) is shaved hair, with diameter 2cm plastic bottle closure at molding bay labelling modeling area, benzalkonium bromide tincture cotton balls skin degerming, cut off subcutaneous tissue to muscular fasciae along mark line, hemostasis, antiseptic gauze dressing covers wound, forms the open wound model of rat full thickness dermal (general wound surface).Except general wound surface group, remaining 4 groups of intramuscular injection hydrocortisone sodium succinates (8mg/100g body weight) at once after modeling, make the refractory wound surface model, injected continuously 5 days.Operation rose the same day, every group of equal intramuscular injection penicillin sodium salt (4000U/ is only), for three days on end, in case infect.

1.5 medication

Each organizes in modeling and begins to change dressings next day, and every day 1 time, it is front all with 1/5000 nitrofural clean wound to change dressings, and general wound surface group and model control group all cover with the normal saline gauze; All the other each groups are used respectively vaseline, externally used paste of the present invention, and necrosis removing and granulation promoting plaster spreads on wound surface, and the external sterile gauze covers, and medical proof fabric is fixed, and changes dressings until all wound surface all heal.

1.6 observation index

1.6.1 Wound healing rate: after modeling the 5th, 7,10 day, use the hyaline membrane flap coverage, mark stroke film covers hyaline membrane and calculates the wound surface area on the electrocardiograph paper.Calculate Wound healing rate by following formula: healing rate=(original wound surface area-the wound surface area does not heal)/original wound surface area * 100%.

1.6.2 wound healing time: record plays the complete epithelization required time of wound surface from topical agent.

1.7 statistical method

Adopt SPSS 11.0 softwares to carry out data analysis.Continuous data represents with mean ± standard deviation, carries out relatively group difference of a plurality of sample one factor analysis of variance.

2 results

2.1 the impact on Wound healing rate

The model control group Wound healing rate all was lower than general wound surface group (P＜0.05) in the 5th day, the 7th day, the 10th day, showed the modeling success.The 5th day, each intervention group Wound healing rate was compared no significant difference (P〉0.05) with model control group; The 7th day, vaseline group, necrosis removing and granulation promoting plaster group healing rate all were higher than model control group (P＜0.05); The 10th day, unguentum group healing rate of the present invention was apparently higher than vaseline group, necrosis removing and granulation promoting plaster group (P＜0.01).See Table 1.

Table 1 is respectively organized the different time points Wound healing rate relatively

Compare ， ﹡ P＜0.05 with general wound surface group; Compare △ P＜0.05, △ △ P＜0.01 with model control group.

2.2 the impact on wound healing time

Model control group wound healing time compared with normal wound surface group obviously prolongs (P＜0.01); Compare with model control group, powder group healing time of the present invention shortens (P＜0.01).See Table 2.

Table 2 is respectively formed the face healing time relatively

Compare ， ﹡ ﹡ P＜0.01 with general wound surface group; Compare △ △ P＜0.01 with model control group.

Clinical pharmacodynamics:

Diabetic foot (DF) is one of modal complication of diabetes (DM), is the main cause that causes diabetics to disable, cause death, and its pathogenesis is complicated, and the conventional therapy effect is relatively poor.A year JIUYUE employing Chinese medicine SHENGJISAN external application cooperates conventional western medical treatment DF 100 examples from March, 2006 to 2010 for we, and successful is reported as follows.

1 data and method

1.1 clinical data

1.1.1 all patients of diagnostic criteria all adopt the new diagnostic criteria of WHO diabetes in 1999, are diagnosed as type 2 diabetes mellitus and meet typing and the grade scale of diabetic foot.

1.1.2. physical data is selected my institute's diabetic foot (DF) ulcer 100 examples that year JIUYUE is accepted for medical treatment in March, 2006 to 2010, adopting at random, counter point is divided into treatment group and each 50 example of matched group.Treatment group 50 examples wherein, male's 28 examples, women's 22 examples; 47 ~ 76 years old age, average (51.23 ± 4.37) year; DF presses the Wagner classification: I level (shallow table ulcer) 10 examples, II level (deep ulcer but form and bone is got involved without abscess) 22 examples, II I level (deep ulcer such as cellulitis or abscess are formed with bone and get involved) 15 examples, IV level (local gangrene) 3 examples; Diabetic duration 4～35 years, average (8.69 ± 2.03) year; The diabetic foot course of disease 1 thoughtful 10 months, average (2.21 ± 0.39) individual month; Fasting glucose when being admitted to hospital (I1.58 ± 2.16) mmol/L.Matched group 50 examples, male's 27 examples, women's 23 examples; 43 ~ 75 years old age, average (51.97 ± 3.65) year; DF classification: I level 13 examples, II level 21 examples, III level (deep ulcer such as cellulitis or abscess are formed with bone and get involved) 14 examples, IV level (local gangrene) 2 examples; Diabetic duration 3～36 years, average (8.73 ± 1.98) year; The diabetic foot course of disease 1 thoughtful 11 months, average. (2.05 ± 0.35) month: fasting glucose when being admitted to hospital (11.60 ± 2.23) mmol/L.Learn by statistics processing and show, ask sex, age, the course of disease and state of an illness weight distribution situation relatively for two groups, and no significant difference (corpse〉0.05), have comparability.

1.2 Therapeutic Method

1.2.1 two groups of cases of Experience of Combined Treatment of Internal Medicine are identical.1. all control blood glucose in desirable level with oral antidiabetic drug or insulin; 2. select effective antibiotic infection control according to secretions antibacterial culturing and drug sensitive test; 3. improve the treatment of microcirculation and blood vessel dilating; 4. reasonable diet is controlled body weight; 5. appropriate exercise is advised in health education, notes the self health care of foot.

1.2.2 planing surface is processed two groups of cases and is all selected wound excision.Use first An Er iodine sterilization ulcer surrounding skin, wound surface has pus or the more person of secretions, cleans with 3% hydrogen peroxide, washes with the normal saline eddy current type, and cleans wound surface and remove slough with 0.1% hibitane cotton balls.Alternately irrigate with 3% hydrogen peroxide+normal saline+metronidazole at last, wash down wound surface with normal saline at last, and be stained with dried with sterile gauze.

1.2.3 the external application for curing treatment group gives the SHENGJISAN treatment on conventional General Medicine treatment and debridement basis.Ingredients: Fructus Psoraleae 18g, Herba Portulacae 22g, Radix Clematidis 20g, Radix Notoginseng 21g, Olibanum 18g, Myrrha 16g, Radix Et Rhizoma Rhei 19g, Cortex Phellodendri 17g, Calamina 20g, Cortex Dictamni 18g, Radix Sanguisorbae preparata 18g, Flos Carthami 20g, Fructus Kochiae 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 22g, Rhizoma Drynariae 19g, Radix Angelicae Sinensis 22g, Pheretima 18g, Plumbum preparatium 21g.Medicine-feeding is ground into powder, for subsequent use behind the mix homogeneously.Usage: the skin ulcer face cleans with 3% hydrogen peroxide first, wipe out slough as far as possible, clean with normal saline again, periphery skin 75% alcohol disinfecting, then the present invention is dispersed on the skin ulcer face equably, is advisable to cover and to surpass whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time.Treating 20 days is 1 course for the treatment of.

Matched group is in conventional General Medicine treatment and the gentamycin soak of debridement basis.Method: gentamycin 240,000 u are diluted in the 50ml normal saline.Spread on ulcer surface after sterile gauze soaked, 2～3 layers of sterile gauze of enclosing cover are fixed with Breathable adhesive tape.Change dressings 1 day 1 time.Treating 20 days is 1 course for the treatment of.

1.3 observation index and method be the variation of ulcer surface 1., the character of secretions and color, and whether incrustation comes off; 2. do blood, urine, just three large routine and hepatic and renal function inspections before and after the treatment, observe and the record treatment during have but erythra, local pain, dizziness, the untoward reaction generation such as feel sick; 3. followed up a case by regular visits to 6 months after all treating end for two groups.

1.4 the statistical method measurement data is checked with T, the ranked data rank test, and all computings are all carried out in SPSS13.0 software.

2 results

2.1 efficacy assessment standard is cured: ulcer wound surface heals fully, 0 grade of Wagner classification; Take a turn for the better: ulcer wound surface dwindles, and secretions reduces, and clinical Wagner classification takes a turn for the better 1 more than the rank; Invalid: ulcer wound surface is without dwindling, and secretions is without minimizing, and clinical scale is without taking a turn for the better or worsening.

2.2 two groups of comprehensive therapeutic effects relatively see Table 1.Relatively, observation group obviously is better than matched group, has statistical significance (p＜0.05) on cure rate and the total effective rate.

Table 3 liang group comprehensive therapeutic effect is [example (%)] relatively

Group	The example number	Cure	Take a turn for the better	Invalid	Total effectively %
						Treatment group	50	42（84）﹡	5(10)	3(6)	94%﹡
Matched group	50	34（68）	6(12)	10(20)	80%

Annotate: compare ， ﹡ p＜0.05 with matched group

2.3 the variation of the ulcer gross area relatively sees Table 2 before and after two groups of treatments.1. before two groups of treatments the ulcer gross areas relatively, difference there are no significant meaning (p〉0.05) has comparability; 2. two groups after treatment the ulcer gross area all be improved, and the treatment before and after difference have statistical significance (P＜0.05); 3. compare between the group, ulcer gross area comparison treatment group obviously is better than matched group after the treatment, and difference has statistical significance (p＜0.05); 4. two groups for the treatment of front and back differences compare, and the ulcer gross area improves the situation treatment group and obviously is better than matched group (P＜0.05).

Table 4 liang group ulcer gross area before and after treatment changes relatively (cm ²± S)

Annotate: relatively front with treatment, △ P＜0.05; Compare ， ﹡ p＜0.05 with matched group

2.4 two groups of healings relatively see Table 3.Ask that through rank test relatively treatment group obviously is better than matched group (p＜0.05) when healing.

Table 5 liang group healing relatively

Group	The example number	30d	30-60d	60-90d	90-150d
						Matched group	50	15	22	10	3
Treatment group	50	7	15	18	10

Annotate: compare P＜0.05 with matched group

2.5 untoward reaction observe two groups before and after treatment, have a blood test respectively, urinate, just three large routine and hepatic and renal functions, be showed no obvious toxicity.Two groups of patients are all without special discomfort in the therapeutic process.

3 discuss

Diabetic foot is one of serious complication of diabetes, is that diabetics causes death, the major reason that disables, and mainly take acral pain infection, ulcer, gangrene as main, biped is more serious in clinical manifestation.Footbath with traditional Chinese medicines obtains curative effect by the dual function of heat, medicine.The heat energy flesh muscle that relaxes, loose space between skin and muscles, promoting blood circulation to remove obstruction in the collateral, medicine is under the effect of heat energy, directly absorb by skin hole, acupuncture points on the human body etc. and to enter the blood network, defeated cloth whole body and bring into play drug action, but blood circulation promoting, blood vessel dilating improves surrounding tissue nutrition, excitating organism self-regulation function.

According to patient's disease, select corresponding prescription, great majority are activating blood and removing stasis drug, these medicines can be expanded lower limb vascular, suppress platelet aggregation, reduce blood viscosity, improve lower limb blood circulation, and diabetes are had obvious curative effect.But should note: (1) should suitably be strengthened this disease dosage; (2) avoid damaging healthy energy, be equipped with qi-invigorating, blood-nourishing medicinal; (3) to note monitoring coagulation function and hematoblastic variation in the medication.The treatment key is benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting comes off slough as early as possible, reaches tissue repair; The medicines such as oral blood sugar lowering, blood pressure lowering, blood fat reducing are effectively controlled blood glucose, regulate blood viscosity, are reduced blood pressure on the other hand; To prevent simultaneously foot to infect the enhancing human body immunity function.Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure.Oral medicinal herb and external application can improve the ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the purpose of ulcer surface wound healing.

To share removing dampness antipruritic for Plumbum preparatium and Calamina in the side, promoting tissue regeneration and ulcer healing, and it is anticorrosion to detoxify, and the Calamina external can be protected inflammation or damaged surface, absorbs secretions, avoids a large amount of protein to lose, and promotes incrustation; Olibanum, Myrrha share promoting blood circulation and stopping pain, detumescence and promoting granulation, and existing pharmacological research shows that two medicines all have stronger antibacterial bacteriostatic, anti-inflammatory analgesic action; The Radix Angelicae Sinensis qi-supplementing, blood-engendering, promoting pus discharge and tissue regeneration strengthening; The Flos Carthami benefiting blood and regulating blood circulation, eliminating stasis to stop pain; Radix Et Rhizoma Rhei, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication; But the Pseudobulbus Bletillae (Rhizoma Bletillae) and Herba Portulacae be eliminating fire and detoxication both, but removing dampness sore again, the protection wound surface.All medicines share, and play altogether promoting blood circulation and detoxication, the merit of expelling pus and promoting granulation.

This clinical observation shows that one aspect of the present invention promotes the growth of local blood circulation and granulation tissue; Protect on the other hand wound surface, avoid being subject to frictional impact, can also be isolated from the outside, reduce the generation that antibacterial infects, thereby can greatly improve the cure rate of DF, obviously shorten the ulcer surface healing time.And during treating, do not find obvious adverse reaction, so be used for clinical safety, effective, be worth into a popularization.

Claims

1. Chinese medicine for outer use for the treatment of diabetic foot, it is characterized in that the ratio of weight and number of various crude drug is in the described external preparation: 10～30 parts of Fructus Psoraleaes, 10～30 parts of Herba Portulacaes, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of Calaminas, 10～30 parts of Cortex Dictamnis, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of the Fructus Kochiae, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Pheretimas, 10～30 parts of Plumbum preparatiums.

2. the Chinese medicine for outer use of described treatment diabetic foot according to claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the described external preparation: 10～20 parts of Fructus Psoraleaes, 10～20 parts of Herba Portulacaes, 10～20 parts of Radix Clematidis, 10～20 parts of Radix Notoginseng, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Cortex Phellodendris, 10～20 parts of Calaminas, 10～15 parts of Cortex Dictamnis, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts on Flos Carthami, 10～15 parts of the Fructus Kochiae, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pheretimas, 10～15 parts of Plumbum preparatiums.

3. the Chinese medicine for outer use of described treatment diabetic foot according to claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the described external preparation: 10～15 parts of Fructus Psoraleaes, 10～15 parts of Herba Portulacaes, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～15 parts of Calaminas, 10～20 parts of Cortex Dictamnis, 10～20 parts of Radix Sanguisorbae preparatas, 10～20 parts on Flos Carthami, 10～20 parts of the Fructus Kochiae, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pheretimas, 10～20 parts of Plumbum preparatiums.

4. the Chinese medicine for outer use of described treatment diabetic foot is characterized in that according to claim 1～3, and the dosage form of described Chinese medicine for outer use is: unguentum, spray, liniment, loose powder agent, smear ointment, tincture or gauze agent.

5. one kind such as the preparation method of the Chinese medicine for outer use for the treatment of diabetic foot as described in each in the claim 1～3, it is characterized in that the dosage form of described medicine is unguentum, and its preparation method comprises:

6. the preparation method of the Chinese medicine for outer use of described treatment diabetic foot according to claim 5 is characterized in that, among the described step a, adds except Plumbum preparatium and Calamina by the crude drug of described ratio of weight and number in the Oleum Sesami of 5-10 times of weight portion and soaks 7-10 days; With the soaked crude drug heating extraction of Oleum Sesami, big fire is boiled, and firepower reduces after the Oleum Sesami boiling, endures to the crude drug appearance to be dark brown, and inner coke yellow is pulled medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl.

7. the preparation method of the Chinese medicine for outer use of described treatment diabetic foot according to claim 5 is characterized in that, among the described step b, the Plumbum preparatium is fried to dark yellow, removes moisture, crosses 100 orders-120 mesh sieve and removes impurity; The Plumbum preparatium is added in the good medicine oil of refining, constantly stir, become the thick paste of black.

8. the preparation method of the Chinese medicine for outer use of described treatment diabetic foot according to claim 5 is characterized in that, among the described step c, in impouring cold water after the cooling of black thick paste, soaks 5-10 days, changes water every day once, and releasing fire-toxin mixes the Calamina of pulverizing.

9. one kind such as the preparation method of the Chinese medicine for outer use for the treatment of diabetic foot as described in each in the claim 1～3, it is characterized in that, the dosage form of described medicine is liniment, preparation method comprises: described crude drug is added soak with ethanol 1-2 hour except Plumbum preparatium and Calamina, heating was boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds ethanol and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Merge three times extracting solution, be concentrated into relative density and be 1.08 concentrated solution; Filter, left standstill 24 hours, after remove supernatant, get concentrated medicament; Plumbum preparatium and Calamina are broken into fine powder, drop in the concentrated medicament, mediation 70%-80% vaseline, tinning.

10. one kind such as the preparation method of the Chinese medicine for outer use for the treatment of diabetic foot as described in each in the claim 1～3, it is characterized in that, the dosage form of described medicine is powder, preparation method comprises: according to the ratio of weight and number of described crude drug with Radix Clematidis, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction stand for standby use; During extraction, use first the soak with ethanol of 70%-80%, rear 60～80 ℃ of heating extraction 2 times, each 1 hour; 10 times of amounts of the gross weight of used ethanol and Radix Clematidis, Radix Notoginseng and three kinds of medical materials of the Pseudobulbus Bletillae (Rhizoma Bletillae); The concentrated ethanol extract of heating, 1.06 concentrated solution when being concentrated into relative density and being 20 ℃.All the other described crude drug are mixed by proportioning except Plumbum preparatium and Calamina, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flooded 10～15 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and are then mixed with aforementioned concentrated solution; Described mixed liquid heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, mix Plumbum preparatium and the Calamina of pulverizing and make powder.