CN103055260A - Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof Download PDFInfo
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- CN103055260A CN103055260A CN2012105907251A CN201210590725A CN103055260A CN 103055260 A CN103055260 A CN 103055260A CN 2012105907251 A CN2012105907251 A CN 2012105907251A CN 201210590725 A CN201210590725 A CN 201210590725A CN 103055260 A CN103055260 A CN 103055260A
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Abstract
The invention provides a traditional Chinese medicine composition for treating ulcerative colitis, and a preparation method thereof. The composition of the traditional Chinese medicine for treating ulcerative colitis is prepared by mixing the components in parts by weight as follows: 10-30 parts of chrysanthemum, 15-25 parts of pericarpium citri reticulatae, 10-30 parts of radix curcumae, 10-30 parts of hawthorn, 5-15 parts of liquorice, 15-25 parts of fructus amomi, 20-40 parts of endoconcha sepiae, 5-10 parts of coptis chinensis, 2-8 parts of gizzard pepsin, 15-25 parts of mangnolia officinalis, 30-50 parts of Chinese-date flesh, 10-20 parts of bletilla striata, 20-30 parts of rhizoma corydalis and 25-35 parts of propolis. The composition of the traditional Chinese medicine has the benefits that the composition is reasonable; a synergistic effect of every component is achieved; the composition of the traditional Chinese medicine has the functions of clearing away heat, drying dampness, tonifying spleen, nourishing stomach and the like, is good in curative effect, can take effect quickly and achieve the effect of treating both symptoms and root causes, and can be prepared easily; the components can be mixed more uniformly step by step; the composition of the pure traditional Chinese medicine is free from pollution, drug residues and drug resistance, low in cost, wide in material drawing range, high in availability and remarkable in curative effect; and superfine grinding is achieved.
Description
Technical field
The present invention relates to Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of ulcerative colitis.
Background technology
The symptom of ulcerative colitis mainly contains: diarrhoea, hemafecia, stomachache and intestinal show outward.More and more serious when the inflammatory reaction of intestinal wall internal layer, and when forming ulcer, it has just lost the function that absorbs moisture from food debris.Correspondingly, will cause feces more and more looser---in other words, be exactly diarrhoea.Impaired intestinal mucosa also can cause Mucous Stool.Simultaneously, the ulcer of mucous layer also can cause bleeding, and therefore produces hemafecia.In fact, losing blood of continuing can cause anemia.Most patients of ulcerative colitis may have the defecation sense of urgency and abdominal colic, and this pain may be take the left side as main, because the colon hypomere is positioned at the left side.Diarrhoea and stomachache may cause the decline of poor appetite and body weight, and these symptoms also can cause tired, and this equally also is one of side effect of anemia.The child patient of ulcerative colitis may affect growth promoter.There have the patient of 8～10 years medical histories of ulcerative colitis to get the colon cancer risk to be higher.
At present, ulcerative colitis does not have effect method, and the most frequently used drug main will be divided into following a few class:
Salicylates: what this class medicine was the most cheap is sulfasalazine, need the help of human body intestinal bacterium just can be decomposed into 5-aminosalicylic acid performance therapeutical effect after oral, but the another kind of pharmaceutical compositions sulfapyridine that decomposes then may have infringement to liver, therefore the patient who takes such medicine does not take antibiotic at last, and make regular check on per month liver function (transaminase) simultaneously.
Glucocorticoid: this class medicine mainly contains the oral formulations prednisone, but the patient with severe symptoms also short-term use intravenous formulations.Because its side effect is more, do not recommend as growing course of therapy or keeping treatment.
Immunomodulator: this class medicine comprises azathioprine, Ismipur (6-MP), ciclosporin.The continuation development that medicine controls inflammation by the immune system that suppresses body.Immunomodulator is applicable to those para-aminosalicylic acid class medicines and glucocorticoid uses invalid or the effective patient of part, also is to keep at present one of best medicine for the treatment of.It also can be used for alleviating or eliminates the patient to the dependence of glucocorticoid.When the patient was reactionless to other drug, it may work to the alleviation of keeping disease.But such medicine is generally taken and is begun onset about March, and some patients were is prone to leucocytes reduction.
If the untimely healing of this disease not only can affect patient's routine work study, and brings great misery can for the patient, cause white elephant for family, society.The medicine of some analgesic effect can only take stopgap measures and can not effect a permanent cure, pain relief after the medication, but can recur again after the drug withdrawal, repeatedly medication forms Drug resistance, obstinate easily.
Summary of the invention
In order to remedy the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition of effective treatment ulcerative colitis.
Concrete scheme is as follows: 1, a kind of Chinese medicine composition for the treatment of ulcerative colitis, by following component by weight mixed preparing form: Flos Chrysanthemi 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Radix Curcumae 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 5-15 part, Fructus Amomi 15-25 part, extra large Piao sheath 20-40 part, Rhizoma Coptidis 5-15 part, Endothelium Corneum Gigeriae Galli 2-8 part, Cortex Magnoliae Officinalis 15-25 part, Fructus Jujubae 30-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Rhizoma Corydalis 20-30 part, propolis 25-35 part.
On the basis of such scheme, the present composition preferably by following component by weight mixed preparing form: 20 parts of Flos Chrysanthemis, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Radix Curcumaes, 20 parts of Fructus Crataegis, 10 parts in Radix Glycyrrhizae, 20 parts of Fructus Amomis, 30 parts in extra large Piao sheath, 10 parts of Rhizoma Coptidis, 5 parts of Endothelium Corneum Gigeriae Galli, 20 parts of Cortex Magnoliae Officinalis, 40 parts of Fructus Jujubae, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 25 parts of Rhizoma Corydalis, 30 parts of propolis.
The raw material that the present invention adopts as follows with performance evaluation:
Flos Chrysanthemi: heat-clearing and toxic substances removing, dispelling wind and heat pathogens, summer-heat removing, the pathogenic fire reducing sore-throat relieving, promoting the production of body fluid to quench thirst is removed anemopyretic cold, warm blood fulminant dysentery, the swollen furuncle of pain, the effects such as epidemic febrile disease heating;
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly that poor appetite, stomachache, tripe expand, have loose bowels, productive cough due to phlegm-damp etc.
Radix Curcumae: bitter, hot, cold, return lung, liver, heart channel, have the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, pure and fresh removing heat from blood, function of gallbladder promoting cures mainly distension and fullness of the chest and abdomen, the intestinal Huang calentura coma of having loose bowels, and is demented, spits blood stranguria with blood, sand Stranguria, jaundice, calentura coma, jaundice due to damp-heat etc.
Fructus Crataegi: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.The address eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipidemia;
Radix Glycyrrhizae: property is flat, sweet in the mouth.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen and extremity contraction, carbuncle sore tumefacting virus, but the toxicity of cushion is strong;
Fructus Amomi: the nature and flavor function, Xin Wen, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, preventing or arresting vomiting is antiabortive, cures mainly the stomach abdominal distention and pain;
Sea Piao sheath: another name Os Sepiae, ink fountain fishbone, it has astringing to arrest bleeding, relieving leukorrhea by astringents, the effect of antacid sore, seminal emission, spermatorrhea, red blood leukorrhagia are had blood in stool in the acid regurgitation that is used for having a stomachache, haematemesis, metrorrhagia;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication, it is damp and hot to be used for the intestines and stomach, sore and toxic, quench one's thirst etc., have antimicrobial, anti-bacteria, virus, fungus and protozoacide, antidiarrheal, stomach invigorating improves gastric juice, pancreatic juice, the secretion of bile, promote gastrointestinal motility, strengthen acetylcholine, make uterine contraction, spasmolytic reduces autonomic movement, lax gastrointestinal smooth muscle, suppress the spastic contraction of small intestinal, uterine smooth muscle is excited, immunomodulating, antiinflammatory, antiulcer, blood pressure lowering, intraocular pressure lowering, body-temp. reducing, prevention of arterial sclerosis, improve cerebral circulation, blood sugar lowering, blood fat reducing, anti peroxidation of lipid, free radical scavenging, function of gallbladder promoting, increase the effects such as bile formation and the discharge of promotion bilirubin, the clinical digestive system disease that is used for the treatment of, as: esophagitis, gastroduodenal ulcer, atrophic gastritis, ileotyphus, ulcerative colitis, chronic cholecystitis etc.;
Endothelium Corneum Gigeriae Galli: removing food stagnancy stagnates, and strengthening the spleen and stomach is controlled the food stagnation distension, vomiting regurgitation, and dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, the sore throat tonsillitis, the ulcerative gingivitis aphtha, stopping leak is smart, and hematuria, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery.Control diseases due to endogenous heat of ZANG FU organs, reduce phlegm, regulate the flow of vital energy, dampness removing.
Cortex Magnoliae Officinalis: retention of dampness in middle-JIAO, distension and fullness in the abdomen, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough, seven emotions pent-up, the mental disorder mutual resistance, in the pharynx if any thing resistance, pharynx time, the globus hystericus disease that does not go out of telling.
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Main trusted subordinate's pathogen, regulating the spleen and stomach is supported spleen, helps 12 warps.Flat gastric qi, logical nine orifices is mended weak breath, few body fluid, and is not enough, frightened in the body, heaviness of limbs, and hundred medicines;
The Pseudobulbus Bletillae (Rhizoma Bletillae): tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, the soup fire is burnt, rhagadia manus et pedis.Astringing to arrest bleeding, detumescence and promoting granulation.
Rhizoma Corydalis: blood-activating and qi-promoting, menstruction regulating and pain relieving except wind, is controlled gas, warm waist knee joint, broken disease addiction is pounced on the damage blood stasis, the tire that falls, and sudden and violent lumbago, promoting the circulation of QI, pain relieving, diuresis.
Propolis: propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for ulcerative colitis and clinical symptoms, the performance treating both the principal and secondary aspects of a disease effect.
The invention has the beneficial effects as follows: reasonable recipe, every drug synergism has heat clearing and damp drying, eliminating fire and detoxication, dispersing cold for relieving pain, depressed liver-energy dispersing and QI regulating, removing stasis to stop bleeding, tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema, the functions such as strengthening the spleen and nourishing the stomach, to the treatment ulcerative colitis, good effect, instant effect can reach the effect for the treatment of both the principal and secondary aspects of a disease, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.
The specific embodiment
Below in conjunction with embodiment embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only is used for explanation the present invention, and should not be considered as limiting scope of the present invention.
Embodiment one
A kind of preparation method for the treatment of the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 10 parts of Flos Chrysanthemis, 15 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Curcumaes, 10 parts of Fructus Crataegis, 5 parts in Radix Glycyrrhizae, 15 parts of Fructus Amomis, mix 5 minutes to even;
(3) take by weighing by weight 20 parts in extra large Piao sheath, 5 parts of Rhizoma Coptidis, 2 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Cortex Magnoliae Officinalis, 30 parts of Fructus Jujubae, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Rhizoma Corydalis, 25 parts of propolis, mix 5 minutes to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even, can make as required powder, tablet or pill.
Embodiment two
A kind of preparation method for the treatment of the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 30 parts of Flos Chrysanthemis, 25 parts of Pericarpium Citri Reticulataes, 30 parts of Radix Curcumaes, 30 parts of Fructus Crataegis, 15 parts in Radix Glycyrrhizae, 25 parts of Fructus Amomis, mix 10 minutes to even;
(3) take by weighing by weight 40 parts in extra large Piao sheath, 15 parts of Rhizoma Coptidis, 8 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Cortex Magnoliae Officinalis, 50 parts of Fructus Jujubae, 20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of Rhizoma Corydalis, 35 parts of propolis, mix 10 minutes to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even, can make as required powder, tablet or pill.
Embodiment three
A kind of preparation method for the treatment of the Chinese medicine composition of ulcerative colitis, concrete steps are as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 20 parts of Flos Chrysanthemis, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Radix Curcumaes, 20 parts of Fructus Crataegis, 10 parts in Radix Glycyrrhizae, 20 parts of Fructus Amomis, mix 5-10 minute to even;
(3) take by weighing by weight 30 parts in extra large Piao sheath, 10 parts of Rhizoma Coptidis, 5 parts of Endothelium Corneum Gigeriae Galli, 20 parts of Cortex Magnoliae Officinalis, 40 parts of Fructus Jujubae, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 25 parts of Rhizoma Corydalis, 30 parts of propolis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even, can make as required powder, tablet or pill.
Embodiment four
Clinical observation:
100 routine patients are carried out clinical observation treatment, man 47 wherein, woman 53, the age is between 21-40 year, 35 years old mean age, course of disease 2-5, average 3.5 years.
The Chinese medicine composition consumption for the treatment of ulcerative colitis of the present invention is every day twice, each 5g, and warm water delivery service, period in a medicine is prohibited raw food and irritable food, period in a medicine wine for giving off smoking, and pungent, stiff stodgy food.According to conditions of patients, patients with mild was taken about 25 days, and severe patient serve on about 90 days.
Therapeutic effect:
| Therapeutic effect | Cure | Produce effects | Effectively | Invalid |
| The example number | 76 | 17 | 4 | 3 |
| Percentage ratio | 76％ | 17％ | 4％ | 3％ |
The present invention prepares simply, and good absorbing effect is evident in efficacy, has no side effect, and is safe, is conducive to the patient and in time alleviates condition of illness.
Above-mentioned detailed description of the Chinese medicine composition and preparation method thereof for the treatment of ulcerative colitis being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (4)
1. Chinese medicine composition for the treatment of ulcerative colitis is characterized in that by following component mixed preparing by weight
2. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, it is characterized in that by following component by weight mixed preparing form:
3. the preparation method of the Chinese medicine composition of a treatment ulcerative colitis according to claim 1 is characterized in that concrete steps are as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Flos Chrysanthemi 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Radix Curcumae 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 5-15 part, Fructus Amomi 15-25 part, mix 5-10 minute to even;
(3) take by weighing by weight extra large Piao sheath 20-40 part, Rhizoma Coptidis 5-15 part, Endothelium Corneum Gigeriae Galli 2-8 part, Cortex Magnoliae Officinalis 15-25 part, Fructus Jujubae 30-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Rhizoma Corydalis 20-30 part, propolis 25-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
4. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1 is characterized in that dosage form is powder, tablet or pill.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436031A (en) * | 2014-11-17 | 2015-03-25 | 李先佳 | Medicine for treating ulcerative colitis |
| CN104740120A (en) * | 2015-02-12 | 2015-07-01 | 青岛静康医院 | Traditional Chinese medicine composition for dispelling wind and removing obstruction in the meridians as well as preparation method of traditional Chinese medicine composition and therapeutic equipment using traditional Chinese medicine combination |
| CN105012827A (en) * | 2015-07-25 | 2015-11-04 | 王璐 | Traditional Chinese drug treating colitis |
| CN105031501A (en) * | 2015-09-06 | 2015-11-11 | 张梅娟 | Composition for treating ulcerative colitis and preparing method thereof |
| CN105412609A (en) * | 2015-12-30 | 2016-03-23 | 张晓莉 | Traditional Chinese medicine for treating hepatic stagnation and spleen deficiency type ulcerative colitis and preparation method |
| CN105566029A (en) * | 2014-10-14 | 2016-05-11 | 中国石油化工股份有限公司 | Method for reducing ethene device energy consumption |
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Patent Citations (1)
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| CN102631617A (en) * | 2012-04-02 | 2012-08-15 | 宋立 | Method for preparing traditional Chinese medicine (TCM) for treating greasy food overeating type colitis |
Non-Patent Citations (1)
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| 南京中医药大学: "《中药大辞典》", 31 March 2006, article "白芨等", pages: 940 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105566029A (en) * | 2014-10-14 | 2016-05-11 | 中国石油化工股份有限公司 | Method for reducing ethene device energy consumption |
| CN104436031A (en) * | 2014-11-17 | 2015-03-25 | 李先佳 | Medicine for treating ulcerative colitis |
| CN104740120A (en) * | 2015-02-12 | 2015-07-01 | 青岛静康医院 | Traditional Chinese medicine composition for dispelling wind and removing obstruction in the meridians as well as preparation method of traditional Chinese medicine composition and therapeutic equipment using traditional Chinese medicine combination |
| CN105012827A (en) * | 2015-07-25 | 2015-11-04 | 王璐 | Traditional Chinese drug treating colitis |
| CN105031501A (en) * | 2015-09-06 | 2015-11-11 | 张梅娟 | Composition for treating ulcerative colitis and preparing method thereof |
| CN105412609A (en) * | 2015-12-30 | 2016-03-23 | 张晓莉 | Traditional Chinese medicine for treating hepatic stagnation and spleen deficiency type ulcerative colitis and preparation method |
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