CN107137471A - A kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application - Google Patents

A kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application Download PDF

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CN107137471A
CN107137471A CN201710491429.9A CN201710491429A CN107137471A CN 107137471 A CN107137471 A CN 107137471A CN 201710491429 A CN201710491429 A CN 201710491429A CN 107137471 A CN107137471 A CN 107137471A
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root
chinese medicine
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胡育礼
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Abstract

The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application.Traditional Chinese medicine used as analgesic composition of the present invention, is made up of the raw material of following weight part ratio：0.5 1.5 parts of 3.5 10.5 parts of ford dutchmanspipe root or herb, 39 parts of climbing fig, 39 parts of gecko, 39 parts of laciniate blumea herb, 39 parts of Chinese hydrangeavine root-bark, 39 parts of safflower, 39 parts of frankincense, 39 parts of myrrh, 39 parts of teasel root, 39 parts of native copper, 39 parts of lamiophlomis rotata, 2.5 7.5 parts of paniculate swallowwort, 2.5 7.5 parts of the root of Chinese clematis, 26 parts of notopterygium root, 26 parts of levisticum, 26 parts of Radix Angelicae Sinensis, 26 parts of turpentine, 13 parts of the root of Dahurain angelica, 13 parts of borneol and menthol.The present invention is applied to wind-cold-dampness arthralgia, beat the stasis of blood swell etc. caused by various pain, and carbuncle swells, have a dizzy spell, in the medicine of clouded in mind or snake bite and insect sting, present invention also offers the preparation method of the Chinese medicine composition.

Description

A kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application
【Technical field】
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Traditional Chinese medicine used as analgesic composition and preparation method thereof and should With.
【Background technology】
Card is at first reaction of the various diseases in human body, such as cardio-cerebral diseases, vascular diseases, disease in the liver and gallbladder, wound, god Through systemic disease, tumour etc., it may be said that be a kind of most common biological phenomena bitterly.Why we may feel that painIn Doctor often says " general rules do not hurt, pain is not unreasonable ".Qi and blood essence body fluid along respective channels and collaterals sering normally operation to whole body and it is fluent, The foster vital organs of the human body are moistened, make one to feel energetic, it is energetic, it is not felt by pain.And if these small pipelines of channels and collaterals are a certain Place is stifled by the stasis of blood, and stagnation of QI-blood, it is impossible to circulate influences whether the normal operation of whole machine at once.Once the stasis of blood is blocked up, it is impossible to dredged in time Logical, in the course of time, qi depression to blood stasis is formed accumulates poison in vivo, will make one to produce pain.《Plain Questions is lifted pain and discussed》Say：" channels and collaterals stream Row is more than, and ring week, cold air entered through then checking late endlessly, tears and it is not all right, visitor is in then blood is few outside arteries and veins, visitor's then flow of QI being obstructed in arteries and veins, therefore soldier But pain.”
Wind-cold-dampness arthralgia, Chinese medical disease name is the gas exopathogen of wind, cold, wet three invasion and attack channels and collaterals, and qi and blood impatency is not smooth caused, is Row (wind) numbness, pain (cold) numbness, work (wet) numbness are collectively referred to as, and are common to cause one of cause of disease of pain.Because wet three gas of chill is miscellaneous extremely, cause Stagnation of QI-blood, card is shown in body weight and pain, spasm of limbs, very then walks to note pain, or numb in every limb etc..It is exopathogen invasion and attack channels and collaterals, qi and blood Impatency is not smooth, causes joint, limbs etc. the symptoms, entitled bi Zheng such as acid, pain, fiber crops, weight and joint stuffiness occur.Wind, cold, wet disease Heresy stays note muscle, muscles and bones, joint, causes channels and collaterals to be jammed, QI-blood circulation is not smooth, and limbs spasm of muscles and vessels, mistake are supported as the basic of this disease The interpretation of the cause, onset and process of an illness.But chill diseases caused by dampness heresy emphasizes particularly on different fields, ailment said due to cold or exposure notably, flee by disease and evil, and lesion migration is indefinite to suffer from；Cold-evil notably, stern sun Gas, sharp ache；Damp evil notably, sticks together solidification, and lesion calmness is not moved.With the passing of time numbness disease is not cured, and qi-blood-body fluid runs not smooth disease Become day very, blood-vessel obstructive, body fluid cohesion, phlegm and blood stasis, impatency channels and collaterals go deep into bone joint, the dermal ecchymosis, arthroncus deformity occur Deng disease, internal organs are evend penetrate into, the syndrome for internal organs numbness occur.Clinical manifestation is that joint pain or part muscle acid weight are numb, delay With the passing of time limbs arrested anxious can be caused, very then arthrocele.Caused by wind, cold and wetness evils described in the present invention includes the rheumatic described in modern medicine Arthritis, rheumatoid arthritis, sciatica, ankylosing spondylitis etc..
Key, is often referred to head or head, key position is fallen ill, and usually phlegm is turbid to be blinded, or obstruction of the orifices by blood stasis, often shows as refreshing knowledge Unclear, the disturbance of consciousness, tongue fur is dark violet, thready and hesitant pulse.I.e. when human body by extraneous perverse trend is caused key stasis blocking, then it can have a dizzy spell, very To clouded in mind, need to have one's ideas straightened out in the rules for the treatment of.
City fast pace, the living environment of high pressure, made the pain patients such as wind-cold-dampness arthralgia and were had a dizzy spell in recent years Puzzlement crowd's incidence of disease present ascendant trend, fall ill Swarm intention rejuvenation.Due to the wind-cold-dampness arthralgia illness course of disease long, at present It is difficult to effect a radical cure, whenever morbidity is just severely impacted patient's normal life, pain makes patient endure torment to the fullest extent.
【The content of the invention】
The goal of the invention of the present invention is：In view of the above-mentioned problems, providing a kind of Traditional Chinese medicine used as analgesic composition, dissipated with middle benefit gas Cold, evacuate pathogenic wind dehumidifying is stimulated the circulation of the blood and cause the muscles and joints to relax, and the Eradicates stasis of bloods of invigorating blood circulation, swelling and pain relieving, relieving convulsion effect of having one's ideas straightened out applied to wind-cold-dampness arthralgia, is beaten the stasis of blood swell The various pain Deng caused by, and carbuncle swells, have a dizzy spell, in the medicine of clouded in mind or snake bite and insect sting, present invention also offers this The preparation method of Chinese medicine composition.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：3.5-10.5 parts of ford dutchmanspipe root or herb, climbing fig 3-9 Part, 3-9 parts of gecko, 3-9 parts of laciniate blumea herb, 3-9 parts of Chinese hydrangeavine root-bark, 3-9 parts of safflower, 3-9 parts of frankincense, 3-9 parts of myrrh, 3-9 parts of teasel root, 3-9 parts of native copper, 3-9 parts of lamiophlomis rotata, 2.5-7.5 parts of paniculate swallowwort, 2.5-7.5 parts of the root of Chinese clematis, 2-6 parts of notopterygium root, 2-6 parts of levisticum, 0.5-1.5 parts of 2-6 parts of Radix Angelicae Sinensis, 2-6 parts of turpentine, 1-3 parts of the root of Dahurain angelica, 1-3 parts of borneol and menthol.
Optimization, it is made up of the raw material of following weight part ratio：5-9 parts of ford dutchmanspipe root or herb, 4.8-7.2 parts of climbing fig, gecko 4.8-7.2 Part, 4.8-7.2 parts of laciniate blumea herb, 4.8-7.2 parts of Chinese hydrangeavine root-bark, 4.8-7.2 parts of safflower, 4.8-7.2 parts of frankincense, 4.8-7.2 parts of myrrh, 4.8-7.2 parts of teasel root, 4.8-7.2 parts of native copper, 4.8-7.2 parts of lamiophlomis rotata, 4-6 parts of paniculate swallowwort, 4-6 parts of the root of Chinese clematis, notopterygium root 3.2-4.8 parts, 3.2-4.8 parts of levisticum, 3.2-4.8 parts of Radix Angelicae Sinensis, 3.2-4.8 parts of turpentine, 1.6-2.4 parts of the root of Dahurain angelica, borneol 1.6-2.4 0.8-1.2 parts of part and menthol.
More optimize, be made up of the raw material of following weight part ratio：7 parts of ford dutchmanspipe root or herb, 6 parts of climbing fig, 6 parts of gecko, laciniate blumea herb 6 Part, 6 parts of Chinese hydrangeavine root-bark, 6 parts of safflower, 6 parts of frankincense, 6 parts of myrrh, 6 parts of teasel root, 6 parts of native copper, 6 parts of lamiophlomis rotata, 5 parts of paniculate swallowwort, prestige 1 part of 5 parts of medicine xiaolingxian, 4 parts of notopterygium root, 4 parts of levisticum, 4 parts of Radix Angelicae Sinensis, 4 parts of turpentine, 2 parts of the root of Dahurain angelica, 2 parts of borneol and menthol.
Re-optimization, the native copper is processed product pyritum ignited, and Radix Angelicae Sinensis is selected from Radix Angelicae Sinensis tail.
A kind of preparation method of above-mentioned Traditional Chinese medicine used as analgesic composition, is mainly made up of following steps：By weight, first will be upper State all raw materials to crush respectively, be well mixed, obtain mixed-powder；Then take and mixed described in the solvent soaking containing certain alcohol concentration Powder is closed, filtering finally collects filtrate, adjusts filtrate alcohol concentration, produce Traditional Chinese medicine used as analgesic composition.
Optimization, one or more of the solvent in ethanol, white wine, rice wine and yellow rice wine, the alcohol of the solvent Concentration is 55-75wt%；The time of the immersion is no less than 2 hours.
More optimize, the consumption of the solvent is that 6-15 times of the mixed-powder weight is measured by weight.
Further optimize, adjustment filtrate alcohol concentration is 30-40wt%.Alcohol concentration is high, volatilizees too fast, stimulates skin Skin；As, if alcohol concentration is higher than 40wt%, as the solution carrier of this Chinese medicine composition, worked in the present invention with medicine one In sense of discomfort after human body, can be aggravated, produce certain conflict medication at heart, affect the treatment.If alcohol concentration is less than 30wt%, use Drug volatilization speed slows down after medicine, and liquid is easily flowed down, it is difficult in the color film of agents area formation protection, affect the treatment；Alcohol concentration Less than 30wt%, on the other hand, the stability of this combination of traditional Chinese medicine thing declines, and the holding phase shortens.By multiple stability test With 20 human body patient medication comfort level experiments, it is believed that adjustment filtrate alcohol concentration is optimal for 30-40wt%.
Further optimize, Traditional Chinese medicine used as analgesic composition is further made form of Chinese drug, the form of Chinese drug be selected from tincture, One kind in vina, spray, film, pill, paste, liniment and tablet.During above-mentioned preparation of preparation, receive pharmacy Go up the pharmacies such as acceptable conventional pharmaceutical adjuvants, including diluent, adhesive, wetting agent, disintegrant, lubricant, glidant Upper acceptable pharmaceutic adjuvant.
A kind of preparation method of above-mentioned Traditional Chinese medicine used as analgesic composition, is mainly made up of following steps：By weight, Chinese medicine is taken Composition components, cut into slices or crush respectively, are well mixed, then take mixed powder described in the solvent soaking containing certain alcohol concentration Filtrate is finally collected in end, filtering, is adjusted filtrate alcohol concentration, is produced Traditional Chinese medicine used as analgesic composition.
Further optimize again, applied in the medicine for alleviating or treating pain is prepared, especially in alleviation or medical needle To wind-cold-dampness arthralgia, beat the stasis of blood swell caused by various pain medicine in apply.
Further optimize again, in any or several drugses purposes of clouded in mind, skin measles toxicity and snake bite and insect sting Using.
The medicine main function used in the present invention (is selected from as follows《Dictionary of medicinal plant》)：
1st, ford dutchmanspipe root or herb：It is warm-natured.Function：Dispelling wind and eliminating dampness, subdhing swelling and detoxicating.Cure mainly：Heart and stomach pain, treating rheumatic ostealgia, traumatic injury, Child convulsion, venomous snake bite.
2nd, climbing fig：Also known as Boston ivy, it is mild-natured.Function：Dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, removing toxicity for detumescence.Cure mainly：Arthralgia pain due to rheumatism, Sciatica, amenorrhoea, postpartum blood stasis stomachache, dysmenorrhoea, ulcerative carbuncle pyogenic infections, traumatic injury.
3rd, gecko：It is cold in nature.Function：Dispelling wind and relieving convulsion, detoxicating and resolving a mass.Cure mainly：Apoplexy frightened spare time, severe and wadering arthralgia pain, lockjaw, carbuncle Sore, scrofula, pestilential wind, wind tinea is dysphagic.
4th, laciniate blumea herb：Also known as winged mountain tiger, slightly warm in nature.Function：Dispelling wind and removing obstruction in the meridians, removing toxic substances.Cure mainly：Head wind headache, wind-cold-dampness arthralgia, Joint pain, traumatic injury, carbuncle swells boil, eczema, snakebite.
5th, Chinese hydrangeavine root-bark：Also known as black tiger, it is warm-natured.Function：Scattered stasis, removes obstruction in channels to relieve pain.Stomachache is cured mainly, arthralgia pain due to rheumatism falls Beat damage, fracture, dysmenorrhoea, postpartum blood stasis stomachache, hernia pain.
6th, safflower：It is warm-natured.Function：Invigorate blood circulation, stasis-dispelling and pain-killing.Cure mainly blood stasis, Amenorrhea, dysmenorrhoea, postpartum stasis stomachache, chest The pained , lumps in the chest and abdomen of numbness, traumatic injury, arthralgia, hemiplegia, macula.
7th, frankincense：It is warm-natured.Function：Blood-activating and qi-promoting, relieves pain myogenic.Cure mainly trusted subordinate's pain, amenorrhoea, dysmenorrhoea, the stagnant abdomen of the postpartum stasis of blood Bitterly, bruise stasis caused pain, swollen ulcer drug, unhealing ulcer, ruptured abscess resistant to healing.
8th, myrrh：It is mild-natured.Function：Dissolving stasis, detumescence, analgesic therapy.Cure mainly chest and abdomen pain, dysmenorrhoea, Amenorrhea , Disorder lumps in the abdomen, treating swelling and pain by traumatic injury, carbuncle Swollen sore, red eye, swell pain.
9th, teasel root：Slightly warm in nature.Function：Blood vessels, only uterine bleeding are adjusted in filling liver kidney, strengthening the bones and muscles.Cure mainly aching pain in waist and back, podomere Impotence numbness, Fall and flutter wound, damage muscle folding bone, ulcer sore swells.
10th, native copper：It is mild-natured.Function：Blood stasis removing analgesic, reunion of fractured tendons and bones.Traumatic injury is cured mainly, breaking of muscle and tendon is fractured, and the stasis of blood is stagnant to swell and ache. Pyritum ignited, is the processed product of native copper, concocting method was by version in 2015《Chinese Pharmacopoeia》Relevant criterion is carried out under.
11st, lamiophlomis rotata：It is mild-natured.Function：It is promoting blood circulation and removing blood stasis, swelling and pain relieving.Cure mainly bruise, arthralgia and myalgia, painful swelling of joints, pain Through uterine bleeding.
12nd, notopterygium root：It is warm-natured.Function：Exterior cold is dissipated, evacuate pathogenic wind is wet, sharp joint, analgesic.Cure mainly and catch cold, lossless, wind of having a headache Cold-dampness numbness, geomantic omen edema, sore swollen toxin.
13rd, levisticum：It is mild-natured.Function：Expelling wind and eliminating dampness, eliminating cold to stop pain.Cure mainly wind-cold-dampness arthralgia, lumbocrural pain, dentalgia of having a headache.
14th, the root of Dahurain angelica：It is warm-natured.Function：Dispelling wind and eliminating dampness, sensible analgesic, detumescence and apocenosis.Cure mainly cold headache, pain in the supra-orbital bone, tooth Bitterly, have a stuffy nose, nasosinusitis, wet victory chronic diarrhea, leukorrhea with reddish discharge, ulcer sores.
15th, paniculate swallowwort：It is warm-natured.Function：Dispelling wind and eliminating dampness, the promoting flow of qi and blood circulation is unsting antipruritic.Cure mainly arthralgia pain due to rheumatism, pain in the back, gastral cavity abdomen Pain, toothache, the pain of injury caused by falling and tumbling, eczema, nettle rash, venomous snake bite.
16th, turpentine：It is warm-natured.Function:Wind-dispelling, eliminating dampness, relaxing muscles and tendons is active, analgesic.Cure mainly wind-cold-dampness arthralgia, severe and wadering arthralgia pain, convulsion Contraction is anxious, and pin numbness impotence is soft, arthroncus of knee injuries from falls as well.
17th, the root of Chinese clematis：It is warm-natured.Function:Dispelling wind and eliminating dampness, removes obstruction in channels to relieve pain.Cure mainly arthralgia pain due to rheumatism, extremity numbness, spasm of muscles and vessels, Joint stuffiness, tinea pedis swells and ache.
18th, Radix Angelicae Sinensis tail：It is warm-natured.Function:《Herbal justice》' return body master to keep, mend intrinsic work(, return tail master to lead to, by the stasis of blood certainly Test ... '.Irregular menstruation is cured mainly, Amenorrhea, dysmenorrhoea , Disorder lumps in the abdomen knot gathers, Impotence numbness, numbness, injury from falling down.
19th, borneol：Cold nature.Function inducing resuscitation of having one's ideas straightened out, radiating analgesic, shade removing.Cure mainly apoplexy lockjaw, pyreticosis coma, Frightened epilepsy phlegm fan, deafness with qi stagnation, larynx numbness, carbuncle swells, hemorrhoid.
20th, menthol：It is cool in nature.Function dispelling wind, heat-clearing.Anemopyretic cold is cured mainly, is had a headache, hot eyes, abscess of throat, dentalgia, skin Skin itch.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
The present invention, according to occurring pain, is due to that passages through which vital energy circulates is obstructed more, and human body locally cannot normally moisten foster, not Rong Ze pains The traditional Chinese medical science is instructed, it has been investigated that patient causes QI-blood circulation to be obstructed because of damp evil invasion body of having a cold, dyshaemia cannot be timely Cure and produce pain, the course of disease is more long more touching refractory；Or some patientss body is once local by physical shock, causes the stasis of blood Swollen, occupy-place compressing cannot be mediated in time, caused passages through which vital energy circulates to be obstructed or stop and caused part to cannot get normal blood oxygen supply and produce pain Bitterly.The present invention is coordinated using 20 taste Chinese medicines altogether to be formed, jointly with good warming spleen and stomach for dispelling cold, and evacuate pathogenic wind dehumidifying is stimulated the circulation of the blood and cause the muscles and joints to relax, invigorated blood circulation The Eradicates stasis of bloods, swelling and pain relieving, relieving convulsion effect of having one's ideas straightened out can effectively dispel new and old wind-cold-dampness arthralgia in human body, fundamentally cure because of chill The stasis of blood caused by arthritis with fixed pain caused by dampness caused by various pain, traumatic injury swells, new and old pain has good efficacy；Wind-heat poison gas is caused simultaneously Skin measles toxicity, had a dizzy spell caused by head key is obstructed, clouded in mind, snake bite and insect sting etc. also have treat or aid in very well it is auxiliary Help effect.Chinese medicine composition of the present invention can be used for the exclusive use of above-mentioned illness or use cooperatively.
In effects embodiment, by the way that the present invention is prepared according to preparation method of the present invention, and on patient Tested, it is pain caused to wind-cold-dampness arthralgia, beat the stasis of blood swell caused by new and old pain, snake bite and insect sting, obnubilation, skin measles toxicity, Above patient is respectively provided with good curative effect；Carry out 5 days, (do not wrapped in the safety testing that daily medication is 4 times to 20 health workers Include pregnant and lying-in women and alcohol intolerance person), nobody has adverse reaction, Chinese medicine composition safety of the present invention.
Totally 20 taste medicine Chinese medicines are constituted Chinese medicine composition of the present invention, and its matching relationship is as follows：First, lead in the present composition City tiger, climbing fig, laciniate blumea herb, Chinese hydrangeavine root-bark, safflower, frankincense, myrrh, native copper, lamiophlomis rotata, teasel root, notopterygium root, the root of Dahurain angelica, paniculate swallowwort, pine Section, the root of Chinese clematis, Radix Angelicae Sinensis (Radix Angelicae Sinensis tail) are property of medicine warm nature, with the use of with good promoting blood circulation, promoting qi circulation and relieving pain effect, can be had Effect dispel human body internal cause wind-cold-dampness arthralgia retardance or hemostasis resistance caused by qi and blood fortune be obstructed, dyshaemia, so as to fundamentally control More because of the disease of the pain caused by wind-cold-dampness arthralgia retardance or hemostasis resistance.Levisticum, lamiophlomis rotata, myrrh can also promoting qi circulation and relieving pain, help evil poison to arrange Go out external.Secondly, in the present composition gecko, the root of Dahurain angelica, borneol and the taste Chinese medicine of menthol three use cooperatively with dispelling wind and heat from the body, Have one's ideas straightened out relieving convulsion effect, assist cold-evil and/or stasis blocking to excrete, blinded while can also treat because phlegm is turbid or obstruction of the orifices by blood stasis causes Have a dizzy spell, the illness such as obnubilation, with relieving convulsion effect of having one's ideas straightened out；Subcutaneous measles toxicity can also be dismissed, to skin nettle rash or mistake The disease treatment that quick, rash is itched can play good efficacy.3rd, ford dutchmanspipe root or herb, laciniate blumea herb, paniculate swallowwort are all snakebite in the present composition Key medicine, in the presence of we have dredging stasis blocking, the evil numbness of discharge very well, the addition of this three tastes snakebite key medicine can be treated effectively The wound of snakeworm, plus outwards mediated in wound with snakeworm and reach the purpose that the poison for suppressing snakeworm spreads.4th, we in containing Have the ethanol solution or wine of certain alcohol concentration as solvent, preferably white wine, in addition solvent have in itself sterilization, wind dispelling cold dispelling and Promoting blood circulation effect, helps the power of medicine row diverging, synergy heightens the effect of a treatment.Chinese medicine composition prescription compatibility of medicines structure of the present invention is careful to close Reason, synergy, therefore with effect it is good.
Present invention also offers the preparation method of the Chinese medicine composition, the preparation method has simple, easily controllable, repetition Property is good, it is adaptable to various dosage scale production and applications.
【Embodiment】
With reference to embodiment, the invention will be further described.
First, formulation Example
Embodiment 1
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：3.5 parts of ford dutchmanspipe root or herb, 3 parts of climbing fig, gecko 3 Part, 3 parts of laciniate blumea herb, 3 parts of Chinese hydrangeavine root-bark, 3 parts of safflower, 3 parts of frankincense, 3 parts of myrrh, 3 parts of teasel root, 3 parts of native copper, 3 parts of lamiophlomis rotata, Xu Long 2.5 parts of minister in ancient times, 2.5 parts of the root of Chinese clematis, 2 parts of notopterygium root, 2 parts of levisticum, 2 parts of Radix Angelicae Sinensis, 2 parts of turpentine, 1 part of the root of Dahurain angelica, 1 part of borneol and menthol 0.5 part.
Embodiment 2
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：10.5 parts of ford dutchmanspipe root or herb, 9 parts of climbing fig, gecko 9 parts, 9 parts of laciniate blumea herb, 9 parts of Chinese hydrangeavine root-bark, 9 parts of safflower, 9 parts of frankincense, 9 parts of myrrh, 9 parts of teasel root, 9 parts of native copper, 9 parts of lamiophlomis rotata, 7.5 parts of paniculate swallowwort, 7.5 parts of the root of Chinese clematis, 6 parts of notopterygium root, 6 parts of levisticum, 6 parts of Radix Angelicae Sinensis, 6 parts of turpentine, 3 parts of the root of Dahurain angelica, 3 parts of borneol and peppermint 1.5 parts of brain.
Embodiment 3
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：5.6 parts of ford dutchmanspipe root or herb, 4.8 parts of climbing fig, wall 4.8 parts of tiger, 4.8 parts of laciniate blumea herb, 4.8 parts of Chinese hydrangeavine root-bark, 4.8 parts of safflower, 4.8 parts of frankincense, 4.8 parts of myrrh, 4.8 parts of teasel root, nature 4.8 parts of copper, 4.8 parts of lamiophlomis rotata, 4 parts of paniculate swallowwort, 4 parts of the root of Chinese clematis, 3.2 parts of notopterygium root, 3.2 parts of levisticum, 3.2 parts of Radix Angelicae Sinensis, turpentine 3.2 Part, 1.6 parts of the root of Dahurain angelica, 1.6 parts of borneol and 0.8 part of menthol.
Wherein, native copper is processed product pyritum ignited, and Radix Angelicae Sinensis is selected from Radix Angelicae Sinensis tail.
Embodiment 4
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：8.4 parts of ford dutchmanspipe root or herb, 7.2 parts of climbing fig, wall 7.2 parts of tiger, 7.2 parts of laciniate blumea herb, 7.2 parts of Chinese hydrangeavine root-bark, 7.2 parts of safflower, 7.2 parts of frankincense, 7.2 parts of myrrh, 7.2 parts of teasel root, nature 7.2 parts of copper, 7.2 parts of lamiophlomis rotata, 6 parts of paniculate swallowwort, 6 parts of the root of Chinese clematis, 4.8 parts of notopterygium root, 4.8 parts of levisticum, 4.8 parts of Radix Angelicae Sinensis, turpentine 4.8 Part, 2.4 parts of the root of Dahurain angelica, 2.4 parts of borneol and 1.2 parts of menthol.
Wherein, native copper is processed product pyritum ignited, and Radix Angelicae Sinensis is selected from Radix Angelicae Sinensis tail.
Embodiment 5
A kind of Traditional Chinese medicine used as analgesic composition, is made up of the raw material of following weight part ratio：7 parts of ford dutchmanspipe root or herb, 6 parts of climbing fig, gecko 6 Part, 6 parts of laciniate blumea herb, 6 parts of Chinese hydrangeavine root-bark, 6 parts of safflower, 6 parts of frankincense, 6 parts of myrrh, 6 parts of teasel root, 6 parts of native copper, 6 parts of lamiophlomis rotata, Xu 1 part of long 5 parts of minister in ancient times, 5 parts of the root of Chinese clematis, 4 parts of notopterygium root, 4 parts of levisticum, 4 parts of Radix Angelicae Sinensis, 4 parts of turpentine, 2 parts of the root of Dahurain angelica, 2 parts of borneol and menthol.
Wherein, native copper is processed product pyritum ignited, and Radix Angelicae Sinensis is selected from Radix Angelicae Sinensis tail.
2nd, preparation method embodiment
Embodiment 6
A kind of preparation method of any one of embodiment 1-5 Traditional Chinese medicine used as analgesic compositions, is mainly made up of following steps：
By weight, first above-mentioned all raw materials are crushed respectively, is well mixed, obtains mixed-powder；Then take containing one Determine mixed-powder described in the solvent soaking of alcohol concentration, filtrate is finally collected using percolation, adjustment filtrate alcohol concentration is 30wt%, produces Traditional Chinese medicine used as analgesic composition.
Wherein, solvent is selected from ethanol, and the alcohol concentration of the solvent is 55wt%.The consumption of the solvent by weight, For 6 times of amounts of the mixed-powder weight.
Further, take Traditional Chinese medicine used as analgesic composition that form of Chinese drug is further made, the form of Chinese drug is selected from tincture.
Embodiment 7
A kind of preparation method of any one of embodiment 1-5 Traditional Chinese medicine used as analgesic compositions, is mainly made up of following steps：
By weight, first above-mentioned all raw materials are crushed respectively, is well mixed, obtains mixed-powder；Then take containing one Determine mixed-powder described in the solvent soaking of alcohol concentration, finally collect filtrate, adjustment filtrate alcohol concentration is 40wt%, is produced only Pain Chinese medicine composition.
Wherein, solvent is selected from white wine, and the alcohol concentration of the solvent is 75wt%.The consumption of the solvent by weight, For 15 times of amounts of the mixed-powder weight.
Further, take Traditional Chinese medicine used as analgesic composition that form of Chinese drug is further made, the form of Chinese drug is selected from vina.
Embodiment 8
A kind of preparation method of any one of embodiment 1-5 Traditional Chinese medicine used as analgesic compositions, is mainly made up of following steps：
By weight, first above-mentioned all raw materials are crushed respectively, is well mixed, obtains mixed-powder；Then take containing one Determine mixed-powder described in the solvent soaking of alcohol concentration, finally collect filtrate, adjustment filtrate alcohol concentration is 35wt%, is produced only Pain Chinese medicine composition.
Wherein, solvent is selected from the mixture of white wine and rice wine, and the alcohol concentration of the solvent is 60wt%.The solvent Consumption is 8 times of amounts of the mixed-powder weight by weight.
Further, take Traditional Chinese medicine used as analgesic composition that form of Chinese drug is further made, the form of Chinese drug is selected from spray.
Embodiment 9
A kind of preparation method of any one of embodiment 1-5 Traditional Chinese medicine used as analgesic compositions, is mainly made up of following steps：
By weight, first above-mentioned all raw materials are crushed respectively and crosses 60 mesh sieves, powder is well mixed, mixed powder is obtained End；Then mixed-powder described in the solvent soaking containing certain alcohol concentration is taken, 2 hours are soaked, is finally received using percolation Collect filtrate, adjustment filtrate alcohol concentration is 45wt%, produces Traditional Chinese medicine used as analgesic composition.
Wherein, solvent is selected from ethanol, and the alcohol concentration of the solvent is 55wt%.The consumption of the solvent by weight, For 12 times of amounts of the mixed-powder weight.
Further, take Traditional Chinese medicine used as analgesic composition that form of Chinese drug is further made, the form of Chinese drug is selected from liniment.
Embodiment 10
A kind of preparation method of any one of embodiment 1-5 Traditional Chinese medicine used as analgesic compositions, is mainly made up of following steps：
By weight, first above-mentioned all raw materials are crushed respectively and crosses 200 mesh sieves, powder is well mixed, must be mixed Powder；Then mixed-powder described in the solvent soaking containing certain alcohol concentration is taken, soaks 30 days, is finally collected using percolation Filtrate, adjustment filtrate alcohol concentration is 32wt%, produces Traditional Chinese medicine used as analgesic composition.
Wherein, solvent is selected from ethanol, and the alcohol concentration of the solvent is 65wt%.The consumption of the solvent by weight, For 12 times of amounts of the mixed-powder weight.
Further, take Traditional Chinese medicine used as analgesic composition that form of Chinese drug is further made, the form of Chinese drug is selected from Sprayable Tincture.It is appreciated that solvent is selected from yellow rice wine, or ethanol, rice wine, white wine and arbitrarily arranged in pairs or groups in the present invention, simply different solvents There is some difference for the effect of obtained extract, but can realize the purpose that the present invention comes out extracts active ingredients.
It is appreciated that form of Chinese drug of the present invention can also routinely pharmaceutical technology by the obtained Traditional Chinese medicine used as analgesic composition of the present invention Further it is made any in film, pill, paste, liniment and tablet.
3rd, Application Example
A kind of purposes of Traditional Chinese medicine used as analgesic composition described in utilization embodiment any one of 1-5, alleviates or treatment pain preparing Applied in the medicine of pain, especially alleviation or medical needle to wind-cold-dampness arthralgia, beat the stasis of blood swell caused by various pain medicine in should With.
The purposes of Traditional Chinese medicine used as analgesic composition described in a kind of utilization embodiment any one of 1-5, in clouded in mind, skin measles toxicity Applied with any or several drugses purposes of snake bite and insect sting.
4th, with effect test
Treatment group：This experimental therapy group sample selection example 5 is formulated to be carried out being prepared into tincture according to the method for embodiment 8. Without specified otherwise in tests below, treatment group's medication is according to said method prepared.It is appreciated that any one of embodiment 1-5 It can be prepared according to embodiment 6-10 methods, simply curative effect has part variation, but not influence the reality of the effect of the present invention Apply.
(1) curative effect pain caused to wind-cold-dampness arthralgia
Comparative example：Take commercially available ZHENGQINGFENGTONGNING pill, a 1-4 piece, daily 3-12 pieces.
Use taboo：Pregnant woman and alcohol intolerance person avoid use, avoid entrance eye, and wound is used with caution.
1st, case selection：Treatment group selection causes 30 progress medication observations of patient of pain because of wind-cold-dampness arthralgia.It is right Selected than embodiment because wind-cold-dampness arthralgia causes 10 progress medication observations of patient of pain.Select patient selection's standard：Cause By the wet invasion and attack of chill, the qi and blood fortune caused by causing stagnation of QI-blood or stasis blocking is obstructed, dyshaemia and produce pain.Modern times doctor Learn described rheumatic arthritis, rheumatoid arthritis, sciatica, shoulder and enclose the illnesss such as inflammation, cervical spondylopathy.
2nd, treatment method：Tincture is sprayed directly on to affected part by treatment group to patient, 3 times a day, and spray 3-5 times, is used after spray every time Film covers affected part.Case patient is not belonging to using the listed situation of taboo.Comparative example group takes commercially available ZHENGQINGFENGTONGNING pill, 1-4 piece, daily 3-12 pieces；It is within 2 months a course for the treatment of.
3rd, Outcome measure：
(1) cure：Painful recovery, pain disappears or extremely slight, there is lasting improvement trend.
(2) it is effective：Pain mitigates than before, and take a favorable turn trend.
(3) it is invalid：Pain does not have any improvement than before, still very bitterly.
4th, treatment rate：
Treatment group is treated by the way that 30 patients are carried out with lasting tracking, and medication has the patient cured after 0.5-4 months and is 19 people, effective 6 people, the people of refractory patient 5, cure rate 63.3%, obvious effective rate 20%, total effective rate up to 83.3%, other people because When selecting then patient, cause pain because the cause of disease is not exclusively identical or has other illnesss concurrently, this Chinese medicine composite tincture is in the feelings suited the medicine to the illness Under condition, there can be extraordinary therapeutic effect to patient.
Contrast groups are treated by the way that 10 patients are carried out with lasting tracking, after 4 months i.e. 2 courses for the treatment of of medication, have what is cured Patient is 2 people, effective 4 people, the people of refractory patient 4, cure rate 20%, obvious effective rate 40%, and total effective rate is up to 60%.
Pass through result above, it can be seen that relative to contrast groups, Chinese medicine composition of the present invention is caused by treatment wind-cold-dampness arthralgia The curative effect of pain is substantially better than contrast groups.
5th, treatment group's model case is illustrated：
Lee, female, 35 years old, Guangxi Donglan County, professional aquaculture.Because long-term by damp evil and attacked by the cold and evil, swivel of hand and Foot joint seasonality pain, long-term treatment is not cured, limitation of activity when serious.Tincture of the present invention is persistently sprayed after 3 months, and pain is bright It is aobvious to mitigate, can normal activity, and have lasting improvement trend, cured substantially.
Yuan, man, 27 years old, Longzhou people from county, conceptual design work.Because of long campaigns design, to the computer work time Too long, activity is lacked, with cervical spondylopathy.Tincture of the present invention is persistently sprayed after 0.5 month, and symptom substantially mitigates, and has been controlled after 1 month More.
Chen, female, 49 years old, people from Guangxi Hechi, professional peasant.Because of long-term work, damp evil of having a cold puzzlement, rheumatism 4 years Have a surplus, during seasons change, the pain increased, influence daily life.Tincture of the present invention is persistently sprayed after 3.5 months, and pain substantially mitigates, And have lasting improvement trend, it is continuing with to after 4 months, has cured substantially, is not recurred in 2 years.
(2) to the curative effect of new and old pain caused by beating the stasis of blood swell
Comparative example：The commercially available Chinese bruise of external application is spilt.
Use taboo：Pregnant woman and alcohol intolerance person avoid use, avoid entrance eye, and wound is used with caution.
1st, case selection：New and old pain pain caused by selection is beaten the stasis of blood swell.Select patient selection's standard：Because being damaged by external force Hinder or because beating the stasis of blood swell pain caused patient.
2nd, treatment method：Tincture is sprayed directly on to affected part by treatment group to patient, 3 times a day, and spray 3-5 times, is used after spray every time Film covers affected part.Comparative example external application China bruise, which is spilt, directly sprays or is applied to affected part, 3 times a day, every time spray or smearing 3-5 times.
3rd, Outcome measure：
(1) cure：Painful recovery, pain disappears or extremely slight, there is lasting improvement trend.
(2) it is effective：Pain mitigates than before, and take a favorable turn trend.
(3) it is invalid：Pain does not have any improvement than before, still very bitterly.
4th, treatment rate：
Treatment group is treated by the way that 15 patients are carried out with lasting tracking, and medication has the patient cured after 7-90 days be 10 People, effective 2 people, the people of refractory patient 3, cure rate 66.7%, obvious effective rate 13.3%, total effective rate is up to 80%, and other people are because choosing Then during patient, cause pain because the cause of disease is not exclusively identical or has other illnesss concurrently, this Chinese medicine composite tincture is in situation about suiting the medicine to the illness Under, there can be extraordinary therapeutic effect to patient.Comparative example is treated by the way that 8 patients are carried out with lasting tracking, medication It is 1 people that the patient cured is had after 7-90 days, and effective 4 people, the people of refractory patient 3, cure rate 12.5%, obvious effective rate 50% always has Efficiency is up to 62.5%.
Pass through result above, it can be seen that relative to contrast groups, Chinese medicine composition of the present invention is new and old caused by beating the stasis of blood swell The curative effect of pain is substantially better than contrast groups.
5th, treatment group's model case is illustrated：
It is deep certain, man, 40 years old, Guigang great Xu Zhen Cheung On Est. people.Patient was on October 2nd, 2016, because having some setbacks by motorcycle Overturn, face portion Butt wounds, the stasis of blood is swollen to cause face gross distortion, and EVAC HOSP film making diagnosis is controlled without just being gone home after fracture with tincture of the present invention Treat, spray three to four times, are returned to normal for four days daily, tight hemostasis all disappears for seven days；It is continuing with tincture of the present invention 30, Wound without pain, does not recur so far.
Wei, man, 72 years old.Guigang great Xu Zhen Dong Huang people from villages.Patient is on March 12nd, 2015 in careless traffic accident the year before Left anklebone folding comminuted fracture is caused, is discharged to home after school's hospitalization so far, wound can not heal always, oozes out yellow water not It is disconnected, walk, treated afterwards with tincture of the present invention by difficult carry out of crutch, after 25 days, wound healing；It is no longer rely on turning after three months Cane is walked, and function is recovered substantially, and has lasting improvement sign.
Zhu, man, 50 years old, people from Guigang, professional civil servant.Patient once once opened cranium treatment because of serious cerebral injury, went home Upper limbs is twitched to take place frequently 1 year and had a surplus afterwards, and in May, 2014 is treated using tincture of the present invention, is sprayed when often to be taken out, is used disease after 3 months Shape is relieved, and tic is significantly reduced, basic to cure；To prevent recurrence to be continuing with to after 5 months symptom all disappearances, so far Do not recur.
(3) to snake bite and insect sting, obnubilation, skin measles toxicity patient curative effect
Model case is illustrated：
1. snake bite and insect sting patient's curative effect model case：
Hu, man, 24 years old.Guigang great Xu Zhen Cheung On Est. people.Patient plucks when the July in 2016 of the morning 10 on the 28th in vegetable plot Accidentally by Induced By Coral Snake Bite right index finger during dish, patient's emergency diagnosis and treatment reserve wound with tincture of the present invention and spray from top to bottom, simultaneously Directly rush to first-aid centre of city after being cleaned a wound with clear water, hospital emergency center has been remained in a hospital under observation 48 hours in city, after without occur not Leave hospital after good symptom.
2. stupor, clouded in mind patient's curative effect model case：
It is deep certain, female, 75 years old, peasant.Guangxi Guigang great Xu Zhen folk musics people from village.Patient is confused suddenly in evening in April, 2015 Faint, lip cyanosis are looked pale, and sweating is dripping, senseless, area is each before and after the tincture spray patient chest heart of the present invention of urgent need at that time Spray 5 times, while calling 120 first-aid centres, revived, each sign is as usual after waking up after patient's spray less than 3 minutes.
It is deep certain, female, 83 years old, Guigang port cities and towns Lam Tin Est. people.Patient suffers from the l that gone into a coma after angina pectoris and entered on May 3rd, 2015 Port north hospital is treated 5 days, and Hou Zhuan cities hospital is not improved for 10 days, and the state of an illness is more weighed, and school's suggestion goes home to handle funeral affairs. Through looking into BP76x42, arrhythmia, heart sound is low blunt faint, remains unconscious, for example dead color in face, heart extreme exhaustion, let go at any time and Go.Observe area before and after spraying the heart with tincture of the present invention after the state of an illness respectively to spray 5 times, 10 minutes or so after spray, patient's heart sound improves, beating Slight force, after take blood pressure and risen toAt this moment patient's expression takes a turn for the better, and re-uses tincture of the present invention afterwards after an hour, During afternoon three, patient comes to life, and can enter half bowl of congee, then through herbal treatment, and coordinate tincture to use, patient's energy after 5 months Take care of oneself, sign is as before.
3. skin measles toxicity patient's curative effect model case：
Zeng, female, 48 years old, Guigang great Xu Zhen Shi Gu people from villages.Patient tells that head is suffered from the year before and lost after bleb leaves more afterwards Disease, severe pain, it is impossible to which work and rest, and left vision degradation, eye upper eyelid are slightly sagging, very painful are rear with this Invention tincture sprays affected part treatment, daily 3-4 times, every time spray 4-5 times, and severe pain is alleviated, health after persistently using 1.5 months afterwards It is multiple.
Not certain, female, 38 years old, people from Liuzhou.Patient suffers from urticaria perstans 13 years, breaks out frequently, particularly eat beef or High protein diet is breaking-out, and whole body pimple during breaking-out, block rash company time, itch is unbearably, very painful.Constantly in doctor in 13 years Institute and medication among the people, such as Chinese medicine Ma Xing Shi Gan Tang, Western medicine loratadine tablet, or other mixing treatments, fail radical cure.Use this Invention tincture is treated, daily 3-4 times, and symptom disappears after spraying 4-5 times, 1.5 months every time, is not broken out more than 2 years so far.
It is blue certain, man, 42 years old, people from Nanning.Patient suffers from pin onychomycosis for many years, has improvement using Da Kening symptoms, but be discontinued soon Recur again.Affected part is applied with medical cotton dip in liquid medicine with tincture of the present invention afterwards, 2 times a day, spray 4-5 times every time is fully recovered for 15 days.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair The equal change or modification change completed under bright patent claim, the technical spirit suggested by all present invention, all should belong to Cover the scope of the claims in the present invention.

Claims (10)

1. a kind of Traditional Chinese medicine used as analgesic composition, it is characterised in that be made up of the raw material of following weight part ratio：Ford dutchmanspipe root or herb 3.5-10.5 Part, 3-9 parts of climbing fig, 3-9 parts of gecko, 3-9 parts of laciniate blumea herb, 3-9 parts of Chinese hydrangeavine root-bark, 3-9 parts of safflower, 3-9 parts of frankincense, 3-9 parts of myrrh, 3-9 parts of teasel root, 3-9 parts of native copper, 3-9 parts of lamiophlomis rotata, 2.5-7.5 parts of paniculate swallowwort, 2.5-7.5 parts of the root of Chinese clematis, 2-6 parts of notopterygium root, 0.5-1.5 parts of 2-6 parts of levisticum, 2-6 parts of Radix Angelicae Sinensis, 2-6 parts of turpentine, 1-3 parts of the root of Dahurain angelica, 1-3 parts of borneol and menthol.
2. a kind of Traditional Chinese medicine used as analgesic composition according to claim 1, it is characterised in that by the raw material group of following weight part ratio Into：It is 5-9 parts of ford dutchmanspipe root or herb, 4.8-7.2 parts of climbing fig, 4.8-7.2 parts of gecko, 4.8-7.2 parts of laciniate blumea herb, 4.8-7.2 parts of Chinese hydrangeavine root-bark, red 4.8-7.2 parts of flower, 4.8-7.2 parts of frankincense, 4.8-7.2 parts of myrrh, 4.8-7.2 parts of teasel root, 4.8-7.2 parts of native copper, lamiophlomis rotata 4.8-7.2 parts, 4-6 parts of paniculate swallowwort, 4-6 parts of the root of Chinese clematis, 3.2-4.8 parts of notopterygium root, 3.2-4.8 parts of levisticum, 3.2-4.8 parts of Radix Angelicae Sinensis, 0.8-1.2 parts of 3.2-4.8 parts of turpentine, 1.6-2.4 parts of the root of Dahurain angelica, 1.6-2.4 parts of borneol and menthol.
3. a kind of Traditional Chinese medicine used as analgesic composition according to claim 1, it is characterised in that by the raw material group of following weight part ratio Into：7 parts of ford dutchmanspipe root or herb, 6 parts of climbing fig, 6 parts of gecko, 6 parts of laciniate blumea herb, 6 parts of Chinese hydrangeavine root-bark, 6 parts of safflower, 6 parts of frankincense, 6 parts of myrrh, teasel root 6 parts, 6 parts of native copper, 6 parts of lamiophlomis rotata, 5 parts of paniculate swallowwort, 5 parts of the root of Chinese clematis, 4 parts of notopterygium root, 4 parts of levisticum, 4 parts of Radix Angelicae Sinensis, 4 parts of turpentine, 1 part of 2 parts of the root of Dahurain angelica, 2 parts of borneol and menthol.
4. a kind of Traditional Chinese medicine used as analgesic composition according to claim any one of 1-3, it is characterised in that the native copper is big gun Product pyritum ignited, Radix Angelicae Sinensis is selected from Radix Angelicae Sinensis tail.
5. the preparation method of any one of a kind of claim 1-3 Traditional Chinese medicine used as analgesic compositions, it is characterised in that mainly by following Step is made：By weight, first above-mentioned all raw materials are crushed respectively, is well mixed, obtains mixed-powder；Then take containing one Determine mixed-powder described in the solvent soaking of alcohol concentration, it is overanxious, filtrate is finally collected, filtrate alcohol concentration is adjusted, produces analgesic Chinese medicine composition.
6. the preparation method of a kind of Traditional Chinese medicine used as analgesic composition according to claim 5, it is characterised in that the solvent is selected from One or more in ethanol, white wine, rice wine and yellow rice wine, the alcohol concentration of the solvent is 55-75wt%, the use of the solvent Amount is that 6-15 times of the mixed-powder weight is measured by weight.
7. a kind of preparation method of Traditional Chinese medicine used as analgesic composition according to claim 5, it is characterised in that adjustment filtrate alcohol Concentration is 30-40wt%.
8. the preparation method of a kind of Traditional Chinese medicine used as analgesic composition according to claim 5, it is characterised in that Traditional Chinese medicine used as analgesic is combined Form of Chinese drug is further made in thing, and the form of Chinese drug is selected from tincture, vina, spray, film, pill, paste, liniment and piece One kind in agent.
9. the purposes of the Traditional Chinese medicine used as analgesic composition described in a kind of any one of claim 1-3, it is characterised in that alleviating or treating Applied in pain medication.
10. a kind of purposes of the Traditional Chinese medicine used as analgesic composition described in any one of claim 1-3, it is characterised in that it is clouded in mind, Applied in any or several drugses purposes of skin measles toxicity and snake bite and insect sting.
CN201710491429.9A 2017-01-20 2017-06-26 A kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application Pending CN107137471A (en)

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