CN106236900A - A kind of for compound medicine treating burn and preparation method thereof - Google Patents
A kind of for compound medicine treating burn and preparation method thereof Download PDFInfo
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- CN106236900A CN106236900A CN201610649824.0A CN201610649824A CN106236900A CN 106236900 A CN106236900 A CN 106236900A CN 201610649824 A CN201610649824 A CN 201610649824A CN 106236900 A CN106236900 A CN 106236900A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
Abstract
A kind of for compound medicine treating burn and preparation method thereof, this compound medicine being used for treating burn is mainly made up of crude drug, counts by weight, and crude drug includes: Os Draconis (calcined) 80～200 parts；Herba Andrographis 450～600 parts；Herba Taraxaci 400～550 parts；Cortex Phellodendri 360～500 parts；Rhizoma Chuanxiong 160～300 parts；Radix Saposhnikoviae 230～400 parts；Pedicellus Cucurbitae 350～450 parts；Willow root 410～580 parts；And Borneolum Syntheticum 20～50 parts.This compound medicine treats a second degree burn rapidly, and three to seven days the best, and does not stay scar.Cure third degree burn, not injury of the bone bone, burn wound healing, preventing and treating scar hyperplasia and pigmentation can be promoted simultaneously, after self falling, the most do not stay scar.The preparation method of this compound medicine, after crude drug ground and mixed；Also obtain compound medicine after crude drug can being ground with the reinforcing agent mixing placement such as vegetable oil, easy to operate simply, beneficially large-scale production.
Description
Technical field
The present invention relates to technical field of Chinese medicines, and particularly to a kind of compound medicine for treating burn and preparation side thereof
Method.
Background technology
Serious burn can bring greatly painful to people, injures human skin, affects the homergy function of the person.
Medical information data statistics according to authority, burn has reached 1.5%～2% at the sickness rate of China, there are about 2,000 ten thousand the most every year
People is burnt in various degree.
Burn doctor's nationality in ancient times is also called fire burn, burn and scald, burn etc., i.e. burn include fire burn, liquid scald and
Electric burn etc..The traditional Chinese medical science thinks that burn refers to that comburant and scorching hot liquid, solid, gas and electric current etc. directly act on human body,
Skin is caused to scald or burn, even fire-toxin inside fire attack internal organs.With injury redness causalgia, foaming, coking crust, accompany fever and irritability, mouth
Dry yellowish urine, even coma etc. are the damage class disease of main performance.Burn is all because of the heresy of fire-toxin, and wound Intradermal, notably pathogenic heat enters
In, fire-toxin is made a psychological attack, gas consumption impairment of YIN, makes impairment of both QI and YIN, imbalance of YIN and YANG, blockage of the vessel, and QI-blood circulation is not smooth, thermal burn nutrient blood, cloudy liquid
Consumed, skin losing its nutrition.
The degree of burn is divided into three degree clinically.I degree is burnt: for superficial burn, erythema, local skin redness heat occur
Bitterly, within general 3～5 days, can cure.II degree is burnt: shallow II degree is high dermis burn, and vesicle locally occurs, and bleb wall is thin, extremely
Edema, has severe pain, and bleb is broken forms rotten to the corn, incrustation, infects then recovery from illness in 7～11 days if there is not；Deep ii degree burn reaches corium deep layer,
Pain is slightly light, and vesicle is less, and bleb wall is thicker, has punctation, easily infect, general 3～4 in the micro-red or white skin lesion of substrate
Week healing, forms cicatrix, leaves pigmentation the most afterwards.III degree is burnt: depth of burn reaches skin holostrome or deeper, pallor
Or formation eschar, without pain.This kind of burn is difficult to spontaneous recovery, and after 2 weeks, eschar comes off formation granulation wound, forms atrophy after healing
Scars, often causes local deformity because cicatrix shrinks.
At present, the difficult point of burn treating mainly II degree and the preventing and treating of above burnt degree complication thereof, wound tissue are carried out
Property downright bad, secondary infection and patient's pigmentation, cicatrization etc..
Summary of the invention
The first object of the present invention is to provide a kind of compound medicine for treating burn, and this is for treating answering of burn
Side Drug therapy I degree burn can pain relieving rapidly, removing toxic substances Radix Saposhnikoviae, hemostasis convergence, scattered silt subside a swelling, prevent from festering and anti-inflammation.
Clinical instant effect and can prevent II degree and the complication of above burnt degree thereof, can make most fire victim tide over infection smoothly
Phase, burn wound healing can be promoted, prevent and treat scar hyperplasia and pigmentation, rear substantially without cicatrix.
The second object of the present invention is to provide the preparation method of a kind of compound medicine for treating burn, this preparation side
Method is simple, workable, on the premise of ensureing drug effect, it is easy to industrialized production.
The present invention solves it and technical problem is that and realize by the following technical solutions.
A kind of compound medicine for treating burn, is mainly made up of crude drug, counts by weight, and crude drug includes:
Os Draconis (calcined) 80～200 parts；Herba Andrographis 450～600 parts；Herba Taraxaci 400～550 parts；Cortex Phellodendri 360～500 parts；Rhizoma Chuanxiong
160～300 parts；Radix Saposhnikoviae 230～400 parts；Pedicellus Cucurbitae 350～450 parts；Willow root 410～580 parts and Borneolum Syntheticum 20～50 parts.
A kind of preparation method of the compound medicine for treating burn, by Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, Radix Saposhnikoviae,
Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) ground and mixed.
The preparation method of a kind of compound medicine for treating burn, puts after mixing with reinforcing agent after being ground by crude drug
Put.
Compared with prior art, the invention has the beneficial effects as follows:
1, this compound medicine follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", and wherein monarch drug is Os Draconis (calcined), Herba Andrographis and Pu
Herba Taraxaci；Ministerial drug is Rhizoma Chuanxiong, Radix Saposhnikoviae and Cortex Phellodendri；Adjuvant drug is Pedicellus Cucurbitae and willow root and Borneolum Syntheticum.Medicine composition in this compound medicine
It is main for being allocated as in order to heat-clearing and toxic substances removing, blood-activating and qi-promoting with convergence granulation promoting.Clinical drug safety, instant effect, treatment I degree and II degree burn
Rapidly, about seven days the best, and does not stay scar.Cure III degree burn, not injury of the bone bone, within about ten days, scab, burn wound can be promoted
Healing in face, after preventing and treating scar hyperplasia and pigmentation self falling, does not the most stay scar.
2, having effect of heat-clearing and toxic substances removing due to Herba Andrographis, Herba Taraxaci and Cortex Phellodendri, therefore this compound medicine antibacterial action is strong,
Need not add other preservative, it is not required that use with other Western medicine, particularly Antibiotic combination.This compound medicine is abided by simultaneously
Follow the principles of formulating prescriptions of the traditional Chinese medical science " incompatibility ", be the most substantially free from side effects.
3, crude drug Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, Radix Saposhnikoviae, Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) are all normal
The Chinese crude drug seen and be easy to get, therefore the selection of this medicament is simple and low cost, the on the other hand preparation method letter of this compound medicine
Single, Produce on a large scale can be carried out, have a extensive future.
4, the using method of this compound medicine is simple, it is not necessary to by operation, such as makes skin graft, treats cicatrix, do not affect
The daily routines of patient.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.In embodiment, unreceipted actual conditions person, builds according to normal condition or manufacturer
The condition of view is carried out.Agents useful for same or instrument unreceipted production firm person, being can be by the commercially available conventional product bought and obtain
Product.
Below a kind of of the embodiment of the present invention is carried out specifically for compound medicine treating burn and preparation method thereof
Bright.
A kind of compound medicine for treating burn that the embodiment of the present invention provides, this compound medicine is mainly by crude drug system
Becoming, count by weight, crude drug includes:
Os Draconis (calcined) 80～200 parts；Herba Andrographis 450～550 parts；Herba Taraxaci 450～550 parts；Cortex Phellodendri 350～450 parts；Rhizoma Chuanxiong
150～250 parts；Radix Saposhnikoviae 250～350 parts；Pedicellus Cucurbitae 350～450 parts；Willow root 450～550 parts；And Borneolum Syntheticum 30～50 parts.
Further, in present pre-ferred embodiments, counting by weight, crude drug includes: Os Draconis (calcined) 100～180
Part；Herba Andrographis 480～500 parts；Herba Taraxaci 450～550 parts；Cortex Phellodendri 400～450 parts；Rhizoma Chuanxiong 200～280 parts；Radix Saposhnikoviae 250～
380 parts；Pedicellus Cucurbitae 380～450 parts；Willow root 450～550 parts；And Borneolum Syntheticum 30～45 parts.Preferably, Os Draconis (calcined) is 100 parts,
Herba Andrographis is 500 parts, and Herba Taraxaci is 500 parts, and Cortex Phellodendri is 400 parts, and Rhizoma Chuanxiong is 200 parts, and Radix Saposhnikoviae is 300 parts, and Pedicellus Cucurbitae is 400
Part, willow root is 500 parts, and Borneolum Syntheticum is 40 parts.This compound medicine follows the traditional Chinese medical science " monarch " and the prescription of " incompatibility "
Principle, wherein monarch drug is Herba Andrographis, Herba Taraxaci and Cortex Phellodendri；Ministerial drug is Rhizoma Chuanxiong and Radix Saposhnikoviae；Adjuvant drug is Pedicellus Cucurbitae and willow root and ice
Sheet.The Main Function of the medicine group composition in this compound medicine includes heat-clearing and toxic substances removing, blood-activating and qi-promoting and convergence granulation promoting.
Os Draconis (calcined), has hemostasis, convergence and astringent or styptic treatment for spontaneous sweating effect, can make the ingredient breakdown such as calcium carbonate, calcium phosphate after calcine
For the oxide of calcium, calcium ion is readily absorbed by simultaneously, makes the content of calcium in blood increase, and calcium ion is coagulant, and calcium again may be used
Reduce the osmosis of blood vessel wall, reduce serum and penetrate into outside blood vessel wall.
Herba Andrographis, heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Most of pathogenic microorganisms are had the effect of suppression, has enhancing
The human leukocytes phagocytic activity to antibacterial, has antipyretic, antiinflammatory, and function of gallbladder promoting protects the liver, venom and muscarinic action.
Herba Taraxaci, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dampness removing is treating stranguria, and the medicinal ingredient in Herba Taraxaci has activated macrophage, anti-
Virus, excites the immunologic function of matrix.
Cortex Phellodendri, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency.There is the effect of resisting pathogenic microbes, to some dermatophytes also
Having inhibitory action, contained jateorhizine to have the formal muscular strength similar to berberine and antiarrhythmic effect, Cortex Phellodendri extract has
The effects such as pressurization, antiulcer, calmness, flesh pine, blood sugar lowering and promotion mouse antibodies generation.
Rhizoma Chuanxiong, blood-activating and qi-promoting, wind-expelling pain-stopping.Expansible blood vessel, reduces vascular resistance, dramatically increases brain and LBF
Amount, improves microcirculation, reduces surface activity of blood platelet, suppresses platelet aggregation, and the formation of pre-preventing thrombosis, to central nervous system
There is the effect of calmness, promote callus formation.
Radix Saposhnikoviae, expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
Pedicellus Cucurbitae, removing toxic substances, diuretic, pulls out pyretic toxicity layman.
Willow root, removing heat from blood, hemostasis, sore of detoxifying.
Borneolum Syntheticum, erosion prevention and muscle growing, clearing heat for detumescence, promoting tissue regeneration and ulcer healing, local uses has minimal irritation to sensory nerve, has certain
Pain relieving and gentle antisepsis.
Present invention also offers the preparation method of compound medicine of above-mentioned treatment burn, by Herba Andrographis, Herba Taraxaci, Cortex Phellodendri,
Rhizoma Chuanxiong, Radix Saposhnikoviae, Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) obtain compound medicine after grinding.This preparation method is simple to operate, stream
Journey is controlled, is suitable for large-scale production.
Further, in present pre-ferred embodiments, also including reinforcing agent, reinforcing agent includes vegetable oil, Mel, glycerol
And any one in Aloe glue.Vegetable oil, Mel, glycerol and Aloe glue can make wound healing.Wherein vegetable oil is to soft
Change blood vessel and keep blood vessel elasticity all to have preferable effect, greasy skin and rich in vitamin E, being conducive to maintaining cell membrane
Complete and function is normal.Preferably, any one during vegetable oil is Oleum sesami, soybean oil, olive oil and Oleum Brassicae campestris.Wherein, sesame
Oleum Sesami has fragrance, can play the effect invigorated blood circulation.
Further, in present pre-ferred embodiments, the weight of reinforcing agent and the ratio of crude drug gross weight be: 0.54～
0.70:1.Preferably, reinforcing agent is vegetable oil, and a kind of compound medicine for treating burn, by weight, including vegetable oil
1500～2000 parts；Os Draconis (calcined) 80～200 parts；Herba Andrographis 450～600 parts；Herba Taraxaci 400～550 parts；Cortex Phellodendri 360～500
Part；Rhizoma Chuanxiong 160～300 parts；Radix Saposhnikoviae 230～400 parts；Pedicellus Cucurbitae 350～450 parts；Willow root 410～580 parts；And Borneolum Syntheticum 20～
50 parts.
Present invention also offers the preparation method of the compound medicine of above-mentioned treatment burn, with reinforcing agent after being ground by crude drug
Place after mixing.Preferably, the time placed after the crude drug after grinding mixes with reinforcing agent is at least 7 days.By crude drug with
After reinforcing agent mixing is placed, the effective ingredient in each crude drug can be dispersed in reinforcing agent, can fast onset curative effect.
Further, in present pre-ferred embodiments, before crude drug mixes placement with reinforcing agent, also include that parch is worn
Heart lotus, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, Radix Saposhnikoviae, Pedicellus Cucurbitae, willow root and Os Draconis (calcined).Through the crude drug of parch, there is releasing fire-toxin
Curative effect.Preferably, by Os Draconis (calcined), Pedicellus Cucurbitae, Cortex Phellodendri and willow root parch to black, Herba Andrographis, Radix Saposhnikoviae, Herba Taraxaci and Rhizoma Chuanxiong are fried
Yellow.
Further, in present pre-ferred embodiments, the medicament of compound medicine be unguentum, oil preparation, spray, membrane,
Powder or decoction.
In inventive embodiment, outside dosage form unguentum, oil preparation, spray, membrane, powder and the decoction of compound medicine is
With preparation, there is no the first pass effect of liver, directly the burned part of patient is played therapeutical effect.Also prevent in having taken simultaneously
In medicine, there is the situation of side effect in some compositions mixed.Wherein, the using method of decoction can be by the decoction of compound medicine
It is coated directly on the wound of patient to reach the purpose of sterilization and treatment.
In inventive embodiments, when using quintessence oil and medicinal ointment therapy burn, wound surface can be allowed to keep moisture state, promote wound
Face rawhide voluntarily, put on flesh, reach the purpose of self-service healing, shorten healing time.
The compound medicine of the treatment burn that the present invention provides has the curative effect of heat-clearing and toxic substances removing, blood-activating and qi-promoting and convergence granulation promoting；
Rapidly, three to seven days the best, and does not stay scar for treatment I degree and II degree burn.Cure III degree to burn, not injury of the bone bone, about ten days
Scab；Burn wound healing can be promoted simultaneously, after preventing and treating scar hyperplasia and pigmentation self falling, the most do not stay scar.
Below in conjunction with embodiment, inventive feature and performance are described in further detail.
Embodiment 1
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug.Crude drug
Including: Herba Andrographis 450g, Herba Taraxaci 450g, Cortex Phellodendri 450g, Rhizoma Chuanxiong 280g, Radix Saposhnikoviae 250g, Pedicellus Cucurbitae 350g, willow root 410g,
Borneolum Syntheticum 20g, and Os Draconis (calcined) 120g.
A kind of preparation method for treating burn compound medicine: above-mentioned raw materials medicine ground and mixed is uniformly obtained compound medicines
Thing.This compound medicine is made powder use.
Embodiment 2
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug.Crude drug
Including: Herba Andrographis 600g, Herba Taraxaci 550g, Cortex Phellodendri 480g, Rhizoma Chuanxiong 300g, Radix Saposhnikoviae 380g, Pedicellus Cucurbitae 450g, willow root 580g,
Borneolum Syntheticum 50g, and Os Draconis (calcined) 180g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
This compound medicine is obtained with Borneolum Syntheticum mixed grinding Cheng Fenhou after wind, Pedicellus Cucurbitae, willow root and Os Draconis (calcined) parch.By this compound medicine
Make film former to use.
Embodiment 3
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug.Crude drug
Including: Herba Andrographis 480g, Herba Taraxaci 400g, Cortex Phellodendri 360g, Rhizoma Chuanxiong 160g, Radix Saposhnikoviae 230g, Pedicellus Cucurbitae 380g, willow root 450g,
Borneolum Syntheticum 30g, and Os Draconis (calcined) 80g.
A kind of for treat burn compound medicine preparation method: above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, Radix Saposhnikoviae,
This compound medicine is obtained after Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) ground and mixed.This compound medicine is made boiling hot agent use.
Embodiment 4
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug.Crude drug
Including: Herba Andrographis 550g, Herba Taraxaci 480g, Cortex Phellodendri 500g, Rhizoma Chuanxiong 250g, Radix Saposhnikoviae 400g, Pedicellus Cucurbitae 450g, willow root 550g,
Borneolum Syntheticum 45g and Os Draconis (calcined) 200g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
This compound medicine is obtained after wind, Pedicellus Cucurbitae, willow root, Os Draconis (calcined) and borneol and grinding mixing.This compound medicine is done film former make
With.
Embodiment 5
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug.Crude drug
Including: Herba Andrographis 500g, Herba Taraxaci 500g, Cortex Phellodendri 400g, Rhizoma Chuanxiong 200g, Radix Saposhnikoviae 300g, Pedicellus Cucurbitae 400g, willow root 500g,
Borneolum Syntheticum 40g, and Os Draconis (calcined) 100g.
A kind of preparation method for treating burn compound medicine: above-mentioned Os Draconis (calcined), Pedicellus Cucurbitae, Cortex Phellodendri and willow root are fried
Charcoal, after Herba Andrographis, Herba Taraxaci, Rhizoma Chuanxiong and Radix Saposhnikoviae parching to brown, becomes powder to obtain compound medicine with Borneolum Syntheticum mixed grinding.By this compound medicines
Thing does paste making agent and uses.
Embodiment 6
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 450g, Herba Taraxaci 450g, Cortex Phellodendri 450g, Rhizoma Chuanxiong 280g, Radix Saposhnikoviae 250g, Pedicellus Cucurbitae 350g, willow
Tree root 410g, Borneolum Syntheticum 20g, and Os Draconis (calcined) 120g.Reinforcing agent is Oleum sesami 1500g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Os Draconis (calcined), Pedicellus Cucurbitae, Cortex Phellodendri, Herba Andrographis, Pu
Add Oleum sesami mixing after mixing with borneol and grinding after Herba Taraxaci, Rhizoma Chuanxiong and Radix Saposhnikoviae parch to soak 20 days, take filtrate after filtration and obtain
The quintessence oil of compound medicine.
Embodiment 7
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 480g, Herba Taraxaci 400g, Cortex Phellodendri 360g, Rhizoma Chuanxiong 160g, Radix Saposhnikoviae 230g, Pedicellus Cucurbitae 380g, willow
Tree root 450g, Borneolum Syntheticum 30g and Os Draconis (calcined) 80g.Reinforcing agent is soybean oil 1800g.
A kind of for treat burn compound medicine preparation method: above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, Radix Saposhnikoviae,
Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) add immersion in soybean oil and obtain compound medicine in 7 days after grinding.Compound medicine is done
Ointment is become to use.
Embodiment 8
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 500g, Herba Taraxaci 500g, Cortex Phellodendri 400g, Rhizoma Chuanxiong 200g, Radix Saposhnikoviae 300g, Pedicellus Cucurbitae 400g, willow
Tree root 500g, Borneolum Syntheticum 40g and Os Draconis (calcined) 100g.Reinforcing agent is Oleum sesami 2000g.
A kind of preparation method for treating burn compound medicine: above-mentioned Os Draconis (calcined), Pedicellus Cucurbitae, Cortex Phellodendri and willow root are fried
Charcoal, by after Herba Andrographis, Herba Taraxaci, Rhizoma Chuanxiong and Radix Saposhnikoviae parching to brown with Borneolum Syntheticum mixed grinding Cheng Fenhou, be eventually adding in Oleum sesami encapsulation
Place and soak 20 days, cross leaching filtrate and obtain compound medicine quintessence oil.
Embodiment 9
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 550g, Herba Taraxaci 480g, Cortex Phellodendri 500g, Rhizoma Chuanxiong 250g, Radix Saposhnikoviae 400g, Pedicellus Cucurbitae 450g, willow
Tree root 550g, Borneolum Syntheticum 45g and Os Draconis (calcined) 200g.Reinforcing agent is soybean oil 2200g.
A kind of preparation method for treating burn compound medicine: above-mentioned Os Draconis (calcined), Pedicellus Cucurbitae, Cortex Phellodendri and willow root are fried
Charcoal, by after Herba Andrographis, Herba Taraxaci, Rhizoma Chuanxiong and Radix Saposhnikoviae parching to brown with Borneolum Syntheticum mixed grinding Cheng Fenhou, be eventually adding in soybean oil encapsulation,
Place and soak 12 days, filter, take filtering residue and obtain the ointment of compound medicine.
Embodiment 10
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 600g, Herba Taraxaci 550g, Cortex Phellodendri 480g, Rhizoma Chuanxiong 300g, Radix Saposhnikoviae 380g, Pedicellus Cucurbitae 450g, willow
Tree root 580g, Borneolum Syntheticum 50g and Os Draconis (calcined) 180g.Reinforcing agent is Oleum Brassicae campestris 2500g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
Become powder with borneol and grinding after wind, Pedicellus Cucurbitae, willow root and Os Draconis (calcined) parch, be eventually adding in Oleum Brassicae campestris encapsulation, place immersion 16
My god, filter, take filtering residue and obtain the ointment of compound medicine.
Embodiment 11
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 580g, Herba Taraxaci 520g, Cortex Phellodendri 440g, Rhizoma Chuanxiong 260g, Radix Saposhnikoviae 280g, Pedicellus Cucurbitae 380g, willow
Tree root 460g, Borneolum Syntheticum 35g and Os Draconis (calcined) 140g.Reinforcing agent is Mel 2100g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
Become powder with borneol and grinding after wind, Pedicellus Cucurbitae, willow root and Os Draconis (calcined) parch, be eventually adding in Mel immersion and obtain compound medicines in 16 days
Thing.This compound medicine is made ointment use.
Embodiment 12
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 520g, Herba Taraxaci 510g, Cortex Phellodendri 380g, Rhizoma Chuanxiong 180g, Radix Saposhnikoviae 290g, Pedicellus Cucurbitae 370g, willow
Tree root 450g, Borneolum Syntheticum 40g and Os Draconis (calcined) 110g.Reinforcing agent is glycerol 2100g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
Wind, Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) add immersion in glycerol and obtain compound medicine in 18 days after pulverizing.By compound recipe
Medicine is made quintessence oil and is used.
Embodiment 13
The present embodiment provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 560g, Herba Taraxaci 500g, Cortex Phellodendri 480g, Rhizoma Chuanxiong 280g, Radix Saposhnikoviae 380g, Pedicellus Cucurbitae 400g, willow
Tree root 500g, Borneolum Syntheticum 42g and Os Draconis (calcined) 150g.Reinforcing agent is Aloe glue 2150g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
Wind, Pedicellus Cucurbitae, willow root, Borneolum Syntheticum and Os Draconis (calcined) ground and mixed；Then the crude drug parch after grinding, is eventually adding Aloe
Glue mixing is placed and is obtained compound medicine in 18 days.Compound medicine is made ointment use.
Embodiment 14
The present embodiment 14 provides a kind of compound medicine for treating burn, and this compound medicine is by crude drug and reinforcing agent system
Become.Crude drug includes: Herba Andrographis 500g, Herba Taraxaci 500g, Cortex Phellodendri 400g, Rhizoma Chuanxiong 200g, Radix Saposhnikoviae 300g, Pedicellus Cucurbitae 400g, willow
Tree root 500g, Borneolum Syntheticum 40g and Os Draconis (calcined) 100g.Reinforcing agent is Oleum sesami 2000g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
With borneol and grinding after wind, Pedicellus Cucurbitae, willow root and Os Draconis (calcined) parch, it is eventually adding in Oleum sesami placement and obtains compound medicine in 5 days.
This compound medicine is made quintessence oil use.
Comparative example 1
This comparative example 1 provides a kind of compound medicine for treating burn, and this compound medicine is made up of crude drug, crude drug
Including: Herba Andrographis 550g, Herba Taraxaci 480g, Cortex Phellodendri 500g, Rhizoma Chuanxiong 250g, Radix Saposhnikoviae 400g, Pedicellus Cucurbitae 450g, willow root 550g and
Borneolum Syntheticum 45g.
A kind of preparation method for treating burn compound medicine: by above-mentioned Herba Andrographis, Herba Taraxaci, Cortex Phellodendri, Rhizoma Chuanxiong, prevent
This compound medicine is obtained after wind, Pedicellus Cucurbitae, willow root and borneol and grinding.This compound medicine is made powder use.
Comparative example 2
A kind of medicine treating burn, has the raw material of following weight proportioning to make: Cortex Jujubae 150g, Cortex ulmi pumilae 160g, Chinese toon
Root bark 160g, Cortex Phellodendri 200g, Radix Sanguisorbae 250g, Rhizoma Polygoni Cuspidati 220g, Borneolum Syntheticum 100g.By Cortex Jujubae, Cortex ulmi pumilae, Cortex Ailanthi, Cortex Phellodendri,
Elm, Rhizoma Polygoni Cuspidati the most proportionally prepare, then are processed into coarse powder by traditional Chinese medical science traditional handicraft, put into pottery or glass container；With
Coarse powder is uniformly soaked by the ethanol of 75%, at interval of 12-24 hour, stirs with waddy, is beneficial to the maximum of ingredient
Changing and separate out, spring and autumn soaks 5 days, 4 days summers, 9 days winters；By percolation filter add Borneolum Syntheticum Burn Tincture.
Test example
One, testing program
1. case selection
Through 208 example fire victim's clinical trials, the oldest person 70 years old, reckling 6 months, patient's degree of burning differs,
Wherein I degree is burnt 64 examples, II degree 80 example, III degree 64 example.
2. therapeutic scheme
After the burned part cleaning of patient, sterilization, smear embodiment 1～14 and wrap after the compound medicine of comparative example 1～2
Prick, for I degree fire victim, use every day twice, use 5 continuously.II degree patient is coated with twice every day, uses 7 continuously.Right
It is coated with every day three times in III degree patient, uses 10 continuously.
Selected case is divided into 16 groups, and often group has 4 I degree fire victims, 5 II degree fire victims, 4 III burns
Patient.The often the most corresponding embodiment of group or a comparative example.Therefore I degree burn can do 4 groups repeat test, II degree burn can
Doing 5 groups and repeat test, III degree burn can do 4 groups of repetitions.
3. the standard of curative effect evaluation
" the burn health published according to burn surgery branch of Chinese Medical Association, Department of B urn doctor branch of doctors'associations of China
Multiple treatment guidelines (2013 editions) " indicate, evaluation index index and method for burn rehabilitation have:
(1) each group of patient wound's scab forming time and wound healing time are observed, and by wound scab forming time and wound healing
Time is recorded in Tables 1 and 2 respectively.
(2) Barthel index, Functional outcome scale is used to carry out giving a mark and by call in table 3, then
According to following standards of grading evaluation patient's activity of daily living.
Standards of grading: best result 100 points.
> 60 points: good, life is basic takes care of oneself；
41～60 points: moderate disability, daily life wants help；
21～40 points: severe disability, daily life substantially relies on；
≤ 20 points: completely disabled, daily life is completely dependent on.
(3) use Vancouver scar scale that the patient after treatment is given a mark and by call in table 4, then root
Standards of grading are descended to evaluate cicatrix according to this.
Standards of grading: best result 15 points, minimum point 0 point, mark the highest explanation cicatrix is the most serious, otherwise, the gentliest.
4. statistical method
Often organize and take the meansigma methods that I degree, II degree and III degree burn repeat to test respectively.
Two, result of the test
Table 1. patient wound's scab forming time
Table 2. patient wound's healing time
Activity of daily living Score Lists after table 3. treatment
Vancouver scar scale after table 4. treatment
As can be seen from Table 1 and Table 2: embodiment 1～14 compared with comparative example 1, the wound of the patient of comparative example 1 correspondence
Healing time is longer, adds Os Draconis (calcined) mainly due to embodiment 1～14, correspondingly the compound medicine of embodiment 1～14 preparation
Drug effect more preferable.The wound incrustation of the patient of embodiment 6～14 correspondence is more shorter than the time of embodiment 1～5 with the time of healing
Some, be primarily due to embodiment 6～14 and add reinforcing agent.
As known from Table 3: patient's activity of daily living score of embodiment 1～14 correspondence is than the patient of comparative example 1～2 correspondence
Score is high, and score value is the highest, and the activity of daily living of patient is the strongest, illustrate that embodiment 1～14 provides for treating burn
The therapeutic effect of compound medicine more preferable.
By table 4 it can be seen that use embodiment 1～14 provide for treat burn compound medicine treatment I degree and
II degree burn treating is effective, and the score of Vancouver scar scale is relatively low, and score value is the lowest, illustrates that cicatrix is the lightest, particularly implements
Patient's score value of example 8 correspondence is minimum, does not stay scar.Wherein, the score comparison ratio of the III degree fire victim of embodiment 1～14 correspondence
The score of the III degree fire victim of example 1～2 correspondence is the least, and the compound recipe for treating burn that embodiment 1～14 provides is described
Drug therapy III degree burn treating effect is notable.
Data from table 1 to table 4 can obtain: the compound medicine being used for treating burn using embodiment 6～13 to provide is controlled
Treat the better efficacy of the compound medicine that the effect of various degrees of fire victim provides than embodiment 14, mainly due to embodiment
6～13 times placed when preparing compound medicine are more long.Secondly as embodiment 7 had not both had parch crude drug yet
Not pulverizing, therefore the curative effect of compound medicine is poorer than other embodiments；Embodiment 9 when preparing compound medicine, by
In not pulverizing, the curative effect of medicine is going up to a certain extent, is affected, and the time therefore healed is longer, treatment effect
The most poor.Embodiment 12 does not has parch step, and wound healing time is the most long with the time of incrustation, activity of daily living score
Relatively low, Vancouver scar scale score is high, therefore corresponding weak curative effect；Embodiment 13 is first to grind parch after crude drug, medicine
That grinds after imitating parch more first than embodiment 8 is more slightly worse.
It is the most all that the drug effect that obtains of embodiment 8 is best, mainly due to the compound medicine of embodiment 8 in preparation process
In, by the parch respectively of different for property of medicine crude drug to after in various degree, then to pulverize, the time simultaneously placed is a little longer, institute
Best with the drug effect that finally obtains.
Model case 1
2007, the Wang of 32 years old, the steamed bun severe scald just taken the dish out of the pot by a pot, the skin of 50% was all one's water breaks bubble.Pain
Pain unbearably, is not being cleaned, the compound medicines of the direct treatment burn using the embodiment of the present invention 8 to provide in the case of not having wrapping
The quintessence oil of thing, pain relieving after half an hour.Smear one day after twice, after 4 days blister disappear.Form a scab after 6 days, recovery from illness.
Model case 2
2012, Chen, spattered in head, face, abdominal part by molten iron, sulphuric acid.III degree is burnt, in Yuhuan the People's Hospital
Do not fully recover after treating one month.The quintessence oil of the compound medicine that the treatment using the embodiment of the present invention 8 to provide afterwards is burnt, half an hour
Rear pain relieving.Smear one day after twice, hold back water after 3 days, red and swollen disappear, form a scab after 7 days, fully recover after one month.
Model case 3
In December, 2014, the boiled blast of water, Lee's wrist to finger rats after severe scald burn, there is not treatment at hospital admission yet after 8 days
Effect, inflammation reaches III degree, and hands skin all comes off, and skin surface is red and swollen, and the embodiment 8 using the present invention to provide is used for treating burn
Compound essential Oil after 4 days slough come off, seven days recovery from illness, do not leave over cicatrix.
Model case 4
In June, 2016, field, 55 years old, people from Hubei, to be scalded by the boiled water of pressure cooker, III degree, hospital treatment did not had after 8 days
Have bigger improvement, smear the embodiment of the present invention 9 provide after the composite medical ointment treating burn, after 13 days fully recover, without scar
Trace.
Model case 5
Liu, 23 years old, people from Anhui, in evening on June 28th, 2016, lower limb is burned, and left foot II degree is scalded, and right crus of diaphragm III degree is scalded,
Hurt like hell, directly smear that the embodiment of the present invention 9 provides after the composite medical ointment treating burn, be coated with twice every day, seven days
Incrustation, detumescence, recovery from illness in 10 days, without cicatrix.
Model case 6
Poplar, 5 years old, on July 23rd, 2016, scalds and reaches more than deep II level, and facial skin more than 40% is burned, and works as angel
With the embodiment of the present invention 8 provide after treating the compound essential Oil of burn, facial skin is not got blister, and fully recovers after one week,
Without cicatrix.
Embodiments described above is a part of embodiment of the present invention rather than whole embodiments.The reality of the present invention
The detailed description executing example is not intended to limit the scope of claimed invention, but is merely representative of the selected enforcement of the present invention
Example.Based on the embodiment in the present invention, those of ordinary skill in the art are obtained under not making creative work premise
Every other embodiment, broadly falls into the scope of protection of the invention.
Claims (10)
1. the compound medicine being used for treating burn, it is characterised in that be mainly made up of crude drug, count by weight, institute
State crude drug to include:
Os Draconis (calcined) 80～200 parts；Herba Andrographis 450～600 parts；Herba Taraxaci 400～550 parts；Cortex Phellodendri 360～500 parts；Rhizoma Chuanxiong 160
～300 parts；Radix Saposhnikoviae 230～400 parts；Pedicellus Cucurbitae 350～450 parts；Willow root 410～580 parts；And Borneolum Syntheticum 20～50 parts.
Compound medicine for treating burn the most according to claim 1, it is characterised in that count by weight, described
Crude drug includes:
Described Os Draconis (calcined) 100～180 parts；Described Herba Andrographis 480～550 parts；Described Herba Taraxaci 450～550 parts；Described Cortex Phellodendri
400～450 parts；Described Rhizoma Chuanxiong 200～280 parts；Described Radix Saposhnikoviae 250～380 parts；Described Pedicellus Cucurbitae 380～450 parts；Described willow
Tree root 450～550 parts；And described Borneolum Syntheticum 30～45 parts；Preferably, described Os Draconis (calcined) is 100 parts, and described Herba Andrographis is 500 parts,
Described Herba Taraxaci is 500 parts, and described Cortex Phellodendri is 400 parts, and described Rhizoma Chuanxiong is 200 parts, and described Radix Saposhnikoviae is 300 parts, described Pedicellus Cucurbitae
Being 400 parts, described willow root is 500 parts, and described Borneolum Syntheticum is 40 parts.
Compound medicine for treating burn the most according to claim 1, it is characterised in that described for treating burn
Compound medicine also includes that reinforcing agent, described reinforcing agent include any one in vegetable oil, Mel, glycerol and Aloe glue.
Compound medicine for treating burn the most according to claim 3, it is characterised in that the weight of described reinforcing agent with
The ratio of described crude drug gross weight is: 0.54～0.70:1.
Compound medicine for treating burn the most according to claim 4, it is characterised in that by weight, including: institute
State vegetable oil 1500～2000 parts；Described Os Draconis (calcined) 80～200 parts；Described Herba Andrographis 450～600 parts；Described Herba Taraxaci 400～
550 parts；Described Cortex Phellodendri 360～500 parts；Described Rhizoma Chuanxiong 160～300 parts；Described Radix Saposhnikoviae 230～400 parts；Described Pedicellus Cucurbitae 350
～450 parts；Described willow root 410～580 parts；And described Borneolum Syntheticum 20～50 parts.
Compound medicine for treating burn the most according to claim 3, it is characterised in that described vegetable oil is Semen Sesami
Any one in oil, soybean oil or Oleum Brassicae campestris；Preferably, described vegetable oil is Oleum sesami.
The preparation method of the compound medicine for treating burn the most according to claim 1, it is characterised in that wear described
Heart lotus, described Herba Taraxaci, described Cortex Phellodendri, described Rhizoma Chuanxiong, described Radix Saposhnikoviae, described Pedicellus Cucurbitae, described willow root, described Borneolum Syntheticum and institute
State Os Draconis (calcined) ground and mixed.
The preparation method of the compound medicine for treating burn the most according to claim 3, it is characterised in that by described former
Material medicine is placed after mixing with described reinforcing agent after grinding；Preferably, after the described crude drug after grinding mixes with described reinforcing agent
The time placed is at least 7 days.
The preparation method of the compound medicine for treating burn the most according to claim 8, it is characterised in that by described
Crude drug also include before mixing with described reinforcing agent Herba Andrographis described in parch, described Herba Taraxaci, described Cortex Phellodendri, described Rhizoma Chuanxiong,
Described Radix Saposhnikoviae, described Pedicellus Cucurbitae, described willow root and the step of described Os Draconis (calcined).
The preparation method of the compound medicine for treating burn the most according to claim 9, it is characterised in that by described
Os Draconis (calcined), described Pedicellus Cucurbitae, described Cortex Phellodendri and described willow root parch to black, by described Herba Andrographis, described Radix Saposhnikoviae, described Herba Taraxaci and
Described Rhizoma Chuanxiong parching to brown.
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| CN112138064A (en) * | 2020-09-23 | 2020-12-29 | 广东颂德制药有限公司 | Wound burn antibacterial cream and processing method thereof |
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Application publication date: 20161221 |
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| RJ01 | Rejection of invention patent application after publication |