CN101244174B - Medicine for treating angiitis and preparation thereof - Google Patents

Abstract

The invention discloses a pearl fumigation agent used for treating vasculitis, which is prepared with rhubarb, olibanum, myrrh, catnip, safflower and pearl powder according to a given weight ratio. The drug has the advantages of heat-clearing and fire-purging, anti-inflaminatory, antibacterial, toxic substances removal and wound healing promotion, quick effects and high cure rate for the treatment of vasculitis.

Description

Vasculitic medicine of a kind of treatment and preparation method thereof

Technical field:

The present invention relates to vasculitic medicine of a kind of treatment and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Vasculitis is a kind of nonsuppurative inflammation with limb artery, vein generation segmental obturation, makes vessel lumen narrow, the organic angiopathy of thromboembolism, mainly involve small artery in the extremity, clinical manifestation is afraid of cold for suffering from the limb far-end, and feeling of numbness is arranged, and foot and shank have the pain of delocalization, continue and intermittent claudication then occurs, toes have rest pain, the aggravation at night, and the toe-end temperature reduces, bleaching or become purple dark-coloured, is the able-bodied disease of a kind of serious harm human body.Often cause the sick damage of limbs generation ischemia or blood stasis, even limbs fester, come off.Bring great psychic pain and financial burden to the patient.Clinical general employing oral drugs, vein or multiple therapies such as intramuscular injection, acupuncture and electrotherapy in the time of can't curing when being in a bad way, adopt the surgical operation amputation more, and the patient is not only painful big, and amputation causes lifelong disability.

Summary of the invention:

Therefore people still exist great serious hope and demand to the vasculitic Chinese medicine medicine of the better treatment of curative effect, up to now, also do not find the report of any relevant pharmaceutical composition of the present invention, the inventor is through research repeatedly, and in conjunction with the checking repeatedly of secret prescription handed down in the family from generation to generation and clinical trial, finally work out the vasculitic herbal fumigation agent of the treatment with better curative effect, thereby finished the present invention.

Purpose of the present invention just provides the vasculitic Chinese medicine pearl fumigation vascular gutron of a kind of more effective treatment.

Another object of the present invention has just provided the preparation method of this Chinese medicine pearl fumigation vascular gutron.

The medicament selection Radix Angelicae Dahuricae of the present invention, Radix Saposhnikoviae, Cortex Lycii, Radix Et Rhizoma Rhei, Olibanum, Myrrha, Realgar, Sanguis Draxonis, Herba Schizonepetae, Borneolum Syntheticum, Flos Carthami and Margarita powder make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat vasculitic recurrence, wherein select for use the Radix Angelicae Dahuricae to be because its nature and flavor suffering, temperature is returned lung, spleen, stomach warp.Have and dispel the wind, dampness, detumescence, analgesic function.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Selecting Radix Saposhnikoviae for use is that temperature is returned bladder, lung, spleen channel because of its property acrid-sweet flavor.Deliver, dispel the wind, win and wet, the analgesic function.Control affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Select for use Cortex Lycii to be because its nature and flavor are sweet, cold, return lung, liver, kidney channel.Heat clearing away is arranged, the function of removing heat from blood.Control empty hectic fever night sweat, the lung-heat cough with asthma is spitted blood, epistaxis, and stranguria with blood is quenched one's thirst, hypertension, carbuncle, malignant boil.Select for use Radix Et Rhizoma Rhei to be because its nature and flavor hardship is cold, return stomach, large intestine, Liver Channel.Have the poison of purging heat, removing mass stagnates, the function of clots absorbing blood.Control the excess-heat constipation, delirium is gone mad, the food stagnation feeling of fullness, dysentery is from the beginning of, tenesmus, stasis of blood menolipsis is closed, lump in the abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, it is red to urinate, carbuncle and ulcer toxic swelling, furuncle, burn.Select for use Olibanum to be because its nature and flavor are arduous, temperature, GUIXIN, liver, spleen channel.Regulating qi and activating blood is arranged, and analgesic therapy chases after malicious function.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select for use Myrrha to be because its nature and flavor are sweet, flat, return Liver Channel.Be used for the blood blood stasis removing that looses, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Select for use Realgar to be because its nature and flavor are arduous, temperature, poisonous, GUIXIN, liver, stomach warp.Dampness is arranged, dispel the wind, parasite killing, antidotal function.Control scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm sting, bromhidrosis, ecthyma, asthma, sore throat, infantile convulsion, hemorrhoid complicated by anal fistula.Select for use Sanguis Draxonis to be because its property sweet-salty is flat, GUIXIN, Liver Channel.Be used for the dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury and lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.Selecting Herba Schizonepetae for use is that temperature is returned lung, Liver Channel because of its nature and flavor suffering.Deliver, dispel the wind, treating blood disorders; Parch to black hemostatic function.The heating that cures cold, headache, laryngopharynx swelling and pain, the apoplexy locked mouth, leaf blood, epistaxis is had blood in stool; Metrorrhagia, puerperal blood faints; Carbuncle, skin ulcer scabies, scrofula.Select for use Borneolum Syntheticum to be because its nature and flavor are arduous, cold, GUIXIN, lung meridian.Logical all keys are arranged, the stagnated fire of loosing, removing nebula makes eye bright, the function of reducing swelling and alleviating pain.Control the apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis.Selecting Flos Carthami for use is that temperature is gone into the heart, Liver Channel because of its nature and flavor suffering.Be used for promoting blood circulation to restore menstrual flow, the blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.

In order to obtain optimum curative effect, medicine of the present invention adds Margarita powder again on the basis of said medicine, and adding Margarita powder is because its property sweet-salty is cold, GUIXIN, Liver Channel.Have tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and expectorant is weighed down in heat clearing away, and removing nebula makes eye bright, the function of removing toxic substances and promoting granulation.Control palpitation with fear, palpitation with a distress feeling, epilepsy, infantile convulsion is twitched, and dysphoria with smothery sensation is quenched one's thirst, the sore throat aphtha, order is given birth to cataracta, and the skin ulcer wound does not close up for a long time.It both can help the cold and cool fraud of all medicines of system, but priming reaches hole key skin thoroughly again, treats vasculitic curative effect the best.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has curative effect preferably in following weight range.

Radix Angelicae Dahuricae 22-28 gram Radix Saposhnikoviae 35-40 gram

Cortex Lycii 45-55 gram Radix Et Rhizoma Rhei 45-55 gram

Olibanum 22-28 gram Myrrha 45-55 gram

Realgar 10-15 gram Sanguis Draxonis 5-10 gram

Herba Schizonepetae 70-80 gram Borneolum Syntheticum 22-28 gram

Flos Carthami 22-28 gram Margarita powder 3-8 gram

Be preferably: the Radix Angelicae Dahuricae 25 grams, Radix Saposhnikoviae 37.5 grams, Cortex Lycii 50 grams, Radix Et Rhizoma Rhei 50 grams, Olibanum 25 grams, Myrrha 50 grams, Realgar 12.5 grams, Sanguis Draxonis 7.5 grams, Herba Schizonepetae 75 grams, Borneolum Syntheticum 25 grams, Flos Carthami 25 grams, Margarita powder 5 grams.

The preparation method of medicine of the present invention is as follows:

One, gets the raw materials ready

1, the Radix Angelicae Dahuricae: choose decontamination, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, again behind the moistening, chip drying.

2, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry.

3, Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting is fried to heavy yellow.

4, Radix Et Rhizoma Rhei: former medicine is chosen clean impurity, big or small stepping, and stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, and dries.

5, Olibanum: choose the sub-impurity of shakeout.

6, Myrrha: choose decontamination, break into fragment.

7, Realgar: grind into impalpable powder, or water flies, dry.

8, Sanguis Draxonis: wipe dust away, the knock fritter in winter dryness weather, is placed on and makes dryly in the Calx altar, takes advantage of crisp grinding into powder then.

9, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries, and slightly fries jaundice.

10, Borneolum Syntheticum: be the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or the product of being processed into that are combined into chemical method for Camphora Lignum Pini Nodi wet goods.

11, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry.

12, Margarita powder: get Margarita and clean, wrap, boiled altogether about 2 hours, take out, clean, smash to pieces with bean curd and water with cloth, add water a little, be ground into superfine powder, drying.

Two, preparation

The Radix Angelicae Dahuricae, Radix Saposhnikoviae, Cortex Lycii, Radix Et Rhizoma Rhei, Olibanum, Myrrha, Realgar, Sanguis Draxonis, Herba Schizonepetae, Borneolum Syntheticum, Flos Carthami pulverize separately with described weight proportion add the Margarita powder mixing and stirring again, make intermixture.

Medical instrument of the present invention has clearing away heat-fire, antiinflammatory, antibiotic, removing heat from blood, the functions such as holding back skin ulcer of drawing out pus by applying a plaster to the affected part, and is used for the treatment of the vasculitis good effect, instant effect.

The specific embodiment:

Below further set forth the beneficial effect of medicine of the present invention by testing example.These tests comprise pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention (logical to call vascular in the following text).

The animal toxicity test data of [test example 1] medicine of the present invention

1, get 10 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5 kilogram scrapes off the shank fine, soft fur, with being immersed in the shank modeling in 20 second that cotton swab in the acetic acid is pressed in rabbit, the diameter 5-10mm of mucosa ulcer.

2, the logical 500 gram warm water of putting into of 10 gram vasculars are stirred into medicinal liquid, smear the ulcer place with medicinal liquid, every day three times, in one week of logotype, 10 rabbit leg ulcer faces all heal after seven days.

Evidence: medicine of the present invention does not have toxic and side effects.

The clinical trial observations of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 130 examples for medical treatment, wherein male 73 examples, women 57 examples, age 20-30 year 16 examples, 31-40 year 33 examples, 41-50 year 40 examples, 41 examples more than 50 years old.

2, diagnostic criteria

Light-duty vasculitis: medical history half a year, the lower limb congestion and swelling pain, scorching hot, suffer from the limb hypohidrosis, palor, numb or send out cool.3 courses of treatment are fully recovering.

Heavy vasculitis: medical history is more than 6 years, and trouble main drive arteriopalmus obviously weakens or disappears, and the trouble limb is lossless, and numb is cool, red and swollen scorching hot distending pain, and the skin purple is secretly.Foot or muscles of leg muscular atrophy contract or acra ulcer, gangrene, patient's intermittent claudication, walking be less than 10 steps, pain during resting state, tuck and when sleeping pain subtract slightly, see that from symptom the patient is extremely painful.

3, Therapeutic Method

When burning to the stove to 80 ° of temperature with clear water 6-8 kilogram, logical the putting under the boiled end of water of 50 gram vasculars, limb is placed thereon suffering from, cover woollen blanket above to reach best fumigating effect, when treating that water temperature in the basin is reduced to the temperature that human body can bear, be put in cleaning 10-20 minute of carrying out in the water slowly and promptly take out suffering from limb.Every day, sooner or later once the basin Chinese medicine can use 2-3 days repeatedly, changed the water dosing more again.As open sore part disunion of a specified duration, it is better that available Margarita powder is spread on the affected part effect.Every dose of medicine 500 grams were a course of treatment in available one month, logotype 4-6 course of treatment.Avoid between taking medicine: cigarette, wine, the thing of pungent, fish raw meat.Recover back cigarette, wine, pungent, fish raw meat need not to avoid again.Heavy patient continues this medicine of development person as the state of an illness and also can cure as the person that clips the toe, need not amputation again.

4, efficacy assessment standard

Produce effects: transference cure, dorsal artery of foot or posterior tibial artery are beaten and are recovered normal, and the position test transfers feminine gender to, recovers former work.Follow up a case by regular visits to 1-3 and do not have recurrence.

Take a turn for the better: clinical symptoms significantly alleviates, and the painful and intermittent claudication of tranquillization disappears, and suffers from limb color of the leather and temperature and before is clearly better, and the more preceding obvious improvement of beating of dorsal artery of foot and posterior tibial artery can be engaged in slight work.

Invalid, do not reach the improvement standard, symptom and sign do not have the improver.

5, therapeutic outcome: see the following form

In 3-6 the course of treatment, with Drug therapy patient's 130 examples of the present invention, the result shows: light-duty vasculitis 76 examples, and produce effects 75 examples, 1 example that takes a turn for the better, total effective rate is 100%; Heavy vasculitis 54 examples, produce effects 50 examples, 3 examples that take a turn for the better, invalid 1 example, total effective rate is 98.1%.

Claims (3)

1. treat vasculitic medicine for one kind, it is characterized in that: it is to be made by the crude drug in the following weight range:

Radix Angelicae Dahuricae 22-28 gram Radix Saposhnikoviae 35-40 gram

Cortex Lycii 45-55 gram Radix Et Rhizoma Rhei 45-55 gram

Olibanum 22-28 gram Myrrha 45-55 gram

Realgar 10-15 gram Sanguis Draxonis 5-10 gram

Herba Schizonepetae 70-80 gram Borneolum Syntheticum 22-28 gram

Flos Carthami 22-28 gram Margarita powder 3-8 gram.

2. the vasculitic medicine of treatment according to claim 1, wherein the preferred weight of each crude drug is: the Radix Angelicae Dahuricae 25 grams, Radix Saposhnikoviae 37.5 grams, Cortex Lycii 50 grams, Radix Et Rhizoma Rhei 50 grams, Olibanum 25 grams, Myrrha 50 grams, Realgar 12.5 grams, Sanguis Draxonis 7.5 grams, Herba Schizonepetae 75 grams, Borneolum Syntheticum 25 grams, Flos Carthami 25 grams, Margarita powder 5 grams.

3. according to the preparation method of claim 1 or 2 described treatment vasculitis medicines, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Radix Angelicae Dahuricae: choose decontamination, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, again behind the moistening, chip drying;

(2) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(3) Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting is fried to heavy yellow;

(4) Radix Et Rhizoma Rhei: former medicine is chosen clean impurity, big or small stepping, and stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, and dries;

(5) Olibanum: choose the sub-impurity of shakeout;

(6) Myrrha: choose decontamination, break into fragment;

(7) Realgar: grind into impalpable powder, or water flies, dry;

(8) Sanguis Draxonis: wipe dust away, the knock fritter in winter dryness weather, is placed on and makes dryly in the Calx altar, takes advantage of crisp grinding into powder then;

(9) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries, and slightly fries jaundice;

(10) Borneolum Syntheticum: be the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or the product of being processed into that are combined into chemical method for Camphora Lignum Pini Nodi wet goods;

(11) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(12) Margarita powder: get Margarita and clean, wrap, boiled altogether about 2 hours, take out, clean, smash to pieces with bean curd and water with cloth, add water a little, be ground into superfine powder, drying;

(2) preparation

The Radix Angelicae Dahuricae, Radix Saposhnikoviae, Cortex Lycii, Radix Et Rhizoma Rhei, Olibanum, Myrrha, Realgar, Sanguis Draxonis, Herba Schizonepetae, Borneolum Syntheticum, Flos Carthami pulverize separately with described weight proportion add the Margarita powder mixing and stirring again, make intermixture.