CN105031501A - Composition for treating ulcerative colitis and preparing method thereof - Google Patents
Composition for treating ulcerative colitis and preparing method thereof Download PDFInfo
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- CN105031501A CN105031501A CN201510556189.7A CN201510556189A CN105031501A CN 105031501 A CN105031501 A CN 105031501A CN 201510556189 A CN201510556189 A CN 201510556189A CN 105031501 A CN105031501 A CN 105031501A
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Abstract
The invention discloses a composition for treating ulcerative colitis. The composition comprises, by weight, 3-8 parts of astilboides tabularis, 4-9 parts of peach kernel powder, 3-12 parts of caulis spatholobi, 15-60 parts of gynura segetum, 10-25 parts of psychotria calocarpa kurz, 9-15 parts of paleaceous knotweed rhizome, 6-15 parts of sea-buckthorn, 3-9 parts of bitter gourd, 1-3 parts of cuttlebone, 0.4-1 part of mirabilite, 0.6-1.5 parts of fructus amomi, 3-9 parts of carrots, 5-15 parts of liquorice and 0.2-0.6 part of betel nuts. The composition conforms to the principle of traditional Chinese medicine symptom distinguishing treatment of traditional Chinese doctors, the treatment effect is comprehensive, the medicine effect is lasting, and the composition is an ulcerative colitis prescription treating both symptoms and root causes; the selected traditional Chinese medicine materials have the effects of removing polyps and resolving hard lumps. The composition is used for various polyps such as a nasal polyp, a polyp of a vocal cord, a gastrointestinal polyp, gastric ulcer and uterus colpo-polyp clinically, and all the effects are good. The composition is an ideal medicine for treating ulcerative colitis.
Description
Technical field
The invention discloses a kind of compositions, especially treat the composition and method of making the same of ulcerative colitis, the invention belongs to traditional Chinese medicine field.
Background technology
Ulcerative colitis is a kind of cause of disease coton and rectal chronic nonspecific inflammation disease still not fully aware of, and pathological changes is confined to colorectal mucosa and Submucosa.Pathological changes multidigit, in sigmoid colon and rectum, also may extend to descending colon, even whole colon.The course of disease is very long, normal recurrent exerbation.Primary disease sees any age, but 20 ~ 30 years old the most common.
The cause of disease: the cause of disease of ulcerative colitis is still failed to understand so far.Genetic factors may have certain status.Psychological factor has critical role in disease progression, and unborn morbid state spirit is if depression or social distance are in the postoperative obvious improvement of colectomy.Have and think that ulcerative colitis is a kind of autoimmune disease.Think that the morbidity of inflammatory bowel is the result that allogenic material causes host response, gene and Immunological Effect triple interaction at present.According to this opinion, ulcerative colitis and crohn are the different manifestations of a lysis.
Clinical manifestation: the initial performance of ulcerative colitis can have many forms.Bloody diarrhea is modal early symptom.Other symptoms have stomachache successively, have blood in stool, lose weight, tenesmus, vomiting etc.Main manifestations is arthritis, iridocyclitis, hepatic insufficiency and dermatosis once in a while.Heating is then a uncommon sign relatively, and in most patient, primary disease shows as chronic, low pernicious, in the process that acute, calamity are broken out in a few patients (accounting for 15%).These patients show as frequent courageous and upright feces, can reach 30 times/day, and high heat, stomachache.Sign is directly related with stadium and clinical manifestation, and patient often loses weight and pale complexion, and when disease activity phase abdomen examination, colon site often has tenderness.May have acute abdomen sign occur together heat and borborygmus minimizing, acute attack or fulminant type case particularly evident.Abdominal distention, heating and acute abdomen sign can be had during toxic megacolon.Due to frequent diarrhoea, anal skin can have scratch, strip off.Also can there is crissum inflammation as anal fissure or anal fistula, although the latter is more common in Crohn disease.Digital rectal examination sense pain.The inspection of skin, mucosa, tongue, joint and eye is very important.
Authorization Notice No. CN102335341B(application number 201110290350.2) Chinese patent disclose a kind of Chinese medicinal clysis decoction for the treatment of ulcerative colitis, it is characterized in that this Chinese medicinal clysis decoction is made up of the Chinese medicine of following weight portion: Rhizoma Coptidis 12 parts, Herba Patriniae 10 parts, the Radix Paeoniae Alba 11 parts, Pericarpium Citri Reticulatae 12 parts, raw Fructus Hippophae 10 parts, Cortex Phellodendri 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, the Radix Pulsatillae 13 parts, Fructus Schisandrae Chinensis 8 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Radix Saposhnikoviae 9 parts, Rhizoma Corydalis 13 parts.Authorization Notice No.
CN103751299B(application number 201410053745.4) Chinese patent disclose a kind of Chinese medicine for the treatment of qi stagnation and blood stasis type ulcerative colitis, it is characterized in that it is made up of following raw material medicaments: Radix Polygoni hispidi 30-50 part, Herba Lactucae Indicae 20-40 part, Astilbo idestabularis (Hemsl.) Engler 20-40 part, Conyza canadensis (L.) Cronq. 15-25 part, Fructus Sophorae 15-25 part, Poria 15-25 part, Folium Perillae Frutescentis 15-25 part, Herba Patriniae 15-25 part, Caulis Millettiae Reticulatae 8-15 part, Rhizoma Corydalis 8-15 part.
As can be seen here, Chinese medicine occupies the status of very Chinese medicine in treatment ulcerative colitis, but in existing patent, most of crude drug is too many, and preparation method is complicated, and cost is too high.
Summary of the invention
For the present situation of existing treatment ulcerative colitis deficiency, an object of the present invention is to provide a kind of compositions for the treatment of ulcerative colitis, there is feature that is easy to operate, evident in efficacy, that have no side effect, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned treatment ulcerative colitis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a compositions for ulcerative colitis, take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 3-8 part, peach kernel powder 4-9 part, Caulis Spatholobi 3-12 part, Herba Senecionis Chrysanthemoidis 15-60 part, little contribution 10-25 part, Rhizoma Polygoni Paleachi 9-15 part, Fructus Hippophae 6-15 part, Fructus Momordicae charantiae 3-9 part, Endoconcha Sepiae 1-3 part, Natrii Sulfas 0.4-1 part, Fructus Amomi 0.6-1.5 part, Radix Dauci Sativae 3-9 part, Radix Glycyrrhizae 5-15 part, Semen Arecae 0.2-0.6 part.
Treat a compositions for ulcerative colitis, more preferably proportioning, take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 5-7 part, peach kernel powder 5-8 part, Caulis Spatholobi 5-10 part, Herba Senecionis Chrysanthemoidis 20-35 part, little contribution 12-20 part, Rhizoma Polygoni Paleachi 10-14 part, Fructus Hippophae 8-14 part, Fructus Momordicae charantiae 5-8 part, Endoconcha Sepiae 1.5-2.5 part, Natrii Sulfas 0.6-0.8 part, Fructus Amomi 0.9-1.3 part, Radix Dauci Sativae 5-8 part, Radix Glycyrrhizae 8-12 part, Semen Arecae 0.3-0.5 part.
Treat a compositions for ulcerative colitis, optimum proportioning, take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 6 parts, peach kernel powder 6 parts, Caulis Spatholobi 8 parts, Herba Senecionis Chrysanthemoidis 25 parts, little contribution 15 parts, Rhizoma Polygoni Paleachi 12 parts, Fructus Hippophae 12 parts, 7 parts, Fructus Momordicae charantiae, Endoconcha Sepiae 2 parts, 0.7 part, Natrii Sulfas, Fructus Amomi 1 part, 6 parts, Radix Dauci Sativae, 10 parts, Radix Glycyrrhizae, Semen Arecae 0.4 part.
Treat a preparation method for ulcerative colitis compositions, preparation process is as follows:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 80-120 mesh sieve, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 120-140 DEG C, sterilizing 5-15 is stand-by for second;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2-4 hour in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 20-40 minute, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 10-20 hour, elimination medicinal residues, obtain compositions.
The preparation method of above-mentioned composition, 1. step by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grinds to form smalls, crosses 90-110 mesh sieve (preferred, by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, to grind to form smalls, cross 100 mesh sieves).
The preparation method of above-mentioned composition, 2. step extrudes juice, sterilizing 8-13 second stand-by (preferred, extrude juice, at being placed in 130 DEG C, sterilizing 10 seconds is stand-by) at being placed in 125-135 DEG C.
The preparation method of above-mentioned composition, 3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2.5-3.5 hour (preferred, Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 3 hours in Oleum sesami) by step in Oleum sesami.
The preparation method of above-mentioned composition, step 4. intense fire is fried open, and turns slow fire boiling 25-35 minute (preferred, intense fire is fried open, and turns slow fire boiling 30 minutes).
The preparation method of above-mentioned composition, 5. step is firmly rocked and is made it melt completely, leaves standstill 13-18 hour (preferred, firmly to rock and make it melt completely, leave standstill 15 hours).
Using method: at every turn get present composition 3g, add the hot water dilution of 20g, three times on the one, drinking half an hour after meal, 5 days is a course for the treatment of.
Treat a compositions for ulcerative colitis, the pharmacological effect of each crude drug is respectively:
Astilbo idestabularis (Hemsl.) Engler: be root and the herb of dicotyledon medicine saxifragaceae plant Astilbo idestabularis (Hemsl.) Engler.Effect: astringent therapy, solid intestinal, antidiarrheal.
Cure mainly: availablely control diarrhoea.Meridian distribution of property and flavor: puckery is flat.Large intestine channel.
Peach kernel powder: peach kernel powder is after Semen Persicae fries, roll the fine powder after sieving, nature and flavor bitter, sweet, flat.Gui Jing: GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Cure mainly: for amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Caulis Spatholobi: chicken sedan-chair rattan bitter but slightly sweet taste, warm in nature, returns liver, the heart, kidney channel; Caulis Spatholobi red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.Efficacy effect: root and stem are Yunnan Caulis Spatholobi, and Caulis Spatholobi is medicinal, promoting the circulation of blood of enriching blood, dredge the meridian passage.1. the effect of pair hemopoietic system, the effect of 2. pair blood coagulation, fibrinolytic, 3. suppresses heart and the effect of reducing blood pressure, 4. antitumaous effect, the 5. adjustment of pair lipid metabolism.
Herba Senecionis Chrysanthemoidis: be root or the herb of Compositae Radix Gynurae platymiscium chrysanthemum leaf Radix Notoginseng.Composition: root is containing alkaloid: aureine., senlciphylline, sineciphyllinine, seneciphyllinine etc.Aerial parts contains PEARLITOL 25C, succinic acid, 5-methyl uracil, adenine, ammonium chloride, Radix gynurae segeti bases, rutin.The property of medicine: sweet, micro-hardship, temperature.Function cures mainly: removing blood stasis, detumescence, hemostasis, pain relieving.Cure mainly treating swelling and pain by traumatic injury, traumatic hemorrhage, congestion is spitted blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, dysmenorrhea, stomachache of being retarded by silt puerperal, rheumatalgia, carbuncle sore cellulitis furuncle, worm venom.
Little contribution: be the Herb of Rubiaceae Psychotria rubra (Lour.) Poir. platymiscium U.S. fruit Psychotria rubra (Lour.) Poir..The property of medicine: bitter, cool.Function cures mainly: " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, except wind dampness removing.Cure mainly bacillary dysentery, enteritis, diarrhoea, nephritis, cystitis, rheumatic lumbocrural pain, cough.
Rhizoma Polygoni Paleachi: be the rhizome of Polygonaceae arsesmart Rhizoma Polygoni Paleachi.Composition: Rhizoma Polygoni Paleachi rhizome is containing Combination tannin.The property of medicine: bitter, acrid, cold.Function cures mainly: dissipating blood stasis stops blooding, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, removing toxic substances, dampness removing.Zhu Zhi WEIJIA is gathered, traumatic injury, traumatic hemorrhage, spits blood, spitting of blood, epistaxis, amenorrhea, metrorrhagia, chronic gastritis, taste-blindness rate, and food stagnation is stagnated, dysentery, enteritis, edema, sore, venom, burn and scald.
Fructus Hippophae: be the fruit of Elaeangnaceae hippophae plant Chinese sea buckthorn and yunnan seabuckthorn.Composition: sea buckthorn fruit is containing pyrite constituents: isorhamnetin, isorhamnetin-3-O--D-Glucose glycosides, rutin, astragalin and Quercetin and kaempferol are the low glucosides etc. of aglycon.The property of medicine: " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, sour in the mouth, puckery." function cures mainly: relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm, pulmonary abscess, dyspepsia, abdominal pain due to retention of food, stomachache, enteritis, amenorrhea, traumatic injury congestive edema.
Fructus Momordicae charantiae: the nutritive value of Fructus Momordicae charantiae is very enriched, the clearing summer heat had, diuresis removing heat from blood, separate that labor clears away heart-fire, QI invigorating tonifying YANG, nourishing blood and invigorating qi, kidney and spleen invigorating, nourishing liver for improving eyesight effect, treatment dysentery, skin ulcer are swollen, heatstroke heating, miliaria too much, conjunctivitis etc. is sick certain effect.Fructus Momordicae charantiae bitter in the mouth cold in nature, enter the heart, lung, stomach, have that clearing away summer-heat quenches one's thirst, blood pressure lowering, blood fat, skin maintenance, the function such as enhance metabolism.Fructus Momordicae charantiae, containing abundant vitamin B1, vitamin C and mineral, eats for a long time, can keep full of vitality, has very large benefit to treatment comedo.
Endoconcha Sepiae: salty in the mouth, puckery, warm in nature.Gui Jing: return spleen, kidney channel.Effect: astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Be distributed in the ground such as Zhejiang, Fujian, Shandong.There is astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, effect of removing dampness sore.Be usually used in hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.
Natrii Sulfas: be the purification product of Sulfates Natrii Sulfas race mineral Natrii Sulfas.Composition: the main contains sodium sulfate of Natrii Sulfas, still containing impurity such as Sal, calcium sulfate and magnesium sulfate.The property of medicine: salty, bitter, cold.Return stomach, large intestine channel.Function cures mainly: pathogenic fire purging relieving constipation, softening the hard mass, detumescence.Cure mainly damp and hot stagnant, constipation, abdominal distention painful abdominal mass pain, acute appendicitis, acute mastitis, erysipelas, cataract, laryngopharynx swelling and pain, aphtha.
Fructus Amomi: Fructus Amomi ornamental value is higher, early summer can admire the beauty of flowers, midsummer considerable fruit.Fruit hyoscine, with the performance optimal in Guangdong spring, cure mainly stagnation of QI in spleen and stomach, dyspepsia does not disappear, and stomachache painful abdominal mass is swollen, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery.Amomum xanthioides fruit hyoscine, cure mainly stagnation of QI in spleen and stomach, dyspepsia does not disappear, and stomachache painful abdominal mass is swollen, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery.Short Fructus Amomi fruit hyoscine, effect and Fructus Amomi are similar to.Cure mainly stagnation of QI in spleen and stomach, dyspepsia does not disappear, and stomachache painful abdominal mass is swollen, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery.Fructus Amomi is containing volatile oil and Saponin.Volatile oil has digestion promoting function, can promote gastric secretion, gets rid of digestive tract pneumatosis.1. circulation of qi promoting stomach invigorating.For abdominal distention, anorexia that stagnation of QI in spleen and stomach causes, many and Pericarpium Citri Reticulatae, the Radix Aucklandiae are used together.2. removing dampness preventing or arresting vomiting.For all cards of the vexed vomiting and nausea of gastral cavity that taste humidity hysteresis causes.3. antiabortive.For vomiting during pregnancy, frequent fetal movement, many with fill blood, kidney-reinforcing drug is with using.Fructus Amomi pungent temperature row is loose, removing dampness by means of aromatics, main enter taste, for removing dampness for regulating stomach is amusing key medicine, have antiabortive merit concurrently.All middle burnt retention of damp leading to blockage of QI, and the disease such as frequent fetal movement, be conventional product.Fructus Amomi way instructs: gastral cavity raw meat distending pain, anorexia, the vomiting person of having loose bowels caused by all stagnation of QI in spleen and stomach dampness, the many and same use of the Radix Aucklandiae, and with disease compatibility other drug; If the partially cold person of malignant histocytosis, can join Rhizoma Zingiberis Recens juice; Partial heat person, can join Radix Scutellariae, Caulis Bambusae In Taenia etc., with the power helping the heat that disappears antiabortive.In addition, the merit of this product temperature drop still with controlling renal mass pain due to disorder of QI, often can be used together with the warming the interior such as Fructus Foeniculi, Fructus Evodiae cold expelling medicine.
Radix Dauci Sativae: carotene can remove the free radical causing people's aging, except vitamin A, the signboard nutrients such as contained vitamin B group and vitamin C also have profit skin, antidotal effect.The aromatic odor of Radix Dauci Sativae is that volatile oil causes.Can digestion be promoted, and have bactericidal action.Radix Dauci Sativae can strengthen body immunity, has antitumaous effect, and can alleviate the chemotherapy side effect of cancer patient, has protective effect to multiple internal organs.Women Radix Dauci Sativae of taking food can reduce the sickness rate of ovarian cancer.Radix Dauci Sativae includes glass amber acid potassium, contributes to preventing sclerosis of blood vessels, reducing cholesterol, having certain effect to preventing and treating hypertension.
Radix Glycyrrhizae: for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc., for stomachache, stomachache and the anxious pain of gastrocnemius contraction etc., Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
Semen Arecae: Semen Arecae is former is one of important medicinal plants, in south, fruit is chewed preference as one by some ethnic groups in addition.It is one of Chinese four great Nan medicines (other three kinds is Fructus Alpiniae Oxyphyllae, Fructus Amomi, bar halberd), and the various nutrient elements containing needed by human body and benefit materials, have removing food stagnancy, reduce phlegm, treat the effect such as malaria, parasite killing, is the medicine fruit that ancient Chinese medicine doctor is cured the disease.Cutting to boil water drinking open can ascarifuge.Arecoline is effective anthelmintic ingredient, has and significantly causes paralysis effect, have inhibitory action in various degree to dermatophytess such as trichophytons to cestode.In addition, the effect of arecoline is similar to pilocarpine effect, can glandular secretion be caused to increase by excited M-cholinoceptor, contracted pupil, shrinks bronchus, decreased heart rate, vasodilation, blood pressure drops.Prove in Semen Arecae containing the material to human carcinogen simultaneously.
The present composition meets the principle that disease treatment debated by Chinese medicine, therapeutic effect is comprehensive, affected area administration is rapider, lasting medicine, belong to the ulcerative colitis prescription for the treatment of both the principal and secondary aspects of a disease, the Chinese medicinal material selected all dispels polyp, hard masses softening and resolving, this Chinese medicine through clinical for various polyp as nasal polyp, polyp of vocal cord, gastric ulcer, uterus colpopolypus, all go through test not well, once nasopharyngeal carcinoma, uterus carcinoma, rectal cancer etc. are controlled in examination again, also have polyp to fade away, and unique curative effect that long-term observation does not recur.Therefore this Chinese medicine has the function of softening the hard mass, eliminating stagnation, change polyp, and life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of ulcerative colitis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1: one treats ulcerative colitis compositions, takes off and states raw material of Chinese medicine medicine: Astilbo idestabularis (Hemsl.) Engler 3 grams, peach kernel powder 4 grams, Caulis Spatholobi 3 grams, Herba Senecionis Chrysanthemoidis 15 grams, little contribution 10 grams, Rhizoma Polygoni Paleachi 9 grams, Fructus Hippophae 6 grams, 3 grams, Fructus Momordicae charantiae, Endoconcha Sepiae 1 gram, 0.4 gram, Natrii Sulfas, Fructus Amomi 0.6 gram, 3 grams, Radix Dauci Sativae, 5 grams, Radix Glycyrrhizae, Semen Arecae 0.2 gram.
The preparation method of above-mentioned composition, step is:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 80 mesh sieves, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 120 DEG C, sterilizing 5 seconds is stand-by;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2 hours in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 20 minutes, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 10 hours, elimination medicinal residues, obtain compositions.
embodiment 2:one treats ulcerative colitis compositions, takes off and states raw material of Chinese medicine medicine: Astilbo idestabularis (Hemsl.) Engler 5 grams, peach kernel powder 5 grams, Caulis Spatholobi 5 grams, Herba Senecionis Chrysanthemoidis 20 grams, little contribution 12 grams, Rhizoma Polygoni Paleachi 10 grams, Fructus Hippophae 8 grams, 5 grams, Fructus Momordicae charantiae, Endoconcha Sepiae 3 grams, 1 gram, Natrii Sulfas, Fructus Amomi 0.9 gram, 5 grams, Radix Dauci Sativae, 8 grams, Radix Glycyrrhizae, Semen Arecae 0.6 gram.
The preparation method of above-mentioned composition, step is:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 120 mesh sieves, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 140 DEG C, sterilizing 15 seconds is stand-by;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 4 hours in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 40 minutes, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 20 hours, elimination medicinal residues, obtain compositions.
embodiment 3:one treats ulcerative colitis compositions, takes off and states raw material of Chinese medicine medicine: Astilbo idestabularis (Hemsl.) Engler 7 grams, peach kernel powder 8 grams, Caulis Spatholobi 10 grams, Herba Senecionis Chrysanthemoidis 35 grams, little contribution 20 grams, Rhizoma Polygoni Paleachi 14 grams, Fructus Hippophae 14 grams, 8 grams, Fructus Momordicae charantiae, Endoconcha Sepiae 1.5 grams, 0.6 gram, Natrii Sulfas, Fructus Amomi 1.3 grams, 8 grams, Radix Dauci Sativae, 12 grams, Radix Glycyrrhizae, Semen Arecae 0.3 gram.
The preparation method of above-mentioned composition, step is:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 90 mesh sieves, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 125 DEG C, sterilizing 8 seconds is stand-by;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2.5 hours in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 25 minutes, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 13 hours, elimination medicinal residues, obtain compositions.
embodiment 4: one treats ulcerative colitis compositions, takes off and states raw material of Chinese medicine medicine: Astilbo idestabularis (Hemsl.) Engler 8 grams, peach kernel powder 9 grams, Caulis Spatholobi 12 grams, Herba Senecionis Chrysanthemoidis 60 grams, little contribution 25 grams, Rhizoma Polygoni Paleachi 15 grams, Fructus Hippophae 15 grams, 9 grams, Fructus Momordicae charantiae, Endoconcha Sepiae 2.5 grams, 0.8 gram, Natrii Sulfas, Fructus Amomi 1.5 grams, 9 grams, Radix Dauci Sativae, 15 grams, Radix Glycyrrhizae, Semen Arecae 0.5 gram.
The preparation method of above-mentioned composition, step is:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 110 mesh sieves, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 135 DEG C, sterilizing 13 seconds is stand-by;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 3.5 hours in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 35 minutes, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 18 hours, elimination medicinal residues, obtain compositions.
embodiment 5:one treats ulcerative colitis compositions, takes off and states raw material of Chinese medicine medicine: Astilbo idestabularis (Hemsl.) Engler 6 grams, peach kernel powder 6 grams, Caulis Spatholobi 8 grams, Herba Senecionis Chrysanthemoidis 25 grams, little contribution 15 grams, Rhizoma Polygoni Paleachi 12 grams, Fructus Hippophae 12 grams, 7 grams, Fructus Momordicae charantiae, Endoconcha Sepiae 2 grams, 0.7 gram, Natrii Sulfas, Fructus Amomi 1 gram, 6 grams, Radix Dauci Sativae, 10 grams, Radix Glycyrrhizae, Semen Arecae 0.4 gram.
The preparation method of above-mentioned composition, step is:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 100 mesh sieves, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 130 DEG C, sterilizing 10 seconds is stand-by;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 3 hours in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 30 minutes, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 15 hours, elimination medicinal residues, obtain compositions.
experimental example one:the clinical practice of the compositions of embodiment 5 gained treatment ulcerative colitis: screen 200 routine patients in 4 hospitals, before test 1 week, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine.
Curative effect situation criterion: cure: after taking and using this product, malaise symptoms disappears; Effective: after taking and using this product, malaise symptoms makes moderate progress; Invalid: after taking and using this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1:
| Group | Drug categories | Case load | Efficiently individual quantity | Healing number | Invalid number | Recurrence number | Cure rate | Total effective rate |
| Matched group | Use the medicine of other treatment ulcerative colitis | 100 people | 30 | 30 | 40 | 5 | 30% | 60% |
| Experimental group | The present composition | 100 people | 16 people | 80 people | 4 people | 0 | 80% | 96% |
Prove through clinical trial, the present composition is to ulcerative colitis Be very effective, total effective rate is 96%, cure rate is 80%, general patient just can have significant curative effect in 1-3 days in use, and present composition multiselect use can heat-clearing and toxic substances removing, only has blood in stool, antibacterial virus killing, improves the medicine of abdominal distention, being a kind of medicine for the treatment of ulcerative colitis safely and fast, is treat the ideal medicine of ulcerative colitis at present.
Claims (9)
1. treat a compositions for ulcerative colitis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 3-8 part, peach kernel powder 4-9 part, Caulis Spatholobi 3-12 part, Herba Senecionis Chrysanthemoidis 15-60 part, little contribution 10-25 part, Rhizoma Polygoni Paleachi 9-15 part, Fructus Hippophae 6-15 part, Fructus Momordicae charantiae 3-9 part, Endoconcha Sepiae 1-3 part, Natrii Sulfas 0.4-1 part, Fructus Amomi 0.6-1.5 part, Radix Dauci Sativae 3-9 part, Radix Glycyrrhizae 5-15 part, Semen Arecae 0.2-0.6 part.
2. the compositions for the treatment of ulcerative colitis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 5-7 part, peach kernel powder 5-8 part, Caulis Spatholobi 5-10 part, Herba Senecionis Chrysanthemoidis 20-35 part, little contribution 12-20 part, Rhizoma Polygoni Paleachi 10-14 part, Fructus Hippophae 8-14 part, Fructus Momordicae charantiae 5-8 part, Endoconcha Sepiae 1.5-2.5 part, Natrii Sulfas 0.6-0.8 part, Fructus Amomi 0.9-1.3 part, Radix Dauci Sativae 5-8 part, Radix Glycyrrhizae 8-12 part, Semen Arecae 0.3-0.5 part.
3. the compositions for the treatment of ulcerative colitis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Astilbo idestabularis (Hemsl.) Engler 6 parts, peach kernel powder 6 parts, Caulis Spatholobi 8 parts, Herba Senecionis Chrysanthemoidis 25 parts, little contribution 15 parts, Rhizoma Polygoni Paleachi 12 parts, Fructus Hippophae 12 parts, 7 parts, Fructus Momordicae charantiae, Endoconcha Sepiae 2 parts, 0.7 part, Natrii Sulfas, Fructus Amomi 1 part, 6 parts, Radix Dauci Sativae, 10 parts, Radix Glycyrrhizae, Semen Arecae 0.4 part.
4. the preparation method of the treatment ulcerative colitis compositions according to any one of claim 1-3, is characterized in that: step is as follows:
1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 80-120 mesh sieve, the smalls after sieving is placed in the close bundle of matter, seals for subsequent use;
2. Fructus Momordicae charantiae and Radix Dauci Sativae are cleaned, diced, smash to pieces and be broken into mud, be placed in gauze, with hands pressing, extrude juice, at being placed in 120-140 DEG C, sterilizing 5-15 is stand-by for second;
3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2-4 hour in Oleum sesami, boil and play cigarette to surrounding, Chinese herbal medicine boils to micro-withered, oil dripping Cheng Zhuwei degree in Oleum sesami, and endure and wait medicine oil temperature to be down to room temperature elimination medicinal residues afterwards, medicine oil is stand-by;
4. Caulis Spatholobi, Rhizoma Polygoni Paleachi and Fructus Hippophae are put into non iron container, add water, intense fire is fried open, and turns slow fire boiling 20-40 minute, filters, obtains filtrate;
5. by step 1.-4. gains together put in transparent container, add peach kernel powder after mixing, firmly rock and make it melt completely, leave standstill 10-20 hour, elimination medicinal residues, obtain compositions.
5. the preparation method of compositions according to claim 4, it is characterized in that: step is 1. by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 90-110 mesh sieve (preferred, by crisp to Endoconcha Sepiae, Natrii Sulfas, Fructus Amomi and Semen Arecae forging, grind to form smalls, cross 100 mesh sieves).
6. the preparation method of compositions according to claim 4, is characterized in that: 2. step extrudes juice, sterilizing 8-13 second stand-by (preferred, extrude juice, at being placed in 130 DEG C, sterilizing 10 seconds is stand-by) at being placed in 125-135 DEG C.
7. the preparation method of compositions according to claim 4, it is characterized in that: 3. Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 2.5-3.5 hour (preferred, Astilbo idestabularis (Hemsl.) Engler, Herba Senecionis Chrysanthemoidis, little contribution and Radix Glycyrrhizae are soaked 3 hours in Oleum sesami) by step in Oleum sesami.
8. the preparation method of compositions according to claim 4, is characterized in that: step 4. intense fire is fried open, and turns slow fire boiling 25-35 minute (preferred, intense fire is fried open, and turns slow fire boiling 30 minutes).
9. the preparation method of compositions according to claim 4, is characterized in that: 5. step is firmly rocked and made it melt completely, leaves standstill 13-18 hour (preferred, firmly to rock and make it melt completely, leave standstill 15 hours).
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| CN105687481A (en) * | 2016-03-04 | 2016-06-22 | 薛文婷 | Composition for treating ulcerative colitis and preparation method thereof |
| CN115400160A (en) * | 2022-04-27 | 2022-11-29 | 贵州民族大学 | Application of saponins endosperm extract in preparation of medicine for treating ulcerative colitis |
| CN115400160B (en) * | 2022-04-27 | 2023-06-20 | 贵州民族大学 | Application of saponins endosperm extract in preparation of medicine for treating ulcerative colitis |
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