CN108542956A - A kind of pharmaceutical composition and its application - Google Patents

Abstract

The present invention relates to a kind of pharmaceutical composition and its applications, belong to technical field of traditional Chinese medicines, specifically include following raw material, charred RADIX SANGUISORBAE, giant knotweed, Cortex Phellodendri and borneol.The present invention uses simple Chinese medicine, is configured to powder, is directly spread on burn and scald position, easy to use, effect is good.

Description

A kind of pharmaceutical composition and its application

Technical field

The invention belongs to scalds and burns drug fields, and in particular to a kind of pharmaceutical composition and its application.

Background technology

Burn and scald is a kind of skin of thermal energy infiltration people, causes skin surface or table undertissue damage or necrosis in various degree Property illness.Burn and scald once occurs for people, brings insufferable pain to people immediately, while the later stage of burn and scald restores, also most It is easy raw scar cicatrization.

When burn and scald just occurs, patient is mostly in great pain, or even can not coordinate the treatment of doctor, and treatment is caused to be prolonged It is slow, and treat in time, treated as soon as possible is treated to burn and scald, therefore, lack it is a kind of can be safe and effective in burn and scald Analgesic drug product.

Certainly, when burn and scald occurs, medicine in the prior art, therapeutic process is slow, and incrustation is slow, therapeutic effect Difference, is easy infection in treatment, cure rate is low.Seriously affect patient's daily life.Meanwhile drug therapy in the prior art, it is long Phase exposes, and is easy to grow new virus and infection, especially summer etc., can also cause inflammation etc., and these are viral and scorching Disease, less serious case then delay to treat the time limit, and severe one then causes other complication, and not only burn and scald or tumble injury etc. can not treat in time, New slight illness can be also brought, enables patient's economic loss big, spirit endures torment to the fullest extent.

Drug in the prior art needs patient's dressing repeatedly, repeatedly bears the pain, and economic and spirit all endures torment to the fullest extent.

Invention content

In order to solve the deficiency in burn and scald treatment in the prior art, the present invention provides a kind of good analgesic effect, incrustations Soon, cure rate height, the not pharmaceutical composition of easy infection and its application in various treatments.

The technical problem to be solved in the present invention is achieved through the following technical solutions：

A kind of pharmaceutical composition, including following raw material：Charred RADIX SANGUISORBAE, giant knotweed, Cortex Phellodendri and borneol.

Above-mentioned pharmaceutical composition includes the raw material of following quality parts ratio：90-110 parts of charred RADIX SANGUISORBAE, giant knotweed 20-40 10-20 parts of part, 20-40 parts of Cortex Phellodendri and borneol.

Further, include the raw material of following quality parts ratio：100 parts of charred RADIX SANGUISORBAE, 30 parts of giant knotweed, 30 parts of Cortex Phellodendri and ice 15 parts of piece.

Pharmaceutical composition of the present invention is being prepared for treating for treating the application in burn and scald medicine.

Further, described for treat burn and scald medicine to refer to for treating light Ⅱ° burn and scald medicine and/or for controlling Treat depthⅡ° burn and scald medicine.

Further, it is described for treat depthⅡ° burn and scald medicine refer to for treat head and/or face depth II ° of burn and scald medicine.

Application of the pharmaceutical composition of the present invention in preparing analgesic drug product, the analgesic drug product be for tumble injury, Analgesic drug product in burn and treatment of scald.

Pharmaceutical composition of the present invention is being prepared for treating the application in tumble injury drug.

Beneficial effects of the present invention：

In the present invention, xeraphium type preparation is developed into using Chinese herbal medicine, with bitter cold to heat symptom-complex, removes relieving heat and toxins, promoting blood circulation to remove blood stasis, one Secondary property blocking treatment and burn and scald diffusate volcanic crater bursting point is shut, ensure that human body nutrition, such as albumen etc. are no longer lost in, Vigour remains, and resistance does not subtract, and more significantly improves, and necessarily more relieves pain soon, incrustation speed, treatment is saved worry, primary to add medicine to, six days Left and right recovery from illness,

Pharmaceutical composition in the present invention is spread on wound when burn and scald just occurs, and energy quickly alleviating pain alleviates patient's pain It is bitter, it is ensured that treatment in time.

Pharmaceutical composition in the present invention can prevent the bacterial virus of outside green when being treated for burn and scald and tumble injury The invasion and infection of purulence bacillus etc..Extra unnecessary telangiectasis can be more prevented to thicken the trouble of hyperplasia, to only To one's great satisfaction, recovery from illness speed, newborn skin do not see that the edge of wound, surprising curative effect show the power and compression therapy of the invention Profoundness.Over the course for the treatment of, the trace for staying scar is not shown, since thermal energy acts on, just damages body, personal original tape does not connect packet The basic high temperature sterilization disinfection of bacterium is included, exposure treatment and inappropriate medication in the prior art is avoided and leads to capillary transverse and longitudinal It grows thickly, subcutaneous tissue gathers in heaps, so that its epidermis is thickeied, or even form the uneven, scar that follows the string.

Specific implementation mode

Reach the technological means and effect that predetermined purpose is taken for the present invention is further explained, it is right with reference to embodiments Specific implementation mode, structure feature and its effect of the present invention, detailed description are as follows.

Pharmaceutical composition in the present invention, specifically includes formula as below：Charred RADIX SANGUISORBAE, giant knotweed, Cortex Phellodendri and borneol.When preparation, After raw material is mixed, it is developed into dry powder preparation, you can use.

In the present invention in preparation, mixing after the separately made pulvis of raw material can first can also be mixed and be milled into powder together again The larger particle of grain size is continued to smash to pieces and refiltered by agent, last obtained pulvis after two layers of crocus cloth filters, and one has drived straight on to again It bottles after filtering spare.

In the present invention, raw material needs to be milled to pulvis, and pulvis grain size is 5mm-15mm, is convenient for absorption of human body.

Pharmaceutical composition in the present invention can be used for relieving pain, treat burn and scald and treatment tumble injury, especially burnt to light Ⅱ° Scald and/or depthⅡ° burn and scald significant effect are more focused on the head for belonging to human body sun portion when it is used for depthⅡ° burn and scald And face.

In the present invention, the pharmacological action of drug is as follows：

First, in pharmaceutical composition of the invention, selected raw material charred RADIX SANGUISORBAE contains a large amount of tannins and saponin, and antimicrobial spectrum is wide, and There is the effects that hemostasis, anti-inflammatory.Charred RADIX SANGUISORBAE taste is bitter, sour, puckery, is slightly cold, Return liver, large intestine channel,

Due to the active ingredient that it contains, therefore charred RADIX SANGUISORBAE has application below：

1. for having blood in stool for lower burnt blood-heat bleeding, hemorrhoid blood, bloody flux, hematuria, uterine bleeding.Decoction or compatibility sophora flower treating hematochezia can be applied alone； The compatibility coptis, root of Aucklandia lappa Decne control bloody flux；Compatibility Radix Rehmanniae, the root bark of tree peony control uterine bleeding etc..

2. being used for scald and carbuncle swells, sore, eczema etc..It can be ground to the powder with Radix Sangusorbae, sesame oil dresses；Or dense pan-fried, yarn Cloth soaks deposited or decoction washout, or is made as ointment with calcined gypsum and applies outside.

However other medicines are equipped in the present invention, so that its application is not limited only to scald, is additionally operable to electric arc scald, pitch Scald etc..

Secondly, one of raw material composition in present invention borneol, is the crystallization obtained from the resin and volatile oil of kapur, It is intimate pure d-Bomeol.Containing there are many ter penoids in the resin and volatile oil of kapur.In addition to borneol, still contain humulus grass The sequiterpenes such as alkene, beta-elemene, carypohyllene, oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, kapur glycol The triterpenoids such as ketone, erythrodiol.

Borneol, acrid flavour is bitter, cool, is slightly cold, thoughts of returning home spleen and lung warp.Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain, treatment hot eyes pharynx disease, angina pectoris, Coronary heart disease etc..Curing mainly function has logical all keys, dissipates stagnated fire, removes screen improving eyesight, swelling and pain relieving.Control apoplexy lockjaw, pyreticosis coma, frightened epilepsy phlegm Fan, deafness with qi stagnation, larynx numbness, aphtha, tympanitis, carbuncle swells, hemorrhoid, mesh also screen film, enterobiasis.

Again, the giant knotweed in the present invention, mildly bitter flavor, cold nature, Return liver courage lung channel have removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, Removing blood stasis and analgesics, relieving cough and reducing sputum effect are cured mainly for jaundice with damp-heat pathogen, stranguria with turbid discharge, and under band, arthralgia pain due to rheumatism, carbuncle sore tumefacting virus, extreme misery scalds Wound, Amenorrhea, abdominal mass, instep beat damage, cough with lung heat.

Finally, the Cortex Phellodendri in the present invention, taste bitter and cold return kidney, bladder, large intestine channel, function：Heat-clearing and detoxifying drug；Heat-clearing is dry Wet medicine.It cures mainly：Damp-heat dysentery, diarrhea, jaundice；Under nocturnal emission, stranguria with turbid discharge, band；Hectic fever due to yin labor heat, night sweat；And aphthae；Hot eyes is swollen Bitterly；Skin sore；Skin eczema.For a variety of damp and hot carbuncles, fever due to yin deficiency, large intestine channel heat-clearing, eliminating dampness, purging intense heat and detonicating moves back void Heat.

The main component of obakunone Cortex Phellodendri bark is jamaicin（Berberine）Separately contain phellodendrine（Phello dendrine）, magnoflorine（Magnoflorine）, jateorrhizine（Jatrorrhizine）, palmatine（Palmatine, Palmatine）, candicine（Candicine）, Dauricine（Menisperine）Etc. a variety of alkaloid in addition, Still contain obakulactone（Obaculactone）, obakunone（Obacunone）, obacunonic acid（Obacunonic acid）And 7- Dehydrogenation stigmasterol（7-Dehydrostigmasterol）, cupreol（β-Sitosterol）, campesterol （Campesterol）, green fluorescent acid（Lumicaeruleic acid）, Dictamnolide（Dictamno- lide）Wampee tree Skin is containing such as a variety of alkaloids and lactone, sterol, lymphatic temperament such as jamaicin, magnoflorine, phellodendrine, palmatines

The present invention is according to the principle of Chinese medicine monarch, and monarch drug in a prescription selection charred RADIX SANGUISORBAE, itself processes big fire stir-bake to brown, and high temperature sterilization kills Malicious sustainability；Adjutant use giant knotweed, can remove damp and hot, promoting blood circulation to remove blood stasis, analgesic therapy and extensively it is antibacterial, it is antiviral；Cortex Phellodendri is ministerial drug, heat-clearing Eliminating dampness, purging intense heat and detonicating, reducing the asthenic fever；History medicine is borneol, clearing away heat to and alleviating pain, but do not know burn and scald exudation it is mostly be the slow chief-criminal's misfortune of recovery from illness It is first.

After above-mentioned several pharmaceutical compositions, the performance of drug can be obtained fully discharging, while in burn and scald discharge surface shape At enclosed environment, cause the perverse trend of external environment that cannot enter internal, human internal environment itself repairs positive, power of regeneration production It is raw, it is that exposed sexual trauma becomes the wound for having management and control.Such as borneol, there is the benefits of inducing resuscitation of having one's ideas straightened out, modern medicine thinks that its is right Brain centres nerve has effect, and then other raw materials is coordinated to generate analgesic, effect promoting blood circulation and removing blood stasis, to promote in shorter time Health skin.

Drug in the present invention selects bitter cold drug, the heat symptom-complex of corresponding burn and scald that can remove relieving heat and toxins, promoting blood circulation mostly The stasis of blood is dissipated, disposable blocking treatment and shuts burn and scald diffusate volcanic crater bursting point, ensure that human body nutrition, such as human body protein Deng being no longer lost in, vigour remains, and resistance, which does not subtract, more to be significantly improved, and necessarily more relieves pain fast, and incrustation speed, treatment is saved worry, and one Secondary medicine-feeding, light burn and scald scar are fully recovered for general six days or so.

In the present invention, the quality parts ratio of each raw material is：90-110 parts of charred RADIX SANGUISORBAE, 20-40 parts of giant knotweed, Cortex Phellodendri 20- 40 parts and 10-20 parts of borneol.

Preferably, 15 parts of 100 parts of charred RADIX SANGUISORBAE, 30 parts of giant knotweed, 30 parts of Cortex Phellodendri and borneol.

Pharmaceutical composition in the present invention can form artificial pseudomembrane in burn and scald treatment and tumble injury.General burn and scald There are three types of quartering, i.e., I °, light Ⅱ°, depthⅡ° and III ° of burn and scald are not, for light Ⅱ° burn and scald, generally to break bubble and put Go out to ooze hit liquid after spread medicine composite for curing in the present invention again, hit liquid in order to block to ooze and constantly exosmose（Liquid is hit in burn and scald extravasation The characteristics of being mostly burn and scald illness and the refractory arch-criminal in this field）, need the opposite drug that can be treated or method To realize.Said effect can be realized in pharmaceutical composition in the present invention, is spread on burn and scald surface, initially forms micro-wet Drug pseudomembrane, that is, form barrier, blocked the bursting point at volcanic crater, also won the disease of time active treatment burn and scald.This A pseudomembrane due to there is constant weight, therefore has pressurization in the later stage, it is therefore intended that prevents the mostly raw scar of burn and scald, plays medical Elastic sleeve acts on.

Pharmaceutical composition in the present invention, the manufactured drug substance's pseudomembrane formed after being sprinkled due to drug, with following work With：

First, the damage of lesion germ virus and thermal energy to body effectively can be constantly fought, health skin or tumble injury is promoted to restore Process.

Secondly, the artificial pseudomembrane of formation can stop oozing and hit liquid and continue to exosmose, keep the vigour of body, improve in time Resistance promotes body to utilize itself repair ability, in advance health skin, shortens the course for the treatment of.

Again, artificial pseudomembrane forms tangible barrier, and blocking, which is oozed, hits, can outer bacteriological protection, virus, Pseudomonas aeruginosa etc. pollute and Invasion, avoid wound from being infected again, influence treatment process.

Finally, this drug pseudomembrane wound surface formed weight, be equivalent to medical elastic set pressurization, by burn and scald with And the scar that will be generated in tumble injury is eliminated in the treatment, and then beauty treatment and the skin of new health are directly grown, it prevents new The generation of scar.

Pharmaceutical composition in the present invention is directly spread on the wounds such as burn and scald, tumble injury, without daily or repeatedly change Medicine avoids multiple dressing, and feeling of pain and patient's caused patient toss to and fro again, takes, and multiple medication Words, cost are big.

Pharmaceutical composition in the present invention, with other treatment burn and scalds, tumble injury and analgesic drug etc. compared with, without more Secondary medication repeatedly, a drug, effect is good, saves a variety of costs such as time, cost, easy to use, direct figure is spread, nothing Other auxiliary appliances such as gauze and carrier are needed, is used more preferable.

Embodiment 1

Raw material is weighed respectively according to 15 parts of 100 parts of charred RADIX SANGUISORBAE, 30 parts of giant knotweed, 30 parts of Cortex Phellodendri and borneol, wherein charred RADIX SANGUISORBAE is direct Purchase Holy Land fillet through bulk production stir-bake to brown sustainability, then form fine powder with the directly grinding of the giant knotweed of purchase, Cortex Phellodendri and borneol, Then by fine powder by after two layers of filtered through gauze to get the pharmaceutical composition in the present embodiment.

Embodiment 2

Raw material, wherein giant knotweed, Cortex Phellodendri and ice are weighed respectively according to 10 parts of 90 parts of charred RADIX SANGUISORBAE, 20 parts of giant knotweed, 20 parts of Cortex Phellodendri and borneol Piece is the live drug of purchase, and charred RADIX SANGUISORBAE is cleaned, is sliced, is dried for Radix Sangusorbae root, then uses bulk production stir-bake to brown sustainability, these All it is the conventional treatment method of existing garden burnet, it, can also individually will be every then with the giant knotweed of purchase, Cortex Phellodendri and borneol mixed grinding The grinding of a ingredient, remixes, but it is last need by after two layers of filtered through gauze to get the pharmaceutical composition in the present embodiment. After filtering, the grain size of pharmaceutical composition is about 5-15mm.When being spread on wound, convenient for absorbing, grain size is too big, and drug is not only not easy It absorbs, and drug is applied sprinkled with limit, the subtle wound in part can not be sprinkled into, and diameter of aspirin particle is too small, not easy to use.

Embodiment 3

Raw material is weighed respectively according to 20 parts of 110 parts of charred RADIX SANGUISORBAE, 40 parts of giant knotweed, 40 parts of Cortex Phellodendri and borneol, and above-mentioned raw materials are ground and are made At pulvis, pulvis by after two layers of filtered through gauze to get the pharmaceutical composition in the present embodiment.

1000 slight burned patients are selected at random, by manufactured pharmaceutical composition in above-described embodiment 1, painting is spread on trouble Person's wound surface,

Raw material is weighed according to above-mentioned mass fraction, is then ground to powderous preparations, is applied in various burn and scalds, Classification treatment system Count effect such as table 1：

Application examples of the pharmaceutical composition of the present invention in treating burn and scald

Clinical example 1：

Raw material is weighed respectively according to 15 parts of 100 parts of charred RADIX SANGUISORBAE, 30 parts of giant knotweed, 30 parts of Cortex Phellodendri and borneol, and above-mentioned raw materials are ground and are made At pulvis, pulvis by after two layers of filtered through gauze to get the pharmaceutical composition in the present embodiment.

2505 burn and scald personnel are found, the pharmaceutical composition that above-described embodiment is obtained is respectively used to above-mentioned burn and scald people Member, wherein after burn and scald personnel have severe to have slightly, and painting is spread, during treatment, if drug is not touched down, it is not necessarily to dressing, If unexpected, local wound drug is caused to touch off, can continue to apply and spread.In 2505 burned patients, severe burn is about 50 People, remaining is slight burn and scald.And in patient, no pregnant woman, medicine-less allergy patient.

After observation, the conclusion such as table 1 is obtained：

Table 1：

Wound factor	Scald	Fire wound	Electric guanidine wound	Gas is scalded	Pitch is burnt	Rusting is hindered	It amounts to
								Number	1000	1000	100	200	5	200	2505
Without scar number after healing	994	976	95	200	4	200	2454
								Light scar number is stayed after healing	6	24	5	0	1		51
Cure rate	100%	100%	100%	100%	100%	100%	98%

By table 1 it is found that the pharmaceutical composition of the present invention, when being applied to the treatment of various burn and scalds, cure rate is higher, most of to suffer from Person has fully recovered.There are mild scars for minority, and through ex-post analysis, a small number of there are the burned patients of mild scar, burn and scald for severe Hinder patient, and the scar that wound leaves is lighter, does not scrutinize, it is difficult to find.

By table 1 it is found that the pharmaceutical composition of the present invention all has therapeutic effect for the scar of various burn and scalds, And after treating, due to the pseudomembrane formed before, the generation of scar is avoided, therefore without scar after Most patients treatment.

Clinical case 2

Mr. Li, male, adult are watered the hand of Head And Face, chest and left upper extremity by deep fat accidentally when carrying out work indigenous oil refining Wrist, after happening, patient pain's sense is strong, after diagnosing, it is found that Head And Face, chest and left upper extremity are that depthⅡ° burning is scalded Wound.The pharmaceutical composition in embodiment 2 is spread on traumatic part immediately, then normal care, wound is avoided to be infected again.It sprinkles Afterwards, patient pain, which feels, disappears, and after 12 hours, wound surface forms a scab to form pseudomembrane, and pseudomembrane is in dry and hard shape；During nursing, Note that avoiding pseudomembrane impaired, ensure the integrality of pseudomembrane.Third day continues to observe, and pseudomembrane is further done but, at this point it is possible to Cotton swab press dry pseudomembrane but, sees if there is secretion discharge；There is a small amount of secretion discharge, then wiped secretion with cotton swab, With hydrogen peroxide to the wound disinfection after wiping；4th day, pseudomembrane had a small amount of crackle, no secretion.5th day, most crackles were stuck up It rises, there is macroscopic fresh and tender red meat bud to expose under naked eyes visible crack；The 6-7 days, 50% or more pseudomembrane and crackle fell off, When 10th day or so, pseudomembrane and crackle all fall off, wound healing, the new skin grown with it is without exception before, wound without Scar.

Note that if during nursing, nursing staff spreads medicinal powder excessive so that drug forms a thick layer of, then can Decrustation and cure time are postponed, cure time is at least postponed 3 days at this time.

Since the body traumatic part of people belongs to sun, blood circulation is fabulous, so Head And Face is after using pharmaceutical composition six days, entirely Portion's decrustation is cured.Since the wrist portion of chest and left upper extremity is more slightly lower than head, these positions are using after pharmaceutical composition the Six days, be dispersed in it is dry and cracked, after 10 days or so, full recovery, with other area skin indifferences of body.

In the present embodiment, patient obtains satisfied therapeutic effect only with medicine composite for curing, disposable to use Medicine debridement, disinfection, disposably spreads pesticides, and reduces bothering for the daily dressing of patient.Decrease the pain etc. brought when dressing simultaneously Pain.It when pharmaceutical composition in the present embodiment is spread on patient injury, relieves pain immediately, while drug is due to borneol and other originals The effect of material starts promoting blood circulation and removing blood stasis.

In the present embodiment, scalds burn and just occurred soon, to ooze and hit that liquor ratio is less, if malpractice, thermal energy extends expansion in length and breadth , or even next with the foreign substance removing function of own cells, metabolism is reinforced, and oozes that hit liquid more naturally, therefore needs are more early controls It is better to treat.When burn and scald occurs soon, vigour remains, and sprinkles the pharmaceutical composition of the present invention, forms pseudomembrane on wound face, So that it is become micro-wet by the dry drug for hitting the liquid imbibition present invention is oozed, 12 hour left and right trunk but, it is bad not fall, according to one As nurse, avoid wound clashing and breaking etc. again, then body head belongs to sun, therefore about five, six days, wound did scab and splits, and has scarlet tender skin It presents, then does scab and fall off, the new skin of brand-new and original indifference is presented.

In this clinical case, if patient traumatic part in lower body, takes around two weeks or so, wound ability all in upper body It is dry and cracked or fall off, the new skin of brand-new and original indifference is finally presented.

Existing therapeutic scheme

When burn and scald occurs, in the prior art, usually first large dosage infusion, specially colloidal solution, crystalloid fluid, in addition antibacterial Element, since the general viscosity of colloidal solution is high, good penetrability mainly has albumen, dextran, hydroxyethyl starch injection liquid etc.；Crystal General viscosity is low, can rapidly input, mainly by groups such as 0.9% sodium chloride, 5% glucose, 5% G/NS, ringer's solutions At the Clinical practice of colloidal solution and crystalloid fluid is 1:2.And III ° or more of serious burn and scald even also needs to defeated whole blood.

Above-mentioned therapy is required to expose wound daily and carries out coating, and during this, when coating, wound is not formed a scab, It exposes always, increases the chance of the invasion such as germ, bacterium, these are also to lead to the refractory basic reason more of burn and scald.This hair Bright therapeutic scheme effectively prevents the puzzlement of pain, improves resistance, shortens the course for the treatment of, also avoids scar sequelae, Need the trouble of surgery skin grafting again.

When burn and scald occurs, if not using drug, septicemia, charrin's disease etc. are easily caused.Clinical treatment In, there is precedent the burn and scald scar that all types of burn and scald malpractices leave occur and has necessarily been caused if scar leaves Organ dysfunction, for example Shangzhi's ancon burn and scald malpractice or do not control, be bound to influence ancon stretches Qu Gongneng etc., if It does not infect, then reply herein probably needs even more than half a year, finally still treated there are the clinical example of scar some months In it is innumerable.Also because wound can not and duration it is good, need to do the clinical trial example made skin graft.

There is also the potential threats of more steroid scars etc. for the quality method of the prior art, or even cause organ dysfunction etc.. If only excluding to infect and surprisingly, clear-cutting forestland probably needing even more than half a year, finally can also leave scar some months.

In the treatment of burn and scald, clinical characters are to ooze regardless of weight and hit the outflow of liquid and can inherently consume the machine of people Body resistance and ability degree, once malpractice, clinical drug effect is slow, and common is daily dressing stimulation, is exposed to outside, very To directly exposure treatment, the resistance of body can be reduced.In the present invention, after pharmaceutical composition is spread, topical application of drug of liquid envelope is hit by means of oozing It closes and hinders face, it is substantially motionless, wait for the disposable new skin president of 5-6 days new health good.In addition doctor once cleans, once spread Medicine, the primary small pain of patient, relieves pain, decrustation of fully recovering after one week or so, short treating period immediately after medication, and pain is small, and scar does not stay, It is gone out in the treatment.

When scalding burn due to traditional treatment, it is daily or the next day dressing, and the speed that forms a scab is slow, causes wound sudden and violent Dew, infection chance increases, meanwhile, patients ' psychological also can be frightened nervous when dressing, and thought pressure is big, thus resistance also with when Between postponement, consumption is further added by, then necessarily reduce resistance, while the recovery of wound can postpone even half a year half a month, simultaneously It is also possible to having scar sequelae.And these, all the present invention can be avoided and be solved.

In the present invention, the scar refers to the scar of the described burn and scald sequelae of people's custom, and medicine through the invention Compositions, due to that can form the shielding action of pseudomembrane, while pseudomembrane can also play the role of therapeutic compression so that after treatment not Scar, skin is stayed to be restored to normal skin.Those skilled in the art know, if burn and scald treatment is inappropriate, Pseudomonas aeruginosa, Bacterium, virus etc. are impossible to guard against, most easy infection, and in the drug therapy of the present invention, especially for shallow two degree of burn and scalds, effect Obviously, treatment time head only needs one week or so, after drug sprinkles, and liquid imbibition is hit by secreted the oozing of the surface of a wound and body itself, Micro-wet pseudomembrane is formed, thoroughly does but form a scab as time goes by, after general 12 hours, that is, has sealed wound face, pseudomembrane rises To the effect of protection wound, simultaneously because the gravity of pseudomembrane, causes it that can have certain pressurization to limit to skin, and this weight It is just right, if pseudomembrane is too thick, blood circulation is influenced, delays to reply, if kicking the beam, without pressure, pressurization is cannot achieve and makees With.This pressurization controls capillary amount of blood supply under pseudomembrane, also limits the madness life of capillary under pseudomembrane It is long, limit the excessive accumulation of collagenous fibres.In the present invention, by the object for having matter containing pharmaceutical properties, pseudomembrane is formed, and again Amount cooperation human organism repair function itself, limits to ooze and hits liquid and do not losing, body high-grade nutrient remains, and ensure that wound in short-term Between rapid rehabilitation.

The pharmaceutical composition of the present invention does not show the trace for staying scar over the course for the treatment of, since thermal energy acts on, just damages Body, personal original tape do not connect including bacterium basic high temperature sterilization disinfection, avoid exposure treatment in the prior art and inappropriate Medication and cause capillary transverse and longitudinal to be grown thickly, subcutaneous tissue gather it is in heaps, make its epidermis thicken, or even formed it is uneven, lose Remove the scar of elasticity.

In the prior art, for the treatment of burn and scald, it is not to use infusion, is exactly a large amount of antibiotic, though there are crystalloid fluid and glue First three 24 hours therapeutic scheme of body fluid, this be it is necessary for acute disease, large area, the treatment of III ° or more burn and scald, it is right In three degree of general small area, it is two degree shallow, weigh two degree, the treatment of shallow first-degree burn, it is desired nonetheless to the drug for coordinating the present invention is controlled Therapeutic effect is more preferably, moreover it is possible to reduce high financial burden.

Clinical case 3

Marquis so-and-so, man, adult.Summer fights with people, and the hot water of other side's electric kettle is poured on marquis so-and-so ridge.Patient's moment aches Unbearably, entire back blister protrusion is sent to hospitalize to pain through family members.After diagnosing, patient's back is attached most importance to II ° and is scalded.

Debridement, disinfection is carried out to patient first, then the epidermis ruptured already is cut with surgical scissors, is cutting epidermis Wound on, sprinkle the pharmaceutical composition in the embodiment of the present invention 3 immediately, after sprinkling it can be seen that, the present invention in medicine group Conjunction object, which is oozed, hits liquid imbibition into micro-wet, and slowly forms pseudomembrane；

Then by the blister on the other wound faces of patient's back（Blister size is similar to egg size）It is cut off, is put with surgical scissors Go out blister liquid, entire wound face fold is got up, and the pharmaceutical composition in the embodiment of the present invention 3 is sprinkled, and is entirely oozed and is hit liquid and inhaled by drug It receives, becomes dry, patient's face no pain sense at this time, inquiry says that feeling of pain disappears；The drug that drying is got up simultaneously, slowly Pseudomembrane is formed, is covered on wound.

After the pharmaceutical composition for sprinkling the present invention for the first time, patient needs to be hospitalized for observation, therefore the medical staff with family members, by patient Ward is sent to move in.Since wound is at back, therefore patient needs to sleep on all fours, to coordinate the comfort level of patient, can use reinforcing bar Holder supports.Since the back wound after medication is covered with antiseptic gauze, is prevented in order to avoid the infection etc. of wound by summer The pollution of mosquitos and flies or other pollutants.After sprinkling drug, it is not necessarily to dressing.

It is observed after sprinkling drug one day, the pseudomembrane on back is gradually done but.At this time with cotton swab pressure, there is penetrating fluid exudation, uses Cotton swab penetrating fluid, while after disinfecting at penetrating fluid outflow, continuing to sprinkle the pharmaceutical composition in embodiment 3.It holds After 6-7 days continuous, it is found that pseudomembrane is done but, penetrating fluid tails off, and pseudomembrane is dry but.8-10 days or so, pseudomembrane was partly slit open, it can be seen that is had New meat is grown, and the 13-15 days or so, pseudomembrane all falls off, patient's recovery from illness, can leave hospital.

Later stage plays back, the new skin that patient's no sequel all goes well, and grows and original striking resemblances, indifference.

Clinical case 4

Slowly so-and-so, female, when Matches Factory does manual work, accidentally by dispensing gunpowder burns face, burn is attached most importance to II °, when burn occurs, is suffered from Person is in great pain.It first carries out disinfection debridement treatment to patient facial region, immediately after by the pharmaceutical composition in the embodiment of the present invention 2 It is spread on face, patient pain, which feels, to disappear, and visible pharmaceutical composition forms the pseudomembrane of moistening in face, spreads pesticides and 24 as a child saw It examines, it is found that pseudomembrane is dry but.Find there is the dry pseudomembrane but in part to split, and below place of splitting, it can be seen that have portion after 3-4 days New meat is divided to grow.After a week, the pseudomembrane done but all falls off, and face restores as before.Later stage plays back, patient's no sequel, all Normally, and the skin of face is no different with other area skins.

It is a in the prior art, the processing of debridement can be also carried out when burn and scald occurs, but after handling, still there is pain Sense, and by other treatments, feeling of pain will not disappear.

Clinical case 6

Mr. Li, male, 22 years old, cook.By fire wound face when cooking, attach most importance to II ° and light blister burn, when burn, pain is difficult Bear, there is blister.Sterilization debridement processing is first passed around, then cuts off blister.Pharmaceutical composition in the embodiment of the present invention 2 is applied It is spread on face, feeling of pain disappears, and drug hits liquid with oozing in blister and forms wet shape pseudomembrane.After three days, pseudomembrane have it is dry and cracked, and It is dry and cracked go out visible scarlet new skin grow.5 days or so, light blister burn restored completely；After a week, wet at weight blister burn Shape pseudomembrane falls off, and face restores as before.Without scar.

It is longer than light II ° of course for the treatment of by above-described embodiment it is found that II ° of weight is due to badly wounded, therefore when its treatment, recovery Slowly.

Application examples of the pharmaceutical composition in analgesic in the present invention：

Clinical case 1

Patient Zhao so-and-so, man, adult, accidentally by the boiling water burn of overturning hand tractor water tank, whole body is largely burned, and is arrived County Hospital diagnosis and treatment, patient pain unbearably, can not normal communication, medical staff can not cure in time, can not provide it is effective only Pain scheme can only on the ground be rolled about by family members or colleague come communication exchange.

It using the pharmaceutical composition in the embodiment of the present invention 3, is directly applied and is spread on the wound at patient injury position, suffered from Person's feeling of pain disappear, normally can be exchanged with people, ask its whether pain, patient answer, do not ache, and patient can stand, normally Walking, explains the situation with as medical staff, and medical staff describes and observes according to patient, is timely cured.Existing skill It in art, needs to take a large amount of anodyne, or even beat pain killer injection etc. mostly, effect is slow, and the alleviation of pain can only be for the moment , need patient's repeatedly drug administration repeatedly.

Clinical case 2

Mr. Wang, man, 28 years old, careless car to car impact by bus of going on business, by the boiling water burn whole body large area in automobile upper water box, pain Pain unbearably, can not normal speech, directly cry out pain.It using the pharmaceutical composition in the embodiment of the present invention 2, is spread at scald, is suffered from Person's feeling of pain is reduced, and after the completion of painting is spread, patient pain, which feels, to disappear, can be with partner treatment.

By using the pharmaceutical composition of the present invention so that patient pain disappears, and first, psychologically, no longer worries treatment The front and back feeling of pain to be endured；Secondly, patient pain, which feels, disappears, and medical staff facilitates processing wound, pain is avoided to lead to patient That can't help tampers, can not partner treatment.

Clinical case 3

Mr. Wang suffers from herpes zoster, has the herpes zoster purpling of side shoulder blade black and peels, area has palm a piece of greatly.This Illness leads to patient pain unbearably, can not coordinate the treatment of herpes zoster.Pharmaceutical composition in a small amount of embodiment 2 is spread on change The wound of black decortication, pain stop immediately, it is possible to coordinate medical treatment herpes zoster virus.Later stage through treatment, fully recovers after a week.

Clinical case 4

Mr. Wang needs to extract patient's nail cover, before excision, patient pain is unbearably, so closely linked with one's heart, therefore refers to because wound is squeezed Any treatment its pain degree on head is well imagined, in treatment, sprinkles the pharmaceutical composition of the present invention, in whole process, is suffered from Person fully recovers after a week without pain.

Application examples of the pharmaceutical composition in tumble injury in the present invention：

Clinical case 1

Mr. Wang, adult, man, by motorcycle when fall down accidentally, by tumble injury, patient pain unbearably, sees for knee and elbow It examines visible skin and flesh to have frayed, and has badly mutilated shape, there is the entrance of part sandstone.By hydrogen peroxide to knee and elbow Wound sterilize respectively after, the pharmaceutical composition in the embodiment of the present invention 2 is spread on wound, patient pain, which feels, to disappear；It simultaneously can Observe that pharmaceutical composition forms pseudomembrane on the surface of wound.

After one day, it is found that pseudomembrane is dry but, after 3-4 days, part pseudomembrane is dry and cracked, and dry and cracked ground can see having new meat long Go out.Due to there is the entrance such as sandstone, therefore when pseudomembrane falls off after a week, it is seen that sandstone with pseudomembrane is glutinous sticks together, wound is grown new Meat and other position indifferences, and without scar.

In the prior art, typically yellow ground item, tincture of iodine etc are treated, and in treatment, patient pain's sense does not subtract, cures Phase is generally even longer time two weeks, and during treatment, needs daily dressing, increases the economic expense of patient, and change daily Medicine need to bear the pain, and must spend the time.

The pharmaceutical composition of the present invention, compared with prior art, a drug is solved the problem once and for all, special effect, it is economical and It is all more saved than the prior art on time.

Clinical case 2

Mr. Wang, children, man fall down in concrete floor accidentally when playing, knee and face by tumble injury, have it is badly mutilated as. When tumble injury, because pain causes Mr. Wang to cry and shout always, family members' comfort is invalid.Medical staff first with hydrogen peroxide to its tumble injury position into It has gone disinfection, the pharmaceutical composition painting in the embodiment of the present invention 1 has then been spread on wound surface, Mr. Wang's crying stops, asking Its whether pain, answer do not ache.After sprinkling, it is seen that drug forms pseudomembrane in wound, is observed after one day, and pseudomembrane is dry but, and three It is observed after it, there is new meat to grow on dry pseudomembrane but.After 6 days, pseudomembrane falls off, and wound is replied as before.

Pharmaceutical composition in the present invention is more suitable for light II degree of burn and scald and head knead dough when being used for burn and scald II ° of burn and scald of weight in portion mainly avoids the excessive loss of internal body penetrating fluid, then passes through autosynthesis ability in treatment In conjunction with the common repairing and treating of this drug.And serious burn and scald is also coordinated just with powerful drug mostly with the presence of eschar It can radical cure.

Nowadays we to be said, III ° of large area, severe burn and scald are sent to large hospital or section hospital and specially controlled, It if to live is no better than to die very much by patient pain, can be used as interim pseudomembrane office envelope, stop pain, but his treatment to light Ⅱ° burn and scald Effectively.It is temporarily safe from harm to the above wound of light Ⅱ°, temporary office envelope, office sealed in 12 hours, will not cause severe burn and scald Any harm, it can stop pain（It can at least endure）, every aspect making contact cannot be blocked, also allows for nursing jointly It escorts and transports, but arrived after section hospital, can make people that light two degree or more wounds first be carried out dressing change, using him Special medicine treatment.The analgesic effect function of the pharmaceutical composition of the present invention is quite satisfied, and thus he can also be when anxious Cure uses.

The present invention smears drug without human hand etc., is directly spread on wound, avoids drug in use, external force is to wound Compressing, reduces feeling of pain.

The pharmaceutical composition of the present invention, is spread on any wound, can relieve pain immediately, for example cycles tumble injury, injures etc. and to draw Rise pain, sprinkle the present invention pharmaceutical composition after, analgesic effect is apparent, compared with the existing technology in analgesic drug product, only Pain speed is fast, good analgesic effect.Existing anodyne, either oral medicine or plastics after use, need a few minutes very Analgesic effect can be just played to a few houres, and analgesic time is limited, such as a few houres or 1 day etc..

The pharmaceutical composition of the present invention, when for burn and scald treatment, whole process is as follows：

When burn and scald occurs, pharmaceutical composition is spread on wound immediately, wound pain is prevented, meanwhile, powder of the invention is being created Hinder face oozed hit liquid liquefaction, form macroscopic micro-wet grey black pseudomembrane, in use, powder spread it is uniform shallow, due to The drug of the present invention is pulvis, therefore after it is spread on wound, drug can be inflated.

Or so 12 hours of scattering medication are applied, above-mentioned micro-wet grey black pseudomembrane is dry but.Since season and temperature influence, Generally Summer Dry but it is fast once, winter then does but slower.During doing but, oozing under pseudomembrane is hit liquid and is still being oozed It hits.After only thoroughly doing but, it could stop to ooze and hit, i.e., only interior environment reverse is positive at this time, repairs and stops extravasation, pseudomembrane gradually Nature can be done but without infiltration.

When applying third day after scattering medication and observing, is but hit without oozing if it find that wound surface is dry, illustrate that Nursing comparison is good, wound There is no collision again, hand to grab or other unexpected.Surprisingly the pseudomembrane on wound is caused to fall off if there is above-mentioned, then needed To sprinkle the pharmaceutical composition of the present invention again in time；As dried fruit but after still have and ooze strike waters pearl or a small amount of secretion on a small quantity Then object has secretion or oozes the place of pearl of striking waters and sprinkle the pharmaceutical composition of the present invention again then with dry cotton swab；For having Exposed wound, it is also desirable to sprinkle the pharmaceutical composition of the present invention.

For burn and scald, nursing is the key that in treatment, and nursing is proper, and wound is not collided again, then head Portion, face are fully recovered for general one week or so.Head and face, which occupy, belongs to sun, and lower subordinate is cloudy, and especially foot and leg is most cloudy, therefore Its recovery is slow, generally requires thorough decrustation recovery from illness in two weeks or so.

Observed within the 4th day after applying scattering medication, it is dry but to hit all right without oozing, but gently press it with cotton swab, see it is whether viscous but in fact If any fluctuation, then to prevent wound compromised internal from having purulence.The more tangible wound of adhesion, general to restore preferable, severe patient, Drug pseudomembrane is floated upper and is slided in purulence, needed carefully to nurse, avoided breaking wound.

It is observed within the 5th day after applying scattering medication, in addition to breathing, pulse, blood pressure and internal medicine, it is also necessary to observe psychiatric department etc., see Whether exception is had.For fire, floods, electric calamity and scaring person, more the more to observe.This special body due to people, therefore meeting There are many situations, such as diabetes, coronary heart disease, paediatrics and gynaecological disease etc., it is also desirable to which emphasis carries out clinical observation, avoids intentionally Outside.General 5th day, the dry line in part or crackle are had on pseudomembrane, while at the fine crack of dry line or crackle, it can be seen that fresh powder Red skin is grown, but then be can only see drug pseudomembrane for leg and foot etc. and done but, and dry line crackle etc. then needs to push away Several talentes grow afterwards, the time generally postponed half the time more late than face etc. or so.For example face is the 5th day, then leg foot is then It is the 8th day or so.

It is observed within the 6th day after applying scattering medication, 95% decrustation of head, lower limb about 5% are dry and cracked or whether decrustation wait or not.

The 6th day after painting scattering medication, all of the above decrustation of whole body head, foot and lower limb etc. then need 15 days or so, and the 7th It when, foot lower limb etc., drug pseudomembrane crackle tilting falls off, the visible tender skin of pink is grown under crackle, has taken off pseudomembrane portion Point, skin health skin is such as former.

After medication, basic daily observation is suited the remedy to the case, nursing is supreme comprehensively in conjunction with everyday points for attention above.95% with Upper light Ⅱ° once spreads pesticides, and is not necessarily to daily dressing or medication, it is only necessary in the wound that spreads pesticides by collsion damage or pseudomembrane by clashing and breaking When, apply again and spread, realizes repairing treatment.It in entire therapeutic process, varies with each individual, nursing fineness is different, therefore all It is different.Generally, most of to start to spread pesticides, a drug incrustation forms drug pseudomembrane, bad not fall, and then only needs arrive within one week Nursing in two weeks, you can recovery from illness.It is noted that the general five days left and right trunks in people top are but, decrustation in seven days or so is thoroughly gone out scar.And people Lower part, chest, abdomen, back, seven days or so dry and cracked, decrustation in two weeks or so；Lower limb dry and cracked, decrustation in 15 days or so in about 10 days or so.

The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that The specific implementation of the present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs, exist Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to the present invention's Protection domain.

Claims (8)

1. a kind of pharmaceutical composition, which is characterized in that including following raw material：Charred RADIX SANGUISORBAE, giant knotweed, Cortex Phellodendri and borneol.

2. a kind of pharmaceutical composition according to claim 1, which is characterized in that include the raw material of following quality parts ratio： 10-20 parts of 90-110 parts of charred RADIX SANGUISORBAE, 20-40 parts of giant knotweed, 20-40 parts of Cortex Phellodendri and borneol.

3. a kind of pharmaceutical composition according to claim 2, which is characterized in that include the raw material of following quality parts ratio： 15 parts of 100 parts of charred RADIX SANGUISORBAE, 30 parts of giant knotweed, 30 parts of Cortex Phellodendri and borneol.

4. according to a kind of application of any pharmaceutical compositions of claim 1-3, which is characterized in that described pharmaceutical composition It is preparing for treating the application in burn and scald medicine.

5. a kind of application of pharmaceutical composition according to claim 4, which is characterized in that described for treating burn-scald medicine Object refers to for treating light Ⅱ° burn and scald medicine and/or for treating depthⅡ° burn and scald medicine.

6. a kind of application of pharmaceutical composition according to claim 5, which is characterized in that described for treating depthⅡ° burning Scald medicament refers to the depthⅡ° burn and scald medicine for treating head and/or face.

7. according to a kind of application of any pharmaceutical compositions of claim 1-3, which is characterized in that described pharmaceutical composition Application in preparing analgesic drug product, the analgesic drug product are for the analgesic drug product in tumble injury, burn and treatment of scald.

8. according to a kind of application of any pharmaceutical compositions of claim 1-3, which is characterized in that described pharmaceutical composition It is preparing for treating the application in tumble injury drug.